carbamates has been researched along with gamma-aminobutyric acid in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.06) | 18.2507 |
| 2000's | 31 (32.98) | 29.6817 |
| 2010's | 56 (59.57) | 24.3611 |
| 2020's | 6 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Kapetanovic, IM; Kupferberg, HJ; Yonekawa, WD | 1 |
| Dost, R; Rundfeldt, C | 1 |
| Cagiano, R; Coluccia, A; Cuomo, V; Gaetani, S; Kendrick, KM; Pietra, C; Tattoli, M; Trabace, L | 1 |
| Cassano, T; Cuomo, V; Kendrick, KM; Pietra, C; Steardo, L; Trabace, L; Villetti, G | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Rundfeldt, C; Sills, GJ; Thompson, GG | 1 |
| Netzer, R; Rundfeldt, C | 1 |
| Capell, A; Edbauer, D; Haass, C; Kaether, C; Lammich, S; Okochi, M; Steiner, H; Takeda, M; Walter, J; Zimmer, AK | 1 |
| Field, MJ; Gonzalez, MI; Singh, L; Tallarida, RJ | 1 |
| Rekling, JC | 1 |
| Onal, S; Telefoncu, A | 1 |
| van Rijn, CM; Willems-van Bree, E | 2 |
| Alves Da Costa, C; Andrau, D; Ayral, E; Checler, F; Dumanchin-Njock, C; Farzan, M; Fulcrand, P; Hernandez, JF; Marambaud, P; Martinez, J; Pasini, A; Petit, A; Phiel, CJ; Wilk, S | 1 |
| Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M | 1 |
| Dost, R; Rostock, A; Rundfeldt, C | 1 |
| Daniele, A; Di Lazzaro, V; Dileone, M; Gainotti, G; Ghirlanda, S; Marra, C; Oliviero, A; Pilato, F; Saturno, E; Tonali, PA | 1 |
| Barrett, RW; Branch, R; Chernov-Rogan, T; Cundy, KC; Dias, T; Estrada, T; Gallop, MA; Hold, K; Koller, K; Liu, X; Mann, A; Panuwat, M; Raillard, SP; Upadhyay, S; Wu, QQ; Xiang, JN; Yan, H; Zerangue, N; Zhou, CX | 1 |
| Annamalai, T; Barrett, RW; Bu, L; Cundy, KC; De Vera, J; Estrela, J; Gallop, MA; Luo, W; Shirsat, P; Torneros, A; Yao, F; Zou, J | 1 |
| Komano, H; Kurono, Y; Maeda, Y; Nishimura, M; Sai, X; Shiraishi, H; Wang, HQ; Yanagisawa, K | 1 |
| Green, AC; Harrison, PK; Sheridan, RD; Tattersall, JE | 1 |
| Fukuyama, T; Fuwa, H; Iwatsubo, T; Kan, T; Morohashi, Y; Natsugari, H; Okamura, Y; Sato, C; Tominari, Y; Tomita, T; Watanabe, N | 1 |
| Miura, Y | 1 |
| Kaname, M; Sashida, H; Yoshifuji, S | 1 |
| Cherubini, E; Safiulina, VF; Taglialatela, M; Yaari, Y; Zacchi, P | 1 |
| Mayo, KE; Trombly, DJ; Woodruff, TK | 1 |
| Canafax, DM; Cundy, KC; Luo, W; Moors, TL; Sastry, S; Zou, J | 1 |
| Gigli, GL; Merlino, G; Robiony, F; Serafini, A; Valente, M; Young, JJ | 1 |
| Barrett, RW; Becker, PM; Canafax, DM; Ellenbogen, AL; Kushida, CA | 1 |
| Barrett, RW; Becker, P; Canafax, D; Kushida, CA; Perkins, AT; Roth, T; Thein, SG; Walters, AS | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, SC | 1 |
| Kovacs, FE; Szabo, B; Urbanski, MJ | 1 |
| Chen, D; Cundy, KC; Lal, R; Luo, W; Sukbuntherng, J; Tovera, J; Vu, A | 1 |
| Cundy, KC; Huff, FJ; Lal, R; Luo, W; Sukbuntherng, J; Zou, J | 1 |
| Gigli, GL; Lorenzut, S; Merlino, G; Serafini, A; Sommaro, M; Valente, M | 1 |
| Bernardi, G; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Mataluni, G; Musella, A; Rossi, S | 1 |
| Alger, BE; Kim, J | 1 |
| Kaba, H; Takahashi, Y | 1 |
| Barrett, RW; Bogan, RK; Bornemann, MA; Kushida, CA; Trân, PV | 1 |
