carbachol has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 194 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (11.34) | 18.7374 |
| 1990's | 124 (63.92) | 18.2507 |
| 2000's | 40 (20.62) | 29.6817 |
| 2010's | 8 (4.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Claro, E; Fain, JN; Wallace, MA | 2 |
| Fain, JN; Lee, HM | 1 |
| Ambudkar, IS; Baum, BJ; Hiramatsu, Y; Horn, VJ | 1 |
| Candura, SM; Costa, LG; Manzo, L | 1 |
| Aragay, AM; Katz, A; Simon, MI | 1 |
| Bado, A; Cherifi, Y; Le Romancer, M; Lewin, MJ; Pigeon, C; Reyl-Desmars, F | 1 |
| Candura, SM; Castoldi, AF; Costa, LG; Manzo, L | 2 |
| Benhamou, M; Gutkind, JS; Robbins, KC; Siraganian, RP; Stephan, V | 1 |
| Olianas, MC; Onali, P | 5 |
| Gadsby, DC; Horie, M; Hwang, TC; Nairn, AC | 1 |
| Higashijima, T; Mukai, H; Munekata, E | 1 |
| Bali, JP; Cros, G; Serrano, JJ; Soulié, ML | 1 |
| Haga, T; Shiozaki, K | 1 |
| Chidiac, P; Wells, JW | 1 |
| Kawai, M; Komori, S; Ohashi, H; Takewaki, T | 1 |
| Hilf, G; Jakobs, KH | 1 |
| Hilf, G; Jakobs, KH; Kupprion, C; Wieland, T | 1 |
| Jope, RS; Song, L | 1 |
| Danilenko, MP; Panchenko, MP; Tkachuk, VA; Turmukhambetova, VC; Yesirev, OV | 1 |
| Baker, HJ; Claro, E; Fain, JN; Nair, BG; Patel, TB; Shanker, G; Wallace, MA | 1 |
| Krnjević, K; Xu, Y | 1 |
| Ammälä, C; Berggren, PO; Bokvist, K; Juntti-Berggren, L; Kindmark, H; Larsson, O; Rorsman, P | 1 |
| Gerschenfeld, HM; Paupardin-Tritsch, D; Yakel, JL | 1 |
| Hisayama, T; Kiuchi, Y; Kumagai, N; Takayanagi, I | 1 |
| Golly, F; Larocca, JN; Ledeen, RW | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Evans, T; Ho, YK; Okabe, K; Yatani, A | 1 |
| Barnett, JV; Galper, JB; Griendling, KK; Lassegue, B; Shamah, SM | 1 |
| Li, PP; Sibony, D; Warsh, JJ | 1 |
| Carter, HR; Fain, JN; Wallace, MA | 1 |
| Danilenko, MP; Panchenko, MP; Tkachuk, VA; Yesirev, OV | 1 |
| Claro, E; Wallace, MA | 1 |
| Cooke, AM; Nahorski, SR; Potter, BV; Wojcikiewicz, RJ | 1 |
| Challiss, RA; Nahorski, SR; Safrany, ST; Strupish, J; Wojcikiewicz, RJ | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Sekura, RD; Yatani, A | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Hamm, H; Mazzoni, MR; Yatani, A | 1 |
| Kolb, HA; Somogyi, R | 2 |
| Gierschik, P; Hilf, G; Jakobs, KH | 1 |
| Burke, DN; Fleming, N; Sliwinski-Lis, E | 1 |
| Nahorski, SR; Wojcikiewicz, RJ | 1 |
| Claro, E; Garcia, A; Picatoste, F | 1 |
| Claro, E; Fain, JN; Lee, HM; Wallace, MA | 1 |
| Ashkenazi, A; Capon, DJ; Peralta, EG; Peterson, GL; Ramachandran, J; Schimerlik, MI; Winslow, JW | 1 |
| Brown, JH; Goldstein, D; Jones, LG | 1 |
| Costa, E; Fadda, E; Nicoletti, F; Wroblewski, JT | 1 |
| Chiu, AS; Li, PP; Warsh, JJ | 1 |
| Merritt, JE; Putney, JW; Rubin, RP; Taylor, CW | 2 |
| Blachier, F; Malaisse, WJ | 1 |
| Haga, K; Haga, T; Ichiyama, A; Katada, T; Kurose, H; Ui, M | 1 |
| Kahler, KR; Schimerlik, MI; Tota, MR | 1 |
| Banfic, H; Eckhardt, L; Schnefel, S; Schultz, G; Schulz, I | 1 |
| Bolton, TB; Lim, SP | 1 |
| Hokins, LE; MacDonald, MJ; Mertz, RJ; Rana, RS; Sekar, MC | 1 |
| Brown, JH; Orellana, S; Solski, PA | 1 |
| Ahn, SC; Kim, KW; Kim, SJ; So, I | 3 |
| Caspary, WF; Piiper, A; Stein, J; Stryjek-Kaminska, D; Zeuzem, S | 1 |
| Andrade, R | 1 |
| Hescheler, J | 1 |
| Yatani, A | 1 |
| Bolton, TB; Zholos, AV | 2 |
| Ambudkar, IS; Baum, BJ; Roth, GS; Sawaki, K | 1 |
| Tanabe, T; Yassin, M; Zong, S | 2 |
| Garfield, RE; Izumi, H | 1 |
| Bolton, TB; Miyazaki, H; Prestwich, SA | 1 |
| Bienek, C; Fasselt, B; Jakobs, KH; Rümenapp, U; Schmidt, M; van Koppen, CJ; Wieland, T | 1 |
| Ferrari-DiLeo, G; Flynn, DD; Mash, DC | 1 |
| Depoortere, I; Peeters, TL | 1 |
| Itagaki, M; Komori, S; Nagasaki, M; Ohashi, H | 1 |
| Bergsten, P; Berts, A; Grapengiesser, E; Gylfe, E; Hellman, B; Ling, Z; Lund, PE; Pipeleers, DG; Tengholm, A | 1 |
| Gilbert, JC; Mubagwa, K; Pappano, AJ | 1 |
| Ambudkar, IS; Baum, BJ; Sawaki, K | 1 |
| Abdel-Latif, AA; Akhtar, RA; Zhou, CJ | 1 |
| Kwiatkowska, K; Muallem, S; Xu, X; Yin, HL | 1 |
| Haga, T; Kameyama, K; Kato, H; Kato, M; Kikkawa, U; Nakamura, F; Nukada, T; Takenawa, T | 1 |
| Friedman, E; Wang, HY | 1 |
| Haga, K; Haga, T; Kameyama, K; Moro, O; Sadée, W | 1 |
| Emala, CW; Hirshman, CA; Jacoby, DB; Levine, MA; Proud, D; Yang, J | 1 |
| Gylfe, E; Lund, PE | 1 |
| Baba, A; Ishibashi, T; Kitanaka, J | 1 |
| Capito, K; Hedeskov, CJ; Kardasz, AM; Thams, P | 2 |
| Eichberg, J; Mathew, J | 1 |
| Bombien, E; Homann, D; Jakobs, KH; Offermanns, S; Sandmann, J; Schultz, G; Spicher, K; Wieland, T | 1 |
| Böhm, M; Erdmann, E; Gierschik, P; Schwinger, RH; Uhlmann, R | 1 |
| Green, MA; Li, PP; Sibony, D; Warsh, JJ | 1 |
| Chavkin, C; Dascal, N; DiMagno, L; Gaveriaux-Ruff, C; Kieffer, BL; Labarca, C; Lim, NF; Schreibmayer, W; Trollinger, D; Wang, W | 1 |
| Satoh, H; Sperelakis, N | 2 |
| Eberle-Wang, K; Friedman, E; Simansky, KJ; Wang, HY | 1 |
| Fain, JN; Sallés, J; Wallace, MA | 1 |
| Bolton, TB; Kawai, M; Komori, S; Ohashi, H; Pacaud, P | 1 |
| Jope, RS; Powers, R; Song, L | 1 |
| Belton, CM; Fatherazi, S; Herrington, J; Izutsu, KT; Oda, D; Wellner, RB | 1 |
| Kamm, KE; Kubota, Y; Stull, JT; Tang, DC | 1 |
| Raffaniello, RD; Raufman, JP | 1 |
| Ammälä, C; Berggren, PO; Bokvist, K; Larsson, O; Rorsman, P | 1 |
| Bas, N; Garcia, A | 1 |
| Browne, JP; Eccleston, JF; Gong, MC; Hall, A; Iizuka, K; Kobayashi, S; Nixon, G; Somlyo, AP; Somlyo, AV; Sugai, M | 1 |
| Jope, RS; Kish, SJ; Li, PP; Pacheco, MA; Song, L; Warsh, JJ; Young, LT | 1 |
| Burford, NT; Nahorski, SR | 1 |
| Challiss, RA; Nahorski, SR; Stuart, JA; Willars, GB | 1 |
| Bian, K; Bukoski, RD; Garfield, RE; Izumi, H | 1 |
| Baker, SP; Belardinelli, L; Ruble, J; Scammells, PJ; Shryock, JC; Srinivas, M | 1 |
| Ayyagari, PV; Crews, FT; Gerber, M; Joseph, JA; Narang, N | 1 |
| Herrmann, K; Verspohl, EJ | 1 |
| Schmid, A; Schulz, I | 1 |
| Gong, MC; Jensen, PE; Somlyo, AP; Somlyo, AV | 1 |
| Litosch, I | 1 |
| Aktories, K; Just, I; Otto, B; Pfitzer, G; Steusloff, A | 1 |
| Belardinelli, L; Song, Y; Srinivas, M | 1 |
