carbamates and discodermolide

carbamates has been researched along with discodermolide in 117 studies

Research

Studies (117)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (9.40)	18.2507
2000's	87 (74.36)	29.6817
2010's	18 (15.38)	24.3611
2020's	1 (0.85)	2.80

Authors

Authors	Studies
Caddigan, D; Gunasekera, M; Gunasekera, SP; Harmody, D; Longley, RE	2
Dumont, F; Faherty, D; Gunasekera, SP; Longley, RE; Mclane, J	1
Day, BW; Gunasekera, SP; Hamel, E; Kowalski, RJ; Lin, CM; Longley, RE; Rosenkranz, HS; ter Haar, E	1
Chen, J; Hung, DT; Schreiber, SL	1
Service, RF	1
Day, BW; Giannakakou, P; Gunasekera, SP; Hamel, E; Kowalski, RJ; Longley, RE	1
Hung, DT; Nerenberg, JB; Schreiber, SL	1
Balachandran, R; Day, BW; Grant, SG; ter Haar, E; Welsh, MJ	1
Chakravarty, S; Danishefsky, SJ; He, L; Horwitz, SB; Inoue, T; Kuduk, SD; Lin, S; Ojima, I	1
Fojo, T; Giannakakou, P	1
Arimoto, H; Danishefsky, SJ; Horwitz, SB; Kaufman, MD; Martello, LA; McDaid, HM; Meng, D; Pettus, TR; Regl, DL; Smith, AB; Yang, CP	1
Arimoto, H; Beauchamp, TJ; Kaufman, MD; LaMarche, MJ; Smith, AB	1
Sasse, F	1
Falcone-Hindley, M; LaMarche, MJ; Smith, AB	1
Gunasekera, SP; Isbrucker, RA; Longley, RE	3
Cicero, DO; Cornett, B; Monteagudo, E; Myles, DC; Snyder, JP	1
Adler, AJ; Crabtree, DV; Geng, X; Ojima, I	1
Beauchamp, TJ; He, L; Horwitz, SB; LaMarche, MJ; Martello, LA; Smith, AB	1
Florence, GJ; Gerlach, K; Paterson, I; Scott, JP; Sereinig, N	1
Arefolov, A; Langille, NF; Panek, JS	1
BouzBouz, S; Cossy, J	2
Kalesse, M	1
Chen, JG; Horwitz, SB	1
Curran, DP; Furukawa, T	1
Arefolov, A; Panek, JS	2
Paterson, I; Temal-Laïb, T	1
Bröker, LE; Ferreira, CG; Giaccone, G; Huisman, C; Kruyt, FA; Rodriguez, JA	1
Balachandran, R; Choy, N; Curran, DP; Day, BW; Madiraju, C; Shin, Y; Turner, TR	1
Delgado, O; Florence, GJ; Lyothier, I; Paterson, I; Scott, JP; Sereinig, N	1
Balachandran, R; Curran, DP; Day, BW; Giuliano, KA; Madiraju, C; Minguez, JM	1
Hu, W; Li, YZ; Zhou, L	1
Amos, LA; Florence, GJ; Kar, S; Paterson, I	1
Chen, W; Francavilla, C; Kinder, FR	1
Balachandran, R; Choy, N; Curran, DP; Day, BW; Madiraju, C; Nguyen, PQ; Shin, Y	1
Balachandran, R; Curran, DP; Day, BW; Giuliano, KA; Kim, SY; Madiraju, C; Mínguez, JM	1
Harried, SS; Lee, CP; Lee, TI; Myles, DC; Yang, G	1
Goto, F; Kiyooka, S; Okazaki, M; Shahid, KA; Shuto, Y	1
Hirose, T	2
Myles, DC	1
Braguer, D; Briand, C; Honore, S; Jordan, MA; Kamath, K; Wilson, L	1
Bröker, LE; Giaccone, G; Huisman, C; Kruyt, FA; Rodriguez, JA; Span, SW	1
Dabydeen, DA; Florence, GJ; Hamel, E; Paterson, I	1
Burlingame, MA; Hirose, T; LaMarche, MJ; Liu, F; Mendoza, E; Myles, DC; Petryka, J; Scott Freeze, B; Shaw, SJ; Smith, AB; Sundermann, KF; Zhang, D	1
Katsoulis, IA; Parker, KA	1
Daeffler, R; Gunasekera, SP; Linley, P; Mickel, SJ; Niederer, D; Pitts, T; Wright, AE	1
Colevas, D; Fojo, T; Goel, S; Macapinlac, M; Mani, S; Rothenberg, M; Verdier-Pinard, D	1
De Souza, MV	1
Braguer, D; Briand, C; Honore, S; Horwitz, SB; Jordan, MA; Kamath, K; Wilson, L	1
Mickel, SJ	1
Lyothier, I; Paterson, I	2
Delgado, O; Florence, GJ; Lyothier, I; O'Brien, M; Paterson, I; Scott, JP; Sereinig, N	1
Brouard, I; Burlingame, MA; Freeze, BS; Hirose, T; Horwitz, SB; Lamarche, MJ; Myles, DC; Rucker, PV; Shaw, SJ; Smith, AB; Sundermann, KF; Xian, M	1
Brückner, AM; Curran, DP; Kangani, CO	1
Freeze, BS; Horwitz, SB; Klein, LE; Smith, AB	1
Freeze, BS; Hirose, T; Smith, AB; Xian, M	1
Brouard, I; Burlingame, MA; Freeze, BS; Myles, DC; Shaw, SJ; Smith, AB; Sundermann, KF; Xian, M	1
Freeze, BS; Kinzler, KW; LaMarche, MJ; Sager, J; Smith, AB; Vogelstein, B	1
Horwitz, SB; Huang, H; Kalpana, G; Liu, W; Mani, S; Smith, AB; Sundarababu, S	1
Escuin, D; Giannakakou, P; Kline, ER	1
Liu, F; Smith, AB; Xian, M	1
Anderson, EA; Paterson, I	1
Brouard, I; Freeze, BS; Horwitz, SB; Rucker, PV; Smith, AB; Xia, S	1
Smith, AB; Xian, M	1
Balachandran, R; Brückner, AM; Curran, DP; Day, BW; Edler, MC; Fournier, JH; Fukui, Y; Giuliano, KA; Hamel, E; Madiraju, C; Raccor, BS; Shin, Y; Vogt, A; Zhu, G	1
Freeze, BS; Goldberg, GL; Horwitz, SB; Huang, GS; Lopez-Barcons, L; McDaid, HM; Smith, AB	1
Bergstralh, DT; Ting, JP	1
Cao, H; Parker, KA	2
Horwitz, SB; Kenesky, CS; Orr, GA; Rucker, PV; Smith, AB; Xia, S	1
De Voss, J	1
Carlomagno, T; Kubicek, K; Lyothier, I; Meiler, J; Paterson, I; Sánchez-Pedregal, VM	1
Andreu, JM; Barasoain, I; Buey, RM; Calvo, E; Cerezo, G; Day, BW; Díaz, JF; Edler, MC; Hamel, E; López, JA; Matesanz, R; Pineda, O; Sorensen, EJ; Vanderwal, CD	1
Ardisson, J; Betzer, JF; Commerçon, A; de Lemos, E; Pancrazi, A; Porée, FH	1
Morris, JC; Nicholas, GM; Phillips, AJ	1
Gardner, NM; Paterson, I	1
Menzella, HG; Myles, DC; Shaw, SJ; Smith, AB; Xian, M	1
Horwitz, SB; Wiesen, KM; Xia, S; Yang, CP	1
Parker, KA; Wang, P	1
Balachandran, R; Curran, DP; Day, BW; Fukui, Y; Jung, WH; Madiraju, C; Montgomery, K; Raccor, BS; Shin, Y; Sikorski, RP; Vogt, A	1
Mooberry, SL	1
Shaw, SJ	1
Florence, GJ; Gardner, NM; Paterson, I	1
Andreu, JM; Canales, A; Díaz, JF; Gardner, NM; Jiménez-Barbero, J; Matesanz, R; Paterson, I	1
Naylor, GJ; Paterson, I; Wright, AE	1
Gardner, NM; Guzmán, E; Paterson, I; Wright, AE	1
Agouridas, E; Ardisson, J; Barbion, J; Betzer, JF; Bourin, A; Commerçon, A; de Lemos, E; Lannou, MI; Pancrazi, A; Porée, FH	1
Altmann, KH; Gertsch, J; Meier, S; Müller, M	1
Fuchs, PL; Mollat du Jourdin, X; Noshi, M	1
Mulzer, J; Prantz, K	2
Day, BW; Fan, Y; Schreiber, EM	1
Angeletti, RH; Fiser, A; Horwitz, SB; Khrapunovich-Baine, M; Menon, V; Smith, AB; Verdier-Pinard, P; Xiao, H	1
Cicero, D; Cornett, B; Jogalekar, AS; Kriel, FH; Shi, Q; Snyder, JP	1
Fujita, T; Guzmán, E; Naylor, GJ; Paterson, I; Wright, AE	1
Gorman, T; Jarrard, J; Manning, TJ; Williams, J	1
