Page last updated: 2024-08-23

captopril and spironolactone

captopril has been researched along with spironolactone in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (22.22)	18.7374
1990's	12 (16.67)	18.2507
2000's	26 (36.11)	29.6817
2010's	16 (22.22)	24.3611
2020's	2 (2.78)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Donker, AJ; Hackeng, WH; Meuwissen, SG; van Vliet, AA	1
de Caro, G; Epstein, AN; Gentili, L; Massi, M; Pompei, P	1
Capron, MH; Pelletier, B; Schohn, DC; Spiesser, R; Wehrlen, M	1
Bolli, P; Brouwer, RM; Bühler, FR; Conen, D; Erné, P; Kiowski, W	1
Christensen, P; Clementsen, P; Damkjaer, M; Giese, J; Hansen, CL; Høegholm, A	1
Brunkhorst, R; Koch, K; Kühn, K; Schmidt, FW; Wrenger, E	1
Bidiville, J; Brunner, HR; Mooser, V; Nussberger, J; Waeber, B; Waeber, G	1
Brest, AN	1
Epstein, AN; Massi, M	1
Crozier, IG; Ikram, H; Lewis, GR; Nicholls, MG; Richards, AM; Webster, MW	1
Epstein, AN; Nicolaïdis, S; Sakai, RR	1
Greminger, P; Groth, H; Stimpel, M; Vetter, H; Vetter, W	1
Garcia-Alves, M; Macieira-Coelho, E; Reis-Valle, A	1
Chatterjee, TK; Das, S; Ganguly, A; Ghosh, JJ	1
Moyer, JH	1
Arakawa, K; Kamei, H	1
Atkinson, AB; Brown, JJ; Davies, DL; Lever, AF; Robertson, JI	1
Carpenter, RG; Grossman, SP; Stamoutsos, BA	1
Brunner, HR; Burckhardt, P; Gavras, H; Waeber, B	1
Han, YL; Hu, XL; Jing, QM; Liu, JQ; Tong, M	1
Dubbelman, R; Kröger, R; Ten Bokkel-Huinink, WW; Van Vliet, AA	1
Jolobe, OM	1
Dahlström, U; Karlsson, E	1
Zannad, F	1
Koksch, M; Müller, J; Rühlmann, C; Wittig, K	1
Cserhalmi, L	1
Brown, L; Duce, B; Miric, G; Sernia, C	1
King, SR; Smeda, J; Vasdev, S	1
Armstrong, PW	1
Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ	1
Ferrari, P; Frey, FJ; Fuster, D	1
Epstein, M	1
Miller, AB; Srivastava, P	1
Farfel, Z; Kantor, R; Mayan, H	1
Casis, O; Echevarria, E; Espiña, L; Gallego, M; Iriarte, MM; Vegas, L	1
Felder, RB; Francis, J; Weiss, RM; Zhang, ZH	1
Frick, M; Gouya, G; Hügel, H; Pachinger, O; Pölzl, G; Ulmer, H	1
Bauer, JA; Ghosh, S; Holycross, BJ; Kambara, A; Kwiatkowski, P; McCune, SA; Schanbacher, B; Wung, P	1
Cohen-Solal, A; Dietz, R; Eichhorn, E; Erhardt, L; Hobbs, FD; Krum, H; Maggioni, A; McKelvie, RS; McMurray, J; Piña, IL; Soler-Soler, J; Swedberg, K	1
Hyjek, E; Jaggi, JS; McDevitt, MR; Scheinberg, DA; Seshan, SV; Sgouros, G	1
Hattori, T; Kase, Y; Maruyama, H; Nakai, Y; Nishimura, H; Sakakibara, I; Takeda, S	1
Capikova, D; Jendekova, L; Matuskova, J; Paulis, L; Pechanova, O; Simko, F	1
Fukushima Kusano, K; Hisamatsu, K; Ishihara, K; Kajiya, M; Miura, A; Miura, D; Miura, R; Morita, H; Nagase, S; Nakamura, K; Ohe, T	1
de Resende, MM; Greene, AS; Kriegel, AJ	1
Hoyer, RJ; Lacy, MQ; Leung, N; Witzig, TE	1
Billalabeitia, EG; Carmona-Bayonas, A; Díaz, MP; Gómez, FI; Saura, HP; Soler, IO; Tafalla, MS	1
CAO, ZX; DU, X; HOU, GS; LI, DX; LIU, FS; QI, RP; SONG, SM; WANG, GL; WANG, LG; WU, SL; XING, AJ; YU, Q	1
Blankesteijn, WM; Daemen, MJ; Fujimoto, A; Fujimoto, S; Hofstra, L; Isobe, S; Li, P; Lovhaug, D; Narula, J; Narula, N; Petrov, A; Pitt, B; Reutelingsperger, C; Smits, JF; van den Borne, SW; Vannan, MA; Wong, ND; Zandbergen, HR; Zannad, F	1
Adamcova, M; Bednarova, K; Krajcirovicova, K; Mullerova, M; Paulis, L; Pechanova, O; Pelouch, V; Simko, F	1
Johnson, AK; Morris, MJ; Na, ES	1
Purnamasari, D; Soebijanto, N	1
Cai, Y; Jia, LX; Qi, YF; Tang, CS; Wang, X; Wu, SY; Xiao, CS; Yu, YR	1
Akhtar, S; Al-Rashdan, I; Babiker, F; Benter, IF; Yousif, M	1
Adler, GK; Brown, JM; Garg, R; Garza, AE; Luther, JM; Pojoga, LH; Ruan, DT; Vaidya, A; Williams, GH; Williams, JS	1
Pilz, S; Tomaschitz, A	1
Adamcova, M; Krajcirovicova, K; Matuskova, J; Paulis, L; Pechanova, O; Pelouch, V; Simko, F	1
Alves, PH; Castro, CH; Colugnati, DB; Macedo, LM; Mendes, EP; Nunes, AD; Pedrino, GR; Santos, RA; Souza, AP	1
Balochnejadmojarrad, T; Chamani, E; Ebadi, Z; Fadaei, R; Fallah, S; Kazemi Fard, T; Moradi, N	1
Alizadeh-Fanalou, S; Chamani, E; Ebadi, Z; Fadaei, R; Fallah, S; Ghaffari, T; Moradi, N; Yarahmadi, S	1
Bao, M; Li, J; Song, Y; Wu, S	1

Reviews

7 review(s) available for captopril and spironolactone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Spironolactone in the treatment of hypertension: a review. Clinical therapeutics, 1986, Volume: 8, Issue:5 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Captopril; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Renin-Angiotensin System; Spironolactone	1986
