capsaicin has been researched along with resiniferatoxin in 296 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.01) | 18.7374 |
| 1990's | 100 (33.78) | 18.2507 |
| 2000's | 130 (43.92) | 29.6817 |
| 2010's | 60 (20.27) | 24.3611 |
| 2020's | 3 (1.01) | 2.80 |
| Authors | Studies |
|---|---|
| Aiyar, J; Auperin, DD; Chandy, KG; Grissmer, S; Gutman, GA; Hanson, DC; Karmilowicz, MJ; Mather, RJ; Nguyen, AN | 1 |
| Caterina, MJ; Julius, D; Levine, JD; Rosen, TA; Schumacher, MA; Tominaga, M | 1 |
| Brandriff, B; Cahalan, M; Chandy, G; Chandy, KG; Copeland, NG; Dukes, ID; Gutman, GA; Hustad, CM; Jenkins, NA; Kalman, K; Mohrenweiser, H; Nguyen, A; Tseng-Crank, J | 1 |
| Anthes, JC; Correll, CC; Greenfeder, S; Phelps, PT; Umland, S | 1 |
| Jeftinija, K; Jeftinija, S; Liu, F; Urban, L | 1 |
| Franco-Cereceda, A; Lou, YP; Lundberg, JM | 3 |
| Castle, NA | 1 |
| Evans, AT; Evans, FJ; Gordge, PC; Sahni, V | 1 |
| Håkanson, R; Wang, ZY | 1 |
| Bevan, S; Hothi, S; Hughes, G; James, IF; Rang, HP; Shah, K; Walpole, CS; Yeats, JC | 1 |
| Blumberg, PM; Lewin, NE; Szallasi, A | 1 |
| Foot, E; Leighton, B | 1 |
| Blumberg, PM; Szallasi, A | 7 |
| Kangrga, I; Randić, M | 1 |
| O'Neill, TP | 1 |
| Franco-Cereceda, A; Karlsson, JA; Lou, YP; Lundberg, JM | 1 |
| Barthó, L; Pethö, G; Szolcsányi, J | 1 |
| Franco-Cereceda, A | 1 |
| Amann, R; Giuliani, S; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M | 1 |
| Blumberg, PM; Szallasi, A; Szallasi, Z; Szolcsanyi, J | 1 |
| Blumberg, PM; Joo, F; Szallasi, A; Szallasi, Z; Szolcsanyi, J | 2 |
| Bevan, S; Dray, A; Winter, J; Wood, JN; Yeats, JC | 1 |
| Bettaney, J; Dray, A; Forster, P | 1 |
| Szolcsànyi, J | 1 |
| Blumberg, PM; Joo, F; Szallasi, A | 1 |
| Blumberg, PM; de Vries, DJ | 1 |
| Carlisi, VJ; Craft, RM; Herman, RM; Mattia, A; Porreca, F | 1 |
| Acs, G; Blumberg, PM; Palkovits, M | 4 |
| Goso, C; Manzini, S; Szallasi, A | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 1 |
| Blumberg, PM; Lundberg, JM; Szallasi, A | 1 |
| Burgess, GM; Davis, C; Harvey, JS; James, IF | 1 |
| Cohen, SM; Craft, RM; Porreca, F | 1 |
| Blumberg, PM; Conte, B; Goso, C; Manzini, S; Szallasi, A | 1 |
| Nagy, J; Pethö, G; Szolcsányi, J | 1 |
| Foot, EA; Leighton, B | 1 |
| Andrews, PL; Gupta, AN; Stock, MJ; Wong, TT; Woods, AJ | 1 |
| Blumberg, PM; Hökfelt, T; Lundberg, JM; Nilsson, S; Szallasi, A | 2 |
| Conte, B; Goso, C; Manzini, S; Parlani, M; Szallasi, A | 1 |
| Agoston, D; Jakab, G; Szallasi, A | 1 |
| Goso, C; Szallasi, A | 1 |
| Bevan, S; Boelsterli, JJ; Bovermann, G; Breckenridge, R; Davies, JW; Hughes, GA; James, I; Oberer, L; Walpole, CS; Winter, J | 1 |
| Acs, G; Blumberg, PM | 1 |
| Bennett, KL; Clark, MG; Colquhoun, EQ; Dora, KA; Eldershaw, TP | 1 |
| Lai, YL; Zhang, HQ | 2 |
| Abelli, L; Evangelista, S; Nappi, F; Panerai, C; Renzi, D; Surrenti, C; Tramontana, M | 1 |
| Higgins, KS; Laude, EA; Morice, AH | 1 |
| Blumberg, PM; Goso, C; Manzini, S; Szallasi, A | 1 |
| Blumberg, PM; Evangelista, S; Goso, C; Manzini, S; Szallasi, A; Tramontana, M | 1 |
| Ellis, JL; Undem, BJ | 1 |
| Bevan, S; James, IF; Walpole, CS; Winter, J | 1 |
| Gainer, H; Kusano, K | 1 |
| Andrews, PL; Bhandari, P | 1 |
| Aronov, EV; Brand, JG; Bryant, BP; Feigin, AM; Teeter, JH | 1 |
| Mózsik, G; Salam, OM; Szolcsányi, J | 1 |
| Bevan, S; Bloomfield, G; Breckenridge, R; James, IF; Ritchie, T; Szallasi, A; Walpole, CS; Winter, J; Wrigglesworth, R | 1 |
| Acs, G; Blumberg, PM; Lee, J; Marquez, VE | 1 |
| Furey, G; Sanger, GJ; Wardle, KA | 1 |
| Lundberg, JM; Rinder, J; Szallasi, A | 1 |
| Hwang, SW; Kim, D; Oh, U | 1 |
| Bennett, GJ; Blumberg, PM; Farkas-Szallasi, T; Hökfelt, T; Lundberg, JM; Szallasi, A | 1 |
| Szallasi, A | 3 |
| Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
| Abdel Salam, OM; Mózsik, G; Pórszász, R; Szolcsányi, J | 1 |
| Acs, G; Acs, P; Bíró, T; Blumberg, PM; Jonassohn, M; Sterner, O; Szallasi, A | 1 |
| Larm, JA; Lawen, A; Moutsoulas, P; Wolvetang, EJ | 1 |
| Aggarwal, BB; Natarajan, K; Singh, S | 1 |
| Ellis, JL; Sham, JS; Undem, BJ | 1 |
| Appendino, G; Szallasi, A | 1 |
| Farkas-Szallasi, T; Hökfelt, T; Lundberg, JM; Szallasi, A; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Abdel Salam, OM; Mózsik, G; Szolcsányi, J | 1 |
| Ranson, J; Sanger, GJ; Wardle, KA | 1 |
| Fukuda, H; Koga, T; Shiroshita, Y | 1 |
| Acs, G; Acs, P; Biro, T; Blumberg, PM; Modarres, S | 1 |
| Liu, L; Simon, SA; Szallasi, A | 1 |
| Blázquez, MV; Macho, A; Muñoz, E; Navas, P | 1 |
| Acs, P; Bíró, T; Blumberg, PM; Brodie, C; Lewin, NE; Modarres, S | 1 |
| Bíró, T; Blumberg, PM; De Rosa, S; Garlaschelli, L; Jonassohn, M; Klusch, A; Krause, JE; Modarres, S; Petersen, M; Sterner, O; Szallasi, A; Vidari, G | 1 |
| Cruz, F | 3 |
| Beneforti, P; Lazzeri, M; Spinelli, M; Turini, D; Zanollo, A | 1 |