| Burford, NT; Lameh, J; Sadée, W; Shockley, MS | 1 |
| Harrell, LE; Kolasa, K; Parsons, DS | 2 |
| Hussein, B; Jakobs, KH; Keller, J; Rümenapp, U; Schmidt, M | 1 |
| DeMuro, R; Duffey, ME; Izu, L; Li, M | 1 |
| Alonso, A; Bayon, Y; Garcia-Sancho, J; Hernandez, M; Leslie, C; Nieto, ML; Nuñez, L; Sanchez Crespo, M | 1 |
| Grabsch, H; Hescheler, J; Mehrke, G; Pereverzev, A; Schneider, T | 1 |
| Chidiac, P; Green, MA; Wells, JW | 1 |
| Dobashi, K; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Suzuki, H; Yoshii, A | 1 |
| Felder, CC; Rojas, E; Singer-Lahat, D | 1 |
| Cario-Toumaniantz, C; Chardin, P; Loirand, G; Pacaud, P | 2 |
| Abdel-Latif, AA; Akhtar, RA; Ding, KH; Husain, S; Isales, CM | 1 |
| Ayyagari, PV; Crews, FT; Gerber, M; Joseph, JA | 1 |
| Batty, IH; Currie, RA; Downes, CP | 1 |
| Inoue, R; Ito, Y; Yamada, K; Yanagida, H | 1 |
| Jun, JY; Kang, TM; Kim, KW; Kim, SJ; Kim, YC; Sim, JH; So, I; Suh, SH | 1 |
| Baghdoyan, HA; Capece, ML; Lydic, R | 1 |
| Bhullar, RP; Fleming, N; Li, L; Mellow, L | 1 |
| Giovannucci, DR; Stuenkel, EL; Yule, DI | 1 |
| Haga, T; Kameyama, K; Tsuga, H | 1 |
| Haga, T; Jakubík, J; Tucek, S | 1 |
| Ha, JH; Kang, JS; Koh, HC; Lee, CH; Min, CK; Shin, IC | 1 |
| Dobashi, K; Harada, T; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Eschenhagen, T; Korth, M; Wang, GX; Zhou, XB | 1 |
| Azpiazu, I; Cruzblanca, H; Gautam, N; Li, P; Linder, M; Zhuo, M | 1 |
| Bolton, TB; Philyppov, IB; Shuba, MF; Tsytsyura, YD; Zholos, AV | 1 |
| Balligand, JL; Dessy, C; Feron, O; Kelly, RA | 1 |
| Clancy-Keen, J; Emala, CW; Hirshman, CA | 1 |
| Adams, B; Melliti, K; Meza, U | 1 |
| Adem, A; Karlsson, E; Maullu, C; Mulugeta, E; Olianas, MC; Onali, P | 1 |
| Furusawa, Y; Nakaya, H; Ogura, T; Tamagawa, M; Uemura, H | 1 |
| Armstrong, DL; Wang, D | 1 |
| Akahane, S; Anabuki, J; Hayakawa, K; Hori, M; Karaki, H; Ozaki, H | 1 |
| Culp, DJ; Latchney, LR; Luo, W | 1 |
| Adams, BA; Melliti, K; Meza, U | 1 |
| Callado, LF; Garro, MA; López de Jesús, M; Meana, JJ; Ruíz de Azúa, I; Sallés, J | 1 |
| Driscoll, P; Escorihuela, RM; Fernández-Teruel, A; Goñi, O; López de Jesús, M; Sallés, J; Tobeña, A | 1 |
| Boyett, MR; Shui, Z; Yamanushi, TT | 1 |
| Brkic-Koric, D; Pfitzer, G; Sonntag-Bensch, D | 1 |
| Amana, IJ; Mosser, VA; Schimerlik, MI | 1 |
| Azpiazu, I; Gautam, N | 1 |
| Baghdoyan, HA; Demarco, GJ; Lydic, R | 2 |
| Hermans, E; Maloteaux, JM; Peeters, M | 1 |
| Arner, A; Bonnevier, J; Fässler, R; Somlyo, AP; Somlyo, AV | 1 |
| Dobashi, K; Endou, K; Iizuka, K; Ishizuka, T; Mori, M; Nakazawa, T; Tsukagoshi, H; Yoshii, A | 1 |
| Arima, D; Komori, S; Matsuyama, H; Nishimura, M; Okamoto, H; Suzuki, M; Unno, T; Yan, HD | 1 |
| Baghdoyan, HA; Demarco, GJ; Douglas, CL; Lydic, R | 1 |
| Fernández-López, A; Mostany, R; Paniagua, MA; Pérez, CC; Pilar-Cuéllar, F | 1 |
| Adamczyk, A; Jesko, H; Strosznajder, RP | 2 |
| Crossland, N; Dean, B; Keriakous, D; Scarr, E | 1 |
| Kim, BJ; Kim, KW; Kim, MT; Kwon, SC; Lee, JH; So, I; Yang, DK; Yeon, DS | 1 |
| Baker, OJ; Camden, JM; Erb, L; Ratchford, AM; Seye, CI; Weisman, GA | 1 |
| Dolezal, V; El-Fakahany, EE; Jakubík, J | 1 |
| Chapple, CR; Chess-Williams, R; McKay, NG; Sellers, DJ; Stevens, LA | 1 |
| Bolton, TB; Dresviannikov, AV; Zholos, AV | 1 |
| Kitazawa, T; Komori, S; Nishimura, M; Sakamoto, T; Taneike, T; Unno, T; Wess, J; Yamada, M | 1 |
| Gao, L; Huang, X; Kim, YC; Li, CH; Li, XL; Piao, LH; Xing, DG; Xu, WX; Zhang, Y | 1 |
| Baghdoyan, HA; Gozal, D; Hambrecht, VS; Lydic, R; Row, BW; Vlisides, PE | 1 |
| Bowman, MR; Chen, H; Deng, B; Goldman, S; Kasaian, M; Macleod, C; Mason, L; Williams, C; Wolf, S | 1 |
| Nakaya, H; Nishida, A; Ogura, T; Reien, Y; Tamagawa, M; Uemura, H; Yabana, H | 1 |
| Jeon, JH; Kim, BJ; Kim, SJ; So, I | 1 |
| Abraham, G; Hajek, P; Ungemach, FR | 1 |
| Nobles, M; Sebastian, S; Tinker, A | 1 |
| Bayguinov, O; Dwyer, L; Kim, H; Koh, SD; Marklew, A; Sanders, KM | 1 |
| Hong, C; Jeon, JH; Jeon, JP; Kim, BJ; Kim, HJ; Kim, J; Kim, SJ; Kim, SY; So, I; Suh, CK; Sung, TS | 1 |
| Baamonde, C; Dierssen, M; Flórez, J; Martínez-Cué, C | 1 |
| Doležal, V; El-Fakahany, EE; Jakubík, J; Janíčková, H; Randáková, A | 1 |
| Odagaki, Y; Toyoshima, R | 1 |
| Kinoshita, M; Odagaki, Y; Toyoshima, R | 2 |
194 other study(ies) available for carbachol and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Concerted CMP-dependent [3H]inositol labeling of phosphoinositides and agonist activation of phospholipase C in rat brain cortical membranes.
Topics: Animals; Carbachol; Cell Membrane; Cerebral Cortex; Cytidine Monophosphate; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Inositol; Phosphatidylinositols; Rats; Tritium; Type C Phospholipases | 1992 |
Magnesium-dependent inhibition of agonist-stimulated phosphoinositide breakdown in rat cortical slices by excitatory amino acids.
Topics: Amino Acids; Animals; Calcium; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Magnesium; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Characterization of polyphosphoinositide-specific phospholipase C in rat parotid gland membranes.
Topics: Animals; Calcium; Carbachol; Cell Membrane; Chromatography, High Pressure Liquid; Cytosol; Electrophoresis, Polyacrylamide Gel; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Immunoblotting; Inositol Phosphates; Kinetics; Male; Molecular Weight; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Thionucleotides | 1992 |
Inhibition of muscarinic receptor- and G-protein-dependent phosphoinositide metabolism in cerebrocortical membranes from neonatal rats by ethanol.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sodium Fluoride | 1992 |
The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells.
Topics: Animals; Antibodies; Carbachol; Cell Line; Cell Membrane; DNA; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Macromolecular Substances; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pituitary Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1992 |
Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1.