Drug systems approach to hypertension. Pennsylvania medicine, 1984, Volume: 87, Issue:5 Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Methyldopa; Patient Compliance; Prazosin; Proteinuria; Renin-Angiotensin System; Reserpine; Spironolactone	1984
Angiotensin-converting enzyme inhibitor and spironolactone combination therapy. New objectives in congestive heart failure treatment. The American journal of cardiology, 1993, Jan-21, Volume: 71, Issue:3 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Captopril; Drug Therapy, Combination; Heart; Heart Failure; Humans; Spironolactone	1993
[Effect of combined captopril-spironolactone therapy of cardiac insufficiency on kidney function and serum electrolyte values]. Orvosi hetilap, 1998, Jan-11, Volume: 139, Issue:2 Topics: Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Failure; Humans; Kidney; Spironolactone; Water-Electrolyte Balance	1998
Aldosterone as a mediator of progressive renal disease: pathogenetic and clinical implications. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:4 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Eplerenone; Humans; Hypertension; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Spironolactone	2001
Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure. Cardiology clinics, 2001, Volume: 19, Issue:2 Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart Failure; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan	2001

Trials

7 trial(s) available for captopril and spironolactone

Article	Year
Aldactazine/captopril combination, safe and effective in mild to moderate systemic hypertension: report on a multicenter study of 967 patients. The American journal of cardiology, 1990, Jun-19, Volume: 65, Issue:23 Topics: Adolescent; Adult; Aged; Benzothiadiazines; Blood Pressure; Captopril; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Sodium Chloride Symporter Inhibitors; Spironolactone; Sulfonamides	1990
Antihypertensive treatment using calcium antagonists in combination with captopril rather than diuretics. Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 1 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Proline; Renin; Renin-Angiotensin System; Spironolactone; Verapamil	1985
Combined therapy of captopril and spironolactone for refractory congestive heart failure. Chinese medical journal, 1994, Volume: 107, Issue:9 Topics: Adult; Aged; Aldosterone; Captopril; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Middle Aged; Spironolactone	1994
Treatment of patients with IVCS and gross oedema and ascites with diuretic combination and ACE-inhibitors: relation to baseline PRA and PAC. The Netherlands journal of medicine, 1995, Volume: 46, Issue:2 Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Ascites; Captopril; Diuretics; Drug Therapy, Combination; Edema; Female; Furosemide; Humans; Male; Middle Aged; Renin; Spironolactone; Vascular Diseases; Vena Cava, Inferior	1995
[Impact of patient compliance on the outcomes in hypertensive patients receiving hydrochlorothiazide based combination therapy with spironolactone or captopril]. Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:12 Topics: Aged; Antihypertensive Agents; Captopril; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Spironolactone; Treatment Outcome	2008
Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:2 Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Captopril; Diuretics; Dose-Response Relationship, Drug; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Parathyroid Glands; Parathyroid Hormone; Renin-Angiotensin System; Spironolactone; Vasoconstrictor Agents; Vitamin D	2014
Influence of Hypersensitive C-Reactive Protein on the Effect of Continuous Antihypertensive Pharmacological Therapy. Journal of cardiovascular pharmacology, 2022, 07-01, Volume: 80, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; C-Reactive Protein; Captopril; Humans; Hydrochlorothiazide; Hypertension; Nitrendipine; Spironolactone	2022

Other Studies

58 other study(ies) available for captopril and spironolactone