Castellanos, L; Valderrama, K; Zea, S	1
Vollmar, AM; von Schwarzenberg, K	1
Goldberg, GL; Horwitz, SB; Shahabi, S; Yang, CP	1
Brouwer-Visser, J; Chao, SK; Horwitz, SB; Lin, J; McDaid, HM; Smith, AB	1
Gardner, NM; Guzmán, E; Naylor, GJ; Paterson, I; Wright, AE	1
Andreu, JM; Canales, A; Coderch, C; Díaz, JF; Jiménez-Barbero, J; Nieto, L; Paterson, I; Rodríguez-Salarichs, J; Trigili, C	1
Agouridas, E; Ardisson, J; Betzer, JF; Commerçon, A; de Lemos, E; Guerreiro, A; Lannou, MI; Pancrazi, A; Sorin, G	1
Bane, S; Blanden, AR; Kingston, DG; Qi, J	1
Atasoylu, O; Horwitz, SB; Smith, AB; Sugasawa, K; Yang, CP	1
Castellanos, L; Ruiz, C; Valderrama, K; Zea, S	1
Ely, RJ; Morken, JP; Yu, Z	1
Goldman, ID; Horwitz, SB	1
Bargsten, K; Fernando Díaz, J; Horwitz, SB; McDaid, HM; Paterson, I; Prota, AE; Redondo-Horcajo, M; Smith, AB; Steinmetz, MO; Yang, CH	1
Atasoylu, O; Horwitz, SB; McDaid, HM; Nadaradjane, C; Rodriguez-Gabin, A; Smith, AB; Sugasawa, K; Yang, CH; Ye, K	1
Guo, B; Horwitz, SB; McDaid, HM; Mühlethaler, T; Prota, AE; Rodriguez-Gabin, A; Smith, AB; Steinmetz, MO; Ye, K; Zhang, N	1

Reviews

13 review(s) available for carbamates and discodermolide

Article	Year
Immunosuppression by discodermolide. Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 696 Topics: Alkanes; Animals; Carbamates; Cell Cycle; Cell Line; Doxorubicin; Humans; Immunosuppressive Agents; Lactones; Lymphocyte Activation; Mice; Pyrones	1993
The chemistry and biology of discodermolide. Chembiochem : a European journal of chemical biology, 2000, Oct-02, Volume: 1, Issue:3 Topics: Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carbamates; Lactones; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Stereoisomerism	2000
[Natural anti-tumor compounds with activity of promoting microtubule assembly]. Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:2 Topics: Alkaloids; Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carbamates; Diterpenes; Lactones; Macrolides; Materia Medica; Microtubules; Molecular Structure; Paclitaxel; Pyrones; Structure-Activity Relationship; Taxoids	2001
Novel biologically active natural and unnatural products. Current opinion in biotechnology, 2003, Volume: 14, Issue:6 Topics: Alkanes; Antifungal Agents; Carbamates; Epothilones; Erythromycin; Furans; Gram-Positive Bacteria; Lactones; Lipids; Macrolides; Models, Chemical; Pyrones; Structure-Activity Relationship; Taxoids	2003
The clinical development of new mitotic inhibitors that stabilize the microtubule. Anti-cancer drugs, 2004, Volume: 15, Issue:6 Topics: Alkanes; Animals; Carbamates; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drug Screening Assays, Antitumor; Epothilones; Humans; Lactones; Microtubule-Associated Proteins; Microtubules; Mitosis; Molecular Structure; Multicenter Studies as Topic; Pyrones	2004
(+)-discodermolide: a marine natural product against cancer. TheScientificWorldJournal, 2004, Jun-11, Volume: 4 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lactones; Molecular Conformation; Molecular Structure; Porifera; Pyrones; Stereoisomerism; Structure-Activity Relationship	2004
Toward a commercial synthesis of (+)-discodermolide. Current opinion in drug discovery & development, 2004, Volume: 7, Issue:6 Topics: Alkanes; Alkylating Agents; Animals; Antineoplastic Agents; Carbamates; Crystallography, X-Ray; Humans; Immunosuppressive Agents; Indicators and Reagents; Lactones; Organometallic Compounds; Pyrones	2004
Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combination. Cancer treatment reviews, 2006, Volume: 32, Issue:3 Topics: Alkanes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Cyclooxygenase 2; Diterpenes; Epothilones; Humans; Inhibitor of Apoptosis Proteins; Interleukin-1; Interleukin-8; Lactones; Macrolides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Maturation-Promoting Factor; Microtubule-Associated Proteins; Microtubules; Neoplasm Proteins; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrones; Signal Transduction; Survivin; Taxoids; Tumor Suppressor Protein p53	2006
Marine natural products: synthetic aspects. Natural product reports, 2007, Volume: 24, Issue:1 Topics: Alkaloids; Alkanes; Biological Products; Carbamates; Ethers; Guanidine; Guanidines; Lactones; Macrolides; Marine Biology; Molecular Structure; Pyrones; Spiro Compounds	2007
Strategies for the development of novel Taxol-like agents. Methods in molecular medicine, 2007, Volume: 137 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Docetaxel; Drug Design; Drug Resistance, Neoplasm; Epothilones; Humans; Lactones; Microtubules; Paclitaxel; Pyrones; Taxoids	2007
The structure activity relationship of discodermolide analogues. Mini reviews in medicinal chemistry, 2008, Volume: 8, Issue:3 Topics: Alkanes; Animals; Carbamates; Humans; Lactones; Macrolides; Pyrones; Structure-Activity Relationship	2008
Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin. Natural product reports, 2008, Volume: 25, Issue:2 Topics: Alkanes; Antineoplastic Agents; Carbamates; Lactones; Macrolides; Marine Biology; Molecular Structure; Pyrones	2008
Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy. Cancer letters, 2013, May-28, Volume: 332, Issue:2 Topics: Alkaloids; Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Aquatic Organisms; Biological Products; Bryostatins; Carbamates; Cell Proliferation; Depsipeptides; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Microtubules; Models, Chemical; Neoplasms; Phenanthrolines; Phenazines; Proteasome Endopeptidase Complex; Pyrones; Pyrroles; Quinolines; Spiro Compounds; Steroids; Tetrahydroisoquinolines; Thiazoles; Trabectedin	2013

Other Studies

