capsaicin has been researched along with urea in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (38.46) | 29.6817 |
| 2010's | 22 (56.41) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Buchheit, KH; Campbell, EA; Chaudhry, N; James, IF; Kane, S; Panesar, M; Patel, S; Sandells, B; Urban, L | 1 |
| Jaggar, SI; James, IF; Rice, AS; Scott, HC | 1 |
| Apodaca, G; Birder, L; Kiss, S; Meyers, S; Ruiz, W; Zeidel, M | 1 |
| El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ | 1 |
| Faltynek, CR; Han, P; Jarvis, MF; Neelands, TR; Surowy, CS | 1 |
| Davis, JB; Fell, S; Gunthorpe, MJ; Jerman, JC; Rami, HK; Randall, AD; Sanderson, D; Sargent, B; Smart, D; Stemp, G; Stevens, AJ; Thompson, M | 1 |
| Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C | 1 |
| Dömötör, A; Hunyady, B; Kereskay, L; Mózsik, G; Szekeres, G; Szolcsányi, J | 1 |
| Arpino, S; Brough, S; Davis, JB; Egerton, J; Gunthorpe, MJ; Hannan, SL; Holland, VA; Jerman, JC; Lappin, SC; Rami, HK; Randall, A; Smart, D; Smith, GD; Thompson, M; Winborn, K; Wright, J | 1 |
| Aono, H; Murai, M; Nose, M; Oki, K; Sasano, M; Seki, I; Setoguchi, C; Suhara, H; Tsuji, F | 1 |
| Conway, SJ | 1 |
| Bradbury, M; Gogas, K; Jaffe, R; McMackin, M; Mills, C; Slee, D; Yu, J; Zininberg, E | 1 |
| Faltynek, CR; Han, P; Kort, M; McDonald, HA; Moreland, RB; Neelands, TR; Puttfarcken, PS; Vos, MH | 1 |
| Aerssens, J; Boeckxstaens, GE; Bulmer, DC; de Hoogt, R; de Jonge, WJ; Klooker, TK; Lee, K; Peeters, PJ; Stanisor, OI; van den Wijngaard, RM; van der Coelen, D; Welting, O; Wouters, MM | 1 |
| Durrant-Finn, U; Mügge, C; Nenoff, P; Osten, B | 1 |
| Bautista, DM; Lennertz, RC; Stucky, CL; Tsunozaki, M | 1 |
| Beattie, RE; Knopp, K; Liu, B; Sher, E; Ursu, D | 1 |
| Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ | 1 |
| Alenmyr, L; Andersson, M; Greiff, L; Högestätt, ED; Sterner, O; Zygmunt, PM | 1 |
| Biggadike, K; Busza, A; Campbell, S; Changani, K; Coe, D; Denyer, J; Dinnewell, L; Hotee, S; Lines, M; Pindoria, K; Saklatvala, P; Thompson, SA; Vitulli, G | 1 |
| Beerahee, M; Denyer, J; Fokkens, W; Holland, C; Newlands, A; Segboer, C; Smart, K; Terreehorst, I; Tsitoura, DC; van Drunen, C | 1 |
| Dockry, R; Holt, K; Kelsall, A; Khalid, S; Murdoch, R; Newlands, A; Smart, K; Smith, JA; Woodcock, A | 1 |
| Ishii, K; Ito, H; Kuroki, T; Mizuta, A; Mori, A; Nakahara, T; Okuno, Y; Sagawa, T; Sakamoto, K; Sekiya, H; Watanabe, A | 1 |
| Fernando, D; Gibson, RA; McCallum, S; Mistry, H; Robertson, J; Wyres, M; Yosipovitch, G | 1 |
| Abbasnejad, M; Amirkhosravi, L; Esmaeili-Mahani, S; Kooshki, R; Rafie, F; Raoof, M; Raoof, R; Sheibani, V | 1 |
| Adamek, L; Adaszek, L; Balicki, I; Brodzki, A; Golynski, M; Lutnicki, K; Smiech, A; Szczepanik, M; Wilkolek, P | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Raoof, M | 2 |
| Abbasnejad, M; Bahaaddini, M; Esmaeili-Mahani, S; Khatamsaz, S; Raoof, M | 1 |
| Metz, M; Staubach, P | 1 |
| Bae, IH; Burns, A; Choi, G; Choi, JK; Fagg, R; Gatfield, KM; Lee, CS; Naidoo, AA; Park, M; Park, YH; Powell, AJ; Vidgeon-Hart, M | 1 |
| Liu, L; Sun, T; Wang, L; Zhang, L | 1 |