Topics: Binding Sites; Carbachol; Cholera Toxin; Chromatography, Affinity; Chromatography, Gel; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Antagonists; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Methylhistamines; Molecular Weight; Phosphatidylinositols; Piperidines; Receptors, Histamine; Receptors, Histamine H3; Stomach Neoplasms; Tumor Cells, Cultured | 1992 |
Guanine nucleotide- and muscarinic agonist-dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats.
Topics: Aging; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Chlorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Nerve Tissue Proteins; Neurotransmitter Agents; Phosphatidylinositols; Rats; Receptors, Muscarinic; Sodium Fluoride; Synaptosomes | 1992 |
Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.
Topics: 3T3 Cells; Animals; Antigens, Differentiation, B-Lymphocyte; Carbachol; Cell Line; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoglobulin E; Inositol Phosphates; Isoflavones; Kinetics; Leukemia, Basophilic, Acute; Mice; Models, Biological; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fc; Receptors, IgE; Receptors, Muscarinic; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1992 |
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Bacterial Toxins; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Neurotransmitter Agents; Olfactory Bulb; Parasympathomimetics; Rats | 1992 |
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.
Topics: Acetylcholine; Adenylate Cyclase Toxin; Adrenergic beta-Agonists; Animals; Carbachol; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Histamine; Ion Channels; Isoproterenol; Membrane Proteins; Myocardium; Pertussis Toxin; Phosphorylation; Propranolol; Receptors, Adrenergic, beta; Receptors, Muscarinic; Time Factors; Virulence Factors, Bordetella | 1992 |
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Carbachol; Cattle; Cell Line; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Insecta; Kinetics; Macromolecular Substances; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Receptors, Adrenergic, beta; Receptors, Muscarinic; Structure-Activity Relationship; Substance P; Transfection; Turkeys | 1992 |
Impairment of contractile response to carbachol and muscarinic receptor coupling in gastric antral smooth muscle cells isolated from diabetic streptozotocin-treated rats and db/db mice.
Topics: Animals; Carbachol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Erythromycin; Female; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pyloric Antrum; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Streptozocin | 1992 |
Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins.
Topics: Animals; Binding, Competitive; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; In Vitro Techniques; Magnesium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Swine | 1992 |
Effects of adenyl nucleotides and carbachol on cooperative interactions among G proteins.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Binding Sites; Carbachol; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mesocricetus | 1992 |
GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea-pig ileal muscle.
Topics: Animals; Carbachol; Culture Techniques; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Histamine; Ion Channel Gating; Male; Membrane Potentials; Muscle, Smooth; Pertussis Toxin; Potassium; Virulence Factors, Bordetella | 1992 |
Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes.
Topics: Acetylcholinesterase; Animals; Atropine; Biotransformation; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Magnesium; Membranes; Muscarinic Antagonists; Myocardium; Protein Binding; Receptors, Muscarinic; Swine | 1992 |
Dissociation of guanosine 5'-[gamma-thio]triphosphate from guanine-nucleotide-binding regulatory proteins in native cardiac membranes. Regulation by nucleotides and muscarinic acetylcholine receptors.
Topics: Animals; Autoradiography; Carbachol; Cations, Divalent; Chromatography, Thin Layer; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Magnesium; Myocardium; Nucleotides; Receptors, Muscarinic; Swine | 1992 |
Chronic lithium treatment impairs phosphatidylinositol hydrolysis in membranes from rat brain regions.
Topics: Animals; Brain; Carbachol; Cell Membrane; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hydrolysis; Lithium; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Sodium Fluoride; Tritium | 1992 |
Na(+)-K(+)-ATPase-G protein coupling in myocardial sarcolemma: separation and reconstitution.
Topics: Animals; Carbachol; Cholic Acids; Chromatography, Gel; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Myocardium; Osmolar Concentration; Ouabain; Rabbits; Sarcolemma; Sodium-Potassium-Exchanging ATPase; Solubility | 1991 |
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Topics: Adenylyl Cyclases; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Carbachol; Cat Diseases; Cats; Cell Membrane; Cerebral Cortex; Chlorides; Colforsin; G(M1) Ganglioside; Gangliosidoses; Gangliosidosis, GM1; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Reference Values; Sodium Fluoride | 1991 |
Mechanisms underlying anoxic hyperpolarization of hippocampal neurons.
Topics: Action Potentials; Animals; Carbachol; Chlorides; Dantrolene; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypoxia; In Vitro Techniques; Ion Channels; Neurons; Potassium Channels; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1990 |
Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
Topics: Animals; Bucladesine; Calcium; Carbachol; Cells, Cultured; Charybdotoxin; Cobalt; Electric Conductivity; Evoked Potentials; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Muscarinic enhancement of the voltage-dependent calcium current in an identified snail neuron.
Topics: Action Potentials; Animals; Biological Transport, Active; Calcium Channels; Carbachol; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Helix, Snails; Neurons; Receptors, Muscarinic; Signal Transduction | 1991 |
Guanosine 5'-triphosphate converts some populations of propylbenzilylcholine mustard-sensitive muscarinic cholinoceptor sites to sites resistant to the drug in intestinal smooth muscle.
Topics: Alkylation; Animals; Carbachol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Kinetics; Membranes; Muscle, Smooth; Propylbenzilylcholine Mustard; Proteins; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1991 |
Interaction of aluminum ions with phosphoinositide metabolism in rat cerebral cortical membranes.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Carbachol; Cell Membrane; Cerebral Cortex; Chlorides; Drug Synergism; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Male; Muscarinic Antagonists; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sodium Fluoride | 1991 |
Phosphoinositide breakdown in isolated myelin is stimulated by GTP analogues and calcium.
Topics: Animals; Calcium; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol Phosphates; Myelin Proteins; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Second Messenger Systems | 1990 |
Beta gamma dimers of G proteins inhibit atrial muscarinic K+ channels.
Topics: Acetylcholine; Animals; Atrial Function; Carbachol; Erythrocytes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; Humans; In Vitro Techniques; Kinetics; Macromolecular Substances; Potassium Channels; Protein Multimerization; Thionucleotides | 1990 |
Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling.
Topics: Animals; Carbachol; Cells, Cultured; Chick Embryo; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart Atria; Heart Ventricles; Inositol Phosphates; Kinetics; Myocardium; Pertussis Toxin; Receptors, Muscarinic; Time Factors; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Guanosine 5'-O-thiotriphosphate and sodium fluoride activate polyphosphoinositide hydrolysis in rat cortical membranes by distinct mechanisms.
Topics: Animals; Biomechanical Phenomena; Calcium; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Membranes; Phosphatidylinositols; Rats; Sodium Fluoride; Thionucleotides | 1990 |
Dual effect of fluoride on phosphoinositide metabolism in rat brain cortex. Stimulation of phospholipase C and inhibition of polyphosphoinositide synthesis.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Carbachol; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Rats; Sodium Fluoride; Thionucleotides; Type C Phospholipases | 1990 |
Activation of phospholipase C in rabbit brain membranes by carbachol in the presence of GTP gamma S; effects of biological detergents.
Topics: Animals; Brain; Carbachol; Cell Membrane; Detergents; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rabbits; Thionucleotides; Type C Phospholipases; Uncoupling Agents | 1990 |
Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma.
Topics: 4-Nitrophenylphosphatase; Animals; Carbachol; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Myocardium; Ouabain; Pertussis Toxin; Potassium; Rabbits; Receptors, Muscarinic; Sarcolemma; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Swine; Virulence Factors, Bordetella | 1990 |
Comparison of serotoninergic to muscarinic cholinergic stimulation of phosphoinositide-specific phospholipase C in rat brain cortical membranes.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Ketanserin; Membranes; Parasympathomimetics; Phosphatidylinositols; Rats; Serotonin; Synaptic Transmission; Tryptamines; Type C Phospholipases | 1990 |
Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Neuroblastoma; Organothiophosphorus Compounds | 1990 |
Coupling of muscarinic receptors to the mobilization of intracellular Ca2+ stores in permeabilized SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Calcium Radioisotopes; Carbachol; Cell Line; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Kinetics; Neuroblastoma; Receptors, Muscarinic | 1990 |
Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes.
Topics: Animals; Carbachol; Cell Membrane; Clone Cells; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channels; Membrane Potentials; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Rats; Receptors, Muscarinic; Somatostatin; Thionucleotides | 1987 |
A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels.
Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Atrial Function; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Ion Channels; Myocardium; Potassium; Receptors, Muscarinic; Thionucleotides | 1988 |
A G-protein mediates secretagogue-induced gap junctional channel closure in pancreatic acinar cells.
Topics: Animals; Carbachol; Cyclohexanones; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intercellular Junctions; Ion Channels; Kinetics; Lipase; Male; Mice; Mice, Inbred Strains; Pancreas; Thionucleotides | 1989 |
Possible involvement of a G-protein in carbamylcholine-induced gap junction closure.
Topics: Acetylcholine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Carbachol; Diglycerides; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intercellular Junctions; Lacrimal Apparatus; Membrane Potentials; Protein Kinase C; Rats; Thionucleotides; Type C Phospholipases | 1989 |
Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes.
