captopril has been researched along with enalaprilat anhydrous in 133 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (34.59) | 18.7374 |
| 1990's | 64 (48.12) | 18.2507 |
| 2000's | 15 (11.28) | 29.6817 |
| 2010's | 7 (5.26) | 24.3611 |
| 2020's | 1 (0.75) | 2.80 |
| Authors | Studies |
|---|---|
| Barton, J; Bruno, JG; Calvo, RR; Kornberg, BE; Menard, PR; Mencel, JJ; Neiss, ES; Regan, JR; Schwab, A; Suh, JT | 1 |
| Baum, T; Gold, EH; McNamara, P; Neustadt, BR; Smith, EM; Swiss, GF; Sybertz, EJ | 1 |
| Cushman, DW; DeForrest, JM; Duggan, M; Karanewsky, DS; Krapcho, J; Powell, JR; Rovnyak, G; Schwartz, J; Spitzmiller, ER; Turk, C | 1 |
| Allibone, PL; Greenlee, WJ; Patchett, AA; Perlow, DS; Ulm, EH; Vassil, TC | 1 |
| Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ | 1 |
| Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE | 1 |
| Bennett, LR; Blankley, CJ; Bobowski, G; DeJohn, DE; Hoefle, ML; Johnson, DR; Kaltenbronn, JS; Krolls, U; Pearlman, WM; Werner, A | 1 |
| Badia, MC; Cushman, DW; DeForrest, JM; Dejneka, T; Karanewsky, DS; Loots, MJ; Perri, MG; Petrillo, EW; Powell, JR | 1 |
| Berry, CJ; Fink, CA; Ghai, RD; Qiao, Y; Sakane, Y; Trapani, AJ | 1 |
| Crippen, GM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Codd, R; Gotsbacher, MP; Roth, L | 1 |
| Auch-Schwelk, W; Bossaller, C; Claus, M; Fleck, E; Graf, K; Gräfe, M | 1 |
| Hooper, NM; Hryszko, J; Oppong, SY; Turner, AJ | 1 |
| Elliott, HL; Hughes, DM; Meredith, PA; Wade, JR | 1 |
| Alhenc-Gelas, F; Clauser, E; Corvol, P; Wei, L | 2 |
| Hashimoto, Y; Kubo, M; Minobe, S; Sugaya, T; Taniguchi, T; Watanabe, T | 1 |
| Andrawis, NS; Dzau, VJ; Pratt, RE | 1 |
| Chin, SA; Fawcett, JP; Walker, RJ | 1 |
| Auch-Schwelk, W; Baumgarten, C; Bossaller, C; Fleck, E; Graf, K; Gräfe, M | 1 |
| Silldorff, EP; Stephens, GA | 1 |
| Nelissen-Vrancken, HJ; Smits, JF; Struijker-Boudier, HA | 1 |
| Goldschmidt, JE; Tallarida, RJ | 1 |
| Cushman, DW; Dzwonczyk, S; Fung, W; Grover, GJ; Sleph, PG; Tobias, D; Wang, P | 1 |
| Cassidy, MM; Freedman, AM; Weglicki, WB | 1 |
| Criscuoli, M; Guelfi, M; Subissi, A | 1 |
| Anderson, BA; Dage, RC; Koerner, JE | 1 |
| Lawson, DL; Mehta, JL; Mehta, P; Nichols, WW | 1 |
| Mollace, V; Salvemini, D; Sessa, WC; Vane, JR | 1 |
| Kloner, RA; Przyklenk, K | 1 |
| Lawson, DL; Mehta, JL; Saldeen, K | 1 |
| Hess, ML; Kontos, HA; Kukreja, RC | 1 |
| Iijima, M; Kajiwara, Y; Kitabatake, K; Matsui, S; Saito, S; Shirota, M; Waga, T; Watanabe, M | 1 |
| Hiwada, K; Inoue, Y; Kokubu, T | 1 |
| Iijima, M; Kajiwara, Y; Kitabatake, K; Shirota, M | 1 |
| Dietze, GJ; Rett, K; Tio, RA; van Gilst, WH; Wesseling, H; Wolters, K | 1 |
| Bennett, T; Compton, AM; Gardiner, SM; Muller, AF | 1 |
| Bunnett, NW; Orloff, MS; Turner, AJ | 1 |
| Dabbeni-Sala, F; Finotti, P; Palatini, P | 1 |
| Beierwaltes, WH; Carretero, OA | 1 |
| de Langen, CD; Scholtens, E; Tio, RA; van Gilst, WH; van Wijngaarden, J; Wesseling, H | 1 |
| Brinck-Johnsen, T; Colpoys, MC; Conrad, KP; Morganelli, PM | 1 |
| Abe, K; Fang, SN; Kanazawa, M; Kasai, Y; Omata, K; Sato, M; Takeuchi, K; Yasujima, M; Yoshinaga, K | 1 |
| de Langen, CD; Heiligers, JP; König, W; Saxena, PR; Tio, RA; van Gilst, WH; Wesseling, H | 1 |
| Kubo, T; Misu, Y; Shionoiri, H; Yasuda, G | 1 |
| Bendhack, LM; Lindsey, CJ; Paiva, AC | 1 |
| Bicknell, R; Holmquist, B; Lee, FS; Martin, MT; Riordan, JF | 1 |
| Dale, DC; Hammond, WP; Miller, JE; Rosenthal, AS; Starkebaum, G; Zweerink, HJ | 1 |
| Gordon, RD; Hamlet, SM; Klemm, SA; Tunny, TJ | 1 |
| Goering, JL; Raich, PC; Zimmerman, BG | 1 |
| Denton, DA; Di Nicolantonio, R; McKinley, MJ; Weisinger, RS | 1 |
| Bull, HG; Cordes, EH; Cordes, MH; Patchett, AA; Thornberry, NA | 1 |
| Castillo, GA; Orce, GG | 1 |
| Cordes, EH; Patchett, AA | 1 |
| Autry, WL; Barbaz, BS; Norman, JA | 1 |
| Hidaka, H; Oka, H; Sato, R; Sawada, S; Yasuda, Y | 1 |
| Snyder, SH; Strittmatter, SM | 1 |
| Buckner, FS; Chen, FN; Ganong, WF; Wade, CE | 1 |
| Chadwick, B; Le Jemtel, TH; Maskin, CS | 1 |
| de Deus, RB; Henriques, OB; Santos, RA | 1 |
| Chung, AY; Ryan, JW | 1 |
| Berryer, P; Hart, MA; Ryan, JW; Ryan, US | 1 |
| Itaya, Y; Kumagai, H; Matsukawa, S; Saruta, T; Suzuki, H | 1 |
| Atlas, SA; Case, DB; Cody, RJ; Laragh, JH | 1 |
| Gaul, SL; Martin, GE; Sweet, CS | 1 |
| Davies, RO; Irvin, JD; Kramsch, DK; Moncloa, F; Walker, JF | 1 |
| Riordan, JF; Shapiro, R | 2 |
| Casley, D; Cubella, R; Jackson, BJ; Johnston, CI; Larmour, I | 1 |