| Farkas-Szallasi, T; Hökfelt, T; Krause, JE; Lundberg, JM; Szallasi, A; Tucker, JB | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Komiyama, I; Nishizawa, O | 1 |
| Bian, D; Lai, J; Malan, TP; Ossipov, MH; Porreca, F | 1 |
| Bíró, T; Blumberg, PM; Klusch, A; Krause, JE; Modarres, S; Petersen, M; Sterner, O; Szabó, T; Szallasi, A | 1 |
| Chancellor, MB; de Groat, WC | 1 |
| Németh, J; Peitl, B; Pethô, G; Pórszász, R; Szolcsányi, J | 1 |
| Annicelli, LL; Blumberg, PM; Cortright, DN; Krause, JE; Szallasi, A | 1 |
| Appendino, G; Bíró, T; Blumberg, PM; Cortright, DN; Krause, JE; Modarres, S; Szabó, T; Szallasi, A | 1 |
| Abdel-Salam, OM; Debreceni, A; Mózsik, G; Szolcsányi, J | 1 |
| Chancellor, MB; Kim, DY | 1 |
| Basbaum, AI; Caterina, MJ; Julius, D; Koltzenburg, M; Leffler, A; Malmberg, AB; Martin, WJ; Petersen-Zeitz, KR; Trafton, J | 1 |
| Fowler, CJ | 1 |
| Brough, SJ; Davis, JB; Harries, MH; Jerman, JC; Prinjha, R; Smart, D | 1 |
| Baert, L; De Ridder, D | 1 |
| Farkas, B; Helyes, ZS; Németh, J; Oroszi, G; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| Appendino, G; Blanco, M; Calzado, MA; Donnay, I; Lucena, C; Macho, A; Muñoz, E | 1 |
| Andrews, PL; Hagiwara, H; Kakaimoto, S; Matsuki, N; Okada, F; Toyoda, M; Woods, AJ | 1 |
| Janni, G; Jasmin, L; Ohara, PT; Rabkin, SD | 1 |
| Di Marzo, V; Szallasi, A | 1 |
| Cruz, F; Rio, ME; Silva, C | 1 |
| Foged, C; Thomsen, C; Tullin, S; Wahl, P | 1 |
| Cho, H; Cho, SY; Hwang, SW; Kwon, MJ; Lee, SY; Oh, U; Shin, JS; Wang, MH | 1 |
| Avelino, A; Cruz, F | 2 |
| Bisogno, T; Davis, JB; De Petrocellis, L; Di Marzo, V; Finazzi-Agro, A; Maccarrone, M | 1 |
| Brough, SJ; Cairns, W; Davis, JB; Gunthorpe, MJ; Hayes, PD; Jerman, JC; Randall, AD; Ranson, J; Smart, D | 1 |
| Rudd, JA; Wai, MK | 1 |
| Ajioka, H; Matsuura, N; Nakano, M; Nishihara, K; Nozawa, Y; Yamamoto, A | 1 |
| Beckel, JM; Chancellor, MB; Chuang, YC; de Groat, WC; Fraser, MO; Nakanishi, Y; Seki, S; Yokoyama, H; Yoshimura, N; Yu, Y | 1 |
| Kohama, K; Nakamura, A; Shirakura, K; Sudo, M; Takagishi, K; Tomioka, A; Tsutsumi, S | 1 |
| Davis, JB; De Petrocellis, L; Di Marzo, V | 1 |
| Birder, LA; Burke, NE; Caterina, MJ; de Groat, WC; Dineley, KE; Kanai, AJ; Kiss, S; Nealen, ML; Reynolds, IJ; Watkins, S | 1 |
| Mózsik, G; Szolcsányi, J; Vincze, A | 1 |
| Blumberg, PM; Kuzhikandathil, EV; Morozova, N; Oxford, GS; Szabo, T; Wang, H | 1 |
| Al-Hayani, A; Davies, SN; Pertwee, RG; Ross, RA; Wease, KN | 1 |
| Dubin, AE; Grant, ER; Zhang, SP; Zhong, Z; Zivin, RA | 1 |
| Kobata, K; Sakurada, N; Watanabe, T | 1 |
| Biro, T; Blumberg, PM; Gonzalez, AF; Palkovits, M; Szabo, T | 1 |
| Cannon, TW; Chancellor, MB | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Nocerino, E; Pinto, A; Sautebin, L | 1 |
| Di Stasi, SM; Giannantoni, A; Mearini, E; Navarra, P; Porena, M; Scivoletto, G; Stephen, RL | 1 |
| Hama, AT | 1 |
| Bradley, EL; Bright, CA; Kissin, I | 1 |
| Ghoniem, GM | 1 |
| Blumberg, PM; Kedei, N; Szabó, T; Tóth, A; Wang, Y | 1 |
| Hail, N; Lotan, R | 1 |
| Cho, H; Hwang, SW; Jung, J; Kang, YS; Kim, S; Lee, SY; Oh, U; Shin, J | 1 |
| Blumberg, PM; Kang, SU; Lee, J; Suh, YG; Szabo, T; Toth, A; Tran, R; Wang, Y; Welter, JD | 1 |
| Brough, SJ; Davis, JB; Egerton, J; Jerman, JC; Ralevic, V; Smart, D | 1 |
| Fowler, CJ; Fry, CH; Harper, M | 1 |
| Andersson, KE; Hedlund, P | 1 |
| Schilling, WP; Sinkins, WG; Wisnoskey, BJ | 1 |
| Li, GD; Zhao, ZQ; Zhou, Y | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Nishizawa, O; Zhang, X | 1 |
| Blumberg, PM; Kedei, N; Tóth, A; Wang, Y | 1 |
| de Ridder, D; Ost, D; Van der Aa, F | 1 |
| Chapple, CR; Chess-Williams, R; Kumar, V; Templeman, L | 1 |
| Chen, SR; Li, DP; Pan, HL; Zahner, MR | 1 |
| Kakizaki, H; Koyanagi, T; Mitsui, T; Shibata, T; Tanaka, H | 1 |
| Aihara, E; Kato, S; Kohama, K; Matsui, H; Nakamura, A; Takeuchi, K; Xin, H | 1 |
| Chen, CW; Fu, WM; Ho, FM; Lee, ST; Lin, WW; Wu, WT | 1 |
| Cassar, SC; Esbenshade, T; Hancock, AA; Masters, JN; Witte, DG | 1 |
| Cho, H; Hwang, SW; Jung, J; Koo, J; Lee, SY; Oh, U; Shin, JS | 1 |
| Barat, M; Blajezewski, S; Brochet, B; de Sèze, M; de Sèze, MP; Dosque, JP; Joseph, PA; Mazaux, JM; Moore, N; Soyeur, L; Wiart, L | 1 |
| Bevan, S; McIntyre, P; Phillips, E; Reeve, A | 1 |
| Lazzeri, M; Spinelli, M; Turini, D; Zanollo, A | 1 |
| Chou, MZ; Gao, YD; Kohler, M; Middleton, RE; Mtui, T | 1 |
| Aitken, RJ; Baker, MA; McLaughlin, EA; Ryan, AL | 1 |
| Premkumar, LS; Puntambekar, P; Raisinghani, M; Ramkumar, V; Van Buren, J | 1 |
| el-Mahrouky, AS; Elashry, OM; Emran, MA | 1 |
| Belai, A; Horie, S; Michael, GJ; Murayama, T; Priestley, JV; Uchida, M; Watanabe, K; Yamamoto, H | 1 |
| Berridge, MV; Herst, PM; Scarlett, DJ; Tan, AS | 1 |
| Li, J; Maile, MD; Sinoway, AN; Sinoway, LI | 1 |
| Bizik, F; Blumberg, PM; Kedei, N; Kozikowski, AP; Pearce, LV; Petukhov, PA; Szabo, T | 1 |