| Blumenthal, R; Cundy, KC; Ho, J; Lal, R; Luo, W; Sukbuntherng, J; Vicente, V | 1 |
| Imamura, S; Kushida, C | 1 |
| Cundy, KC; Ho, J; Lal, R; Sukbuntherng, J | 1 |
| Bhanegaonkar, A; Bharmal, M; Calloway, M; Canafax, DM | 1 |
| Bogan, RK; DeRossett, SE; Hill-Zabala, CE; Hudson, JD; Schmidt, MH; Winkelman, JW | 1 |
| Backonja, MM; Canafax, DM; Cundy, KC | 1 |
| Barrett, RW; Lee, DO; Perkins, AT; Poceta, JS; Walters, AS; Ziman, RB | 1 |
| Hattori, N; Hirata, K; Inoue, Y; Kuroda, K; Uchimura, N | 1 |
| Burke, RA; Faulkner, MA | 1 |
| Blumenthal, R; Chen, D; Cundy, KC; Ho, J; Lal, R; Luo, W; Sukbuntherng, J | 1 |
| Farver, DK; Hayes, WJ; Lemon, MD | 1 |
| Atluri, H; Bonzo, D; Chen, D; Cundy, K; Ho, J; Lal, R; Luo, W; Tovera, J; Zomorodi, K | 1 |
| Dekeyser, MA; Hiragaki, S; Kobayashi, T; Matsuda, K; Ochiai, N; Takeda, M; Toshima, K | 1 |
| de Biase, S; Gigli, GL; Lorenzut, S; Merlino, G; Valente, M | 1 |
| Barrett, RW; Kavanagh, ST; VanMeter, SA; Warren, S | 1 |
| Aurora, RN; Bista, SR; Casey, KR; Kristo, DA; Lamm, CI; Rosenberg, RS; Rowley, JA; Tracy, SL; Zak, RS | 1 |
| Igarashi, K; Kakimoto, S; Kaku, S; Ozawa, T; Seki, N; Tokuno, T | 1 |
| Barker, E; Chester, JA; Cooper, BR; Davisson, VJ; Han, B; Kirchhoff, AM; Wright, R | 1 |
| Hattori, N; Hirata, K; Inoue, Y; Kuroda, K; Takeuchi, M; Uchimura, N | 1 |
| Ascher, J; Goode-Sellers, S; Saiers, J; Silberstein, S; Twomey, C | 1 |
| Scott, LJ | 1 |
| Bell, CF; Graff, O; Kavanagh, ST; Makumi, CW; McClung, CL; Meno-Tetang, G; Rauck, R; Schwartz, S | 1 |
| Cundy, KC; Lal, R; Lassauzet, ML; Luo, W; Sukbuntherng, J; Tovera, J | 1 |
| Bell, CF; Chen, C; Freeman, R; Graff, O; Harden, RN; Harding, K; Hunter, S; Kavanagh, S; Laurijssens, B; McClung, C; Rainka, M; Schwartzbach, C; Warren, S; Zhang, L | 1 |
| Chen, C | 1 |
| Chronicle, EP; Linde, M; McCrory, DC; Mulleners, WM | 1 |
| Argoff, CE; Harden, RN; Kaye, AD; Kintanar, T | 1 |
| Bell, C; Berges, A; Chen, C; Freeman, R; Graff, O; Harden, RN; Harding, K; Hunter, S; Kavanagh, S; McClung, C; Rainka, M; Schwartzbach, C; Warren, S; Zhang, L | 1 |
| Arumugham, T; Chen, C; Davy, M; Stier, B; Twomey, C; Upward, J | 1 |
| Fujishiro, H | 1 |
| Earley, CJ | 1 |
| Toro, BE | 1 |
| Morel, T; Sun, Y; van Valkenhoef, G | 1 |
| Arumugham, T; Chen, C; Davy, M; Stier, B; Upward, J | 1 |
| Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J | 1 |
| Bedse, G; Bellomo, A; Cassano, T; Cifani, C; Duranti, A; Gaetani, S; Lavecchia, MA; Micioni Di Bonaventura, MV; Pace, L; Romano, A; Tempesta, B | 1 |
| Bogan, RK; Buchfuhrer, MJ; Jaros, MJ; Kim, R; Lee, DO; Shang, G | 1 |
| Calkins, AM; Gidal, B; Gudin, J; Jaros, MJ; Kim, R; Shang, G | 1 |
| Avidan, AY; Jaros, MJ; Kim, R; Lee, D; Park, M; Shang, G | 1 |
| Buchfuhrer, M; Ellenbogen, A; Hermanowicz, N; Irving, G; Jaros, MJ; Kim, R; Shang, G | 1 |
| Deeks, ED; Kim, ES | 1 |
| Ahmed, M; Avidan, AY; Buchfuhrer, MJ; Garcia-Borreguero, D; Hays, R; Jaros, MJ; Kim, R; Lee, DO; Ondo, WG; Shang, G | 1 |