| Schacht, U | 1 |
| Berecek, KH; Nagahama, S; Oparil, S | 1 |
| Coghlan, JP; Denton, DA; Fei, DT; Nelson, MA; Scoggins, BA; Stewart, KW | 1 |
| Bull, HG; Cascieri, MA; Liang, T; Mumford, RA; Patchett, AA; Thornberry, NA | 1 |
| Backlund, EP; Bohn, DL; Gross, DM; Morris, AA; Stone, CA; Sweet, CS; Ulm, EH; Vassil, TC; Weitz, D; Wenger, HC | 1 |
| Galluzzo, TS; Gardner, DV; Molteni, A; Ts'ao, C | 1 |
| Ikeda, U; Shimada, K | 1 |
| Davies, MK | 1 |
| Clapperton, M; Dargie, HJ; Fisher, AC; McMurray, J | 1 |
| Miselis, J; Siminiak, T; Wysocki, H | 1 |
| Andersson, KE; Hedlund, H; Lindberg, BF; Nilsson, LG; Stahl, M | 1 |
| Manso, CF; Mira, ML; Silva, MM | 1 |
| Garrison, EA; Kadowitz, PJ; Santiago, JA | 1 |
| Emith, AE; Jameison, FA; Lindner, HJ; Ojima, I; Pete, B; Radunz, H; Schittenhelm, C | 1 |
| Carbonell, LF; Inglés, AC; Quesada, T; Ruiz, FJ; Salom, MG; Vicente, E | 1 |
| Feng, CJ; Kadowitz, PJ; Nossaman, BD; Wang, J | 1 |
| Manso, CF; Mira, ML; Queiroz, MJ; Silva, MM | 1 |
| Mehring, N; Neusser, M; Tepel, M; Zhu, Z; Zidek, W | 1 |
| Homeister, JW; Kilgore, KS; Lucchesi, BR; Satoh, PS | 1 |
| Andreoli, SP | 1 |
| Blaufox, MD; Nally, JV; Sheps, SG; Textor, SC | 1 |
| Mimran, A; Nafrialdi, N; Ribstein, J; Valentin, JP | 1 |
| Bumpus, FM; Husain, A; Kinoshita, A; Urata, H | 1 |
| Lees, KR; MacFadyen, RJ; Reid, JL; Squire, IB | 2 |
| Abdullah, I; Beswick, PH; Clapperton, M; Dargie, HJ; Fisher, AC; McMurray, J | 1 |
| Rehm, PK | 1 |
| Friedman, M; Piana, RN; Sellke, FW; Wang, SY | 1 |
| Bagger-Sjöbäck, D; Ekborn, A; Lundblad, L | 1 |
| Bevilacqua, M; Conci, F; Norbiato, G; Rogolino, A; Santoli, E; Vago, T | 1 |
| Crandall, ME; Heesch, CM; Turbek, JA | 1 |
| Hintze, TH; Nasjletti, A; Wolin, MS; Xie, YW; Xu, X; Zhang, X | 1 |
| Moore, JN; Tillman, LG | 1 |
| Androulakis, AE; Dernellis, J; Gialafos, JE; Kelepeshis, GA; Kyriakidis, M; Mellas, P; Triposkiadis, F | 1 |
| Gu, PK; Jin, ZJ; Qi, JH; Wang, J; Wei, PJ; Zhang, L; Zhang, PJ | 1 |
| Andrade, MC; Boim, MA; Carmona, AK; Casarini, DE; Quinto, BM; Ribas, OS; Schor, N | 1 |
| Bedarida, GV; Blaschke, TF; Chalon, S; Hoffman, BB; Moreno, H; Tejura, B; Urae, A | 1 |
| Jin, ZJ; Qi, JH; Wang, J; Wei, PJ; Zhang, L; Zhang, PJ | 1 |
| Driscoll, WJ; Mueller, GP; Mueller, SA | 1 |
| Booker, PD; Davis, AJ; Diver, MJ; Whitehead, CF | 1 |
| Baudin, B; Bénéteau-Burnat, B | 1 |
| Janssen, BJ; Oosting, J; Struijker-Boudier, HA | 1 |
| Andersson, RG; Glindell, M; Jacobsson-Strier, M; Nyhlén, K; Persson, K; Whiss, PA | 1 |
| Taylor, A | 1 |
| Blais, PA; Gobeil, F; Hallé, S; Regoli, D | 1 |
| Erinola, M; Tepel, M; van der Giet, M; Zidek, W | 1 |
| Baudin, B; Deslandes, B; Mailloux, A; Vaubourdolle, M | 1 |
| Acharya, KR; Evans, HR; Natesh, R; Schwager, SL; Sturrock, ED | 1 |
| Andújar-Sánchez, M; Cámara-Artigas, A; Jara-Pérez, V | 1 |
| Boggi, U; Bugliani, M; Del Guerra, S; Del Prato, S; Lupi, R; Marchetti, P; Mosca, F; Torri, S | 1 |
| Bussink, M; Menheere, PP; van der Kuy, PH; van Mook, WN; van Onzenoort, HA | 1 |
| Liu, LY; Liu, YH; Song, T; Wu, SJ; You, Y | 1 |
| Alves Correa, SA; Camargo de Andrade, MC; Casarini, DE; Mortara, RA; Pesquero, JB; Redublo Quinto, BM; Ronchi, FA; Santos, EL; Shimuta, SI | 1 |
| Kashiwagi, Y; Kubota, S; Obata, T; Takahashi, S | 1 |
| Komano, H; Liu, J; Liu, S; Maeda, T; Michikawa, M; Oba, R; Satoh, Y; Watanabe, A; Zou, K | 1 |
| Gordon, RD; Stowasser, M; Wolley, M | 1 |
| Ahmed, AH; Cowley, D; Gordon, RD; Goupil, R; Stowasser, M; Wolley, M | 1 |
5 review(s) available for captopril and enalaprilat anhydrous
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The design and properties of N-carboxyalkyldipeptide inhibitors of angiotensin-converting enzyme.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Brain; Captopril; Carboxypeptidases; Carboxypeptidases A; Catalysis; Dipeptides; Enalaprilat; Humans; Kinetics; Models, Molecular; Oligopeptides; Peptidyl-Dipeptidase A; Protein Binding; Renin; Structure-Activity Relationship; Thermolysin | 1985 |
Enalapril worldwide experience.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Cell Count; Blood Pressure; Captopril; Dipeptides; Drug Evaluation; Drug Therapy, Combination; Enalapril; Enalaprilat; Humans; Hydrochlorothiazide; Hypertension; Peptidyl-Dipeptidase A; Posture; Propranolol; Renin-Angiotensin System | 1984 |
Effects of ACE inhibitors on coronary haemodynamics and angina pectoris.