| Nagao, M; Shimada, S; Ueda, T; Ugawa, S; Yamamura, H | 1 |
| Pappalardo, A; Patti, F; Reggio, A | 1 |
| Dogan, MD; Patel, S; Romanovsky, AA; Rudaya, AY; Steiner, AA; Székely, M | 1 |
| Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C | 1 |
| Desimone, JA; Ghosh, S; Heck, GL; Lyall, V; Phan, TH; Vinnikova, AK | 1 |
| Iadarola, M; Karai, L; Lonser, RR; Olah, Z; Oldfield, EH; Tender, GC; Walbridge, S | 1 |
| Blumberg, PM; Choi, HK; Jin, MK; Kang, SU; Kedei, N; Lee, J; Pearce, LV; Tóth, A; Tran, R; Wang, Y | 1 |
| André, E; Calixto, JB; Ferreira, J; Kassuya, CA | 1 |
| Anthes, JC; Correll, CC; Phelps, PT | 1 |
| Carmena, MJ; Collado, B; Diaz-Laviada I, I; Malagarie-Cazenave, S; Olea, N; Prieto, JC; Sanchez, AM; Sanchez, MG | 1 |
| Desimone, JA; Heck, GL; Lyall, V; Malik, SA; Mummalaneni, S; Phan, TH; Vinnikova, AK | 1 |
| Caterina, MJ; Horiuchi, N; Iida, T; Shimizu, I | 1 |
| Pabbidi, RM; Premkumar, LS; Raisinghani, M | 1 |
| Adler-Graschinsky, E; Briones, R; Huidobro-Toro, JP; Orliac, ML; Poblete, IM | 1 |
| Gao, Z; Henig, O; Kehoe, V; Li, J; Sinoway, LI | 1 |
| Agate, B; Brown, CT; Carr, JL; Conway, SJ; Gallagher, KA; Paterson, S; Scott, RH; Van Ryssen, MP; Wease, KN | 1 |
| Baamonde, A; García, E; García-Suárez, O; Hidalgo, A; Juárez, L; Menéndez, L | 1 |
| Fujimoto, S; Kunimatsu, M; Mori, M; Tsushima, H | 1 |
| Calixto, JB; Ferreira, J; Mattos, WM; Niero, R; Richetti, GP; Yunes, RA | 1 |
| Fu, Y; Kochukov, MY; McNearney, TA; Westlund, KN | 1 |
| Beitz, AJ; Choi, SM; Han, HJ; Kang, SY; Kim, HW; Kim, KW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Ryu, YH; Yoon, SY | 1 |
| Amadesi, S; Andre, E; Bunnett, NW; Dinh, TQ; Fischer, A; Gatti, R; Geppetti, P; Harrison, S; Trevisani, M | 1 |
| Cunha, RA; Köfalvi, A; Oliveira, CR | 1 |
| Andresen, MC; Fan, W; Reynolds, PJ | 1 |
| Chartier-Kastler, E; Corcos, J; Denys, P; Everaert, K; Fowler, C; Kalsi, V; Nitti, V; Schulte-Baukloh, H; Schurch, B | 1 |
| Andrade, EL; André, E; Calixto, JB; Ferreira, J | 1 |
| Beitz, AJ; Cho, KH; Choi, SM; Han, HJ; Kang, SY; Kim, HW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Ryu, YH; Yoon, SY | 1 |
| Knispel, HH; Schulte-Baukloh, H | 1 |
| Jin, BK; Kim, SR; Kim, SU; Oh, U | 1 |
| Ahern, GP; Matta, JA; Miyares, RL | 1 |
| Alexander, SP; Athanasiou, A; Bagiokou, D; Bates, TE; Guo, DA; Kendall, DA; Kumaran, NM; Layfield, R; Lobo, DN; Lophatanon, A; Muir, KA; Ray, DE; Smith, PA; Turner, AE; Vakilpour, S; Watson, SA; Westwell, AD | 1 |
| Johansen, ME; Lanza, DL; Moos, PJ; Reilly, CA; Sabnis, AS; Thomas, KC; Yost, GS | 1 |
| Davies, J; Hainsworth, AH; Lam, PM; Lambert, DG; Owen, DE; Smith, GD | 1 |
| Gyires, K; Helyes, Z; László, J; Sándor, K; Szolcsányi, J | 1 |
| Bagoly, T; Börzsei, R; Elekes, K; Helyes, Z; Márk, L; Németh, J; Pintér, E; Pozsgai, G; Reglodi, D; Szolcsányi, J; Tóth, G | 1 |
| Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Vetter, I; Wyse, BD | 1 |
| Ahern, GP; Matta, JA | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Feng, NH; Lee, HH; Ma, MC; Shiang, JC | 1 |
| Abu-Asab, M; Iadarola, MJ; Jenkins, AC; Karai, LJ; Mannes, AJ; Neubert, JK; Zawatski, L | 1 |
| Chiang, H; Hsieh, ST; Hsieh, YL; Tseng, TJ | 1 |
| Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J | 1 |
| Bahrenberg, G; Christoph, T; De Vry, J; Englberger, W; Erdmann, VA; Frech, M; Kögel, B; Kurreck, J; Röhl, T; Schiene, K; Schröder, W; Seibler, J | 1 |
| Fujiuchi, A; Toga, T | 1 |
| Cao, J; Li, HB; Mao, RR; Xu, L; Yang, Y; Zhang, JC | 1 |
| Hirata, T; Matsumura, Y; Takaoka, M; Tsuji, F; Ueda, K | 1 |
| Wang, Y | 1 |
| Bai, ZT; Cheng, M; Ji, YH; Jiang, F; Liu, T; Pang, XY | 1 |
| White, PF | 1 |
| Kissin, I | 1 |
| Kissin, I; Strichartz, G; Sugimoto, K | 1 |
| Jósvay, K; Kaszás, K; Kemény, L; Koncz, I; Kúsz, E; Letoha, T; Oláh, Z; Pecze, L; Prorok, J; Szabó, K; Széll, M; Tóth, A; Vizler, C | 1 |
| Chen, H; Chen, SR; Pan, HL; Zhou, HY | 1 |
| Gotoh, M; Homma, Y; Igawa, Y; Kakizaki, H; Nishizawa, O; Obara, K; Seki, N; Takeda, M; Yamaguchi, O; Yokoyama, O; Yoshida, M | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Eder, C; Schilling, T | 1 |
| Abshire, S; Kochukov, MY; Ma, F; McNearney, TA; Ponomareva, L; Westlund, KN; Yin, H; Zhang, L | 1 |
| Ciufifeda, M; Cortellini, P; Dinale, F; Frattini, A; Maestroni, U; Ziglioli, F | 1 |
| Evans, MS; Jeffry, JA; Parihar, A; Premkumar, LS; Sikand, P; Yu, SQ | 1 |
| Chang, S; Cheng, CL; Cheng, HY; Hsieh, SH; Hu, SJ; Li, SJ | 1 |
| Fujita, T; Jiang, CY; Kumamoto, E; Liu, T; Nakatsuka, T; Piao, LH; Yue, HY | 1 |
| Bölcskei, K; Dézsi, L; Petho, G; Szolcsányi, J; Tékus, V | 1 |
| Andrews, PL; Chu, KM; Ngan, MP; Percie du Sert, N; Rudd, JA; Wai, MK; Yeung, CK | 1 |
| Hoon, MA; Mishra, SK | 1 |
| Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR | 1 |
| Garry, MG; Leal, AK; Mitchell, JH; Murphy, MN; Smith, SA; Williams, MA | 1 |
