captax and morpholine

captax has been researched along with morpholine* in 2 studies

Other Studies

2 other study(ies) available for captax and morpholine

Article	Year
Comparative studies of the sensitization potential of morpholine, 2-mercaptobenzothiazole and 2 of their derivatives in guinea pigs. Contact dermatitis, 1988, Volume: 19, Issue:1 The aim of this study was to determine the sensitization potential of morpholine (M), 4,4'-dithiodimorpholine (DTDM), morpholinyl-mercaptobenzothiazole (MMBT) and 2-mercaptobenzothiazole (MBT) in guinea pigs. 5% and 10% DTDM, MMBT and MBT produced irritation reactions. M up to 10% failed to irritate. Sensitization tests showed that all the guinea pigs treated with DTDM and MMBT were sensitized. Cross-sensitization tests showed that 60% of the DTDM-sensitized animals reacted to challenge with MMBT; 30% of the animals sensitized to DTDM reacted to challenge with M; 80% of the MMBT-sensitized animals reacted to challenge with MBT and 10% to challenge with M; 42% of the MBT-sensitized animals reacted to MMBT. The rank order of sensitization potential in guinea pigs observed from this study is DTDM, MMBT and then MBT. It appears that the disulfide bond, sulfur linkage and the sulfhydryl group may each play a role in the sensitizing capacity of these compounds. Topics: Allergens; Animals; Benzothiazoles; Cross Reactions; Guinea Pigs; Irritants; Male; Morpholines; Patch Tests; Structure-Activity Relationship; Thiazoles	1988
Studies of the reactivity of morpholine, 2-mercaptobenzothiazole and 2 of their derivatives with selected amino acids. Contact dermatitis, 1988, Volume: 19, Issue:1 Previous studies in guinea pigs showed that DTDM, MMBT and MBT were sensitizing agents. The purpose of this study was to investigate the biochemical basis of this sensitization reaction. The reactions of representative amino acids, Cys, Lys & Gly, with morpholine, DTDM, MMBT & MBT were examined. New compounds were found between MMBT and all 3 amino acids. Additional new compounds were seen for Cys/MBT, Cys/DTDM, Lys/MBT & Gly/DTDM. No reaction was observed with morpholine. The new compounds were examined spectroscopically. Results suggest that the sensitizing nature of DTDM is probably a reaction of its disulfide bond with the -SH & -NH2 groups of amino acid moieties. The conjugation of Cys/MMBT may be via the same reaction mechanism. The -SH group of MBT may react either via oxidation and/or thioester formation with the carboxylate group of amino acids. These results also suggest that in vitro tests may predict the sensitizing potential of certain compounds. Topics: Amino Acids; Benzothiazoles; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Thin Layer; Morpholines; Spectrum Analysis; Thiazoles	1988

Article

Year

Comparative studies of the sensitization potential of morpholine, 2-mercaptobenzothiazole and 2 of their derivatives in guinea pigs.

Contact dermatitis, 1988, Volume: 19, Issue:1

The aim of this study was to determine the sensitization potential of morpholine (M), 4,4'-dithiodimorpholine (DTDM), morpholinyl-mercaptobenzothiazole (MMBT) and 2-mercaptobenzothiazole (MBT) in guinea pigs. 5% and 10% DTDM, MMBT and MBT produced irritation reactions. M up to 10% failed to irritate. Sensitization tests showed that all the guinea pigs treated with DTDM and MMBT were sensitized. Cross-sensitization tests showed that 60% of the DTDM-sensitized animals reacted to challenge with MMBT; 30% of the animals sensitized to DTDM reacted to challenge with M; 80% of the MMBT-sensitized animals reacted to challenge with MBT and 10% to challenge with M; 42% of the MBT-sensitized animals reacted to MMBT. The rank order of sensitization potential in guinea pigs observed from this study is DTDM, MMBT and then MBT. It appears that the disulfide bond, sulfur linkage and the sulfhydryl group may each play a role in the sensitizing capacity of these compounds.

Topics: Allergens; Animals; Benzothiazoles; Cross Reactions; Guinea Pigs; Irritants; Male; Morpholines; Patch Tests; Structure-Activity Relationship; Thiazoles

1988

Studies of the reactivity of morpholine, 2-mercaptobenzothiazole and 2 of their derivatives with selected amino acids.

Contact dermatitis, 1988, Volume: 19, Issue:1

Previous studies in guinea pigs showed that DTDM, MMBT and MBT were sensitizing agents. The purpose of this study was to investigate the biochemical basis of this sensitization reaction. The reactions of representative amino acids, Cys, Lys & Gly, with morpholine, DTDM, MMBT & MBT were examined. New compounds were found between MMBT and all 3 amino acids. Additional new compounds were seen for Cys/MBT, Cys/DTDM, Lys/MBT & Gly/DTDM. No reaction was observed with morpholine. The new compounds were examined spectroscopically. Results suggest that the sensitizing nature of DTDM is probably a reaction of its disulfide bond with the -SH & -NH2 groups of amino acid moieties. The conjugation of Cys/MMBT may be via the same reaction mechanism. The -SH group of MBT may react either via oxidation and/or thioester formation with the carboxylate group of amino acids. These results also suggest that in vitro tests may predict the sensitizing potential of certain compounds.

Topics: Amino Acids; Benzothiazoles; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Thin Layer; Morpholines; Spectrum Analysis; Thiazoles

1988