| Ahmed, M; Hays, R; Jaros, MJ; Kim, R; Shang, G; Steven Poceta, J | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Wang, J; Zhu, Y | 1 |
| Faulkner, MA | 1 |
| Jaros, MJ; Winkelman, JW | 1 |
| Ait-Daoud Tiouririne, N; Brooks, C; Brown, ES; Brunette, MF; Burns, H; Caras, S; Cruz, R; Devine, EG; Dunn, KE; Falk, DE; Fertig, JB; Galloway, G; Green, AI; Gunderson, EW; Kampman, K; Leggio, L; Litten, RZ; Mason, BJ; Mendelson, J; Newport, DJ; Ransom, J; Ray, L; Rosenthal, RN; Ryan, ML; Salloum, IM; Scott, C; Shoptaw, S; Strain, EC | 1 |
| Cano-Pumarega, I; Cruz Velarde, JA; Garcia Malo, C; Garcia-Borreguero, D; Granizo, JJ; Wanner, V | 1 |
| Allen, R; Fry, L; Gooneratne, N; Hanlon, A; Kovach, C; Loera, A; Lozano, A; Morrison, J; Rangel, A; Richards, K; Wang, YY | 1 |
| Bogenschutz, M; Laska, EM; Lin, Z; Marmar, CR; Siegel, CE | 1 |
| Hirata, K; Hoshino, Y; Inoue, Y; Yamaguchi, Y | 1 |
| Ellenbogen, A; Gidal, B; Lal, R | 1 |
| Ayad, SS; Khoshknabi, DS; Kim, DD; Makarova, N; Niazi, AK; Raza, S; Stang, T | 1 |
| Jithavech, P; Muangnoi, C; Rojsitthisak, P; Suwattananuruk, P; Thitikornpong, W; Towiwat, P; Vajragupta, O | 1 |
20 review(s) available for carbamates and gamma-aminobutyric acid
| Article | Year |
|---|---|
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
Gabapentin enacarbil in restless legs syndrome.
Topics: Carbamates; Clinical Trials as Topic; Delayed-Action Preparations; gamma-Aminobutyric Acid; Humans; Prodrugs; Restless Legs Syndrome; Severity of Illness Index | 2010 |
Gabapentin enacarbil (XP13512/GSK1838262) as an alternative treatment to dopaminergic agents for restless legs syndrome.
Topics: Carbamates; Dopamine Agents; gamma-Aminobutyric Acid; Humans; Restless Legs Syndrome | 2010 |
Gabapentin enacarbil for the treatment of restless legs syndrome (RLS).
Topics: Administration, Oral; Calcium Channels; Carbamates; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Molecular Structure; Protein Binding; Restless Legs Syndrome; Treatment Outcome | 2011 |
Gabapentin enacarbil for treatment of restless legs syndrome in adults.
Topics: Adult; Animals; Calcium Channel Blockers; Carbamates; gamma-Aminobutyric Acid; Humans; Prodrugs; Restless Legs Syndrome | 2012 |
ADMET considerations for restless leg syndrome drug treatments.
Topics: Amines; Anticonvulsants; Benzothiazoles; Carbamates; Cyclohexanecarboxylic Acids; Dopamine Agents; Dopamine Agonists; Ergolines; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Neuralgia; Pramipexole; Pregabalin; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome | 2012 |
Dose response of Gabapentin Enacarbil versus placebo in subjects with moderate-to-severe primary restless legs syndrome: an integrated analysis of three 12-week studies.
Topics: Carbamates; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Endpoint Determination; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Multicenter Studies as Topic; Patient Satisfaction; Placebos; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Severity of Illness Index; Treatment Outcome | 2012 |
The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.
