carbamates has been researched along with anandamide in 151 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.66) | 18.2507 |
| 2000's | 46 (30.46) | 29.6817 |
| 2010's | 94 (62.25) | 24.3611 |
| 2020's | 10 (6.62) | 2.80 |
| Authors | Studies |
|---|---|
| Abood, ME; Aung, MM; Martin, BR; Ng, EW; Razdan, RK | 1 |
| Duranti, A; Kathuria, S; Mor, M; Park, C; Piersanti, G; Piomelli, D; Plazzi, PV; Rivara, S; Tarzia, G; Tontini, A | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| Duranti, A; Fegley, D; Gaetani, S; Mor, M; Piomelli, D; Tarzia, G; Tontini, A | 1 |
| Lambert, DM; Okamoto, Y; Sun, YX; Tsuboi, K; Ueda, N; Zhao, LY | 1 |
| Fegley, D; Gutierrez, T; Hohmann, AG; Piomelli, D; Suplita, RL | 1 |
| Bambico, FR; Bortolato, M; Campolongo, P; Cassano, T; Cuomo, V; Debonnel, G; Duranti, A; Gobbi, G; Goldberg, SR; Mangieri, R; Mor, M; Morgese, MG; Piomelli, D; Solinas, M; Tarzia, G; Tontini, A; Trezza, V | 1 |
| Jones, PG; Ramarao, MK; Rogers, KE; Uveges, A; Wang, Y; Xu, J | 1 |
| Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M | 1 |
| Goldberg, SR; Justinova, Z; Solinas, M; Tanda, G | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Cross-Mellor, SK; Ossenkopp, KP; Parker, LA; Piomelli, D | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Piomelli, D; Solinas, M; Tanda, G; Vadivel, SK; Wertheim, CE; Yasar, S | 1 |
| Ali, N; Chapman, V; Chimenti, M; de Lago, E; Fernandez-Ruiz, J; Kendall, DA; Millns, PJ; Ryland, E | 1 |
| Ho, WS; Randall, MD | 1 |
| Lam, FF; Luk, PW; Ng, ES | 1 |
| Ahn, K; Cravatt, BF; Lichtman, AH; Martin, BR; Naidu, PS; Varvel, SA | 1 |
| Alajakku, K; Fowler, CJ; Thors, L | 1 |
| Drysdale, AJ; Pertwee, RG; Platt, B; Ryan, D | 1 |
| Agrò, AF; Bagetta, G; Bari, M; Cerulli, A; Corasaniti, MT; De Simone, C; Gasperi, V; Maccarrone, M; Morrone, LA; Nucci, C; Tartaglione, R; Terrinoni, A | 1 |
| Eriksson, J; Fowler, CJ; Thors, L | 1 |
| Gorzalka, BB; Hill, MN; Morrish, AC | 1 |
| Herradón, E; López-Miranda, V; Martín, MI | 1 |
| Kaiser, N; Lutz, B; Monory, K; Moreira, FA | 1 |
| Cassano, T; Cuomo, V; Giuffrida, A; Morgese, MG | 1 |
| Fratta, W; Goldberg, SR; Haller, J; Makriyannis, A; Medalie, J; Mikics, E; Piomelli, D; Scherma, M; Tanda, G; Vadivel, SK; Yasar, S | 1 |
| Castiglioni, C; Di Marzo, V; Guidali, C; Maccarrone, M; Marras, E; Parolaro, D; Perletti, G; Petrosino, S; Realini, N; Rubino, T; Viganó, D | 1 |
| Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF | 1 |
| Béquet, F; Desbazeille, M; Le Fur, G; Ludwiczak, P; Maftouh, M; Picard, C; Scatton, B; Uzabiaga, F | 1 |
| Bilbao, A; Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Defonseca, FR; Duranti, A; Piomelli, D; Tontini, A | 1 |
| Njie, YF; Qiao, Z; Song, ZH; Wang, W; Xiao, Z | 1 |
| Fowler, CJ; Ghafouri, N | 1 |
| Aguiar, DC; Guimarães, FS; Lisboa, SF; Resstel, LB | 1 |
| Barnes, C; Fadda, P; Fattore, L; Fratta, W; Gamaleddin, I; Goldberg, SR; Haller, J; Justinová, Z; Le Foll, B; Medalie, J; Mikics, E; Panlilio, LV; Piomelli, D; Scherma, M; Stroik, J; Tanda, G; Yasar, S | 1 |
| Haller, VL; Stevens, DL; Welch, SP | 1 |
| Bortolato, M; Chefer, SI; Clapper, JR; Goldberg, SR; Justinova, Z; King, AR; Mangieri, RA; Mukhin, AG; Piomelli, D; Redhi, GH; Yasar, S | 1 |
| Butler, RK; Finn, DP; Gavin, AM; Lang, Y; Rea, K | 1 |
| Billi, S; Farina, M; Franchi, AM; Gervasi, MG; Perez Martinez, S; Rapanelli, M; Ribeiro, ML | 1 |
| Adriani, W; Laviola, G; Marco, EM; Parolaro, D; Rubino, T; Viveros, MP | 1 |
| Gardiner, SM; Ho, WS | 1 |
| Kwiatkowska, M; Limebeer, CL; Litt, DL; Parker, LA; Piomelli, D; Rock, EM | 1 |
| Benton, VM; Bradshaw, HB; Cravatt, BF; Hu, SS; Masuda, K; O'Dell, DK; Rimmerman, N; Stuart, JM; Walker, JM | 1 |
| Abdullah, RA; Boger, DL; Cravatt, BF; Kinsey, SG; Lichtman, AH; Long, JZ; O'Neal, ST; Poklis, JL | 1 |
| Gontinou, C; Karaliota, S; Mavri-Vavayanni, M; Psarra, K; Siafaka-Kapadai, A | 1 |
| Floresco, SB; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Morrish, AC; Viau, V | 1 |
| Fowler, CJ; Thors, L | 1 |
| Booker, L; Burston, JJ; Cravatt, BF; Jin, X; Lichtman, AH; Long, JZ; Nomura, DK; Sim-Selley, LJ; Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Galadari, S; Jaligam, V; Oz, M; Petroianu, G; Shippenberg, TS; Shuba, YM | 1 |
| Burdet, B; De Laurentiis, A; Fernandez-Solari, J; Mohn, C; Rettori, V; Zorrilla Zubilete, MA | 1 |
| Bernardi, G; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Mataluni, G; Musella, A; Rossi, S | 1 |
| Baufreton, J; Manuel, I; Morera-Herreras, T; Rodriguez-Puertas, R; Ruiz-Ortega, JA; Taupignon, A; Ugedo, L | 1 |
| Alger, BE; Kim, J | 1 |
| Bingham, B; Gorzalka, BB; Gray, JM; Hill, MN; Hillard, CJ; Lee, TT; McLaughlin, RJ; Shrestha, L; Viau, V | 1 |
| Alter, BJ; Burston, JJ; Cravatt, BF; Fowler, CJ; Gereau, RW; McKinney, MK; Pertwee, RG; Ross, RA; Thors, L; Wiley, JL | 1 |
