captopril has been researched along with thiorphan in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (36.14) | 18.7374 |
| 1990's | 35 (42.17) | 18.2507 |
| 2000's | 11 (13.25) | 29.6817 |
| 2010's | 4 (4.82) | 24.3611 |
| 2020's | 3 (3.61) | 2.80 |
| Authors | Studies |
|---|---|
| Berry, CJ; Fink, CA; Ghai, RD; Qiao, Y; Sakane, Y; Trapani, AJ | 1 |
| Crippen, GM | 1 |
| Coric, P; Fournié-Zaluski, MC; Inguimbert, N; Meudal, H; Poras, H; Roques, BP; Teffot, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Fustero, S; Lazzari, P; Olimpieri, F; Pani, L; Sanchez-Roselló, M; Tambaro, S; Volonterio, A; Zanda, M | 1 |
| Devi, LA; Fournié-Zaluski, MC; Gagnidze, K; Orng, SV; Ouimet, T; Poras, H; Roques, BP | 1 |
| Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM | 1 |
| Buee, L; Charton, J; Deprez, B; Deprez-Poulain, R; Dumont, J; Flipo, M; Gauriot, M; Guo, Q; Hamdane, M; Hennuyer, N; Landry, V; Leroux, F; Marechal, X; Pottiez, V; Sperandio, O; Staels, B; Tang, WJ | 1 |
| Bai, W; Cheng, K; Gao, Y; Guo, H; He, W; Li, C; Li, Z; Wu, C | 1 |
| Debuchi, H; Nakagawa, H | 1 |
| Drazen, JM; Martins, MA; Shore, SA | 2 |
| Conlon, JM; Gao, XP; Koizumi, S; Mayhan, WG; Rennard, SI; Rubinstein, I; Yong, T | 1 |
| Gintzler, AR; Sublette, E | 1 |
| Kisara, K; Sakurada, S; Sakurada, T; Sasaki, Y; Suzuki, K; Watanabe, H | 1 |
| Håkanson, R; Wang, ZY | 1 |
| Barnes, NM; Costall, B; Egli, P; Horovitz, ZP; Ironside, JW; Naylor, RJ; Williams, TJ | 1 |
| Bachoo, M; Polosa, C; Zhang, C | 1 |
| Drazen, JM; Gerard, C; Gerard, NP; Martins, MA; Shore, SA | 1 |
| Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Krell, RD; McCarthy, M | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 1 |
| Horii, S; Kanemura, T; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Fischer, A; Kummer, W | 1 |
| McGraw, DE; Smits, GJ; Trapani, AJ | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P | 1 |
| Farmer, SG; Togo, J | 1 |
| Drummer, OH; Johnson, H; Kourtis, S | 1 |
| Stimler-Gerard, NP | 1 |
| Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A | 1 |
| Coats, SR; Drazen, JM; Shore, SA; Stimler-Gerard, NP | 1 |
| Drazen, JM; Gerard, NP; Shore, SA | 1 |
| Drapeau, G; Maggi, CA; Meli, A; Patacchini, R; Regoli, D; Renzi, D; Rovero, P; Santicioli, P; Surrenti, C | 1 |
| Blaine, EH; Koepke, JP; McGraw, DE; Olins, GM; Smits, GJ; Spear, KL; Trapani, AJ | 1 |
| Geppetti, P; Maggi, CA; Rubini, I; Santicioli, P; Sicuteri, F; Spillantini, MG | 1 |
| Drazen, JM; Shore, SA | 1 |
| Griesbacher, T; Hill, RG; Hughes, J; Leighton, GE | 1 |
| Autry, WL; Barbaz, BS; Norman, JA | 1 |
| Aoki, K; Kajiwara, M; Oka, T | 2 |
| Federigo, S; Grazia, SM; Marcello, F; Sergio, M | 1 |
| Basilico, L; Giagnoni, G; Gori, E; Mennuni, L; Parolaro, D; Pecora, N | 1 |
| Borson, DB; Jacoby, DB; Nadel, JA; Tamaoki, J | 1 |
| Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE | 1 |
| Borson, DB; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K | 1 |
| Hill, RG; Hughes, J; Pittaway, KM | 1 |
| Hiranuma, T; Oka, T | 1 |
| Coquerel, A; Costentin, J; Dubuc, I; Kitabgi, P; Menard, JF | 1 |
| Anadón, A; Martinez-Larrañaga, MR | 1 |
| Besselievre, R; Bouboutou, R; Devin, J; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Gros, C; Llorens-Cortes, C; Schwartz, JC | 1 |
| Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY | 1 |
| Checler, F; Kitabgi, P; Vincent, JP | 1 |
| Brandt, U; Lentzen, H; Palenker, J | 1 |
| Checler, F; Emson, PC; Kitabgi, P; Vincent, JP | 1 |
| Barnett, A; Berger, J; Billard, W; Chipkin, RE; Iorio, LC | 1 |
