carbamates has been researched along with givinostat in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 22 (61.11) | 24.3611 |
| 2020's | 14 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Amaru Calzada, A; Donadoni, L; Finazzi, G; Gatta, R; Golay, J; Introna, M; Lombardi, L; Mantovani, R; Neri, A; Pellicioli, A; Rambaldi, A; Todoerti, K; Tuana, G | 1 |
| Amaru Calzada, A; Finazzi, G; Golay, J; Introna, M; Leoni, F; Mascagni, P; Pedrini, O; Rambaldi, A | 1 |
| Bettica, P; Consalvi, S; Del Bene, F; Fiorentini, F; Germani, M; Leoni, F; Mascagni, P; Monzani, V; Mozzetta, C; Puri, PL; Rocchetti, M; Saccone, V | 1 |
| Barbui, T; Barosi, G; Cilloni, D; Demuth, T; Finazzi, G; Finazzi, MC; Fioritoni, G; Martinelli, V; Musolino, C; Nobile, F; Olimpieri, OM; Pogliani, EM; Rambaldi, A; Ruggeri, M; Sivera, P; Specchia, G; Tollo, SD; Vannucchi, AM | 1 |
| Anichini, A; Carbone, A; Carlo-Stella, C; Cleris, L; Locatelli, SL; Malorni, W; Pierdominici, M; Saba, E; Stirparo, GG; Tartari, S | 1 |
| Cappellini, MD; Fossati, G; Modena, D; Porretti, L; Ronzoni, L; Sonzogni, L; Trombetta, E | 1 |
| Christensen, DP; Dahllöf, MS; Harving, M; Lundh, M; Mandrup-Poulsen, T; Wagner, BK | 1 |
| Miyamoto, T; Yoshimoto, G | 1 |
| Consalvi, S; Mozzetta, C; Saccone, V | 1 |
| Cleophas, MC; Crişan, TO; Dinarello, CA; Fossati, G; Jansen, TL; Joosten, LA; Lemmers, H; Netea, MG; Toenhake-Dijkstra, H | 1 |
| Meng, WY; Shi, M; Wang, N; Wang, T; Wang, YG; Wei, J; Xu, L | 1 |
| Agnusdei, V; Amadori, A; Basso, G; Borga, C; De Paoli, A; Fossati, G; Indraccolo, S; Michielotto, B; Minuzzo, S; Paganin, M; Pinazza, M; te Kronnie, G | 1 |
| Arent, T; Deenen, R; Hoffmann, MJ; Köhrer, K; Niegisch, G; Pinkerneil, M; Schulz, WA | 1 |
| Ganai, SA | 1 |
| Bertini, E; Bettica, P; Brajkovic, S; Catteruccia, M; Comi, GP; D'Amico, A; D'Oria, V; De Nicolao, G; Gatti, B; Magri, F; Mercuri, E; Messina, S; Moggio, M; Pane, M; Petrini, S; Puri, PL; Rocchetti, M; Sivo, S; Vita, G; Vita, GL | 1 |
| Gao, L; He, C; Li, M; Sun, Y; Wu, Q; Zeng, T | 1 |
| Bardini, M; Biondi, A; Bugarin, C; Cazzaniga, G; Davis, KL; Fazio, G; Fossati, G; Gaipa, G; Izraeli, S; Meyer, LH; Nolan, GP; Palmi, C; Sarno, J; Savino, AM; Te Kronnie, G; Trentin, L; Vieri, M | 1 |
| Jones, D; Li, Y; Lyu, L; Ru, P; Tang, Y; Walker, A; Yao, C; Zhang, G; Zhao, KY; Zhao, W | 1 |
| Baci, D; Bearzi, C; Chirivì, M; De Falco, E; Frati, G; Maccari, S; Madaro, L; Maiullari, F; Maiullari, S; Marano, G; Milan, M; Pace, V; Puri, PL; Rizzi, R; Stati, T | 1 |
| Budillon, A; Codenotti, S; Fanzani, A; Ferella, L; Festuccia, C; Galbiati, E; Gravina, GL; Leoni, F; Maggio, R; Mancini, A; Marampon, F; Mascagni, P; Megiorni, F; Pietrantoni, I; Porro, G; Pozzi, P; Tombolini, V | 1 |
| Friedrich, M; Gerbeth, L; Gerling, M; Glauben, R; Keye, J; Rosenthal, R; Schmidt, F; Siegmund, B; Steiger, K; Weichert, W; Weidinger, C; Wu, H | 1 |
