carbamates and biln 2061

carbamates has been researched along with biln 2061 in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	34 (72.34)	29.6817
2010's	13 (27.66)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anderson, PC; Bailey, M; Beaulieu, P; Bolger, G; Bonneau, P; Bös, M; Cameron, DR; Cartier, M; Cordingley, MG; Faucher, AM; Goudreau, N; Kawai, SH; Kukolj, G; Lagacé, L; Lamarre, D; LaPlante, SR; Llinàs-Brunet, M; Narjes, H; Poupart, MA; Rancourt, J; Sentjens, RE; Simoneau, B; St George, R; Steinmann, G; Thibeault, D; Tsantrizos, YS; Weldon, SM; Yong, CL	1
Rice, CM	1
Brennan, DL; Cottrell, KM; Fulghum, JR; Gates, CA; Hsiao, HM; Kwong, AD; Lin, C; Lin, K; Luong, YP; Ma, S; Maxwell, JP; Perni, RB; Rao, BG; Wei, YY	1
Wei, L	1
Britt, SD; Court, JJ; Courtney, LF; Deininger, DD; Farmer, LJ; Gates, CA; Harbeson, SL; Levin, RB; Lin, C; Lin, K; Luong, YP; Moon, YC; O'Malley, ET; Perni, RB; Pitlik, J; Rao, BG; Thomson, JA; Tung, RD; Van Drie, JH; Wei, Y	1
He, W; Huang, PP; Klein, LL; Lu, L; Mo, H; Molla, A; Pilot-Matias, TJ; Pithawalla, R; Randolph, JT; Stewart, KD	1
Bousquet, C; Gingras, R; Lagacé, L; Lamarre, D; Maurice, R; Thibeault, D; White, PW	1
Bailey, MD; Beaulieu, PL; Brochu, C; Duceppe, JS; Faucher, AM; Ferland, JM; Ghiro, E; Gorys, V; Halmos, T; Kawai, SH; Llinàs-Brunet, M; Poirier, M; Simoneau, B; Tsantrizos, YS	1
Tsantrizos, YS	1
Benhamou, Y; Calleja, JL; Chaves, RL; Crönlein, J; Erhardt, A; Forns, X; Hinrichsen, H; Nehmiz, G; Reiser, M; Sentjens, RE; Steinmann, GG; Wedemeyer, H; Yong, CL	1
Pawlotsky, JM	1
Lemon, SM; Li, K; Yi, M	1
Avendano, C; Benhamou, Y; Hinrichsen, H; Nehmiz, G; Reesink, HW; Reiser, M; Riba, N; Steinmann, GG; Wedemeyer, H; Yong, CL	1
Girish, C	1
Brennan, DL; Frantz, JD; Fulghum, JR; Gates, CA; Kwong, AD; Lin, C; Lin, K; Luong, YP; Ma, S; Perni, RB; Rao, BG; Wei, YY	1
Chang, CF; Hsu, JT; Lee, JC; Lien, TW; Yu, MC	1
Cheng, G; Chisari, FV; Zhong, J	1
Aukerman, L; Collett, M; Douglas, D; Gao, T; Hashash, A; Hsi, B; Kline, J; Kneteman, NM; Kovelsky, R; Mercer, DF; Ni, ZJ; O'Connell, J; Schiller, D; Tyrrell, DL; Weiner, AJ; Zhu, Q	1
Benhamou, Y; Calleja, JL; Forns, X; Herrmann, E; Hinrichsen, H; Manns, MP; Nehmiz, G; Reesink, H; Reiser, M; Sarrazin, C; Steinmann, GG; Zeuzem, S	1
Farina, V; Haddad, N; Tan, J	1
Dekhtyar, T; Han, L; Koev, G; Lin, CT; Mo, H; Molla, A; Ng, TI; Yan, P	1
Brenner, M; Donsbach, K; Farina, V; Feng, X; Frutos, RP; Fuchs, V; Gallou, F; Haddad, N; Houpis, IN; Johnson, M; Kreye, P; Nicola, T; Ridges, MD; Samstag, W; Simpson, RD; Smith-Keenan, LL; Spinelli, EM; Tan, J; Vitous, J; Wang, XJ; Wei, X; Winter, E; Xu, J; Xu, Y; Yee, NK; Zhang, L	1
Aukerman, SL; Garrett, EN; Hollenbach, PW; Mendel, DB; Oei, Y; Patawaran, MB; Weiner, AJ; Zhu, Q	1
Amrani, N; Bouzidi, M; Cacoub, P; Courcambeck, J; Halfon, P; Jouirou, B; Pèpe, G; Perbost, R; Sabatier, JM	1
De Vos, R; Leroux-Roels, G; Libbrecht, L; Meuleman, P; Roskams, T; Vanwolleghem, T	1
Bes, M; Cubero, M; Esteban, JI; Esteban, R; Guardia, J; Otero, T; Quer, J; Sauleda, S	1
Busacca, CA; Farina, V; Han, Z; Hao, MH; Senanayake, CH; Shu, C; Wei, X; Yee, NK; Zeng, X	1
Glenn, JS; Lin, MZ; Tsien, RY	1
Gonzàlez-Candelas, F; López-Labrador, FX; Moya, A	1
Delouvroy, F; Hu, L; Kock, Hd; Lenz, O; Lin, TI; McGowan, D; Nilsson, M; Raboisson, P; Rosenquist, S; Samuelsson, B; Simmen, K; Surleraux, D; Tahri, A; Vendeville, S; Vreken, WV; Wigerinck, P	1
Bush, KJ; Carroll, SS; DiMuzio, J; Liverton, NJ; Lyle, TA; McCauley, JA; McIntyre, CJ; Nguyen, KT; Olsen, DB; Romano, JJ; Ross, CW; Rudd, MT; Stahlhut, MW; Vacca, JP; Varga, SL	1
