carbachol has been researched along with glycerophosphoinositol 4,5-bisphosphate in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (21.33) | 18.7374 |
| 1990's | 37 (49.33) | 18.2507 |
| 2000's | 21 (28.00) | 29.6817 |
| 2010's | 1 (1.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dumont, JE; Esteves, RZ; van Sande, J | 1 |
| Abdel-Latif, AA; Akhtar, RA; Tachado, SD; Zhou, CJ | 1 |
| Ambudkar, IS; Baum, BJ; Hiramatsu, Y; Horn, VJ | 1 |
| Chung, HC; Fleming, N | 2 |
| Aragay, AM; Katz, A; Simon, MI | 1 |
| Challiss, RA; Chilvers, ER; Nahorski, SR | 1 |
| Wills-Karp, M | 1 |
| Abdel-Latif, AA; Akhtar, RA | 3 |
| Baker, HJ; Claro, E; Fain, JN; Nair, BG; Patel, TB; Shanker, G; Wallace, MA | 1 |
| Collins, SP; Roberts, ML | 1 |
| Barnes, PJ; Batty, IH; Challiss, RA; Chilvers, ER; Nahorski, SR | 1 |
| Joseph, JA; Kowatch, MA; Maki, T; Roth, GS | 1 |
| Björklund, PE; Cowburn, RF; Fowler, CJ; Garlind, A; O'Neill, C; Tiger, G; Wiehager, B | 1 |
| Fleming, N; Laniyonu, A; Sliwinski-Lis, E | 1 |
| Hung, WC; Wei, JW | 1 |
| Carter, HR; Fain, JN; Wallace, MA | 1 |
| Nahorski, SR; Wojcikiewicz, RJ | 1 |
| Claro, E; Fain, JN; Lee, HM; Wallace, MA | 1 |
| Alger, BE; McCarren, M; Pitler, TA | 1 |
| Ambudkar, IS; Baum, BJ; Horn, VJ | 1 |
| Agranoff, BW; Hajra, AK; Van Rooijen, LA | 1 |
| Roberts, ML; Tennes, KA | 1 |
| Davis, JS; Farese, RV; Larson, RE; Orchard, JL; Sabir, MA | 1 |
| Anggård, EE; Downes, CP; Irvine, RF; Letcher, AJ | 1 |
| Hoffman, PL; Luthin, GR; Moses, F; Tabakoff, B | 1 |
| Downes, CP; Hawkins, PT; Stephens, L | 1 |
| Quist, EE; Satumtira, N | 1 |
| Berrie, CP; Downes, CP; Hawkins, PT; Morris, AJ | 1 |
| Dibner, MD; Downes, CP; Hanley, MR | 1 |
| Burgess, GM; Halenda, SP; McKinney, JS; Putney, JW; Rubin, RP | 1 |
| Ambudkar, IS; Baum, BJ; Roth, GS; Sawaki, K | 1 |
| Akhtar, RA; Araki-Sasaki, K; Handa, H; Zhang, Y | 1 |
| Hildebrandt, JP | 1 |
| Dreux, C; Lods, JS; Morisset, J; Rossignol, B | 1 |
| Ferrari-DiLeo, G; Flynn, DD; Mash, DC | 1 |
| Challiss, RA; Mistry, R; Wilke, R | 1 |
| Challiss, RA; Jenkinson, S; Nahorski, SR | 1 |
| Ambudkar, IS; Baum, BJ; Sawaki, K | 1 |
| Abdel-Latif, AA; Akhtar, RA; Zhou, CJ | 1 |
| Eichberg, J; Mathew, J | 1 |
| Abdel-Latif, AA; Akhtar, RA; Wang, XL | 1 |
| Ferrari-DiLeo, G; Flynn, DD | 1 |
| Barrantes, FJ; Pediconi, MF | 1 |
| Barrett, KE; Cohn, JA; Dharmsathaphorn, K; Kachintorn, U; Traynor-Kaplan, A; Vajanaphanich, M | 1 |
| Baron, CB; Blackman, D; Coburn, RF; Pompeo, J | 1 |
| Jakobs, KH; Nehls, C; Rümenapp, U; Schmidt, M | 1 |
| Ebihara, T; Saffen, D | 1 |
| Abdel-Latif, AA; Akhtar, RA; Ding, KH; Husain, S; Isales, CM | 1 |
| Challiss, RA; Nahorski, SR; Willars, GB | 1 |
| Hammer, K; Haupenthal, S; Jakobs, KH; Lohmann, B; Nehls, MV; Schmidt, M | 1 |
| Collyn, L; Corvilain, B; Dumont, JE; van Sande, J | 1 |
| Biden, TJ; Carpenter, L; Iismaa, TP; Kerr, EA; Sims, N; Wilson, JR | 1 |
| Culp, DJ; Latchney, LR; Luo, W | 1 |
| Biden, TJ; Blewitt, M; Kelly, MM; Mitchell, CJ; Wilson, JR | 1 |
