carbachol has been researched along with guanosine triphosphate in 169 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (43.79) | 18.7374 |
| 1990's | 75 (44.38) | 18.2507 |
| 2000's | 18 (10.65) | 29.6817 |
| 2010's | 2 (1.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Craven, PA; DeRubertis, FR | 1 |
| Richelson, E | 1 |
| Kury, PG; McConnell, M | 1 |
| Izumi, H; Ozawa, H | 1 |
| Biondi, C; Martini, M; Perri, V; Tomasi, V; Trevisani, A | 1 |
| Lefkowitz, RJ; Limbird, LE | 1 |
| Berrie, CP; Birdsall, NJ; Burgen, AS; Hulme, EC | 1 |
| Sulakhe, PV; Wei, JW | 3 |
| Blume, A; Boone, G; Lichtshtein, D | 1 |
| Aktories, K; Jakobs, KH; Schultz, G | 2 |
| Israel, M; Lesbats, B; Manaranche, R; Marsal, J; Mastour-Frachon, P; Meunier, FM | 1 |
| Olianas, MC; Onali, P | 1 |
| Higashijima, T; Mukai, H; Munekata, E | 1 |
| Haga, T; Shiozaki, K | 1 |
| Bangert, M; Beyer, T; Niroomand, F; Rauch, B | 1 |
| Brown, AM; Okabe, K; Yatani, A | 1 |
| Gollasch, M; Hescheler, J; Offermanns, S; Rosenthal, W; Schmidt, A; Schultz, G; Spicher, K | 1 |
| Osborne, NN | 1 |
| Ammälä, C; Berggren, PO; Bokvist, K; Juntti-Berggren, L; Kindmark, H; Larsson, O; Rorsman, P | 1 |
| Quist, E | 1 |
| Avissar, S; Murphy, DL; Schreiber, G | 1 |
| Hisayama, T; Kiuchi, Y; Kumagai, N; Takayanagi, I | 1 |
| Cohen-Armon, M; Sokolovsky, M | 1 |
| Luthin, GR; Matesic, DF | 1 |
| Golly, F; Larocca, JN; Ledeen, RW | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Evans, T; Ho, YK; Okabe, K; Yatani, A | 1 |
| Avissar, S; Schreiber, G | 1 |
| Li, PP; Sibony, D; Warsh, JJ | 1 |
| Hung, WC; Wei, JW | 1 |
| Bizzarri, C; Corda, D; D'Orazio, MC; Di Girolamo, M | 1 |
| Brown, AM; Yatani, A | 1 |
| Claro, E; Fain, JN; Wallace, MA | 1 |
| Carter, HR; Fain, JN; Wallace, MA | 1 |
| Danilenko, MP; Panchenko, MP; Tkachuk, VA; Yesirev, OV | 1 |
| Kishi, M; Kuriyama, K; Ma, FH; Ohkuma, S | 1 |
| Ehlert, FJ; Rathbun, BE | 1 |
| Gardner, JD; Jensen, RT; McArthur, KE; O'Dorisio, MS; Wood, CL; Zhou, ZC | 1 |
| Goldberg, ND; Graeff, RM; Walseth, TF | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Sekura, RD; Yatani, A | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Hamm, H; Mazzoni, MR; Yatani, A | 1 |
| Kolb, HA; Somogyi, R | 2 |
| Brown, AM; Kirsch, GE | 1 |
| Gierschik, P; Hilf, G; Jakobs, KH | 1 |
| Burke, DN; Fleming, N; Sliwinski-Lis, E | 1 |
| Nahorski, SR; Wojcikiewicz, RJ | 1 |
| Bolton, TB; Komori, S | 1 |
| Claro, E; Garcia, A; Picatoste, F | 1 |
| Dereski, MO; Diglio, C; Giacomelli, F; Grammas, P; Wiener, J | 1 |
| Claro, E; Fain, JN; Lee, HM; Wallace, MA | 1 |
| Casebolt, TL; Johnson, GV; Jope, RS | 1 |
| Ashkenazi, A; Capon, DJ; Peralta, EG; Peterson, GL; Ramachandran, J; Schimerlik, MI; Winslow, JW | 1 |
| Brown, JH; Goldstein, D; Jones, LG | 1 |
| Costa, E; Fadda, E; Nicoletti, F; Wroblewski, JT | 1 |
| Ek, B; Nahorski, S | 1 |
| Chiu, AS; Li, PP; Warsh, JJ | 1 |
| Duman, RS; Enna, SJ; Giachetti, A; Giraldo, E; Krogsgaard-Larsen, P; Micheletti, R; Zorn, SH | 1 |
| Brunton, LL; Buxton, IL | 1 |
| Jagadeesh, G; Phan, NT; Sulakhe, PV | 1 |
| Merritt, JE; Putney, JW; Rubin, RP; Taylor, CW | 2 |
| Narayanan, N; Tucker, L | 1 |
| Blachier, F; Malaisse, WJ | 1 |
| Haga, K; Haga, T; Ichiyama, A; Katada, T; Kurose, H; Ui, M | 1 |
| Galper, JB; Hellmich, MR; Liang, BT; Neer, EJ | 1 |
| Chang, PP; Holmes, RK; Moss, J; Twiddy, EM | 1 |
| Gierschik, P; Luetje, CW; Milligan, G; Nathanson, NM; Spiegel, A; Unson, C | 1 |
| Kahler, KR; Schimerlik, MI; Tota, MR | 1 |
| Banfic, H; Eckhardt, L; Schnefel, S; Schultz, G; Schulz, I | 1 |
| Anthony, BL; Aronstam, RS; Dennison, RL; Narayanan, TK | 1 |
| Bolton, TB; Lim, SP | 1 |
| Fujii, AM; Homcy, CJ; Lee, DL; Longabaugh, JP; Schwarz, KR; Vatner, DE; Vatner, SF | 1 |
| Hokins, LE; MacDonald, MJ; Mertz, RJ; Rana, RS; Sekar, MC | 1 |
| Avissar, S; Belmaker, RH; Danon, A; Schreiber, G | 1 |
| Berstein, G; Haga, K; Haga, T; Ichiyama, A | 1 |
| Ebinger, G; Vanderheyden, P; Vauquelin, G | 2 |
| Christian, AL; Schäfer, R; Schulz, I | 1 |
| Brown, JH; Orellana, S; Solski, PA | 1 |
| Aguilar, JS; De Robertis, E; Fonseca, MI | 1 |
| Kanarek, L; Vanderheyden, P; Vauquelin, G | 1 |
| De Backer, JP; Ebinger, G; Vanderheyden, P; Vauquelin, G | 1 |
| Galper, JB; Liang, BT | 1 |
| Bruni, P; Hewlett, EL; Moss, J | 1 |
| Ravikumar, BV; Sastry, PS | 1 |
| Harden, TK; Petch, LA; Traynelis, SF; Waldo, GL | 1 |
| Ehlert, FJ | 1 |
| Engel, B; Halvorsen, SW; Hunter, DD; Nathanson, NM | 1 |
| Aronstam, RS; Greenbaum, LM | 1 |
| Baron, B; Kloog, Y | 1 |
| Halvorsen, SW; Nathanson, NM | 1 |
| Dowdall, MJ; Golds, PR; Strange, PG | 1 |
| Hammer, R | 1 |
| Dziekan, LC; Galper, JB; O'Hara, DS; Smith, TW | 1 |
| Higuchi, H; Matsumoto, K; Takeyasu, K; Uchida, S; Yoshida, H | 1 |
| Creacy, S; Kellogg, J; Larner, J; Oron, Y | 1 |
| Andrade, R | 1 |
| Yatani, A | 1 |
| Bakhramov, A | 1 |
| Yanai, J; Zamir, I | 1 |
| Sharp, GW; Tang, SH; Yaney, GC | 1 |
| Itagaki, M; Komori, S; Ohashi, H; Syuto, B; Unno, T | 1 |
| Ferrari-DiLeo, G; Flynn, DD; Mash, DC | 1 |
| Depoortere, I; Peeters, TL | 1 |
| Gilbert, JC; Mubagwa, K; Pappano, AJ | 1 |
| Bali, JP; Cuq, P; Magous, R | 1 |
| Haga, T; Kameyama, K; Kato, H; Kato, M; Kikkawa, U; Nakamura, F; Nukada, T; Takenawa, T | 1 |