| Costa, E; Harsing, LG; Majane, EM; Yang, HY | 1 |
| Harty, GJ; Yaksh, TL | 1 |
| Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Brouard, R; Brunner, HR; Burnier, M; Favrat, B; Lecomte, JM; Nussberger, J; Waeber, B | 1 |
| Hosoki, R; Otsuka, M; Saito, K; Seno, N; Suzuki, H; Yanagisawa, M | 1 |
| Botyánszki, J; Fehér, E; Hepp, J; Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Battistini, B; Brown, M; Vane, JR | 1 |
| Broom, T; DeSiato, MA; Farmer, SG | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Joos, GF; Pauwels, RA | 1 |
| Belowski, D; Gabryel, B; Herman, ZS; Klin, M; Kowalski, J; Wielgus, J | 1 |
| Gao, XP; Olopade, CO; Rubinstein, I; Suzuki, H | 1 |
| D'Orléans-Juste, P; Fournier, A; Lebel, N; Sirois, P | 1 |
| Chakir, M; D'Orléans-Juste, P; Plante, GE | 1 |
| Gao, XP; Olopade, CO; Pakhlevaniants, S; Rubinstein, I; Suzuki, H | 1 |
| Arbin, V; Claperon, N; Fournié-Zaluski, MC; Peyroux, J; Roques, BP | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Miyamoto, A; Murata, S; Nishio, A | 1 |
| Brooks, DP; Edwards, RM; Pullen, MA; Sulpizio, AC | 1 |
| Burssens, P; De Paepe, Y; Depaepe, Y; Forsyth, R; Steyaert, A; van Ovost, EJ; Verdonk, R | 1 |
| Burssens, PJ; Steyaert, AE; Vanderstraeten, GG; Verbeeck, RM; Vercruysse, CW | 1 |
| Guo, H; Pan, Y; Qi, F; Sheng, L; Yin, H; Zhang, T | 1 |
| Berry, C; Biggerstaff, F; Clarke, A; Dalzell, JR; Hillier, C; McMurray, JJ; Padmanabhan, N; Petrie, MC; Seed, A; Whelan, CJ | 1 |
| Bagley, EE; Gregoriou, GC; Patel, SD; Winters, BL | 1 |
| Do, TG; Huynh, PNH; Nguyen, DN; Nguyen, TT; Thai, KM; Tran, VH; Tran, VT; Vo, TP | 1 |
| Abbenante, G; Fairlie, DP; Leung, D | 1 |
1 review(s) available for captopril and thiorphan
| Article | Year |
|---|---|
Protease inhibitors: current status and future prospects.
Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Metalloendopeptidases; Models, Molecular; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors | 2000 |
1 trial(s) available for captopril and thiorphan
| Article | Year |
|---|---|
Neutral endopeptidase versus angiotensin converting enzyme inhibition in essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan | 1995 |
81 other study(ies) available for captopril and thiorphan
| Article | Year |
|---|---|
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Dipeptides; Magnetic Resonance Spectroscopy; Male; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Thiorphan; Tryptophan | 1995 |
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin | 1997 |
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Topics: Amino Acids; Aspartic Acid Endopeptidases; Blood Pressure; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Endothelin-Converting Enzymes; Humans; Kinetics; Magnetic Resonance Spectroscopy; Metalloendopeptidases; Models, Chemical; Models, Molecular; Neprilysin; Peptides; Peptidyl-Dipeptidase A; Protein Binding; Protein Conformation; Stereoisomerism | 2002 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Fluorine; Humans; Neprilysin; Peptides; Peptidyl-Dipeptidase A; Protease Inhibitors; Sulfhydryl Compounds | 2009 |
Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-Converting Enzymes; Endothelins; Enzyme Assays; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Humans; Metalloendopeptidases; Mice; Organ Specificity; Peptide Library; Peptides; Substrate Specificity | 2010 |
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin | 2011 |
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.
