Page last updated: 2024-08-23

captopril and candesartan

captopril has been researched along with candesartan in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (14.55)	18.2507
2000's	34 (61.82)	29.6817
2010's	9 (16.36)	24.3611
2020's	4 (7.27)	2.80

Authors

Authors	Studies
Funakoshi, J; Kakumoto, M; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Gross, V; Lippoldt, A; Luft, FC; Schneider, W	1
Arakawa, K; Ideishi, M; Jimi, S; Kinoshita, A; Maeda, H; Miura, S; Sakai, T; Sasaguri, M	1
Higaki, J; Higashimori, K; Jiang, BB; Mikami, H; Ogihara, T; Rakugi, H; Shi, SJ	1
Ito, M; Iwao, T; Nakagawa, M; Saikawa, T; Sakata, T; Takakura, T; Yasunaga, S; Yonemochi, H	1
Akiyoshi, K; Ito, M; Iwao, T; Nakagawa, M; Saikawa, T; Teshima, Y; Yasunaga, S; Yonemochi, H	1
Baltatu, O; Buikema, H; Ganten, D; Nishimura, H; Urata, H	1
Atucha, NM; Cachofeiro, V; Fortepiani, LA; García-Estañ, J; Lahera, V; Ortíz, MC; Rodrigo, E; Ruilope, LM	1
Riegger, GA	1
Hata, A; Ikeda, Y; Kimura, H; Mochizuki, S; Nakamura, T; Obata, JE; Shido, K; Takano, H; Takeda, S; Yoshida, Y	1
Arakawa, K; Gondo, N; Ideishi, M; Kumagai, K; Nakashima, H; Urata, H	1
Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ	1
Erani, D; Fisher, ND; Hollenberg, NK; Laffel, LM; Lansang, MC; Osei, SY; Price, DA	1
Aiello, LP; Clermont, A; Feener, EP; Hata, Y; Pokras, F; Rook, SL; Suzuma, I; Suzuma, K	1
Ishibashi, T; Maruyama, Y; Nagata, K; Nakazato, K; Ohkawara, H; Sakamoto, T; Seino, Y; Teramoto, T; Yokoyama, K	1
Abe, I; Fujii, K; Goto, K; Kansui, Y	1
Fisher, ND; Hollenberg, NK; Lansang, MC; Osei, SY; Price, DA	1
Imamura, T; Ishikawa, T; Nakayama, K; Nejishima, H	1
Fujii, S; Kato, S; Kubota, I; Miyamoto, T; Miyashita, T; Takahashi, H; Takeishi, Y; Tomoike, H; Yoshimura, T	1
Bregonzio, C; Falcón-Neri, A; Ito, T; Saavedra, JM; Terrón, JA; Yamakawa, H	1
Fisher, ND; Gordon, MS; Hollenberg, NK; Laffel, LM; Lansang, MC; Perkins, B; Price, DA; Williams, GH	1
Jacobsen, P; Parving, HH; Pietraszek, L; Rossing, K	1
Buikema, H; de Zeeuw, D; Gschwend, S; Henning, RH; Pinto, YM; van Gilst, WH	1
Johnsson, C; Lindström, P; Ollerstam, A; Persson, AE; Wadström, J	1
Inomata, K; Tanaka, H	1
Bayram, I; Ozbek, H; Tuncer, I; Ugras, S	1
Hollenberg, NK; Laffel, LM; Lansang, MC; Price, DA; Stevanovic, R	1
Erhardt, LR	1
Cohen-Solal, A; Dietz, R; Eichhorn, E; Erhardt, L; Hobbs, FD; Krum, H; Maggioni, A; McKelvie, RS; McMurray, J; Piña, IL; Soler-Soler, J; Swedberg, K	1
Fisher, ND; Hollenberg, NK; Laffel, LM; Lansang, MC; Price, DA; Stevanovic, RD	1
Fukushima Kusano, K; Hisamatsu, K; Ishihara, K; Kajiya, M; Miura, A; Miura, D; Miura, R; Morita, H; Nagase, S; Nakamura, K; Ohe, T	1
Cai, H; Oak, JH	1
Cao, TB; Li, ZB; Liu, DY; Ma, LQ; Wang, LJ; Zhang, LL; Zhang, YP; Zhu, ZM	1
Fisher, ND; Forman, JP; Price, DA; Stevanovic, R	1
Briggs, JP; Chen, L; Faulhaber-Walter, R; Huang, Y; Kim, SM; Mizel, D; Oppermann, M; Schnermann, J	1
Huang, Z; Jansson, L; Sjöholm, A	1
Kageyama, S	1
Hirafuji, M; Iizuka, K; Kawaguchi, H; Machida, T	1
Imai, K; Tsunoda, M; Yamagishi, M; Yanagisawa, T	1
de Zeeuw, D; Lambers-Heerspink, H	1
Gemici, B; Izgüt-Uysal, VN; Ongüt, G; Tan, R	1
Fukuda, K; Hirooka, K; Itano, T; Mizote, M; Nakamura, T; Shiraga, F	1
Briggs, JP; Chen, L; Chen, M; Eisner, C; Gomez, RA; Huang, Y; Kim, SM; Li, L; Mizel, D; Oppermann, M; Schnermann, J; Sequeira Lopez, ML; Weinstein, LS	1
Hounoki, H; Ogawa, R; Shinoda, K; Sugiyama, E; Taki, H; Tobe, K	1
Clifford, PS; Davis, MJ; Hill, MA; Hong, K; Hong, Z; Meininger, GA; Sun, Z; Yang, Y; Zhao, G	1
Bishop, NM; Cipolla, MJ; Li, Z; Lindner, DP	1
Franco, R; Garrido-Gil, P; Labandeira, CM; Labandeira-Garcia, JL; Navarro, G; Pedrosa, MA; Rodriguez-Perez, AI; Valenzuela, R	1
Baka, T; Simko, F	1