| Bartusik-Aebisher, D; Florek-Łuszczki, M; Kołodziejczyk, P; Tutka, P; Wlaź, A; Łuszczki, JJ | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Raoof, M; Shahsavari, F | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Mansoori, M; Raoof, M; Soofiabadi, S | 1 |
| Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ | 1 |
| Gao, M; Hu, J; Qian, H; Qiao, Z; Wang, Q; Wang, Y; Yan, L; Zhang, W; Zhang, Y | 1 |
| Barniol-Xicota, M; Brea, J; Calvó-Tusell, C; Cobos, EJ; Codony, S; Corpas, R; Entrena, JM; Feixas, F; González-Cano, R; Griñán-Ferré, C; Hammock, BD; Jora, B; Loza, MI; Martínez, AL; Morisseau, C; Osuna, S; Pallàs, M; Pérez, B; Pérez, C; Rodríguez-Franco, MI; Sanfeliu, C; Vázquez, S; Verhelst, SHL | 1 |
3 review(s) available for capsaicin and urea
| Article | Year |
|---|---|
TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.
Topics: Animals; Benzimidazoles; Capsaicin; Humans; Ligands; Pyrrolidines; Sodium Channel Blockers; TRPV Cation Channels; Urea | 2008 |
[Pruritus and dryness of the skin in chronic kidney insufficiency and dialysis patients - a review].
Topics: Antipruritics; Arginine; Calcineurin Inhibitors; Capsaicin; Controlled Clinical Trials as Topic; Humans; Ichthyosis; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Ointments; Prospective Studies; Pruritus; Renal Dialysis; Skin; Tacrolimus; Urea; Uremia | 2009 |
Itch Management: Topical Agents.
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Antipruritics; Camphor; Cannabinoid Receptor Agonists; Capsaicin; Chronic Disease; Dermatologic Agents; Glycerol; Humans; Menthol; Narcotic Antagonists; Pruritus; Skin Care; Sodium Chloride; Urea | 2016 |
4 trial(s) available for capsaicin and urea
| Article | Year |
|---|---|
Effect of mucosal TRPV1 inhibition in allergic rhinitis.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Fluorometry; HEK293 Cells; Humans; Male; Pyrrolidines; Rhinitis, Allergic, Seasonal; TRPV Cation Channels; Urea; Young Adult | 2012 |
Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.
Topics: Adolescent; Adult; Capsaicin; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrrolidines; Rhinitis; TRPV Cation Channels; Urea; Visual Analog Scale | 2014 |
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial.
Topics: Administration, Inhalation; Adult; Aged; Animals; Antitussive Agents; Capsaicin; Chronic Disease; Cough; Cross-Over Studies; Double-Blind Method; Female; Gene Expression; Humans; Male; Middle Aged; Pyrrolidines; Quality of Life; Severity of Illness Index; Treatment Outcome; TRPV Cation Channels; Urea | 2014 |
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.
Topics: Administration, Topical; Adult; Capsaicin; Healthy Volunteers; Histamine; Humans; Male; Middle Aged; Pruritus; Pyrrolidines; Skin; TRPV Cation Channels; Urea | 2014 |
32 other study(ies) available for capsaicin and urea
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Eye; Female; Ganglia, Spinal; Guinea Pigs; Hindlimb; Hyperalgesia; Irritants; Male; Mice; Mice, Inbred Strains; Nociceptors; Nose; Odorants; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Turpentine; Urea | 2000 |
The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder.