| Casarotto, PC; Gomes, FV; Guimarães, FS; Resstel, LB | 1 |
| McMahon, LR; Stewart, JL | 1 |
| Jain, NS; Manna, SS; Umathe, SN | 2 |
| Beltrame, JS; Burdet, J; Cella, M; Franchi, AM; Pardo, R; Ribeiro, ML; Sordelli, MS; Zotta, E | 1 |
| Busquets-Garcia, A; de la Torre, R; Maldonado, R; Ozaita, A; Pastor, A; Puighermanal, E | 1 |
| Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M | 1 |
| Astarita, G; Caprioli, G; Ciccocioppo, R; Cippitelli, A; Duranti, A; Kallupi, M; Piomelli, D; Rodrìguez de Fonseca, F; Sagratini, G; Stopponi, S; Ubaldi, M | 1 |
| Boczán, J; Czikora, Á; Daragó, A; Édes, I; Lizanecz, E; Papp, Z; Tóth, A | 1 |
| Bambico, FR; Gobbi, G; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Stuhr, KL | 1 |
| Bouzin, C; Feron, O; Gallez, B; Hamtiaux, L; Lambert, DM; Masquelier, J; Muccioli, GG | 1 |
| Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD | 1 |
| Buczynski, MW; Chang, JW; Cognetta, AB; Cravatt, BF; Lum, KM; Matthews, ML; Niessen, S; Niphakis, MJ; Parsons, LH; Wang, C | 1 |
| Harding-Rose, C; Khasabov, S; Khasabova, IA; Paz, J; Seybold, VS; Simone, DA | 1 |
| Alexander, SP; Barrett, DA; Bennett, AJ; Burston, J; Chapman, V; Kendall, DA; Norris, LM; Okine, BN; Patel, A; Woodhams, S | 1 |
| Cooper, TB; Hungund, BL; Psychoyos, D; Tejani-Butt, SM; Vinod, KY; Xie, S | 1 |
| Baranowska-Kuczko, M; Kozłowska, H; MacLean, MR; Malinowska, B | 1 |
| Bowie, AG; Campbell, VA; Gowran, A; Keating, SE; Noonan, J; Tanveer, R | 1 |
| Bacigaluppi, M; Bari, M; Brambilla, E; Butti, E; Cambiaghi, M; Cebrian Silla, A; Centonze, D; Comi, G; D'Adamo, P; De Ceglia, R; De Chiara, V; Garcia-Verdugo, JM; Leocani, L; Maccarrone, M; Martino, G; Musella, A; Muzio, L; Quattrini, A; Rossi, S; Teneud, L | 1 |
| Barker, E; Chester, JA; Cooper, BR; Davisson, VJ; Han, B; Kirchhoff, AM; Wright, R | 1 |
| Przewlocka, B; Starowicz, K | 1 |
| Bradshaw, HB; Guindon, J; Hohmann, AG; Lai, Y; Takacs, SM | 1 |
| Burger, F; Cravatt, B; Galan, K; Lenglet, S; Montecucco, F; Pelli, G; Soehnlein, O; Staub, C; Steffens, S; Thomas, A | 1 |
| Avraham, HK; Li, H; Makriyannis, A; Seng, S; Vadivel, SK; Whitten, KM; Wood, JT | 1 |
| Giuffrida, A; Martinez, AA; Seillier, A | 1 |
| Cristino, L; De Petrocellis, L; Di Marzo, V; Korostynski, M; Makuch, W; Malek, N; Petrosino, S; Przewlocka, B; Slezak, M; Starowicz, K; Zychowska, M | 1 |
| Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA | 1 |
| Aliczki, M; Goldberg, SR; Haller, J; Panlilio, LV; Pelczer, KG | 1 |
| Antunes-Rodrigues, J; Elias, LL; Ruginsk, SG; Uchoa, ET | 1 |
| Boccella, S; Comelli, F; Costa, B; De Chiaro, M; Di Marzo, V; Guida, F; Maione, S; Morera, E; Ortar, G; Piscitelli, F; Verde, R | 1 |
| Centonze, D; Laricchiuta, D; Petrosini, L | 1 |
| Aliczki, M; Balogh, Z; Haller, J; Kantor, S; Pelczer, KG; Spitzer, K | 1 |
| Abdullah, RA; Imhof, E; Lichtman, AH; Limebeer, CL; Parker, LA; Rock, EM; Wang, K | 1 |
| Bindila, L; Fleischmann, BK; Lerner, R; Lutz, B; Matthey, M; Wenzel, D; Zimmer, A | 1 |
| Cinar, R; Godlewski, G; Jourdan, T; Kunos, G; Lin, Y; Liu, J; Ntambi, JM; Xiong, K | 1 |
| Becker, A; Hoyer, FF; Kebschull, M; Khoury, M; Lerner, R; Lütjohann, D; Lutz, B; Nickenig, G; Schott, H; Slomka, H; Wojtalla, A; Zimmer, A | 1 |
| Abdullah, RA; Kwilasz, AJ; Lichtman, AH; Negus, SS; Poklis, JL | 1 |
| Basavarajappa, BS; Nagre, NN; Subbanna, S; Xie, S | 1 |
| Bystrowska, B; Filip, M; Gawliński, D; Pomierny, B; Smaga, I; Stankowicz, P | 1 |
| Al Kury, LT; Ali, RM; Galadari, S; Howarth, FC; Oz, M; Rajesh, M; Shuba, YM; Thayyullathil, FT; Yang, KH | 1 |
| Chavant, F; Duranti, A; Francheteau, M; Gennequin, B; Maccarrone, M; Makriyannis, A; Nader, J; Rapino, C; Solinas, M; Thiriet, N | 1 |
| Cravatt, BF; Germano, P; Hama, AT; Milne, GT; Pearson, JP; Sagen, J; Varghese, MS | 1 |
| Bader, M; Brosnihan, KB; Dechend, R; Howlett, AC; McGee, CM; Pulgar, VM; Varagic, J; Yamaleyeva, LM | 1 |
| Drew, GM; Lau, BK; Mitchell, VA; Vaughan, CW | 1 |
| Impastato, RA; Katz, PS; Molina, PE; Rogers, EK; Sulzer, JK; Teng, SX | 1 |
| Abels, C; Chicca, A; Gertsch, J; Nicolussi, S; Rau, M; Rihs, S; Soeberdt, M | 1 |
| Aguiar, DC; Hott, SC; Moreira, FA; Resstel, LB; Viana, TG | 1 |
| de Ceballos, ML; Giusto, NM; Martín-Moreno, AM; Pascual, AC; Pasquaré, SJ | 1 |
| Atsak, P; Campolongo, P; Cuomo, V; Hauer, D; McGaugh, JL; Morena, M; Peloso, A; Ratano, P; Roozendaal, B; Schelling, G; Trabace, L; Trezza, V | 1 |
| Khasabova, IA; Simone, DA; Uhelski, ML | 1 |
| Chauvet, C; Duranti, A; Lardeux, MV; Nicolas, C; Solinas, M; Thiriet, N | 1 |
| Bedse, G; Bellomo, A; Cassano, T; Cifani, C; Duranti, A; Gaetani, S; Lavecchia, MA; Micioni Di Bonaventura, MV; Pace, L; Romano, A; Tempesta, B | 1 |