Reviews

4 review(s) available for captopril and candesartan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[ACE inhibitors or AT1 receptor antagonists?]. Deutsche medizinische Wochenschrift (1946), 1999, Sep-24, Volume: 124 Suppl 2 Topics: Age Factors; Aged; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Clinical Trials as Topic; Death, Sudden, Cardiac; Enalapril; Heart Failure; Humans; Losartan; Prodrugs; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Time Factors	1999
A review of the current evidence for the use of angiotensin-receptor blockers in chronic heart failure. International journal of clinical practice, 2005, Volume: 59, Issue:5 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Drug Therapy, Combination; Drug Tolerance; Heart Failure; Humans; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan	2005
[Clinical trials of ACE inhibitors and ARB for treatment of patients with hypertension, heart failure, and diabetic nephropathy in Japan--special reference to the dosage schedule and adverse effects]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Cough; Diabetic Nephropathies; Heart Failure; Humans; Hypertension; Japan; Losartan; Randomized Controlled Trials as Topic; Tetrazoles	2008

Trials

3 trial(s) available for captopril and candesartan

Article	Year
Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus. Kidney international, 2003, Volume: 63, Issue:1 Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Kidney Glomerulus; Male; Middle Aged; Renal Circulation; Renin-Angiotensin System; Tetrazoles	2003
Renoprotective effects of adding angiotensin II receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trial. Diabetes care, 2003, Volume: 26, Issue:8 Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Kidney; Lisinopril; Male; Middle Aged; Tetrazoles; Treatment Outcome	2003
Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitus. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2005, Volume: 6, Issue:2 Topics: Adult; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Diabetes Mellitus, Type 1; Female; Hemodynamics; Humans; Kidney Function Tests; Male; Middle Aged; p-Aminohippuric Acid; Renal Circulation; Renin; Renin-Angiotensin System; Tetrazoles; Water-Electrolyte Balance	2005