Allen, TM; Berical, A; Berlin, AM; Bihl, F; Birch, C; Birren, BW; Carlson, J; Cerny, A; Chung, RT; Daar, ES; Donfield, SM; Edlin, BR; Fleckenstein, JF; Galagan, JE; Gomperts, ED; Heckerman, D; Henn, MR; Jacobson, IM; Kim, AY; Kleyman, M; Kodira, C; Koehrsen, M; Kuntzen, T; Lake-Bakaar, GV; Lauer, GM; Ledlie, T; Lee, B; Lennon, N; Liu, Z; Madey, MA; Marion, T; McMahon, CM; Nusbaum, C; Park, VM; Reyor, LL; Roberts, AD; Rosen, HR; Schneidewind, A; Schulze Zur Wiesch, J; Spengler, U; Talal, AH; Timm, J; Walker, BD; Xing, Y; Young, SK	1
Ciaramella, G; Corbau, R; Flores, MV; Strawbridge, J	1
Aya, T; Cai, J; Chen, AP; Cheng, Y; Cheng, YC; Dutschman, GE; Grill, SP; Gullen, EA; Hamilton, AD; Lindenbach, BD; Tsou, LK	1
Marquis, M; Massariol, MJ; Thibeault, D; White, PW; Zhao, S	1
Deshpande, M; Huang, M; Miller, MD; Mo, H; Murray, B; Qi, X; Rhodes, G; Sun, SC; Wang, K; Wang, Y; Yang, C	1
Kim, AY; Kluge, SF; Roggendorf, M; Salloum, S; Timm, J	1
Huang, Q; Knight, BL; Pack, FD; Seidler, RW; Stern, JO; Stoltz, JH	1
Binder, J; Diehl, W; Lingardo, L; Love, R; Maegley, K; Patick, AK; Smith, GJ; Tetangco, S; Weinshank, M	1
Delang, L; Froeyen, M; Neyts, J; Vliegen, I	1
Busacca, CA; Campbell, SJ; Gonnella, NC; Jones, PJ; Saha, AK; Senanayake, CH	1
Beran, RK; Bush, CO; Delaney, WE; Greenstein, AE	1
Anwar, MI; Danielson, UH; Ehrenberg, AE; Gustafsson, SS; Schmuck, B; Stenberg, G	1
Akberdin, IR; Clausznitzer, D; Demenkov, PS; Gursky, VV; Ivanisenko, NV; Ivanisenko, VA; Kaderali, L; Kolchanov, NA; Kozlov, KN; Likhoshvai, VA; Mishchenko, EL; Samsonov, AM; Samsonova, MG; Todorov, DI	1
Hodges, MR; Ottosen, S; Parsley, TB; Patick, AK; Raney, AK; van der Veer, E; van Doorn, LJ; Yang, L; Zeh, K	1
Lee, JM; Park, JH; Yang, CM; Yoon, JC	1

Trials

6 trial(s) available for carbamates and biln 2061

Article	Year
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature, 2003, Nov-13, Volume: 426, Issue:6963 Topics: Administration, Oral; Antiviral Agents; Carbamates; Double-Blind Method; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Male; Polyproteins; Protein Processing, Post-Translational; Quinolines; Serine Proteinase Inhibitors; Thiazoles; Viral Load; Viral Nonstructural Proteins; Viral Proteins	2003
Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology, 2004, Volume: 127, Issue:5 Topics: Antiviral Agents; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hepatitis C, Chronic; Humans; Macrocyclic Compounds; Male; Middle Aged; Protease Inhibitors; Quinolines; RNA, Viral; Serine Endopeptidases; Thiazoles; Viral Load	2004
"Strong reasons make strong actions"--The antiviral efficacy of NS3/4A protease inhibitors. Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:3 Topics: Antiviral Agents; Carbamates; Double-Blind Method; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Macrocyclic Compounds; Quinolines; RNA, Viral; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2005
Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:4 Topics: Administration, Oral; Adult; Carbamates; Double-Blind Method; Drug Administration Schedule; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Kinetics; Macrocyclic Compounds; Male; Middle Aged; Pilot Projects; Prospective Studies; Quinolines; Serine Proteinase Inhibitors; Thiazoles; Viral Load; Viral Nonstructural Proteins	2005
Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061. Antiviral therapy, 2006, Volume: 11, Issue:3 Topics: Adult; Antiviral Agents; Area Under Curve; Carbamates; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Kinetics; Macrocyclic Compounds; Male; Middle Aged; Models, Biological; Quinolines; RNA, Viral; Serine Proteinase Inhibitors; Thiazoles	2006
In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: 5' Untranslated Regions; Antiviral Agents; Carbamates; Cyclohexanols; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Macrocyclic Compounds; MicroRNAs; Molecular Targeted Therapy; Mutation; Oligonucleotides; Oligopeptides; Pyrrolidines; Quinolines; Replicon; Thiazoles; Thiophenes; Valine	2015

Other Studies

41 other study(ies) available for carbamates and biln 2061

Article	Year
Virology: fresh assault on hepatitis C. Nature, 2003, Nov-13, Volume: 426, Issue:6963 Topics: Antiviral Agents; Carbamates; Clinical Trials as Topic; Drug Design; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Quinolines; Serine Proteinase Inhibitors; Thiazoles; Viral Load; Viral Nonstructural Proteins	2003
In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms. The Journal of biological chemistry, 2004, Apr-23, Volume: 279, Issue:17 Topics: Amino Acids; Aspartic Acid; Binding Sites; Carbamates; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Genes, Dominant; Hepacivirus; Inhibitory Concentration 50; Kinetics; Macrocyclic Compounds; Models, Chemical; Models, Molecular; Mutation; Oligopeptides; Plasmids; Protein Structure, Tertiary; Quinolines; Serine Proteinase Inhibitors; Thiazoles; Time Factors; Viral Nonstructural Proteins	2004
[Review of recent research on hepatitis C therapy for 54th annual meeting of the American association for the study of liver diseases]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2004, Volume: 12, Issue:2 Topics: Carbamates; Hepatitis C; Humans; Interferon-alpha; Interferons; Macrocyclic Compounds; Oligonucleotides, Antisense; Quinolines; RNA-Dependent RNA Polymerase; Serum Albumin; Serum Albumin, Human; Thiazoles; Viral Hepatitis Vaccines	2004
Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization. Bioorganic & medicinal chemistry letters, 2004, Mar-22, Volume: 14, Issue:6 Topics: Carbamates; Hepacivirus; Macrocyclic Compounds; Quinolines; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins	2004
Hepatitis C drug being developed. AIDS patient care and STDs, 2004, Volume: 18, Issue:1 Topics: Carbamates; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Quinolines; Thiazoles; Treatment Outcome; Viral Load	2004
Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:6 Topics: Amino Acid Sequence; Amino Acid Substitution; Carbamates; Cloning, Molecular; Drug Resistance, Viral; Genotype; Hepacivirus; Macrocyclic Compounds; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenotype; Quinolines; Replicon; RNA, Viral; Serine Proteinase Inhibitors; Thiazoles; Transcription, Genetic; Transfection; Viral Plaque Assay	2004
Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061. Journal of virology, 2004, Volume: 78, Issue:14 Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Carbamates; Escherichia coli; Genotype; Hepacivirus; Humans; Kinetics; Macrocyclic Compounds; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Mutation; Quinolines; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2004
Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans. Organic letters, 2004, Aug-19, Volume: 6, Issue:17 Topics: Antiviral Agents; Carbamates; Hepacivirus; Humans; Macrocyclic Compounds; Molecular Structure; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins	2004