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Efficacy of low-dose captopril in addition to furosemide and spironolactone in patients with decompensated liver disease during blunted diuresis. Journal of hepatology, 1992, Volume: 15, Issue:1-2 Topics: Adult; Aged; Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Captopril; Creatinine; Cyclic GMP; Diuresis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Humans; Kidney; Liver; Liver Cirrhosis; Male; Middle Aged; Renal Dialysis; Renin; Sodium; Spironolactone	1992
Central tachykinin injection potently suppresses the need-free salt intake of the female rat. Brain research, 1992, Jul-03, Volume: 584, Issue:1-2 Topics: Aldosterone; Angiotensin II; Animals; Captopril; Down-Regulation; Drinking; Eating; Eledoisin; Female; Injections, Intraperitoneal; Injections, Intraventricular; Kassinin; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium, Dietary; Spironolactone; Sucrose; Tachykinins	1992
Bartter's syndrome--treatment with potassium, spironolactone and ACE-inhibitor. Journal of internal medicine, 1989, Volume: 225, Issue:2 Topics: Adult; Bartter Syndrome; Captopril; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Potassium; Renin-Angiotensin System; Spironolactone	1989
[Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites]. Klinische Wochenschrift, 1989, Aug-01, Volume: 67, Issue:15 Topics: Adult; Aged; Ascites; Blood Pressure; Captopril; Diuresis; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Liver Cirrhosis; Male; Middle Aged; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Spironolactone; Water-Electrolyte Balance	1989
Kalemia during combined therapy with an angiotensin converting enzyme inhibitor and a potassium-sparing diuretic. Journal of clinical hypertension, 1987, Volume: 3, Issue:4 Topics: Adult; Captopril; Creatinine; Drug Therapy, Combination; Enalapril; Furosemide; Humans; Hypertension; Middle Aged; Potassium; Spironolactone	1987
The apparent dependence of salt appetite in the pigeon on endogenous angiotensin II. Physiology & behavior, 1987, Volume: 41, Issue:2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Appetite; Captopril; Columbidae; Drinking; Male; Receptors, Angiotensin; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sodium; Sodium Chloride; Spironolactone	1987
Combined spironolactone and converting-enzyme inhibitor therapy for refractory heart failure. Australian and New Zealand journal of medicine, 1986, Volume: 16, Issue:1 Topics: Adult; Captopril; Diuresis; Drug Therapy, Combination; Enalapril; Female; Heart Failure; Humans; Male; Middle Aged; Oligopeptides; Spironolactone; Teprotide	1986
Salt appetite is suppressed by interference with angiotensin II and aldosterone. The American journal of physiology, 1986, Volume: 251, Issue:4 Pt 2 Topics: Aldosterone; Angiotensin II; Animals; Appetite; Captopril; Cerebral Ventricles; Insulin; Male; Natriuresis; Rats; Rats, Inbred Strains; Sodium Chloride; Spironolactone	1986
Captopril before and after spironolactone therapy in primary aldosteronism. Pathogenetic and therapeutical aspects. Klinische Wochenschrift, 1985, Apr-15, Volume: 63, Issue:8 Topics: Aldosterone; Blood Pressure; Captopril; Drug Therapy, Combination; Humans; Hypertension; Potassium; Proline; Renin; Spironolactone	1985
Essential hypertension: a metabolic cause? A hypothesis. Angiology, 1985, Volume: 36, Issue:5 Topics: Adult; Aged; Aldosterone; Blood Pressure; Calcium; Captopril; Female; Humans; Hydrochlorothiazide; Hypertension; Lactates; Lactic Acid; Male; Middle Aged; Potassium; Potassium Chloride; Propranolol; Renin; Spironolactone	1985
Role of adrenal steroids on electroacupuncture analgesia and on antagonising potency of naloxone. Pain, 1984, Volume: 18, Issue:2 Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Angiotensin II; Animals; Captopril; Desoxycorticosterone; Dexamethasone; Electric Stimulation Therapy; Male; Mineralocorticoids; Naloxone; Rats; Spironolactone; Time Factors; Transcutaneous Electric Nerve Stimulation	1984
A case of pseudoaldosteronism due to addiction of Jintan, a mouth refresher popular among Japanese. Japanese heart journal, 1982, Volume: 23, Issue:4 Topics: Captopril; Glycyrrhetinic Acid; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Middle Aged; Renin; Spironolactone; Substance-Related Disorders	1982
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. Clinical endocrinology, 1981, Volume: 14, Issue:1 Topics: Adult; Angiotensin II; Captopril; Drug Therapy, Combination; Humans; Hyperaldosteronism; Hypertension; Kidney Failure, Chronic; Male; Proline; Sodium; Spironolactone	1981