Topics: Academies and Institutes; Benzothiazoles; Cabergoline; Carbamates; Dopamine Agents; Ergolines; Evidence-Based Medicine; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Nocturnal Myoclonus Syndrome; Pergolide; Peripheral Nervous System Diseases; Pramipexole; Restless Legs Syndrome; Sleep Medicine Specialty; United States; Venous Insufficiency | 2012 |
[Pharmacological and clinical profile of gabapentin enacarbil: a novel drug for the treatment of restless legs syndrome].
Topics: Animals; Biological Availability; Carbamates; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Prodrugs; Rats; Restless Legs Syndrome; Treatment Outcome | 2012 |
Gabapentin enacarbil: in patients with restless legs syndrome.
Topics: Animals; Carbamates; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Humans; Polysomnography; Randomized Controlled Trials as Topic; Restless Legs Syndrome | 2012 |
Meta-analyses of dose-exposure relationships for gabapentin following oral administration of gabapentin and gabapentin enacarbil.
Topics: Administration, Oral; Amines; Biological Availability; Carbamates; Computer Simulation; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Gabapentin; gamma-Aminobutyric Acid; Humans; Models, Biological; Prodrugs | 2013 |
Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults.
Topics: Adult; Amines; Anticonvulsants; Carbamates; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Pregabalin; Randomized Controlled Trials as Topic | 2013 |
Evidence-based guidance for the management of postherpetic neuralgia in primary care.
Topics: Amines; Analgesics; Capsaicin; Carbamates; Cyclohexanecarboxylic Acids; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia, Postherpetic; Practice Guidelines as Topic; Pregabalin; Primary Health Care | 2013 |
Latest guidelines and advances for treatment of restless legs syndrome.
Topics: Amines; Analgesics, Opioid; Carbamates; Cyclohexanecarboxylic Acids; Dopamine Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Iron Compounds; Pregabalin; Restless Legs Syndrome | 2014 |
New treatment options for the management of restless leg syndrome.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Carbamates; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Guideline Adherence; Humans; Middle Aged; Nursing Diagnosis; Pregnancy; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Young Adult | 2014 |
Gabapentin Enacarbil: A Review in Restless Legs Syndrome.
Topics: Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Multicenter Studies as Topic; Pain Management; Prodrugs; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Sleep | 2016 |
Effect of Gabapentin Enacarbil on Individual Items of the International Restless Legs Study Group Rating Scale and Post-sleep Questionnaire in Adults with Moderate-to-Severe Primary Restless Legs Syndrome: Pooled Analysis of 3 Randomized Trials.
Topics: Carbamates; Dizziness; Double-Blind Method; Fatigue; gamma-Aminobutyric Acid; Humans; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Severity of Illness Index; Sleep; Sleep Wake Disorders; Surveys and Questionnaires | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Different doses of gabapentin formulations for postherpetic neuralgia: A systematical review and meta-analysis of randomized controlled trials.
Topics: Amines; Analgesics; Carbamates; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia, Postherpetic; Randomized Controlled Trials as Topic | 2017 |
Use of α2δ Ligands for Restless Legs Syndrome/Willis Ekbom Disease.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamates; Gabapentin; gamma-Aminobutyric Acid; Humans; Ligands; Pregabalin; Restless Legs Syndrome | 2018 |
32 trial(s) available for carbamates and gamma-aminobutyric acid
| Article | Year |
|---|---|
Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin.
Topics: Adult; Aged; Amines; Area Under Curve; Biological Availability; Capsules; Carbamates; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Headache; Humans; Male; Middle Aged; Molecular Structure; Molecular Weight; Prodrugs; Sleep Wake Disorders; Young Adult | 2008 |
Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS.
Topics: Adult; Amines; Anti-Anxiety Agents; Carbamates; Central Nervous System; Cyclohexanecarboxylic Acids; Disorders of Excessive Somnolence; Dizziness; Double-Blind Method; Drug Administration Schedule; Endpoint Determination; Female; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Placebos; Restless Legs Syndrome; Sleep Initiation and Maintenance Disorders; Treatment Outcome | 2009 |
A randomized, double-blind, placebo-controlled, crossover study of XP13512/GSK1838262 in the treatment of patients with primary restless legs syndrome.
Topics: Adult; Aged; Carbamates; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Polysomnography; Restless Legs Syndrome; Wakefulness | 2009 |
Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: a randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers.
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Biological Availability; Carbamates; Chromatography, Liquid; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Prodrugs; Tandem Mass Spectrometry; Young Adult | 2009 |
The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil.