| Beattie, RE; Knopp, K; Liu, B; Sher, E; Ursu, D | 1 |
| Aizawa, N; Andersson, KE; Igawa, Y; Iijima, K; Nishizawa, O; Wyndaele, JJ | 1 |
| Geraghty, DP; Heng, YJ; Kunde, DA; Saunders, CI | 1 |
| Cui, X; Guptill, V; Iadarola, M; Keller, JM; Khaibullina, A; Mannes, A; Quezado, ZM; Spornick, N | 1 |
| Blumberg, PM; Choi, S; Kang, DW; Lazar, J; Lee, J; Lee, JH; Lee, Y; Pavlyukovets, VA; Pearce, LV; Ryu, H | 1 |
| Almeida, MC; Balaskó, M; Dogan, MD; Eales, J; Gavva, NR; Molchanova, AY; Oliveira, DL; Patel, S; Pétervári, E; Romanovsky, AA; Steiner, AA; Székely, M; Wanner, SP | 1 |
| de Oliveira, SM; Ferreira, J; Gomez, MV; Hoffmeister, C; Rossato, MF; Trevisan, G | 1 |
| Iadarola, MJ; Mannes, AJ | 1 |
| Kissin, I; Szallasi, A | 1 |
| Blumberg, PM; Lee, J; Pearce, LV | 1 |
| Abooj, M; Bishnoi, M; Bosgraaf, CA; Premkumar, LS; Zhong, L | 1 |
| He, H; Liu, D; Luo, Z; Ma, L; Ma, S; Sun, J; Tepel, M; Zhao, Z; Zhong, J; Zhu, T; Zhu, Z | 1 |
| Compton, SJ; Cowen, M; Crow, C; Morice, AH; Ramachandran, R; Sadofsky, LR | 1 |
| Edwards, JG; Jensen, T | 1 |
| Fan, ZD; Gan, XB; Gao, XY; Xiong, XQ; Zhang, L; Zhu, GQ | 1 |
| Ichikawa, H; Muramatsu, T; Sahara, Y; Sato, M; Shibukawa, Y; Sobhan, U; Tazaki, M; Tsumura, M | 1 |
| Sheta, M; Szallasi, A | 1 |
| Athayde, ML; Boligon, AA; Ferreira, J; Guerra, GP; Klafke, JZ; Oliveira, SM; Rosa, F; Rossato, MF; Tonello, R; Trevisan, G; Walker, CI; Zanon, RB | 1 |
| Chen, WW; Gao, XY; Han, Y; Xiong, XQ; Zhang, F; Zhou, YB; Zhu, GQ | 1 |
| Bouyer, PG; Matthews, JB; Shen, L; Tang, X; Turner, JR; Weber, CR | 1 |
| Li, C; Liu, L; Pai, R; Pasricha, PJ; Shenoy, M; Zhu, Y | 1 |
| Fujita, T; Kumamoto, E; Mizuta, K; Nishikubo, Y; Tomohiro, D | 1 |
| Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C | 1 |
| Barbero, R; Cuniberti, B; Odore, R; Re, G; Vercelli, C | 1 |
| DeSimone, JA; Grider, JR; Lyall, V; Mummalaneni, S; Murthy, KS; Phan, TH; Ren, Z; Rhyu, MR | 1 |
| An, JM; Hong, S; Jin, HJ; Moon, SJ; Park, J | 1 |
| Brar, RS; Chebolu, S; Darmani, NA; McClanahan, B; Trinh, C; Zhong, W | 1 |
| Bae, JH; Kim, HY; Kim, KJ; Kim, SA; Lee, BH; Leem, JW; Ryu, YH; Steffensen, SC; Yang, CH | 1 |
| Chichorro, JG; Cruz, LS; Kopruszinski, CM | 1 |
| Foster, HE; Lake, AG | 1 |
| Bölcskei, K; Borbély, É; Botz, B; Csepregi, JZ; Helyes, Z; Kenyér, T; Kereskai, L; Kiss, T; Mócsai, A; Pintér, E; Szolcsányi, J | 1 |
| Amzel, LM; Caterina, MJ; Chung, MK; Munns, CH; Sanchez, YE | 1 |
| Dasgupta, P | 1 |
| Andresen, MC; Hofmann, ME | 1 |
| Chen, LH; Huang, Y; Li, JC; Liu, T; Peng, XY; Tian, B; Wang, XL | 1 |
| Bais, S; Churgin, MA; Fang-Yen, C; Greenberg, RM | 1 |
| Carnevale, V; Delemotte, L; Elokely, K; Klein, ML; Palovcak, E; Rohacs, T; Velisetty, P | 1 |
| Blum, W; Jósvay, K; Oláh, Z; Pecze, L; Petrovics, G; Schwaller, B; Vizler, C | 1 |
| Furube, E; Kittaka, H; Mannari, T; Miyata, S; Takayama, Y; Tominaga, M; Yoshida, A | 1 |
| Vu, S; Yang, F; Yarov-Yarovoy, V; Zheng, J | 1 |
| Bartus, É; Hetényi, A; Jósvay, K; Martinek, TA; Németh, L; Oláh, Z; Szakonyi, G; Wéber, E; Winter, Z | 1 |
| Aubdool, AA; Bátai, IZ; Brain, SD; Filotás, D; Hajna, Z; Helyes, Z; Nagy, L; Payrits, M; Pintér, E; Pozsgai, G; Sághy, É; Szőke, É | 1 |
| Hirokawa, T; Mori, Y; Ogawa, K; Ohbuchi, K; Warabi, E; Yamamoto, M | 1 |
| Camponogara, C; Casoti, R; Chipindo, OJ; de Oliveira, SM; De Prá, SD; Ferreira, J; Ferro, PR; Manfron, MP; Milioli, AM; Rigo, FK; Trevisan, G | 1 |
| Borbély, É; Dénes, Á; Gaszner, B; Helyes, Z; Hunyady, Á; Környei, Z; Scheich, B; Szőke, É; Szolcsányi, J; Vincze, P | 1 |
| Araya, EI; Chichorro, JG; Cunha, JMD; Ferreira, LEN; Kopruszinski, CM; Nones, CFM | 1 |
| Ambrus, L; Bíró, T; Kelemen, B; Szabó, T; Tóth, BI | 1 |
| Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Andresen, MC; Madden, CJ; Mohammed, M; Morrison, SF | 1 |
| Ma, S; Wang, DH; Yu, SQ | 1 |
| Geraghty, DP; Jurković, S; Kunde, DA; Yingchoncharoen, J | 1 |
| Borbély, É; Botz, B; Helyes, Z; Kiss, T; Pintér, E; Szabadfi, K; Szolcsányi, J | 1 |
| Adamante, G; Bellinaso, F; Camponogara, C; Casoti, R; Coelho, YO; da Silva Silveira, E; de Almeida, AS; De Prá, SD; Desideri, AV; Ferreira, J; Milioli, AM; Oliveira, SM; Rigo, FK; Santos, MFC; Trevisan, G | 1 |
| Belák, M; Bölcskei, K; Boldizsár, F; Borbély, É; Botz, B; Glant, T; Helyes, Z; Horváth, Á; Juhász, T; Karanyicz, E; Kiss, T; Rauch, T; Szentes, N; Zákány, R | 1 |
| Adams, DJ; Finol-Urdaneta, RK; McArthur, JR | 1 |
| Bölcskei, K; Botz, B; Helyes, Z; Horváth, ÁI; Kriszta, G; Mócsai, A | 1 |
| Lin, CL; Lu, CC; Lu, YY; Tsai, HP; Wu, CH; Wu, MK | 1 |
| Alexander, B; Baskaran, P; Bennis, J; Gustafson, N; Louis, S; Mohandass, A; Nemenov, MI; Premkumar, LS; Thyagarajan, B | 1 |
35 review(s) available for capsaicin and resiniferatoxin
| Article | Year |
|---|---|
Mechanism of capsaicin action: recent learnings.