Topics: Acetates; Amyloid beta-Peptides; Dose-Response Relationship, Drug; Humans; Hydrolysis; Imidazoles; Insulysin; Molecular Structure; Small Molecule Libraries; Structure-Activity Relationship; Tumor Cells, Cultured | 2014 |
A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening.
Topics: Anti-Bacterial Agents; beta-Lactamases; Coordination Complexes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Klebsiella pneumoniae; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Surface Plasmon Resonance; Zinc | 2020 |
Inactivation of substance P by granulation tissue-derived gelatinase.
Topics: Animals; Captopril; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Gelatin; Granulation Tissue; Hydrolysis; Kinetics; Male; Peptide Fragments; Protease Inhibitors; Rats; Rats, Wistar; Substance P; Thiorphan | 1992 |
Effect of the NEP inhibitor SCH32615 on airway responses to intravenous substance P in guinea pigs.
Topics: Airway Resistance; Animals; Blood Pressure; Captopril; Dipeptides; Guinea Pigs; Injections, Intravenous; Male; Neprilysin; Neurokinin A; Substance P; Thiorphan | 1992 |
Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.
Topics: Animals; Bradykinin; Capillary Permeability; Captopril; Cheek; Cricetinae; Glycopeptides; Inflammation; Microcirculation; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan | 1992 |
Stimulus frequency and intensity: critical determinants of opioid enhancement or inhibition of evoked methionine-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Captopril; Cyclic AMP; Dipeptides; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Leucine; Muscle, Smooth; Myenteric Plexus; Protease Inhibitors; Pyrrolidines; Thiorphan | 1992 |
Different effects of peptidase inhibitors on dermorphin- and on [D-Arg2]dermorphin-induced antinociceptive activity.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Captopril; Male; Mice; Mice, Inbred Strains; Oligopeptides; Opioid Peptides; Pain Measurement; Peptides; Thiorphan | 1992 |
Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Captopril; Diterpenes; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Rabbits; Substance P; Tachykinins; Tachyphylaxis; Thiorphan | 1992 |
Characterisation of [3H]ceranapril recognition sites in rat and human brain tissue.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Brain; Captopril; Enalapril; Female; Fosinopril; Humans; Kinetics; Lisinopril; Male; Middle Aged; Organophosphorus Compounds; Proline; Rats; Thiorphan | 1991 |
Naloxone-sensitive inhibition of nicotinic transmission in the superior cervical ganglion of the cat.
Topics: Action Potentials; Animals; Axons; Captopril; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; Hexamethonium; Hexamethonium Compounds; Leucine; Male; Naloxone; Protease Inhibitors; Receptors, Nicotinic; Synapses; Synaptic Transmission; Thiorphan | 1991 |
Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs.
Topics: Animals; Captopril; Dipeptides; Guinea Pigs; Kinetics; Lung; Male; Neurokinin A; Peptide Hydrolases; Perfusion; Substance P; Thiorphan; Trachea | 1990 |
Peptidase modulation of the pulmonary effects of tachykinins.
Topics: Animals; Captopril; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Neprilysin; Neurokinin A; Perfusion; Substance P; Thiorphan | 1991 |
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea | 1991 |
Pharmacologic analysis of platelet activating factor16- and 18-induced bronchoconstriction in the guinea pig.
Topics: Animals; Atropine; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Leukocyte Count; Lung; Male; Methysergide; Platelet Activating Factor; Platelet Count; Propranolol; Pyrilamine; Respiratory Function Tests; Thiorphan | 1991 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Effects of beta-endorphin and dynorphin A on cholinergic neurotransmission in canine airway smooth muscle.
Topics: Animals; beta-Endorphin; Bronchi; Captopril; Dogs; Dynorphins; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Protease Inhibitors; Synaptic Transmission; Thiorphan | 1990 |
Tissue distribution of neutral endopeptidase 24.11 ('enkephalinase') activity in guinea pig trachea.