Topics: Adult; Amines; Anticonvulsants; Area Under Curve; Biological Availability; Carbamates; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dietary Fats; Female; Food-Drug Interactions; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Prodrugs; Young Adult | 2010 |
Long-term maintenance treatment of restless legs syndrome with gabapentin enacarbil: a randomized controlled study.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Double-Blind Method; Drug Tolerance; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Restless Legs Syndrome | 2010 |
A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers.
Topics: Adolescent; Adult; Area Under Curve; Carbamates; Carbon Radioisotopes; gamma-Aminobutyric Acid; Humans; Male; Middle Aged | 2011 |
Validation of the post sleep questionnaire for assessing subjects with restless legs syndrome: results from two double-blind, multicenter, placebo-controlled clinical trials.
Topics: Adult; Aged; Carbamates; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Middle Aged; Outcome Assessment, Health Care; Psychometrics; Reproducibility of Results; Restless Legs Syndrome; Sleep; Statistics as Topic; Surveys and Questionnaires; Treatment Outcome | 2011 |
Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome.
Topics: Adolescent; Adult; Aged; Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Polysomnography; Restless Legs Syndrome; Treatment Outcome; Young Adult | 2011 |
Efficacy of gabapentin enacarbil vs placebo in patients with postherpetic neuralgia and a pharmacokinetic comparison with oral gabapentin.
Topics: Adult; Aged; Amines; Analgesics; Carbamates; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Placebos; Treatment Outcome; Young Adult | 2011 |
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome.
Topics: Analysis of Variance; Carbamates; Disorders of Excessive Somnolence; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; GABA Agents; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Restless Legs Syndrome; Severity of Illness Index; Treatment Outcome | 2011 |
Long-term efficacy and safety of gabapentin enacarbil in Japanese restless legs syndrome patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Carbamates; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Quality of Life; Restless Legs Syndrome; Severity of Illness Index; Sleep Wake Disorders; Time Factors | 2012 |
Clinical pharmacokinetics of gabapentin after administration of gabapentin enacarbil extended-release tablets in patients with varying degrees of renal function using data from an open-label, single-dose pharmacokinetic study.
Topics: Administration, Oral; Adult; Aged; Analgesics; Anticonvulsants; Biomarkers; Biotransformation; Carbamates; Creatinine; Delayed-Action Preparations; Female; Florida; gamma-Aminobutyric Acid; Humans; Hydrolysis; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Minnesota; Models, Biological; Prodrugs; Renal Dialysis; Severity of Illness Index; Tablets | 2012 |
Evaluation of gabapentin enacarbil on cardiac repolarization: a randomized, double-blind, placebo- and active-controlled, crossover thorough QT/QTc study in healthy adults.
Topics: Adolescent; Adult; Carbamates; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; gamma-Aminobutyric Acid; Heart; Humans; Male; Middle Aged | 2012 |
Gabapentin enacarbil in Japanese patients with restless legs syndrome: a 12-week, randomized, double-blind, placebo-controlled, parallel-group study.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Japan; Male; Middle Aged; Restless Legs Syndrome | 2013 |
Randomized, double-blind, placebo-controlled, phase II trial of gabapentin enacarbil for migraine prophylaxis.
Topics: Adult; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Migraine Disorders; Pain Measurement; Placebo Effect; Treatment Outcome | 2013 |
A randomized, controlled trial of gabapentin enacarbil in subjects with neuropathic pain associated with diabetic peripheral neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Treatment Outcome | 2013 |
Population pharmacokinetics and pharmacodynamics of gabapentin after administration of gabapentin enacarbil.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Carbamates; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Models, Biological; Prodrugs; Restless Legs Syndrome; Sleep Initiation and Maintenance Disorders; Young Adult | 2013 |
A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain Measurement; Time Factors; Treatment Outcome; Young Adult | 2013 |
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain Measurement; Prodrugs; Treatment Outcome | 2013 |
Cardiac repolarization with Gabapentin enacarbil in a randomized, double-blind, placebo- and active-controlled, crossover thorough QT/QTc study in healthy adults.
Topics: Adolescent; Adult; Aza Compounds; Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; gamma-Aminobutyric Acid; Heart; Heart Rate; Humans; Male; Middle Aged; Moxifloxacin; Quinolines; Young Adult | 2013 |
Gabapentin enacarbil and morphine administered in combination versus alone: a double-blind, randomized, pharmacokinetic, and tolerability comparison.