Role of angiotensin-II in the polydipsia of diabetes insipidus in the Brattleboro rat. Physiology & behavior, 1981, Volume: 26, Issue:4 Topics: Angiotensin II; Animals; Captopril; Diabetes Insipidus; Drinking; Furosemide; Male; Quinine; Rats; Rats, Inbred Strains; Spironolactone	1981
Hypertension in a patient with hypercalcemia: captopril and verapamil. Archives of internal medicine, 1982, Volume: 142, Issue:1 Topics: Adult; Captopril; Drug Therapy, Combination; Female; Humans; Hypercalcemia; Hyperparathyroidism; Hypertension; Proline; Spironolactone; Verapamil	1982
Efficacy of low-dose captopril in addition to furosemide and spironolactone in patients with decompensated liver disease during blunted diuresis. Journal of hepatology, 1993, Volume: 19, Issue:2 Topics: Aged; Captopril; Diuresis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide; Humans; Kidney; Liver Diseases; Spironolactone	1993
Captopril and spironolactone therapy for refractory congestive heart failure. The American journal of cardiology, 1993, Jan-21, Volume: 71, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Captopril; Drug Therapy, Combination; Female; Heart Failure; Humans; Kidney; Male; Middle Aged; Potassium; Sodium; Spironolactone	1993
[Aneurysm of the ascending aorta in tertiary syphilis]. Deutsche medizinische Wochenschrift (1946), 1996, Apr-26, Volume: 121, Issue:17 Topics: Angiotensin-Converting Enzyme Inhibitors; Antitussive Agents; Aortic Aneurysm, Thoracic; Aortic Valve Insufficiency; Captopril; Codeine; Diuretics; Drug Therapy, Combination; Echocardiography; Fatal Outcome; Furosemide; Humans; Male; Middle Aged; Paraffin; Spironolactone; Syphilis; Syphilis Serodiagnosis; Tomography, X-Ray Computed	1996
Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. Journal of the American Society of Nephrology : JASN, 1999, Volume: 10 Suppl 11 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Collagen; Desoxycorticosterone; Endomyocardial Fibrosis; Fibronectins; Heart; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium, Dietary; Spironolactone; Tetrazoles	1999
Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Captopril; Cerebral Hemorrhage; Dexamethasone; Drug Interactions; Hydralazine; Hypertension; Male; Rats; Rats, Inbred SHR; Spironolactone; Stroke; Survival Rate; Time Factors	1999
Left ventricular dysfunction: causes, natural history, and hopes for reversal. Heart (British Cardiac Society), 2000, Volume: 84 Suppl 1 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Coronary Disease; Female; Heart; Heart Failure; Humans; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Randomized Controlled Trials as Topic; Spironolactone; Ventricular Dysfunction, Left; Ventricular Remodeling	2000
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles	2001
[Dangerous hyperkalemia as sequelae of new treatment strategies of heart failure]. Praxis, 2000, Dec-07, Volume: 89, Issue:49 Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Drug Therapy, Combination; Heart Failure; Humans; Hyperkalemia; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Risk Factors; Spironolactone	2000
Trans-tubular potassium gradient in patients with drug-induced hyperkalemia. Nephron, 2001, Volume: 89, Issue:1 Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Captopril; Creatinine; Female; Humans; Hyperkalemia; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Potassium; Renal Insufficiency; Spironolactone; Uremia	2001
Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats. Pharmacological research, 2001, Volume: 44, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cardiomegaly; Collagen; Dose-Response Relationship, Drug; Endomyocardial Fibrosis; Heart Ventricles; Isoproterenol; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Spironolactone; Ventricular Remodeling	2001
The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failure. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:1 Topics: Action Potentials; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; Heart Failure; Injections, Intra-Arterial; Injections, Intravenous; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Ischemia; Neurons; Paraventricular Hypothalamic Nucleus; Pressoreceptors; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Spironolactone	2002