| Emala, CW; Hirshman, CA; Jacoby, DB; Levine, MA; Proud, D; Yang, J | 1 |
| Hurley, TW; Ryan, MP; Shoemaker, DD | 1 |
| Jakobs, KH; Lenz, W; Sell, A; Van Koppen, CJ | 1 |
| Horikawa, T; Nomura, Y; Okada, F; Tokumitsu, Y | 1 |
| Johnson, GL; Russell, M; Winitz, S | 1 |
| Bombien, E; Homann, D; Jakobs, KH; Offermanns, S; Sandmann, J; Schultz, G; Spicher, K; Wieland, T | 1 |
| Iino, T; Katsura, M; Kuriyama, K | 1 |
| Eberle-Wang, K; Friedman, E; Simansky, KJ; Wang, HY | 1 |
| Jope, RS; Powers, R; Song, L | 1 |
| Bangert, M; Niroomand, F; Philipps, C; Rauch, B | 1 |
| Dwyer, L; Gardner, A; Johnson, GL; Qian, NX; Russell, M; Winitz, S | 1 |
| Barnett, JV; Galper, JB; Taniuchi, M; Yang, MB | 1 |
| Browne, JP; Eccleston, JF; Gong, MC; Hall, A; Iizuka, K; Kobayashi, S; Nixon, G; Somlyo, AP; Somlyo, AV; Sugai, M | 1 |
| Goodwin, LE; Johnson, LJ; Martinez, JR; Seagrave, J | 1 |
| Bian, K; Bukoski, RD; Garfield, RE; Izumi, H | 1 |
| Cheng, E; Cline, RT; Fraser, CM; Geoghagen, NS; Lee, NH | 1 |
| Kübler, W; Mura, RA; Niroomand, F; Piacentini, L; Rauch, B; Zeifang, F | 1 |
| Chen, QH; Metz, SA; Rabaglia, ME; Vadakekalam, J | 1 |
| Rinken, A | 1 |
| Aktories, K; Just, I; Otto, B; Pfitzer, G; Steusloff, A | 1 |
| Bolton, TB; Zholos, AV | 1 |
| Aragay, AM; Brown, JH; Collins, LR; Goldstein, D; Kennedy, ED; Moskowitz, SA; Post, GR | 1 |
| Awad, AB; Fink, CS; Horvath, PJ; Ntanios, FY | 1 |
| Burford, NT; Lameh, J; Sadée, W; Shockley, MS | 1 |
| Seidler, FJ; Slotkin, TA; Zeiders, JL | 1 |
| DeMuro, R; Duffey, ME; Izu, L; Li, M | 1 |
| Felder, CC; Rojas, E; Singer-Lahat, D | 1 |
| Clancy, J; Emala, CW; Hirshman, CA; Schears, G | 1 |
| Koistinaho, J; Kurkinen, KM; Laitinen, JT | 1 |
| Bas, N; García, A; Oliva, AM | 1 |
| Guttmann, RP; Johnson, GV; Lesort, M; Zhang, J | 1 |
| Bolton, TB; Pucovský, V; Zholos, AV | 1 |
| Dobashi, K; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Lannigan, DA; Macara, IG; Tatsis, N | 1 |
| Asmus, M; Bayer, S; Fliegert, F; Jakobs, KH; Joost, HG; Koling, S; Massmann, S; Schilf, C; Schmidt, M; Schürmann, A; Subauste, MC; Voss, M | 1 |
| Coronas, V; Jourdan, F; Krantic, S; Moyse, E | 1 |
| Emala, CW; Hirshman, CA; Liu, F | 1 |
| Cario-Toumaniantz, C; Chardin, P; Loirand, G; Pacaud, P | 1 |
| Furukawa, KI; Motomura, S; Seya, K | 1 |
| Dremier, S; Dumont, JE; Roger, PP; Van Keymeulen, A | 1 |
| Balligand, JL; Dessy, C; Feron, O; Kelly, RA | 1 |
| Akahane, S; Anabuki, J; Hayakawa, K; Hori, M; Karaki, H; Ozaki, H | 1 |
| Culp, DJ; Latchney, LR; Luo, W | 1 |
| Boyett, MR; Shui, Z; Yamanushi, TT | 1 |
| Bergson, C; Koh, PO; Lezcano, N; Lidow, MS; Roberts, A; Zhang, L | 1 |
| Greene, AK; Popova, JS; Rasenick, MM; Wang, J | 1 |
| Eschenhagen, T; Hirt, S; Mittmann, C; Nürnberg, B; Pinkepank, G; Stamatelopoulou, S; Wieland, T | 1 |
| Bolton, TB; Gordienko, DV; Tsvilovskyy, VV; Tsytsyura, YD; Zholos, AV | 1 |
| Bernal, J; Crespo, P; De Abajo, R; Garcia-Ranea, JA; Santisteban, P; Valencia, A; Vargiu, P | 1 |
| Fujita, A; Hata, F; Hirayama, N; Kitayama, M; Kushida, M; Takeuchi, T | 1 |
| Delaney, D; Moreland, RS; Stanton, MC; Zderic, SA | 1 |
| Iseki, E; Shiozaki, K | 1 |
| Azuma, YT; Hata, F; Nakajima, H; Takeuchi, T | 1 |
| Brading, AF; Tugba Durlu-Kandilci, N | 1 |
| Go, L; Mitchell, J | 1 |
| Chen, CY; Chen, X; Evans, E; Hamm-Alvarez, SF; Jerdeva, G; Okamoto, CT; Zhang, W | 1 |
| Dolezal, V; Jakubík, J; Machová, E; Michal, P | 1 |
| Kitazawa, T; Komori, S; Matsuyama, H; Suguro, M; Tanahashi, Y; Unno, T; Yamada, M | 1 |
| Hori, M; Kishi, H; Kobayashi, S; Mori, D; Murata, T; Ohama, T; Ozaki, H | 1 |
1 review(s) available for carbachol and guanosine triphosphate
| Article | Year |
|---|---|
Importance and prospects for design of selective muscarinic agonists.
Topics: Acetylcholine; Animals; Brain; Carbachol; Drug Design; Guanosine Triphosphate; Humans; Muscarinic Agonists; Protein Binding; Pyridines; Receptor, Muscarinic M1; Thiadiazoles | 2008 |
168 other study(ies) available for carbachol and guanosine triphosphate
| Article | Year |
|---|---|
Properties of the guanylate cyclase-guanosine 3':5'-monophosphate system of rat renal cortex. Activation of guanylate cyclase and calcium-independent modulation of tissue guanosine 3':5'-monophosphate by sodium azide.
Topics: Animals; Azides; Calcium; Carbachol; Cyclic GMP; Enzyme Activation; Fluorides; Guanosine Triphosphate; Guanylate Cyclase; Kidney Cortex; Kinetics; Magnesium; Male; Manganese; Rats; Tetracaine | 1976 |
Antipsychotics block muscarinic acetylcholine receptor-mediated cyclic GMP formation in cultured mouse neuroblastoma cells.
Topics: Antipsychotic Agents; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Guanosine Triphosphate; Kinetics; Neuroblastoma; Phenothiazines; Receptors, Cholinergic; Receptors, Muscarinic | 1977 |
Regulation of Membrane Flexibility in Human Erythrocytes.
Topics: Benzenesulfonates; Carbachol; Cell Membrane; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Epinephrine; Erythrocytes; Fatty Acids; Guanosine Triphosphate; Humans; Lipids; Magnesium; Prostaglandins E; Proteins; Spin Labels; Stilbenes; Thiocyanates | 1975 |
Effects of various agents on synaptosomal adenylate cyclase activity in the absence and presence of the boiled supernatant.
Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Carbachol; Cerebral Cortex; Chloromercuribenzoates; Coenzyme A; Cyclic AMP; Cysteine; Cytosol; Egtazic Acid; Glutathione; Guanosine Triphosphate; Male; Molecular Weight; Rats; Synaptosomes | 1975 |
Modulation of cyclic AMP levels in the bovine superior cervical ganglion by prostaglandin E1 and dopamine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Carbachol; Cattle; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Ganglia, Autonomic; Guanosine Triphosphate; In Vitro Techniques; Indomethacin; Norepinephrine; Phenothiazines; Phentolamine; Prostaglandins E; Prostaglandins F; Synaptosomes | 1977 |
Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Carbachol; Cats; Dogs; Female; Guanosine Triphosphate; Guanylate Cyclase; Guinea Pigs; Humans; Kinetics; Manganese; Methacholine Compounds; Myocardium; Parasympathomimetics; Phosphatidylserines; Rats; Subcellular Fractions | 1975 |
Guanine nucleotides modulate muscarinic receptor binding in the heart.
Topics: Animals; Carbachol; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Myocardium; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Ribonucleotides; Scopolamine Derivatives | 1979 |
Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides.
Topics: Animals; Atropine; Carbachol; Drug Interactions; Guanine Nucleotides; Guanosine Triphosphate; Heart; In Vitro Techniques; Parasympatholytics; Parasympathomimetics; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1979 |
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atropine; Carbachol; Cations, Monovalent; Cell Line; Decamethonium Compounds; Glioma; Guanosine Triphosphate; Hexamethonium Compounds; Hybrid Cells; Mice; Neuroblastoma; Nucleotides; Prostaglandins E; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Sodium | 1979 |
GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Carbachol; Guanine Nucleotides; Guanosine Triphosphate; In Vitro Techniques; Myocardium; Oxotremorine; Parasympathetic Nervous System; Parasympathomimetics; Rabbits; Time Factors | 1979 |
Related changes in amounts of ACh and ATP in resting and active Torpedo nerve electroplaque synapses.
Topics: Acetates; Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Calcium; Carbachol; Choline; Cytosine Nucleotides; Electric Organ; Electric Stimulation; Female; Fishes; Guanosine Triphosphate; Oscillometry; Synapses | 1977 |
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Bacterial Toxins; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Neurotransmitter Agents; Olfactory Bulb; Parasympathomimetics; Rats | 1992 |
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Carbachol; Cattle; Cell Line; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Insecta; Kinetics; Macromolecular Substances; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Receptors, Adrenergic, beta; Receptors, Muscarinic; Structure-Activity Relationship; Substance P; Transfection; Turkeys | 1992 |
Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins.
Topics: Animals; Binding, Competitive; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; In Vitro Techniques; Magnesium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Swine | 1992 |
Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischaemia.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Carbachol; Colforsin; Coronary Disease; Dogs; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Receptors, Muscarinic | 1992 |
The nature and origin of spontaneous noise in G protein-gated ion channels.
Topics: Adrenocorticotropic Hormone; Animals; Biological Transport, Active; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Ion Channel Gating; Magnesium; Membrane Potentials; Potassium; Potassium Channels | 1991 |
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Carbachol; Cell Line; Dihydropyridines; Electric Conductivity; GTP-Binding Proteins; Guanosine Triphosphate; Molecular Weight; Pertussis Toxin; Photochemistry; Pituitary Gland; Prolactin; Rats; Receptors, Muscarinic; Virulence Factors, Bordetella | 1991 |
Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Atropine; Carbachol; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fishes; GTP-Binding Proteins; Guanosine Triphosphate; Pertussis Toxin; Retina; Serotonin; Sodium Fluoride; Tetrahydronaphthalenes; Virulence Factors, Bordetella | 1990 |
Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
Topics: Animals; Bucladesine; Calcium; Carbachol; Cells, Cultured; Charybdotoxin; Cobalt; Electric Conductivity; Evoked Potentials; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Regulation of GDP and GTP binding in cardiac sarcolemma by muscarinic receptor agonists.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atropine; Carbachol; Dogs; Ethylmaleimide; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Heart; Kinetics; Myocardium; Receptors, Muscarinic; Sarcolemma; Time Factors | 1992 |
Magnesium reversal of lithium inhibition of beta-adrenergic and muscarinic receptor coupling to G proteins.
Topics: Animals; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Isoproterenol; Lithium; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1991 |
Guanosine 5'-triphosphate converts some populations of propylbenzilylcholine mustard-sensitive muscarinic cholinoceptor sites to sites resistant to the drug in intestinal smooth muscle.
Topics: Alkylation; Animals; Carbachol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Kinetics; Membranes; Muscle, Smooth; Propylbenzilylcholine Mustard; Proteins; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1991 |
Depolarization-induced changes in the muscarinic receptor in rat brain and heart are mediated by pertussis-toxin-sensitive G-proteins.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Atropine; Brain; Carbachol; Cell Membrane Permeability; Cells, Cultured; Chromatography, Thin Layer; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Male; Membrane Potentials; Myocardium; Pertussis Toxin; Rats; Receptors, Muscarinic; Synaptosomes; Virulence Factors, Bordetella | 1991 |
Atropine dissociates complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein in heart membranes.
Topics: Animals; Atropine; Blotting, Western; Carbachol; Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; Myocardium; Rats; Receptors, Muscarinic | 1991 |
Phosphoinositide breakdown in isolated myelin is stimulated by GTP analogues and calcium.
Topics: Animals; Calcium; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol Phosphates; Myelin Proteins; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Second Messenger Systems | 1990 |
Beta gamma dimers of G proteins inhibit atrial muscarinic K+ channels.
Topics: Acetylcholine; Animals; Atrial Function; Carbachol; Erythrocytes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; Humans; In Vitro Techniques; Kinetics; Macromolecular Substances; Potassium Channels; Protein Multimerization; Thionucleotides | 1990 |
Carbamylcholine inhibits beta-adrenergic receptor-coupled Gs protein function proximal to adenylate cyclase.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Binding Sites; Carbachol; Cell Membrane; Cholera Toxin; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Isoproterenol; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1990 |
Guanosine 5'-O-thiotriphosphate and sodium fluoride activate polyphosphoinositide hydrolysis in rat cortical membranes by distinct mechanisms.
Topics: Animals; Biomechanical Phenomena; Calcium; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Membranes; Phosphatidylinositols; Rats; Sodium Fluoride; Thionucleotides | 1990 |
Guanine nucleotides have a direct inhibitory effect on polyphosphoinositide turnover in rat cortical synaptosomes.
Topics: Animals; Carbachol; Cerebral Cortex; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Phosphates; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C.
Topics: Alkaloids; Animals; Atropine; Calcimycin; Calcium; Carbachol; Cell Line; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytosol; GTP-Binding Proteins; Guanosine Triphosphate; Inositol Phosphates; Kinetics; Norepinephrine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Regulation of cardiac pacemaker current If in excised membranes from sinoatrial node cells.
Topics: Animals; Carbachol; Cell Membrane; Electrophysiology; Guanosine Triphosphate; Heart Conduction System; Parasympathomimetics; Receptors, Adrenergic, beta; Sinoatrial Node | 1990 |
Dual effect of fluoride on phosphoinositide metabolism in rat brain cortex. Stimulation of phospholipase C and inhibition of polyphosphoinositide synthesis.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Carbachol; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Rats; Sodium Fluoride; Thionucleotides; Type C Phospholipases | 1990 |
Activation of phospholipase C in rabbit brain membranes by carbachol in the presence of GTP gamma S; effects of biological detergents.
Topics: Animals; Brain; Carbachol; Cell Membrane; Detergents; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rabbits; Thionucleotides; Type C Phospholipases; Uncoupling Agents | 1990 |
Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma.