| Callado, LF; Garro, MA; López de Jesús, M; Meana, JJ; Ruíz de Azúa, I; Sallés, J | 1 |
| Driscoll, P; Escorihuela, RM; Fernández-Teruel, A; Goñi, O; López de Jesús, M; Sallés, J; Tobeña, A | 1 |
| Challiss, RA; Nahorski, SR; Nash, MS; Willars, GB; Young, KW | 1 |
| Baron, CB; Broome, R; Coburn, RF; Sul, D | 1 |
| Greene, AK; Popova, JS; Rasenick, MM; Wang, J | 1 |
| Clapham, DE; Runnels, LW; Yue, L | 1 |
| Foskett, JK; Li, Q; Mak, DO; Muallem, S; Shin, DM; Zeng, W | 1 |
| Popova, JS; Rasenick, MM | 1 |
| Dehoff, M; Kang, SH; Luo, X; Muallem, S; Nayak, SK; Ross, EM; Shin, DM; Tu, J; Worley, PF | 1 |
| Liu, B; Qin, F | 1 |
| Gamper, N; Hilgemann, DW; Li, Y; Shapiro, MS | 1 |
| Albanesi, JP; Dong, P; Feng, S; Hilgemann, DW; Lariccia, V; Lin, MJ; Shen, C; Yang, J; Yaradanakul, A; Yin, HL | 1 |
| Ho, WK; Lee, SH; Lim, A; Sohn, JW | 1 |
| Bird, GS; DeHaven, WI; Lemonnier, L; Putney, JW; Trebak, M; Wedel, BJ | 1 |
| Jeon, JH; Kim, BJ; Kim, MT; Kim, SJ; So, I | 1 |
| Hancock, J; Hobson, SA; Kelly, E; Marrion, NV; Mason, A; Oldfield, S; Randall, AD; Wynick, D | 1 |
| Mandal, M; Yan, Z | 1 |
| Balla, A; Balla, T; Gulyás, G; Hammond, GR; Hunyady, L; Tóth, DJ; Tóth, JT; Várnai, P | 1 |
75 other study(ies) available for carbachol and glycerophosphoinositol 4,5-bisphosphate
| Article | Year |
|---|---|
Nitric oxide as a signal in thyroid.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Calcium; Carbachol; Cyclic GMP; Dogs; Enzyme Activation; Guanylate Cyclase; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Signal Transduction; Thyroid Gland | 1992 |
Effects of isoproterenol and forskolin on carbachol- and fluoroaluminate-induced polyphosphoinositide hydrolysis, inositol trisphosphate production, and contraction in bovine iris sphincter smooth muscle: interaction between cAMP and IP3 second messenger
Topics: Aluminum; Animals; Carbachol; Cattle; Colforsin; Cyclic AMP; Deferoxamine; Fluorine; Hydrolysis; Inositol 1,4,5-Trisphosphate; Iris; Isoproterenol; Kinetics; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Second Messenger Systems; Sodium Fluoride | 1992 |
Characterization of polyphosphoinositide-specific phospholipase C in rat parotid gland membranes.
Topics: Animals; Calcium; Carbachol; Cell Membrane; Chromatography, High Pressure Liquid; Cytosol; Electrophoresis, Polyacrylamide Gel; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Immunoblotting; Inositol Phosphates; Kinetics; Male; Molecular Weight; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Thionucleotides | 1992 |
Arachidonic acid regulates the phosphoinositide signal transduction pathway in submandibular acinar cells.
Topics: Animals; Arachidonic Acid; Carbachol; Cells, Cultured; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Leukotrienes; Male; Mucins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Signal Transduction; Submandibular Gland | 1992 |
The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells.