| Bastos, JR; Batista, LA; Moreira, FA | 1 |
| Camargo, LH; Cunha, FQ; Gomes, FV; Guimarães, FS; Joca, SR; Lisboa, SF; Resstel, LB; Silva, AL; Uliana, DL | 1 |
| Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K | 1 |
| Markert, A; Nozaki, C; Zimmer, A | 1 |
| Campolongo, P; Cuomo, V; Hill, MN; Manduca, A; Morena, M; Palmery, M; Servadio, M; Trabace, L; Trezza, V; Vanderschuren, LJ | 1 |
| Krych, L; Moulton, K; Qin, M; Smith, CB; Xia, Z; Zeidler, Z | 1 |
| Hinz, B; Ivanov, I; Peters, K; Ramer, R; Salamon, A; Wollank, Y | 1 |
| Kregiel, J; Malek, N; Popik, P; Rygula, R; Starowicz, K | 1 |
| Congiu, C; Deplano, A; Fowler, CJ; Fredriksson Sundbom, M; Gouveia-Figueira, S; Hashemian, S; Karlsson, J; Onnis, V; Svensson, M | 1 |
| Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D | 1 |
| Aguilar, DD; Giuffrida, A; Lodge, DJ | 1 |
| Gray, JM; Hill, MN; McLaughlin, RJ; Verlezza, S; Walker, CD | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
| Aliczki, M; Baranyi, M; Barna, I; Goldberg, SR; Haller, J; Sperlagh, B; Till, I | 1 |
| Alapafuja, SO; Bergman, J; Kangas, BD; Leonard, MZ; Makriyannis, A; Nikas, SP; Shukla, VG | 1 |
| Forget, B; Gamaleddin, I; Goldberg, SR; Guranda, M; Le Foll, B | 1 |
| Aymerich, MS; Celorrio, M; Echeverry-Alzate, V; Fernández-Suárez, D; Franco, R; Hillard, CJ; López-Moreno, JA; Maldonado, R; Oyarzábal, J; Ramírez, MJ; Rojo-Bustamante, E | 1 |
| Campolongo, P; Gray, JM; Hill, MN; Leitl, KD; Morena, M; Vecchiarelli, HA | 1 |
| Abdullah, RA; Cabrera, R; Cravatt, BF; Ghosh, S; Lichtman, AH; Maldonado, RL; Mustafa, M; Niphakis, MJ; Wilkerson, JL | 1 |
| Barrett, DA; Couch, DG; Karwad, MA; Larvin, M; Lund, JN; O'Sullivan, SE; Sarmad, S; Theophilidou, E; Wright, KL | 1 |
| Gupta, K; Simone, DA; Uhelski, ML | 1 |
| Finn, DP; Flannery, LE; Henry, RJ; Kerr, DM; Roche, M | 1 |
| Genewsky, A; Heinz, DE; Wotjak, CT | 1 |
| Abouabdellah, A; Bergis, OE; Cohen, C; Dargazanli, G; Fauchey, V; Griebel, G; Lopez-Grancha, M; Pichat, P; Slowinski, F; Stemmelin, J | 1 |
| Akirav, I; Fidelman, S; Hillard, CJ; Lange, R; Mizrachi Zer-Aviv, T | 1 |
| Gong, DY; Hai, KR; Jiang, HX; Ke, BW; Liu, J; Ma, G; Yang, Z; Zhou, C | 1 |
| Cuccurazzu, B; Grilli, M; Nazzaro, C; Parolaro, D; Prini, P; Rubino, T; Tonini, R; Trusel, M; Zamberletti, E | 1 |
| Cavin, JB; Cravatt, BF; Hill, MN; Keenan, CM; Lau, DJ; Makriyannis, A; Morena, M; Sharkey, KA; Sticht, MA; Vemuri, VK | 1 |
| Blanco, E; Fernández-Arjona, MDM; Grondona, JM; López-Ávalos, MD; Pavón, FJ; Rivera, P; Rodríguez de Fonseca, F; Serrano, A; Silva-Peña, D; Suárez, J; Vargas, A | 1 |
| Biernacki, M; Jastrząb, A; Malinowska, B; Remiszewski, P; Skrzydlewska, E; Timoszuk, M; Toczek, M | 1 |
| Aliczki, M; Balogh, Z; Biro, L; Haller, J; Szente, L; Varga, ZK | 1 |
| Aguilera-Portillo, G; Colonnello, A; Galván-Arzate, S; Kotlar, I; Pedraza-Chaverri, J; Rangel-López, E; Santamaría, A; Serratos, IN; Túnez, I; Wajner, M | 1 |
| Correa, FM; Fassini, A; Guimarães, FS; Hartmann, A; Lisboa, SF; Resstel, LB; Scopinho, A | 1 |
| Campolongo, P; Colucci, P; Hill, MN; Mancini, GF; Morena, M; Palmery, M; Puglisi-Allegra, S; Santori, A; Trezza, V | 1 |
| Chen, PS; Chu, MC; Lee, CW; Lin, HC; Lu, TY; Wu, HF | 1 |
| Akirav, I; Maymon, N; Mizrachi Zer-Aviv, T; Sabban, EL | 1 |
| Carnevali, L; Ferlenghi, F; Mor, M; Rivara, S; Sgoifo, A; Spadoni, G; Statello, R; Vacondio, F | 1 |
| Angelucci, CB; Ballone, A; Dainese, E; De Fabritiis, G; Dufrusine, B; Fezza, F; Maccarrone, M; Oddi, S; Sabatucci, A; Simonetti, M | 1 |
| Abohalaka, R; Bozkurt, TE; Nemutlu, E; Onder, SC; Sahin-Erdemli, I | 1 |
| Baranowska-Kuczko, M; Biernacki, M; Niklińska, GN; Skrzydlewska, E | 1 |
| Bales, KL; Simmons, TC; Singh, ALK | 1 |
| Baranowska-Kuczko, M; Biernacki, M; Harasim-Symbor, E; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B | 1 |
| Gordon, RY; Khutsian, SS; Kitchigina, VF; Mikheeva, IB; Shubina, LV | 1 |
| Armeli, F; Bisogno, T; Businaro, R; Coccurello, R; D'Erme, M; De Caris, MG; Grieco, M; Maccarrone, M; Maggi, E; Mancini, P | 1 |
1 review(s) available for carbamates and anandamide
| Article | Year |
|---|---|
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Behavior; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Microglia; Neuralgia; Palmitic Acids; Peripheral Nerve Injuries; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Spinal Cord Injuries; TRPV Cation Channels | 2012 |
150 other study(ies) available for carbamates and anandamide
| Article | Year |
|---|---|
Unique analogues of anandamide: arachidonyl ethers and carbamates and norarachidonyl carbamates and ureas.
Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Body Temperature; Cannabinoids; Carbamates; Endocannabinoids; Hydrolysis; Ligands; Mice; Motor Activity; Polyunsaturated Alkamides; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship; Urea | 1999 |
Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.
Topics: Amidohydrolases; Arachidonic Acids; Biological Transport; Biphenyl Compounds; Brain; Carbamates; Drug Design; Endocannabinoids; Enzyme Inhibitors; Esters; Humans; In Vitro Techniques; Models, Molecular; Molecular Conformation; Polyunsaturated Alkamides; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Body Temperature; Brain; Calcium Channel Blockers; Carbamates; Chromatography, High Pressure Liquid; Drug Synergism; Duodenum; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Oleic Acids; Polyunsaturated Alkamides; PPAR alpha; Rats; Rats, Wistar | 2005 |
Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line; Cell Line, Tumor; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Gene Expression; Humans; Kidney; Liver; Lung; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Polyunsaturated Alkamides; Rats; Rats, Wistar; U937 Cells | 2005 |
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors | 2006 |
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Agonists; Carbamates; Dronabinol; Endocannabinoids; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Serotonin | 2005 |
A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Binding Sites; Calcium Channel Blockers; Carbamates; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endocannabinoids; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Microsomes; Polyunsaturated Alkamides; Scintillation Counting; Wheat Germ Agglutinins | 2006 |
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic | 2006 |
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Cannabinoids; Carbamates; Data Interpretation, Statistical; Dopamine; Endocannabinoids; Enzyme Inhibitors; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels | 2006 |
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Injections, Intraperitoneal; Male; Medial Forebrain Bundle; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Protease Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Stimulation; Synaptic Transmission | 2006 |
Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Association Learning; Avoidance Learning; Benzamides; Carbamates; Conditioning, Classical; Dose-Response Relationship, Drug; Endocannabinoids; Injections, Intraperitoneal; Lithium Chloride; Male; Nausea; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Vomiting | 2007 |
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport, Active; Brain Chemistry; Carbamates; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Furans; Hallucinogens; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; TRPV Cation Channels | 2007 |
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Capsaicin; Carbamates; Cells, Cultured; Dopamine; Drug Interactions; Endocannabinoids; Fura-2; Furans; Ganglia, Spinal; Male; Membrane Potentials; Membrane Transport Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2006 |
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Glycerides; Hydrolases; In Vitro Techniques; Lectins; Lectins, C-Type; Male; Membrane Proteins; Mesenteric Artery, Superior; Organophosphonates; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cell Surface; Vasodilation; Vasodilator Agents | 2007 |
Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blood Vessels; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Hindlimb; Indoles; Joints; Morpholines; Polyunsaturated Alkamides; Pyrazoles; Rats; Regional Blood Flow; TRPV Cation Channels; Vasodilation | 2007 |
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Emotions; Endocannabinoids; Enzyme Inhibitors; Lighting; Maze Learning; Mice; Mice, Knockout; Polyunsaturated Alkamides; Pyridines; Signal Transduction | 2007 |
The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Cell Line, Tumor; Endocannabinoids; Genistein; Hydrolysis; Mice; Nystatin; Polyunsaturated Alkamides; Progesterone; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats | 2007 |
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
Topics: Animals; Arachidonic Acids; Benzamides; Calcium; Cannabidiol; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Dronabinol; Endocannabinoids; Estrenes; Glutamic Acid; Glycerides; Hippocampus; Humans; Morpholines; Pertussis Toxin; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels | 2007 |
Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake.
Topics: 3T3-L1 Cells; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocannabinoids; Genistein; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoflavones; Male; Mice; Molecular Structure; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Rats; Tritium | 2007 |
Endocannabinoid modulation of male rat sexual behavior.