Other Studies

48 other study(ies) available for captopril and candesartan

Article	Year
Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences, 2002, Feb-15, Volume: 70, Issue:13 Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Drug Interactions; Humans; Time Factors	2002
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Effect of captopril and angiotensin II receptor blockade on pressure natriuresis in transgenic TGR(mRen-2)27 rats. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Benzimidazoles; Biphenyl Compounds; Captopril; Glomerular Filtration Rate; Kidney; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Tetrazoles	1995
Comparative effects of an angiotensin-converting enzyme inhibitor and an angiotensin II antagonist in Dahl rats. Blood pressure. Supplement, 1994, Volume: 5 Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Drinking; Eating; Heart Rate; Hypertension; Male; Norepinephrine; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Sodium Chloride; Tetrazoles	1994
Augmentation by converting enzyme inhibition of accelerated endothelin release from rat mesenteric arteries following nephrectomy. Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1 Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Endothelins; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nephrectomy; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles	1994
Angiotensin-converting enzyme inhibitor up-regulates cardiac beta-receptors in cultured neonatal rat myocytes. Japanese circulation journal, 1997, Volume: 61, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Captopril; Cells, Cultured; Myocardial Contraction; Myocardium; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Tetrazoles; Up-Regulation	1997
Mechanism of beta-adrenergic receptor upregulation induced by ACE inhibition in cultured neonatal rat cardiac myocytes: roles of bradykinin and protein kinase C. Circulation, 1998, Jun-09, Volume: 97, Issue:22 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Bradykinin; Captopril; Cells, Cultured; Female; In Vitro Techniques; Isoproterenol; Male; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Bradykinin; Tetrazoles; Up-Regulation	1998
Functional evidence for alternative ANG II-forming pathways in hamster cardiovascular system. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Aprotinin; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Chymases; Cricetinae; Heart Ventricles; Humans; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Oligopeptides; Serine Endopeptidases; Substrate Specificity; Tetrazoles; Vasoconstriction	1998
Pressure natriuresis in nitric oxide-deficient hypertensive rats: effect of antihypertensive treatments. Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Captopril; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Verapamil	1999
Angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. The Journal of laboratory and clinical medicine, 2000, Volume: 135, Issue:4 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Collagen; Fibrosis; Heart; Heart Ventricles; Hemodynamics; Hydralazine; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; Myosin Heavy Chains; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Tetrazoles	2000
Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation. Circulation, 2000, Jun-06, Volume: 101, Issue:22 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Fibrillation; Atrial Function; Benzimidazoles; Biphenyl Compounds; Captopril; Dogs; Female; Heart Conduction System; Male; Myocardium; Pacemaker, Artificial; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sinoatrial Node; Tetrazoles; Time Factors	2000
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles	2001
Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus. Kidney international, 2001, Volume: 59, Issue:4 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Vessels; Captopril; Diabetes Mellitus, Type 1; Female; Humans; Male; Renal Circulation; Tetrazoles	2001
Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes, 2001, Volume: 50, Issue:2 Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Cattle; Cells, Cultured; Diabetic Angiopathies; Diabetic Retinopathy; Endothelium, Vascular; Hypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinal Vessels; RNA, Messenger; Stress, Mechanical; Tetrazoles	2001
Effects of blockade of the renin-angiotensin system on tissue factor and plasminogen activator inhibitor-1 synthesis in human cultured monocytes. Journal of hypertension, 2001, Volume: 19, Issue:4 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Cells, Cultured; Culture Media; Humans; Monocytes; Peptidyl-Dipeptidase A; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Thromboplastin; Tumor Necrosis Factor-alpha	2001
Bradykinin enhances sympathetic neurotransmission in rat blood vessels. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:1 Topics: Adenosine Triphosphate; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Bradykinin; Captopril; Cyclooxygenase Inhibitors; Drug Interactions; Excitatory Postsynaptic Potentials; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Neuromuscular Junction; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Stimulation, Chemical; Sympathetic Nervous System; Synaptic Transmission; Tetrazoles	2002
Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2001, Volume: 2, Issue:1 Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Diet, Sodium-Restricted; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Renal Circulation; Tetrazoles	2001
Non-contribution of renin-angiotensin system to pressor response to N(G)-nitro-L-arginine in dogs. Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:1 Topics: Animals; Antihypertensive Agents; Arginine; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bradycardia; Bradykinin; Captopril; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Heart Rate; Injections, Intravenous; Male; Nitroarginine; Renin; Renin-Angiotensin System; Stereoisomerism; Tetrazoles	2002
Comparison of nitric oxide production in response to carbachol between macrovascular and microvascular cardiac endothelial cells. Circulation journal : official journal of the Japanese Circulation Society, 2002, Volume: 66, Issue:5 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Carbachol; Cells, Cultured; Coronary Circulation; Endothelium, Vascular; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Muscarinic M3; Receptors, Angiotensin; Receptors, Muscarinic; Tetrazoles; Type C Phospholipases	2002
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. Stroke, 2002, Volume: 33, Issue:9 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Brain; Brain Ischemia; Calcium Channel Blockers; Captopril; Cerebrovascular Circulation; Disease Models, Animal; Drug Administration Schedule; Hypertension; Infarction, Middle Cerebral Artery; Male; Nicardipine; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Tetrazoles	2002
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade. British journal of pharmacology, 2003, Volume: 139, Issue:7 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Captopril; Chronic Disease; Coronary Vessels; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart; Heart Failure; Hydrazines; Imidazoles; Indomethacin; Lisinopril; Losartan; Male; Mesenteric Arteries; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tetrazoles; Tetrodotoxin; Vascular Resistance	2003
Effects of increased intra-abdominal pressure and volume expansion on renal function in the rat. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:11 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Disease Models, Animal; Kidney; Male; Pneumoperitoneum, Artificial; Pressure; Rats; Rats, Inbred Strains; Renin-Angiotensin System; Tetrazoles	2003
Protective effect of benidipine against sodium azide-induced cell death in cultured neonatal rat cardiac myocytes. Journal of pharmacological sciences, 2003, Volume: 93, Issue:2 Topics: Adenosine Triphosphate; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Captopril; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dihydropyridines; Dipeptides; Dose-Response Relationship, Drug; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria, Muscle; Myocytes, Cardiac; Nifedipine; Rats; Rats, Sprague-Dawley; Sodium Azide; Tetrazoles	2003
Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2003, Volume: 55, Issue:2-3 Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Carbon Tetrachloride; Cell Count; Disease Models, Animal; Immunohistochemistry; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Treatment Outcome	2003
These drugs are an ACE in the hole. Angiotensin receptor blockers prove okay when an ACE inhibitor causes problems. Harvard heart letter : from Harvard Medical School, 2004, Volume: 14, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Cardiac Output, Low; Cough; Humans; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan	2004
ACE and non-ACE pathways in the renal vascular response to RAS interruption in type 1 diabetes mellitus. Kidney international, 2005, Volume: 67, Issue:3 Topics: Adult; Benzimidazoles; Biphenyl Compounds; Captopril; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Humans; Male; Peptidyl-Dipeptidase A; Renal Circulation; Renin-Angiotensin System; Tetrazoles	2005
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice. European journal of heart failure, 2005, Volume: 7, Issue:5 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Benzopyrans; Biphenyl Compounds; Bisoprolol; Captopril; Carbazoles; Carvedilol; Drug Therapy, Combination; Enalapril; Ethanolamines; Evidence-Based Medicine; Guideline Adherence; Heart Failure; Humans; Indoles; Lisinopril; Metoprolol; Mineralocorticoid Receptor Antagonists; Nebivolol; Practice Guidelines as Topic; Propanolamines; Ramipril; Spironolactone; Stroke Volume; Tetrazoles; Valine; Valsartan	2005
Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells. Journal of pharmacological sciences, 2006, Volume: 101, Issue:3 Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Male; Mineralocorticoid Receptor Antagonists; Spironolactone; Tetrazoles; Tumor Necrosis Factor-alpha	2006
Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes, 2007, Volume: 56, Issue:1 Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Diabetes Mellitus, Experimental; Hydrogen Peroxide; Hyperglycemia; Mice; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction; Superoxides; Tetrazoles; Vasodilation	2007
[Renin-angiotensin system in mesenteric adipose tissues in rats with metabolic syndrome]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2006, Volume: 28, Issue:6 Topics: Adipocytes; Adipose Tissue; Angiotensin II; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Calcium; Captopril; Cells, Cultured; Male; Metabolic Syndrome; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles	2006