Topics: Animals; Carbachol; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; Kinetics; Myocardium; NAD; Pertussis Toxin; Receptors, Muscarinic; Swine; Thionucleotides; Virulence Factors, Bordetella | 1989 |
G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland.
Topics: Adenylate Cyclase Toxin; Animals; Calcium; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoproterenol; Kinetics; Mucous Membrane; Pertussis Toxin; Phosphatidylinositols; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland; Thionucleotides; Virulence Factors, Bordetella | 1989 |
Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan.
Topics: Bee Venoms; Calcium; Carbachol; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Neuroblastoma; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Thionucleotides; Tumor Cells, Cultured; Type C Phospholipases; Wasp Venoms | 1989 |
Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes.
Topics: Aluminum; Animals; Carbachol; Cerebral Cortex; Enzyme Activation; Fluorine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Hydrolysis; Male; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Thionucleotides | 1989 |
Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbachol; Cell Membrane; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Substrate Specificity; Thionucleotides; Type C Phospholipases | 1989 |
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Cell Line; Cricetinae; Cyclic AMP; Gene Expression Regulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Receptors, Muscarinic; Recombinant Proteins; Thionucleotides; Virulence Factors, Bordetella | 1987 |
Guanine nucleotide-dependent inositol trisphosphate formation in chick heart cells.
Topics: Animals; Carbachol; Cells, Cultured; Chick Embryo; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Myocardium; Phosphatidylinositols; Sugar Phosphates; Thionucleotides; Type C Phospholipases | 1988 |
Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells.
Topics: Animals; Carbachol; Carrier Proteins; Cells, Cultured; Cerebellum; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Pertussis Toxin; Phospholipids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Thionucleotides; Virulence Factors, Bordetella | 1988 |
G-protein involvement in central-nervous-system muscarinic-receptor-coupled polyphosphoinositide hydrolysis.
Topics: Animals; Carbachol; Carrier Proteins; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Inositol Phosphates; Male; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thionucleotides; Type C Phospholipases | 1988 |
A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol Phosphates; Male; Parotid Gland; Propranolol; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Sodium Fluoride; Thionucleotides; Type C Phospholipases | 1986 |
Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carbachol; Ceruletide; Ethers; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol Phosphates; Ionomycin; Ionophores; Male; Pancreas; Phosphatidylinositols; Rats; Rats, Inbred Strains; Thionucleotides; Type C Phospholipases | 1986 |
Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.
Topics: Adenoma, Islet Cell; Carbachol; Cell Line; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol Phosphates; Pancreatic Neoplasms; Thionucleotides; Type C Phospholipases | 1987 |
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
Topics: Adenylate Cyclase Toxin; Animals; Binding, Competitive; Brain; Carbachol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liposomes; Magnesium; Pertussis Toxin; Phospholipids; Rats; Receptors, Muscarinic; Scopolamine; Swine; Thionucleotides; Virulence Factors, Bordetella | 1986 |
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
Topics: Adenosine Diphosphate Ribose; Animals; Carbachol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Heart Atria; Kinetics; Mathematics; Myocardium; Receptors, Muscarinic; Swine; Thionucleotides | 1987 |
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate Ribose; Animals; Carbachol; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Male; Pancreas; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Receptors, Cholinergic; Sincalide; Thionucleotides; Type C Phospholipases; Vasoactive Intestinal Peptide | 1988 |
A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.
Topics: Animals; Calcium; Carbachol; Dialysis; Egtazic Acid; Evoked Potentials; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intestine, Small; Iontophoresis; Muscle, Smooth; Rabbits; Receptors, Muscarinic; Thionucleotides | 1988 |
Potentiation by glucose metabolites of inositol trisphosphate-induced calcium mobilization in permeabilized rat pancreatic islets.
Topics: Animals; Calcium; Carbachol; Cell Membrane Permeability; Diphosphoglyceric Acids; Fructosediphosphates; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hexosediphosphates; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Islets of Langerhans; Rats; Saponins; Sugar Phosphates; Thionucleotides | 1987 |
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.
Topics: Bradykinin; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histamine; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Membranes; Phorbol Esters; Protein Kinase C; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Role of calmodulin in the activation of carbachol-activated cationic current in guinea-pig gastric antral myocytes.
Topics: Animals; Calmodulin; Carbachol; Electrophysiology; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Sulfonamides | 1995 |
Tyrphostins inhibit secretagogue-induced 1,4,5-IP3 production and amylase release in pancreatic acini.
Topics: Amylases; Animals; Bombesin; Carbachol; Catechols; Epidermal Growth Factor; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Nitriles; Osmolar Concentration; Pancreas; Permeability; Protein-Tyrosine Kinases; Rats; Sincalide; Tyrphostins | 1994 |
Infusion of guanine nucleotides through recording electrodes for studies on G-protein regulation of ion currents and channels.
Topics: Animals; Baclofen; Carbachol; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Ion Channels; Membrane Potentials; Microelectrodes; Pyramidal Cells; Rats; Serotonin; Thionucleotides | 1994 |
Whole-cell clamp analysis for G-protein regulation of channels.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium Channels; Carbachol; Cholera Toxin; Electrophysiology; Epinephrine; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Homeostasis; Hybrid Cells; Ion Channels; Macromolecular Substances; Neuroblastoma; Oligonucleotides, Antisense; Patch-Clamp Techniques; PC12 Cells; Potassium Channels; Rats; RNA, Messenger; Virulence Factors, Bordetella | 1994 |
Reconstitution of receptor-regulated ion channels in isolated patch membrane.
Topics: Acetylcholine; Animals; Carbachol; Cell Membrane; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Receptors, Muscarinic; Virulence Factors, Bordetella | 1994 |
Effects of divalent cations on muscarinic receptor cationic current in smooth muscle from guinea-pig small intestine.
Topics: Animals; Calcium; Carbachol; Cations, Divalent; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kinetics; Magnesium; Male; Muscarinic Agonists; Muscle, Smooth; Patch-Clamp Techniques; Receptors, Muscarinic | 1995 |
Decreased m3-muscarinic and alpha 1-adrenergic receptor stimulation of PIP2 hydrolysis in parotid gland membranes from aged rats: defect in activation of G alpha q/11.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Aging; Aluminum Compounds; Animals; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Isoenzymes; Membranes; Muscarinic Agonists; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phospholipase C beta; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Receptors, Neurotransmitter; Signal Transduction; Type C Phospholipases | 1995 |
G-protein modulation of alpha 1A (P/Q) type calcium channel expressed in GH3 cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Carbachol; Electric Conductivity; Electrophysiology; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Pertussis Toxin; Pituitary Neoplasms; Plasmids; Rats; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Relaxant effects of nitric oxide and cyclic GMP on pregnant rat uterine longitudinal smooth muscle.
Topics: Animals; Calcium; Carbachol; Cyclic GMP; Female; Guanosine 5'-O-(3-Thiotriphosphate); Methylene Blue; Muscle Relaxation; Myometrium; Nitric Oxide; Nitroprusside; Potassium Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Uterine Contraction | 1995 |
Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine.
Topics: Animals; Carbachol; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Cyclic AMP; Deoxyglucose; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Hydrolysis; Inositol Phosphates; Intestine, Small; L-Lactate Dehydrogenase; Muscle, Smooth; Phospholipids; Receptors, Muscarinic; Type C Phospholipases | 1995 |
Rapid and persistent desensitization of m3 muscarinic acetylcholine receptor-stimulated phospholipase D. Concomitant sensitization of phospholipase C.
Topics: Carbachol; Cell Line; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Muscarinic Agonists; Phospholipase D; Pilocarpine; Receptors, Muscarinic; Receptors, Purinergic; Transfection; Type C Phospholipases | 1995 |
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; Female; Frontal Lobe; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Male; Middle Aged; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Pirenzepine; Receptors, Muscarinic; Reference Values; Regression Analysis; Synaptic Membranes; Synaptosomes | 1995 |
Transduction mechanism of motilin and motilides in rabbit duodenal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Carbachol; Duodenum; Erythromycin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol; Inositol Phosphates; Motilin; Muscle, Smooth; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Signal Transduction; Tritium | 1995 |
Effect of trimebutine on contractile responses in skinned ileal smooth muscle.
Topics: Animals; Caffeine; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Escin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Receptors, Muscarinic; Trimebutine; Type C Phospholipases | 1994 |
Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells.
Topics: Adenosine Triphosphate; Adult; Awards and Prizes; Calcium; Carbachol; Cytoplasm; Diabetes Mellitus; Europe; Glucagon; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); History, 20th Century; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Models, Biological; Patch-Clamp Techniques; Signal Transduction; Societies, Medical; Sweden | 1994 |
Differential time course for desensitization to muscarinic effects on K+ and Ca2+ channels.
Topics: Acetylcholine; Animals; Calcium Channels; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Muscarine; Parasympathetic Nervous System; Potassium Channels | 1994 |
Alpha 1-adrenergic and m3-muscarinic receptor stimulation of phosphatidylinositol 4,5-bisphosphate-specific phospholipase C are independently mediated by G alpha q/11 in rat parotid gland membranes.