Topics: Adult; Amines; Analgesics, Opioid; Carbamates; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dizziness; Double-Blind Method; Dyssomnias; Electrocardiography; Gabapentin; gamma-Aminobutyric Acid; Healthy Volunteers; Humans; Male; Middle Aged; Morphine; Nausea; Prodrugs; Young Adult | 2015 |
Treatment response to sleep, pain, and mood disturbance and their correlation with sleep disturbance in adult patients with moderate-to-severe primary restless legs syndrome: Pooled analyses from 3 trials of gabapentin enacarbil.
Topics: Adult; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Mood Disorders; Pain; Quality of Life; Restless Legs Syndrome; Sleep Wake Disorders; Treatment Outcome | 2015 |
Impact of Data Imputation Methodology on Pain Assessment over 24 Hours in a Randomized, Placebo-Controlled Study of Gabapentin Enacarbil in Patients with Neuropathic Pain Associated with Postherpetic Neuralgia.
Topics: Adult; Analgesics; Carbamates; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Models, Statistical; Neuralgia, Postherpetic; Pain Measurement; Research Design; Treatment Outcome | 2016 |
The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome.
Topics: Affect; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Membrane Transport Modulators; Middle Aged; Psychiatric Status Rating Scales; Psychotropic Drugs; Quality of Life; Restless Legs Syndrome; Severity of Illness Index; Treatment Outcome | 2016 |
Predictors of clinical response in a double-blind placebo controlled crossover trial of gabapentin enacarbil for restless legs syndrome.
Topics: Carbamates; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Polysomnography; Restless Legs Syndrome; Sleep; Sleep Wake Disorders; Surveys and Questionnaires; Treatment Outcome | 2018 |
Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial Assessing Efficacy and Safety.
Topics: Adult; Alcoholism; Behavior Therapy; Carbamates; Combined Modality Therapy; Delayed-Action Preparations; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Prodrugs; Therapy, Computer-Assisted; Treatment Outcome; Young Adult | 2019 |
Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.
Topics: Aged; Carbamates; Cross-Over Studies; Dopamine Agents; Double-Blind Method; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Restless Legs Syndrome; Time Factors; Treatment Outcome | 2019 |
Nighttime Agitation and Restless Legs Syndrome in Persons With Alzheimer's Disease: Study Protocol for a Double-Blind, Placebo-Controlled, Randomized Trial (NightRest).
Topics: Aged; Alzheimer Disease; Anxiety; Carbamates; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Restless Legs Syndrome; Sleep; Treatment Outcome | 2020 |
Gabapentin Enacarbil Extended-Release Versus Placebo: A Likely Responder Reanalysis of a Randomized Clinical Trial.
Topics: Adult; Alcoholism; Carbamates; Female; gamma-Aminobutyric Acid; Humans; Machine Learning; Male; Middle Aged; Outcome Assessment, Health Care; Precision Medicine | 2020 |
Difference in background factors between responders to gabapentin enacarbil treatment and responders to placebo: pooled analyses of two randomized, double-blind, placebo-controlled studies in Japanese patients with restless legs syndrome.
Topics: Carbamates; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Japan; Restless Legs Syndrome; Treatment Outcome | 2021 |
Effects of Gabapentin Enacarbil on Postoperative Pain After Hip and Knee Arthroplasty: A Placebo-controlled Randomized Trial.
Topics: Adult; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Carbamates; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Morphine; Pain Measurement; Pain, Postoperative | 2022 |
42 other study(ies) available for carbamates and gamma-aminobutyric acid
| Article | Year |
|---|---|
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Phenylenediamines; Rats; Rats, Inbred Strains; Tetrodotoxin | 1995 |
The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.
Topics: Animals; Anticonvulsants; Calcium; Carbamates; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Male; Phenylenediamines; Potassium Channels; Rats; Rats, Wistar | 2000 |
In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus.
Topics: Acetylcholine; Animals; Carbamates; Cholinesterase Inhibitors; Dopamine; gamma-Aminobutyric Acid; Hippocampus; Male; Norepinephrine; Phenylcarbamates; Rats; Rats, Wistar; Rivastigmine; Serotonin | 2000 |
Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease.