Topics: Animals; Bacitracin; Captopril; Enalapril; Epithelium; Female; Glycopeptides; Guinea Pigs; Immunohistochemistry; Neprilysin; Thiorphan; Trachea | 1991 |
Interaction of ANP and bradykinin during endopeptidase 24.11 inhibition: renal effects.
Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Captopril; Diuretics; Drug Synergism; Kidney; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Inbred Strains; Thiorphan | 1990 |
Further studies on the response of the guinea-pig isolated bronchus to endothelins and sarafotoxin S6b.
Topics: Animals; Aorta, Thoracic; Bronchi; Captopril; Endothelins; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Leucine; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Viper Venoms | 1990 |
Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation.
Topics: Animals; Atropine; Captopril; Electric Stimulation; Endopeptidases; Epithelium; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Propranolol; Protease Inhibitors; Thiorphan; Trachea; Vasoactive Intestinal Peptide | 1990 |
Effect of chronic enalapril treatment on enzymes responsible for the catabolism of angiotensin I and formation of angiotensin II.
Topics: Aminopeptidases; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Bacterial Agents; Captopril; Carboxypeptidases; Chromatography, High Pressure Liquid; Enalapril; Kidney; Neprilysin; Oligopeptides; Peptide Fragments; Peptides; Rats; Rats, Inbred WKY; Thiorphan | 1990 |
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complement C5; Complement C5a; Drug Interactions; Endopeptidases; Glycopeptides; Guinea Pigs; Lung; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Peptidyl-Dipeptidase A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Thiorphan; Tiopronin; Trachea | 1987 |
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin | 1987 |
Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme.
Topics: Amino Acids, Sulfur; Angiotensin-Converting Enzyme Inhibitors; Animals; Bronchi; Captopril; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Methacholine Chloride; Methacholine Compounds; Plethysmography, Whole Body; Protease Inhibitors; Respiration, Artificial; Substance P; Thiorphan; Time Factors; Tiopronin | 1988 |
Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril.
Topics: Animals; Blood Pressure; Captopril; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Lung; Male; Perfusion; Pulmonary Artery; Substance P; Thiorphan | 1989 |
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Substance P; Tachykinins; Thiorphan | 1989 |
Thiorphan, an inhibitor of endopeptidase 24.11, potentiates the natriuretic activity of atrial natriuretic peptide.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Drug Synergism; Hemodynamics; Iodine Radioisotopes; Kidney; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Inbred Strains; Sodium; Thiorphan | 1989 |
Thiorphan increases capsaicin-evoked release of substance P from slices of dorsal spinal cord of guinea pig.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Captopril; Female; Guinea Pigs; Kinetics; Male; Neprilysin; Neuropeptides; Spinal Cord; Substance P; Thiorphan | 1989 |
Degradative enzymes modulate airway responses to intravenous neurokinins A and B.
Topics: Animals; Bronchi; Captopril; Guinea Pigs; Infusions, Intravenous; Male; Neprilysin; Neurokinin A; Neurokinin B; Thiorphan; Trachea | 1989 |
Reduction of food intake by central administration of cholecystokinin octapeptide in the rat is dependent upon inhibition of brain peptidases.
Topics: Animals; Brain; Captopril; Ceruletide; Eating; Injections, Intraventricular; Leucine; Male; Protease Inhibitors; Rats; Rats, Inbred Strains; Sincalide; Thiorphan | 1989 |
Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Captopril; Enalapril; Enalaprilat; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Peptidyl-Dipeptidase A; Synaptic Membranes; Thiorphan; Tiopronin | 1985 |
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens | 1986 |
Pharmacological "enkephalinase" inhibition in man.
Topics: Amino Acids, Sulfur; Captopril; Endopeptidases; Headache; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Protease Inhibitors; Stereoisomerism; Thiorphan; Tiopronin | 1986 |
Binding studies of dermorphin and its L-form on rat brain opioid receptors.
Topics: Alanine; Animals; Binding, Competitive; Biological Assay; Brain; Captopril; Ileum; Leucine; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; Thiorphan; Tiopronin | 1987 |
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine; Leupeptins; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Thiorphan; Tiopronin; Trachea | 1988 |
Characterization of enkephalin degradation in rat plasma.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Ferrets; Glycopeptides; Kinins; Male; Metalloendopeptidases; Muscle Contraction; Neprilysin; Thiorphan; Tiopronin; Trachea | 1988 |
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin | 1987 |
Effects of peptidase inhibitors on the [Met5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan.