Topics: Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Captopril; Coronary Disease; Enalaprilat; Hemodynamics; Humans; Hypertension; Myocardial Infarction | 1994 |
Functional testing: ACEI renography.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Costs and Cost Analysis; Enalaprilat; Humans; Hypertension, Renovascular; Radioisotope Renography; Radiopharmaceuticals; Renal Artery Obstruction; Sensitivity and Specificity | 2000 |
4 trial(s) available for captopril and enalaprilat anhydrous
| Article | Year |
|---|---|
The effect of saturation of ACE binding sites on the pharmacokinetics of enalaprilat in man.
Topics: Adult; Analysis of Variance; Binding Sites; Captopril; Double-Blind Method; Enalapril; Enalaprilat; Humans; Male; Peptidyl-Dipeptidase A; Random Allocation | 1992 |
Blood pressure response to the first dose of angiotensin-converting enzyme inhibitors in congestive heart failure.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Double-Blind Method; Enalapril; Enalaprilat; Female; Heart Failure; Humans; Indoles; Male; Middle Aged; Perindopril; Prodrugs | 1993 |
Angiotensin-converting enzyme inhibitors in heart failure: blood pressure changes after the first dose.
Topics: Acetylcholinesterase; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Double-Blind Method; Enalapril; Enalaprilat; Female; Heart Failure; Humans; Indoles; Male; Middle Aged; Perindopril | 1993 |
Effects of cardiac versus circulatory angiotensin-converting enzyme inhibition on left ventricular diastolic function and coronary blood flow in hypertrophic obstructive cardiomyopathy.
Topics: Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiomyopathy, Hypertrophic; Coronary Circulation; Diastole; Echocardiography; Enalaprilat; Female; Heart; Hemodynamics; Humans; Infusions, Parenteral; Male; Middle Aged; Prospective Studies; Ventricular Dysfunction, Left | 1998 |
124 other study(ies) available for captopril and enalaprilat anhydrous
| Article | Year |
|---|---|
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzothiadiazines; Dipeptides; Diuretics; Drug Design; Enalaprilat; Male; Rats; Sodium Chloride Symporter Inhibitors | 1990 |
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Chemical Phenomena; Chemistry; Dogs; Enalapril; Male; Phenylbutyrates; Rats; Rats, Inbred Strains; Spiro Compounds | 1989 |
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Enalapril; Enalaprilat; Kinetics; Male; Phosphinic Acids; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Enalapril; Enzyme Inhibitors; Structure-Activity Relationship | 1985 |
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines | 1985 |
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines | 1986 |
Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids.
Topics: Amino Acids; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enzyme Inhibitors; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship | 1987 |
(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Indicators and Reagents; Lung; Magnetic Resonance Spectroscopy; Male; Optical Rotation; Organophosphorus Compounds; Proline; Rabbits; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Dipeptides; Magnetic Resonance Spectroscopy; Male; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Thiorphan; Tryptophan | 1995 |
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin | 1997 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors.
Topics: Chromatography, Affinity; Coordination Complexes; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imino Acids; Metalloproteins; Metals, Heavy; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2020 |
Local potentiation of bradykinin-induced vasodilation by converting-enzyme inhibition in isolated coronary arteries.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Bradykinin; Captopril; Cattle; Coronary Vessels; Dipeptides; Enalaprilat; Endothelium, Vascular; Fosinopril; Humans; In Vitro Techniques; Lisinopril; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Ramipril; Receptors, Bradykinin; Receptors, Neurotransmitter; Vasodilation; Vasodilator Agents | 1992 |
Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Enalaprilat; Kidney; Metalloendopeptidases; Swine; Zinc | 1992 |
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Captopril; Chlorides; CHO Cells; Cricetinae; Enalapril; Enalaprilat; Humans; Indoles; Kinetics; Lisinopril; Mutation; Peptidyl-Dipeptidase A | 1992 |
[Studies on angiotensin I converting enzyme (ACE) inhibitory effect of imidapril. (I). Inhibition of various tissue ACEs in vitro].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Brain; Captopril; Enalaprilat; Humans; Imidazoles; Imidazolidines; In Vitro Techniques; Kidney; Lung; Male; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Swine | 1992 |
Autocrine stimulation of mas oncogene leads to altered growth control.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; 3T3 Cells; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Calcium; Captopril; Cell Line, Transformed; Cell Transformation, Neoplastic; Contact Inhibition; DNA Replication; Enalaprilat; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Oncogenes; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Recombinant Proteins | 1992 |
Captopril does not protect against renal oxidative injury.