| Bettica, P; De Nicolao, G; Lavezzi, SM; Petrini, S; Rocchetti, M | 1 |
| Bettica, P; Cambier, N; Carli, G; De Muro, M; Di Tollo, S; Gesullo, F; Guarini, A; Iurlo, A; Luciani, S; Manzoni, S; Marolleau, JP; Martino, B; McMullin, MF; Mesa, RA; Noble, R; Pancrazzi, A; Pezzutto, A; Rambaldi, A; Tibes, R; Vannucchi, AM; von Bubnoff, N | 1 |
| Bose, P; Chifotides, HT; Verstovsek, S | 1 |
| Datta, S; Patel, D; Patel, M; Singh, U | 1 |
| Ashraf, M; Khan, M; Xuan, W | 1 |
| Fan, SJ; Huang, HM; Huang, J; Li, GM; Liao, LP; Liu, YJ; Luo, C; Pen, JJ; Shi, CC; Yu, L; Zhang, YY; Zhou, XR | 1 |
| Bettica, P; De Muro, M; Di Tollo, S; Guarini, A; Iurlo, A; Luciani, S; Manzoni, S; Martinelli, V; Martino, B; McMullin, MF; Nogai, A; Rambaldi, A; Ricco, A; Rosti, V; Ruggeri, M; Vannucchi, AM; von Bubnoff, N | 1 |
| Barbieri, C; Catarinella, G; Cervia, D; Clementi, E; De Palma, C; Giovarelli, M; Latella, L; Moscheni, C; Napoli, A; Perrotta, C; Roux-Biejat, P; Sartori, P; Vantaggiato, C; Zecchini, S | 1 |
| Crippa, L; Fossati, G; Leoni, F; Licandro, SA; Perego, R; Pomarico, R; Steinkühler, C | 1 |
| Fan, JG; Fan, SJ; Fu, R; Huang, HM; Huang, J; Li, GM; Li, X; Liao, LP; Liu, YJ; Luo, C; Shi, CC; Yu, L; Zhang, YY; Zhou, XR | 1 |
| Dikmen, M; Kaya-Tilki, E | 1 |
| Dibekoğlu, C; Erbaş, O | 1 |
| Pawelec, P; Sypecka, J; Zalewska, T; Ziemka-Nalecz, M | 1 |
| Cavioli, G; Cedola, A; Coletti, D; Gigli, G; McKinsey, TA; Moresi, V; Renzini, A; Saccone, V; Sandonà, M | 1 |
| Bettica, P; Cazzaniga, S; Del Bene, F; Fiorentini, F; Germani, M; Pellizzoni, C; Rocchetti, M | 1 |
5 review(s) available for carbamates and givinostat
| Article | Year |
|---|---|
[Treatment strategy for myeloproliferative neoplasms].
Topics: Adrenal Cortex Hormones; Aspirin; Calreticulin; Carbamates; Clinical Trials as Topic; Drug Therapy, Combination; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Immunosuppressive Agents; Janus Kinase 2; Molecular Targeted Therapy; Mutation; Nitriles; Platelet Aggregation Inhibitors; Polycythemia Vera; Primary Myelofibrosis; Prognosis; Pyrazoles; Pyrimidines; Quinazolines; Receptors, Thrombopoietin; Thalidomide; Thrombocythemia, Essential | 2014 |
Histone deacetylase inhibitors: a potential epigenetic treatment for Duchenne muscular dystrophy.
Topics: Acetylation; Animals; Carbamates; Cell Differentiation; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histones; Humans; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Mutation; Regeneration; Satellite Cells, Skeletal Muscle | 2014 |
Histone deacetylase inhibitor givinostat: the small-molecule with promising activity against therapeutically challenging haematological malignancies.
Topics: Antineoplastic Agents; Carbamates; Hematologic Neoplasms; Histone Deacetylase Inhibitors; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders | 2016 |
Givinostat: an emerging treatment for polycythemia vera.