Topics: Amidohydrolases; Animals; Appetitive Behavior; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Consummatory Behavior; Dose-Response Relationship, Drug; Ejaculation; Endocannabinoids; Enzyme Inhibitors; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Sexual Behavior, Animal | 2008 |
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation | 2007 |
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.
Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Basal Ganglia; Benzamides; Benzoxazines; Cannabinoids; Capsaicin; Carbamates; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Endocannabinoids; Levodopa; Male; Morpholines; Naphthalenes; Oxidopamine; Parkinson Disease, Secondary; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2007 |
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.
Topics: Animals; Anxiety; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2008 |
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biphenyl Compounds; Brain; Calcium; Carbamates; Cell Line; Endocannabinoids; Humans; Hydrolysis; Hyperalgesia; Indoles; Mice; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Serotonin; Structure-Activity Relationship; TRPV Cation Channels | 2007 |
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry | 2007 |
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.
Topics: Adrenergic alpha-Antagonists; Alcohol Drinking; Alcoholism; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain Chemistry; Carbamates; Conditioning, Operant; Cues; Electroshock; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement Schedule; Self Administration; Stress, Psychological; Yohimbine | 2008 |
N-arachidonylethanolamide-induced increase in aqueous humor outflow facility.
Topics: Amidohydrolases; Animals; Anterior Eye Segment; Aqueous Humor; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Thin Layer; Endocannabinoids; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Swine; Trabecular Meshwork | 2008 |
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycerides; Humans; Hydrolysis; Polyunsaturated Alkamides | 2008 |
Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Carbamates; Conflict, Psychological; Data Interpretation, Statistical; Drinking; Endocannabinoids; Enzyme Inhibitors; Male; Pain Measurement; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1 | 2008 |
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Conditioning, Psychological; Dopamine; Endocannabinoids; Hydrolysis; Male; Motor Activity; Nicotine; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reward; Self Administration; Tobacco Use Disorder | 2008 |
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa | 2008 |
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Liquid; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology; Saimiri; Self Administration | 2008 |
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates.
Topics: Amidohydrolases; Amygdala; Analgesia; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fear; Male; Narcotic Antagonists; Neural Inhibition; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid; Signal Transduction | 2008 |
The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Carbamates; Cattle; Endocannabinoids; Epithelium; Fallopian Tubes; Female; Immunohistochemistry; Male; Microscopy, Fluorescence; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa | 2009 |
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.
Topics: Aging; Analysis of Variance; Animals; Arachidonic Acids; Autoradiography; Benzamides; Brain; Carbamates; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2009 |
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Topics: Acute Disease; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Blood Pressure; Cannabinoids; Carbamates; Consciousness; Endocannabinoids; Hindlimb; Hypertension; Infusions, Intravenous; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2009 |
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cisplatin; Drug Interactions; Endocannabinoids; Female; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2009 |
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain Chemistry; Carbamates; Cell Line, Tumor; Endocannabinoids; Glycine; Lipid Metabolism; Male; Metabolic Networks and Pathways; Mice; Mice, Knockout; Oxidation-Reduction; Polyunsaturated Alkamides; Rats; Recombinant Proteins | 2009 |
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Cold Temperature; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; TRPV Cation Channels | 2009 |
Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation.
Topics: Adipocytes; Adipose Tissue; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Cell Differentiation; Cyclooxygenase 2; Endocannabinoids; Enzyme Inhibitors; Flow Cytometry; Indomethacin; Male; Polyunsaturated Alkamides; PPAR gamma; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological | 2009 |
Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids.
Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Line; Cell Membrane; Cyclic N-Oxides; Endocannabinoids; Ethanolamines; Free Radical Scavengers; Glycerides; Imidazoles; Lipid Metabolism; Mice; Nitric Oxide; Nitric Oxide Donors; Palmitic Acids; Polyunsaturated Alkamides; Rats; Signal Transduction; Tritium | 2009 |
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbamates; Carboxylic Ester Hydrolases; Endocannabinoids; Glycerides; Mice; Molecular Structure; Monoacylglycerol Lipases; Motor Activity; Pain Measurement; Piperazines; Piperidines; Polyunsaturated Alkamides | 2009 |
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism.
Topics: Alanine; Arachidonic Acids; Benzamides; Calcium; Cannabinoid Receptor Modulators; Carbamates; Cell Line, Transformed; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Humans; Luminescent Proteins; Microscopy, Confocal; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Scavenger; Silicone Elastomers; Time Factors; Transfection; Tritium; Tropanes | 2010 |
The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hypothalamus; Indoles; Lipopolysaccharides; Male; Nitric Oxide; Oxytocin; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha | 2010 |
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum.
Topics: Acetylcholine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Corpus Striatum; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Neural Inhibition; Organ Culture Techniques; Polyunsaturated Alkamides; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Sensory System Agents; Synaptic Transmission; TRPV Cation Channels | 2010 |
Regulation of subthalamic neuron activity by endocannabinoids.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Endogenous cannabinoid signaling is essential for stress adaptation.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Stress, Physiological | 2010 |
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Cell Line, Transformed; Chlorocebus aethiops; COS Cells; Drug Interactions; Endocannabinoids; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Genistein; Humans; Isoflavones; Liver; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2010 |
Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Carbamates; Drug Interactions; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2011 |
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2011 |
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Compulsive Behavior; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Fluoxetine; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2011 |
The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst.
Topics: Animals; Arachidonic Acids; Benzamides; Blastocyst; Cannabinoid Receptor Modulators; Carbamates; Embryo Implantation; Endocannabinoids; Female; Immunohistochemistry; Nitric Oxide Synthase; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Uterus | 2011 |
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Antagonists; Carbamates; Drug Tolerance; Endocannabinoids; Glycerides; Hippocampus; Maze Learning; Mice; Mice, Inbred Strains; Mice, Knockout; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Receptors, Cannabinoid; Recognition, Psychology; TOR Serine-Threonine Kinases | 2011 |
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Psychological; Endocannabinoids; Ethanolamines; Exploratory Behavior; Fear; Formaldehyde; Hippocampus; Male; Motor Activity; Nociception; Pain; Periaqueductal Gray; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2012 |
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
Topics: Acute Disease; Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cotinine; Endocannabinoids; Glycerides; Implants, Experimental; Locomotion; Male; Maze Learning; Nicotine; Polyunsaturated Alkamides; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Weight Gain | 2011 |
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoids; Carbamates; Endocannabinoids; Mice; Motor Activity; Polyunsaturated Alkamides; TRPV Cation Channels | 2012 |
Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Arterioles; Benzamides; Benzoxazines; Blood Pressure; Caproates; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Flavanones; Immunohistochemistry; In Vitro Techniques; Indomethacin; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Polyunsaturated Alkamides; Rats | 2012 |
Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway.