Topics: Action Potentials; Animals; Capsaicin; Cells, Cultured; Cough; Diterpenes; Humans; Ion Channels; Nerve Fibers; Neurons, Afferent; Ruthenium Red | 1991 |
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.
Topics: Animals; Body Temperature Regulation; Capsaicin; Diterpenes; Nervous System; Nervous System Physiological Phenomena; Neurons, Afferent; Pain; Receptors, Cell Surface; Structure-Activity Relationship | 1990 |
Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules).
Topics: Animals; Binding Sites; Capsaicin; Diterpenes; Humans; Neural Pathways; Plants, Medicinal | 1993 |
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine.
Topics: Analgesics; Animals; Capsaicin; Diterpenes; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; Humans; Neurons, Afferent; Neuropeptides; Plant Extracts; Plants, Medicinal; Receptors, Drug | 1997 |
Vanilloid receptors: new insights enhance potential as a therapeutic target.
Topics: Animals; Capsaicin; Diterpenes; Down-Regulation; Humans; Rats; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship; Up-Regulation | 1996 |
Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.
Topics: Animals; Capsaicin; Dermatitis; Diterpenes; Ganglia, Spinal; Humans; Neurotoxins; Pain; Radioligand Assay; Receptors, Drug | 1997 |
Desensitization of bladder sensory fibers by intravesical capsaicin or capsaicin analogs. A new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitivity disorders.
Topics: Administration, Intravesical; Animals; Capsaicin; Diterpenes; Female; Humans; Nerve Fibers; Neurotoxins; Urinary Bladder; Urinary Bladder, Neurogenic; Urinary Incontinence | 1998 |
Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat the overactive bladder.
Topics: Administration, Intravesical; Animals; Capsaicin; Diterpenes; Humans; Neurotoxins; Urinary Bladder Diseases | 1999 |
Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents.
Topics: Afferent Pathways; Animals; Capsaicin; Cytoprotection; Diterpenes; Female; Gastric Acid; Gastric Mucosa; Laser-Doppler Flowmetry; Male; Microcirculation; Neurons, Afferent; Neurotoxins; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Ulcer | 1999 |
Intravesical neuromodulatory drugs: capsaicin and resiniferatoxin to treat the overactive bladder.
Topics: Administration, Intravesical; Capsaicin; Clinical Trials as Topic; Diterpenes; Humans; Neurotransmitter Agents; Urinary Incontinence | 2000 |
Intravesical treatment of overactive bladder.
Topics: Administration, Intravesical; Anesthetics, Local; Atropine; Capsaicin; Cholinergic Antagonists; Diterpenes; Humans; Mandelic Acids; Neurons, Afferent; Neurotoxins; Urinary Bladder Diseases; Urinary Incontinence | 2000 |
Vanilloids and the overactive bladder.
Topics: Animals; Capsaicin; Cats; Diterpenes; Humans; Rats; Reflex, Abnormal; Urinary Bladder Diseases; Urination Disorders | 2000 |
New perspectives on enigmatic vanilloid receptors.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Cannabinoid Receptor Modulators; Capsaicin; Diterpenes; Drug Design; Endocannabinoids; Forecasting; Ganglia, Spinal; Glycerides; Humans; Ligands; Nerve Tissue Proteins; Neurons, Afferent; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2000 |
Vanilloid receptor ligands: hopes and realities for the future.
Topics: Aged; Animals; Capsaicin; Diterpenes; Geriatrics; Humans; Molecular Biology; Receptors, Drug | 2001 |
Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analog: gastric acid secretion, gastric mucosal damage and protection.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Humans; Neurotoxins; Stomach Ulcer | 2001 |
Pharmacotherapy of the overactive bladder and advances in drug delivery.
Topics: Administration, Intravesical; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Botulinum Toxins; Capsaicin; Cholinergic Antagonists; Cresols; Cystitis, Interstitial; Diterpenes; Humans; Mandelic Acids; Neurotoxins; Phenylpropanolamine; Tolterodine Tartrate; Urinary Bladder; Urinary Bladder Diseases; Urination Disorders | 2002 |
Vanilloid receptor and detrusor instability.
Topics: Animals; Capsaicin; Diterpenes; Humans; Neurotoxins; Rats; Receptors, Drug; Urinary Bladder; Urinary Bladder Diseases | 2002 |
Vanilloid (capsaicin) receptors in health and disease.
Topics: Animals; Arachidonic Acids; Capsaicin; Disease; Diterpenes; Drug Therapy; Endocannabinoids; Health; Humans; Neurons; Pathology; Polyunsaturated Alkamides; Receptors, Drug | 2002 |
Pharmacologic perspective on the physiology of the lower urinary tract.
Topics: Animals; Capsaicin; Cats; Diterpenes; Humans; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Rats; Receptors, Purinergic; Tachykinins; Urinary Bladder; Urinary Bladder Diseases; Urinary Tract; Urinary Tract Physiological Phenomena; Urination; Urination Disorders; Urothelium | 2002 |
Recent developments in the management of detrusor overactivity.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Botulinum Toxins, Type A; Capsaicin; Diterpenes; Female; Humans; Muscarinic Antagonists; Potassium Channels; Tachykinins; Urinary Bladder; Urinary Bladder, Neurogenic; Urination | 2003 |
Mechanisms involved in new therapies for overactive bladder.
Topics: Animals; Arachidonic Acids; Botulinum Toxins, Type A; Capsaicin; Diterpenes; Endocannabinoids; Humans; Nerve Growth Factor; Neurotoxins; Polyunsaturated Alkamides; Receptors, Drug; Urinary Bladder; Urinary Incontinence | 2004 |
The effect of intravesical capsaicin and resiniferatoxin in neurogenic bladder dysfunction.
Topics: Administration, Intravesical; Animals; Capsaicin; Diterpenes; Humans; Urinary Bladder, Neurogenic; Urinary Incontinence | 2003 |
[Management of neuropathic bladder in multiple sclerosis].
Topics: Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Botulinum Toxins; Capsaicin; Cresols; Diterpenes; Electric Stimulation Therapy; Humans; Multiple Sclerosis; Muscarinic Antagonists; Phenylpropanolamine; Prognosis; Quality of Life; Time Factors; Tolterodine Tartrate; Urinary Bladder, Neurogenic; Urodynamics | 2004 |
Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.
Topics: Animals; Biological Products; Calcium Channels; Capsaicin; Diterpenes; Humans; Nociceptors; Pain; Receptors, Drug; Structure-Activity Relationship; TRPC Cation Channels | 2005 |
Improving the global management of the neurogenic bladder patient: part II. Future treatment strategies.
Topics: Algorithms; Botulinum Toxins, Type A; Cannabinoids; Capsaicin; Cholinergic Antagonists; Diterpenes; Humans; Muscarinic Antagonists; Treatment Outcome; Urinary Bladder, Neurogenic; Urinary Incontinence | 2006 |
TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications.
Topics: Animals; Arachidonic Acids; Capsaicin; Clinical Trials as Topic; Cystitis; Diterpenes; Endocannabinoids; Humans; Neurons, Afferent; Polyunsaturated Alkamides; TRPV Cation Channels; Urinary Tract; Urothelium | 2006 |
Neuromodulatory therapies in female pelvic medicine and reconstructive surgery: biological agents.
Topics: Botulinum Toxins; Capsaicin; Diterpenes; Female; Humans; Neurotoxins; Pelvic Floor; Treatment Outcome; Urinary Bladder; Urinary Bladder, Neurogenic; Urinary Incontinence | 2006 |
The functional regulation of TRPV1 and its role in pain sensitization.