The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061--from the NMR tube to the clinic. Biopolymers, 2004, Volume: 76, Issue:4 Topics: Carbamates; Drug Design; Hepacivirus; Hepatitis C; Humans; In Vitro Techniques; Macrocyclic Compounds; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Quinolines; Serine Proteinase Inhibitors; Static Electricity; Thiazoles; Viral Nonstructural Proteins	2004
Hepatitis C: it's a long way to new therapy, it's a long way to go... Gastroenterology, 2004, Volume: 127, Issue:5 Topics: Antiviral Agents; Carbamates; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Quinolines; Thiazoles	2004
Use of placebo: is it a boon or bane? Gastroenterology, 2005, Volume: 128, Issue:3 Topics: Antiviral Agents; Carbamates; Clinical Trials as Topic; Ethics, Clinical; Hepacivirus; Hepatitis C, Chronic; Humans; Macrocyclic Compounds; Placebos; Protease Inhibitors; Quinolines; Serine Endopeptidases; Thiazoles	2005
In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061. The Journal of biological chemistry, 2005, Nov-04, Volume: 280, Issue:44 Topics: Amino Acid Substitution; Amino Acids; Aspartic Acid; Binding Sites; Carbamates; Drug Resistance, Viral; Genes, Dominant; Hepacivirus; Humans; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Macrocyclic Compounds; Models, Chemical; Models, Molecular; Mutation; Oligopeptides; Quinolines; Replicon; RNA, Viral; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2005
High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors. Assay and drug development technologies, 2005, Volume: 3, Issue:4 Topics: Alkaline Phosphatase; Antiviral Agents; Carbamates; Carrier Proteins; Cell Line; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, Reporter; Green Fluorescent Proteins; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Plasmids; Quinolines; Recombinant Fusion Proteins; Scintillation Counting; Serine Proteinase Inhibitors; Thiazoles; Transfection; Viral Nonstructural Proteins; Viral Proteins	2005
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 2006, May-30, Volume: 103, Issue:22 Topics: Active Transport, Cell Nucleus; Carbamates; Cell Line, Tumor; Gene Expression Regulation, Viral; Hepacivirus; Humans; I-kappa B Kinase; Interferon Regulatory Factor-3; Interferon-beta; Interferon-Stimulated Gene Factor 3; Macrocyclic Compounds; Promoter Regions, Genetic; Protease Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinolines; Response Elements; RNA, Double-Stranded; Signal Transduction; Thiazoles; Viral Nonstructural Proteins	2006
Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:6 Topics: Analysis of Variance; Animals; Antiviral Agents; Base Sequence; Carbamates; Disease Models, Animal; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Interferon alpha-2; Interferon-alpha; Macrocyclic Compounds; Mice; Mice, SCID; Molecular Sequence Data; Oncogene Proteins, Fusion; Probability; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Thiazoles; Treatment Outcome	2006
Convergent synthesis of the quinolone substructure of BILN 2061 via carbonylative Sonogashira coupling/cyclization. The Journal of organic chemistry, 2006, Jun-23, Volume: 71, Issue:13 Topics: Alkynes; Carbamates; Catalysis; Cyclization; Hydrocarbons, Iodinated; Macrocyclic Compounds; Molecular Structure; Palladium; Quinolines; Quinolones; Stereoisomerism; Thiazoles	2006