Topics: Acetylcysteine; Animals; Captopril; Drug Interactions; Enalaprilat; Glutathione; Kidney; Lipid Peroxidation; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Time Factors | 1992 |
Effects of converting enzyme inhibition on endothelial bradykinin metabolism and endothelium-dependent vascular relaxation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Cattle; Cells, Cultured; Coronary Vessels; Dipeptides; Enalaprilat; Endothelium, Vascular; Humans; In Vitro Techniques; Isometric Contraction; Kinetics; Lisinopril; Vasodilation | 1992 |
Effects of converting enzyme inhibition and alpha receptor blockade on the angiotensin pressor response in the American alligator.
Topics: Adrenergic alpha-Antagonists; Alligators and Crocodiles; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Enalaprilat; Norepinephrine; Phenoxybenzamine; Phentolamine | 1992 |
Renal hemodynamic effects of nonhypotensive doses of angiotensin-converting enzyme inhibitors in hypertension and heart failure rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cardiac Output; Enalaprilat; Heart Failure; Hemodynamics; Hypertension; Injections, Intravenous; Male; Myocardial Infarction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Vascular Resistance | 1992 |
Pharmacological evidence that captopril possesses an endothelium-mediated component of vasodilation: effect of sulfhydryl groups on endothelium-derived relaxing factor.
Topics: Acetylcholine; Acetylcysteine; Animals; Captopril; Cyclic GMP; Enalaprilat; Endothelium, Vascular; Glutathione; In Vitro Techniques; Nitric Oxide; Norepinephrine; Pyrogallol; Rabbits; Structure-Activity Relationship; Sulfhydryl Compounds; Superoxide Dismutase; Tiopronin; Vasodilation | 1991 |
Effects of different angiotensin-converting enzyme (ACE) inhibitors on ischemic isolated rat hearts: relationship between cardiac ACE inhibition and cardioprotection.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Coronary Disease; Drug Stability; Enalaprilat; Fosinopril; Heart; In Vitro Techniques; Male; Myocardium; Organophosphorus Compounds; Prodrugs; Proline; Pyrroles; Ramipril; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1991 |
Captopril protects against myocardial injury induced by magnesium deficiency.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Captopril; Cardiomyopathies; Cricetinae; Diagnosis, Computer-Assisted; Enalaprilat; Magnesium Deficiency; Male; Myocardium | 1991 |
Angiotensin converting enzyme inhibitors potentiate the bronchoconstriction induced by substance P in the guinea-pig.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bronchi; Capsaicin; Captopril; Drug Synergism; Enalaprilat; Guinea Pigs; In Vitro Techniques; Male; Neuropeptides; Prazosin; Serotonin; Substance P | 1990 |
Protection against postischemic myocardial dysfunction in anesthetized rabbits with scavengers of oxygen-derived free radicals: superoxide dismutase plus catalase, N-2-mercaptopropionyl glycine and captopril.
Topics: Anesthesia; Animals; Blood Pressure; Captopril; Catalase; Enalaprilat; Endotoxins; Female; Free Radical Scavengers; Heart Rate; Myocardial Reperfusion Injury; Oxygen; Rabbits; Superoxide Dismutase; Tiopronin; Ventricular Function, Left | 1991 |
Captopril-induced reversal of nitroglycerin tolerance: role of sulfhydryl group vs. ACE-inhibitory activity.
Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Captopril; Cyclic GMP; Drug Tolerance; Enalaprilat; Nitroglycerin; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Vasodilation | 1991 |
Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols.
Topics: Acetylcysteine; Blood Platelets; Captopril; Drug Synergism; Enalaprilat; Endothelium, Vascular; Humans; Iloprost; Nitric Oxide; Nitroprusside; Nucleotides, Cyclic; Platelet Aggregation Inhibitors; Sulfhydryl Compounds; Teprotide; Thrombin | 1991 |
Angiotensin converting enzyme inhibitors improve contractile function of stunned myocardium by different mechanisms of action.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Captopril; Coronary Circulation; Dogs; Enalaprilat; Indomethacin; Myocardial Contraction; Myocardial Reperfusion Injury; Prostaglandins; Sulfhydryl Compounds | 1991 |
Angiotensin converting enzyme inhibitors potentiate the vasorelaxant effect of fibrinogen-derived peptide 6A.
Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Captopril; Drug Synergism; Enalaprilat; Fibrin Fibrinogen Degradation Products; In Vitro Techniques; Molecular Sequence Data; Rats; Vasodilation | 1991 |
The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.
Topics: Amino Acid Sequence; Angiotensin I; Animals; Captopril; Catalysis; Chlorides; Cricetinae; Cricetulus; DNA Mutational Analysis; Enalaprilat; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Peptidyl-Dipeptidase A; Recombinant Proteins; Structure-Activity Relationship | 1991 |
Captopril and enalaprilat do not scavenge the superoxide anion.
Topics: Captopril; Cytochrome c Group; Enalaprilat; Epinephrine; Fumarates; Humans; Nitroblue Tetrazolium; Oxidation-Reduction; Superoxides | 1990 |
Synthesis and angiotensin converting enzyme inhibitory activity of N-carboxymethyldipeptides with omega-(4-piperidyl)alkyl group.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Enalaprilat; In Vitro Techniques; Lung; Male; Piperidines; Rabbits; Rats; Rats, Inbred WKY | 1990 |
Effect of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, on the activity of angiotensin converting enzyme from human kidney.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalapril; Enalaprilat; Humans; Kidney; Kinetics; Organophosphorus Compounds; Peptidyl-Dipeptidase A; Proline; Protease Inhibitors | 1990 |
Pharmacological properties of the new non-sulfhydryl angiotensin converting enzyme inhibitor N-[8-amino-1(S)-carboxyoctyl]-L-alanyl-L-proline.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Captopril; Dipeptides; Enalapril; Enalaprilat; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Peptidyl-Dipeptidase A; Rabbits; Rats; Rats, Inbred WKY | 1990 |
The effects of bradykinin and the ischemic isolated rat heart.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Coronary Circulation; Coronary Disease; Coronary Vessels; Enalaprilat; Indomethacin; Myocardium; Rats; Vasodilation | 1990 |
Regional haemodynamic effects of captopril, enalaprilat and lisinopril in conscious water-replete and water-deprived Brattleboro rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Enalapril; Enalaprilat; Heart Rate; Hemodynamics; Lisinopril; Male; Rats; Rats, Brattleboro; Regional Blood Flow; Water Deprivation | 1990 |
Catabolism of substance P and neurotensin in the rat stomach wall is susceptible to inhibitors of angiotensin converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chromatography, High Pressure Liquid; Enalapril; Enalaprilat; Gastric Mucosa; Glycopeptides; Kinetics; Male; Neurotensin; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Thermolysin | 1986 |
Inhibition of dopamine beta-hydroxylase by captopril.