Topics: Animals; Antibodies; Carbachol; Cell Line; Cell Membrane; DNA; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Macromolecular Substances; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pituitary Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1992 |
Detection of sustained mass increases in inositol 1,3,4,5-tetrakisphosphate in agonist-stimulated airway smooth muscle.
Topics: Animals; Atropine; Carbachol; Cattle; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Trachea | 1991 |
Effects of age on muscarinic agonist-induced contraction and IP accumulation in airway smooth muscle.
Topics: Aging; Animals; Carbachol; GTP-Binding Proteins; Guinea Pigs; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Sodium Fluoride; Trachea; Virulence Factors, Bordetella | 1991 |
The effect of M & B 22948 on carbachol-induced inositol trisphosphate accumulation and contraction in iris sphincter smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbachol; Cattle; Hydrolysis; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Purinones | 1991 |
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Topics: Adenylyl Cyclases; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Carbachol; Cat Diseases; Cats; Cell Membrane; Cerebral Cortex; Chlorides; Colforsin; G(M1) Ganglioside; Gangliosidoses; Gangliosidosis, GM1; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Reference Values; Sodium Fluoride | 1991 |
Metalloendopeptidase inhibitors and stimulus-secretion coupling in the mouse exocrine pancreas.
Topics: Amylases; Animals; Bombesin; Bucladesine; Calcimycin; Carbachol; Dipeptides; Metalloendopeptidases; Mice; N-Methylscopolamine; Pancreas; Phenanthrolines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Scopolamine Derivatives; Sincalide | 1990 |
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle.
Topics: Animals; Carbachol; Cattle; Chromatography, High Pressure Liquid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Radioisotope Dilution Technique; Trachea; Tritium | 1991 |
Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata.
Topics: Aging; Animals; Arachidonic Acid; Arachidonic Acids; Biotransformation; Carbachol; Corpus Striatum; Dopamine; In Vitro Techniques; Inosine Triphosphate; Male; Neomycin; Oxotremorine; Perfusion; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Second Messenger Systems; Type C Phospholipases | 1990 |
Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cerebral Cortex; GTP-Binding Proteins; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Ions; Lithium; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Potassium; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sodium Fluoride; Type C Phospholipases | 1990 |
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Topics: Animals; Atropine; Carbachol; Cyclic AMP; Parasympatholytics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland | 1990 |
Guanine nucleotides have a direct inhibitory effect on polyphosphoinositide turnover in rat cortical synaptosomes.
Topics: Animals; Carbachol; Cerebral Cortex; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Phosphates; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
Activation of phospholipase C in rabbit brain membranes by carbachol in the presence of GTP gamma S; effects of biological detergents.
Topics: Animals; Brain; Carbachol; Cell Membrane; Detergents; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rabbits; Thionucleotides; Type C Phospholipases; Uncoupling Agents | 1990 |
Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan.
Topics: Bee Venoms; Calcium; Carbachol; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Neuroblastoma; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Thionucleotides; Tumor Cells, Cultured; Type C Phospholipases; Wasp Venoms | 1989 |
Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbachol; Cell Membrane; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Inbred Strains; Substrate Specificity; Thionucleotides; Type C Phospholipases | 1989 |
Calcium-dependent pirenzepine-sensitive muscarinic response in the rat hippocampal slice.
Topics: Animals; Calcium; Carbachol; Hippocampus; In Vitro Techniques; Membrane Potentials; Oxotremorine; Parasympathomimetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic | 1988 |
Beta-adrenergic receptor stimulation induces inositol trisphosphate production and Ca2+ mobilization in rat parotid acinar cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Atenolol; Calcium; Carbachol; Cyclic AMP; Cytosol; Egtazic Acid; Enkephalins; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoproterenol; Male; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Propanolamines; Propranolol; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Sugar Phosphates | 1988 |
Tetraenoic species are conserved in muscarinically enhanced inositide turnover.
Topics: Animals; Carbachol; Cerebral Cortex; Diglycerides; Guinea Pigs; Inositol Phosphates; Nerve Endings; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Receptors, Muscarinic | 1985 |
Receptor interactions in stimulation of hydrolysis of inositol phospholipids.