104 other study(ies) available for carbamates and discodermolide

Article	Year
Discodermolide--a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation, 1991, Volume: 52, Issue:4 Topics: Alkanes; Animals; Carbamates; Cells, Cultured; Concanavalin A; Female; Humans; Immunosuppressive Agents; Interleukin-2; Ionomycin; Lactones; Leukocytes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrones; Receptors, Interleukin-2; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate	1991
Discodermolide--a new, marine-derived immunosuppressive compound. II. In vivo studies. Transplantation, 1991, Volume: 52, Issue:4 Topics: Alkanes; Animals; Antibody Formation; Carbamates; Concanavalin A; Cyclosporine; Graft vs Host Reaction; Immunosuppressive Agents; Interleukin-2; Killer Cells, Natural; Lactones; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Pyrones; Spleen; T-Lymphocytes	1991
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 1996, Jan-09, Volume: 35, Issue:1 Topics: Alkanes; Animals; Antineoplastic Agents; Breast Neoplasms; Burkitt Lymphoma; Calcium; Carbamates; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique, Indirect; Guanosine Triphosphate; Humans; Kinetics; Lactones; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Porifera; Pyrones; Time Factors; Tubulin; Tumor Cells, Cultured	1996
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chemistry & biology, 1996, Volume: 3, Issue:4 Topics: 3T3 Cells; Alkanes; Animals; Binding Sites; Carbamates; Cell Line; Humans; Lactones; Mice; Microtubules; Mitosis; Paclitaxel; Pyrones	1996
Tumor-killer made; how does it work? Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295 Topics: Alkanes; Antineoplastic Agents; Carbamates; Computer Simulation; Epothilones; Epoxy Compounds; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	1996
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Molecular pharmacology, 1997, Volume: 52, Issue:4 Topics: Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding, Competitive; Carbamates; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique, Indirect; Humans; Lactones; Microscopy, Electron; Microtubules; Ovarian Neoplasms; Paclitaxel; Pyrones; Rats; Tubulin; Tumor Cells, Cultured	1997
Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chemistry & biology, 1994, Volume: 1, Issue:1 Topics: Alkanes; Animals; Carbamates; Cell Cycle; Cell Membrane Permeability; Humans; Immunosuppressive Agents; Lactones; Mice; Pyrones; Tumor Cells, Cultured	1994
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel. Anti-cancer drugs, 1998, Volume: 9, Issue:1 Topics: Alkanes; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carbamates; Diploidy; DNA Fragmentation; DNA, Neoplasm; Female; Humans; Lactones; Paclitaxel; Pyrones; Tumor Cells, Cultured	1998
A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proceedings of the National Academy of Sciences of the United States of America, 1999, Apr-13, Volume: 96, Issue:8 Topics: Alkaloids; Alkanes; Antineoplastic Agents, Phytogenic; Carbamates; Computer Graphics; Diterpenes; Epothilones; Epoxy Compounds; Lactones; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Molecular Conformation; Molecular Structure; Paclitaxel; Pyrones; Thiazoles	1999
Discodermolide: just another microtubule-stabilizing agent? No! A lesson in synergy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Synergism; Humans; Lactones; Lung Neoplasms; Microtubules; Paclitaxel; Pyrones; Tumor Cells, Cultured	2000
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carbamates; Cell Count; Cell Division; Cell Line; Cytoskeleton; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epothilones; Epoxy Compounds; Flow Cytometry; Humans; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones; Thiazoles; Tumor Cells, Cultured	2000
Gram-scale synthesis of (+)-discodermolide. Organic letters, 1999, Dec-02, Volume: 1, Issue:11 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Indicators and Reagents; Lactones; Porifera; Pyrones; Stereoisomerism	1999
Microtubule bundling. Current biology : CB, 2000, Jun-29, Volume: 10, Issue:13 Topics: Actins; Alkanes; Animals; Carbamates; Cell Line, Transformed; Fibroblasts; Fluorescent Antibody Technique; Lactones; Mice; Microtubules; Pyrones	2000
Solution structure of (+)-discodermolide. Organic letters, 2001, Mar-08, Volume: 3, Issue:5 Topics: Alkanes; Animals; Carbamates; Immunosuppressive Agents; Lactones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Monte Carlo Method; Porifera; Pyrones; Solutions; Tubulin	2001
Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity. Journal of natural products, 2001, Volume: 64, Issue:2 Topics: Acetylation; Alkanes; Animals; Antineoplastic Agents; Carbamates; Lactones; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Microtubules; Models, Chemical; Porifera; Pyrones	2001
The conformations of discodermolide in DMSO. Journal of the American Chemical Society, 2001, Jul-18, Volume: 123, Issue:28 Topics: Alkanes; Animals; Carbamates; Dimethyl Sulfoxide; Humans; Lactones; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Porifera; Pyrones; Solutions	2001
Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity. Cancer chemotherapy and pharmacology, 2001, Volume: 48, Issue:1 Topics: Acetylation; Alkanes; Animals; Antineoplastic Agents; Carbamates; Cattle; Lactones; Microtubules; Pyrones; Structure-Activity Relationship; Tubulin	2001
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:8 Topics: Alkaloids; Alkanes; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Carbamates; Carotenoids; Diterpenes; Epothilones; Epoxy Compounds; Haplorhini; Humans; Lactones; Ligands; Lutein; Models, Molecular; Molecular Sequence Data; Paclitaxel; Pyrones; Retina; Thiazoles; Tubulin	2001