[Adaptation of guidelines for the treatment of chronic heart failure in a specialized heart failure clinic]. Wiener klinische Wochenschrift, 2002, Oct-31, Volume: 114, Issue:19-20 Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Austria; Bisoprolol; Captopril; Cardiac Care Facilities; Data Interpretation, Statistical; Diuretics; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Neurotransmitter Agents; Practice Guidelines as Topic; Regression Analysis; Spironolactone; Stroke Volume	2002
Combined effects of low-dose oral spironolactone and captopril therapy in a rat model of spontaneous hypertension and heart failure. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:6 Topics: Administration, Oral; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Diuresis; Drug Therapy, Combination; Fibrosis; Heart Failure; Heart Ventricles; Hypertension; Hypertrophy; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Rats; Rats, Inbred SHR; Spironolactone; Time Factors; Ultrasonography	2003
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice. European journal of heart failure, 2005, Volume: 7, Issue:5 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Benzopyrans; Biphenyl Compounds; Bisoprolol; Captopril; Carbazoles; Carvedilol; Drug Therapy, Combination; Enalapril; Ethanolamines; Evidence-Based Medicine; Guideline Adherence; Heart Failure; Humans; Indoles; Lisinopril; Metoprolol; Mineralocorticoid Receptor Antagonists; Nebivolol; Practice Guidelines as Topic; Propanolamines; Ramipril; Spironolactone; Stroke Volume; Tetrazoles; Valine; Valsartan	2005
Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. International journal of radiation oncology, biology, physics, 2006, Apr-01, Volume: 64, Issue:5 Topics: Actinium; Alpha Particles; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Urea Nitrogen; Captopril; Female; Imidazoles; Kidney; Kidney Tubules; Mice; Mice, Inbred BALB C; Mineralocorticoid Receptor Antagonists; Radiation Dosage; Radiation Injuries, Experimental; Radiation-Protective Agents; Random Allocation; Spironolactone; Tetrazoles	2006
Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats. Clinical and experimental nephrology, 2006, Volume: 10, Issue:1 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Autoantibodies; Captopril; Diuretics; Drugs, Chinese Herbal; Edema; Furosemide; Humans; Japan; Male; Mice; Nephritis; Oleanolic Acid; Potassium; Random Allocation; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Saponins; Sodium; Spironolactone	2006
Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats. Kidney international, 2006, Volume: 70, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Enzyme Inhibitors; Hypertension, Renal; Kidney; Male; Mineralocorticoid Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; S-Nitrosothiols; Spironolactone	2006
Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells. Journal of pharmacological sciences, 2006, Volume: 101, Issue:3 Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Male; Mineralocorticoid Receptor Antagonists; Spironolactone; Tetrazoles; Tumor Necrosis Factor-alpha	2006
Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. Journal of cardiovascular pharmacology, 2006, Volume: 48, Issue:6 Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Echocardiography; Injections, Subcutaneous; Myocardium; Organ Size; Random Allocation; Rats; Rats, Inbred Strains; Spironolactone; Ventricular Function, Left; Weight Loss	2006
Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis. American journal of hematology, 2007, Volume: 82, Issue:5 Topics: Amyloidosis; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Captopril; Chest Tubes; Combined Modality Therapy; Dexamethasone; Diuretics; Drug Resistance; Edema; Fatal Outcome; Furosemide; Humans; Hypoalbuminemia; Male; Melphalan; Metolazone; Middle Aged; Multiple Myeloma; Nephrotic Syndrome; Peripheral Blood Stem Cell Transplantation; Pleural Effusion; Prednisolone; Serum Albumin; Spironolactone; Thalidomide; Thoracostomy; Transplantation, Autologous; Vascular Endothelial Growth Factor A	2007