Topics: Algorithms; Analgesics; Animals; Capsaicin; Cystitis; Dose-Response Relationship, Drug; Hyperalgesia; Male; Rats; Rats, Wistar; Reflex; Time Factors; Turpentine; Urea; Urination | 2001 |
Disruption of bladder epithelium barrier function after spinal cord injury.
Topics: Animals; Capsaicin; Electric Impedance; Epithelium; Female; Ganglionic Blockers; Hexamethonium; Microscopy, Electron; Microscopy, Electron, Scanning; Permeability; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord Injuries; Time Factors; Urea; Urinary Bladder; Water | 2003 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relationship, Drug; Edema; Formaldehyde; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Isoquinolines; Ligation; Male; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain, Postoperative; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Nerves; Urea | 2005 |
Acidification of rat TRPV1 alters the kinetics of capsaicin responses.
Topics: Acids; Animals; Capsaicin; Cell Line; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Isoquinolines; Kinetics; Protons; Rats; Time Factors; TRPV Cation Channels; Urea | 2005 |
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Topics: Administration, Oral; Animals; Capsaicin; Cell Line; Drug Design; Guinea Pigs; Humans; Molecular Structure; Pyrrolidines; Rats; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2006 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea | 2006 |
Participation of capsaicin-sensitive afferent nerves in the gastric mucosa of patients with Helicobacter pylori-positive or-negative chronic gastritis.
Topics: Adult; Afferent Pathways; Aged; Breath Tests; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Dyspepsia; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Male; Middle Aged; Substance P; TRPV Cation Channels; Urea; Urease | 2007 |
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Topics: Acids; Animals; Binding, Competitive; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hot Temperature; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Molecular Structure; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Transfection; TRPV Cation Channels; Urea | 2007 |
SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pyridines; Rats; Rats, Inbred Lew; Somatostatin; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Urea | 2008 |
Effects of the transient receptor potential vanilloid 1 antagonist A-425619 on body temperature and thermoregulation in the rat.
Topics: Administration, Oral; Animals; Body Temperature; Body Temperature Regulation; Capsaicin; Circadian Rhythm; Drug Administration Schedule; Fever; Hypothalamus; Hypothermia; Isoquinolines; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Time Factors; TRPV Cation Channels; Urea | 2008 |
Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
Topics: Aminobutyrates; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Isoquinolines; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tissue Culture Techniques; Trigeminal Ganglion; TRPV Cation Channels; Urea | 2008 |
Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats.
Topics: Animals; Blotting, Western; Capsaicin; Catheterization; Colon; Drinking Behavior; Female; Immunohistochemistry; Macrophages; Mast Cells; Maternal Deprivation; Nerve Growth Factor; Pregnancy; Pyrrolidines; Rats; Rats, Long-Evans; Stress, Psychological; T-Lymphocytes; Transcription, Genetic; TRPV Cation Channels; Urea | 2009 |
Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
Topics: Action Potentials; Amides; Animals; Animals, Newborn; Capsaicin; Cells, Cultured; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mustard Plant; Nerve Fibers; Nerve Growth Factors; Neural Conduction; Neurons, Afferent; Paresthesia; Plant Oils; Sensory Receptor Cells; Sensory System Agents; Skin; Statistics, Nonparametric; Touch; Trigeminal Ganglion; Urea | 2010 |
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.
Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Lipid Metabolism; Male; Neurons, Afferent; Pain; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sensory Receptor Cells; Solubility; TRPV Cation Channels; Urea | 2010 |
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans; Hyperalgesia; Hypoxia; Isoquinolines; Male; Mice; Mice, Inbred Strains; Microelectrodes; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; TRPV Cation Channels; Urea | 2011 |
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.
Topics: Administration, Intranasal; Administration, Oral; Animals; Anti-Allergic Agents; Capsaicin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Female; Guinea Pigs; Male; Nasal Mucosa; Parasympathetic Nervous System; Parasympatholytics; Particle Size; Pyrrolidines; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Secretory Pathway; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels; Urea | 2013 |
Activation of the TRPV1 channel attenuates N-methyl-D-aspartic acid-induced neuronal injury in the rat retina.