Topics: 4-Nitrophenylphosphatase; Animals; Carbachol; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Myocardium; Ouabain; Pertussis Toxin; Potassium; Rabbits; Receptors, Muscarinic; Sarcolemma; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Swine; Virulence Factors, Bordetella | 1990 |
Alterations in receptor-coupled second messenger systems at up-regulated muscarinic receptors: analysis using primary cultured neurons.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cyclic GMP; Cycloheximide; Female; Guanosine Triphosphate; Hydrolysis; Kinetics; Mice; Mice, Inbred Strains; Neurons; Phosphatidylinositols; Pregnancy; Quinuclidinyl Benzilate; Receptors, Muscarinic; Second Messenger Systems; Up-Regulation | 1990 |
Signaling through the muscarinic receptor-adenylate cyclase system of the heart is buffered against GTP over a range of concentrations.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
Characterization of receptors for VIP on pancreatic acinar cell plasma membranes using covalent cross-linking.
Topics: Animals; Bombesin; Carbachol; Cell Membrane; Cross-Linking Reagents; Growth Hormone-Releasing Hormone; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Molecular Weight; Pancreas; Peptide PHI; Peptides; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Secretin; Sincalide; Substance P; Vasoactive Intestinal Peptide | 1987 |
The dynamics of cGMP metabolism in neuroblastoma N1E-115 cells determined by 18O labeling of guanine nucleotide alpha-phosphoryls.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine Nucleotides; Animals; Carbachol; Cell Line; Cyclic AMP; Cyclic GMP; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Isotope Labeling; Kinetics; Neuroblastoma; Nitroprusside; Oxygen Radioisotopes | 1987 |
Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes.
Topics: Animals; Carbachol; Cell Membrane; Clone Cells; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channels; Membrane Potentials; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Rats; Receptors, Muscarinic; Somatostatin; Thionucleotides | 1987 |
A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels.
Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Atrial Function; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Ion Channels; Myocardium; Potassium; Receptors, Muscarinic; Thionucleotides | 1988 |
A G-protein mediates secretagogue-induced gap junctional channel closure in pancreatic acinar cells.
Topics: Animals; Carbachol; Cyclohexanones; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intercellular Junctions; Ion Channels; Kinetics; Lipase; Male; Mice; Mice, Inbred Strains; Pancreas; Thionucleotides | 1989 |
Trypsin activation of atrial muscarinic K+ channels.
Topics: Animals; Carbachol; Cells, Cultured; GTP-Binding Proteins; Guanosine Triphosphate; Myocardium; Potassium Channels; Rats; Receptors, Muscarinic; Trypsin | 1989 |
Possible involvement of a G-protein in carbamylcholine-induced gap junction closure.
Topics: Acetylcholine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Carbachol; Diglycerides; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intercellular Junctions; Lacrimal Apparatus; Membrane Potentials; Protein Kinase C; Rats; Thionucleotides; Type C Phospholipases | 1989 |
Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes.
Topics: Animals; Carbachol; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; Kinetics; Myocardium; NAD; Pertussis Toxin; Receptors, Muscarinic; Swine; Thionucleotides; Virulence Factors, Bordetella | 1989 |
G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland.
Topics: Adenylate Cyclase Toxin; Animals; Calcium; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoproterenol; Kinetics; Mucous Membrane; Pertussis Toxin; Phosphatidylinositols; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland; Thionucleotides; Virulence Factors, Bordetella | 1989 |
Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan.
Topics: Bee Venoms; Calcium; Carbachol; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Neuroblastoma; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Thionucleotides; Tumor Cells, Cultured; Type C Phospholipases; Wasp Venoms | 1989 |
Actions of guanine nucleotides and cyclic nucleotides on calcium stores in single patch-clamped smooth muscle cells from rabbit portal vein.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Caffeine; Calcium; Carbachol; Cyclic AMP; Cyclic GMP; Female; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Rabbits; Ryanodine | 1989 |
Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes.
Topics: Aluminum; Animals; Carbachol; Cerebral Cortex; Enzyme Activation; Fluorine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Hydrolysis; Male; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Thionucleotides | 1989 |
Autonomic receptor interactions in isolated cardiac myocytes from hypertensive rats.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Carbachol; Guanosine Triphosphate; Hypertension; In Vitro Techniques; Iodocyanopindolol; Isoproterenol; Kinetics; Male; Myocardium; Pindolol; Quinuclidinyl Benzilate; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Receptors, Cholinergic | 1989 |
Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbachol; Cell Membrane; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Substrate Specificity; Thionucleotides; Type C Phospholipases | 1989 |
Modulation of carbachol-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.
Topics: Animals; Carbachol; Cell Membrane; Cerebral Cortex; Chlorides; Guanosine Triphosphate; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Lithium; Lithium Chloride; Male; Phosphatidylinositols; Rats; Sugar Phosphates; Tritium | 1987 |
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Cell Line; Cricetinae; Cyclic AMP; Gene Expression Regulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Receptors, Muscarinic; Recombinant Proteins; Thionucleotides; Virulence Factors, Bordetella | 1987 |
Guanine nucleotide-dependent inositol trisphosphate formation in chick heart cells.
Topics: Animals; Carbachol; Cells, Cultured; Chick Embryo; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Myocardium; Phosphatidylinositols; Sugar Phosphates; Thionucleotides; Type C Phospholipases | 1988 |
Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells.
Topics: Animals; Carbachol; Carrier Proteins; Cells, Cultured; Cerebellum; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Pertussis Toxin; Phospholipids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Thionucleotides; Virulence Factors, Bordetella | 1988 |
Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Guinea Pigs; Ileum; Muscle, Smooth; N-Methylscopolamine; Oxotremorine; Parotid Gland; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
G-protein involvement in central-nervous-system muscarinic-receptor-coupled polyphosphoinositide hydrolysis.
Topics: Animals; Carbachol; Carrier Proteins; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Male; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thionucleotides; Type C Phospholipases | 1988 |
(R)-nipecotic acid ethyl ester: a direct-acting cholinergic agonist that displays greater efficacy at M2 than at M1 muscarinic receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Bethanechol; Bethanechol Compounds; Binding, Competitive; Carbachol; Cerebral Cortex; Corpus Striatum; Depression, Chemical; Guanosine Triphosphate; Guinea Pigs; Ileum; Jejunum; Male; Muscle Contraction; Myocardial Contraction; Nipecotic Acids; Phosphates; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1987 |
Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Carbachol; Cyclic AMP; Guanosine Triphosphate; Male; Norepinephrine; Pertussis Toxin; Prazosin; Rats; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1985 |
Comparison of cholinergic inhibition and beta-adrenergic stimulation of adenylate cyclase from rat and guinea-pig hearts: effects of guanine nucleotides and monovalent cations.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Carbachol; Cations, Monovalent; Chlorides; Colforsin; Cytosol; Enzyme Activation; Female; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Isoproterenol; Lithium; Lithium Chloride; Male; Myocardium; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Sodium Fluoride; Tissue Distribution | 1985 |
A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol Phosphates; Male; Parotid Gland; Propranolol; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Sodium Fluoride; Thionucleotides; Type C Phospholipases | 1986 |
Autonomic interactions in the aging heart: age-associated decrease in muscarinic cholinergic receptor mediated inhibition of beta-adrenergic activation of adenylate cyclase.
Topics: Adenylyl Cyclases; Aging; Animals; Atropine; Carbachol; Cell Membrane; Enzyme Activation; Guanosine Triphosphate; Isoproterenol; Male; Myocardium; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1986 |
Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carbachol; Ceruletide; Ethers; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol Phosphates; Ionomycin; Ionophores; Male; Pancreas; Phosphatidylinositols; Rats; Rats, Inbred Strains; Thionucleotides; Type C Phospholipases | 1986 |
Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.