Topics: Animals; Carbachol; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Isoenzymes; Male; Membranes; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1995 |
Identification of phosphoinositide-specific phospholipase C-beta 1 and GTP-binding protein, Gq alpha, in bovine iris sphincter membranes: characteristics of the phospholipase and its coupling to cholinergic muscarinic receptors.
Topics: Animals; Calcium; Carbachol; Cattle; Cell Membrane; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Iris; Magnesium; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphorylation; Type C Phospholipases | 1994 |
Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.
Topics: Actins; Animals; Calcium; Carbachol; Cell Membrane Permeability; Cytoskeleton; Exocytosis; Gelsolin; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Pancreas; Polymers; Rats; Sincalide; Streptolysins; Tetradecanoylphorbol Acetate; Thymosin | 1995 |
Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system.
Topics: Animals; Baculoviridae; Brain; Carbachol; Cattle; Cell Line; Chromatography; Chromatography, Ion Exchange; Durapatite; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Receptors, Muscarinic; Recombinant Proteins; Spodoptera; Transfection; Type C Phospholipases | 1995 |
Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Biotransformation; Brain Chemistry; Carbachol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoblotting; Isoproterenol; Male; Protein Binding; Receptors, Neurotransmitter; Sulfur Radioisotopes | 1994 |
Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites.
Topics: Animals; Baculoviridae; beta-Adrenergic Receptor Kinases; Binding Sites; Carbachol; Cattle; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Mutation; Phosphorylation; Quinuclidinyl Benzilate; Receptors, Muscarinic; Spodoptera; Structure-Activity Relationship; Swine | 1994 |
Characterization of GTP-binding proteins coupled to inhibition of adenylyl cyclase in guinea pig tracheal epithelial cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atropine; Carbachol; Cell Membrane; Cells, Cultured; Cholera Toxin; Cyclic AMP; Epithelial Cells; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Kinetics; Male; Pertussis Toxin; Receptors, Muscarinic; Sodium Fluoride; Specific Pathogen-Free Organisms; Trachea; Virulence Factors, Bordetella | 1994 |
Caffeine inhibits cytoplasmic Ca2+ oscillations induced by carbachol and guanosine 5'-O-(3-thiotriphosphate) in hyperpolarized pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Carbachol; Cells, Cultured; Glucagon; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Islets of Langerhans; Mice; Mice, Obese; Potassium Channels | 1994 |
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Calcium; Carbachol; Cells, Cultured; Cerebral Cortex; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelins; Glutamates; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Norepinephrine; Phloretin; Phosphatidylinositols; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin | 1993 |
Inositol phospholipid turnover in digitonin-permeabilised dispersed mouse pancreatic islet cells.
Topics: Animals; Calcium; Carbachol; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Digitonin; Guanosine 5'-O-(3-Thiotriphosphate); Islets of Langerhans; Magnesium; Mice; Phosphatidylinositol Phosphates; Phosphatidylinositols | 1993 |
Guanosine-5'-(3-O-thio)triphosphate-mediated stimulation of phosphoinositidase C in solubilized rat peripheral nerve myelin and its alteration in streptozotocin-induced diabetes.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Atropine; Carbachol; Cholic Acid; Cholic Acids; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Myelin Sheath; Peripheral Nerves; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sciatic Nerve; Streptozocin; Thionucleotides | 1994 |
Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.
Topics: Affinity Labels; Amino Acid Sequence; Azides; Carbachol; Cells, Cultured; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Molecular Sequence Data; Pertussis Toxin; Phospholipase D; Photochemistry; Receptors, Muscarinic; Recombinant Proteins; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Coupling of M-cholinoceptors and A1 adenosine receptors in human myocardium.
Topics: Atropine; Binding, Competitive; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heart; Heart Atria; Heart Ventricles; Humans; In Vitro Techniques; Isoproterenol; Kinetics; Myocardial Contraction; Myocardium; Papillary Muscles; Phenylisopropyladenosine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Purinergic P1; Theophylline | 1994 |
Lithium modulation of phosphoinositide signaling system in rat cortex: selective effect on phorbol ester binding.
Topics: Animals; Caenorhabditis elegans Proteins; Calcium Channels; Carbachol; Carrier Proteins; Cell Membrane; Cerebral Cortex; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Lithium Chloride; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Signal Transduction; Sodium Fluoride | 1993 |
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Brain; Carbachol; Cloning, Molecular; DNA, Complementary; Evoked Potentials; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart Atria; Membrane Potentials; Molecular Sequence Data; Myocardium; Oocytes; Potassium Channels; Rats; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin; Xenopus | 1993 |
Hyperpolarization-activated inward current in embryonic chick cardiac myocytes: developmental changes and modulation by isoproterenol and carbachol.
Topics: Action Potentials; Animals; Carbachol; Cells, Cultured; Cesium; Chick Embryo; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Heart; Heart Rate; Heart Ventricles; Isoproterenol; Myocardium; Receptors, Adrenergic, beta; Temperature | 1993 |
Serotonin-induced muscle contraction in rat stomach fundus is mediated by a G alpha z-like guanine nucleotide binding protein.
Topics: Amino Acid Sequence; Animals; Carbachol; Gastric Mucosa; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Membranes; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach; Sulfur Radioisotopes | 1993 |
Modulation of the phospholipase C activity in rat brain cortical membranes by simultaneous activation of distinct monoaminergic and cholinergic muscarinic receptors.
Topics: Animals; Carbachol; Cerebral Cortex; Dopamine; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Radioligand Assay; Rats; Receptors, Dopamine D1; Receptors, Muscarinic; Receptors, Serotonin; Tryptamines; Type C Phospholipases | 1993 |
Oscillations of receptor-operated cationic current and internal calcium in single guinea-pig ileal smooth muscle cells.
Topics: Animals; Calcium; Carbachol; Egtazic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heparin; Ileum; Male; Membrane Potentials; Muscle, Smooth; Nifedipine; Receptors, Cell Surface; Ryanodine; Signal Transduction | 1993 |
Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes.
Topics: Adenosine Triphosphate; Aged; Aluminum Compounds; Brain; Calcium; Carbachol; Cell Membrane; Cycloleucine; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Hydrolysis; Male; Neurotoxins; Phosphatidylinositols; Pilocarpine; Postmortem Changes; Second Messenger Systems; Serotonin; Type C Phospholipases | 1994 |
Characteristics and regulation of a muscarinically activated K current in HSG-PA cells.
Topics: Calcium; Carbachol; Cell Line; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Oxotremorine; Parasympathomimetics; Potassium; Potassium Channel Blockers; Salivary Glands; Signal Transduction; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
GTP gamma S-induced phosphorylation of myosin light chain kinase in smooth muscle.
Topics: Animals; Calcium; Carbachol; Cattle; Cell Membrane Permeability; Escin; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Phosphorylation | 1993 |
Stimulation of phosphoinositide hydrolysis by muscarinic receptor activation in the rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Atropine; Bucladesine; Carbachol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Olfactory Bulb; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Guanine nucleotides activate multiple signaling pathways in permeabilized gastric chief cells. Evidence for GTP gamma S-induced calcium-independent pepsinogen secretion.
Topics: Alkaloids; Animals; Bacterial Proteins; Calcium; Carbachol; Cell Membrane Permeability; Cyclic AMP; Cytidine Diphosphate Diglycerides; Gastric Mucosa; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Pepsinogens; Phorbol Esters; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Streptolysins; Type C Phospholipases | 1993 |
Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells.
Topics: Animals; Apamin; Calcium; Carbachol; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Tetraethylammonium; Tetraethylammonium Compounds | 1993 |
Effect of deoxycholate on guanine-nucleotide-dependent carbachol stimulation of phosphoinositidase C in mouse brain cortical membranes.
Topics: Animals; Carbachol; Cell Membrane; Cerebral Cortex; Deoxycholic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Kinetics; Mice; Mice, Inbred Strains; Phosphoric Diester Hydrolases; Radioisotope Dilution Technique; Tritium | 1995 |
Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Anti-Arrhythmia Agents; Calcium Channels; Carbachol; Cations; Dose-Response Relationship, Drug; Electrophysiology; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ion Transport; Male; Microelectrodes; Muscle, Smooth; Potassium Channels; Quinidine; Receptors, Muscarinic; Stomach; Tetraethylammonium; Tetraethylammonium Compounds | 1995 |
Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Binding, Competitive; Carbachol; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immune Sera; Male; Muscarinic Agonists; N-Methylscopolamine; Neuropeptides; Olfactory Bulb; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives; Tritium | 1996 |
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.
Topics: Animals; Calcium; Carbachol; Cell Line; Cell Membrane Permeability; Cloning, Molecular; Endothelins; Enterotoxins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ileum; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth; Muscle, Smooth, Vascular; Pertussis Toxin; Phenylephrine; Rabbits; Recombinant Proteins; rhoA GTP-Binding Protein; Spodoptera; Staphylococcus aureus; Virulence Factors, Bordetella | 1996 |
The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Bipolar Disorder; Brain Chemistry; Carbachol; Cell Membrane; Cycloleucine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; Humans; Hydrolysis; Male; Middle Aged; Muscarinic Agonists; Neurotoxins; Phosphatidylinositols; Serotonin; Signal Transduction; Sodium Fluoride; Tritium; Type C Phospholipases | 1996 |
Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation.