Topics: Animals; Carbachol; Hydrolysis; In Vitro Techniques; Mice; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Cell Surface; Sincalide | 1985 |
Phosphatidylinositol hydrolysis and phosphatidylinositol 4',5-diphosphate hydrolysis are separable responses during secretagogue action in the rat pancreas.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Carbachol; Cholecystokinin; Cyclic AMP; Egtazic Acid; Hydrolysis; Insulin; Pancreas; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipases A; Rats; Secretin; Type C Phospholipases | 1985 |
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.
Topics: Animals; Carbachol; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Sugar Phosphates | 1985 |
Acute and chronic effects of ethanol on receptor-mediated phosphatidylinositol 4,5-bisphosphate breakdown in mouse brain.
Topics: Animals; Benzodiazepinones; Brain; Carbachol; Cerebral Cortex; Corpus Striatum; Ethanol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pirenzepine; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1986 |
Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate.
Topics: Animals; Calcium Channels; Carbachol; Chromatography, High Pressure Liquid; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipids; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Sugar Phosphates | 1986 |
Muscarinic receptor stimulated phosphoinositide turnover in cardiac atrial tissue.
Topics: Animals; Calcium; Carbachol; Dogs; Female; Heart Atria; Male; Myocardium; Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Receptors, Muscarinic; Time Factors; Verapamil | 1987 |
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands.
Topics: Animals; Carbachol; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; In Vitro Techniques; Inositol Phosphates; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Receptors, Muscarinic; Sugar Phosphates | 1987 |
Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol pho
Topics: Animals; Calcimycin; Carbachol; Cations; Female; In Vitro Techniques; Inositol Phosphates; Iris; Male; Muscle, Smooth; Norepinephrine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Prazosin; Quinazolines; Rabbits; Sugar Phosphates; Time Factors | 1984 |
Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands.
Topics: Animals; Carbachol; Diglycerides; In Vitro Techniques; Inositol; Male; Parotid Gland; Phenylephrine; Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Stimulation, Chemical; Substance P; Sympathectomy | 1983 |
Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle.
Topics: Acetylcholine; Animals; Calcimycin; Calcium; Carbachol; Female; Hydrolysis; In Vitro Techniques; Inositol; Iris; Male; Microsomes; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rabbits | 1980 |
Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas.
Topics: Animals; Atropine; Calcium; Carbachol; Ceruletide; Ethers; In Vitro Techniques; Ionomycin; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats | 1983 |
Decreased m3-muscarinic and alpha 1-adrenergic receptor stimulation of PIP2 hydrolysis in parotid gland membranes from aged rats: defect in activation of G alpha q/11.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Aging; Aluminum Compounds; Animals; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Isoenzymes; Membranes; Muscarinic Agonists; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phospholipase C beta; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Receptors, Neurotransmitter; Signal Transduction; Type C Phospholipases | 1995 |
Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells.
Topics: Adrenergic beta-Agonists; Animals; Atropine; Carbachol; Cell Transformation, Viral; Cells, Cultured; Cornea; Cyclic AMP; Dose-Response Relationship, Drug; Epithelium; Hydrolysis; Inositol Phosphates; Isoproterenol; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phospholipids; Rabbits; Receptors, Muscarinic; Time Factors; Type C Phospholipases | 1995 |
Lysophosphatidic acid induces inositol phosphate and calcium signals in exocrine cells from the avian nasal salt gland.
Topics: Acetylcholine; Animals; Atropine; Calcium; Carbachol; Chromatography, High Pressure Liquid; Ducks; GTP-Binding Proteins; Inositol Phosphates; Lysophospholipids; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Receptors, Muscarinic; Salt Gland; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Phosphoinositide synthesis in desensitized rat pancreatic acinar cells.
Topics: Animals; Carbachol; Ceruletide; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol; Kinetics; Male; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tritium | 1995 |
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; Female; Frontal Lobe; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Male; Middle Aged; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Pirenzepine; Receptors, Muscarinic; Reference Values; Regression Analysis; Synaptic Membranes; Synaptosomes | 1995 |
Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Female; Inositol 1,4,5-Trisphosphate; Male; Memantine; N-Methylaspartate; Neurotoxins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Polyphosphates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Disruption by lithium of phosphatidylinositol-4,5-bisphosphate supply and inositol-1,4,5-trisphosphate generation in Chinese hamster ovary cells expressing human recombinant m1 muscarinic receptors.