Topics: Animals; Anti-Bacterial Agents; Captopril; Corpus Striatum; Enkephalin, Methionine; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Male; Membranes; Oligopeptides; Peptides; Protease Inhibitors; Thiorphan; Tiopronin | 1986 |
Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan.
Topics: Amino Acids, Sulfur; Animals; Body Temperature; Captopril; Drug Synergism; Endopeptidases; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Neurotensin; Thiorphan; Tiopronin | 1986 |
An inhibitory action of tetracyclines on guinea-pig myenteric plexus.
Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leucine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Protease Inhibitors; Tetracyclines; Thiorphan; Tiopronin | 1987 |
Binding of the bidentate inhibitor [3H]HACBO-Gly to the rat brain neutral endopeptidase "enkephalinase".
Topics: Animals; Brain; Captopril; Cell Membrane; Corpus Striatum; Glycine; Hydroxylamines; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin; Tissue Distribution | 1985 |
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin | 1985 |
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception.
Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1984 |
Degradation of neurotensin by rat brain synaptic membranes: involvement of a thermolysin-like metalloendopeptidase (enkephalinase), angiotensin-converting enzyme, and other unidentified peptidases.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Endopeptidases; Kinetics; Male; Neprilysin; Neurotensin; Peptide Hydrolases; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Inbred Strains; Synaptic Membranes; Thiorphan; Tiopronin | 1983 |
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase.
Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine | 1984 |
In vitro and in vivo effects of thiorphan: an inhibitor of enkephalinase A.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesics; Animals; Captopril; Drug Synergism; Enkephalins; In Vitro Techniques; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
Possible role of dipeptidyl carboxypeptidase n the metabolism of Met5-enkephalin and Met5-enkephalin-Arg6-Phe7.
Topics: Animals; Captopril; Cattle; Chlorides; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1982 |
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Captopril; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Injections, Spinal; Macaca; Morphine; Neprilysin; Protease Inhibitors; Rats; Species Specificity; Thiorphan; Tiopronin | 1982 |
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains.
Topics: Airway Resistance; Animals; Atropine; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Methysergide; Neurokinin A; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Tachykinin; Serotonin; Substance P; Thiorphan | 1994 |
A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Captopril; Electric Stimulation; Endothelins; Guinea Pigs; Humans; Leucine; Male; Muscle Contraction; Muscle, Smooth; Thiorphan; Ureter | 1994 |
Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal rat.
Topics: Animals; Animals, Newborn; Captopril; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guanidines; Hydroxamic Acids; In Vitro Techniques; Kinetics; Leucine; Nerve Fibers; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Tetrodotoxin; Thiorphan | 1993 |
Substrate- and inhibitor-specificity of a non-endothelial enzyme which forms [Met5]-enkephalin from [Met5]-enkephalin-Arg6,Phe7 in isolated rabbit ear artery: pharmacological characterization.
Topics: Amino Acid Sequence; Angiotensin I; Animals; Arteries; Bradykinin; Captopril; Disease Models, Animal; Ear, External; Enalapril; Endopeptidases; Endothelium, Vascular; Enkephalin, Methionine; Male; Migraine Disorders; Molecular Sequence Data; Rabbits; Substrate Specificity; Thiorphan | 1995 |
Selective proteolitic activation and degradation of ETs and big ETs in parenchymal strips of the guinea-pig lung.
Topics: Animals; Captopril; Endopeptidases; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Humans; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Protein Precursors; Structure-Activity Relationship; Swine; Thiorphan | 1995 |
Effects of bradykinin receptor agonists, and captopril and thiorphan in ferret isolated trachea: evidence for bradykinin generation in vitro.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Ferrets; In Vitro Techniques; Male; Muscle Contraction; Receptors, Bradykinin; Thiorphan; Trachea | 1994 |
Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum.