Topics: Adenylyl Cyclases; Animals; Antibodies; Carbachol; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol 1,4,5-Trisphosphate; Isoproterenol; Kinetics; Muscarinic Agonists; Phosphoric Diester Hydrolases; Receptors, Muscarinic; Recombinant Proteins; Transfection | 1996 |
G-protein modulation of neuronal class E (alpha 1E) calcium channel expressed in GH3 cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Carbachol; Cell Line; Dihydropyridines; Electric Conductivity; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Pertussis Toxin; Pituitary Gland, Anterior; Rats; Somatostatin; Spider Venoms; Virulence Factors, Bordetella | 1996 |
Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Cell Line; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Lithium; N-Methylscopolamine; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Signal Transduction; Terpenes; Thapsigargin; Transfection; Tumor Cells, Cultured | 1996 |
Agonists increase the sensitivity of contractile elements for Ca++ in pregnant rat myometrium.
Topics: Animals; Calcium; Carbachol; Enzyme Inhibitors; Ethers, Cyclic; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Muscarinic Agonists; Myometrium; Okadaic Acid; Potassium; Pregnancy; Prostaglandins; Rats; Rats, Sprague-Dawley; Uterine Contraction | 1996 |
A novel irreversible antagonist of the A1-adenosine receptor.
Topics: Adenosine; Animals; Carbachol; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Isoproterenol; Kinetics; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Potassium Channels; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Theophylline; Xanthines | 1996 |
Age-related loss of cholinergic-muscarinic coupling to PLC: comparison with changes in brain regional PLC subtypes mRNA distribution.
Topics: Aging; Animals; Base Sequence; Brain; Calcium; Carbachol; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Isoenzymes; Male; Molecular Sequence Data; Oligonucleotide Probes; Organ Specificity; Phosphatidylinositols; Rats; Rats, Inbred F344; Receptors, Muscarinic; RNA, Messenger; Signal Transduction; Transcription, Genetic; Type C Phospholipases | 1996 |
Involvement of G proteins in the effect of carbachol and cholecystokinin in rat pancreatic islets.
Topics: Animals; Carbachol; Female; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pertussis Toxin; Rats; Rats, Wistar; Sincalide; Virulence Factors, Bordetella | 1996 |
Different time courses of GTP[gamma-S]-induced exocytosis and current oscillations in isolated mouse pancreatic acinar cells.
Topics: Animals; Carbachol; Digitonin; Egtazic Acid; Electric Conductivity; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Pancreas; Time Factors | 1996 |
Separate upstream and convergent downstream pathways of G-protein- and phorbol ester-mediated Ca2+ sensitization of myosin light chain phosphorylation in smooth muscle.
Topics: Animals; Calcium; Carbachol; Cell Membrane; Cytosol; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Isoenzymes; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphorylation; Portal Vein; Protein Kinase C; Rabbits; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1996 |
G-protein inhibition of phospholipase C-beta 1 in membranes: role of G-protein beta gamma subunits.
Topics: Animals; Carbachol; Cattle; Cell Membrane; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Isoenzymes; Liver; Membranes; Phenylephrine; Phospholipase C beta; Protein Conformation; Rats; Thionucleotides; Type C Phospholipases; Vasopressins | 1996 |
Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle.
Topics: Adenosine Diphosphate Ribose; Animals; Bacterial Proteins; Bacterial Toxins; Calcium; Carbachol; Cholinergic Agonists; Escin; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; Recombinant Proteins; rhoA GTP-Binding Protein | 1996 |
Stimulation of guanosine 5'-O-(3-[35S] thiotriphosphate) binding by cholinergic muscarinic receptors in membranes of rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Carbachol; Cholera Toxin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Proteins; Muscarinic Agonists; Neuropeptides; Neurotransmitter Agents; Olfactory Bulb; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sodium Chloride; Sulfur Radioisotopes; Time Factors | 1996 |
Nonspecific inhibition of adenosine-activated K+ current by glibenclamide in guinea pig atrial myocytes.
Topics: Action Potentials; Adenosine; Animals; Atrial Function; Carbachol; Electric Conductivity; Glyburide; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Myocardium; Pinacidil; Potassium; Reaction Time | 1996 |
Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.
Topics: Adenylyl Cyclases; Animals; Carbachol; CHO Cells; Cricetinae; Down-Regulation; Endocytosis; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Inositol Phosphates; Microscopy, Confocal; Muscarinic Agonists; Mutation; Receptors, Cell Surface; Receptors, Muscarinic; Signal Transduction; Subcellular Fractions; Sulfur Radioisotopes; Transfection; Type C Phospholipases | 1997 |
Effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal phospholipase C activity and G-protein function.
Topics: Adrenergic Fibers; Animals; Calcium; Carbachol; Choline O-Acetyltransferase; Cholinergic Fibers; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hydrolysis; Male; Parasympathomimetics; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Sympathectomy; Tritium; Type C Phospholipases | 1997 |
Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA.
Topics: Atropine; Biological Transport; Carbachol; Catechols; Cell Line; Cell Membrane; Cell Membrane Permeability; Cytosol; Digitonin; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoflavones; Kidney; Muscarinic Agonists; Muscarinic Antagonists; Nitriles; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, Muscarinic M3; Receptors, Muscarinic; rhoA GTP-Binding Protein; Tyrphostins; Vanadates | 1997 |
Effects of protons on muscarinic receptor cationic current in single visceral smooth muscle cells.
Topics: Animals; Carbachol; Cations; Electric Conductivity; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Hydrogen-Ion Concentration; Ions; Male; Muscarinic Agonists; Muscle, Smooth; Protons; Receptors, Muscarinic; Viscera | 1997 |
Developmental changes and modulation through G-proteins of the hyperpolarization-activated inward current in embryonic chick heart.
Topics: Animals; Calcium Channels; Carbachol; Chick Embryo; Fetal Heart; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart Rate; Isoproterenol; Time Factors | 1993 |
G proteins activate ionic conductances at multiple sites in T84 cells.
Topics: Calcium; Carbachol; Electric Conductivity; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Ions; Oscillometry; Parasympathomimetics; Potassium; Tumor Cells, Cultured | 1997 |
Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.
Topics: Arachidonic Acid; Astrocytoma; Brain Neoplasms; Calcimycin; Calcium; Carbachol; Carcinogens; Cytosol; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ionophores; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1997 |
Carbamoylcholine regulation of polyphosphoinositide synthesis and hydrolysis in cultured, dispersed, digitonin-permeabilized mouse pancreatic islet cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Carbachol; Cells, Cultured; Digitonin; Guanosine 5'-O-(3-Thiotriphosphate); Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Permeability; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Sodium Fluoride; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Receptor-mediated modulation of recombinant neuronal class E calcium channels.
Topics: Adenosine; Adenosine Triphosphate; Amino Acid Sequence; Barium; Binding Sites; Calcium; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cell Line; Cloning, Molecular; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Neurons; Pertussis Toxin; Recombinant Fusion Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Somatostatin; Thionucleotides; Transfection; Virulence Factors, Bordetella | 1997 |
Cardiac muscarinic receptors. Relationship between the G protein and multiple states of affinity.
Topics: Animals; Carbachol; Cell Membrane; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanylyl Imidodiphosphate; Mesocricetus; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1997 |
Inhibitory effect of phorbol 12,13 dibutyrate on carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.
Topics: Animals; Carbachol; Cations; Electric Conductivity; Gastric Mucosa; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ion Channels; Muscarinic Agonists; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Stomach | 1997 |
Receptor-dependent G protein-mediated Ca2+ sensitization in canine airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aluminum; Animals; Bacterial Toxins; Calcium; Calcium-Binding Proteins; Calponins; Carbachol; Cell Membrane Permeability; Dogs; Endothelin-1; Escin; Female; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; Histamine; Isometric Contraction; Male; Microfilament Proteins; Muscle, Smooth; Peptide Fragments; Phorbol 12,13-Dibutyrate; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Muscarinic; Serotonin; Thromboxane A2; Trachea | 1997 |
Impairment of muscarinic stimulation of adenylyl cyclase by heparin in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Carbachol; Colforsin; Corpus Striatum; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heparin; In Vitro Techniques; Kinetics; Male; Muscarinic Agonists; N-Methylscopolamine; Olfactory Bulb; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives | 1997 |
A9 fibroblasts transfected with the m3 muscarinic receptor clone express a Ca2+ channel activated by carbachol, GTP and GDP.