Topics: Animals; Carbachol; CHO Cells; Cricetinae; Cricetulus; Cytidine Monophosphate; Glycerophospholipids; Humans; Inositol 1,4,5-Trisphosphate; Lithium; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Receptors, Muscarinic; Recombinant Proteins | 1994 |
Alpha 1-adrenergic and m3-muscarinic receptor stimulation of phosphatidylinositol 4,5-bisphosphate-specific phospholipase C are independently mediated by G alpha q/11 in rat parotid gland membranes.
Topics: Animals; Carbachol; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Isoenzymes; Male; Membranes; Parotid Gland; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1995 |
Identification of phosphoinositide-specific phospholipase C-beta 1 and GTP-binding protein, Gq alpha, in bovine iris sphincter membranes: characteristics of the phospholipase and its coupling to cholinergic muscarinic receptors.
Topics: Animals; Calcium; Carbachol; Cattle; Cell Membrane; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Iris; Magnesium; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphorylation; Type C Phospholipases | 1994 |
Guanosine-5'-(3-O-thio)triphosphate-mediated stimulation of phosphoinositidase C in solubilized rat peripheral nerve myelin and its alteration in streptozotocin-induced diabetes.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Atropine; Carbachol; Cholic Acid; Cholic Acids; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Myelin Sheath; Peripheral Nerves; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sciatic Nerve; Streptozocin; Thionucleotides | 1994 |
Studies on the properties of myo-inositol-1,4,5-trisphosphate 5-phosphatase and myo-inositol monophosphatase in bovine iris sphincter smooth muscle: effects of okadaic acid and protein phosphorylation.
Topics: Animals; Carbachol; Cattle; Disulfiram; Enzyme Activation; Ethers, Cyclic; Hydrogen-Ion Concentration; Inositol Polyphosphate 5-Phosphatases; Iris; Kinetics; Magnesium; Muscle Contraction; Muscle, Smooth; Okadaic Acid; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoric Monoester Hydrolases; Phosphorylation; Sulfhydryl Reagents | 1994 |
Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Binding, Competitive; Carbachol; Cell Membrane; Choline O-Acetyltransferase; Frontal Lobe; Humans; Hydrolysis; Inositol Phosphates; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositol Phosphates; Phosphoric Diester Hydrolases; Pirenzepine; Receptors, Muscarinic; Reference Values; Synaptic Membranes; Type C Phospholipases | 1993 |
Phospholipid metabolism under muscarinic cholinergic stimulation exhibits brain asymmetry.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Functional Laterality; Male; Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Rats; Rats, Wistar; Receptors, Muscarinic; Synaptosomes | 1993 |
Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
Topics: Calcium; Carbachol; Chlorides; Chromatography, Thin Layer; Colonic Neoplasms; Cyclic AMP; Cytosol; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Inositol Phosphates; Kinetics; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipids; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1993 |
Common phosphatidylinositol 4,5-bisphosphate pools are involved in carbachol and serotonin activation of tracheal smooth muscle.
Topics: Animals; Carbachol; Dogs; Drug Interactions; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Serotonin; Trachea | 1993 |
m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis.
Topics: Carbachol; Cells, Cultured; Embryo, Mammalian; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Humans; Kidney; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Receptors, Muscarinic; Receptors, Purinergic; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Thrombin; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Muscarinic regulation of phospholipase D and its role in arachidonic acid release in rat submandibular acinar cells.
Topics: Animals; Arachidonic Acid; Calcium; Carbachol; Chelating Agents; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Male; Muscarinic Agonists; Phosphatidylcholines; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Submandibular Gland; Type C Phospholipases | 1995 |
Muscarinic acetylcholine receptor-mediated induction of zif268 mRNA in PC12D cells requires protein kinase C and the influx of extracellular calcium.
Topics: Animals; Calcium; Carbachol; DNA-Binding Proteins; Early Growth Response Protein 1; Extracellular Space; Immediate-Early Proteins; Muscarinic Agonists; Oxotremorine; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Rats; Receptors, Muscarinic; RNA, Messenger; Transcription Factors | 1997 |
Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Carbachol; Cats; Cell Fractionation; Cell Membrane; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Inositol 1,4,5-Trisphosphate; Iris; Isoproterenol; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Ryanodine; Thapsigargin; Type C Phospholipases | 1997 |
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
Topics: Androstadienes; Atropine; Carbachol; Cations, Monovalent; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Sympathetic; Hydrolysis; Inositol 1,4,5-Trisphosphate; Lithium; Morpholines; Muscarinic Agonists; Muscarinic Antagonists; Neuroblastoma; Neurons; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin | 1998 |
Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.