Topics: Action Potentials; Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Fenclonine; Glycerides; Male; Microinjections; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Serotonergic Neurons; Signal Transduction; Stress, Psychological | 2012 |
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
Topics: Amides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Endocannabinoids; Ethanolamines; Male; Mass Spectrometry; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Palmitic Acids; Polyunsaturated Alkamides; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms | 2012 |
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Pain; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2012 |
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Models, Molecular; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2012 |
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Cisplatin; Disease Models, Animal; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Motor Activity; Neurites; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Drug Administration Schedule; Endocannabinoids; Ethanolamines; Inflammation; Male; Oleic Acids; Pain; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Brain; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Modulators; Carbamates; Depressive Disorder; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Frontal Lobe; Genetic Predisposition to Disease; Hippocampus; Male; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Inbred WKY; Rats, Wistar; Receptor, Cannabinoid, CB1; Species Specificity; Swimming | 2012 |
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation | 2012 |
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cells, Cultured; Cerebral Cortex; Endocannabinoids; Gene Expression Regulation, Enzymologic; Glycerides; Hippocampus; Male; Membrane Glycoproteins; Neurons; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Notch1; Signal Transduction; Up-Regulation | 2012 |
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Topics: 4-Aminopyridine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Corpus Striatum; Disease Models, Animal; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganciclovir; Glutamic Acid; Lateral Ventricles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neuroprotective Agents; Polyunsaturated Alkamides; Stem Cells; Stroke | 2012 |
Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.
Topics: Amidohydrolases; Amino Acids; Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycerides; Mice; Polyunsaturated Alkamides; Tandem Mass Spectrometry | 2013 |
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following c
Topics: Amidohydrolases; Analgesics; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoids; Carbamates; Cisplatin; Endocannabinoids; Enzyme Inhibitors; Ganglia, Spinal; Glycerides; Hyperalgesia; Lipid Metabolism; Male; Monoacylglycerol Lipases; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; TRPV Cation Channels | 2013 |
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.
Topics: Amides; Amidohydrolases; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Arachidonic Acids; Atherosclerosis; Benzamides; Carbamates; Cells, Cultured; Chemokine CXCL1; Cholesterol; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Genotype; Inflammation Mediators; Interferon-gamma; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Neutrophil Infiltration; Neutrophils; Oleic Acids; Palmitic Acids; Phenotype; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Spleen; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Topics: Active Transport, Cell Nucleus; Amidohydrolases; Antineoplastic Agents; Arachidonic Acids; Benzamides; Breast Neoplasms; Carbamates; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; MCF-7 Cells; NF-E2-Related Factor 2; Polyunsaturated Alkamides; RNA Interference; Signal Transduction; Transcription, Genetic; Transfection | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
Topics: Amides; Amidohydrolases; Analgesia; Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acids; Benzamides; Calcium Signaling; Carbamates; Diterpenes; Endocannabinoids; Ethanolamines; Flavanones; Glycerides; HEK293 Cells; Humans; Hyperalgesia; Injections, Spinal; Lipoxygenase Inhibitors; Male; Neuralgia; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Posterior Horn Cells; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2013 |
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain.
Topics: Animals; Arachidonic Acids; Benzamides; Brain Neoplasms; Cannabinoid Receptor Antagonists; Carbamates; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fibrosarcoma; Fluorescent Dyes; Ganglia, Spinal; Hyperalgesia; Indoles; Lactones; Male; Mice; Mice, Inbred C3H; Pain; Pain Threshold; Polyunsaturated Alkamides; Sensory Receptor Cells; Statistics, Nonparametric; Tritium | 2013 |
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.
Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Male; Maze Learning; Polyunsaturated Alkamides; Rats; Rats, Wistar; Signal Transduction | 2013 |
Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Gene Expression Regulation; Infusions, Intraventricular; Male; Median Eminence; Neuroprotective Agents; Nitrates; Oxytocin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; RNA, Messenger; Saline Solution, Hypertonic; Vasopressins | 2013 |
Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Carbamates; Edema; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Polyunsaturated Alkamides; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2013 |
Effects of endocannabinoid and endovanilloid systems on aversive memory extinction.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Memory; Mice, Inbred C57BL; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Social Dominance; Stress, Psychological; Time Factors; TRPV Cation Channels | 2013 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice.
Topics: Adaptation, Psychological; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Electrodes, Implanted; Electroencephalography; Electromyography; Electroshock; Endocannabinoids; Enzyme Inhibitors; Escape Reaction; Freezing Reaction, Cataleptic; Male; Mice, Inbred Strains; Motor Activity; Polyunsaturated Alkamides; Restraint, Physical; Sleep; Stress, Psychological | 2014 |
Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system.
Topics: Amidohydrolases; Animals; Anticipation, Psychological; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Lithium Chloride; Male; Monoacylglycerol Lipases; Motor Activity; Nausea; Oleic Acids; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2014 |
Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blotting, Western; Carbamates; Chromatography, Liquid; DNA Primers; Endocannabinoids; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Polyunsaturated Alkamides; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vasoconstriction | 2013 |
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Fatty Acids, Monounsaturated; Feedback, Physiological; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Stearoyl-CoA Desaturase | 2013 |
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice.
Topics: Amidohydrolases; Animals; Apolipoproteins E; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Diet, High-Fat; Dietary Fats; Endocannabinoids; Enzyme Inhibitors; Gene Expression; Macrophages; Mice; Mice, Knockout; Neutrophils; Plaque, Atherosclerotic; Polyunsaturated Alkamides; Superoxides | 2014 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbamates; Conditioning, Operant; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Implantable Neurostimulators; Injections, Intraperitoneal; Lactic Acid; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Self Administration | 2014 |
Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbamates; Cyclic AMP Response Element-Binding Protein; Endocannabinoids; Glycerides; Learning; Long-Term Potentiation; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Polyunsaturated Alkamides; Protein Processing, Post-Translational; Receptor, Cannabinoid, CB1; Spatial Memory | 2014 |
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
Topics: Acetylcysteine; Amides; Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Brain; Carbamates; Citalopram; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Expectorants; Glycerides; Imipramine; Male; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; Thiazepines | 2014 |
Effects of endogenous cannabinoid anandamide on cardiac Na⁺/Ca²⁺ exchanger.
Topics: Animals; Arachidonic Acids; Benzamides; Calcium Channel Blockers; Carbamates; Cells, Cultured; Endocannabinoids; HEK293 Cells; Humans; Male; Microscopy, Confocal; Myocytes, Cardiac; Patch-Clamp Techniques; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sodium-Calcium Exchanger | 2014 |
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Methamphetamine; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2014 |
Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Brain; Carbamates; Endocannabinoids; Enzyme Inhibitors; Hindlimb; Male; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyridines; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Treatment Outcome | 2014 |
Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood Pressure; Carbamates; Disease Models, Animal; Endocannabinoids; Female; Glycerides; Humans; Hydrolysis; Hypertension, Pregnancy-Induced; Male; Monoglycerides; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Uterine Artery; Vasoconstriction | 2014 |
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids; Female; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Monoacylglycerol Lipases; Neurons; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission | 2014 |
Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Blood-Brain Barrier; Blotting, Western; Brain Injuries; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Immunohistochemistry; Inflammation; Male; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function | 2015 |
Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.
Topics: Amidohydrolases; Arachidonic Acids; Carbamates; Cell Line, Tumor; Endocannabinoids; Humans; Magnetic Resonance Spectroscopy; Polyunsaturated Alkamides; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2014 |
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Normal aging in rats and pathological aging in human Alzheimer's disease decrease FAAH activity: modulation by cannabinoid agonists.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Carbamates; Case-Control Studies; Cerebral Cortex; Endocannabinoids; Enzyme Inhibitors; Female; Frontal Lobe; Humans; In Vitro Techniques; Male; Middle Aged; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Synaptosomes | 2014 |
Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Carbamates; Emotions; Endocannabinoids; Glycerides; Limbic System; Memory; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Receptor, Cannabinoid, CB1 | 2014 |
Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cisplatin; Endocannabinoids; Hydrolysis; Indoles; Male; Mice; Morpholines; Nerve Fibers, Unmyelinated; Nociception; Nociceptors; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Pyrazoles; Skin | 2015 |
Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Endocannabinoids; Enzyme Inhibitors; Male; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Recurrence; Self Administration; Stress, Physiological; Yohimbine | 2014 |
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Chromatography, High Pressure Liquid; Disease Models, Animal; Endocannabinoids; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Microdialysis; Norepinephrine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological; Swimming | 2015 |
Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Escape Reaction; Male; Maze Learning; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction | 2015 |
Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System.
Topics: Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Hippocampus; Indazoles; Male; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase Type II; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; RNA, Messenger; Stress, Psychological | 2015 |
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Monoacylglycerol Lipases; Nitroglycerin; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Touch; Trigeminal Nuclei | 2015 |
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats.
Topics: Aging; Animals; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Exploratory Behavior; Glycerides; Male; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Social Behavior | 2015 |
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Male; Memory; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Propofol; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Social Behavior | 2015 |
Inhibition of FAAH confers increased stem cell migration via PPARα.
Topics: Adipose Tissue; Amides; Amidohydrolases; Arachidonic Acids; Benzamides; Carbamates; Cell Movement; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Mesenchymal Stem Cells; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; PPAR alpha; Receptor, Cannabinoid, CB1; Serotonin | 2015 |
Anandamide mediates cognitive judgement bias in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Bias; Calcium Channel Blockers; Carbamates; Cognition; Conditioning, Psychological; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Judgment; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats | 2016 |
Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Brain; Carbamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Endocannabinoids; Flurbiprofen; Humans; Hydrolysis; Interferon-gamma; Ionomycin; Isoenzymes; Lipid Metabolism; Lipopolysaccharides; Male; Mice; Polyunsaturated Alkamides; Prostaglandins; RAW 264.7 Cells; Stereoisomerism | 2015 |
Endocannabinoid signaling mediates oxytocin-driven social reward.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior | 2015 |
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dronabinol; Endocannabinoids; Hippocampus; Male; Phencyclidine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation | 2016 |
Inhibition of anandamide hydrolysis dampens the neuroendocrine response to stress in neonatal rats subjected to suboptimal rearing conditions.
Topics: Adrenocorticotropic Hormone; Amidohydrolases; Animals; Animals, Newborn; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Corticosterone; Endocannabinoids; Hydrolysis; Hypothalamus; Male; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Stress, Psychological | 2016 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats.
Topics: Adaptation, Psychological; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamates; Endocannabinoids; Glycerides; Male; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction | 2016 |
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri | 2016 |
Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cues; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tobacco Use Disorder | 2016 |
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2016 |
Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
Topics: Animals; Anxiety; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Corticosterone; Emotions; Endocannabinoids; Epinephrine; Glycerides; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction | 2016 |
The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.
Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Arachidonic Acid; Arachidonic Acids; Carbamates; Carrageenan; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Endocannabinoids; Glycerides; Heroin; Hydrolysis; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neuralgia; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sciatic Nerve; Self Administration | 2017 |
The role of CB
Topics: Amidohydrolases; Arachidonic Acids; Benzamides; Benzodioxoles; Caco-2 Cells; Carbamates; Colorectal Neoplasms; Cytokines; Electric Impedance; Endocannabinoids; Gene Expression Regulation; Glycerides; Humans; Inflammation; Intestinal Mucosa; Intestines; Monoacylglycerol Lipases; Oxygen Consumption; Permeability; Piperidines; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Tissue Culture Techniques | 2017 |
Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis.
Topics: Anemia, Sickle Cell; Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Evoked Potentials; Hemoglobins; Humans; Hydrolysis; Hyperalgesia; Indoles; Male; Mice; Mice, Transgenic; Morpholines; Nerve Fibers, Unmyelinated; Nociceptors; Pain Threshold; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |
FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Body Temperature; Carbamates; Chemokine CXCL10; Corticosterone; Endocannabinoids; Estradiol; Ethanolamines; Female; Glycerides; Immunologic Factors; Interferons; Male; Monoacylglycerol Lipases; NF-kappa B; Oleic Acids; Palmitic Acids; Poly I-C; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Sex Factors; Signal Transduction; Succinimides; Toll-Like Receptor 3 | 2018 |
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Agonists; Carbamates; Diazepam; Endocannabinoids; Fear; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents.
Topics: Acute Disease; Amides; Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety Disorders; Arachidonic Acids; Cannabinoid Receptor Agonists; Carbamates; Chronic Disease; Dioxanes; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Female; Gene Expression; Male; Mice; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Receptors, Cannabinoid; Stress, Psychological | 2018 |
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Benzoxazines; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Startle; Stress Disorders, Post-Traumatic | 2018 |
Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Feeding Behavior; Glycerides; Hippocampus; Locomotion; Male; Neuralgia; Neurogenesis; Pain Threshold; Polyunsaturated Alkamides; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Swimming | 2019 |
Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling.
Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Carbamates; Dentate Gyrus; Depression; Dronabinol; Endocannabinoids; Female; Marijuana Abuse; Neurogenesis; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sexual Maturation; Signal Transduction; Synapses; Tissue Culture Techniques | 2018 |
Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats.
Topics: Amidohydrolases; Animals; Anorexia; Arachidonic Acids; Carbamates; Duodenum; Eating; Endocannabinoids; Glycerides; Homeostasis; Jejunum; Male; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Stress, Psychological; Succinimides | 2019 |
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Chemokines; Cytokines; Dentate Gyrus; Endocannabinoids; Enzyme Inhibitors; Ethanol; Gene Expression; Glial Fibrillary Acidic Protein; Hippocampus; Male; Memory; Memory, Long-Term; Memory, Short-Term; Microglia; Nitric Oxide Synthase Type II; Phenotype; Polyunsaturated Alkamides; Rats, Wistar; Receptors, Chemokine | 2018 |
Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Desoxycorticosterone Acetate; Endocannabinoids; Glycerides; Heart; Hypertension; Male; Myocardium; Oxidation-Reduction; Oxidative Stress; Polyunsaturated Alkamides; Rats, Inbred SHR; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Brain; Carbamates; Central Nervous System Agents; Conditioning, Psychological; Endocannabinoids; Fear; Glycerides; Male; Motor Activity; Nociception; Piperidines; Polyunsaturated Alkamides; Random Allocation; Rats, Wistar | 2019 |
Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug Synergism; Endocannabinoids; Female; Glutarates; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Quinolinic Acid; Rats; Rats, Inbred WF; Receptors, Cannabinoid | 2019 |
Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Arterial Pressure; Behavior, Animal; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Endocannabinoids; Heart Rate; Hippocampus; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Restraint, Physical; Skin Temperature; Stress, Psychological | 2019 |
Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory.
Topics: Animals; Arachidonic Acids; Arousal; Benzamides; Carbamates; Circadian Rhythm; Corticosterone; Emotions; Endocannabinoids; Male; Memory, Short-Term; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2019 |
Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Female; Long-Term Synaptic Depression; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protein Transport; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Social Behavior; Valproic Acid | 2020 |
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
Topics: Amygdala; Animals; Arachidonic Acids; Arousal; Basolateral Nuclear Complex; Behavior, Animal; Benzamides; Carbamates; Depression; Disease Models, Animal; Endocannabinoids; Extinction, Psychological; Neuropeptide Y; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide Y; Reflex, Startle; Social Behavior; Stress Disorders, Post-Traumatic | 2020 |
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats.
Topics: Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Carbamates; Endocannabinoids; Enzyme Activation; Female; Hippocampus; Polyunsaturated Alkamides; Rats; Social Isolation | 2020 |
The endocannabinoid hydrolase FAAH is an allosteric enzyme.
Topics: Allosteric Regulation; Allosteric Site; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biocatalysis; Carbamates; Catalytic Domain; Drug Design; Endocannabinoids; Enzyme Assays; Humans; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Mutation; Polyunsaturated Alkamides; Protein Subunits; Rats | 2020 |
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Cytokines; Endocannabinoids; Glycerides; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Monoacylglycerol Lipases; Piperidines; Pneumonia; Polyunsaturated Alkamides; Respiratory Hypersensitivity | 2020 |
The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension.
Topics: Animals; Arachidonic Acids; Benzamides; Brain; Carbamates; Disease Models, Animal; Endocannabinoids; Hypertension; Injections, Intraperitoneal; Male; Malondialdehyde; Oxidation-Reduction; Phospholipids; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2020 |
Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster).
Topics: Animals; Anxiety; Arachidonic Acids; Arvicolinae; Behavior, Animal; Benzamides; Carbamates; Endocannabinoids; Exploratory Behavior; Female; Male; Maze Learning; Nucleus Accumbens; Pair Bond; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Oxytocin; Social Behavior | 2021 |
Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Carbamates; Endocannabinoids; Essential Hypertension; Hypertension; Male; Mesenteric Arteries; Nitroprusside; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Vasoconstriction; Vasodilation | 2021 |
Kainate-Induced Degeneration of Hippocampal Neurons. Protective Effect of Activation of the Endocannabinoid System.
Topics: Animals; Arachidonic Acids; Autophagosomes; Benzamides; CA3 Region, Hippocampal; Carbamates; Dentate Gyrus; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Golgi Apparatus; Kainic Acid; Lysosomes; Male; Microscopy, Electron; Necrosis; Nerve Degeneration; Polyunsaturated Alkamides; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus | 2021 |
Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization.
Topics: Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Animals; Arachidonic Acids; Benzamides; Carbamates; Cell Line; Cell Movement; Cell Polarity; Cytokines; Cytoskeleton; Disease Models, Animal; Endocannabinoids; Mice; Microglia; Polyunsaturated Alkamides | 2021 |