Topics: Animals; Calcium Channels; Carbachol; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Membrane Potentials; Patch-Clamp Techniques; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Thionucleotides; Transfection | 1997 |
ARF-independent inhibition of the carbachol-induced contractions by brefeldin A in intestinal smooth muscle.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Calcium Channel Blockers; Calcium Channels; Carbachol; Cyclopentanes; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Rats; Rats, Wistar | 1997 |
Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Carbachol; Cats; Cell Fractionation; Cell Membrane; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Inositol 1,4,5-Trisphosphate; Iris; Isoproterenol; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Ryanodine; Thapsigargin; Type C Phospholipases | 1997 |
Uncoupling of muscarinic cholinergic phosphoinositide signals in senescent cerebral cortical and hippocampal membranes.
Topics: Aging; Animals; Calcium; Carbachol; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hydrolysis; Male; Muscarinic Agonists; Phosphatidylinositols; Rats; Rats, Inbred F344; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1998 |
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
Topics: Astrocytoma; Carbachol; Cell Compartmentation; Cell Membrane Permeability; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol; Kinetics; Models, Biological; Phosphatidylinositol Phosphates; Phosphatidylinositols; Receptors, Muscarinic; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Postsynaptic enhancement by motilin of muscarinic receptor cation currents in duodenal smooth muscle.
Topics: Animals; Atropine; Carbachol; Duodenum; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Guanosine 5'-O-(3-Thiotriphosphate); Hormone Antagonists; Male; Motilin; Muscarinic Agonists; Muscle, Smooth; Patch-Clamp Techniques; Peptides, Cyclic; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Muscarinic; Receptors, Neuropeptide | 1998 |
Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes.
Topics: Amino Acid Sequence; Animals; Calcium; Carbachol; Cations; Diglycerides; Egtazic Acid; Electric Conductivity; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ion Channels; Male; Molecular Sequence Data; Muscle, Smooth; Parasympathomimetics; Patch-Clamp Techniques; Protein Kinase C; Stomach | 1998 |
Carbachol stimulates [35S]guanylyl 5'-(gamma-thio)-triphosphate binding in rapid eye movement sleep-related brainstem nuclei of rat.
Topics: Animals; Atropine; Autoradiography; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; Locus Coeruleus; Male; Muscarinic Agonists; Muscarinic Antagonists; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reticular Formation; Sleep, REM; Sulfur Radioisotopes | 1998 |
Activation of phospholipase D by ADP-ribosylation factor in rat submandibular acinar cells.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acids; Brefeldin A; Carbachol; Carrier Proteins; Cyclopentanes; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Estrenes; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Macrolides; Male; Membrane Lipids; Phosphatidic Acids; Phosphatidylcholines; Phosphodiesterase Inhibitors; Phospholipase D; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Pyrrolidinones; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Submandibular Gland; Time Factors; Type C Phospholipases | 1998 |
Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells.
Topics: Animals; Calcium; Carbachol; Cell Membrane; Cytoplasmic Granules; Cytosol; Exocytosis; Fluorescent Dyes; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Membrane Fusion; Membrane Potentials; Pancreas; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1998 |
Desensitization of human muscarinic acetylcholine receptor m2 subtypes is caused by their sequestration/internalization.
Topics: Animals; beta-Adrenergic Receptor Kinases; Carbachol; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Transfection | 1998 |
Effects of an agonist, allosteric modulator, and antagonist on guanosine-gamma-[35S]thiotriphosphate binding to liposomes with varying muscarinic receptor/Go protein stoichiometry.
Topics: Alcuronium; Animals; Atropine; Carbachol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Liposomes; Muscarinic Agonists; Muscarinic Antagonists; Nicotinic Antagonists; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sulfur Radioisotopes; Swine; Tritium | 1998 |
Differential coupling of G alpha q family of G-protein to muscarinic M1 receptor and neurokinin-2 receptor.
Topics: Animals; Carbachol; Cell Membrane; COS Cells; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Isoenzymes; Molecular Sequence Data; Phospholipase C beta; Protein Binding; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Neurokinin-2; Transfection; Type C Phospholipases | 1998 |
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle.
Topics: Animals; Blotting, Western; Calcium Signaling; Carbachol; Cell Membrane; Enzyme Inhibitors; Gonadal Steroid Hormones; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Isometric Contraction; Marine Toxins; Muscarinic Agonists; Muscle, Smooth; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Recombinant Proteins; rho GTP-Binding Proteins | 1999 |
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Detergents; Dose-Response Relationship, Drug; Endothelin-1; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Oxazoles; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Trachea; Type C Phospholipases | 1999 |
Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes.
Topics: Action Potentials; Animals; Antineoplastic Agents; Carbachol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Heart Ventricles; Humans; In Vitro Techniques; Male; Membrane Potentials; Mitoxantrone; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; Patch-Clamp Techniques; Potassium Channels; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Tetrodotoxin | 1999 |
A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling.
Topics: Amino Acid Sequence; Animals; Brain; Calcium; Calcium Channels; Carbachol; Cattle; Cells, Cultured; CHO Cells; Clonidine; Cricetinae; Cytoplasm; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; N-Methylscopolamine; Neurons; Oxotremorine; Peptide Fragments; Receptor, Muscarinic M4; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Receptors, Somatostatin; Signal Transduction; Spinal Cord; Superior Cervical Ganglion; Transfection | 1999 |
Voltage-dependent inhibition of the muscarinic cationic current in guinea-pig ileal cells by SK&F 96365.
Topics: Animals; Calcium Channel Blockers; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; Imidazoles; Ion Channels; Male; Membrane Potentials; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Receptors, Muscarinic | 2000 |
Effects of pertussis toxin and galpha-protein-specific antibodies on phosphoinositide hydrolysis in rat brain membranes after cholinergic denervation and hippocampal sympathetic ingrowth.
Topics: Animals; Antibodies; Antibody Specificity; Brain; Carbachol; Cell Membrane; Denervation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hydrolysis; Male; Pertussis Toxin; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 2000 |
Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling.
Topics: Animals; Carbachol; Caveolin 1; Caveolins; Cell Membrane; Cells, Cultured; Cholinergic Agonists; COS Cells; Dose-Response Relationship, Drug; Dynamins; Endothelium, Vascular; Genes, Dominant; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Immunoblotting; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Receptors, Cell Surface; Receptors, Muscarinic; Recombinant Proteins; Signal Transduction; Time Factors; Transfection | 2000 |
Decreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment.
Topics: Adenylyl Cyclases; Aluminum; Animals; Atropine; Carbachol; Cattle; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Down-Regulation; Enzyme Activation; Erythrocytes; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoblotting; Mice; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Radioligand Assay; Sodium Fluoride; Time; Trachea | 2000 |
Muscarinic stimulation of alpha1E Ca channels is selectively blocked by the effector antagonist function of RGS2 and phospholipase C-beta1.
Topics: Animals; Brain; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, R-Type; Carbachol; Cation Transport Proteins; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ion Transport; Isoenzymes; Muscarinic Agonists; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Phospholipase C beta; Rabbits; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; RGS Proteins; Signal Transduction; Staurosporine; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 2000 |
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Topics: Acetylcholine; Animals; Carbachol; Cell Membrane; CHO Cells; Cholinergic Agents; Cricetinae; Cyclic AMP; Elapid Venoms; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M1; Receptors, Muscarinic; Tritium | 2000 |
Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts.
Topics: Action Potentials; Adenosine; Animals; Atrial Fibrillation; Atrial Function; Calcium Channel Blockers; Carbachol; Cardiovascular Agents; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Membrane Potentials; Potassium Channels; Receptors, Muscarinic; Thiazepines | 2000 |
Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea-pig atrial myocytes.
Topics: Acetylcholine; Animals; Carbachol; Cholinergic Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; Myocardium; Potassium Channels; Tetraethylammonium | 2000 |
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Chickens; Enzyme Inhibitors; Female; Gene Expression; Gizzard, Avian; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Verapamil | 2000 |
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
Topics: Affinity Labels; Animals; Azides; Carbachol; Cholera Toxin; Cholinergic Agonists; Elapid Venoms; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Hydrolysis; In Vitro Techniques; Male; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphorus Radioisotopes; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Specific Pathogen-Free Organisms; Sublingual Gland; Virulence Factors, Bordetella | 2001 |
RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line.
Topics: Calcium Channels, N-Type; Carbachol; Cell Line; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Muscarinic Agonists; Pertussis Toxin; RGS Proteins; Staurosporine; Time Factors; Virulence Factors, Bordetella | 2001 |
Regulation of phospholipase Cbeta activity by muscarinic acetylcholine and 5-HT(2) receptors in crude and synaptosomal membranes from human cerebral cortex.
Topics: Adult; Carbachol; Cerebral Cortex; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; In Vitro Techniques; Isoenzymes; Male; Middle Aged; Muscarinic Agonists; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Receptors, Muscarinic; Receptors, Serotonin; Subcellular Fractions; Synaptic Membranes; Synaptosomes; Type C Phospholipases | 2001 |
Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines.
Topics: Animals; Carbachol; Cerebral Cortex; Cholinergic Agonists; Genetics, Behavioral; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Isoenzymes; Male; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Rats; Signal Transduction; Species Specificity; Tryptamines; Type C Phospholipases | 2001 |
Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels.