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro. Antiviral research, 2007, Volume: 73, Issue:1 Topics: Antiviral Agents; Carbamates; Cell Line; Drug Synergism; Enzyme Inhibitors; Hepacivirus; Humans; Inhibitory Concentration 50; Interferon-alpha; Macrocyclic Compounds; Microbial Sensitivity Tests; Quinolines; RNA-Dependent RNA Polymerase; Serine Proteinase Inhibitors; Thiazoles	2007
Efficient large-scale synthesis of BILN 2061, a potent HCV protease inhibitor, by a convergent approach based on ring-closing metathesis. The Journal of organic chemistry, 2006, Sep-15, Volume: 71, Issue:19 Topics: Antiviral Agents; Carbamates; Chromatography, High Pressure Liquid; Cyclization; Hepacivirus; Macrocyclic Compounds; Molecular Structure; Protease Inhibitors; Quinolines; Thiazoles	2006
Novel robust hepatitis C virus mouse efficacy model. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10 Topics: Animals; Antiviral Agents; Carbamates; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Macrocyclic Compounds; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Quinolines; Thiazoles; Virus Replication	2006
Resistance of hepatitis C virus to NS3-4A protease inhibitors: mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations. Antiviral therapy, 2006, Volume: 11, Issue:7 Topics: Binding Sites; Carbamates; Drug Resistance, Viral; Hepacivirus; Macrocyclic Compounds; Models, Molecular; Point Mutation; Quinolines; Serine Endopeptidases; Thiazoles; Viral Nonstructural Proteins	2006
Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse. Gastroenterology, 2007, Volume: 133, Issue:4 Topics: Administration, Oral; Animals; Antiviral Agents; Carbamates; Drug Evaluation, Preclinical; Heart Diseases; Hepacivirus; Hepatitis C; Humans; Liver; Liver Transplantation; Macrocyclic Compounds; Mice; Mice, SCID; Mice, Transgenic; Mitochondria, Heart; Mitochondrial Swelling; Models, Animal; Myocytes, Cardiac; Protease Inhibitors; Quinolines; Thiazoles; Time Factors; Transplantation, Heterologous; Urokinase-Type Plasminogen Activator; Viral Load; Viral Nonstructural Proteins	2007
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient. Virology, 2008, Jan-20, Volume: 370, Issue:2 Topics: Adult; Amino Acid Sequence; Base Sequence; Carbamates; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Macrocyclic Compounds; Male; Molecular Sequence Data; Oligopeptides; Point Mutation; Proline; Quinolines; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2008
RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061. Organic letters, 2008, Mar-20, Volume: 10, Issue:6 Topics: Carbamates; Cyclization; Hepacivirus; Macrocyclic Compounds; Protease Inhibitors; Quinolines; Thiazoles	2008
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jun-03, Volume: 105, Issue:22 Topics: Animals; Carbamates; Cell Line; Drosophila melanogaster; Epitopes; Humans; Macrocyclic Compounds; Methods; Neurons; Protease Inhibitors; Protein Biosynthesis; Quinolines; Rats; Recombinant Fusion Proteins; Synapses; Thiazoles; Viral Nonstructural Proteins	2008
Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates. Antiviral therapy, 2008, Volume: 13, Issue:4 Topics: Amino Acid Sequence; Antiviral Agents; Carbamates; Carrier Proteins; Drug Resistance, Viral; Global Health; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Microbial Sensitivity Tests; Molecular Sequence Data; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Sequence Alignment; Thiazoles; Viral Nonstructural Proteins; Viral Proteins	2008