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & biology, 2001, Volume: 8, Issue:9 Topics: Alkanes; Antineoplastic Agents, Phytogenic; Binding, Competitive; Carbamates; Flow Cytometry; Humans; Inhibitory Concentration 50; Lactones; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Models, Molecular; Paclitaxel; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2001
A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions. Journal of the American Chemical Society, 2001, Oct-03, Volume: 123, Issue:39 Topics: Aldehydes; Alkanes; Antineoplastic Agents; Carbamates; Immunosuppressive Agents; Lactones; Pyrones; Stereoisomerism	2001
Stereoselective synthesis of functionalized trisubstituted olefins via palladium(0)-catalyzed cross-coupling reaction. Organic letters, 2001, Oct-18, Volume: 3, Issue:21 Topics: Alkanes; Alkenes; Carbamates; Catalysis; Fatty Acids, Unsaturated; Iodine; Lactones; Models, Molecular; Palladium; Pyrones; Silanes; Stereoisomerism; Zirconium	2001
Efficient strategy for the synthesis of stereopentad subunits of scytophycin, rifamycin S, and discodermolide. Organic letters, 2001, Dec-13, Volume: 3, Issue:25 Topics: Aldehydes; Alkanes; Antineoplastic Agents; Carbamates; Lactones; Molecular Conformation; Molecular Structure; Pyrans; Pyrones; Rifamycins; Stereoisomerism	2001
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer research, 2002, Apr-01, Volume: 62, Issue:7 Topics: Alkanes; Aneuploidy; Antineoplastic Agents; Carbamates; Carcinoma, Non-Small-Cell Lung; Epothilones; Humans; Lactones; Lung Neoplasms; Macrolides; Microtubules; Mitosis; Paclitaxel; Pyrones; Spindle Apparatus; Tumor Cells, Cultured	2002
Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis. Organic letters, 2002, Jun-27, Volume: 4, Issue:13 Topics: Alkanes; Antineoplastic Agents; Carbamates; Chromatography; Fluorine; Hydrocarbons, Fluorinated; Lactones; Pyrones	2002
Studies directed toward the total synthesis of discodermolide: asymmetric synthesis of the C1-C14 fragment. Organic letters, 2002, Jul-11, Volume: 4, Issue:14 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Indicators and Reagents; Lactones; Porifera; Pyrones; Stereoisomerism	2002
Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. Organic letters, 2002, Jul-25, Volume: 4, Issue:15 Topics: Acetals; Aldehydes; Alkanes; Carbamates; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Erythromycin; Ketones; Lactones; Polymers; Pyrones; Stereoisomerism	2002
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells. Cancer research, 2002, Jul-15, Volume: 62, Issue:14 Topics: Alkanes; Antineoplastic Agents; Apoptosis; Carbamates; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Caspases; Epothilones; Humans; Inhibitory Concentration 50; Jurkat Cells; Lactones; Lung Neoplasms; Macrolides; Mitochondria; Pyrones; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured	2002
Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation. Organic letters, 2002, Dec-12, Volume: 4, Issue:25 Topics: Alkanes; Antineoplastic Agents; Breast Neoplasms; Carbamates; Female; Humans; Lactones; Macrolides; Ovarian Neoplasms; Pyrones; Tumor Cells, Cultured	2002
Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity. Journal of natural products, 2002, Volume: 65, Issue:12 Topics: Adenocarcinoma; Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia P388; Mice; Microtubules; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Porifera; Pyrones; Structure-Activity Relationship; Tumor Cells, Cultured	2002
1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide. Organic letters, 2003, Jan-09, Volume: 5, Issue:1 Topics: Alkanes; Animals; Antineoplastic Agents; Boron; Carbamates; Lactones; Molecular Structure; Porifera; Pyrones	2003
Synthesis and high content cell-based profiling of simplified analogues of the microtubule stabilizer (+)-discodermolide. Molecular cancer therapeutics, 2002, Volume: 1, Issue:14 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Carbon; Carcinoma; Cell Division; Dose-Response Relationship, Drug; Gene Library; HeLa Cells; Humans; Lactones; Microtubules; Models, Chemical; Paclitaxel; Phosphorylation; Pyrones; Signal Transduction; Spindle Apparatus; Tubulin; Tumor Cells, Cultured	2002
Discodermolide interferes with the binding of tau protein to microtubules. FEBS letters, 2003, Mar-27, Volume: 539, Issue:1-3 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; In Vitro Techniques; Lactones; Microtubules; Protein Binding; Pyrones; Swine; tau Proteins; Tubulin	2003
Formal synthesis of (+)-discodermolide. Organic letters, 2003, Apr-17, Volume: 5, Issue:8 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Lactones; Porifera; Pyrones; Stereoisomerism	2003
Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Alkanes; Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Carbamates; Cattle; Cell Division; Crystallography, X-Ray; Lactones; Microtubules; Paclitaxel; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin	2003
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide. Bioorganic & medicinal chemistry, 2003, Jul-31, Volume: 11, Issue:15 Topics: Alkanes; Carbamates; Cell Line, Tumor; Humans; Lactones; Microtubules; Pyrones	2003
Stereoselective synthesis of the C1-C13 fragment of (+)-discodermolide using asymmetric allyltitanations. Organic letters, 2003, Aug-21, Volume: 5, Issue:17 Topics: Aldehydes; Alkanes; Alkenes; Animals; Carbamates; Lactones; Porifera; Pyrones; Stereoisomerism	2003
Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide. The Journal of organic chemistry, 2003, Aug-22, Volume: 68, Issue:17 Topics: Alkanes; Alkylation; Antineoplastic Agents; Carbamates; Indicators and Reagents; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Pyrones	2003
Regulated-stereoselective construction of thirteen stereogenic centers necessary for the frame of (+)-discodermolide, based on iterative Lewis acid-promoted aldol reactions. The Journal of organic chemistry, 2003, Oct-17, Volume: 68, Issue:21 Topics: Aldehydes; Alkanes; Antineoplastic Agents; Carbamates; Lactones; Molecular Structure; Propionates; Pyrones; Stereoisomerism	2003
[Synthesis of architectural complex natural products, potent, antibacterial and anticancer activity]. The Japanese journal of antibiotics, 2003, Volume: 56, Issue:4 Topics: Alkanes; Animals; Antineoplastic Agents; Biological Products; Carbamates; Heterocyclic Compounds, 4 or More Rings; Lactones; Oxazoles; Pyrones; Saccharomyces	2003
Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. Molecular cancer therapeutics, 2003, Volume: 2, Issue:12 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Division; Cell Line, Tumor; Epothilones; Humans; Lactones; Microtubules; Mitosis; Paclitaxel; Pyrones	2003
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. Cancer research, 2004, Jan-01, Volume: 64, Issue:1 Topics: Alkanes; Antineoplastic Agents; Apoptosis; Base Sequence; Carbamates; Carcinoma, Non-Small-Cell Lung; Caspases; Cathepsin B; Cell Death; DNA Primers; Epothilones; Humans; Lactones; Lung Neoplasms; Lysosomes; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pyrones; Transfection; Tumor Cells, Cultured	2004
A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel. Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:5 Topics: Alkanes; Carbamates; Dose-Response Relationship, Drug; Epothilones; Guanosine Triphosphate; Lactones; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Polymers; Pyrones; Tubulin; Tubulin Modulators	2004
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Humans; Lactones; Pyrones	2004
A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide. Organic letters, 2004, Apr-29, Volume: 6, Issue:9 Topics: Alkanes; Carbamates; Lactones; Models, Molecular; Molecular Conformation; Pyrones; Stereoisomerism	2004
Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity. Journal of natural products, 2004, Volume: 67, Issue:5 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia P388; Mice; Microtubules; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2004
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer research, 2004, Jul-15, Volume: 64, Issue:14 Topics: Alkanes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Carbamates; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Synergism; G2 Phase; Humans; Inhibitory Concentration 50; Lactones; Lung Neoplasms; Microtubules; Mitosis; Paclitaxel; Pyrones	2004
Total synthesis of (+)-discodermolide: an improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 beta-ketophosphonate fragment. Organic letters, 2004, Dec-23, Volume: 6, Issue:26 Topics: Aldehydes; Alkanes; Alkenes; Carbamates; Ketones; Lactones; Molecular Conformation; Organophosphonates; Pyrones; Stereoisomerism	2004
A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol. The Journal of organic chemistry, 2005, Jan-07, Volume: 70, Issue:1 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Combinatorial Chemistry Techniques; Indicators and Reagents; Lactones; Molecular Structure; Porifera; Pyrones; Stereoisomerism	2005
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. Organic letters, 2005, Jan-20, Volume: 7, Issue:2 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lactones; Molecular Structure; Pyrones; Structure-Activity Relationship	2005
Ring-closing metathesis approach to dictyostatin. Organic letters, 2005, Feb-03, Volume: 7, Issue:3 Topics: Alkanes; Carbamates; Esters; Indicators and Reagents; Lactones; Macrolides; Molecular Conformation; Oxidation-Reduction; Pyrones; Structure-Activity Relationship	2005
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:3 Topics: Alkanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bromodeoxyuridine; Carbamates; Cell Line, Tumor; Cellular Senescence; Flow Cytometry; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Lactones; Microtubules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitosis; Paclitaxel; Phenotype; Pyrones; Signal Transduction; Time Factors	2005
Crotylsilane reagents in the synthesis of complex polyketide natural products: total synthesis of (+)-discodermolide. Journal of the American Chemical Society, 2005, Apr-20, Volume: 127, Issue:15 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Lactones; Porifera; Pyrones; Silanes; Stereoisomerism	2005
Total synthesis of (+)-discodermolide: a highly convergent fourth-generation approach. Organic letters, 2005, Apr-28, Volume: 7, Issue:9 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Lactones; Molecular Structure; Porifera; Pyrones; Stereoisomerism	2005
Toward understanding how the lactone moiety of discodermolide affects activity. Journal of the American Chemical Society, 2005, May-11, Volume: 127, Issue:18 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lactones; Molecular Conformation; Pyrones; Stereoisomerism; Structure-Activity Relationship	2005
Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15 Topics: Alkanes; Animals; Antineoplastic Agents; Bacterial Toxins; Binding Sites; Carbamates; Colorectal Neoplasms; Combined Modality Therapy; Injections, Intravenous; Lactones; Mice; Microtubules; Molecular Structure; Pyrones; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured	2005