Topics: Acetylcholine; Administration, Oral; Alzheimer Disease; Animals; Avoidance Learning; Brain Chemistry; Carbamates; Cholinesterase Inhibitors; Cyclic N-Oxides; Dopamine; gamma-Aminobutyric Acid; Male; Phenylcarbamates; Rats; Rats, Wistar; Serotonin | 2000 |
A neurochemical study of the novel antiepileptic drug retigabine in mouse brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Chemistry; Carbamates; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glutamine; Male; Mice; Mice, Inbred ICR; Phenylenediamines | 2000 |
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamates; Cells, Cultured; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Ion Channel Gating; Kainic Acid; Neurons; Patch-Clamp Techniques; Phenylenediamines; Rats; Sodium Channels; Synaptic Transmission | 2000 |
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Cell Membrane; Dipeptides; Endopeptidases; Enzyme Inhibitors; Fibroblasts; gamma-Aminobutyric Acid; Humans; Hyaluronan Receptors; Membrane Proteins; Mice; Mice, Knockout; Molecular Sequence Data; Peptides; Presenilin-1; Presenilin-2; Protein Structure, Tertiary; Sequence Alignment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triglycerides | 2002 |
Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain.
Topics: Acetates; Amines; Animals; Benzofurans; Carbamates; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Rats; Rats, Sprague-Dawley | 2002 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Comparison of chitin and Amberlite IRA-938 for alpha-galactosidase immobilization.
Topics: alpha-Galactosidase; Anion Exchange Resins; Carbamates; Chitin; Citrullus; Cross-Linking Reagents; Enzymes, Immobilized; gamma-Aminobutyric Acid; Imidazoles; Methods | 2003 |
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex.
Topics: Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Kinetics; Models, Biological; Phenylenediamines; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 2003 |
JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anticoagulants; Aspartic Acid Endopeptidases; Blotting, Western; Cadherins; Carbamates; Cell Line; Cysteine Endopeptidases; Dipeptides; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryo, Nonmammalian; Endopeptidases; gamma-Aminobutyric Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; In Situ Hybridization; In Vitro Techniques; Kidney; Membrane Proteins; Multienzyme Complexes; Mutation; Peptide Fragments; Precipitin Tests; Proteasome Endopeptidase Complex; Receptors, Notch; Time Factors; Transfection; Triglycerides; Zebrafish | 2003 |
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes | 2004 |
A four-ligand hypercube model to quantify allosteric interactions within the GABAA receptor complex.
Topics: Allosteric Site; Animals; Binding Sites; Carbamates; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ligands; Models, Chemical; Models, Molecular; Models, Neurological; Phenylenediamines; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Peripheral Nervous System Diseases; Phenylenediamines; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Spinal Nerves; Touch; Tramadol | 2004 |
Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease.
Topics: Afferent Pathways; Aged; Alzheimer Disease; Carbamates; Cerebral Cortex; Cholinergic Fibers; Cholinesterase Inhibitors; Evoked Potentials, Motor; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Motor Cortex; Muscle, Skeletal; N-Methylaspartate; Nerve Net; Neural Inhibition; Phenylcarbamates; Reaction Time; Rivastigmine; Sensory Thresholds; Signal Processing, Computer-Assisted; Transcranial Magnetic Stimulation | 2004 |
XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters.
Topics: Amines; Animals; Biological Transport; Caco-2 Cells; Carbamates; CHO Cells; Cricetinae; Cyclohexanecarboxylic Acids; Cytochrome P-450 Enzyme System; Dogs; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Intestinal Mucosa; Large Neutral Amino Acid-Transporter 1; Membranes, Artificial; Monocarboxylic Acid Transporters; Prodrugs; Protein Binding; Rats; Symporters | 2004 |
XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys.
Topics: Administration, Oral; Amines; Animals; Biological Availability; Carbamates; Colon; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Haplorhini; Injections, Intravenous; Intestinal Absorption; Prodrugs; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution | 2004 |
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Blotting, Western; Carbamates; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; gamma-Aminobutyric Acid; Gene Expression Regulation; Membrane Glycoproteins; Membrane Proteins; Mice; Peptide Fragments; Presenilin-1; Presenilin-2; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Radioimmunoassay; Statistics, Nonparametric; Transgenes; Triglycerides | 2004 |
Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus.
Topics: Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Chlormethiazole; Clozapine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Levetiracetam; Male; Phenylcarbamates; Phenylenediamines; Piracetam; Propylene Glycols; Soman; Topiramate | 2005 |
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Carbamates; Chromatography; Dipeptides; Endopeptidases; gamma-Aminobutyric Acid; HeLa Cells; Humans; Inhibitory Concentration 50; Membrane Proteins; Models, Chemical; Peptides; Presenilin-1; Protein Structure, Tertiary; Receptors, Notch; Triglycerides | 2006 |
An efficient transformation of cyclic ene-carbamates into omega-(N-formylamino)carboxylic acids by ruthenium tetroxide oxidation.