Topics: Animals; Carbamates; Disease Progression; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Janus Kinase 2; Mutation; Polycythemia Vera | 2020 |
Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies.
Topics: Carbamates; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Muscle, Skeletal; Muscular Dystrophy, Duchenne | 2023 |
6 trial(s) available for carbamates and givinostat
| Article | Year |
|---|---|
A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Male; Middle Aged; Nucleic Acid Synthesis Inhibitors; Polycythemia Vera; Treatment Failure; Treatment Outcome | 2013 |
Histological effects of givinostat in boys with Duchenne muscular dystrophy.
Topics: Adrenal Cortex Hormones; Carbamates; Child; Dose-Response Relationship, Drug; Histone Deacetylase Inhibitors; Humans; Male; Motor Activity; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Platelet Count; Treatment Outcome | 2016 |
Assessing drug effect from distributional data: A population approach with application to Duchenne Muscular Dystrophy treatment.
Topics: Adrenal Cortex Hormones; Algorithms; Biopsy; Carbamates; Child; Data Interpretation, Statistical; Databases, Factual; Dose-Response Relationship, Drug; Humans; Male; Maximum Tolerated Dose; Models, Statistical; Muscle Fibers, Skeletal; Muscular Dystrophy, Duchenne; Normal Distribution; Reproducibility of Results | 2019 |
Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Female; Humans; Janus Kinase 2; Male; Maximum Tolerated Dose; Middle Aged; Mutation; Polycythemia Vera; Quality of Life | 2020 |
Long-term safety and efficacy of givinostat in polycythemia vera: 4-year mean follow up of three phase 1/2 studies and a compassionate use program.
Topics: Adult; Aged; Carbamates; Female; Follow-Up Studies; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Polycythemia Vera; Treatment Outcome | 2021 |
Population pharmacokinetic-pharmacodynamic analysis of givinostat.
Topics: Carbamates; Child; Humans; Male; Models, Biological; Muscular Dystrophy, Duchenne; Weight Gain | 2023 |
25 other study(ies) available for carbamates and givinostat
| Article | Year |
|---|---|
The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells.
Topics: Carbamates; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Janus Kinase 2; Mutation; Myeloproliferative Disorders; NF-E2 Transcription Factor, p45 Subunit; Phosphorylation; Proto-Oncogene Proteins c-myb; Pyrimidines; Signal Transduction; Sulfonamides | 2012 |
Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients.
Topics: Amino Acid Substitution; Antineoplastic Agents; Apoptosis; Blotting, Western; Carbamates; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Humans; Hydroxyurea; Janus Kinase 2; Leukocytes, Mononuclear; Mutation; Myeloproliferative Disorders; Polycythemia Vera | 2013 |
Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat.
Topics: Animals; Carbamates; Cells, Cultured; Exercise Test; Fibrosis; Histone Deacetylase Inhibitors; Humans; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts; Running | 2013 |
BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbamates; Cell Line, Tumor; Histone Deacetylase Inhibitors; Hodgkin Disease; Humans; Imidazoles; Indoles; Membrane Proteins; Mice; Mice, SCID; Necrosis; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Reactive Oxygen Species; Sorafenib; Up-Regulation; Xenograft Model Antitumor Assays | 2014 |
Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.
Topics: Adult; Anemia, Sickle Cell; Antigens, CD34; Butyric Acid; Carbamates; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythroid Precursor Cells; Erythropoiesis; gamma-Globins; Gene Expression Regulation; Hemoglobins; Histone Deacetylase Inhibitors; Humans; Hydroxyurea | 2014 |
HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent.
Topics: Animals; Apoptosis; Carbamates; Cell Line; Chemokine CXCL10; Chemokine CXCL9; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Rats; STAT1 Transcription Factor | 2015 |
Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.
Topics: Adult; Antioxidants; Arthritis, Gouty; Butyrates; Carbamates; Crystallization; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Indoles; Interleukin-1beta; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged; Palmitic Acid; Panobinostat; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uric Acid | 2016 |
Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Topics: Acetylation; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbamates; Carbon Tetrachloride; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line; Cell Movement; Cell Proliferation; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Histone Deacetylase Inhibitors; Liver Cirrhosis, Experimental; Male; Mice, Inbred BALB C; NF-kappa B; Protein Processing, Post-Translational; Signal Transduction; Superoxide Dismutase; Time Factors | 2015 |
An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.