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors. Bioorganic & medicinal chemistry letters, 2008, Sep-15, Volume: 18, Issue:18 Topics: Administration, Oral; Animals; Antiviral Agents; Carbamates; Combinatorial Chemistry Techniques; Dogs; Liver; Macrocyclic Compounds; Molecular Structure; Quinolines; Rats; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2008
Bismacrocyclic inhibitors of hepatitis C NS3/4a protease. Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:47 Topics: Antiviral Agents; Carbamates; Carrier Proteins; Hepacivirus; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Protease Inhibitors; Quinolines; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins; Viral Proteins	2008
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:6 Topics: Antiviral Agents; Carbamates; Cohort Studies; Drug Resistance, Viral; Female; Genetic Testing; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Male; Mutation; Oligopeptides; Phenylthiourea; Phylogeny; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load; Viral Nonstructural Proteins	2008
HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism. Biochimica et biophysica acta, 2009, Volume: 1794, Issue:10 Topics: Amino Acid Substitution; Antiviral Agents; Carbamates; Drug Resistance, Viral; Genotype; Half-Life; Hepacivirus; Humans; Kinetics; Macrocyclic Compounds; Models, Biological; Mutation; Oligopeptides; Proline; Quinolines; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2009
A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Antiviral Agents; Carbamates; Cell Line; DNA, Mitochondrial; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Viral; Drug Synergism; Genotype; Hepacivirus; Humans; Interferon alpha-2; Interferon-alpha; Macrocyclic Compounds; Mesoporphyrins; Quinolines; Recombinant Proteins; Replicon; RNA, Viral; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins	2010
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins. Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1 Topics: Amino Acid Sequence; Antiviral Agents; Carbamates; Carrier Proteins; Cloning, Molecular; DNA; Genotype; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Molecular Sequence Data; Protease Inhibitors; Quinolines; RNA; RNA Helicases; Thiazoles; Viral Nonstructural Proteins; Viral Proteins	2010
Estimation of inhibitory quotient using a comparative equilibrium dialysis assay for prediction of viral response to hepatitis C virus inhibitors. Journal of viral hepatitis, 2011, Volume: 18, Issue:5 Topics: Antiviral Agents; Blood Proteins; Carbamates; Cell Line; Comparative Effectiveness Research; Dialysis; Hepacivirus; Hepatitis C; Humans; Inhibitory Concentration 50; Macrocyclic Compounds; Membranes, Artificial; Oligopeptides; Phenylthiourea; Plasma; Proline; Protease Inhibitors; Protein Binding; Quinolines; RNA, Viral; Thiazoles; Viral Load	2011
The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also leads the virus to escape from HLA-A68-restricted CD8 T cells. Antiviral research, 2010, Volume: 87, Issue:2* Topics: Amino Acid Substitution; Antiviral Agents; Carbamates; Carrier Proteins; CD8-Positive T-Lymphocytes; Drug Resistance, Viral; Epitopes, T-Lymphocyte; Hepacivirus; HLA-A Antigens; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Mutation, Missense; Quinolines; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication	2010