Topics: Carbamates; Carboxylic Acids; Carnitine; Catalysis; Crystallization; Cyclization; gamma-Aminobutyric Acid; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Ruthenium Compounds; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared | 2008 |
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Topics: Action Potentials; Animals; Animals, Newborn; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Indoles; KCNQ2 Potassium Channel; Kinetics; Nerve Net; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Synaptic Transmission | 2008 |
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.
Topics: Amyloid Precursor Protein Secretases; Animals; Animals, Newborn; Carbamates; Cell Differentiation; Cells, Cultured; Dipeptides; Down-Regulation; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Germ Cells; Mice; Ovarian Follicle; Ovary; Receptors, Notch; Signal Transduction; Triglycerides | 2009 |
Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome.
Topics: Animals; Carbamates; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Humans; Prodrugs; Restless Legs Syndrome; Treatment Outcome | 2009 |
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Drug Antagonism; Electroacupuncture; Endocannabinoids; gamma-Aminobutyric Acid; Hemodynamics; Male; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex; Stomach; Sympathetic Nervous System | 2009 |
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine | 2009 |
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum.
Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Corpus Striatum; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Neural Inhibition; Organ Culture Techniques; Polyunsaturated Alkamides; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Sensory System Agents; Synaptic Transmission; TRPV Cation Channels | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb.
Topics: Alkaloids; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels, R-Type; Carbachol; Carbamates; Cholinergic Agonists; Dendrites; Diclofenac; Excitatory Amino Acid Antagonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; KCNQ Potassium Channels; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Naphthalenes; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phenylenediamines; Piperidines; Pirenzepine; Potassium Channel Blockers; Receptor, Muscarinic M1; Receptors, Glutamate; Synapses | 2010 |
Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine.
Topics: Adolescent; Adult; Biological Transport; Carbamates; Cimetidine; Constipation; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Dyspepsia; Fatigue; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Naproxen; Prodrugs; Young Adult | 2010 |
Gabapentin encarbil (Horizant) for restless leg syndrome.
Topics: Carbamates; Delayed-Action Preparations; gamma-Aminobutyric Acid; Humans; Restless Legs Syndrome | 2011 |
A novel action of highly specific acaricide; bifenazate as a synergist for a GABA-gated chloride channel of Tetranychus urticae [Acari: Tetranychidae].
Topics: Acaricides; Animals; Binding Sites; Carbamates; Chloride Channels; Cloning, Molecular; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hydrazines; Imides; Ion Channel Gating; Membrane Potentials; Protein Conformation; Receptors, GABA; Structure-Activity Relationship; Tetranychidae; Xenopus laevis | 2012 |
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.
Topics: Amidohydrolases; Amino Acids; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Mice; Polyunsaturated Alkamides; Tandem Mass Spectrometry | 2013 |
Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies.
Topics: Aged; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Japan; Leg; Lewy Body Disease; Magnetic Resonance Imaging; Pain; Restless Legs Syndrome; Treatment Outcome | 2014 |
A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome.
Topics: Adult; Aged; Bayes Theorem; Benzothiazoles; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Humans; Indoles; Male; Middle Aged; Pramipexole; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome | 2014 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; HIV Envelope Protein gp120; HIV Infections; Hyperalgesia; Male; Nociception; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Sciatic Neuropathy | 2015 |
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Chromatography, High Pressure Liquid; Disease Models, Animal; Endocannabinoids; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Microdialysis; Norepinephrine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological; Swimming | 2015 |
The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials.
Topics: Adult; Aged; Carbamates; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Quality of Life; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Treatment Outcome; Young Adult | 2016 |
Efficacy of gabapentin enacarbil in adult patients with severe primary restless legs syndrome.
Topics: Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Quality of Life; Randomized Controlled Trials as Topic; Restless Legs Syndrome | 2016 |
Interindividual Variability in the Bioavailability of Gabapentin Enacarbil Extended Release in Healthy Adults: An Analysis of Data From 6 Phase I Studies.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Carbamates; Cross-Over Studies; Gabapentin; gamma-Aminobutyric Acid; Humans | 2022 |
Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity.
Topics: Aminobutyrates; Carbamates; Curcumin; Esters; gamma-Aminobutyric Acid; Prodrugs | 2022 |