Topics: Adrenal Glands; Animals; Captopril; Cattle; Dopamine beta-Hydroxylase; Enalapril; Enalaprilat; Kinetics | 1989 |
Kinin antagonist reverses converting enzyme inhibitor-stimulated vascular prostaglandin I2 synthesis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Bradykinin; Captopril; Enalapril; Enalaprilat; Epoprostenol; In Vitro Techniques; Kidney Cortex; Kinins; Male; Prostaglandins; Rats; Rats, Inbred Strains | 1989 |
The increase in coronary flow induced by converting enzyme inhibitors is prostacyclin independent.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Coronary Circulation; Enalaprilat; Epoprostenol; In Vitro Techniques; Indomethacin; Male; Rats; Rats, Inbred Strains | 1989 |
The renin-angiotensin system during pregnancy in chronically instrumented, conscious rats.
Topics: Angiotensin I; Angiotensin II; Animals; Captopril; Drug Synergism; Enalaprilat; Female; Glomerular Filtration Rate; Hemodynamics; Norepinephrine; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; Renal Circulation; Renin; Renin-Angiotensin System; Vasoconstriction | 1989 |
Angiotensin converting enzyme inhibitors, captopril and enalaprilat, augment bradykinin-induced prostacyclin synthesis in cultured rat vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bradykinin; Captopril; Cells, Cultured; Drug Synergism; Enalaprilat; Kinetics; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains | 1989 |
The haemodynamic effects of two angiotensin converting enzyme inhibitors, enalaprilat and zofenoprilat, in the rat: evidence for the involvement of bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Dose-Response Relationship, Drug; Drug Interactions; Enalaprilat; Hemodynamics; Male; Rats; Rats, Inbred Strains; Receptors, Bradykinin; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Presynaptic angiotensin II receptors and captopril-induced adrenergic transmission failure probably not via converting enzyme inhibition in guinea-pig pulmonary arteries.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Enalapril; Enalaprilat; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Pulmonary Artery; Receptors, Angiotensin | 1987 |
Effects of teprotide, captopril and enalaprilat on arterial wall kininase and angiotensin converting activity.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Captopril; Enalapril; Enalaprilat; Male; Mesenteric Arteries; Rats; Rats, Inbred Strains; Teprotide | 1987 |
Electronic spectroscopy of cobalt angiotensin converting enzyme and its inhibitor complexes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cobalt; Enalapril; Enalaprilat; Enzyme Activation; Kinetics; Lung; Peptidyl-Dipeptidase A; Protein Binding; Rabbits; Spectrophotometry | 1987 |
Suppression of in vitro granulocytopoiesis by captopril and penicillamine.
Topics: Animals; Bone Marrow; Captopril; Catalase; Cells, Cultured; Colony-Forming Units Assay; Dogs; Enalapril; Enalaprilat; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leukopenia; Oxygen Consumption; Penicillamine; Sulfhydryl Compounds | 1988 |
Diagnosis of unilateral renovascular hypertension: comparative effect of intravenous enalaprilat and oral captopril.
Topics: Administration, Oral; Aldosterone; Blood Pressure; Captopril; Enalapril; Enalaprilat; False Negative Reactions; Humans; Hypertension, Renovascular; Infusions, Intravenous; Renin | 1988 |
Resistance to blockade by saralasin of effect of ACE inhibitors in conscious sodium-restricted dog.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Flow Velocity; Blood Pressure; Bradykinin; Captopril; Diet, Sodium-Restricted; Dogs; Enalapril; Enalaprilat; Female; Kidney; Male; Renal Circulation; Renin; Renin-Angiotensin System; Saralasin; Vascular Resistance | 1988 |
The effect of captopril or enalaprilic acid on the Na appetite of Na-deplete rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Appetite; Captopril; Drinking; Enalaprilat; Food Deprivation; Furosemide; Male; Rats; Rats, Inbred Strains; Sodium; Sodium, Dietary; Water Deprivation | 1988 |
Inhibition of rabbit lung angiotensin-converting enzyme by N alpha-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N alpha-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dialysis; Dipeptides; Edetic Acid; Enalaprilat; Hydrogen-Ion Concentration; Kinetics; Lisinopril; Lung; Mathematics; Rabbits; Zinc | 1985 |
Captopril inhibits sodium and water transport in the toad skin, a model of the distal nephron.
Topics: Animals; Biological Transport; Bufo arenarum; Captopril; Cell Membrane Permeability; Dipeptides; Enalaprilat; Female; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Distal; Male; Models, Biological; Nephrons; Nerve Tissue Proteins; Osmotic Pressure; Proline; Skin; Sodium; Teprotide; Water | 1985 |
Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Captopril; Enalapril; Enalaprilat; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Peptidyl-Dipeptidase A; Synaptic Membranes; Thiorphan; Tiopronin | 1985 |
Pharmacological comparison of captopril and MK-422 by a new method for measuring activity of angiotensin converting enzyme (ACE).