Tailored hormonal therapy in secretory adrenocortical cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:7 Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Antifungal Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Captopril; Cisplatin; Diarrhea; Doxorubicin; Etoposide; Female; Heart Failure; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypokalemia; Ketoconazole; Mineralocorticoid Receptor Antagonists; Mitotane; Neoplasm Recurrence, Local; Potassium; Rhabdomyolysis; Spironolactone; Tachycardia	2007
Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling. JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:2 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Carbocyanines; Cardiovascular Agents; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Fibrillar Collagens; Fibroblasts; Fibrosis; Losartan; Mice; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Oligopeptides; Predictive Value of Tests; Spironolactone; Technetium; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left; Ventricular Remodeling	2009
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 2009, Volume: 27, Issue:6 Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Captopril; Hypertrophy, Left Ventricular; Kidney; Male; Melatonin; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin; Spironolactone; Ventricular Remodeling	2009
Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite. Behavioral neuroscience, 2010, Volume: 124, Issue:2 Topics: Aldosterone; Animals; Appetite; Captopril; Desoxycorticosterone; Drug Interactions; Furosemide; Hyponatremia; Hypothalamic Area, Lateral; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Potassium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin; Renin-Angiotensin System; Reward; Self Stimulation; Sodium; Spironolactone	2010
The difficulty of medical management of Cushing disease. Acta medica Indonesiana, 2011, Volume: 43, Issue:2 Topics: Amlodipine; Antihypertensive Agents; Captopril; Clonidine; Female; Humans; Mineralocorticoid Receptor Antagonists; Pituitary ACTH Hypersecretion; Potassium; Spironolactone; Young Adult	2011
Endogenous aldosterone is involved in vascular calcification in rat. Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:1 Topics: Aldosterone; Alkaline Phosphatase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Calcium; Captopril; Cholecalciferol; Collagen; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Nicotine; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Vascular Calcification	2012
RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes. Journal of diabetes research, 2013, Volume: 2013 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Heart; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Spironolactone	2013
Interplay between sodium and calcium regulatory hormones: a clinically relevant research field. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:2 Topics: Angiotensin II; Captopril; Female; Humans; Hypertension; Male; Parathyroid Hormone; Renin-Angiotensin System; Spironolactone	2014
Effects of captopril, spironolactone, and simvastatin on the cardiovascular system of non-diseased Wistar rats. International journal of cardiology, 2015, Volume: 190 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Simvastatin; Spironolactone; Ventricular Remodeling	2015
Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017, Mar-23, Volume: 50, Issue:4 Topics: Amlodipine; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Abdominal; Blood Pressure; Calcium Channel Blockers; Captopril; Coronary Vessels; Losartan; Male; Mineralocorticoid Receptor Antagonists; Models, Animal; Peptide Fragments; Rats, Wistar; Reproducibility of Results; Spironolactone; Time Factors; Vasoconstriction; Vasodilation	2017
Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c. DNA and cell biology, 2019, Volume: 38, Issue:10 Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Urea Nitrogen; Captopril; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diuretics; Drug Combinations; Drug Repositioning; Gene Expression Regulation; Hyperglycemia; Hypoglycemic Agents; Male; MicroRNAs; Rats; Rats, Wistar; Spironolactone; Streptozocin; Transforming Growth Factor beta; Treatment Outcome	2019
Captopril and Spironolactone can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting ABCA1 and microRNA-33. Current pharmaceutical design, 2022, Volume: 28, Issue:16 Topics: Animals; ATP Binding Cassette Transporter 1; Captopril; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; MicroRNAs; Rats; Rats, Wistar; Spironolactone	2022