carbamates and dirlotapide

carbamates has been researched along with dirlotapide in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (66.67)29.6817
2010's4 (26.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Barry, CJ; Bertinato, P; Blize, AE; Bronk, BS; Dirlam, JP; Haven, ML; Hickman, A; Jaynes, BH; Kolosko, NL; Li, J; Manion, TB; Miskell, C; Pillai, UA; Tibbitts, JS1
Gossellin, J; Sunderland, SJ; Wren, JA1
Bessire, AJ; Lynch, MP; Merritt, DA; Sams, JP; Vaz, AD1
King, VL; Lynch, MP; Merritt, DA1
Campbell, SL; Hickman, MA; King, VL; Wren, JA1
Gossellin, J; Hickman, MA; Kerlin, RL; King, VL; Krautmann, MJ; Schmahai, TJ; Wren, JA1
Gossellin, J; Peachey, S; Rowan, TG; Sherington, J; Sunderland, SJ1
Boucher, JF; Kirk, CA; Sunderland, SJ; Wren, JA1
Eagleson, JS; Gossellin, J; McKelvie, J; Rowan, TG; Sherington, J; Sunderland, SJ; Wren, JA1
Campbell, SL; Eagleson, JS; Gossellin, J; King, VL; Ramudo, AA; Sunderland, SJ; Wren, JA1
Bessire, AJ; Sharma, R; Vaz, AD; Walker, GS; Wang, WW1
Bartlett, JA; Bertinato, P; Bessire, AJ; Cosgrove, J; Foley, PM; Manion, TB; Minich, ML; Ramos, B; Reese, MR; Robinson, RP; Schmahai, TJ; Swick, AG; Tess, DA; Vaz, A; Wolford, A1
Bessire, AJ; Sun, H; Vaz, A1
Ables, GP; Birtles, S; Blaner, WS; Buckett, LK; Ginsberg, HN; Goldberg, IJ; Hernandez-Ono, A; Huang, LS; Turnbull, AV; Vogel, S; Yang, KJ; Yu, S; Yuen, JJ1
da Motta, KP; Domingues, NLC; Luchese, C; Santos, BF; Wilhelm, EA1

Reviews

1 review(s) available for carbamates and dirlotapide

ArticleYear
Dirlotapide: a review of its properties and role in the management of obesity in dogs.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Animals; Anti-Obesity Agents; Carbamates; Dog Diseases; Dogs; Indoles; Obesity

2007

Trials

7 trial(s) available for carbamates and dirlotapide

ArticleYear
Pharmacokinetics of dirlotapide in the dog.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Area Under Curve; Carbamates; Cross-Over Studies; Dogs; Female; Indoles; Injections, Intravenous; Male

2007
Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Absorptiometry, Photon; Adipose Tissue; Administration, Oral; Animals; Anti-Obesity Agents; Body Composition; Body Weight; Carbamates; Carrier Proteins; Dog Diseases; Dogs; Eating; Female; Indoles; Male; Obesity; Treatment Outcome

2007
The safety of dirlotapide in dogs.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Carbamates; Dog Diseases; Dogs; Female; Indoles; Male; Obesity; Safety

2007
Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Absorptiometry, Photon; Administration, Oral; Animals; Anti-Obesity Agents; Carbamates; Dog Diseases; Dogs; Eating; Female; Indoles; Male; Pedigree; Treatment Outcome; Weight Loss

2007
Influence of dirlotapide, a microsomal triglyceride transfer protein inhibitor, on the digestibility of a dry expanded diet in adult dogs.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animal Feed; Animals; Anti-Obesity Agents; Carbamates; Carrier Proteins; Diet; Digestion; Dog Diseases; Dogs; Double-Blind Method; Female; Indoles; Male; Obesity; Prospective Studies; Treatment Outcome

2007
An evaluation of dirlotapide to reduce body weight of client-owned dogs in two placebo-controlled clinical studies in Europe.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Body Weight; Carbamates; Dog Diseases; Dogs; Europe; Female; Indoles; Male; Ownership; Pedigree; Treatment Outcome; Weight Loss

2007
Efficacy and safety of dirlotapide in the management of obese dogs evaluated in two placebo-controlled, masked clinical studies in North America.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Carbamates; Dog Diseases; Dogs; Female; Indoles; Male; North America; Obesity; Treatment Outcome

2007

Other Studies

7 other study(ies) available for carbamates and dirlotapide

ArticleYear
In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
    Bioorganic & medicinal chemistry letters, 2007, Apr-01, Volume: 17, Issue:7

    Topics: Animals; Carbamates; Carboxylic Acids; Carrier Proteins; Chemistry, Pharmaceutical; Dogs; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; Obesity; Rats

2007
Absorption, distribution, metabolism, and excretion of dirlotapide in the dog.
    Journal of veterinary pharmacology and therapeutics, 2007, Volume: 30 Suppl 1

    Topics: Administration, Oral; Animals; Anti-Obesity Agents; Bile; Carbamates; Carbon Radioisotopes; Dogs; Female; Indoles; Male; Tissue Distribution

2007
The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites.
    Rapid communications in mass spectrometry : RCM, 2010, Jul-30, Volume: 24, Issue:14

    Topics: Animals; Carbamates; Catalysis; Chromatography, Liquid; Dealkylation; Female; Indoles; Male; Molecular Structure; Oxygen Isotopes; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2010
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Aminoquinolines; Animals; Benzamides; Carbamates; Carrier Proteins; Dogs; Drug Evaluation, Preclinical; Humans; Indoles; Microsomes, Liver; Rats; Triglycerides

2011
Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Carbamates; Catalysis; Catalytic Domain; Chemistry, Pharmaceutical; Computer Simulation; Crystallization; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Drug Design; Indoles; Ligands; Mass Spectrometry; Microsomes, Liver; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Conformation; Temperature

2012
Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.
    Journal of lipid research, 2012, Volume: 53, Issue:11

    Topics: Animals; Carbamates; Carrier Proteins; Chylomicrons; Diacylglycerol O-Acyltransferase; Gastric Emptying; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Male; Mice; Mice, Mutant Strains; Peptide Fragments; Postprandial Period; Receptors, Glucagon; Retinoids; Triglycerides

2012
Target enzymes in oxaliplatin-induced peripheral neuropathy in Swiss mice: A new acetylcholinesterase inhibitor as therapeutic strategy.
    Chemico-biological interactions, 2022, Jan-25, Volume: 352

    Topics: Adenosine Triphosphatases; Analgesics; Animals; Anxiety; Benzoates; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Female; Hippocampus; Indoles; Male; Mice; Oxaliplatin; Oxidative Stress; Peripheral Nervous System Diseases; Spinal Cord; Thiadiazoles; Thiazoles

2022