Topics: Animals; Antihypertensive Agents; Captopril; Enalapril; Enalaprilat; Enzyme Inhibitors; Hypertension, Renovascular; Peptidyl-Dipeptidase A; Radioimmunoassay; Renin-Angiotensin System; Swine; Swine, Miniature | 1985 |
Characterization of angiotensin converting enzyme by [3H]captopril binding.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Bromides; Captopril; Cobalt; Enalapril; Enalaprilat; Kinetics; Peptidyl-Dipeptidase A; Rats; Sodium Chloride; Thermodynamics; Tritium; Zinc | 1986 |
Centrally administered inhibitors of the generation and action of angiotensin II do not attenuate the increase in ACTH secretion produced by ether stress in rats.
Topics: Adrenocorticotropic Hormone; Angiotensin II; Animals; Captopril; Corticosterone; Corticotropin-Releasing Hormone; Enalapril; Enalaprilat; Male; Peptides; Rats; Renin; Renin-Angiotensin System; Saralasin; Stress, Physiological | 1986 |
Effects of acute angiotensin converting enzyme inhibition on renal blood flow in patients with stable congestive heart failure.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalapril; Enalaprilat; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Renal Circulation; Thermodilution | 1986 |
Bradykinin potentiating peptides isolated from alpha-casein tryptic hydrolysate.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Caseins; Chromatography, Gel; Drug Synergism; Enalapril; Enalaprilat; Guinea Pigs; Trypsin | 1987 |
Carboxyalkyl peptide inhibitors of kininase II: chiral synthesis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chromatography, Thin Layer; Enalapril; Enalaprilat; Indicators and Reagents; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Aggregate anaphylaxis and carboxypeptidase N.
Topics: 3-Mercaptopropionic Acid; Anaphylaxis; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carboxypeptidases; Enalapril; Enalaprilat; Guinea Pigs; Lung; Lysine Carboxypeptidase; Ovalbumin; Sulfhydryl Compounds | 1986 |
Antihypertensive action of angiotensin-I converting enzyme inhibitors in the kidney.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Enalapril; Enalaprilat; Female; Rabbits; Renal Circulation; Saralasin | 1987 |
Converting enzyme inhibition to identify and treat renin-mediated or sodium-volume related forms of increased peripheral resistance in hypertension and in congestive heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arterioles; Captopril; Enalapril; Enalaprilat; Heart Failure; Humans; Hypertension; Kinetics; Male; Nifedipine; Renin; Renin-Angiotensin System; Sodium; Teprotide; Vascular Resistance | 1983 |
Comparative effects of enalapril, enalaprilic acid and captopril in blocking angiotensin I-induced pressor and dipsogenic responses in spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dipeptides; Drug Evaluation, Preclinical; Enalapril; Enalaprilat; Hypertension; Male; Pressoreceptors; Proline; Rats; Rats, Inbred Strains; Renin-Angiotensin System; Thirst; Time Factors | 1984 |
Inhibition of angiotensin converting enzyme: mechanism and substrate dependence.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dipeptides; Enalaprilat; Hydrolysis; Kinetics; Mathematics; Peptides; Rabbits | 1984 |
Inhibition of angiotensin converting enzyme: dependence on chloride.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chlorides; Dipeptides; Enalaprilat; Kinetics; Mathematics; Rabbits; Sodium Chloride | 1984 |
Plasma enalapril levels and hormonal effects after short- and long-term administration in essential hypertension.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Dipeptides; Drug Interactions; Enalapril; Enalaprilat; Humans; Hypertension; Liver; Renin; Time Factors | 1984 |
Effects of angiotensin II and ACE inhibitors on electrically stimulated noradrenaline release from superfused rat brain slices.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Bridged Bicyclo Compounds; Captopril; Clonidine; Dipeptides; Enalaprilat; In Vitro Techniques; Norepinephrine; Ramipril; Rats | 1984 |
Effect of central administration of MK-422 (the diacid form of enalapril) on the development of hypertension in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electric Stimulation; Enalapril; Enalaprilat; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sympathetic Nervous System; Time Factors; Vascular Resistance | 1984 |
A comparison of the effects of two angiotensin converting enzyme inhibitors, SQ 14 225 and MK 422 in Na-restricted sheep.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Diet, Sodium-Restricted; Dipeptides; Enalaprilat; Female; Oligopeptides; Proline; Renin-Angiotensin System; Sheep; Teprotide | 1982 |
Carboxyl-terminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin-converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dipeptides; Drug Synergism; Enalaprilat; Hydrolysis; Kinetics; Lung; Male; Oligopeptides; Peptidyl-Dipeptidase A; Proline; Rats; Salivation; Substance P | 1984 |
Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.
Topics: Administration, Oral; Anesthesia; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Blood Pressure; Bradykinin; Captopril; Dipeptides; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Enalapril; Enalaprilat; Esterification; Female; Guinea Pigs; In Vitro Techniques; Male; Rats | 1981 |
Effect of captopril, MK-421 and MK-422 on fibrinolysis determined by 3 "in vitro" assays.
Topics: Animals; Captopril; Cattle; Dipeptides; Enalapril; Enalaprilat; Fibrin; Fibrinolysin; Fibrinolysis; Humans; In Vitro Techniques; Proline | 1984 |
Nitric oxide release from rat aortic smooth muscle cells is not attenuated by angiotensin converting enzyme inhibitors.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Captopril; Cells, Cultured; Cilazapril; Enalaprilat; Enzyme Induction; Humans; Interleukin-1; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Transcription, Genetic | 1994 |
The effect of angiotensin-converting enzyme inhibitors on human neutrophil chemotaxis in vitro.
Topics: Captopril; Cell Migration Inhibition; Chemotaxis, Leukocyte; Enalaprilat; Female; Humans; In Vitro Techniques; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tiopronin | 1994 |
Evidence for stimulation of neutrophil degranulation by selected angiotensin converting enzyme inhibitors in vitro.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cell Degranulation; Enalaprilat; Female; Humans; In Vitro Techniques; Lisinopril; Male; Middle Aged; Muramidase; Neutrophils; Peroxidase; Ramipril; Spectrophotometry; Zymosan | 1994 |
Angiotensin I is converted to angiotensin II by a serine protease in human detrusor smooth muscle.