Topics: Adenosine Triphosphate; Carbachol; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Humans; Inositol Phosphates; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Receptors, Muscarinic; Type C Phospholipases | 1998 |
Stimulation by iodide of H(2)O(2) generation in thyroid slices from several species.
Topics: Animals; Carbachol; Cattle; Cyclic AMP; Dogs; Horses; Humans; Hydrogen Peroxide; In Vitro Techniques; Inositol Phosphates; Iodides; Muscarinic Agonists; Oxidation-Reduction; Phosphatidylinositol 4,5-Diphosphate; Sheep; Species Specificity; Thyroid Gland; Thyrotropin | 2000 |
Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.
Topics: Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Hydrolysis; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscarinic Antagonists; Phosphatidylinositol 4,5-Diphosphate; Protein Isoforms; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Transfection | 2000 |
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
Topics: Affinity Labels; Animals; Azides; Carbachol; Cholera Toxin; Cholinergic Agonists; Elapid Venoms; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Hydrolysis; In Vitro Techniques; Male; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphorus Radioisotopes; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Specific Pathogen-Free Organisms; Sublingual Gland; Virulence Factors, Bordetella | 2001 |
Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans.
Topics: Adenoviridae; Androstadienes; Animals; Carbachol; Cholinergic Agonists; Chromatography, High Pressure Liquid; Chromones; Enzyme Inhibitors; Genistein; Hydrolysis; Inositol Phosphates; Islets of Langerhans; Isoenzymes; Membrane Potentials; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine; Vanadates; Wortmannin | 2001 |
Regulation of phospholipase Cbeta activity by muscarinic acetylcholine and 5-HT(2) receptors in crude and synaptosomal membranes from human cerebral cortex.
Topics: Adult; Carbachol; Cerebral Cortex; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; In Vitro Techniques; Isoenzymes; Male; Middle Aged; Muscarinic Agonists; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Receptors, Muscarinic; Receptors, Serotonin; Subcellular Fractions; Synaptic Membranes; Synaptosomes; Type C Phospholipases | 2001 |
Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines.
Topics: Animals; Carbachol; Cerebral Cortex; Cholinergic Agonists; Genetics, Behavioral; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Isoenzymes; Male; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Rats; Signal Transduction; Species Specificity; Tryptamines; Type C Phospholipases | 2001 |
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.
Topics: Animals; Blood Proteins; Calcium Signaling; Carbachol; CHO Cells; Cricetinae; Green Fluorescent Proteins; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Luminescent Proteins; Microscopy, Confocal; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phosphoproteins; Receptor, Muscarinic M3; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Neurotransmitter; Sequence Homology, Amino Acid | 2001 |
Smooth muscle length-dependent PI(4,5)P2 synthesis and paxillin tyrosine phosphorylation.
Topics: Animals; Carbachol; Cholinergic Agonists; Cytoskeletal Proteins; Immunoblotting; In Vitro Techniques; Inositol; Integrin beta1; Muscle, Smooth; Paxillin; Phosphatidylinositol 4,5-Diphosphate; Phosphoproteins; Phosphorylation; Signal Transduction; Swine; Trachea | 2001 |
Phosphatidylinositol 4,5-bisphosphate modifies tubulin participation in phospholipase Cbeta1 signaling.
Topics: Animals; Azides; Carbachol; Cell Line; Cell Membrane; Cholinergic Agonists; Dose-Response Relationship, Drug; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Hydrolysis; Isoenzymes; Luminescent Proteins; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Signal Transduction; Spodoptera; Transfection; Tubulin; Type C Phospholipases | 2002 |
The TRPM7 channel is inactivated by PIP(2) hydrolysis.
Topics: Animals; Carbachol; Cell Line; Cholinergic Agonists; Diglycerides; Heart; Humans; Hydrolysis; Ion Channels; Membrane Proteins; Models, Biological; Myocardium; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Fusion Proteins; TRPM Cation Channels; Two-Hybrid System Techniques; Type C Phospholipases; Yeasts | 2002 |
A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma.