Topics: Adenoma, Islet Cell; Carbachol; Cell Line; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol Phosphates; Pancreatic Neoplasms; Thionucleotides; Type C Phospholipases | 1987 |
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
Topics: Adenylate Cyclase Toxin; Animals; Binding, Competitive; Brain; Carbachol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liposomes; Magnesium; Pertussis Toxin; Phospholipids; Rats; Receptors, Muscarinic; Scopolamine; Swine; Thionucleotides; Virulence Factors, Bordetella | 1986 |
Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Atropine; Carbachol; Chick Embryo; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Isoproterenol; Kinetics; Myocardium; Pertussis Toxin; Receptors, Muscarinic; Virulence Factors, Bordetella | 1986 |
Type II heat-labile enterotoxin of Escherichia coli activates adenylate cyclase in human fibroblasts by ADP ribosylation.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Alprostadil; Bacterial Toxins; Carbachol; Cholera Toxin; Dithiothreitol; Enterotoxins; Enzyme Activation; Escherichia coli Proteins; Fibroblasts; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoproterenol; NAD; Trypsin | 1987 |
Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Cell Membrane; Chick Embryo; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Myocardium; Receptors, Muscarinic | 1987 |
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
Topics: Adenosine Diphosphate Ribose; Animals; Carbachol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; Kinetics; Mathematics; Myocardium; Receptors, Muscarinic; Swine; Thionucleotides | 1987 |
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate Ribose; Animals; Carbachol; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Male; Pancreas; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Receptors, Cholinergic; Sincalide; Thionucleotides; Type C Phospholipases; Vasoactive Intestinal Peptide | 1988 |
Diethyl ether effects on muscarinic acetylcholine receptor complexes in rat brainstem.
Topics: Animals; Brain Stem; Carbachol; Ether; Ethyl Ethers; GTP-Binding Proteins; Guanosine Triphosphate; Halothane; In Vitro Techniques; Male; Oxotremorine; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.
Topics: Animals; Calcium; Carbachol; Dialysis; Egtazic Acid; Evoked Potentials; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intestine, Small; Iontophoresis; Muscle, Smooth; Rabbits; Receptors, Muscarinic; Thionucleotides | 1988 |
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Topics: Adenylyl Cyclases; Animals; Atropine; Carbachol; Dogs; Female; Guanosine Triphosphate; Heart Failure; Heart Ventricles; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Myocardium; Oxotremorine; Receptors, Muscarinic; Sarcolemma | 1988 |
Potentiation by glucose metabolites of inositol trisphosphate-induced calcium mobilization in permeabilized rat pancreatic islets.
Topics: Animals; Calcium; Carbachol; Cell Membrane Permeability; Diphosphoglyceric Acids; Fructosediphosphates; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hexosediphosphates; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Islets of Langerhans; Rats; Saponins; Sugar Phosphates; Thionucleotides | 1987 |
Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex.
Topics: Animals; Atropine; Bipolar Disorder; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Isoproterenol; Lithium; Male; Propranolol; Rats | 1988 |
Agonist and antagonist binding of muscarinic acetylcholine receptors purified from porcine brain: interconversion of high- and low-affinity sites by sulfhydryl reagents.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Carbachol; Centrifugation, Density Gradient; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Oxidation-Reduction; Parasympathomimetics; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sulfhydryl Compounds; Sulfhydryl Reagents; Swine | 1988 |
Characterization of M1- and M2-muscarinic receptors in calf retina membranes.
Topics: Animals; Binding, Competitive; Carbachol; Cattle; Ethylmaleimide; Guanosine Triphosphate; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Retina | 1988 |
Photoaffinity labeling with GTP-gamma-azidoanilide of a cholera toxin-sensitive 40 kDa protein from pancreatic acinar cells.
Topics: Adenylyl Cyclases; Affinity Labels; Animals; Azides; Carbachol; Cholera Toxin; Guanosine Triphosphate; Membrane Proteins; Molecular Weight; Pancreas; Photochemistry; Rats; Secretin; Sincalide; Vasoactive Intestinal Peptide | 1988 |
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.
Topics: Bradykinin; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histamine; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Membranes; Phorbol Esters; Protein Kinase C; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Different agonist binding properties of M1 and M2 muscarinic receptors in calf brain cortex membranes.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Cattle; Cell Membrane; Cerebral Cortex; Ethylmaleimide; Guanosine Triphosphate; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1987 |
Pertussis vaccine reduces agonist binding to the rat heart muscarinic receptor and its guanine nucleotide modulation.
Topics: Animals; Carbachol; Cell Membrane; Female; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Myocardium; Pertussis Vaccine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic | 1986 |
Molecular distinction between calf heart and brain muscarine receptors: different N-ethylmaleimide modulation of agonist binding.
Topics: Animals; Atropine; Binding, Competitive; Brain; Carbachol; Cattle; Ethylmaleimide; Guanosine Triphosphate; In Vitro Techniques; Myocardium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Solubility | 1986 |
Identification of M2 muscarinic receptors in membranes from bovine cerebral basal arteries.
Topics: Animals; Carbachol; Cattle; Cerebral Arteries; Cerebral Cortex; Ethylmaleimide; Guanosine Triphosphate; Membranes; Myocardium; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1986 |
Reconstitution of muscarinic cholinergic inhibition of adenylate cyclase activity in homogenates of embryonic chick hearts by membranes of adult chick hearts.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Carbachol; Cell Extracts; Cell Membrane; Chick Embryo; Chickens; Guanosine Triphosphate; Heart; Isoproterenol; Myocardium; Pertussis Toxin; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tissue Extracts; Virulence Factors, Bordetella | 1987 |
Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Atropine; Bacterial Toxins; Carbachol; Cell Line; Cell Membrane; Enkephalin, Methionine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Membrane Proteins; Naloxone; Norepinephrine; Nucleoside Diphosphate Sugars; Pertussis Toxin; Phentolamine; Transducin; Virulence Factors, Bordetella | 1985 |
Muscarinic cholinergic receptors in human foetal brain: characterization and ontogeny of [3H]quinuclidinyl benzilate binding sites in frontal cortex.
Topics: Adolescent; Adult; Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Child, Preschool; Female; Fetus; Guanosine Triphosphate; Humans; Middle Aged; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Sodium Chloride | 1985 |
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.
Topics: Astrocytoma; Atropine; Carbachol; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Guanosine Triphosphate; Humans; Kinetics; N-Methylscopolamine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives | 1985 |
The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Guanosine Triphosphate; In Vitro Techniques; Male; Models, Structural; Myocardium; N-Methylscopolamine; Oxotremorine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1985 |
Development and regulation of cardiac muscarinic acetylcholine receptor number, function and guanyl nucleotide sensitivity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Atrial Function; Atropine; Binding, Competitive; Carbachol; Chick Embryo; Guanosine Triphosphate; Heart Atria; Kinetics; Myocardial Contraction; Receptors, Cholinergic; Receptors, Muscarinic | 1983 |
Guanine nucleotide sensitivity of muscarinic acetylcholine receptors from rat brainstem is eliminated by endogenous proteolytic activity.
Topics: Animals; Brain Stem; Carbachol; Endopeptidases; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Protease Inhibitors; Rats; Receptors, Muscarinic | 1984 |
Fatty acid incorporation increases the affinity of muscarinic cholinergic receptors for agonists.
Topics: Animals; Benzilates; Carbachol; Cell Membrane; Cerebral Cortex; Cobalt; Fatty Acids; Guanosine Triphosphate; Medulla Oblongata; Piperidines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1984 |
Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atrial Function; Bacterial Toxins; Carbachol; Chick Embryo; Depression, Chemical; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Heart; Heart Rate; Isoproterenol; Myocardium; Pertussis Toxin; Quinuclidinyl Benzilate; Receptors, Muscarinic; Virulence Factors, Bordetella | 1984 |
Muscarinic acetylcholine receptors in Torpedo electric organ: effect of guanine nucleotides.
Topics: Animals; Binding, Competitive; Carbachol; Electric Organ; Electrophoresis; Guanosine Triphosphate; Kinetics; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic | 1983 |
Muscarinic receptors in the stomach.
Topics: Animals; Benzodiazepinones; Carbachol; Dogs; Gastric Fundus; Gastric Mucosa; Guanosine Triphosphate; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Piperazines; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Sympathetic Nervous System | 1980 |
The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.
Topics: Animals; Carbachol; Cell Membrane; Cells, Cultured; Chick Embryo; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Myocardium; N-Methylscopolamine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1982 |
Molecular mechanism of the effects of guanine nucleotide and sulfhydryl reagent on muscarinic receptors in smooth muscles studied by radiation inactivation.