Topics: Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth; Peptidyl-Dipeptidase A; Serine Endopeptidases; Urinary Bladder | 1994 |
The scavenging of oxygen free radicals by angiotensin converting enzyme inhibitors: the importance of the sulfhydryl group in the chemical structure of the compounds.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; In Vitro Techniques; Lisinopril; Reactive Oxygen Species; Sulfhydryl Compounds | 1994 |
Analysis of responses to bradykinin: effects of Hoe-140 in the hindquarters vascular bed of the cat.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Bradykinin; Captopril; Cats; Cyclooxygenase Inhibitors; Enalaprilat; Female; Glyburide; Hindlimb; Male | 1994 |
Design, synthesis and enzyme inhibitory activities of new trifluoromethyl-containing inhibitors for angiotensin converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Crystallography, X-Ray; Drug Design; Enalaprilat; Hydrocarbons, Fluorinated; Structure-Activity Relationship | 1994 |
N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs.
Topics: Acetylcysteine; Animals; Blood Pressure; Captopril; Drug Synergism; Enalaprilat; Hypertension; Male; Rats; Rats, Inbred SHR | 1994 |
Analysis of angiotensins I, II, and III in pulmonary vascular bed of the rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Blood Vessels; Captopril; Enalaprilat; Imidazoles; In Vitro Techniques; Losartan; Male; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Angiotensin converting enzyme inhibitors as oxygen free radical scavengers.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Catalase; Chlorides; Deoxyribose; Dimethyl Sulfoxide; Edetic Acid; Enalaprilat; Ferric Compounds; Free Radical Scavengers; Hydroxyl Radical; Hypoxanthine; Hypoxanthines; Lisinopril; Luminescent Measurements; Superoxide Dismutase; Xanthine Oxidase | 1993 |
Effect of captopril on vasoconstriction and Ca2+ fluxes in aortic smooth muscle.
Topics: Analysis of Variance; Angiotensin II; Animals; Aorta, Thoracic; Bradykinin; Calcium; Calcium Channels; Captopril; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enalaprilat; Hypertension; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasoconstriction | 1993 |
Sulfhydryl compounds, captopril, and MPG inhibit complement-mediated myocardial injury.
Topics: Animals; Captopril; Cardiomyopathies; Complement System Proteins; Coronary Circulation; Enalaprilat; Erythrocytes; Hemolysis; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Pressure; Rabbits; Sulfhydryl Compounds; Tiopronin | 1994 |
Captopril scavenges hydrogen peroxide and reduces, but does not eliminate, oxidant-induced cell injury.
Topics: Captopril; Cysteine; Enalaprilat; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Kidney Tubules; Oxidants; Oxidation-Reduction | 1993 |
Radionuclide scintirenography in the evaluation of patients with hypertension. American College of Cardiology position statement.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Humans; Hypertension, Renovascular; Male; Radioisotope Renography; Technetium Tc 99m Mertiatide; Technetium Tc 99m Pentetate | 1993 |
Endogenous angiotensin II modulates the effect of atrial natriuretic peptide on extracellular fluid partition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Pressure; Captopril; Enalaprilat; Extracellular Space; Hematocrit; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1993 |
Measurement of angiotensin I converting enzyme inhibition in the heart.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Captopril; Cricetinae; Dipeptides; Enalaprilat; Humans; Isoquinolines; Lisinopril; Male; Mesocricetus; Papillary Muscles; Tetrahydroisoquinolines | 1993 |
Effect of captopril, enalaprilat and mercaptopropionyl glycine (MPG) on the oxidative activity of human isolated neutrophils.
Topics: Acridines; Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Humans; Luminescent Measurements; Male; Middle Aged; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxidation-Reduction; Oxygen Consumption; Superoxides; Tiopronin | 1995 |
Angiotensin-converting enzyme inhibitor renography.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Humans; Hypertension, Renovascular; Radioisotope Renography | 1996 |
Angiotensin-converting enzyme inhibition preserves endothelium-dependent coronary microvascular responses during short-term ischemia-reperfusion.
Topics: Adenosine Diphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcimycin; Captopril; Coronary Vessels; Enalaprilat; Endothelium, Vascular; Female; Hemodynamics; Ionophores; Male; Microcirculation; Reperfusion Injury; Swine | 1996 |
[Angioedema following treatment with ACE inhibitors].
Topics: Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Gemfibrozil; Humans; Male; Middle Aged | 1996 |
Affinity of angiotensin I-converting enzyme (ACE) inhibitors for N- and C-binding sites of human ACE is different in heart, lung, arteries, and veins.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Binding Sites; Captopril; Cell Membrane; Coronary Vessels; Enalaprilat; Female; Humans; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Mammary Arteries; Myocardium; Peptidyl-Dipeptidase A; Pyridazines; Radioligand Assay; Rats; Saphenous Vein; Testis; Veins | 1996 |
Converting enzyme inhibitors cause pressure-independent resetting of baroreflex control of sympathetic outflow.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Blood Pressure; Captopril; Enalaprilat; Hypertension, Renal; Male; Phenylephrine; Rats; Rats, Inbred WKY; Reference Values; Sympathetic Nervous System; Time Factors | 1996 |
ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Coronary Vessels; Culture Techniques; Dogs; Enalaprilat; Kallikrein-Kinin System; Kininogens; Male; Microcirculation; Myocardium; Nitric Oxide; Nitrites; Oxygen Consumption; Ramipril | 1997 |
Serum angiotensin converting enzyme activity and response to angiotensin I in horses.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Enalapril; Enalaprilat; Female; Hemodynamics; Horses; Injections, Intravenous; Male; Peptidyl-Dipeptidase A; Renin-Angiotensin System | 1989 |
Effects of captopril and enalaprilat on intracellular Ca2+ content in isolated cardiomyocytes from rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Calcium Channels; Captopril; Cells, Cultured; Enalaprilat; Hypertension; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Cattle; Cells, Cultured; Chlorides; Chromatography, Gel; Enalaprilat; Glomerular Mesangium; Hydrogen-Ion Concentration; In Vitro Techniques; Isoenzymes; Molecular Weight; Oligopeptides; Peptidyl-Dipeptidase A; Rats; Substrate Specificity; Temperature | 1998 |
Inhibition of angiotensin-converting enzyme in human hand veins.