Topics: Animals; Capsaicin; Diterpenes; Pain; Protein Kinases; TRPV Cation Channels | 2008 |
Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity.
Topics: Analgesia; Analgesics; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Nerve Fibers; Neural Conduction; Pain, Postoperative; Rats; TRPV Cation Channels | 2008 |
Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism.
Topics: Apoptosis; Calcium Signaling; Capsaicin; Caspases; Curcumin; Diterpenes; Enzyme Inhibitors; Humans; Male; Prostatic Neoplasms; TRPV Cation Channels | 2009 |
The vanilloid agonist resiniferatoxin for interventional-based pain control.
Topics: Animals; Capsaicin; Diterpenes; Humans; Pain; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials.
Topics: Animals; Capsaicin; Clinical Trials as Topic; Diterpenes; Drug Evaluation, Preclinical; Humans; Pain; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation.
Topics: Animals; Capsaicin; Chemistry, Pharmaceutical; Diterpenes; Drug Design; Drug Partial Agonism; Humans; Signal Transduction; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
Targeting TRPV1 for pain relief: limits, losers and laurels.
Topics: Analgesics; Animals; Capsaicin; Diterpenes; Drug Delivery Systems; Drug Design; Humans; Pain; TRPV Cation Channels | 2012 |
Use of vanilloids in urologic disorders.
Topics: Capsaicin; Cystitis, Interstitial; Diterpenes; Humans; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive | 2014 |
2 trial(s) available for capsaicin and resiniferatoxin
| Article | Year |
|---|---|
Intravesical capsaicin versus resiniferatoxin in patients with detrusor hyperreflexia: a prospective randomized study.
Topics: Administration, Intravesical; Adult; Capsaicin; Diterpenes; Female; Follow-Up Studies; Humans; Male; Neurotoxins; Prospective Studies; Urinary Incontinence | 2002 |
Intravesical capsaicin versus resiniferatoxin for the treatment of detrusor hyperreflexia in spinal cord injured patients: a double-blind, randomized, controlled study.
Topics: Administration, Intravesical; Adult; Capsaicin; Diterpenes; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurotoxins; Reflex, Abnormal; Spinal Cord Injuries; Urinary Bladder, Neurogenic | 2004 |
259 other study(ies) available for capsaicin and resiniferatoxin
| Article | Year |
|---|---|
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Topics: 3T3 Cells; Animals; Base Sequence; Benzopyrans; Capsaicin; Cell Line; Cells, Cultured; Charybdotoxin; Cloning, Molecular; Cromakalim; Diltiazem; Diterpenes; Elapid Venoms; Flecainide; Ion Channel Gating; Mice; Molecular Sequence Data; Nifedipine; Oligodeoxyribonucleotides; Peptides; Potassium Channels; Pyrroles; Scorpion Venoms; Sotalol | 1994 |
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
Topics: Afferent Pathways; Amino Acid Sequence; Animals; Calcium; Calcium Channels; Capsaicin; Capsicum; Cell Death; Cell Line; Cloning, Molecular; Drosophila Proteins; Electrophysiology; Hot Temperature; Humans; Insect Proteins; Ion Channel Gating; Ion Channels; Molecular Sequence Data; Neurons, Afferent; Neurotoxins; Nociceptors; Plants, Medicinal; Protons; Receptors, Drug; Sequence Homology, Amino Acid; Transient Receptor Potential Channels; Xenopus | 1997 |
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes; Cloning, Molecular; Electrophysiology; Humans; In Situ Hybridization; Ion Channel Gating; Islets of Langerhans; Mice; Mice, Inbred Strains; Molecular Sequence Data; Neurotoxins; Phylogeny; Potassium Channels; Sequence Analysis, DNA; Shaker Superfamily of Potassium Channels | 1998 |
Cloning and pharmacological characterization of mouse TRPV1.
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; Cell Line; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Enzyme Activation; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Intracellular Space; Ion Channels; Mice; Phorbol Esters; Phosphorylation; Rabbits; Rats; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; TRPV Cation Channels | 2004 |
Effect of capsaicin and resiniferatoxin on peptidergic neurons in cultured dorsal root ganglion.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Cell Differentiation; Culture Techniques; Diterpenes; Ganglia, Spinal; Immunohistochemistry; Neurons, Afferent; Substance P | 1992 |
Different ion channel mechanisms between low concentrations of capsaicin and high concentrations of capsaicin and nicotine regarding peptide release from pulmonary afferents.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Capsaicin; Diterpenes; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Lung; Male; Nerve Endings; Neurokinin A; Neurons, Afferent; Nicotine; omega-Conotoxins; Peptides; Peptides, Cyclic; Tetrodotoxin; Vagus Nerve | 1992 |
Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Guaiacol; Muscles; Potassium; Rats; Rats, Sprague-Dawley; Time Factors | 1992 |
Variable alpha 2-adrenoceptor-mediated inhibition of bronchoconstriction and peptide release upon activation of pulmonary afferents.
Topics: Adrenergic alpha-Agonists; Afferent Pathways; Animals; Bradykinin; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Electric Stimulation; Guinea Pigs; Imidazoles; In Vitro Techniques; Lung; Neurokinin A; Nicotine; Peptides; Quinoxalines; Vagus Nerve | 1992 |
The potent irritancy of the daphnane orthoester, resiniferatoxin, exhibits features of a mixed aetiology.
Topics: Animals; Capsaicin; Diterpenes; Erythema; Female; Irritants; Mice; Mice, Inbred Strains; Phorbol Esters | 1992 |
Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin.
Topics: Animals; Bradykinin; Capsaicin; Captopril; Diterpenes; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Rabbits; Substance P; Tachykinins; Tachyphylaxis; Thiorphan | 1992 |
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin.
Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Electrophysiology; gamma-Aminobutyric Acid; Ganglia, Spinal; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Vagus Nerve | 1992 |
Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum.
Topics: Animals; Binding Sites; Capsaicin; Cattle; Chickens; Chlorpromazine; Diterpenes; Guinea Pigs; Orosomucoid; Perissodactyla; Rats; Receptors, Drug; Species Specificity | 1992 |
Inhibition of insulin-stimulated glycogen synthesis in skeletal muscle by resiniferatoxin is probably due to a mechanism involving CGRP.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Glycogen; Insulin; Insulin Antagonists; Muscles; Rats | 1992 |
Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia.
Topics: Acetylcholinesterase; Animals; Capsaicin; Diterpenes; Ganglia, Spinal; Molecular Weight; Receptors, Neurotransmitter; Sensory Receptor Cells; Swine; Synaptic Membranes | 1991 |
Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by mu-opioids.
Topics: Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1991 |
Selectivity of ruthenium red in inhibiting bronchoconstriction and CGRP release induced by afferent C-fibre activation in the guinea-pig lung.
Topics: Animals; Bradykinin; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Citrates; Citric Acid; Cough; Diterpenes; Female; Guinea Pigs; Histamine; Lung; Male; Neurons, Afferent; Nicotine; Ruthenium Red; Smoking; Vagus Nerve | 1991 |
Capsaicin-sensitive bronchopulmonary receptors with dual sensory-efferent function: mode of action of capsaicin antagonists.
Topics: Animals; Blood Pressure; Bronchi; Bronchoconstriction; Capsaicin; Diterpenes; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Ruthenium Red; Sensory Receptor Cells; Trachea; Veratridine | 1991 |
Resiniferatoxin-, capsaicin- and CGRP-evoked porcine coronary vasodilatation is independent of EDRF mechanisms but antagonized by CGRP(8-37).