Topics: Animals; Carbachol; Guanine Nucleotides; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Sulfhydryl Reagents | 1982 |
Cardiac muscarinic cholinergic receptor sites: opposing regulation by divalent cations and guanine nucleotides of receptor-agonist interaction.
Topics: Animals; Atropine; Binding Sites; Calcium; Carbachol; Dose-Response Relationship, Drug; Guanosine Triphosphate; In Vitro Techniques; Magnesium; Myocardium; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1980 |
Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone--like manner.
Topics: Adenylyl Cyclase Inhibitors; Adipose Tissue; Animals; Blood Platelets; Carbachol; Cricetinae; Epinephrine; Guanosine Triphosphate; Humans; Kinetics; Male; Mesocricetus; Myocardium; Nicotinic Acids; Prostaglandins E; Rabbits | 1980 |
Stable cholinergic-muscarinic and alpha-adrenergic inhibition of rat parotid adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium; Carbachol; Dogs; Guanosine Triphosphate; Male; Manganese; Membranes; Methoxamine; Myocardium; Parotid Gland; Rats | 1980 |
Requirement for sulfhydryl groups in the differential effects of magnesium ion and GTP on agonist binding of muscarinic cholinergic receptor sites in rat atrial membrane fraction.
Topics: Animals; Atropine; Carbachol; Dithiothreitol; Ethylmaleimide; Guanosine Triphosphate; Magnesium; Male; Membranes; Myocardium; Parasympathomimetics; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Sulfhydryl Compounds | 1980 |
Infusion of guanine nucleotides through recording electrodes for studies on G-protein regulation of ion currents and channels.
Topics: Animals; Baclofen; Carbachol; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Ion Channels; Membrane Potentials; Microelectrodes; Pyramidal Cells; Rats; Serotonin; Thionucleotides | 1994 |
Reconstitution of receptor-regulated ion channels in isolated patch membrane.
Topics: Acetylcholine; Animals; Carbachol; Cell Membrane; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Receptors, Muscarinic; Virulence Factors, Bordetella | 1994 |
Effects of high-energy phosphates on carbachol-evoked cationic current in single smooth muscle cells from guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Carbachol; Cations; Cell Membrane Permeability; Guanosine Triphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Phosphocreatine | 1995 |
GTPase activity in mouse hippocampus membranes following prenatal exposure to heroin and phenobarbital.
Topics: Animals; Carbachol; Cell Membrane; Enzyme Activation; Female; GTP Phosphohydrolases; Guanosine Triphosphate; Heroin; Hippocampus; Hydrolysis; Mice; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects | 1995 |
Unusual carbachol responses in RINm5F cells: evidence for a "distal" site of action in stimulus-secretion coupling.
Topics: Arachidonic Acid; Calcium; Carbachol; Cells, Cultured; Guanosine Triphosphate; Insulin; Insulin Secretion; Membrane Potentials; Protein Kinase C; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Possible involvement of a small G-protein sensitive to exoenzyme C3 of Clostridium botulinum in the regulation of myofilament Ca2+ sensitivity in beta-escin skinned smooth muscle of guinea pig ileum.
Topics: Animals; Calcium; Carbachol; Complement C3; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth | 1995 |
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; Female; Frontal Lobe; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Male; Middle Aged; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Pirenzepine; Receptors, Muscarinic; Reference Values; Regression Analysis; Synaptic Membranes; Synaptosomes | 1995 |
Transduction mechanism of motilin and motilides in rabbit duodenal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Carbachol; Duodenum; Erythromycin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol; Inositol Phosphates; Motilin; Muscle, Smooth; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Signal Transduction; Tritium | 1995 |
Differential time course for desensitization to muscarinic effects on K+ and Ca2+ channels.
Topics: Acetylcholine; Animals; Calcium Channels; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Muscarine; Parasympathetic Nervous System; Potassium Channels | 1994 |
Signal transduction pathways of muscarinic receptors in circular smooth muscle from the rabbit caecum.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Cecum; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Inositol Phosphates; Male; Muscarinic Antagonists; Muscle, Smooth; Pertussis Toxin; Rabbits; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system.
Topics: Animals; Baculoviridae; Brain; Carbachol; Cattle; Cell Line; Chromatography; Chromatography, Ion Exchange; Durapatite; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Receptors, Muscarinic; Recombinant Proteins; Spodoptera; Transfection; Type C Phospholipases | 1995 |
Characterization of GTP-binding proteins coupled to inhibition of adenylyl cyclase in guinea pig tracheal epithelial cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atropine; Carbachol; Cell Membrane; Cells, Cultured; Cholera Toxin; Cyclic AMP; Epithelial Cells; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Kinetics; Male; Pertussis Toxin; Receptors, Muscarinic; Sodium Fluoride; Specific Pathogen-Free Organisms; Trachea; Virulence Factors, Bordetella | 1994 |
Mobilization of Ca2+ influx, but not of stored Ca2+, by extracellular ATP in rat submandibular gland acini.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Guanosine Triphosphate; Hexokinase; Magnesium; Male; Nifedipine; Pancreas; Rats; Rats, Sprague-Dawley; Submandibular Gland; Uridine Triphosphate; Verapamil | 1994 |
Deletion analysis of the m4 muscarinic acetylcholine receptor. Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Carbachol; CHO Cells; Colforsin; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Mice; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Protein Structure, Secondary; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; Sequence Deletion; Transfection | 1994 |
Chronic desipramine treatment influences D1 stimulation and D2 inhibition (dual control) of adenylate cyclase by dopamine in rat striatum.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Benzazepines; Carbachol; Corpus Striatum; Desipramine; Dopamine; Guanosine Triphosphate; Male; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1994 |
Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity.
Topics: Adenylyl Cyclases; Animals; Atropine; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Muscarinic; Receptors, Platelet-Derived Growth Factor; Transfection | 1994 |
Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.
Topics: Affinity Labels; Amino Acid Sequence; Azides; Carbachol; Cells, Cultured; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Molecular Sequence Data; Pertussis Toxin; Phospholipase D; Photochemistry; Receptors, Muscarinic; Recombinant Proteins; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
(+-)-Methyl-2,3,3a,4-tetrahydro-1H-indolo [3,2,1-de] [1,5] naphthyridine-6-carboxylate monohydrochloride facilitates phosphatidylinositol hydrolysis: possible involvement of muscarinic and nonmuscarinic mechanisms.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Hypoxia; In Vitro Techniques; Inositol Phosphates; Ketanserin; Male; Phentolamine; Phosphatidylinositols; Potassium; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Synaptic Membranes; Vinca Alkaloids | 1993 |
Serotonin-induced muscle contraction in rat stomach fundus is mediated by a G alpha z-like guanine nucleotide binding protein.
Topics: Amino Acid Sequence; Animals; Carbachol; Gastric Mucosa; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Membranes; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach; Sulfur Radioisotopes | 1993 |
Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes.
Topics: Adenosine Triphosphate; Aged; Aluminum Compounds; Brain; Calcium; Carbachol; Cell Membrane; Cycloleucine; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Hydrolysis; Male; Neurotoxins; Phosphatidylinositols; Pilocarpine; Postmortem Changes; Second Messenger Systems; Serotonin; Type C Phospholipases | 1994 |
Muscarinic receptor-mediated inhibition of GDP-activated adenylyl cyclase suggests a direct interaction of inhibitory guanine nucleotide-binding proteins and adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Carbachol; Dogs; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Nucleoside-Diphosphate Kinase; Receptors, Muscarinic | 1993 |
Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.
Topics: Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Genistein; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Isoflavones; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptors, Muscarinic; Recombinant Proteins; Scopolamine; Transfection | 1993 |
Co-culture of embryonic chick heart cells and ciliary ganglia induces parasympathetic responsiveness in embryonic chick heart cells.
Topics: Animals; Carbachol; Cells, Cultured; Chick Embryo; Culture Media, Conditioned; Ganglia, Parasympathetic; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Myocardium | 1993 |
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.
