carbamates has been researched along with epothilone a in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 19 (82.61) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Service, RF | 1 |
| Chakravarty, S; Danishefsky, SJ; He, L; Horwitz, SB; Inoue, T; Kuduk, SD; Lin, S; Ojima, I | 1 |
| Arimoto, H; Danishefsky, SJ; Horwitz, SB; Kaufman, MD; Martello, LA; McDaid, HM; Meng, D; Pettus, TR; Regl, DL; Smith, AB; Yang, CP | 1 |
| Adler, AJ; Crabtree, DV; Geng, X; Ojima, I | 1 |
| Chen, JG; Horwitz, SB | 1 |
| Bröker, LE; Ferreira, CG; Giaccone, G; Huisman, C; Kruyt, FA; Rodriguez, JA | 1 |
| Myles, DC | 1 |
| Braguer, D; Briand, C; Honore, S; Jordan, MA; Kamath, K; Wilson, L | 1 |
| Bröker, LE; Giaccone, G; Huisman, C; Kruyt, FA; Rodriguez, JA; Span, SW | 1 |
| Dabydeen, DA; Florence, GJ; Hamel, E; Paterson, I | 1 |
| Colevas, D; Fojo, T; Goel, S; Macapinlac, M; Mani, S; Rothenberg, M; Verdier-Pinard, D | 1 |
| Horwitz, SB; Huang, H; Kalpana, G; Liu, W; Mani, S; Smith, AB; Sundarababu, S | 1 |
| Escuin, D; Giannakakou, P; Kline, ER | 1 |
| Bergstralh, DT; Ting, JP | 1 |
| Carlomagno, T; Kubicek, K; Lyothier, I; Meiler, J; Paterson, I; Sánchez-Pedregal, VM | 1 |
| Andreu, JM; Barasoain, I; Buey, RM; Calvo, E; Cerezo, G; Day, BW; Díaz, JF; Edler, MC; Hamel, E; López, JA; Matesanz, R; Pineda, O; Sorensen, EJ; Vanderwal, CD | 1 |
| Horwitz, SB; Wiesen, KM; Xia, S; Yang, CP | 1 |
| Balachandran, R; Curran, DP; Day, BW; Fukui, Y; Jung, WH; Madiraju, C; Montgomery, K; Raccor, BS; Shin, Y; Sikorski, RP; Vogt, A | 1 |
| Mooberry, SL | 1 |
| Altmann, KH; Gertsch, J; Meier, S; Müller, M | 1 |
| Mulzer, J; Prantz, K | 2 |
| Goldberg, GL; Horwitz, SB; Shahabi, S; Yang, CP | 1 |
4 review(s) available for carbamates and epothilone a
| Article | Year |
|---|---|
Novel biologically active natural and unnatural products.
Topics: Alkanes; Antifungal Agents; Carbamates; Epothilones; Erythromycin; Furans; Gram-Positive Bacteria; Lactones; Lipids; Macrolides; Models, Chemical; Pyrones; Structure-Activity Relationship; Taxoids | 2003 |
The clinical development of new mitotic inhibitors that stabilize the microtubule.
Topics: Alkanes; Animals; Carbamates; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drug Screening Assays, Antitumor; Epothilones; Humans; Lactones; Microtubule-Associated Proteins; Microtubules; Mitosis; Molecular Structure; Multicenter Studies as Topic; Pyrones | 2004 |
Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combination.
Topics: Alkanes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Cyclooxygenase 2; Diterpenes; Epothilones; Humans; Inhibitor of Apoptosis Proteins; Interleukin-1; Interleukin-8; Lactones; Macrolides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Maturation-Promoting Factor; Microtubule-Associated Proteins; Microtubules; Neoplasm Proteins; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrones; Signal Transduction; Survivin; Taxoids; Tumor Suppressor Protein p53 | 2006 |
Strategies for the development of novel Taxol-like agents.
Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Docetaxel; Drug Design; Drug Resistance, Neoplasm; Epothilones; Humans; Lactones; Microtubules; Paclitaxel; Pyrones; Taxoids | 2007 |
19 other study(ies) available for carbamates and epothilone a
| Article | Year |
|---|---|
Tumor-killer made; how does it work?
Topics: Alkanes; Antineoplastic Agents; Carbamates; Computer Simulation; Epothilones; Epoxy Compounds; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured | 1996 |
A common pharmacophore for cytotoxic natural products that stabilize microtubules.
Topics: Alkaloids; Alkanes; Antineoplastic Agents, Phytogenic; Carbamates; Computer Graphics; Diterpenes; Epothilones; Epoxy Compounds; Lactones; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Thiazoles | 1999 |
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.
Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carbamates; Cell Count; Cell Division; Cell Line; Cytoskeleton; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epothilones; Epoxy Compounds; Flow Cytometry; Humans; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured | 2000 |
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site.
Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Carbamates; Carotenoids; Diterpenes; Epothilones; Epoxy Compounds; Haplorhini; Humans; Lactones; Ligands; Lutein; Models, Molecular; Molecular Sequence Data; Paclitaxel; Pyrones; Retina; Thiazoles; Tubulin | 2001 |
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.
Topics: Alkanes; Aneuploidy; Antineoplastic Agents; Carbamates; Carcinoma, Non-Small-Cell Lung; Epothilones; Humans; Lactones; Lung Neoplasms; Macrolides; Microtubules; Mitosis; Paclitaxel; Pyrones; Spindle Apparatus; Tumor Cells, Cultured | 2002 |
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
Topics: Alkanes; Antineoplastic Agents; Apoptosis; Carbamates; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Caspases; Epothilones; Humans; Inhibitory Concentration 50; Jurkat Cells; Lactones; Lung Neoplasms; Macrolides; Mitochondria; Pyrones; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured | 2002 |
Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.
Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Division; Cell Line, Tumor; Epothilones; Humans; Lactones; Microtubules; Mitosis; Paclitaxel; Pyrones | 2003 |
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.
Topics: Alkanes; Antineoplastic Agents; Apoptosis; Base Sequence; Carbamates; Carcinoma, Non-Small-Cell Lung; Caspases; Cathepsin B; Cell Death; DNA Primers; Epothilones; Humans; Lactones; Lung Neoplasms; Lysosomes; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pyrones; Transfection; Tumor Cells, Cultured | 2004 |
A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel.
Topics: Alkanes; Carbamates; Dose-Response Relationship, Drug; Epothilones; Guanosine Triphosphate; Lactones; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Polymers; Pyrones; Tubulin; Tubulin Modulators | 2004 |
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Topics: Alkanes; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Epothilones; Glutathione Transferase; Histone Acetyltransferases; Humans; Immunoblotting; Lactones; Mice; Mice, Inbred C57BL; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Paclitaxel; Plasmids; Pregnane X Receptor; Pyrones; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reflex, Abnormal; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Two-Hybrid System Techniques; Xenobiotics | 2005 |
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.
Topics: 2-Methoxyestradiol; Alkaloids; Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Colchicine; Docetaxel; Down-Regulation; Epothilones; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Microtubules; Pyrones; Taxoids; Vincristine | 2005 |
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
Topics: Alkanes; Carbamates; Epothilones; Lactones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Protein Binding; Pyrones; Solutions; Tubulin | 2006 |
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Topics: Alkanes; Amino Acid Sequence; Asparagine; Binding Sites; Binding, Competitive; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Docetaxel; Epothilones; Humans; Inhibitory Concentration 50; Lactones; Mass Spectrometry; Microtubules; Models, Chemical; Models, Molecular; Molecular Sequence Data; Paclitaxel; Polycyclic Compounds; Protein Binding; Pyrones; Taxoids; Threonine; Tubulin; Tubulin Modulators | 2007 |
Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation.
Topics: Adenocarcinoma; Alkanes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Cell Survival; Dimerization; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Glycine; Humans; Lactones; Models, Molecular; Mutation, Missense; Paclitaxel; Protein Structure, Quaternary; Pyrones; Taxoids; Transfection; Tubulin; Tubulin Modulators | 2007 |
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
Topics: Alkanes; Animals; Benzimidazoles; Binding Sites; Brain Chemistry; Carbamates; Carcinoma; Cattle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Epothilones; Female; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; G2 Phase; HeLa Cells; Histones; Humans; Kinetics; Lactones; Macrolides; Microtubules; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Binding; Pyrones; Quantitative Structure-Activity Relationship; Radioligand Assay; Tubulin; Tubulin Modulators | 2008 |
Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide.
Topics: Alkanes; Animals; Biological Products; Brain; Carbamates; Cell Proliferation; Drug Combinations; Drug Synergism; Epothilones; Humans; Lactones; Microscopy, Electron; Microtubules; Nephelometry and Turbidimetry; Paclitaxel; Protein Multimerization; Protein Structure, Quaternary; Pyrones; Swine; Tubulin; Tubulin Modulators | 2009 |
Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D.
Topics: Alkanes; Alkenes; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Epothilones; Hydroxyl Radical; Lactones; Pyrones; Stereoisomerism | 2009 |
Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A.
Topics: Alkanes; Alkenes; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Epothilones; Lactones; Molecular Structure; Pyrones; Stereoisomerism | 2010 |
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells.
Topics: Acetylation; Alkanes; Antigens, Neoplasm; Carbamates; Cell Adhesion Molecules; Cell Line, Tumor; Epithelial Cell Adhesion Molecule; Epothilones; Female; Humans; Hydroxamic Acids; Lactones; Ovarian Neoplasms; Paclitaxel; Pyrones; Tubulin; Tubulin Modulators; Vinblastine | 2010 |