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Dactinomycin; Diterpenes; Methylene Blue; Neurokinin A; Nitric Oxide; Peptide Fragments; Substance P; Vasodilation | 1991 |
Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons.
Topics: Anesthesia; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Ear, External; In Vitro Techniques; Male; Muscle Contraction; Nerve Endings; Neurons, Afferent; Peripheral Nerves; Rabbits; Rats; Rats, Inbred Strains; Reflex; Ruthenium Red; Spinal Cord; Substance P; Urinary Bladder; Urination; Vas Deferens | 1990 |
Ruthenium-red inhibits CGRP release by capsaicin and resiniferatoxin but not by ouabain, bradykinin or nicotine in guinea-pig heart: correlation with effects on cardiac contractility.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Guinea Pigs; Myocardial Contraction; Myocardium; Neuropeptide Y; Nicotine; Ouabain; Ruthenium Red | 1991 |
Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity.
Topics: Animals; Binding Sites; Capsaicin; Cell Membrane; Diterpenes; Drug Interactions; Female; Ganglia, Spinal; Mice; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Characterization of vanilloid receptors in the dorsal horn of pig spinal cord.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; In Vitro Techniques; Phorbol Esters; Radioligand Assay; Spinal Cord; Structure-Activity Relationship; Swine | 1991 |
Resiniferatoxin. An ultrapotent neurotoxin of capsaicin-sensitive primary afferent neurons.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Heart Rate; Hot Temperature; Neurons; Neurotoxins; Pain; Rats | 1991 |
Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin.
Topics: Animals; Bradykinin; Calcium; Capsaicin; Cell Survival; Cells, Cultured; Chickens; Cyclic AMP; Cyclic GMP; Diterpenes; Ganglia, Spinal; Guanidine; Guanidines; Kinetics; Membrane Potentials; Neurons; Neurons, Afferent; Neurotoxins; Rats; Rubidium | 1990 |
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Cats; Diterpenes; Female; Heart Rate; Neurons, Afferent; Rats; Rats, Inbred Strains; Respiration | 1990 |
Resiniferatoxin, a potent capsaicin-like stimulator of peripheral nociceptors in the neonatal rat tail in vitro.
Topics: Alkaloids; Animals; Animals, Newborn; Bradykinin; Capsaicin; Diterpenes; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nociceptors; Peripheral Nerves; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred Strains; Regional Blood Flow; Staurosporine; Tail | 1990 |
Effect of capsaicin, resiniferatoxin and piperine on ethanol-induced gastric ulcer of the rat.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Diterpenes; Ethanol; Female; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stomach Ulcer | 1990 |
Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Capsaicin; Cell Membrane; Diterpenes; Female; Ganglia, Spinal; Kinetics; Phorbol Esters; Rats; Rats, Inbred Strains; Regression Analysis | 1990 |
Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog.
Topics: Animals; Body Temperature Regulation; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Tolerance; Ganglia, Spinal; Hypothermia; Mitochondria; Neurons, Afferent; Rats | 1989 |
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper.
Topics: Animals; Capsaicin; Diterpenes; Female; Hypothermia; Inflammation; Pain; Rats; Rats, Inbred Strains | 1989 |
Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin.
Topics: Animals; Body Temperature; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Tolerance; Female; Mice | 1989 |
Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat.
Topics: Administration, Intravesical; Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Grooming; Injections, Subcutaneous; Irritants; Rats; Rats, Sprague-Dawley; Ruthenium Red | 1993 |
Trifluoperazine modulates [3H]resiniferatoxin binding by human and rat vanilloid (capsaicin) receptors and affects 45Ca uptake by adult rat dorsal root ganglion neurones.
Topics: Animals; Antipsychotic Agents; Calcium; Calcium Radioisotopes; Capsaicin; Diterpenes; Female; Ganglia, Spinal; Humans; Hypothermia, Induced; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trifluoperazine; Tritium | 1995 |
Resiniferatoxin binding to vanilloid receptors in guinea pig and human airways.
Topics: Adult; Animals; Binding Sites; Bronchi; Capsaicin; Diterpenes; Female; Guinea Pigs; Humans; Male; Middle Aged; Neurotoxins; Receptors, Drug; Trachea; Tritium | 1995 |
Urodynamic effects of intravesical resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Diterpenes; Female; Neurotoxins; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Urethral Obstruction; Urinary Bladder; Urodynamics | 1995 |
Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Protons; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Time Factors | 1995 |
Activation of protein kinase C by the capsaicin analogue resiniferatoxin in sensory neurones.
Topics: Animals; Capsaicin; Cell Membrane; Cytosol; Diterpenes; Enzyme Activation; Ganglia, Spinal; Ionomycin; Male; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Long-lasting desensitization of bladder afferents following intravesical resiniferatoxin and capsaicin in the rat.
Topics: Administration, Intravesical; Afferent Pathways; Animals; Capsaicin; Cornea; Cystitis; Diterpenes; Evaluation Studies as Topic; Female; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Weight Gain | 1995 |
Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences.
Topics: Animals; Animals, Newborn; Capsaicin; Cricetinae; Denervation; Diterpenes; Guinea Pigs; In Vitro Techniques; Mesocricetus; Mice; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Species Specificity; Substance P; Urinary Bladder | 1993 |
Effect of CP-96,345 a non-peptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociception.
Topics: Action Potentials; Analgesics; Animals; Biphenyl Compounds; Capsaicin; Diterpenes; Hot Temperature; Injections, Spinal; Pain; Peripheral Nerves; Rats; Ruthenium Red; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Substance P | 1993 |
The role of the sensory peptide calcitonin-gene-related peptide(s) in skeletal muscle carbohydrate metabolism: effects of capsaicin and resiniferatoxin.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Glucose; In Vitro Techniques; Insulin; Kinetics; Male; Muscle, Skeletal; Neurons, Afferent; Rats; Rats, Wistar; Starvation | 1995 |
Thermoregulatory effects of resiniferatoxin in the rat.
Topics: Animals; Behavior, Animal; Body Temperature; Body Temperature Regulation; Capsaicin; Diterpenes; Hot Temperature; Hypothermia; Injections, Subcutaneous; Male; Neurotoxins; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Drug | 1994 |
Visualization by [3H]resiniferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man.
Topics: Animals; Autoradiography; Capsaicin; Diterpenes; Female; Ganglia, Spinal; Humans; In Vitro Techniques; Neurons; Neurotoxins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Species Specificity; Spinal Cord; Swine; Tritium | 1994 |
Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Muscle Relaxation; Muscle, Smooth; Neurotransmitter Agents; Norepinephrine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug; Sympathetic Nervous System; Tritium; Urethra | 1993 |
The calcitonin gene-related peptide (CGRP) phenotype is expressed early and up-regulated by resiniferatoxin (RTX) in mouse sensory neurons.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Ganglia, Spinal; Gene Expression; Mice; Neurons, Afferent; Neurotoxins; Phenotype; Protein Kinase C; Tetradecanoylphorbol Acetate; Up-Regulation | 1994 |
Characterization by [3H]resiniferatoxin binding of a human vanilloid (capsaicin) receptor in post-mortem spinal cord.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Membranes; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Drug; Spinal Cord | 1994 |
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Crystallography, X-Ray; Diterpenes; Ganglia, Spinal; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neurons, Afferent; Neurotoxins; Rats; Receptors, Drug; Structure-Activity Relationship | 1994 |
[3H]resiniferatoxin binding to pig dorsal horn membranes displays positive cooperativity.