Topics: Animals; Calcium; Carbachol; Cell Line; Cell Membrane Permeability; Cloning, Molecular; Endothelins; Enterotoxins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ileum; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth; Muscle, Smooth, Vascular; Pertussis Toxin; Phenylephrine; Rabbits; Recombinant Proteins; rhoA GTP-Binding Protein; Spodoptera; Staphylococcus aureus; Virulence Factors, Bordetella | 1996 |
G-protein coupling of muscarinic receptors in adult and neonatal rat submandibular cells.
Topics: Age Factors; Animals; Animals, Newborn; Carbachol; Female; GTP-Binding Proteins; Guanosine Triphosphate; Male; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Submandibular Gland | 1996 |
Agonists increase the sensitivity of contractile elements for Ca++ in pregnant rat myometrium.
Topics: Animals; Calcium; Carbachol; Enzyme Inhibitors; Ethers, Cyclic; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Muscarinic Agonists; Myometrium; Okadaic Acid; Potassium; Pregnancy; Prostaglandins; Rats; Rats, Sprague-Dawley; Uterine Contraction | 1996 |
Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-X-X-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Carbachol; Cell Membrane; CHO Cells; Conserved Sequence; Cricetinae; DNA Primers; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Oxotremorine; Protein Structure, Secondary; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Second Messenger Systems; Transfection | 1996 |
Evidence against a regulation of Na+/K(+)-ATPase by Gi proteins. Failure to detect an influence of G proteins on Na+/Ca(2+)-exchange in cardiac sarcolemmal membranes.
Topics: 4-Nitrophenylphosphatase; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Calcium; Carbachol; Carrier Proteins; Dogs; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Muscarinic Agonists; Myocardial Contraction; Myocardium; Phenylisopropyladenosine; Potassium Channels; Receptors, Muscarinic; Receptors, Purinergic P1; Sarcolemma; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase | 1996 |
Role for GTP in glucose-induced phospholipase C activation in pancreatic islets.
Topics: Animals; Calcium; Carbachol; Enzyme Activation; Glucose; Guanine; Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Islets of Langerhans; Male; Mycophenolic Acid; Phosphatidylinositols; Phospholipids; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 1996 |
Formation of the functional complexes of m2 muscarinic acetylcholine receptors with GTP-binding regulatory proteins in solution.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Detergents; GTP-Binding Proteins; Guanosine Triphosphate; Heart Atria; Magnesium; Muscarinic Agonists; Muscarinic Antagonists; Protein Binding; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Spodoptera; Swine | 1996 |
Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle.
Topics: Adenosine Diphosphate Ribose; Animals; Bacterial Proteins; Bacterial Toxins; Calcium; Carbachol; Cholinergic Agonists; Escin; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Recombinant Proteins; rhoA GTP-Binding Protein | 1996 |
A novel GTP-dependent mechanism of ileal muscarinic metabotropic channel desensitization.
Topics: Animals; Carbachol; Guanosine Triphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscle, Smooth; Receptors, Muscarinic | 1996 |
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.
Topics: Animals; Astrocytes; Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; COS Cells; DNA; Gene Expression Regulation; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Muscarinic Agonists; Pertussis Toxin; Protein Kinase C; ras Proteins; Receptors, Muscarinic; Receptors, Thrombin; Signal Transduction; Thrombin; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1996 |
Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells.
Topics: Alamethicin; Calcium; Carbachol; Cell Division; Colonic Neoplasms; Deoxycholic Acid; Enzyme Activation; Fatty Acids; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Membrane Lipids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Sphingomyelins; Tumor Cells, Cultured; Type C Phospholipases | 1996 |
Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.
Topics: Adenylyl Cyclases; Animals; Carbachol; CHO Cells; Cricetinae; Down-Regulation; Endocytosis; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Inositol Phosphates; Microscopy, Confocal; Muscarinic Agonists; Mutation; Receptors, Cell Surface; Receptors, Muscarinic; Signal Transduction; Subcellular Fractions; Sulfur Radioisotopes; Transfection; Type C Phospholipases | 1997 |
Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Age Factors; Animals; Animals, Newborn; Body Weight; Carbachol; Cell Membrane; Colforsin; Drug Hypersensitivity; Female; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Isoproterenol; Male; Manganese; Membrane Proteins; Muscarinic Agonists; Myocardium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Time Factors | 1997 |
G proteins activate ionic conductances at multiple sites in T84 cells.
Topics: Calcium; Carbachol; Electric Conductivity; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Ions; Oscillometry; Parasympathomimetics; Potassium; Tumor Cells, Cultured | 1997 |
A9 fibroblasts transfected with the m3 muscarinic receptor clone express a Ca2+ channel activated by carbachol, GTP and GDP.
Topics: Animals; Calcium Channels; Carbachol; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Membrane Potentials; Patch-Clamp Techniques; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Thionucleotides; Transfection | 1997 |
Chronic carbachol pretreatment decreases adenylyl cyclase activity in airway smooth muscle.
Topics: Adenylyl Cyclases; Animals; Atropine; Carbachol; Cattle; Guanosine Triphosphate; In Vitro Techniques; Isoproterenol; Kinetics; Muscle, Smooth; Protein Kinase C; Receptor, Muscarinic M3; Receptors, Muscarinic; Staurosporine; Trachea | 1997 |
[Gamma-35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum.
Topics: Animals; Animals, Newborn; Autoradiography; Carbachol; Chickens; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Male; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Sulfur Radioisotopes; Superior Colliculi; Time Factors; Tissue Distribution | 1997 |
Differences in the stimulation of the phosphoinositide cycle by amine neurotransmitters in cultured rat forebrain neurones and astrocytes.
Topics: Animals; Astrocytes; Calcium; Carbachol; Cells, Cultured; Guanosine Triphosphate; Histamine; Neurons; Norepinephrine; Phosphatidylinositols; Prosencephalon; Rats; Rats, Sprague-Dawley | 1997 |
Modulation of the in situ activity of tissue transglutaminase by calcium and GTP.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; Calcium; Calcium Channel Agonists; Calpain; Carbachol; Diazomethane; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ionomycin; Ionophores; Marine Toxins; Muscarinic Agonists; Oligopeptides; Oxocins; Receptors, Retinoic Acid; Retinoid X Receptors; Ribavirin; Thapsigargin; Transcription Factors; Transglutaminases; Tumor Cells, Cultured | 1998 |
Muscarinic cation current and suppression of Ca2+ current in guinea pig ileal smooth muscle cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Male; Muscarinic Agonists; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pertussis Toxin; Receptors, Muscarinic; Virulence Factors, Bordetella | 1998 |
InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle.
Topics: Adenosine Diphosphate Ribose; Administration, Topical; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Anticoagulants; Bronchi; Caffeine; Calcium; Carbachol; Central Nervous System Stimulants; Dimethyl Sulfoxide; Guanosine Triphosphate; Guinea Pigs; Heparin; Humans; Ileum; Immunosuppressive Agents; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; NADP; Parasympathomimetics; Procaine; Rabbits; Ryanodine; Species Specificity; Tacrolimus; Trachea; Type C Phospholipases | 1998 |
The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain.
Topics: 3T3 Cells; Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Conserved Sequence; COS Cells; DNA-Binding Proteins; Enzyme Activation; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; JNK Mitogen-Activated Protein Kinases; Kinetics; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphoproteins; Receptors, Muscarinic; Recombinant Proteins; Repressor Proteins; Serine; Transfection | 1998 |
The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D.
Topics: ADP-Ribosylation Factors; Carbachol; Cell Adhesion Molecules; Cell Line; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Humans; Membrane Proteins; Phospholipase D; Proteins; Receptor, Muscarinic M3; Receptors, Muscarinic; Sequence Homology, Amino Acid; Signal Transduction; Yeasts | 1999 |
Dopamine receptor coupling to adenylyl cyclase in rat olfactory pathway: a combined pharmacological-radioautographic approach.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Autoradiography; Benzazepines; Bromocriptine; Carbachol; Colforsin; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Male; Muscarinic Agonists; Nitriles; Odorants; Olfactory Bulb; Olfactory Mucosa; Olfactory Pathways; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Signal Transduction | 1999 |
Gialpha but not gqalpha is linked to activation of p21(ras) in human airway smooth muscle cells.