Topics: Administration, Oral; Adult; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Captopril; Dose-Response Relationship, Drug; Enalaprilat; Female; Hand; Humans; Male; Reference Values; Time Factors; Vasoconstriction; Vasodilation; Veins | 1999 |
Effects of captopril and enalaprilat on intracellular Ca2+, Na+ contents and pH in hypoxic and reoxygenated cardiomyocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Calcium Channel Blockers; Captopril; Cell Hypoxia; Enalaprilat; Hydrogen-Ion Concentration; Myocardium; Rats; Rats, Wistar; Sodium; Verapamil | 1997 |
Captopril inhibits peptidylglycine- alpha-hydroxylating monooxygenase: implications for therapeutic effects.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; CHO Cells; Copper; Cricetinae; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enalapril; Enalaprilat; Heart Atria; Kinetics; Male; Mixed Function Oxygenases; Multienzyme Complexes; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfhydryl Compounds | 1999 |
Angiotensin II concentrations and gut mucosal perfusion in infants undergoing cardiopulmonary bypass.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Enalaprilat; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Infant; Laser-Doppler Flowmetry; Prospective Studies; Regional Blood Flow | 1999 |
Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Enalaprilat; Humans; Kinetics; Lung; Macaca fascicularis; Peptidyl-Dipeptidase A; Ramipril; Rats; Rats, Sprague-Dawley; Swine | 1999 |
Timed inhibition of the renin-angiotensin system suppresses the rise in blood pressure upon awakening in spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Chronotherapy; Enalaprilat; Hypertension; Infusions, Intravenous; Losartan; Male; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 1999 |
Nitric oxide donors and angiotensin-converting enzyme inhibitors act in concert to inhibit human angiotensin-converting enzyme activity and platelet aggregation in vitro.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enalaprilat; Endothelium, Vascular; Female; Humans; Molsidomine; Nitric Oxide Donors; Penicillamine; Peptidyl-Dipeptidase A; Platelet Aggregation; S-Nitroso-N-Acetylpenicillamine; Umbilical Veins | 2000 |
Studies on the angiotensin-converting enzyme and the kinin B2 receptor in the rabbit jugular vein: modulation of contractile response to bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Enalaprilat; Jugular Veins; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Rabbits; Receptor, Bradykinin B2; Receptors, Bradykinin; Vasoconstriction | 2002 |
Captopril and quinapril reduce reactive oxygen species.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Enalaprilat; Fluoresceins; Fluorescent Dyes; Humans; Isoquinolines; Leukocytes, Mononuclear; Lisinopril; NADPH Oxidases; Quinapril; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines | 2002 |
Captopril and enalaprilat decrease antioxidant defences in human endothelial cells and are unable to protect against apoptosis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Apoptosis; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Enalaprilat; Endothelium, Vascular; Etoposide; Glutathione Peroxidase; Humans; Lipid Peroxidation; Malondialdehyde; Necrosis; Oxidative Stress; Superoxide Dismutase; Umbilical Veins | 2003 |
Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.
Topics: Animals; Antihypertensive Agents; Binding Sites; Captopril; Chlorides; CHO Cells; Cricetinae; Crystallography, X-Ray; Enalaprilat; Enzyme Inhibitors; Humans; Male; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Protein Structure, Tertiary; Testis | 2004 |
A calorimetric study of the binding of lisinopril, enalaprilat and captopril to angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calorimetry; Captopril; Enalaprilat; Lisinopril; Lung; Peptidyl-Dipeptidase A; Swine; Thermodynamics | 2004 |
The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Captopril; Enalaprilat; Female; Glucose; Humans; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Middle Aged; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Proteins c-akt; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrosine | 2006 |
The effect of sublingual captopril versus intravenous enalaprilat on angiotensin II plasma levels.
Topics: Adenocarcinoma; Administration, Sublingual; Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Humans; Injections, Intravenous; Intestinal Polyposis; Pancreatic Neoplasms; Parenteral Nutrition | 2006 |
Impairment of endothelium-dependent relaxation of rat aortas by homocysteine thiolactone and attenuation by captopril.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Captopril; Dose-Response Relationship, Drug; Enalaprilat; Endothelium, Vascular; Free Radicals; Homocysteine; Losartan; Malondialdehyde; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilation | 2007 |
Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells.
Topics: Animals; Captopril; Cells, Cultured; Enalaprilat; Fluorescent Antibody Technique; Kidney Medulla; Kidney Tubules, Collecting; Mice; Peptidyl-Dipeptidase A; Receptor, Bradykinin B2 | 2008 |
Protective effect of captopril and enalaprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced *OH generation and dopamine efflux in rat striatum.
Topics: 1-Methyl-4-phenylpyridinium; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Catechols; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enalaprilat; Hydroxybenzoates; Hydroxyl Radical; Iron; Male; Neostriatum; Phenols; Rats; Rats, Wistar | 2008 |
Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme.
Topics: Amyloid beta-Peptides; Angiotensins; Animals; Blotting, Western; Captopril; Catalytic Domain; Chlorocebus aethiops; COS Cells; Enalaprilat; Glycosylation; Humans; Mutation; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Reninoma: the importance of renal vein renin ratios for lateralisation and diagnosis.
Topics: Adolescent; Adult; Aldosterone; Antihypertensive Agents; Captopril; Enalaprilat; Female; Humans; Hypertension; Hypokalemia; Kidney Glomerulus; Kidney Neoplasms; Neoplasms; Nephrectomy; Renal Artery; Renal Veins; Renin; Tomography, X-Ray Computed; Ultrasonography, Doppler | 2014 |
The utility of renal venous renin studies in selection of patients with renal artery stenosis for angioplasty: a retrospective study.
Topics: Aged; Angioplasty; Angiotensin-Converting Enzyme Inhibitors; Captopril; Enalaprilat; Female; Humans; Kidney; Male; Middle Aged; Renal Artery Obstruction; Renin; Retrospective Studies | 2015 |