Development of a third-generation total synthesis of (+)-discodermolide: an expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate. The Journal of organic chemistry, 2005, Jul-08, Volume: 70, Issue:14 Topics: Aldehydes; Alkanes; Antineoplastic Agents; Boron; Carbamates; Ketones; Lactones; Models, Chemical; Organophosphonates; Oxidation-Reduction; Pyrones; Stereoisomerism	2005
[Synthesis of architectural complex natural products, potent, antibacterial and anticancer activity]. The Japanese journal of antibiotics, 2005, Volume: 58, Issue:2 Topics: Alkanes; Antineoplastic Agents; Carbamates; Lactones; Pyrones	2005
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Sep-01, Volume: 11, Issue:17 Topics: Alkanes; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Epothilones; Glutathione Transferase; Histone Acetyltransferases; Humans; Immunoblotting; Lactones; Mice; Mice, Inbred C57BL; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Paclitaxel; Plasmids; Pregnane X Receptor; Pyrones; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reflex, Abnormal; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Two-Hybrid System Techniques; Xenobiotics	2005
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer research, 2005, Oct-01, Volume: 65, Issue:19 Topics: 2-Methoxyestradiol; Alkaloids; Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Colchicine; Docetaxel; Down-Regulation; Epothilones; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Microtubules; Pyrones; Taxoids; Vincristine	2005
Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide. Organic letters, 2005, Oct-13, Volume: 7, Issue:21 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Survival; Cyclopropanes; Drug Design; Humans; Lactones; Molecular Structure; Pyrones; Stereoisomerism; Structure-Activity Relationship	2005
Chemistry. The renaissance of natural products as drug candidates. Science (New York, N.Y.), 2005, Oct-21, Volume: 310, Issue:5747 Topics: Alkanes; Anti-Infective Agents; Antineoplastic Agents; Biological Products; Bryostatins; Carbamates; Clinical Trials as Topic; Combinatorial Chemistry Techniques; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Evolution, Molecular; Furans; Genetic Engineering; Ketones; Lactones; Macrolides; Molecular Structure; Pyrones; Structure-Activity Relationship	2005
Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes. Organic letters, 2005, Nov-10, Volume: 7, Issue:23 Topics: Alkanes; Benzophenones; Carbamates; Fluorescent Dyes; Lactones; Molecular Probes; Molecular Structure; Photoaffinity Labels; Pyrones; Stereoisomerism	2005
Design, synthesis, and biological evaluation of simplified analogues of (+)-discodermolide. Additional insights on the importance of the diene, the C7 hydroxyl, and the lactone. Organic letters, 2005, Nov-10, Volume: 7, Issue:23 Topics: Alkanes; Antineoplastic Agents; Carbamates; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Lactones; Molecular Structure; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2005
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry, 2005, Nov-15, Volume: 44, Issue:45 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Cell Line, Tumor; Cell Proliferation; Humans; Lactones; Macrolides; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pyrones; Tubulin	2005
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jan-01, Volume: 12, Issue:1 Topics: Alkanes; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Caspases; Cell Cycle; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Female; Humans; Immunohistochemistry; Lactones; Mice; Neovascularization, Pathologic; Ovarian Neoplasms; Paclitaxel; Platelet Endothelial Cell Adhesion Molecule-1; Pyrones; Xenograft Model Antitumor Assays	2006
Scalable, catalytic asymmetric synthesis of syn, anti stereotriad building blocks for polypropionate antibiotics. Organic letters, 2006, Aug-03, Volume: 8, Issue:16 Topics: Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carbamates; Catalysis; Lactones; Molecular Structure; Porifera; Pyrones; Stereoisomerism	2006
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin. Biochemistry, 2006, Oct-03, Volume: 45, Issue:39 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Division; G2 Phase; Humans; Lactones; Microtubules; Models, Molecular; Paclitaxel; Peptides; Photoaffinity Labels; Protein Binding; Protein Structure, Tertiary; Pyrones; Tubulin	2006
Biodiversity and natural products - IUPAC International Conference (ICOB-5 and ISCNP-25). IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:10 Topics: Actinobacteria; Alkanes; Anti-Bacterial Agents; Biodiversity; Carbamates; Crotalid Venoms; Ethers, Cyclic; Lactones; Macrolides; Protease Inhibitors; Pyrones; Receptors, Cytoplasmic and Nuclear	2006
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. Angewandte Chemie (International ed. in English), 2006, Nov-13, Volume: 45, Issue:44 Topics: Alkanes; Carbamates; Epothilones; Lactones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Protein Binding; Pyrones; Solutions; Tubulin	2006
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature chemical biology, 2007, Volume: 3, Issue:2 Topics: Alkanes; Amino Acid Sequence; Asparagine; Binding Sites; Binding, Competitive; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Docetaxel; Epothilones; Humans; Inhibitory Concentration 50; Lactones; Mass Spectrometry; Microtubules; Models, Chemical; Models, Molecular; Molecular Sequence Data; Paclitaxel; Polycyclic Compounds; Protein Binding; Pyrones; Taxoids; Threonine; Tubulin; Tubulin Modulators	2007