Topics: Aminopeptidases; Animals; Bacitracin; Captopril; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; Leucine; Male; Morphine; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Thiorphan | 1994 |
The in vivo effect of tachykinins on airway mast cells of the rat.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Carbachol; Dose-Response Relationship, Drug; Histamine; Male; Mast Cells; Neprilysin; p-Methoxy-N-methylphenethylamine; Peptidyl-Dipeptidase A; Rats; Rats, Inbred F344; Serotonin; Specific Pathogen-Free Organisms; Tachykinins; Thiorphan | 1993 |
Effect of captopril and thiorphan on the proliferation of human neoplastic cell lines and their influence on cytostatic activity of interferon alpha or cytotoxic activity of doxorubicin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Captopril; Cell Division; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; HL-60 Cells; Humans; Interferon alpha-2; Interferon-alpha; Kinetics; Recombinant Proteins; Thiorphan; Tumor Cells, Cultured | 1995 |
Neutral endopeptidase modulates VIP-induced vasodilation in hamster cheek pouch vessels in situ.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Captopril; Cheek; Cricetinae; Drug Combinations; Glycopeptides; Male; Mesocricetus; Neprilysin; Protease Inhibitors; Thiorphan; Vasoactive Intestinal Peptide; Vasodilation | 1996 |
Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.
Topics: Alanine; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Neprilysin; Protease Inhibitors; Protein Precursors; Thiorphan | 1996 |
Neutral endopeptidase inhibition, a new approach in the exploration of diabetic vasculopathy in rats.
Topics: Alanine; Animals; Blood Pressure; Capillary Permeability; Captopril; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Female; Glycopeptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Streptozocin; Thiorphan | 1995 |
Angiotensin-converting enzyme and neutral endopeptidase modulate smokeless tobacco-induced increase in macromolecular efflux from the oral mucosa in vivo.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillary Permeability; Captopril; Cricetinae; Dextrans; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Glycopeptides; Lisinopril; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neprilysin; Peptidyl-Dipeptidase A; Plants, Toxic; Protease Inhibitors; Thiorphan; Tobacco, Smokeless | 1997 |
Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats.
Topics: 3-Mercaptopropionic Acid; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Flow Velocity; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Femoral Artery; Hemodynamics; Kininogens; Lysine Carboxypeptidase; Male; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Thiorphan; Time Factors | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of ACE and NEP in bradykinin-induced relaxation and contraction response of isolated porcine basilar artery.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Basilar Artery; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Receptor, Bradykinin B2; Swine; Thiorphan; Vasoconstriction; Vasodilation | 2002 |
The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Dose-Response Relationship, Drug; Lung; Male; Neprilysin; Peptidyl-Dipeptidase A; Plasma; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Thiorphan | 2004 |
Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing.
Topics: Achilles Tendon; Animals; Captopril; Cell Proliferation; Collagen; Disease Models, Animal; Drug Combinations; Fibroblasts; Male; Neovascularization, Physiologic; Neprilysin; Protease Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Rupture; Substance P; Tendon Injuries; Thiorphan; Treatment Outcome; Wound Healing | 2005 |
The effects of substance P on the biomechanic properties of ruptured rat Achilles' tendon.
Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Captopril; Male; Neurotransmitter Agents; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rupture; Stress, Mechanical; Substance P; Thiorphan; Wound Healing | 2006 |
The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.
Topics: Antihypertensive Agents; Captopril; Cystine; Infrared Rays; Pharmaceutical Preparations; Photochemistry; Protease Inhibitors; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Synchrotrons; Thiorphan; Ultraviolet Rays; Vacuum | 2008 |
Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat.
Topics: Adrenomedullin; Aged; Angiotensin I; Arteries; Captopril; Female; Humans; Male; Middle Aged; Neprilysin; Protease Inhibitors; Pyridines; Substance P; Thiazepines; Thiorphan; Vasodilation | 2014 |
Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala.
Topics: Amygdala; Animals; Captopril; Electrical Synapses; Enkephalins; Glutamic Acid; Leucine; Male; Neprilysin; Protease Inhibitors; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiorphan | 2020 |
The Effects of One-Point Mutation on the New Delhi Metallo Beta-Lactamase-1 Resistance toward Carbapenem Antibiotics and β-Lactamase Inhibitors: An In Silico Systematic Approach.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Captopril; Carbapenems; Microbial Sensitivity Tests; Point Mutation; Thiorphan | 2022 |