Topics: Animals; Binding Sites; Capsaicin; Diterpenes; Female; Neurotoxins; Rats; Rats, Sprague-Dawley; Spinal Cord; Swine | 1994 |
Resiniferatoxin and piperine: capsaicin-like stimulators of oxygen uptake in the perfused rat hindlimb.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Hindlimb; Male; Nitroglycerin; Oxygen Consumption; Perfusion; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 1994 |
[3H]resiniferatoxin binding by the human vanilloid (capsaicin) receptor.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; Female; Humans; Kinetics; Medulla Oblongata; Nerve Tissue Proteins; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Species Specificity; Spinal Cord; Trigeminal Nuclei | 1994 |
Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat.
Topics: Animals; Axons; Binding Sites; Binding, Competitive; Capsaicin; Diterpenes; Female; Ganglia, Spinal; Kinetics; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Cord; Substrate Specificity; Tritium; Urinary Bladder; Vagus Nerve | 1994 |
Role of vagus nerves in resiniferatoxin-induced bronchoconstriction of guinea pigs.
Topics: Afferent Pathways; Animals; Bronchoconstriction; Capsaicin; Diterpenes; Guinea Pigs; Lung Compliance; Maximal Expiratory Flow-Volume Curves; Nerve Fibers; Tachykinins; Vagotomy; Vagus Nerve | 1993 |
Capsaicin-like effect of resiniferatoxin in the rat stomach.
Topics: Administration, Oral; Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Injections, Subcutaneous; Male; Neurons, Afferent; Neurotoxins; Rats; Stomach Ulcer; Vasoactive Intestinal Peptide | 1994 |
A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man.
Topics: Administration, Inhalation; Adult; Animals; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Cough; Diterpenes; Dose-Response Relationship, Drug; Dyspnea; Female; Guinea Pigs; Humans; Male; Middle Aged; Reflex; Respiration; Respiratory Function Tests | 1993 |
Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat.
Topics: Animals; Binding Sites; Binding, Competitive; Bronchi; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Membranes; Neurons; Rats; Receptors, Drug; Sensitivity and Specificity; Spinal Cord; Trachea; Tritium; Urinary Bladder | 1993 |
Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat.
Topics: Administration, Topical; Animals; Capsaicin; Colitis; Diterpenes; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trinitrobenzenesulfonic Acid | 1993 |
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea.
Topics: Animals; Capsaicin; Diterpenes; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins; Trachea | 1994 |
Characterization of resiniferatoxin binding sites on sensory neurons: co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia.
Topics: Animals; Autoradiography; Binding Sites; Calcium; Capsaicin; Cell Membrane; Diterpenes; Female; Ganglia, Spinal; Nerve Growth Factors; Neurons, Afferent; Rats; Rats, Sprague-Dawley | 1993 |
Modulation of voltage-activated Ca currents by pain-inducing agents in a dorsal root ganglion neuronal line, F-11.
Topics: Action Potentials; Animals; Bradykinin; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Line; Diterpenes; Electrophysiology; Ganglia, Spinal; Mice; Neurons; omega-Conotoxins; Pain; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetrodotoxin | 1993 |
Resinferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret.
Topics: Animals; Antiemetics; Behavior, Animal; Blood Pressure; Body Temperature; Capsaicin; Copper; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Female; Ferrets; Gagging; Heart Rate; Loperamide; Male; Radiation Injuries; Reflex; Respiration; Vomiting | 1993 |
Axon reflex in resiniferatoxin-induced bronchoconstriction of guinea pigs.
Topics: Analysis of Variance; Animals; Axons; Bronchoconstriction; Capsaicin; Chlorisondamine; Diterpenes; Dose-Response Relationship, Drug; Forced Expiratory Volume; Guinea Pigs; Lung Compliance; Male; Maximal Expiratory Flow Rate; Neural Conduction; Reflex; Tetrodotoxin; Time Factors; Total Lung Capacity; Vagus Nerve; Vital Capacity | 1993 |
Capsaicin and its analogs induce ion channels in planar lipid bilayers.
Topics: Benzylamines; Capsaicin; Diterpenes; Electric Conductivity; Fatty Acids; Ion Channels; Lipid Bilayers | 1995 |
Capsaicin and its analogue resiniferatoxin inhibit gastric acid secretion in pylorus-ligated rats.
Topics: Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Female; Gastric Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Stomach; Time Factors | 1995 |
Similarities and differences in the structure-activity relationships of capsaicin and resiniferatoxin analogues.
Topics: Analgesics; Animals; Calcium; Capsaicin; Cell Membrane; Cells, Cultured; Diterpenes; Female; Ganglia, Spinal; Models, Molecular; Molecular Conformation; Molecular Structure; Neurotoxins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Biological Transport; Calcium; Capsaicin; Cell Membrane; Cells, Cultured; Diterpenes; Female; Ganglia, Spinal; Kinetics; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Tritium | 1996 |
Pharmacological characterization of the vanilloid receptor in the rat isolated vas deferens.
Topics: Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Antagonism; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Receptors, Drug; Vas Deferens | 1996 |
Capsaicin-, resiniferatoxin-, and lactic acid-evoked vascular effects in the pig nasal mucosa in vivo with reference to characterization of the vanilloid receptor.
Topics: Animals; Capsaicin; Diterpenes; Female; Lactic Acid; Male; Nasal Mucosa; Neurotoxins; Receptors, Drug; Swine | 1996 |
Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons.
Topics: Acids; Animals; Animals, Newborn; Capsaicin; Cations; Cells, Cultured; Diterpenes; Ganglia, Spinal; Ion Channels; Models, Neurological; Neurons; Neurotoxins; Rats | 1996 |
Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration.
Topics: Animals; Autoradiography; Capsaicin; Diterpenes; Female; Galanin; Ganglia, Spinal; Lumbosacral Region; Neuronal Plasticity; Neurotoxins; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Drug; Vasoactive Intestinal Peptide | 1996 |
Autoradiographic visualization and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Bronchi; Capsaicin; Cricetinae; Diterpenes; Female; Guinea Pigs; Humans; Male; Mesocricetus; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Swine | 1995 |
Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Diterpenes; Female; Hyperesthesia; Hypesthesia; Neurons, Afferent; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord Injuries; Tail; Time Factors; Vocalization, Animal | 1996 |
Effect of capsaicin and resiniferatoxin on gastrointestinal blood flow in rats.
Topics: Animals; Blood Pressure; Capsaicin; Diterpenes; Guanethidine; Injections, Intravenous; Isoproterenol; Jejunum; Laser-Doppler Flowmetry; Male; Neurons, Efferent; Phentolamine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach; Sympathectomy, Chemical; Vagotomy; Vasodilator Agents | 1996 |
Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn.
Topics: Adult; Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Binding, Competitive; Capsaicin; Carbazoles; Diterpenes; Female; Humans; In Vitro Techniques; Membranes; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Trifluoperazine | 1996 |
The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety.
Topics: Aldehydes; Animals; Calcium; Calcium Radioisotopes; Capsaicin; Diterpenes; Eye; Female; Ganglia, Spinal; Humans; Irritants; Membranes; Neurons; Polycyclic Sesquiterpenes; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sensitivity and Specificity; Sesquiterpenes; Spinal Cord; Stimulation, Chemical; Terpenes; Tongue; Tritium | 1996 |
Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin.
Topics: Animals; Apoptosis; B-Lymphocytes; Calcineurin; Calmodulin-Binding Proteins; Capsaicin; Cell Line; Diterpenes; Enzyme Inhibitors; Humans; Membrane Proteins; Mice; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-bcl-2 | 1996 |
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents.
Topics: Capsaicin; Diterpenes; DNA-Binding Proteins; HeLa Cells; Humans; I-kappa B Proteins; Leukemia, Myelomonocytic, Acute; Neurotoxins; NF-kappa B; NF-KappaB Inhibitor alpha; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations.
Topics: Animals; Binding Sites; Brain; Capsaicin; