carbachol has been researched along with n-methylscopolamine in 208 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 71 (34.13) | 18.7374 |
| 1990's | 104 (50.00) | 18.2507 |
| 2000's | 28 (13.46) | 29.6817 |
| 2010's | 5 (2.40) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Augelli-Szafran, CE; Jaen, JC; Moreland, DW; Nelson, CB; Penvose-Yi, JR; Schwarz, RD | 1 |
| Bloodworth, LM; Hamdan, FF; Han, SJ; Jacobson, KA; Kim, SK; Li, JH; Wess, J; Zhang, X | 1 |
| Bonnet, D; Daval, SB; Galzi, JL; Hibert, M; Ilien, B; Kellenberger, E; Valant, C | 1 |
| Frucht, H; Gazdar, AF; Jensen, RT; Oie, H; Park, JA | 1 |
| Aly, MH; el-Fakahany, EE; Forray, C; Mohamed, AS | 1 |
| Bali, JP; Cros, G; Serrano, JJ; Soulié, ML | 1 |
| Lambert, DG; Nahorski, SR; Tobin, AB | 1 |
| Kikuchi de Beltrán, K; Kobayashi, M; Koshida, Y; Koshikawa, N; Saigusa, T; Watanabe, K | 1 |
| Baumgold, J; Boyd, VL; Chiang, PK; Gordon, RK; Leader, H; Newman, AH; Smejkal, RM | 1 |
| Flynn, DD; Mash, DC; Vaishnav, AA | 1 |
| Lameh, J; Moro, O; Philip, M; Ramachandran, J; Sadée, W; Sharma, YK | 1 |
| Pechnick, RN; Vargas, HM | 1 |
| Chidiac, P; Nagy, A; Sole, MJ; Wells, JW | 1 |
| Fujii, M; Fujisawa, T; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Adachi, H; Aoki, E; Honda, T; Katsushima, S; Konishi, J; Noguchi, M; Onishi, S; Sato, S | 1 |
| Collins, SP; Roberts, ML | 1 |
| Atkins, PT; Kitai, ST; Nishi, K; Surmeier, DJ | 1 |
| el-Fakahany, EE; Hu, J; Wang, SZ | 1 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y; Yazu, T | 1 |
| Hootman, SR; Kovalcik, SA; Valles, SM | 1 |
| Hersey, SJ; Kajimura, M; Sachs, G; Scott, DR; Wilkes, JM | 1 |
| Brann, MR; Gutkind, JS; Novotny, EA; Robbins, KC | 1 |
| Endou, M | 1 |
| Yang, CM | 1 |
| Müller, WE; Stoll, L | 1 |
| Gomez, A; Laukonnen, S; Marquez, E; Martos, F; Pavia, J; Rius, F; Sanchez de la Cuesta, F | 1 |
| Akins, PT; Kitai, ST; Surmeier, DJ | 1 |
| el-Fakahany, EE; Lai, WS | 1 |
| el-Fakahany, EE; Lai, WS; Rogers, TB | 1 |
| Kopp, R; Mayer, P; Pfeiffer, A | 1 |
| Abraham, R; Enloes, L; Kanba, KS; Kanba, S; Mackey, S; McKinney, M; Nomura, S; Pfenning, M; Richelson, E | 1 |
| Bonner, TI; Brann, MR; Dörje, F; Wess, J | 1 |
| Gardner, JD; Jensen, RT; Murakami, M; Sharp, C; Vinayek, R | 1 |
| Uchida, S; Yoshida, H; Zhou, XM | 1 |
| Abello, J; Bernard, C; Chayvialle, JA; Cuber, JC; Philippe, J; Roche, C | 1 |
| Hanack, C; Herawi, M; Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R | 1 |
| Habara, Y; Hootman, SR; Verme, TB | 1 |
| Horackova, M; Robinson, B; Wilkinson, M | 1 |
| Akerman, KE; Heikkilä, JE | 1 |
| Horwitz, J | 1 |
| Hoover, RK; Toews, ML | 1 |
| Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E | 1 |
| Boer, R; Bönisch, H; Dobler, M; Schudt, C | 1 |
| Ehlert, FJ; Rathbun, BE | 1 |
| Houlihan, MJ; Powers, RE; Saluja, AK; Steer, ML | 1 |
| Brown, ME; Hootman, SR; Logsdon, CD; Williams, JA | 1 |
| Habara, Y; Hootman, SR; Williams, JA | 1 |
| Ackerman, MS; Korc, M; Roeske, WR | 1 |
| Asselin, J; Larose, L; Morisset, J | 1 |
| Eglen, RM; Kenny, BA; Michel, AD; Whiting, RL | 1 |
| Larose, L; Loiselle, J; Morisset, J | 1 |
| Hawthorne, JN; Simmonds, SH; Yagisawa, H | 1 |
| Christophe, J; Dehaye, JP; Marino, A; Poloczek, P; Soukias, Y; Winand, J | 1 |
| Baumgold, J; White, T | 1 |
| Anthony, BL; Aronstam, RS; Dennison, RL | 2 |
| Cioffi, CL; el-Fakahany, EE | 2 |
| Berman, JD; Middleton, W; Ray, P | 1 |
| Ackerman, MS; Heck, RJ; Korc, M; Roeske, WR | 1 |
| Cornett, CM; Eglen, RM; Kunysz, EA; Michel, AD; Whiting, RL | 1 |
| Nahorski, SR; Rooney, TA | 1 |
| Morrow, C; Murphy, S; Pearce, B | 1 |
| Ek, B; Nahorski, S | 1 |
| Amrhein, CL; Cioffi, CL; el-Fakahany, EE; McKinney, M; Richelson, E; Stenstrom, S; Surichamorn, W | 1 |
| Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N | 1 |
| McKinney, M; Richelson, E; Stenstrom, S | 2 |
| Brown, JH; Masters, SB; Quinn, MT | 1 |
| McKinney, M; Richelson, E | 1 |
| Chuang, DM; Xu, J | 1 |
| Anthony, BL; Aronstam, RS | 1 |
| Lüllmann, H; Mohr, K; Pfeffer, J | 1 |
| Abdel-Latif, AA; Honkanen, RE | 1 |
| Grill, V; Ostenson, CG | 1 |
| Dwyer, TM; Farley, JM; Yang, CM | 1 |
| Fisher, SK | 1 |
| Aguilar, JS; De Robertis, E; Ochoa, EL | 1 |
| Christophe, J; Gillard, M; Waelbroeck, M | 1 |
| Bali, JP; Baudiere, B; Giraldo, E; Ladinsky, H; Monferini, E | 1 |
| Cortés, R; Cymerman, U; Palacios, JM; Skangiel-Kramska, J | 1 |
| Dohanich, GP; Halpain, S; Lambdin, LT; McEwen, BS | 1 |
| Burgen, AS | 1 |
| Batink, HD; Davidesko, D; de Jonge, A; Doods, HN; Mathy, MJ; van Zwieten, PA | 1 |
| Chien, JL; Warren, JR | 1 |
| Baker, SP; Posner, P | 1 |
| Carswell, H; Galione, AG; Young, JM | 1 |
| el-Fakahany, EE; Lee, JH | 2 |
| Aronstam, RS; Kirby, ML; Smith, MD | 1 |
| Aronstam, RS; Parthasarthy, N; Wenger, DA | 1 |
| El-Fakahany, EE; Feigenbaum, P | 2 |
| Harden, TK; Petch, LA; Traynelis, SF; Waldo, GL | 1 |
| Ehlert, FJ | 1 |
| Kuhar, MJ; Wamsley, JK; Zarbin, MA | 2 |
| Appert, HE; Budd, GC; Chiu, TH; Howard, JM; Leonardi, AJ | 1 |
| Blanchard, L; Dumont, Y; Fregeau, C; Larose, L; Morisset, J; Poirier, GG | 1 |
| Christophe, J; Dehaye, JP; Poloczek, P; Winand, J | 1 |
| Aronstam, RS; Parthasarathy, N; Pickard, C | 1 |
| Baissat, J; Chassaing, C; Duchêne-Marullaz, P; Dureng, G | 1 |
| Nathanson, NM | 1 |
| Albinus, M; Winne, D | 1 |
| Fischbach, GD; Siegel, RE | 1 |
| Klein, WL; Siman, RG | 1 |
| Gossuin, A; Laduron, PM; Maloteaux, JM; Pauwels, PJ | 1 |
| Dziekan, LC; Galper, JB; Smith, TW | 1 |
| Bárány, E; Berrie, CP; Birdsall, NJ; Burgen, AS; Hulme, EC | 1 |
| Hammer, R | 1 |
| Birdsall, NJ; Erlanger, BF; Lester, HA; Nargeot, J; Stockton, J; Wassermann, NH | 1 |
| Dziekan, LC; Galper, JB; O'Hara, DS; Smith, TW | 1 |
| Dziekan, LC; Galper, JB; Miura, DS; Smith, TW | 1 |
| Birdsall, NJ; Kuhar, MJ; Wamsley, JK; Zarbin, MA | 1 |
| Leppik, R; van Giersbergen, PL | 1 |
| Burford, NT; Nahorski, SR; Tobin, AB | 1 |
| Liu, J; Schöneberg, T; Wess, J | 1 |
| Maggio, R; Nanavati, S; Vogel, Z; Wess, J | 1 |
| Chowdhury, P; Doi, R; Inoue, K; Kaji, H; Rayford, PL | 1 |
| el-Fakahany, EE; Wang, SZ | 1 |
| Habara, Y; Kanno, T | 1 |
| Chowdhury, P; Doi, R; Rayford, PL | 1 |
| Busik, J; Habara, Y; Ikei, N; Kanno, T | 1 |
| Curtis, CA; Hulme, EC; Jones, PG | 1 |
| Haga, T; Kameyama, K; Kurose, H; Nagao, T; Tsuga, H | 1 |
| Cools, AR; de Beltrán, KK; Kobayashi, M; Koshikawa, N; Miwa, Y | 1 |
| Jones, SB; Liston, DR; Ward, KM; Zorn, SH | 1 |
| Blüml, K; Mutschler, E; Wess, J | 3 |
| Abello, J; Bernard, C; Bosshard, A; Chayvialle, JA; Cuber, JC; Ye, F | 1 |
| Goldman, PS; Nathanson, NM | 1 |
| Baum, BJ; Eckelman, WC; Hiramatsu, Y | 1 |
| Kikuchi de Beltrán, K; Kobayashi, M; Koshikawa, N; Miwa, Y; Stephenson, JD | 1 |
| Greten, H; Mirau, S; Raedler, A; Sievers, J; von Schrenck, T | 1 |
| Baum, BJ; Dai, Y | 1 |
| Hermans, E; Maloteaux, JM | 1 |
| Maggio, R; Vogel, Z; Wess, J | 1 |
| Antonsson, BM; Ek, B | 1 |
| Eglen, RM; Sharif, NA; To, ZP | 1 |
| Consolo, S; Garcia Ruiz, AJ; La Porta, C; Ladinsky, H; Zambelli, M | 1 |
| Bado, A; Cherifi, Y; Laigneau, JP; Lewin, MJ; Moizo, L | 1 |
| Bacáková, L; el-Fakahany, EE; Jakubík, J; Tucek, S | 1 |
| Jones, SB; King, LB | 1 |
| Olianas, MC; Onali, P | 2 |
| Brann, MR; Burstein, ES; Spalding, TA | 2 |
| Goldman, PS; Nathanson, NM; Schlador, ML; Shapiro, RA | 1 |
| Barnes, PJ; Haddad, EB; Mak, JC; Rousell, J | 1 |
| Lameh, J; Tolbert, LM | 1 |
| Alessandro, R; Brilley, E; Felder, CC; Jacobs, W; Kohn, EC; Probst, J | 1 |
| Challiss, RA; Nahorski, SR; Stuart, JA; Willars, GB | 1 |
| Cheng, E; Cline, RT; Fraser, CM; Geoghagen, NS; Lee, NH | 1 |
| Lin, WW; Wang, CW | 1 |
| Horowitz, M; Kaspler, P; Marmary, Y; Oron, Y | 1 |
| Dehaye, JP; Grosflis, K; Lenoble, S; Métioui, M | 1 |
| Buccafusco, JJ; Feldman, DS; Terry, AV | 1 |
| Gronroos, J; Huupponen, R; Kaila, T; Laine, VJ; Nevalainen, TJ | 1 |
| el-Fakahany, EE; Lee, SY; Zhu, SZ | 1 |
| Barbier, P; Corsini, GU; Fornai, F; Maggio, R | 1 |
| Chidiac, P; Green, MA; Wells, JW | 1 |
| Haga, T; Honma, T; Kameyama, K; Lameh, J; Sadée, W; Tsuga, H | 1 |
| Huang, CL; Lee, HM; Lin, CH; Tsai, KJ; Tung, CS | 1 |
| Christopoulos, A; El-Fakahany, EE; Pierce, TL; Sorman, JL | 1 |
| Bartoszko-Malik, A; Raufman, JP; Zimniak, P | 1 |
| Harbon, S; Lajat, S; Tanfin, Z | 1 |
| Lisá, V; Myslivecek, J; Trojan, S; Tucek, S | 1 |
| Fu, HM; Fu, ML; Hjalmarson, A; Matsui, S; Wallukat, G | 1 |
| Christopoulos, A; El-Fakahany, EE; Parsons, AM | 1 |
| Schöneberg, T; Soldner, A; Wess, J; Zeng, FY | 1 |
| Detjen, K; Logsdon, CD; Nicke, B | 1 |
| El-Fakahany, EE; Lysíková, M; Michal, P; Tucek, S | 1 |
| Chien, CS; Chiu, CT; Lin, CC; Pan, SL; Shyr, MH; Tan, PP; Wang, CC; Yang, CM | 1 |
| Branski, L; Ilouz, N; Linial, M; Parnas, H; Parnis, J | 1 |
| Azpiazu, I; Cruzblanca, H; Gautam, N; Li, P; Linder, M; Zhuo, M | 1 |
| Aihara, O; Fukamauchi, F; Kusakabe, M | 1 |
| Alling, C; Andersson, A; Caron, M | 1 |
| Adem, A; Karlsson, E; Maullu, C; Mulugeta, E; Olianas, MC; Onali, P | 1 |
| Frucht, H; Yang, WL | 1 |
| Lysíková, M; Michal, P; Tucek, S | 1 |
| Christopoulos, A; Lanzafame, A; Mitchelson, F | 1 |
| Endou, M; Gamoh, M; Hirose, Y; Miwa, T; Nakaya, H; Okumura, F; Tanito, Y | 1 |
| Hanai, T; Higashira, H; Kiwamoto, H; Kurita, T; Ma, F-; Park, YC; Ukai, Y | 1 |
| de Azevedo, LC; Häckl, LP; Marino-Neto, J; Paschoalini, MA; Zizemer, JR | 1 |
| Park, PS; Sum, CS; Wells, JW | 1 |
| Bräuner-Osborne, H; Falch, E; Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Mikkelsen, I | 1 |
| El-Fakahany, EE; Grant, MK | 1 |
| Azpiazu, I; Gautam, N | 1 |
| Dolezal, V; El-Fakahany, EE; Jakubík, J | 1 |
| Arias-Montaño, JA; Sánchez-Lemus, E | 1 |
| Braeter, M; Hakenberg, OW; Kelly, LU; Ravens, U; Waelbroeck, M; Weiss, A; Wuest, M | 1 |
| Hatanaka, T; Miyata, K; Noguchi, Y; Ohtake, A; Okutsu, H; Saitoh, C; Sasamata, M; Sato, S; Suzuki, M; Ukai, M; Yuyama, H | 1 |
| Akamatsu, Y; Nakae, K; Nishimura, Y; Ohba, S | 1 |
| Dadon, M; Grossman, Y; Heldman, E; Leibovich, M; Saar, D; Sharabani, H | 1 |
| Akiho, H; Al-Kaabi, A; Blennerhassett, P; Collins, SM; Deng, Y; Khan, WI | 1 |
| Ehlert, FJ; Sawyer, GW; Shults, CA | 1 |
| De Lorme, KC; El-Fakahany, EE; Grant, MK; Noetzel, MJ; Polson, SB | 1 |
| Akino, H; Anisuzzaman, AS; Morishima, S; Muramatsu, I; Sathi, ZS; Suzuki, F; Tanaka, T; Yokoyama, O; Yoshiki, H | 1 |
| Avlani, VA; Christopoulos, A; McLoughlin, DJ; Sexton, PM | 1 |
| Liu, J; Pope, CN; Udarbe Zamora, EM | 1 |
| Dolezal, V; El-Fakahany, EE; Michal, P; Rudajev, V | 1 |
| El-Fakahany, EE; Grant, MK; Noetzel, MJ | 1 |
| Anisuzzaman, AS; Muramatsu, I; Nishimune, A; Uwada, J; Yoshiki, H | 1 |
| Doležal, V; El-Fakahany, EE; Jakubík, J; Janíčková, H; Randáková, A | 1 |
| Anisuzzaman, AS; Ikeda, T; Itoh, H; Koshiji, T; Muramatsu, I; Nishimune, A; Sasaki, M; Uwada, J; Yoshiki, H | 1 |
| Albold, S; Christopoulos, A; Clark, MJ; Eitel, K; Fish, I; Gmeiner, P; Huebner, H; Möller, D; Shoichet, BK; Stößel, A; Sunahara, RK; Valant, C | 1 |
1 review(s) available for carbachol and n-methylscopolamine
| Article | Year |
|---|---|
Cardioselective muscarinic antagonists.
Topics: Animals; Carbachol; Cardiotonic Agents; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Dose-Response Relationship, Drug; Heart; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Pirenzepine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
207 other study(ies) available for carbachol and n-methylscopolamine
| Article | Year |
|---|---|
Identification and characterization of m4 selective muscarinic antagonists.
Topics: Isoquinolines; Muscarinic Antagonists; Protein Binding; Receptor, Muscarinic M4; Receptors, Muscarinic | 1998 |
Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cysteine; Ligands; Models, Molecular; Mutation, Missense; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptor, Muscarinic M3 | 2007 |
Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors.
Topics: Allosteric Regulation; Calcium; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Green Fluorescent Proteins; HEK293 Cells; Humans; Models, Molecular; Molecular Probes; Piperidines; Radioligand Assay; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Rhodamines; Solubility; Structure-Activity Relationship | 2012 |
Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells.
Topics: Bombesin; Calcium; Carbachol; Colonic Neoplasms; Humans; Inositol 1,4,5-Trisphosphate; N-Methylscopolamine; Receptors, Bombesin; Receptors, Gastrointestinal Hormone; Receptors, Neurotransmitter; Scopolamine Derivatives; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Lack of intrinsic activity and significant subtype selectivity of SR 95639A at muscarinic receptors.
Topics: Acetylcholine; Animals; Binding Sites; Carbachol; Cerebral Cortex; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Female; Hydrolysis; Inositol Phosphates; Male; Morpholines; N-Methylscopolamine; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Transfection | 1992 |
Impairment of contractile response to carbachol and muscarinic receptor coupling in gastric antral smooth muscle cells isolated from diabetic streptozotocin-treated rats and db/db mice.
Topics: Animals; Carbachol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Erythromycin; Female; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pyloric Antrum; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Streptozocin | 1992 |
Rapid desensitization of muscarinic m3 receptor-stimulated polyphosphoinositide responses.
Topics: Animals; Carbachol; Cell Membrane; CHO Cells; Cricetinae; Humans; Inositol 1,4,5-Trisphosphate; N-Methylscopolamine; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Cholinergic/dopaminergic interaction in the rat striatum assessed from drug-induced repetitive oral movements.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Carbachol; Corpus Striatum; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Scopolamine Derivatives; Stereotyped Behavior | 1992 |
Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).
Topics: Acetylcholine; alpha-Amylases; Animals; Binding, Competitive; Carbachol; Cyclohexanes; Guinea Pigs; Ileum; Male; Molecular Structure; Muscarine; Muscle Contraction; N-Methylscopolamine; Pancreas; Phenylpropionates; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Transfection | 1992 |
Interactions of cocaine with primary and secondary recognition sites on muscarinic receptors.
Topics: Adult; Allosteric Site; Binding Sites; Brain Stem; Carbachol; Cocaine; Ethylmaleimide; Guanine Nucleotides; Humans; In Vitro Techniques; Kinetics; Male; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop.
Topics: Amino Acid Sequence; Binding Sites; Calcimycin; Carbachol; Cells, Cultured; Cytoplasm; Humans; Kidney; Molecular Sequence Data; Mutation; N-Methylscopolamine; Phosphorylation; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Sequence Alignment; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1992 |
Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands.
Topics: Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Dioxolanes; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pentazocine; Phosphatidylinositols; Piperidines; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine; Scopolamine Derivatives | 1991 |
Inefficient muscarinic transduction in cardiomyopathic Syrian hamsters.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cardiomyopathies; Colforsin; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Isoproterenol; Mesocricetus; N-Methylscopolamine; Parasympatholytics; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction | 1991 |
Action of a new cholinergic agonist, aclatonium napadisilate, on isolated rat pancreatic acini.
Topics: Acetylcholine; Amylases; Animals; Calcium; Calcium Radioisotopes; Carbachol; Male; N-Methylscopolamine; Pancreas; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Cholecystokinin-induced regulation of muscarinic receptor on dispersed pancreatic acini.
Topics: Amylases; Animals; Binding Sites; Carbachol; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Sincalide; Tritium | 1990 |
Metalloendopeptidase inhibitors and stimulus-secretion coupling in the mouse exocrine pancreas.
Topics: Amylases; Animals; Bombesin; Bucladesine; Calcimycin; Carbachol; Dipeptides; Metalloendopeptidases; Mice; N-Methylscopolamine; Pancreas; Phenanthrolines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Sincalide | 1990 |
Muscarinic regulation of cyclic AMP metabolism in rat neostriatal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cells, Cultured; Corpus Striatum; Cyclic AMP; Embryo, Mammalian; Kinetics; N-Methylscopolamine; Neurons; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cell Line; Cricetinae; Cricetulus; Down-Regulation; Female; Hydrolysis; N-Methylscopolamine; Parasympatholytics; Phosphatidylinositols; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
Effects of calcium-channel blockers on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: Amylases; Animals; Bombesin; Calcium; Calcium Channel Blockers; Carbachol; Ceruletide; Cytosol; Diltiazem; In Vitro Techniques; Male; N-Methylscopolamine; Pancreas; Peptide Fragments; Rats; Rats, Inbred Strains; Scopolamine Derivatives; Verapamil | 1991 |
Mechanism of agonist-induced downregulation of muscarinic receptors in rat pancreatic acini.
Topics: Animals; Binding Sites; Carbachol; Cells, Cultured; Down-Regulation; Kinetics; N-Methylscopolamine; Pancreas; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives | 1991 |
Muscarinic responses of gastric parietal cells.
Topics: Aminopyrine; Animals; Arachidonic Acids; Calcium; Carbachol; Glucose; Image Processing, Computer-Assisted; Ionomycin; N-Methylscopolamine; Parasympatholytics; Parietal Cells, Gastric; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1991 |
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Cell Division; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Genetic Vectors; GTP-Binding Proteins; Humans; Mice; N-Methylscopolamine; Oncogenes; Phosphatidylinositols; Plasmids; Receptors, Muscarinic; Scopolamine Derivatives; Transfection | 1991 |
[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors].
Topics: Animals; Binding, Competitive; Carbachol; Disopyramide; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Myocardial Contraction; N-Methylscopolamine; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic; Scopolamine Derivatives | 1991 |
Characterization of muscarinic receptors in dog tracheal smooth muscle cells.
Topics: Animals; Atropine; Carbachol; Diamines; Dogs; In Vitro Techniques; Kinetics; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Trachea | 1991 |
In vitro down-regulation predicts agonist efficacy at central muscarinic cholinergic receptors.
Topics: Animals; Brain; Carbachol; Down-Regulation; Female; Inositol Phosphates; Mice; Mice, Inbred Strains; N-Methylscopolamine; Neurons; Parasympathomimetics; Receptors, Muscarinic; Scopolamine Derivatives | 1991 |
Circadian rhythm in muscarinic receptor subtypes in rat forebrain.
Topics: Animals; Brain; Carbachol; Circadian Rhythm; In Vitro Techniques; Kinetics; Male; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
M1 muscarinic acetylcholine receptor in cultured rat neostriatum regulates phosphoinositide hydrolysis.
Topics: Animals; Binding, Competitive; Carbachol; Cells, Cultured; Corpus Striatum; Fetus; Hydrolysis; Inositol Phosphates; Kinetics; N-Methylscopolamine; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Antagonism by the diacylglycerol kinase inhibitor R59 022 of muscarinic receptor-mediated cyclic GMP formation and binding of [3H]N-methylscopolamine.
Topics: Animals; Binding, Competitive; Carbachol; Cyclic GMP; Diacylglycerol Kinase; Mice; Muscarinic Antagonists; N-Methylscopolamine; Phosphotransferases; Pyrimidinones; Receptors, Muscarinic; Scopolamine Derivatives; Thiazoles; Tumor Cells, Cultured | 1990 |
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regulation; Isoquinolines; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells.
Topics: Carbachol; Colonic Neoplasms; Enzyme Activation; GTP-Binding Proteins; Humans; Hydrolysis; Inositol; Ionomycin; N-Methylscopolamine; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity.
Topics: Animals; Carbachol; Down-Regulation; Guanosine Monophosphate; Inositol Phosphates; Mice; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers.
Topics: Adenylate Cyclase Toxin; Animals; Carbachol; Cyclic AMP; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Mice; N-Methylscopolamine; Pertussis Toxin; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Second Messenger Systems; Virulence Factors, Bordetella | 1990 |
Carbachol-induced down-regulation of receptors for pancreatic secretagogues.
Topics: Animals; Carbachol; Down-Regulation; Guinea Pigs; Male; N-Methylscopolamine; Pancreas; Parasympatholytics; Receptors, Bombesin; Receptors, Cholecystokinin; Receptors, Muscarinic; Receptors, Neurotransmitter; Scopolamine Derivatives | 1990 |
Disappearance in high-K+ medium of receptor-mediated inhibition of adenylate cyclase in guinea-pig cortical slices.
Topics: Acetylcholinesterase; Adenylyl Cyclase Inhibitors; Animals; Calcium; Carbachol; Cerebral Cortex; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Male; N-Methylscopolamine; Potassium; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction | 1990 |
Characterization of muscarinic acetylcholine receptors on the rat pancreatic gastrin-producing cell line B6 RIN.
Topics: Animals; Binding, Competitive; Calcium; Carbachol; Cell Line; Gastrins; N-Methylscopolamine; Pancreas; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors.
Topics: Carbachol; Gastric Mucosa; Humans; In Vitro Techniques; N-Methylscopolamine; Parasympatholytics; Piperazines; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Effects of cycloheximide and tunicamycin on cell surface expression of pancreatic muscarinic acetylcholine receptors.
Topics: Animals; Carbachol; Cell Membrane; Cells, Cultured; Cycloheximide; Down-Regulation; Guinea Pigs; In Vitro Techniques; Kinetics; Leucine; Male; Mannose; N-Methylscopolamine; Pancreas; Parasympatholytics; Receptors, Muscarinic; Scopolamine Derivatives; Tunicamycin | 1990 |
Characterization and agonist regulation of muscarinic ([3H]N-methyl scopolamine) receptors in isolated ventricular myocytes from rat.
Topics: Animals; Bacitracin; Binding, Competitive; Carbachol; Down-Regulation; Endocytosis; In Vitro Techniques; Male; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Radioligand Assay; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
12-O-tetradecanoylphorbol 13-acetate and forskolin modify muscarinic receptor-linked Ca2+ mobilization in SH-SY5Y neuroblastoma cells through different mechanisms.
Topics: Benzofurans; Binding, Competitive; Biomechanical Phenomena; Calcium; Carbachol; Colforsin; Cytosol; Fluorescent Dyes; Fura-2; Ionomycin; Membrane Potentials; N-Methylscopolamine; Neuroblastoma; Osmolar Concentration; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Carbachol and bradykinin increase the production of diacylglycerol from sources other than inositol-containing phospholipids in PC12 cells.
Topics: Bradykinin; Calcium; Carbachol; Diglycerides; Glycerides; Inositol; Inositol Phosphates; N-Methylscopolamine; Osmolar Concentration; Parasympathomimetics; Pertussis Toxin; Pheochromocytoma; Phospholipids; Scopolamine Derivatives; Triglycerides; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1990 |
Activation of protein kinase C inhibits internalization and downregulation of muscarinic receptors in 1321N1 human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cycloheximide; Down-Regulation; Enzyme Activation; Humans; N-Methylscopolamine; Protein Kinase C; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland.
Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Pharmacological characterization of muscarine receptors of PC12 (rat phaeochromocytoma) cells.
Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Carbachol; Cell Membrane; Cerebral Cortex; Guinea Pigs; Myocardium; N-Methylscopolamine; Norepinephrine; Parasympatholytics; Pheochromocytoma; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives; Tumor Cells, Cultured | 1990 |
Signaling through the muscarinic receptor-adenylate cyclase system of the heart is buffered against GTP over a range of concentrations.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis.
Topics: Aminoquinolines; Amylases; Animals; Calcimycin; Calcium; Carbachol; Choline Deficiency; Diglycerides; Enzyme Activation; Ethionine; Female; Fluorescence; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mice; N-Methylscopolamine; Pancreas; Pancreatitis; Protein Kinase C; Scopolamine Derivatives; Sugar Phosphates; Tritium; Type C Phospholipases | 1986 |
Regulation of muscarinic acetylcholine receptors in cultured guinea pig pancreatic acini.
Topics: Amylases; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Cells, Cultured; Guinea Pigs; Methacholine Chloride; Methacholine Compounds; N-Methylscopolamine; Pancreas; Parasympatholytics; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Sincalide | 1986 |
Antimuscarinic effects of chloroquine in rat pancreatic acini.
Topics: Amylases; Animals; Carbachol; Chloroquine; In Vitro Techniques; N-Methylscopolamine; Pancreas; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
A cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini.
Topics: Amylases; Animals; Atropine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Short-term cholinergic desensitization of rat pancreatic secretory response.
Topics: Amylases; Animals; Calcimycin; Calcium; Carbachol; Ceruletide; Dose-Response Relationship, Drug; In Vitro Techniques; N-Methylscopolamine; Pancreas; Pancreatic Juice; Rats; Scopolamine Derivatives; Secretory Rate; Tetradecanoylphorbol Acetate | 1987 |
Muscarinic activity of McN-A-343 and its value in muscarinic receptor classification.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Cerebral Cortex; Guinea Pigs; In Vitro Techniques; Male; Myocardium; N-Methylscopolamine; Parasympatholytics; Quaternary Ammonium Compounds; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Contraindication for osmotic mini-pump in the abdominal cavity to study muscarinic cholinergic control of pancreatic enzyme secretion and muscarinic receptors.
Topics: Amylases; Animals; Carbachol; Infusion Pumps; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
The muscarinic receptor of rat pituitary GH3 cells is coupled with adenylate cyclase inhibition, but not with phosphoinositide turnover.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carbachol; Inositol Phosphates; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Pituitary Gland; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1988 |
Functional characterization of muscarinic receptors in rat parotid acini.
Topics: Amylases; Animals; Calcium Radioisotopes; Carbachol; Female; In Vitro Techniques; Inositol Phosphates; N-Methylscopolamine; Parotid Gland; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Rubidium Radioisotopes; Scopolamine Derivatives | 1988 |
Pharmacological differences between muscarinic receptors coupled to phosphoinositide turnover and those coupled to adenylate cyclase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Carbachol; Humans; N-Methylscopolamine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured | 1989 |
Disruption of muscarinic receptor-G protein coupling is a general property of liquid volatile anesthetics.
Topics: Anesthetics; Animals; Brain Stem; Carbachol; GTP-Binding Proteins; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors.
Topics: Animals; Carbachol; Cyclic GMP; In Vitro Techniques; Inositol Phosphates; Mice; N-Methylscopolamine; Neuroblastoma; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1989 |
Mechanism of agonist-induced down-regulation and subsequent recovery of muscarinic acetylcholine receptors in a clonal neuroblastoma x glioma hybrid cell line.
Topics: Animals; Bacitracin; Benzimidazoles; Carbachol; Cell Membrane; Colchicine; Endocytosis; Glioma; Hybrid Cells; Methylamines; Mice; Microtubules; N-Methylscopolamine; Neuroblastoma; Nocodazole; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transglutaminases; Tumor Cells, Cultured | 1989 |
Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells.
Topics: Atropine; Carbachol; Cell Line; Humans; Inositol Phosphates; Kinetics; N-Methylscopolamine; Pancreatic Neoplasms; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured | 1989 |
The interaction of hexamethonium with muscarinic receptor subtypes in vitro.
Topics: Animals; Carbachol; Diamines; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; N-Methylscopolamine; Pirenzepine; Potassium Chloride; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1989 |
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N-Methylscopolamine; Norepinephrine; Phosphatidylinositols; Physostigmine; Potassium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Characteristics of phorbol ester- and agonist-induced down-regulation of astrocyte receptors coupled to inositol phospholipid metabolism.
Topics: Animals; Astrocytes; Calcium; Carbachol; GTP-Binding Proteins; N-Methylscopolamine; Norepinephrine; Phorbol Esters; Phosphatidylinositols; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Guinea Pigs; Ileum; Muscle, Smooth; N-Methylscopolamine; Oxotremorine; Parotid Gland; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine.
Topics: Animals; Atropine; Carbachol; Cyclic GMP; Hydrolysis; Mice; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Mediation of separate responses by high affinity and low affinity agonist-receptor conformations.
Topics: Animals; Benzodiazepinones; Carbachol; Clone Cells; Cyclic AMP; Cyclic GMP; Kinetics; Mice; N-Methylscopolamine; Neuroblastoma; Pirenzepine; Protein Conformation; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, Ion Exchange; Humans; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; N-Methylscopolamine; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1985 |
Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites.
Topics: Benzodiazepinones; Carbachol; Cells, Cultured; Cyclic GMP; N-Methylscopolamine; Neuroblastoma; Pirenzepine; Protein Conformation; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1986 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115): cyclic GMP formation is mediated by a low affinity agonist-receptor conformation and cyclic AMP reduction is mediated by a high affinity agonist-receptor conformation.
Topics: Animals; Benzodiazepinones; Carbachol; Cells, Cultured; Cyclic AMP; Cyclic GMP; N-Methylscopolamine; Neuroblastoma; Pirenzepine; Protein Conformation; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: desensitization by receptor agonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Kinetics; Male; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Virulence Factors, Bordetella | 1987 |
Effect of pH on muscarinic acetylcholine receptors from rat brainstem.
Topics: Animals; Brain Stem; Carbachol; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Male; Mathematics; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Scopolamine Derivatives; Temperature; Time Factors | 1986 |
Release of N-[3H]methylscopolamine from isolated guinea pig atria is controlled by diffusion and rebinding.
Topics: Animals; Carbachol; Diffusion; Female; Guinea Pigs; Heart Atria; Male; Membranes; Myocardium; N-Methylscopolamine; Oxotremorine; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1988 |
Characterization of cholinergic muscarinic receptors in the rabbit iris.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Ileum; Iris; Kinetics; Methacholine Chloride; Methacholine Compounds; Microsomes; N-Methylscopolamine; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Evidence that hyperglycemia increases muscarinic binding in pancreatic islets of the rat.
Topics: Acetylcholine; Animals; Carbachol; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Muscarinic stimulation of submucosal glands in swine trachea.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Exocrine Glands; Isoflurophate; Male; Mucus; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Swine; Trachea | 1988 |
Recognition of muscarinic cholinergic receptors in human SK-N-SH neuroblastoma cells by quaternary and tertiary ligands is dependent upon temperature, cell integrity, and the presence of agonists.
Topics: Atropine; Binding, Competitive; Carbachol; Humans; Kinetics; Ligands; N-Methylscopolamine; Neuroblastoma; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Temperature; Tumor Cells, Cultured | 1988 |
Reconstitution of solubilized atrial cholinergic muscarinic receptors in liposomes.
Topics: Animals; Binding, Competitive; Carbachol; Cattle; Glycine max; Guanylyl Imidodiphosphate; Heart Atria; Kinetics; Liposomes; Myocardium; N-Methylscopolamine; Phosphatidylcholines; Receptors, Muscarinic; Scopolamine Derivatives; Solubility | 1987 |
Muscarinic receptor heterogeneity in rat central nervous system. II. Brain receptors labeled by [3H]oxotremorine-M correspond to heterogeneous M2 receptors with very high affinity for agonists.
Topics: Animals; Binding, Competitive; Brain; Carbachol; Cerebral Cortex; Kinetics; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Characterization of the muscarinic receptor subtype in isolated gastric fundic cells of the rabbit.
Topics: Aminopyrine; Animals; Atropine; Carbachol; Gastric Fundus; Kinetics; Male; N-Methylscopolamine; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Autoradiographic localization of muscarinic cholinergic receptors in visual areas of cat brain: variations in sensitivity of N-[3H]methylscopolamine binding sites to carbachol and pirenzepine.
Topics: Animals; Autoradiography; Brain; Carbachol; Cats; Male; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tritium; Visual Pathways | 1987 |
Features of ligand binding in homogenate and section preparations.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Carbachol; Kinetics; N-Methylscopolamine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
The effect of ionic strength on cardiac muscarinic receptors.
Topics: Animals; Binding, Competitive; Carbachol; In Vitro Techniques; Male; Membranes; Myocardium; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Chloride | 1986 |
Discrimination by N-ethylmaleimide between the chronotropic and inotropic response to muscarinic receptor stimulation in rat atrium.
Topics: Animals; Carbachol; Drug Interactions; Ethylmaleimide; Heart Atria; Male; Myocardial Contraction; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Muscarinic receptor coupling to intracellular calcium release in rat pancreatic acinar carcinoma.
Topics: Animals; Binding, Competitive; Calcium; Carbachol; Carcinoma; N-Methylscopolamine; Oxotremorine; Pancreatic Neoplasms; Proteins; Rats; Rats, Inbred F344; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Irreversible binding of acetylethylcholine mustard to cardiac cholinergic muscarinic receptors.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Membrane; Guanylyl Imidodiphosphate; Heart Rate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Differential effect of temperature on histamine- and carbachol-stimulated inositol phospholipid breakdown in slices of guinea-pig cerebral cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Guinea Pigs; Histamine; In Vitro Techniques; Inositol Phosphates; Male; N-Methylscopolamine; Pyrilamine; Scopolamine Derivatives; Sugar Phosphates; Temperature | 1987 |
Agonist-induced muscarinic acetylcholine receptor down-regulation in intact rat brain cells.
Topics: Animals; Atropine; Brain; Carbachol; Female; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Muscarinic acetylcholine receptors in chick heart: influence of heat and N-ethylmaleimide on receptor conformations and interactions with guanine nucleotide-dependent regulatory proteins.
Topics: Animals; Benzodiazepinones; Carbachol; Chick Embryo; Ethylmaleimide; Heart; Hot Temperature; Molecular Conformation; Myocardium; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
Halothane effects on muscarinic acetylcholine receptor complexes in rat brain.
Topics: Animals; Brain Chemistry; Brain Stem; Carbachol; Cerebral Cortex; Halothane; In Vitro Techniques; Kinetics; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1986 |
Regional heterogeneity of muscarinic acetylcholine receptors from rat brain is retained after detergent solubilization.
Topics: Animals; Brain Chemistry; Brain Stem; Carbachol; Cerebral Cortex; Detergents; Digitonin; Hippocampus; N-Methylscopolamine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Surface-Active Agents | 1985 |
Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function.
Topics: Animals; Atropine; Carbachol; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Receptors, Muscarinic; Scopolamine Derivatives; Temperature | 1985 |
Use of intact rat brain cells as a model to study regulation of muscarinic acetylcholine receptors.
Topics: Animals; Brain; Carbachol; Female; In Vitro Techniques; Kinetics; Male; Models, Biological; N-Methylscopolamine; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.
Topics: Astrocytoma; Atropine; Carbachol; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Guanosine Triphosphate; Humans; Kinetics; N-Methylscopolamine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; In Vitro Techniques; Male; Models, Structural; Myocardium; N-Methylscopolamine; Oxotremorine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1985 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Selective loss with subculturing of the low-affinity agonist site mediating cyclic GMP formation.
Topics: Animals; Binding, Competitive; Bradykinin; Carbachol; Cell Line; Clone Cells; Cyclic GMP; Guanylate Cyclase; Histamine; Kinetics; Mice; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives | 1984 |
Muscarinic cholinergic receptors flow in the sciatic nerve.
Topics: Animals; Autoradiography; Axonal Transport; Carbachol; Ganglia, Spinal; N-Methylscopolamine; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Sciatic Nerve; Scopolamine Derivatives; Synaptic Transmission; Vagus Nerve | 1981 |
3H-methyl scopolamine binding to dispersed pancreatic acini.
Topics: Amylases; Animals; Carbachol; Cell Membrane; Cytoplasmic Granules; Kinetics; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Inbred Strains; Scopolamine Derivatives | 1981 |
Modulation of rat pancreatic amylase secretion and muscarinic receptor populations by chronic bethanechol treatment.
Topics: Amylases; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1983 |
Characterization of muscarinic cholinergic receptors on rat pancreatic acini by N-[3H]methylscopolamine binding. Their relationship with calcium 45 efflux and amylase secretion.
Topics: Amylases; Animals; Binding, Competitive; Calcium; Carbachol; Male; N-Methylscopolamine; Pancreas; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1984 |
Influence of phospholipase C on muscarinic acetylcholine receptor binding in rat brain.
Topics: Animals; Carbachol; Cerebral Cortex; Male; N-Methylscopolamine; Phospholipases; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Scopolamine Derivatives; Type C Phospholipases | 1984 |
Pharmacological evidence for cardiac muscarinic receptor subtypes.
Topics: Acetylcholine; Animals; Arecoline; Atropine; Benzodiazepinones; Binding Sites; Butylscopolammonium Bromide; Carbachol; Female; Guinea Pigs; Heart Rate; Male; Myocardial Contraction; Myocardium; N-Methylscopolamine; Pirenzepine; Quaternary Ammonium Compounds; Receptors, Muscarinic; Scopolamine Derivatives | 1984 |
Binding of agonists and antagonists to muscarinic acetylcholine receptors on intact cultured heart cells.
Topics: Animals; Binding, Competitive; Carbachol; Cells, Cultured; Chick Embryo; Guanylyl Imidodiphosphate; Kinetics; Myocardium; N-Methylscopolamine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Scopolamine Derivatives | 1983 |
Subclasses of muscarinic receptors in isolated gastric mucosal cells: receptor characterization and parietal cell function.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Carbachol; Dogs; Gastric Mucosa; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; N-Methylscopolamine; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1983 |
Muscarinic receptors and responses in intact embryonic chick atrial and ventricular heart cells.
Topics: Animals; Brain; Carbachol; Cells, Cultured; Chick Embryo; Heart; Heart Atria; Heart Ventricles; Myocardium; N-Methylscopolamine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Tissue Distribution; Tissue Extracts | 1984 |
Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells.
Topics: Animals; Carbachol; Clone Cells; Mice; N-Methylscopolamine; Neuroblastoma; Neurons; Receptors, Muscarinic; Scopolamine Derivatives | 1984 |
Distribution of muscarinic cholinergic high and low affinity agonist binding sites: a light microscopic autoradiographic study.
Topics: Animals; Atropine; Autoradiography; Brain; Brain Stem; Carbachol; Kinetics; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Spinal Cord | 1984 |
Differential regulation of muscarinic and nicotinic receptors by cholinergic stimulation in cultured avian retina cells.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Chick Embryo; N-Methylscopolamine; Neurons; Nicotine; Oxotremorine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Retina; Scopolamine Derivatives; Tubocurarine | 1983 |
Short-term disappearance of muscarinic cell surface receptors in carbachol-induced desensitization.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Cerebellum; Glioma; Hybrid Cells; N-Methylscopolamine; Neuroblastoma; Neurons; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1983 |
Agonist regulation of the muscarinic cholinergic receptor in embryonic chick heart.
Topics: Animals; Carbachol; Cell Membrane Permeability; Cells, Cultured; Chick Embryo; Embryo, Mammalian; Embryo, Nonmammalian; Myocardial Contraction; Myocardium; N-Methylscopolamine; Potassium; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors | 1983 |
The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity.
Topics: Animals; Benzodiazepinones; Carbachol; Ciliary Body; Guanylyl Imidodiphosphate; Kinetics; Macaca fascicularis; N-Methylscopolamine; Pilocarpine; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1982 |
Muscarinic receptors in the stomach.
Topics: Animals; Benzodiazepinones; Carbachol; Dogs; Gastric Fundus; Gastric Mucosa; Guanosine Triphosphate; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Piperazines; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Sympathetic Nervous System | 1980 |
A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart.
Topics: Animals; Carbachol; Electric Conductivity; Heart; Isomerism; Kinetics; Light; Muscarine; Myocardium; N-Methylscopolamine; Quaternary Ammonium Compounds; Rana temporaria; Receptors, Muscarinic; Scopolamine Derivatives; Temperature | 1982 |
The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.
Topics: Animals; Carbachol; Cell Membrane; Cells, Cultured; Chick Embryo; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Myocardium; N-Methylscopolamine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1982 |
Agonist-induced changes in the modulation of K+ permeability and beating rate by muscarinic agonists in cultured heart cells.
Topics: Animals; Binding Sites; Carbachol; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Heart Rate; Myocardium; N-Methylscopolamine; Parasympathomimetics; Permeability; Potassium; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1982 |
Muscarinic cholinergic receptors: autoradiographic localization of high and low affinity agonist binding sites.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Carbachol; Kinetics; Male; N-Methylscopolamine; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Tissue Distribution; Tritium | 1980 |
Modulation of agonist binding by guanine nucleotides in CHO cells expressing muscarinic m1-m5 receptors.
Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Guanine Nucleotides; Guanylyl Imidodiphosphate; Humans; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives | 1995 |
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
Topics: Animals; Calcium; Carbachol; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Inositol 1,4,5-Trisphosphate; N-Methylscopolamine; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1995 |
Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor.
Topics: Amino Acid Sequence; Animals; Carbachol; Cell Line; Cell Membrane; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Hydrolysis; Ligands; Molecular Sequence Data; Muscarinic Antagonists; N-Methylscopolamine; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1995 |
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Carbachol; Cell Line; Codon; GTP-Binding Proteins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Parasympatholytics; Piperidines; Proline; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; RNA; Scopolamine Derivatives; Transfection; Tryptophan | 1993 |
Structural and functional changes of exocrine pancreas induced by FK506 in rats.
Topics: Amylases; Analysis of Variance; Animals; Atropine; Body Weight; Calcimycin; Calcium; Carbachol; Cholecystokinin; Colforsin; Cytosol; Dose-Response Relationship, Drug; Feeding Behavior; Kinetics; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Reference Values; Scopolamine; Scopolamine Derivatives; Secretin; Sincalide; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Trypsinogen; Vasoactive Intestinal Peptide | 1993 |
Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Hydrolysis; N-Methylscopolamine; Phosphatidylinositols; Pilocarpine; Receptors, Muscarinic; Scopolamine Derivatives; Stimulation, Chemical; Substrate Specificity; Transfection | 1993 |
Dual effects of chlorobutanol on secretory response and intracellular Ca2+ dynamics in isolated pancreatic acini of the rat.
Topics: Amylases; Animals; Binding, Competitive; Calcium; Carbachol; Chlorobutanol; Cytoplasm; In Vitro Techniques; Male; N-Methylscopolamine; Pancreas; Parasympatholytics; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Scopolamine Derivatives; Signal Transduction; Sincalide; Sodium Fluoride | 1993 |
Agonist-regulated alteration of the affinity of pancreatic muscarinic cholinergic receptors.
Topics: Amylases; Animals; Binding, Competitive; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Pancreas; Parasympathomimetics; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate | 1993 |
Competitive inhibition by procaine of carbachol-induced stimulus-secretion coupling in rat pancreatic acini.
Topics: Amylases; Animals; Binding, Competitive; Calcium; Carbachol; Fluorescent Dyes; Fura-2; Image Processing, Computer-Assisted; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; N-Methylscopolamine; Pancreas; Parasympatholytics; Perfusion; Procaine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Muscarinic; Scopolamine Derivatives; Sincalide | 1993 |
The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Arginine; Carbachol; Cations, Divalent; Cell Line; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Molecular Sequence Data; Muscarinic Agonists; Mutation; N-Methylscopolamine; Phosphatidylinositols; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1995 |
Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.
Topics: Animals; Base Sequence; beta-Adrenergic Receptor Kinases; Carbachol; Cells, Cultured; Chlorocebus aethiops; Cricetinae; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Genes, Dominant; GTP-Binding Proteins; Mesocricetus; Molecular Sequence Data; Mutation; N-Methylscopolamine; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Muscarinic; Scopolamine Derivatives | 1994 |
Clozapine injected into the nucleus accumbens potentiates apomorphine-induced jaw movements.
Topics: Analysis of Variance; Animals; Apomorphine; Carbachol; Clozapine; Drug Interactions; Injections, Intravenous; Jaw; Male; Muscarinic Antagonists; N-Methylscopolamine; Nucleus Accumbens; Parasympatholytics; Prazosin; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Serotonin Antagonists | 1994 |
Clozapine is a potent and selective muscarinic M4 receptor agonist.
Topics: Animals; Carbachol; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Humans; Hydrolysis; Muscarinic Agonists; N-Methylscopolamine; Parasympatholytics; Phosphatidylinositols; Salivation; Scopolamine Derivatives | 1994 |
Functional role in ligand binding and receptor activation of an asparagine residue present in the sixth transmembrane domain of all muscarinic acetylcholine receptors.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Asparagine; Binding, Competitive; Carbachol; Enzyme Activation; GTP-Binding Proteins; In Vitro Techniques; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Binding Sites; Carbachol; Cell Line; Chlorocebus aethiops; GTP-Binding Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; N-Methylscopolamine; Phosphatidylinositols; Piperidines; Protein Structure, Secondary; Rats; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Transfection | 1994 |
Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.
Topics: Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Intestines; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Parasympathomimetics; Peptide Fragments; Protein Precursors; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate | 1994 |
Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C.
Topics: Amino Acid Sequence; Animals; Carbachol; Cell Line; Chlorocebus aethiops; Cytoplasm; Enzyme Activation; GTP-Binding Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Protein Conformation; Protein Structure, Secondary; Rats; Receptors, Muscarinic; Restriction Mapping; Scopolamine Derivatives; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Differential role of the carboxyl-terminal tyrosine in down-regulation and sequestration of the m2 muscarinic acetylcholine receptor.
Topics: Amino Acid Sequence; Animals; beta-Galactosidase; Carbachol; Cell Line; Cell Membrane; Choriocarcinoma; Cyclic AMP; Down-Regulation; Female; Humans; Kinetics; Luciferases; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Pregnancy; Quinuclidinyl Benzilate; Receptors, Adrenergic, beta-2; Receptors, Muscarinic; Scopolamine Derivatives; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured; Tyrosine; Uterine Neoplasms | 1994 |
Interaction of iodinated quinuclidinyl benzilate enantiomers with M3 muscarinic receptors.
Topics: Animals; Carbachol; Inositol 1,4,5-Trisphosphate; Iodine Radioisotopes; Male; N-Methylscopolamine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism | 1994 |
Further evidence for a functional dorsal-ventral division of the rat striatum: GABAergic involvement in oral movements.
Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Benzazepines; Carbachol; Corpus Striatum; Dopamine; Flunitrazepam; gamma-Aminobutyric Acid; Jaw; Male; Muscimol; N-Methylscopolamine; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives | 1993 |
Characterization of muscarinic receptors on guinea pig gallbladder smooth muscle.
Topics: Animals; Autoradiography; Carbachol; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tetrodotoxin | 1993 |
Relationship between muscarinic receptor occupancy and response in rat parotid acinar cells.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; N-Methylscopolamine; Parasympatholytics; Parotid Gland; Propylbenzilylcholine Mustard; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Time Factors; Tritium | 1993 |
Agonist-induced muscarinic cholinergic receptor internalization, recycling and degradation in cultured neuronal cells. Cellular mechanisms and role in desensitization.
Topics: Animals; Carbachol; Cell Membrane; Down-Regulation; GTP-Binding Proteins; Humans; Mice; N-Methylscopolamine; Neurons; Phosphorylation; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Second Messenger Systems; Temperature; Time Factors; Tritium; Tumor Cells, Cultured | 1994 |
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.
Topics: Acetylcholine; Animals; Carbachol; Cell Line; GTP-Binding Proteins; Kinetics; Models, Structural; N-Methylscopolamine; Parasympatholytics; Phosphatidylinositols; Piperidines; Protein Structure, Secondary; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Recombinant Fusion Proteins; Scopolamine Derivatives; Signal Transduction; Transfection; Yohimbine | 1993 |
Studies of muscarinic receptor reserve linked to phosphoinositide hydrolysis in parotid gland and cerebral cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Choline; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kinetics; N-Methylscopolamine; Oxotremorine; Parasympathomimetics; Parotid Gland; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1993 |
Muscarinic M3 receptors mediate total inositol phosphates accumulation in murine HSDM1C1 fibrosarcoma cells.
Topics: Animals; Binding, Competitive; Carbachol; Dioxolanes; Fibrosarcoma; Inositol Phosphates; Mice; Muscarine; Muscarinic Antagonists; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured | 1993 |
Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C.
Topics: Alkaloids; Animals; Carbachol; Furans; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Mitochondria; N-Methylscopolamine; Naphthalenes; Oxotremorine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes; Type C Phospholipases | 1993 |
H3-receptor activation inhibits cholinergic stimulation of acid secretion in isolated rabbit fundic glands.
Topics: Animals; Carbachol; Cholinergic Antagonists; Gastric Acid; Gastric Fundus; Gastric Mucosa; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Methylhistamines; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Rabbits; Ranitidine; Receptors, Histamine H3; Receptors, Muscarinic; Scopolamine Derivatives | 1995 |
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Humans; Inositol Phosphates; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transfection; Tritium | 1995 |
Muscarinic cholinergic receptors in brain and atrial membranes of adult brook trout (Salvelinus fontinalis) measured by radioligand binding techniques.
Topics: Animals; Atropine; Binding, Competitive; Brain Chemistry; Carbachol; Heart Atria; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Trout | 1995 |
Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Binding, Competitive; Carbachol; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immune Sera; Male; Muscarinic Agonists; N-Methylscopolamine; Neuropeptides; Olfactory Bulb; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives; Tritium | 1996 |
Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains.
Topics: 3T3 Cells; Adenylyl Cyclases; Animals; Atropine; beta-Galactosidase; Binding, Competitive; Carbachol; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; GTP-Binding Proteins; Humans; Kinetics; Mice; N-Methylscopolamine; Phosphatidylinositols; Receptors, Muscarinic; Recombinant Fusion Proteins; Scopolamine Derivatives; Signal Transduction; Transfection | 1996 |
Amino acid side chains that define muscarinic receptor/G-protein coupling. Studies of the third intracellular loop.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Arginine; Carbachol; Cloning, Molecular; Conserved Sequence; GTP-Binding Proteins; Isoleucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Protein Structure, Secondary; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Structure-Activity Relationship; Threonine; Transfection; Tyrosine | 1996 |
Identification of a region required for subtype-specific agonist-induced sequestration of the m2 muscarinic acetylcholine receptor.
Topics: Amino Acid Sequence; Carbachol; Cell Line; Colforsin; Humans; Kinetics; Luciferases; Models, Structural; Molecular Sequence Data; Muscarinic Agonists; N-Methylscopolamine; Polymerase Chain Reaction; Protein Structure, Secondary; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Fusion Proteins; Restriction Mapping; Scopolamine Derivatives; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1996 |
Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptors but not m2 receptor mRNA in a human lung cell line.
Topics: Binding, Competitive; Blotting, Northern; Carbachol; Cell Line; Cyclic AMP; Dactinomycin; Down-Regulation; Fibroblasts; Gene Expression Regulation; Humans; Lung; Muscarinic Agonists; N-Methylscopolamine; Receptor, Muscarinic M2; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Transcription, Genetic | 1995 |
Human muscarinic cholinergic receptor Hm1 internalizes via clathrin-coated vesicles.
Topics: Amino Acid Sequence; Base Sequence; Carbachol; Cell Line; Clathrin; Coated Pits, Cell-Membrane; DNA Primers; Endocytosis; Humans; Immunohistochemistry; Kinetics; Molecular Sequence Data; N-Methylscopolamine; Polymerase Chain Reaction; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Sequence Tagged Sites; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.
Topics: Adenylyl Cyclase Inhibitors; Arachidonic Acid; Base Sequence; Blotting, Southern; Calcium; Carbachol; Cell Adhesion; Cell Division; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; DNA Primers; Egtazic Acid; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Melanoma; Molecular Sequence Data; N-Methylscopolamine; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Receptor, Muscarinic M5; Receptors, Muscarinic; Scopolamine Derivatives; Signal Transduction; Time Factors; Tumor Cells, Cultured | 1996 |
Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Cell Line; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Lithium; N-Methylscopolamine; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Signal Transduction; Terpenes; Thapsigargin; Transfection; Tumor Cells, Cultured | 1996 |
Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-X-X-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Carbachol; Cell Membrane; CHO Cells; Conserved Sequence; Cricetinae; DNA Primers; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Oxotremorine; Protein Structure, Secondary; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Second Messenger Systems; Transfection | 1996 |
SK & F 96365 inhibits carbachol-induced phosphoinositide turnover in human neuroblastoma SH-SY5Y and rat cerebellar granule cells.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Carbachol; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Humans; Imidazoles; N-Methylscopolamine; Neuroblastoma; Phosphatidylinositols; Radioligand Assay; Rats; Scopolamine Derivatives; Tritium; Tumor Cells, Cultured | 1996 |
Evidence for contribution of effector organ cellular responses to the biphasic dynamics of heat acclimation.
Topics: Acclimatization; Animals; Body Temperature Regulation; Calcium; Carbachol; Cell Physiological Phenomena; Cells; Hot Temperature; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Rubidium Radioisotopes; Scopolamine Derivatives; Signal Transduction; Submandibular Gland; Sweating | 1996 |
Inhibitory effect of caffeine on the response to carbachol in rat pancreatic acini.
Topics: Amylases; Animals; Caffeine; Calcium; Carbachol; Dose-Response Relationship, Drug; Male; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pancreas; Rats; Rats, Wistar; Scopolamine Derivatives | 1996 |
Spinal muscarinic cholinergic and nitric oxide systems in cardiovascular regulation.
Topics: Animals; Arginine; Blood Pressure; Carbachol; Cardiovascular Physiological Phenomena; Drug Interactions; Enzyme Inhibitors; Heart Rate; Injections, Spinal; Male; N-Methylscopolamine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Spinal Cord; Stimulation, Chemical; Tritium | 1996 |
Muscarinic receptors and insulin concentration in the rat pancreas after chronic alcohol intake and cholinergic stimulation.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Ethanol; Insulin; Male; N-Methylscopolamine; Pancreas; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives | 1996 |
Role of two highly conserved tyrosine residues in the m1 muscarinic receptor second transmembrane domain in ligand binding and receptor function.
Topics: Animals; Binding Sites; Carbachol; CHO Cells; Conserved Sequence; Cricetinae; Hydrolysis; Ligands; Molecular Structure; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Radioligand Assay; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Scopolamine Derivatives; Tyrosine | 1996 |
Functional role of the third cytoplasmic loop in muscarinic receptor dimerization.
Topics: Animals; Carbachol; COS Cells; Hydrolysis; N-Methylscopolamine; Phosphatidylinositols; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Fusion Proteins; Scopolamine Derivatives; Structure-Activity Relationship; Yohimbine | 1996 |
Cardiac muscarinic receptors. Relationship between the G protein and multiple states of affinity.
Topics: Animals; Carbachol; Cell Membrane; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanylyl Imidodiphosphate; Mesocricetus; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1997 |
Impairment of muscarinic stimulation of adenylyl cyclase by heparin in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Carbachol; Colforsin; Corpus Striatum; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heparin; In Vitro Techniques; Kinetics; Male; Muscarinic Agonists; N-Methylscopolamine; Olfactory Bulb; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives | 1997 |
Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2.
Topics: Animals; beta-Adrenergic Receptor Kinases; Binding Sites; Carbachol; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Endocytosis; Humans; Models, Biological; N-Methylscopolamine; Protein Conformation; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins | 1998 |
Arecoline desensitizes carbachol-stimulated phosphatidylinositol breakdown in rat brain cortices.
Topics: Animals; Arecoline; Carbachol; Cerebral Cortex; Female; GTP-Binding Proteins; Inositol Phosphates; Muscarinic Agonists; N-Methylscopolamine; Organ Culture Techniques; Parasympatholytics; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Tritium | 1998 |
On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Phosphatidylinositols; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors | 1998 |
Lithocholyltaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atropine; Carbachol; Chief Cells, Gastric; Cholagogues and Choleretics; Cholecystokinin; Guinea Pigs; Male; N-Methylscopolamine; Parasympatholytics; Pepsinogens; Receptors, Cholinergic; Sincalide; Taurolithocholic Acid | 1998 |
Carbachol-induced desensitization of PLC-beta pathway in rat myometrium: downregulation of Gqalpha/G11alpha.
Topics: Aluminum Compounds; Animals; Atropine; Carbachol; Enzyme Inhibitors; Female; Fluorides; GTP-Binding Proteins; In Vitro Techniques; Indoles; Inositol; Inositol Phosphates; Isoenzymes; Kinetics; Membrane Potentials; Myometrium; N-Methylscopolamine; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phospholipase C beta; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1998 |
Heterologous regulation of muscarinic and beta-adrenergic receptors in rat cardiomyocytes in culture.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Binding, Competitive; Bucladesine; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Inhibitors; Female; Indoles; Isoproterenol; Isoquinolines; Kinetics; Male; Maleimides; Muscarinic Agonists; Myocardium; N-Methylscopolamine; Propanolamines; Protein Kinase C; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Sulfonamides; Thionucleotides; Tritium | 1998 |
Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effects.
Topics: Animals; Atropine; Autoantibodies; Binding Sites; Carbachol; Cardiomyopathy, Dilated; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Down-Regulation; Heart Rate; Humans; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptors, Muscarinic; Time Factors | 1999 |
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; CHO Cells; Citrulline; Cricetinae; Humans; Kinetics; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Thiadiazoles; Transfection; Tritium | 1999 |
Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Carbachol; Cell Membrane; Conserved Sequence; COS Cells; Cysteine; Disulfides; GTP-Binding Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Protein Structure, Secondary; Radioligand Assay; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Transfection; Tritium | 1999 |
Muscarinic cholinergic receptors activate both inhibitory and stimulatory growth mechanisms in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; Genes, src; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Methylscopolamine; Phosphorylation; Receptor, Muscarinic M3; Receptors, Muscarinic; Retinoblastoma Protein | 1999 |
Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Carbachol; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Ligands; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic | 1999 |
Mechanisms underlying the inhibitory effect of propofol on the contraction of canine airway smooth muscle.
Topics: Anesthetics, Intravenous; Animals; Calcium; Carbachol; Dogs; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; N-Methylscopolamine; Propofol; Trachea | 1999 |
Depolarization affects the binding properties of muscarinic acetylcholine receptors and their interaction with proteins of the exocytic apparatus.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain; Calcium; Carbachol; CHO Cells; Cricetinae; Exocytosis; Humans; Membrane Potentials; Membrane Proteins; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Protein Binding; Qa-SNARE Proteins; Rats; Receptors, Muscarinic; Synaptosomes; Transfection | 1999 |
A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling.
Topics: Amino Acid Sequence; Animals; Brain; Calcium; Calcium Channels; Carbachol; Cattle; Cells, Cultured; CHO Cells; Clonidine; Cricetinae; Cytoplasm; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; N-Methylscopolamine; Neurons; Oxotremorine; Peptide Fragments; Receptor, Muscarinic M4; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Receptors, Somatostatin; Signal Transduction; Spinal Cord; Superior Cervical Ganglion; Transfection | 1999 |
Internalization and down-regulation of muscarinic acetylcholine receptors in cerebellar granule cells of tenascin-gene deficient mice.
Topics: Animals; Carbachol; Cell Membrane; Cerebellum; Cholinergic Agonists; Down-Regulation; Mice; Mice, Knockout; N-Methylscopolamine; Paclitaxel; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tenascin; Tritium | 2000 |
Effects of ethanol on phosphoinositide hydrolysis and muscarinic acetylcholine receptor number in SH-SY5Y cells.
Topics: Binding Sites; Carbachol; Dose-Response Relationship, Drug; Ethanol; Humans; Hydrolysis; N-Methylscopolamine; Neuroblastoma; Phosphatidylinositols; Receptors, Muscarinic; Tumor Cells, Cultured | 2000 |
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Topics: Acetylcholine; Animals; Carbachol; Cell Membrane; CHO Cells; Cholinergic Agents; Cricetinae; Cyclic AMP; Elapid Venoms; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M1; Receptors, Muscarinic; Tritium | 2000 |
Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells.
Topics: Carbachol; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Isoenzymes; Membrane Proteins; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Prostaglandin-Endoperoxide Synthases; Receptor, Muscarinic M3; Receptors, Muscarinic; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Up-Regulation | 2000 |
Dual effects of muscarinic M(2) acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time, receptor density and receptor agonists.
Topics: Animals; Binding Sites; Carbachol; CHO Cells; Cholera Toxin; Cholinergic Agonists; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Oxyphenonium; Receptor, Muscarinic M2; Receptors, Muscarinic; Time Factors; Transfection; Tritium | 2001 |
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.
Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Interaction of edrophonium with muscarinic acetylcholine M2 and M3 receptors.
Topics: Animals; Bronchoconstriction; Carbachol; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Edrophonium; Guinea Pigs; Heart Rate; Male; N-Methylscopolamine; Potassium Channels; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic | 2001 |
A new enzymic method for the isolation and culture of human bladder body smooth muscle cells.
Topics: Calcium; Carbachol; Cell Separation; Cells, Cultured; Cholinergic Agonists; Collagenases; Cytological Techniques; Humans; Intracellular Membranes; Male; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Trypsin; Urinary Bladder | 2002 |
Muscarinic cholinergic receptor blockade impairs free fatty acid mobilization during fasting in pigeons (Columba livia).
Topics: Animals; Blood Glucose; Carbachol; Cholinergic Agonists; Columbidae; Fasting; Fatty Acids, Nonesterified; Injections, Intraventricular; Lipolysis; Male; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Receptors, Muscarinic; Scopolamine | 2002 |
Effects of N-ethylmaleimide on conformational equilibria in purified cardiac muscarinic receptors.
Topics: Animals; Blotting, Western; Carbachol; Cell Line; Enzyme Inhibitors; Ethylmaleimide; Humans; Insecta; Kinetics; Ligands; Models, Chemical; Muscarinic Agonists; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Precipitin Tests; Protein Binding; Protein Conformation; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Sulfhydryl Reagents; Swine; Time Factors | 2002 |
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cells, Cultured; Humans; N-Methylscopolamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Tritium | 2003 |
Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pilocarpine; Pyridines; Receptor, Muscarinic M5; Thiadiazoles | 2005 |
A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state.
Topics: Acetylcholine; Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Protein alpha Subunit, Gi2; N-Methylscopolamine; Peptide Fragments; Protein Prenylation; Quinuclidinyl Benzilate; Receptor, Muscarinic M2 | 2006 |
Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Thiadiazoles | 2006 |
M1 muscarinic receptors contribute to, whereas M4 receptors inhibit, dopamine D1 receptor-induced [3H]-cyclic AMP accumulation in rat striatal slices.
Topics: Alkaloids; Animals; Benzazepines; Carbachol; Cholinergic Agonists; Corpus Striatum; Cyclic AMP; Dopamine Agonists; Furans; Male; Muscarinic Antagonists; N-Methylscopolamine; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Radioligand Assay; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Dopamine D1 | 2006 |
Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction.
Topics: Animals; Benzilates; Binding, Competitive; Calcium; Carbachol; Cell Line; Cells, Cultured; CHO Cells; Cholinergic Antagonists; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electric Stimulation; Epithelial Cells; Humans; Molecular Structure; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Potassium Chloride; Receptors, Muscarinic; Urinary Bladder | 2006 |
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Benzofurans; Binding, Competitive; Carbachol; CHO Cells; Cholinergic Agonists; Cresols; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mandelic Acids; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Phenylpropanolamine; Pyrrolidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Muscarinic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Transfection; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2007 |
Migrastatin acts as a muscarinic acetylcholine receptor antagonist.
Topics: Animals; Calcium; Carbachol; Cell Line, Tumor; Cells, Cultured; Cyclic AMP; Drinking; Female; Humans; Lactones; Macrolides; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Piperidones; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder | 2006 |
Opposing effects on muscarinic acetylcholine receptors in the piriform cortex of odor-trained rats.
Topics: Animals; Binding, Competitive; Carbachol; Cholinergic Agonists; Discrimination Learning; Electrophysiology; Male; N-Methylscopolamine; Neurons; Odorants; Olfactory Pathways; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 2007 |
Cytokine modulation of muscarinic receptors in the murine intestine.
Topics: Animals; Carbachol; Interferon gamma Receptor; Interferon-gamma; Jejunum; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; N-Methylscopolamine; Receptors, Interferon; Receptors, Muscarinic; Receptors, Transforming Growth Factor beta; STAT6 Transcription Factor; Transforming Growth Factor beta; Trichinella spiralis; Trichinellosis | 2007 |
Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; Cricetulus; Cysteine; Humans; Hydrolysis; Mutagenesis, Site-Directed; N-Methylscopolamine; Phosphatidylinositols; Protein Structure, Tertiary; Receptor, Muscarinic M1; Transfection | 2008 |
Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
Topics: Allosteric Site; Animals; Binding, Competitive; Carbachol; Cells, Cultured; Cricetinae; Cricetulus; Female; Humans; Inositol Phosphates; Ligands; Muscarinic Agonists; N-Methylscopolamine; Ovary; Protein Binding; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Thiadiazoles; Time Factors; Transfection | 2007 |
Assessment of muscarinic receptor subtypes in human and rat lower urinary tract by tissue segment binding assay.
Topics: Aged; Animals; Carbachol; Cell Membrane; Female; Humans; In Vitro Techniques; Male; Middle Aged; Mucous Membrane; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Prostate; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Urinary Bladder | 2008 |
The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.
Topics: Alcuronium; Allosteric Regulation; Animals; Atropine; Carbachol; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Gallamine Triethiodide; Ligands; Models, Biological; N-Methylscopolamine; Radioligand Assay; Receptor, Muscarinic M2; Tritium | 2008 |
Effects of chlorpyrifos oxon on M2 muscarinic receptor internalization in different cell types.
Topics: Animals; Carbachol; Chlorpyrifos; CHO Cells; Cricetinae; Cricetulus; Humans; Immunohistochemistry; Muscarinic Agonists; N-Methylscopolamine; Parasympatholytics; Phosphorylation; Rats; Receptor, Muscarinic M2; Species Specificity | 2008 |
Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways.
Topics: Acetylcholine; Animals; beta-Cyclodextrins; Carbachol; Cell Membrane; CHO Cells; Cholesterol; Cricetinae; Cricetulus; GTP-Binding Proteins; Humans; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M2; Second Messenger Systems | 2009 |
Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding.
Topics: Animals; Atropine; Binding Sites; Carbachol; Cell Line, Transformed; Cricetinae; Drug Interactions; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Muscarinic Agonists; N-Methylscopolamine; Phosphatidylinositols; Pilocarpine; Pyridines; Quinuclidinyl Benzilate; Receptor, Muscarinic M3; Thiadiazoles; Time Factors; Transfection | 2009 |
Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Atropine; Blotting, Western; Calcium; Carbachol; Cell Line, Tumor; Elapid Venoms; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Inositol Phosphates; Kinetics; Mice; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Peptides, Cyclic; Pirenzepine; Protein Kinase Inhibitors; Quinuclidinyl Benzilate; Receptor, Muscarinic M1; Receptors, Cell Surface | 2011 |
Subtype differences in pre-coupling of muscarinic acetylcholine receptors.
Topics: Animals; Binding, Competitive; Carbachol; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Mutation; N-Methylscopolamine; Receptors, Muscarinic | 2011 |
Regional quantification of muscarinic acetylcholine receptors and β-adrenoceptors in human airways.
Topics: Aged; Carbachol; Female; Humans; In Vitro Techniques; Isoproterenol; Ligands; Lung; Male; Middle Aged; Muscle Contraction; N-Methylscopolamine; Propanolamines; Radioligand Assay; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Muscarinic | 2012 |
Structure-Based Design and Discovery of New M
Topics: Acetylcholine; Animals; Arrestin; Benzofurans; Carbachol; CHO Cells; Cricetulus; Drug Design; HEK293 Cells; Humans; Isoxazoles; Ligands; Molecular Docking Simulation; Muscarinic Agonists; N-Methylscopolamine; Quaternary Ammonium Compounds; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Nicotinic; Tritium | 2017 |