Topics: Bradykinin; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Histamine; Humans; Muscle, Smooth; Peptide Fragments; Pertussis Toxin; Potassium Chloride; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Trachea; Transfection; Virulence Factors, Bordetella | 1999 |
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle.
Topics: Animals; Blotting, Western; Calcium Signaling; Carbachol; Cell Membrane; Enzyme Inhibitors; Gonadal Steroid Hormones; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Isometric Contraction; Marine Toxins; Muscarinic Agonists; Muscle, Smooth; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Recombinant Proteins; rho GTP-Binding Proteins | 1999 |
A fluorometric assay for cyclic guanosine 3',5'-monophosphate incorporating a Sep-Pak cartridge and enzymatic cycling.
Topics: Animals; Atrial Function, Left; Calibration; Carbachol; Coenzyme A Ligases; Cyclic GMP; Dogs; Female; Guanosine Triphosphate; Heart; Indicators and Reagents; L-Lactate Dehydrogenase; Male; Myocardium; NAD; Phosphorylation; Pyruvate Kinase; Sensitivity and Specificity; Spectrometry, Fluorescence | 1999 |
TSH and cAMP do not signal mitogenesis through Ras activation.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cell Cycle; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Activation; Epidermal Growth Factor; Guanosine Triphosphate; Hepatocyte Growth Factor; Insulin; Mitogens; ras Proteins; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors | 2000 |
Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling.
Topics: Animals; Carbachol; Caveolin 1; Caveolins; Cell Membrane; Cells, Cultured; Cholinergic Agonists; COS Cells; Dose-Response Relationship, Drug; Dynamins; Endothelium, Vascular; Genes, Dominant; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Immunoblotting; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Receptors, Cell Surface; Receptors, Muscarinic; Recombinant Proteins; Signal Transduction; Time Factors; Transfection | 2000 |
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Chickens; Enzyme Inhibitors; Female; Gene Expression; Gizzard, Avian; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Verapamil | 2000 |
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
Topics: Affinity Labels; Animals; Azides; Carbachol; Cholera Toxin; Cholinergic Agonists; Elapid Venoms; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Hydrolysis; In Vitro Techniques; Male; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphorus Radioisotopes; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Specific Pathogen-Free Organisms; Sublingual Gland; Virulence Factors, Bordetella | 2001 |
Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels.
Topics: Acetylcholine; Animals; Animals, Newborn; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heart Atria; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Time Factors; Transfection; Trypsin | 2001 |
Receptor crosstalk protein, calcyon, regulates affinity state of dopamine D1 receptors.
Topics: Apomorphine; Benzazepines; Binding, Competitive; Carbachol; Cell Line; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine Triphosphate; Humans; Membrane Proteins; Radioligand Assay; Receptor Cross-Talk; Receptors, Dopamine D1; Tritium | 2001 |
Phosphatidylinositol 4,5-bisphosphate modifies tubulin participation in phospholipase Cbeta1 signaling.
Topics: Animals; Azides; Carbachol; Cell Line; Cell Membrane; Cholinergic Agonists; Dose-Response Relationship, Drug; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Hydrolysis; Isoenzymes; Luminescent Proteins; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Signal Transduction; Spodoptera; Transfection; Tubulin; Type C Phospholipases | 2002 |
Differential coupling of m-cholinoceptors to Gi/Go-proteins in failing human myocardium.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Diphosphate Ribose; Adult; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Humans; Immunoblotting; Light; Male; Middle Aged; Myocardium; Pertussis Toxin; Precipitin Tests; Receptors, Muscarinic; RNA, Messenger; Time Factors; Tissue Distribution | 2003 |
Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Animals; Aristolochic Acids; Bridged-Ring Compounds; Caffeine; Calcium; Carbachol; Diglycerides; Estrenes; Guanosine Triphosphate; Guinea Pigs; Ileum; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoenzymes; Isoproterenol; Male; Membrane Potentials; Muscle, Smooth; Norbornanes; Patch-Clamp Techniques; Phospholipase C beta; Phospholipases A; Pyrrolidinones; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Ryanodine; Thiocarbamates; Thiones; Type C Phospholipases | 2004 |
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.
Topics: Animals; Carbachol; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Mice; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; PC12 Cells; Phosphatidylinositol 3-Kinases; Phylogeny; Protein Transport; Proto-Oncogene Proteins c-raf; Rats; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Receptors, Thyrotropin; RNA, Messenger; Signal Transduction | 2004 |
Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.
Topics: ADP Ribose Transferases; Alkaloids; Amides; Animals; Bacterial Toxins; Benzophenanthridines; Botulinum Toxins; Calcium; Carbachol; Cell Membrane Permeability; Colon, Ascending; Colon, Descending; Escin; Guanosine Triphosphate; Hemolysin Proteins; Intracellular Signaling Peptides and Proteins; Japan; Male; Muscle Contraction; Myocytes, Smooth Muscle; Peptide Fragments; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; rho-Associated Kinases; Tritium; Type C Phospholipases | 2004 |
Partial bladder outlet obstruction abolishes the receptor- and G protein-dependent increase in calcium sensitivity in rabbit bladder smooth muscle.
Topics: Animals; Calcium; Carbachol; Cholinergic Agonists; GTP-Binding Proteins; Guanosine Triphosphate; Male; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Protein Kinase C; Rabbits; Signal Transduction; Urinary Bladder; Urinary Bladder Neck Obstruction | 2004 |
Decrease in GTP-sensitive high affinity agonist binding of muscarinic acetylcholine receptors in autopsied brains of dementia with Lewy bodies and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Autopsy; Binding, Competitive; Brain; Carbachol; Cholinergic Agonists; Female; Guanosine Triphosphate; Humans; Lewy Body Disease; Male; Middle Aged; Muscarinic Antagonists; Postmortem Changes; Quinuclidinyl Benzilate; Receptors, Muscarinic | 2004 |
A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.
Topics: Alkaloids; Amides; Animals; Benzophenanthridines; Calcium; Carbachol; Carcinogens; Cholinergic Agonists; Colon; Dose-Response Relationship, Drug; Guanosine Triphosphate; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic | 2007 |
Intracellular calcium stores in beta-escin skinned rat and guinea-pig bladders.
Topics: Animals; Caffeine; Calcium; Calmodulin; Carbachol; Cecum; Escin; Guanosine Triphosphate; Guinea Pigs; Heparin; Inositol Phosphates; Male; Muscle Contraction; Procaine; Rats; Rats, Wistar; Ryanodine; Urinary Bladder | 2007 |
Receptor-coupling properties of the invertebrate visual guanine nucleotide binding protein iGqalpha.
Topics: Amino Acid Sequence; Animals; Carbachol; Cell Line; Enzyme Activation; Eye Proteins; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine Triphosphate; Humans; Hydrolysis; Loligo; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Mutant Proteins; Receptor, Muscarinic M1; Receptors, Adrenergic, alpha-1; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Type C Phospholipases | 2007 |
Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.
Topics: Animals; Blotting, Western; Carbachol; Cells, Cultured; Cholinergic Agonists; Female; Guanosine Triphosphate; Immunoprecipitation; Isoenzymes; Lacrimal Apparatus; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Mutation; Protein Binding; Protein Transport; rab3 GTP-Binding Proteins; Rabbits; Receptors, Polymeric Immunoglobulin; Recombinant Proteins; Secretory Component; Secretory Vesicles; Time Factors; Transduction, Genetic | 2008 |
Muscarinic receptor subtypes mediating Ca2+ sensitization of intestinal smooth muscle contraction: studies with receptor knockout mice.
Topics: Animals; Calcium; Carbachol; Female; Guanosine Triphosphate; Ileum; Intestines; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic | 2010 |
Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agonists; Guanosine Triphosphate; Intestines; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Phosphoproteins; Phosphorylation; Potassium; Protein Kinase C; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2011 |