Topics: Animals; Apoptosis; Carbamates; Cell Differentiation; Cell Line, Tumor; DNA Damage; Histone Deacetylase Inhibitors; Humans; Mice; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Xenograft Model Antitumor Assays | 2016 |
Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carbamates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Depsipeptides; Gene Knockdown Techniques; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Urinary Bladder Neoplasms | 2016 |
Givinostat exhibits in vitro synergy with posaconazole against Aspergillus spp.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Carbamates; Drug Synergism; Microbial Sensitivity Tests; Triazoles | 2017 |
The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.
Topics: Adolescent; Animals; Carbamates; Cell Line, Tumor; Child, Preschool; Female; Histone Deacetylase Inhibitors; Humans; Male; Mice; Nitriles; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrimidines; Receptors, Cytokine; STAT5 Transcription Factor; Xenograft Model Antitumor Assays | 2017 |
Potent induction of apoptosis by givinostat in BCR-ABL1-positive and BCR-ABL1-negative precursor B-cell acute lymphoblastic leukemia cell lines.
Topics: Apoptosis; Carbamates; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation.
Topics: Animals; Apoptosis; Carbamates; Endothelium; Epithelium; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Ventricular Remodeling | 2018 |
Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma.
Topics: Animals; Apoptosis; Carbamates; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Glioblastoma; Histone Deacetylases; Humans; In Vitro Techniques; Male; Mice; Mice, Nude; Neoplastic Stem Cells; Phenotype; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation.
Topics: Animals; Autocrine Communication; Carbamates; Cells, Cultured; Colitis; Disease Models, Animal; Electric Impedance; Epithelial Cells; Histone Deacetylase Inhibitors; Humans; Inflammatory Bowel Diseases; Intestines; Mice; Mice, Inbred C57BL; Regeneration; Signal Transduction; Tight Junctions; Transforming Growth Factor beta1; Vorinostat; Wound Healing | 2019 |
An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1.
Topics: Carbamates; DNA; DNA-Binding Proteins; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Immunoblotting; Protein Binding; Small Molecule Libraries | 2020 |
Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis and restore dystrophin in injured Duchenne dystrophic muscle.
Topics: Animals; Carbamates; Dystrophin; Humans; Induced Pluripotent Stem Cells; Mice; Mice, Inbred mdx; Mice, SCID; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts | 2021 |
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation.
Topics: Animals; Carbamates; Carbon Tetrachloride; Cell Line; Female; Gene Expression Profiling; Gene Expression Regulation; GPI-Linked Proteins; Hepatic Stellate Cells; Histone Deacetylase Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Mesothelin; Mice; Mice, Inbred C57BL; Rats; Uroplakin III | 2021 |
Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy.
Topics: Acetylation; Animals; Carbamates; Disease Models, Animal; Energy Metabolism; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Mice, Inbred mdx; Mitochondria, Muscle; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Promoter Regions, Genetic | 2021 |
The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene.
Topics: Animals; Carbamates; Disease Models, Animal; Haplotypes; Histone Deacetylase Inhibitors; Humans; Latent TGF-beta Binding Proteins; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne | 2021 |
Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis.
Topics: Animals; Carbamates; Histone Deacetylase Inhibitors; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Chlamydophila Infections; Chlamydophila pneumoniae; Epigenesis, Genetic; Humans; Hydroxamic Acids; Inflammation; Neuroprotective Agents; Peptide Fragments; Phthalimides; THP-1 Cells; Tryptophan | 2021 |
Histone deacetylase inhibitor givinostat has ameliorative effect in the colitis model.
Topics: Acetic Acid; Animals; Carbamates; Colitis; Colitis, Ulcerative; Colon; Histone Deacetylase Inhibitors; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2022 |
Analysis of Givinostat/ITF2357 Treatment in a Rat Model of Neonatal Hypoxic-Ischemic Brain Damage.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Carbamates; Cytokines; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Inflammation; Ischemia; Rats | 2022 |