Topics: Acetylcholine; Animals; Animals, Newborn; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heart Atria; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Time Factors; Transfection; Trypsin | 2001 |
Thiophosphorylation-induced Ca(2+) sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Amides; Animals; Calcium; Carbachol; Drug Synergism; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Staurosporine; Sulfhydryl Compounds; Sulfur | 2001 |
Kinetic analysis of M2 muscarinic receptor activation of Gi in Sf9 insect cell membranes.
Topics: Animals; Atropine; Carbachol; Cell Line; Cell Membrane; Cholinergic Agonists; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insecta; Kinetics; Mathematics; Muscarinic Antagonists; Mutagenesis, Site-Directed; Receptor, Muscarinic M2; Receptors, Muscarinic | 2002 |
Role of G protein beta gamma complex in receptor-G protein interaction.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Escherichia coli; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Kinetics; Protein Prenylation; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; RGS Proteins; Spodoptera; Sulfur Radioisotopes; Transfection | 2002 |
Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception.
Topics: Animals; Autoradiography; Brain Stem; Carbachol; Cats; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Models, Animal; Nociceptors; Pain; Rats; Reticular Formation; Sleep; Species Specificity; Sulfur Radioisotopes; Wakefulness | 2003 |
Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum.
Topics: Amantadine; Animals; Benzazepines; Carbachol; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Memantine; Membranes; Muscarinic Agonists; Neostriatum; Rats; Rats, Wistar; Spiperone; Synaptic Transmission; Synaptosomes | 2003 |
Modulation of Ca2+ sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Carbachol; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Mice, Transgenic; Muscle, Smooth; Muscles; Nucleotides; Time Factors | 2004 |
Carbachol in the pontine reticular formation of C57BL/6J mouse decreases acetylcholine release in prefrontal cortex.
Topics: Acetylcholine; Animals; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Pons; Prefrontal Cortex; Protein Binding; Reticular Formation | 2004 |
8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bronchi; Calcium; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Serine-Threonine Kinases; Rabbits; rho-Associated Kinases; Trachea | 2004 |
Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in Guinea pig ileal smooth muscle cells.
Topics: Animals; Antibodies, Blocking; Carbachol; Cations; Diglycerides; Enzyme Inhibitors; Estrenes; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth; Potassium Channels, Calcium-Activated; Pyrrolidinones; Receptors, Muscarinic; Type C Phospholipases | 2004 |
Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing.
Topics: Acetylcholine; Animals; Autoradiography; Binding Sites; Brain Chemistry; Carbachol; Cholinergic Agonists; Electroencephalography; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Microinjections; Pons; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Respiration; Sleep; Sulfur Isotopes | 2004 |
Differential effects on [35S]GTPgammaS binding using muscarinic agonists and antagonists in the gerbil brain.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain; Brain Chemistry; Carbachol; Dose-Response Relationship, Drug; Gerbillinae; Guanosine 5'-O-(3-Thiotriphosphate); Male; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Radioligand Assay; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Sulfur Radioisotopes; Synaptic Transmission | 2005 |
Poly(ADP-ribose) polymerase-1 is a novel nuclear target for cholinergic receptor signaling in the hippocampus.
Topics: Animals; Calcium Signaling; Carbachol; Cholinergic Agonists; Diglycerides; Gallic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Male; Maleimides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction | 2005 |
No change in cortical muscarinic M2, M3 receptors or [35S]GTPgammaS binding in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Binding Sites; Carbachol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Prefrontal Cortex; Protein Binding; Radioligand Assay; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Schizophrenia; Sulfur Radioisotopes | 2006 |
Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Calcium Channels; Carbachol; Cholinergic Agonists; Enzyme Activation; Free Radicals; Gallic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Inositol 1,4,5-Trisphosphate Receptors; Male; Peptide Fragments; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Signal Transduction | 2005 |
Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.
Topics: Animals; Calmodulin; Carbachol; Cell Line; Cholinergic Agonists; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Mice; Myosin-Light-Chain Kinase; Patch-Clamp Techniques; RNA, Small Interfering; TRPC Cation Channels | 2006 |
Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland.
Topics: Adenosine Diphosphate; Animals; Blotting, Northern; Blotting, Western; Calcium; Calcium Signaling; Carbachol; Edetic Acid; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Muscarinic Agonists; Phosphorylation; Protein Binding; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reverse Transcriptase Polymerase Chain Reaction; Salivary Glands; Thionucleotides | 2006 |
Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Thiadiazoles | 2006 |
Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder.
Topics: Animals; Binding, Competitive; Carbachol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; Urinary Bladder; Urinary Incontinence | 2006 |
Muscarinic receptor-activated cationic channels in murine ileal myocytes.
Topics: Animals; Carbachol; Cholinergic Agonists; Female; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; Male; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Receptors, Muscarinic; Transient Receptor Potential Channels | 2006 |
Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells.
Topics: Animals; Carbachol; Cations; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Ion Channel Gating; Ion Channels; Jejunum; Kinetics; Membrane Potentials; Mice; Mice, Knockout; Models, Molecular; Muscarinic Agonists; Muscle, Smooth; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Protein Conformation; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Signal Transduction; Type C Phospholipases | 2007 |
Muscarinic activity modulated by C-type natriuretic peptide in gastric smooth muscles of guinea-pig stomach.
Topics: Aminoquinolines; Animals; Carbachol; Cholinergic Agonists; Cyclic GMP; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Natriuretic Peptide, C-Type; Patch-Clamp Techniques; Stomach | 2007 |
Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus.
Topics: Analgesics, Opioid; Animals; Autoradiography; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypoxia; In Vitro Techniques; Male; Oxygen; Protein Binding; Rats; Rats, Sprague-Dawley | 2007 |
CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-gamma activity.
Topics: Acetylcholine; Airway Resistance; Animals; Arginase; Carbachol; Cationic Amino Acid Transporter 2; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isometric Contraction; Isoproterenol; Lung; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phosphotransferases (Alcohol Group Acceptor); Spermine; Trachea | 2007 |
Effects of azimilide on the muscarinic acetylcholine receptor-operated K+ current and experimental atrial fibrillation in guinea-pig hearts.
Topics: Action Potentials; Animals; Atrial Fibrillation; Carbachol; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; Hydantoins; Imidazolidines; In Vitro Techniques; Muscarinic Antagonists; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Refractory Period, Electrophysiological | 2007 |
Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.
Topics: Animals; Azepines; Calmodulin; Carbachol; Cells, Cultured; Female; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; Male; Mice; Mice, Inbred ICR; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Naphthalenes; Sulfonamides; TRPC Cation Channels | 2007 |
Segment-dependent activation of muscarinic acetylcholine receptor-mediated [35S]Guanosine-5'-O-(gamma-thiotriphosphate) binding in airway tissue membranes.
Topics: Animals; Bronchi; Carbachol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Horses; In Vitro Techniques; Lung; Magnesium Chloride; Membranes; Muscarinic Agonists; Muscarinic Antagonists; Receptors, Muscarinic; Respiratory System; Sodium Chloride; Tissue Distribution; Trachea | 2009 |
HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.
Topics: Acetylcholine; Animals; Bee Venoms; Carbachol; Cell Line; Cholinergic Agonists; Female; Fluorescent Antibody Technique; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine 5'-O-(3-Thiotriphosphate); Heart Atria; Humans; Ion Channel Gating; Kinetics; Male; Mice; Myocytes, Cardiac; Patch-Clamp Techniques; Pertussis Toxin; Potassium; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Receptor, Muscarinic M2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2010 |
Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.
Topics: Amides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Carbachol; Cell Membrane; Colon; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Mice; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Pyridines; rho-Associated Kinases | 2011 |
Molecular determinants of PKA-dependent inhibition of TRPC5 channel.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Ion Channel Gating; Membrane Potentials; Mice; Muscle, Skeletal; TRPC Cation Channels | 2011 |
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Disease Models, Animal; Dopamine Agonists; Down Syndrome; Environment; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Isoproterenol; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Norepinephrine; Signal Transduction | 2011 |
Subtype differences in pre-coupling of muscarinic acetylcholine receptors.
Topics: Animals; Binding, Competitive; Carbachol; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Mutation; N-Methylscopolamine; Receptors, Muscarinic | 2011 |
Activation of Gq proteins coupled with 5-HT2 receptors in rat cerebral cortical membranes assessed by antibody-capture scintillation proximity assay/[S]GTPγS binding.
Topics: Animals; Antibodies; Biological Assay; Carbachol; Cerebral Cortex; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT2; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes | 2013 |
Functional activation of Gαq via serotonin2A (5-HT2A) and muscarinic acetylcholine M1 receptors assessed by guanosine-5׳-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding/immunoprecipitation in rat brain membranes.
Topics: Animals; Brain; Carbachol; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Immunoprecipitation; Male; Membranes; Protein Binding; Rats; Receptor, Muscarinic M1; Receptor, Serotonin, 5-HT2A; Serotonin | 2014 |
Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.
Topics: Acetylcholine; Animals; Carbachol; Cell Membrane; Cerebral Cortex; Corpus Striatum; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Protein Binding; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Stimulation, Chemical | 2014 |