alpha-Oxygenated crotyltitanium and dyotropic rearrangement in the total synthesis of discodermolide. Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:11 Topics: Alkanes; Allyl Compounds; Animals; Antineoplastic Agents; Carbamates; Indicators and Reagents; Lactones; Magnetic Resonance Spectroscopy; Organometallic Compounds; Oxidation-Reduction; Porifera; Pyrones; Stereoisomerism; Titanium	2007
Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid. Chemical communications (Cambridge, England), 2007, Jan-07, Issue:1 Topics: Alkanes; Carbamates; Cell Line, Tumor; Cell Proliferation; Humans; Lactones; Macrocyclic Compounds; Macrolides; Models, Molecular; Molecular Structure; Pyrones	2007
Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region. Organic & biomolecular chemistry, 2007, Sep-07, Volume: 5, Issue:17 Topics: Alkanes; Biological Products; Carbamates; Cell Line, Tumor; Cell Proliferation; Coumarins; Humans; Lactones; Molecular Structure; Pyrones	2007
Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation. Cancer letters, 2007, Nov-18, Volume: 257, Issue:2 Topics: Adenocarcinoma; Alkanes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Cell Survival; Dimerization; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Glycine; Humans; Lactones; Models, Molecular; Mutation, Missense; Paclitaxel; Protein Structure, Quaternary; Pyrones; Taxoids; Transfection; Tubulin; Tubulin Modulators	2007
Deconstruction-reconstruction strategy for accessing valuable polyketides. Preparation of the C15-C24 stereopentad of discodermolide. Organic letters, 2007, Nov-08, Volume: 9, Issue:23 Topics: Alkanes; Carbamates; Carbon; Lactones; Macrolides; Molecular Structure; Oleandomycin; Pyrones; Stereoisomerism	2007
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin. Molecular pharmacology, 2008, Volume: 73, Issue:3 Topics: Alkanes; Animals; Benzimidazoles; Binding Sites; Brain Chemistry; Carbamates; Carcinoma; Cattle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Epothilones; Female; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; G2 Phase; HeLa Cells; Histones; Humans; Kinetics; Lactones; Macrolides; Microtubules; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Binding; Pyrones; Quantitative Structure-Activity Relationship; Radioligand Assay; Tubulin; Tubulin Modulators	2008
Short synthesis of the C1-C14 stretch of discodermolide from building blocks prepared by asymmetric catalysis. Organic letters, 2008, Apr-03, Volume: 10, Issue:7 Topics: Alkanes; Carbamates; Catalysis; Lactones; Molecular Structure; Pyrones; Stereoisomerism	2008
The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin. Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:25 Topics: Alkanes; Carbamates; Computer Simulation; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Microtubules; Molecular Conformation; Pyrones; Reference Standards; Reproducibility of Results; Solutions; Water	2008
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chemical communications (Cambridge, England), 2008, Oct-14, Issue:38 Topics: Alkanes; Antineoplastic Agents; Biological Products; Carbamates; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Humans; Lactones; Macrolides; Paclitaxel; Pyrones	2008
Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Molecular Structure; Paclitaxel; Porifera; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin	2008
Total synthesis of discodermolide: optimization of the effective synthetic route. Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:35 Topics: Alcohols; Alkanes; Alkenes; Antineoplastic Agents; Carbamates; Lactones; Pyrones; Tubulin Modulators	2008
Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. Chembiochem : a European journal of chemical biology, 2009, Jan-05, Volume: 10, Issue:1 Topics: Alkanes; Animals; Biological Products; Brain; Carbamates; Cell Proliferation; Drug Combinations; Drug Synergism; Epothilones; Humans; Lactones; Microscopy, Electron; Microtubules; Nephelometry and Turbidimetry; Paclitaxel; Protein Multimerization; Protein Structure, Quaternary; Pyrones; Swine; Tubulin; Tubulin Modulators	2009
Designer discodermolide segments via ozonolysis of vinyl phosphonates. Organic letters, 2009, Feb-05, Volume: 11, Issue:3 Topics: Alkanes; Carbamates; Combinatorial Chemistry Techniques; Lactones; Models, Molecular; Molecular Structure; Organophosphonates; Oxidation-Reduction; Ozone; Pyrones; Structure-Activity Relationship; Sulfones; Vinyl Compounds	2009
Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:27 Topics: Alkanes; Alkenes; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Epothilones; Hydroxyl Radical; Lactones; Pyrones; Stereoisomerism	2009
Human liver microsomal metabolism of (+)-discodermolide. Journal of natural products, 2009, Volume: 72, Issue:10 Topics: Alkanes; Animals; Carbamates; Chromatography, Liquid; Humans; Lactones; Microsomes, Liver; Molecular Structure; Porifera; Pyrones; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism	2009
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. Biochemistry, 2009, Dec-15, Volume: 48, Issue:49 Topics: Alkanes; Animals; Binding Sites; Carbamates; Cattle; Chickens; Deuterium Exchange Measurement; Dimerization; Drug Synergism; Lactones; Microtubules; Paclitaxel; Peptide Fragments; Protein Binding; Protein Isoforms; Protein Stability; Pyrones; Tubulin; Tubulin Modulators	2009
The discodermolide hairpin structure flows from conformationally stable modular motifs. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Alkanes; Amino Acid Motifs; Animals; Carbamates; Computer Simulation; Crystallography, X-Ray; Lactones; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Porifera; Pyrones; Quantum Theory; Structure-Activity Relationship; Tubulin	2010
Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Jan-11, Volume: 16, Issue:2 Topics: Alkanes; Alkenes; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Epothilones; Lactones; Molecular Structure; Pyrones; Stereoisomerism	2010
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin. Chemical communications (Cambridge, England), 2010, Jan-14, Volume: 46, Issue:2 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Humans; Lactones; Macrolides; Microtubules; Paclitaxel; Pyrones; Tubulin Modulators	2010
Iron complexation to oxygen rich marine natural products: a computational study. Marine drugs, 2010, Jan-04, Volume: 8, Issue:1 Topics: Alkanes; Animals; Antineoplastic Agents; Biological Products; Carbamates; Cell Line, Tumor; Chemical Phenomena; Computational Biology; Depsipeptides; Ethers, Cyclic; Humans; Inhibitory Concentration 50; Iron; Lactones; Macrolides; Models, Molecular; Molecular Conformation; Neoplasms; Oxygen; Pyrones; Siderophores; Structure-Activity Relationship	2010
Validation and evaluation of an HPLC methodology for the quantification of the potent antimitotic compound (+)-discodermolide in the Caribbean marine sponge Discodermia dissoluta. Journal of separation science, 2010, Volume: 33, Issue:15 Topics: Alkanes; Animals; Carbamates; Chromatography, High Pressure Liquid; Lactones; Molecular Conformation; Porifera; Pyrones; Spectrophotometry, Ultraviolet; Stereoisomerism	2010
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. Gynecologic oncology, 2010, Volume: 119, Issue:2 Topics: Acetylation; Alkanes; Antigens, Neoplasm; Carbamates; Cell Adhesion Molecules; Cell Line, Tumor; Epithelial Cell Adhesion Molecule; Epothilones; Female; Humans; Hydroxamic Acids; Lactones; Ovarian Neoplasms; Paclitaxel; Pyrones; Tubulin; Tubulin Modulators; Vinblastine	2010
Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-04, Volume: 108, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Alkanes; Animals; Antineoplastic Agents; beta-Galactosidase; Carbamates; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Genetic Vectors; Humans; Immunoblotting; Immunohistochemistry; Lactones; Lentivirus; Mice; Microarray Analysis; Paclitaxel; Phosphoproteins; Pyrones; Transduction, Genetic; Tubulin Modulators; Tumor Suppressor Protein p53	2011
Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol. Chemistry, an Asian journal, 2011, Feb-01, Volume: 6, Issue:2 Topics: Alkanes; Antimitotic Agents; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Neoplasms; Paclitaxel; Pyrones	2011
Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach. ACS chemical biology, 2011, Aug-19, Volume: 6, Issue:8 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Computer Simulation; Docetaxel; Humans; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel; Protein Multimerization; Pyrones; Taxoids; Tubulin; Tubulin Modulators	2011
Conception, synthesis, and biological evaluation of original discodermolide analogues. Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Aug-29, Volume: 17, Issue:36 Topics: Alkanes; Carbamates; Lactones; Pyrones	2011
Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin. Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17 Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Design; Fluorescent Dyes; Humans; Lactones; Paclitaxel; Protein Binding; Pyrones; Tubulin	2011
Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity. Journal of medicinal chemistry, 2011, Sep-22, Volume: 54, Issue:18 Topics: Alkanes; Antineoplastic Agents; Binding Sites; Carbamates; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Lactones; Microtubules; Models, Molecular; Molecular Conformation; Paclitaxel; Protein Binding; Pyrones; Solutions; Stereoisomerism; Structure-Activity Relationship; Tubulin	2011
Mariculture and natural production of the antitumoural (+)-discodermolide by the Caribbean marine sponge Discodermia dissoluta. Marine biotechnology (New York, N.Y.), 2013, Volume: 15, Issue:5 Topics: Alkanes; Animals; Antineoplastic Agents; Aquaculture; Carbamates; Colombia; Lactones; Porifera; Pyrones	2013
Synthesis of (+)-discodermolide by catalytic stereoselective borylation reactions. Angewandte Chemie (International ed. in English), 2014, Sep-01, Volume: 53, Issue:36 Topics: Alkanes; Alkylation; Boron; Carbamates; Catalysis; Lactones; Pyrones; Stereoisomerism	2014
A conversation with Susan Band Horwitz. Annual review of pharmacology and toxicology, 2015, Volume: 55 Topics: Alkanes; Antineoplastic Agents, Phytogenic; Biomedical Research; Carbamates; Career Choice; Drug Discovery; History, 20th Century; History, 21st Century; Humans; Lactones; Molecular Targeted Therapy; Paclitaxel; Pharmacology; Pyrones; Tubulin Modulators	2015
Structural Basis of Microtubule Stabilization by Discodermolide. Chembiochem : a European journal of chemical biology, 2017, 05-18, Volume: 18, Issue:10 Topics: Alkanes; Binding Sites; Bridged-Ring Compounds; Carbamates; Crystallography, X-Ray; Humans; Lactones; Microtubules; Pyrones; Taxoids; Tubulin; Tubulin Modulators	2017
Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners. Journal of natural products, 2018, 03-23, Volume: 81, Issue:3 Topics: Alkanes; Antineoplastic Agents; Carbamates; Dose-Response Relationship, Drug; Humans; Lactones; Microtubules; Paclitaxel; Pyrones; Transcription, Genetic; Tubulin; Tumor Cells, Cultured	2018
Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence. Molecular pharmacology, 2020, Volume: 98, Issue:2 Topics: A549 Cells; Alkanes; Area Under Curve; Carbamates; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Lactones; Molecular Structure; Ovarian Neoplasms; Pyrones; Taxoids; Triple Negative Breast Neoplasms; Tubulin Modulators	2020