A twenty-eight-day mechanistic time course study in the rhesus monkey with hepatitis C virus protease inhibitor BILN 2061. Toxicologic pathology, 2011, Volume: 39, Issue:3 Topics: Administration, Oral; Animals; Antiviral Agents; Biomarkers; Carbamates; Cardiotoxins; Drug Evaluation, Preclinical; Female; Hepacivirus; Macaca mulatta; Macrocyclic Compounds; Male; Mitochondrial Swelling; Myocytes, Cardiac; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins	2011
Development of hepatitis C virus chimeric replicons for identifying broad spectrum NS3 protease inhibitors. Antiviral research, 2011, Volume: 91, Issue:2 Topics: Animals; Antiviral Agents; Base Sequence; Binding Sites; Carbamates; Cell Line; Cloning, Molecular; Fluorescence Resonance Energy Transfer; Genetic Variation; Genetic Vectors; Genotype; Hepacivirus; Humans; Macrocyclic Compounds; Microbial Sensitivity Tests; Oligopeptides; Phylogeny; Protease Inhibitors; Quinolines; Replicon; Sequence Analysis, Protein; Thiazoles; Viral Nonstructural Proteins; Virus Replication	2011
Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9 Topics: Antiviral Agents; Carbamates; Cell Line; Drug Resistance, Viral; Hepacivirus; Humans; Macrocyclic Compounds; Mutagenesis, Site-Directed; Mutation; Oligopeptides; Phenotype; Quinolines; Replicon; Thiazoles; Transfection; Virus Replication	2011
Probing the cation binding modes of macrocyclic HCV protease inhibitor BILN 2061 by multinuclear NMR. Journal of pharmaceutical and biomedical analysis, 2012, Volume: 70 Topics: Antiviral Agents; Binding Sites; Carbamates; Cations; Macrocyclic Compounds; Magnetic Resonance Spectroscopy; Metals, Alkali; Metals, Alkaline Earth; Molecular Structure; Protease Inhibitors; Quinolines; Thiazoles; Transition Elements; Viral Nonstructural Proteins	2012
Hepatitis C viral entry inhibitors prolong viral suppression by replication inhibitors in persistently-infected Huh7 cultures. PloS one, 2013, Volume: 8, Issue:6 Topics: Antiviral Agents; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Synergism; Hepacivirus; Hepatocytes; Humans; Imidazoles; Macrocyclic Compounds; Pyrrolidines; Quinolines; Thiazoles; Time Factors; Valine; Viral Load; Virus Internalization; Virus Replication	2013
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2014, Volume: 29, Issue:6 Topics: Antiviral Agents; Carbamates; Cloning, Molecular; Cyclopropanes; Drug Resistance, Viral; Escherichia coli; Gene Expression; Genetic Variation; Genotype; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Macrocyclic Compounds; Mutation; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Quinolines; Recombinant Proteins; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2014
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants. PloS one, 2014, Volume: 9, Issue:3 Topics: Antiviral Agents; Carbamates; Drug Resistance, Viral; Hepacivirus; Macrocyclic Compounds; Models, Statistical; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Quinolines; Replicon; RNA, Viral; Stochastic Processes; Thiazoles; Viral Nonstructural Proteins; Virus Replication	2014
Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3. PloS one, 2017, Volume: 12, Issue:4 Topics: Carbamates; Cell Line; Cell Survival; Coculture Techniques; Down-Regulation; Hepacivirus; Hepatitis C; Humans; Interferon-gamma; Interleukin-12; K562 Cells; Killer Cells, Natural; Macrocyclic Compounds; Microscopy, Confocal; Natural Cytotoxicity Triggering Receptor 1; Natural Cytotoxicity Triggering Receptor 3; Quinolines; Recombinant Proteins; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins	2017