Topics: Animals; Capsaicin; Cell Survival; Green Fluorescent Proteins; Injections, Intraperitoneal; Intravitreal Injections; Male; Mice; Mice, Transgenic; N-Methylaspartate; Pyridines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; TRPV Cation Channels; Urea | 2014 |
Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Capsaicin; Dental Pulp; Hippocampus; Ibuprofen; Incisor; Learning Disabilities; Male; Maze Learning; Memory Disorders; Naphthyridines; Nerve Tissue Proteins; Nociception; Orexin Receptors; Orexins; Pain Measurement; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Single-Blind Method; Toothache; Urea | 2015 |
Systemic and local effects of intragastric administration of the habanero fruit (Capsicum chinense Jacquin c.v.) in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Capsaicin; Capsicum; Cholesterol; Creatinine; Fruit; Gastrointestinal Tract; Male; Plant Extracts; Rats; Rats, Wistar; Urea | 2015 |
The role of trigeminal nucleus caudalis orexin 1 receptors in orofacial pain transmission and in orofacial pain-induced learning and memory impairment in rats.
Topics: Animals; Benzoxazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Learning Disabilities; Male; Maze Learning; Memory Disorders; Motor Activity; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Sensory System Agents; Spatial Learning; Trigeminal Nuclei; Urea | 2016 |
The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat.
Topics: Animals; Anxiety; Benzoxazoles; Capsaicin; Disease Models, Animal; Exploratory Behavior; Facial Pain; Formaldehyde; Male; Maze Learning; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pain Measurement; Rats; Rats, Wistar; Time Factors; Trigeminal Nuclei; Urea | 2016 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
The research of the possible mechanism and the treatment for capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea | 2018 |
Arvanil, olvanil, AM 1172 and LY 2183240 (various cannabinoid CB1 receptor agonists) increase the threshold for maximal electroshock-induced seizures in mice.
Topics: Animals; Arachidonic Acids; Benzamides; Brain; Brain Waves; Cannabinoid Receptor Agonists; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Heterocyclic Compounds, 1-Ring; Male; Mice; Receptor, Cannabinoid, CB1; Seizures; Signal Transduction; Urea | 2018 |
Orexin-1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory.
Topics: Animal Experimentation; Animals; Benzoxazoles; Capsaicin; Dental Pulp; Dose-Response Relationship, Drug; Male; Medulla Oblongata; Naphthyridines; Nociception; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Rats; Rats, Wistar; Sensory System Agents; Spatial Learning; Spatial Memory; Urea | 2018 |
Activation of orexin-1 receptors in the ventrolateral periaqueductal grey matter (vlPAG) modulates pulpal nociception and the induction of substance P in vlPAG and trigeminal nucleus caudalis.
Topics: Animals; Benzoxazoles; Bicuculline; Capsaicin; Dental Pulp; Fluorescent Antibody Technique; Male; Naphthyridines; Nociception; Orexins; Periaqueductal Gray; Rats; Rats, Wistar; Substance P; Trigeminal Nuclei; Urea | 2019 |
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Models, Animal; Female; Freund's Adjuvant; gamma-Aminobutyric Acid; Ganglia, Spinal; Hindlimb; Inflammation; Isoquinolines; Mice, Inbred C57BL; Motor Activity; Receptor, trkA; Sensory Receptor Cells; TRPV Cation Channels; Urea | 2018 |
The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain.
Topics: Animals; Benzoxazoles; Brain-Derived Neurotrophic Factor; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Facial Pain; Hippocampus; Male; Naphthyridines; Neurons; Orexin Receptors; Orexins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Urea | 2018 |
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; Pain; Piperazine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2021 |
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors.
Topics: Analgesics; Animals; Capsaicin; Cyclophosphamide; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Mice; Urea; Visceral Pain | 2022 |