Racial differences in renal vascular response to angiotensin blockade with captopril or candesartan. Journal of hypertension, 2007, Volume: 25, Issue:4 Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Black or African American; Blood Pressure; Captopril; Diet, Sodium-Restricted; Female; Humans; Kidney; Linear Models; Male; Middle Aged; Natriuresis; Reference Values; Renal Circulation; Renal Plasma Flow; Tetrazoles; White People	2007
Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Furosemide; Mice; Mice, Knockout; Osmolar Concentration; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Renin; RNA, Messenger; Sodium Chloride, Dietary; Tetrahydroisoquinolines; Tetrazoles	2007
Gender-specific regulation of pancreatic islet blood flow, insulin levels and glycaemia in spontaneously diabetic Goto-Kakizaki rats. Clinical science (London, England : 1979), 2008, Volume: 115, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Captopril; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Irbesartan; Islets of Langerhans; Male; Pravastatin; Rats; Rats, Mutant Strains; Regional Blood Flow; Sex Factors; Tetrazoles	2008
Pulsatile mechanical pressure promotes Angiotensin-converting enzyme expression in aortic smooth muscle cells. Cardiovascular drugs and therapy, 2008, Volume: 22, Issue:5 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Aorta; Atmospheric Pressure; Benzimidazoles; Biphenyl Compounds; Captopril; Cell Line; Cell Proliferation; Colorimetry; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Tetrazoles; Time Factors	2008
Study of the acute cardiovascular effects of several antihypertensive agents with the measurement of plasma catecholamines in mice. Analytical and bioanalytical chemistry, 2009, Volume: 394, Issue:4 Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Catecholamines; Chromatography, High Pressure Liquid; Heart Rate; Imidazoles; Luminescence; Male; Mice; Mice, Inbred C57BL; Nicardipine; Nitroprusside; Oxalates; Reproducibility of Results; Sensitivity and Specificity; Tetrazoles; Time Factors	2009
Drug dosing for renoprotection: maybe it's time for a drug efficacy-safety score? Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Humans; Hypertension; Kidney Diseases; Proteinuria; Tetrazoles	2009
Expressions of inducible nitric oxide synthase and cyclooxygenase-2 in gastric ischemia-reperfusion: role of angiotensin II. The Journal of surgical research, 2010, Jun-01, Volume: 161, Issue:1 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Cyclooxygenase 2; Dinoprostone; Gastritis; Imidazoles; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; Tetrazoles	2010
Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor. Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:7 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin B2 Receptor Antagonists; Captopril; Cell Survival; Electroretinography; Enzyme-Linked Immunosorbent Assay; Female; Imidazoles; Immunoenzyme Techniques; Neuroprotective Agents; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells; Tetrazoles	2010
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent. Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6 Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enalapril; Female; GTP-Binding Protein alpha Subunits, Gs; Juxtaglomerular Apparatus; Male; Mice; Mice, Knockout; Models, Animal; Nitric Oxide; Prostaglandins; Renin; Signal Transduction; Tetrahydroisoquinolines; Tetrazoles	2010
Reversible posterior leukoencephalopathy syndrome in a patient with systemic sclerosis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2011, Volume: 17, Issue:5 Topics: Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Scleroderma, Systemic; Tetrazoles; Tomography, X-Ray Computed; Treatment Outcome	2011
Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles. The Journal of physiology, 2016, 12-01, Volume: 594, Issue:23 Topics: Abdominal Muscles; Actins; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterioles; Benzimidazoles; Biphenyl Compounds; Captopril; Cells, Cultured; Diglycerides; Imidazoles; Indoles; Losartan; Male; Maleimides; Muscle Development; Muscle Fibers, Skeletal; Pressure; Protein Kinase C; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents	2016
ACE (Angiotensin-Converting Enzyme) Inhibition Reverses Vasoconstriction and Impaired Dilation of Pial Collaterals in Chronic Hypertension. Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Captopril; Chronic Disease; Collateral Circulation; Hydralazine; Hypertension; Male; Pia Mater; Random Allocation; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Tetrazoles; Vasoconstriction; Vasodilator Agents; Vasomotor System	2020
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical science (London, England : 1979), 2021, 02-12, Volume: 135, Issue:3 Topics: ADAM17 Protein; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; COVID-19; COVID-19 Drug Treatment; Female; Humans; Lung; Male; Rats; Renin-Angiotensin System; SARS-CoV-2; Tetrazoles	2021
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat? Clinical science (London, England : 1979), 2021, 04-30, Volume: 135, Issue:8 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; COVID-19; Humans; Pandemics; Peptidyl-Dipeptidase A; Rats; Renin-Angiotensin System; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Tetrazoles	2021