Topics: Animals; Bombesin; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Enzyme Inhibitors; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Ionomycin; Mice; Oocytes; Pancreas; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Type C Phospholipases; Xenopus | 2003 |
G beta gamma mediates the interplay between tubulin dimers and microtubules in the modulation of Gq signaling.
Topics: Animals; Baculoviridae; Blotting, Western; Carbachol; Cell Line; Cell Membrane; Colchicine; Cross-Linking Reagents; Cytoskeleton; Cytosol; Dimerization; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Heterotrimeric GTP-Binding Proteins; Humans; Hydrolysis; Insecta; Isoenzymes; Microscopy, Confocal; Microtubules; Paclitaxel; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Precipitin Tests; Protein Structure, Tertiary; Protein Transport; Radiation-Sensitizing Agents; Signal Transduction; Time Factors; Transcriptional Activation; Tubulin; Tumor Cells, Cultured; Type C Phospholipases | 2003 |
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities.
Topics: Animals; Bombesin; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Carbachol; Carrier Proteins; Cholecystokinin; Cholinergic Agonists; Enzyme Inhibitors; Gene Deletion; GTP-Binding Proteins; GTPase-Activating Proteins; Homer Scaffolding Proteins; Indoles; Isoenzymes; Mice; Mice, Knockout; Neuropeptides; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Protein Isoforms; RGS Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Type C Phospholipases | 2003 |
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Carbachol; Cations; Cell Line; Cold Temperature; Diphosphates; Fluorides; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Ion Channel Gating; Ion Channels; Ion Transport; Kidney; Membrane Lipids; Menthol; Muscarinic Agonists; Neoplasm Proteins; Oocytes; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Rats; Receptor, Muscarinic M1; Receptor, trkA; Recombinant Fusion Proteins; TRPM Cation Channels; Vanadates; Wortmannin; Xenopus laevis | 2005 |
Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.
Topics: Animals; Carbachol; CHO Cells; Cholinergic Agonists; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electric Stimulation; Extracellular Space; Green Fluorescent Proteins; Humans; Ion Channel Gating; KCNQ Potassium Channels; Membrane Potentials; Muscarinic Agonists; Oncogene Protein v-akt; Oxotremorine; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphotransferases (Alcohol Group Acceptor); Probability; src-Family Kinases; Structure-Activity Relationship; Transfection | 2005 |
Dual control of cardiac Na+ Ca2+ exchange by PIP(2): electrophysiological analysis of direct and indirect mechanisms.
Topics: Animals; Carbachol; Cell Line; Electrophysiology; Heart; Membrane Potentials; Mice; Microscopy, Confocal; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Sodium-Calcium Exchanger; Type C Phospholipases | 2007 |
Decrease in PIP(2) channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA(B)-activated K+ current.
Topics: Animals; Arachidonic Acid; Baclofen; Carbachol; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hippocampus; Ion Channels; Kinetics; Methoxyhydroxyphenylglycol; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Pyramidal Cells; Rats | 2007 |
Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Calcium; Calcium Signaling; Carbachol; Cell Line; Cholinergic Agonists; Chromones; Enzyme Inhibitors; Humans; Ion Channel Gating; Methacholine Chloride; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Sirolimus; TRPC Cation Channels; Type C Phospholipases; Wortmannin | 2009 |
Involvement of phosphatidylinositol 4,5-bisphosphate in the desensitization of canonical transient receptor potential 5.
Topics: Actins; Animals; Carbachol; Cell Line, Tumor; Cell Separation; Cytoskeleton; Female; Humans; Ileum; Male; Mice; Mice, Inbred ICR; Muscarinic Agonists; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Transfection; TRPC Cation Channels | 2008 |
Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Cell Line; Cholinergic Agents; Ganglia, Spinal; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Microdomains; Membrane Potentials; Mice; Muscarine; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Potassium Channel Blockers; Potassium Channels; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic | 2009 |
Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons.
Topics: Amyloid beta-Protein Precursor; Androstadienes; Animals; Carbachol; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Mice; Mice, Transgenic; Muscarinic Agonists; Neurons; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2009 |
BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation.
Topics: Animals; Biosensing Techniques; Carbachol; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Feedback, Physiological; Fluorescence Resonance Energy Transfer; HEK293 Cells; Humans; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lipolysis; Muscarinic Agonists; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Fusion Proteins; Signal Transduction; Transfection; Type C Phospholipases; Up-Regulation | 2016 |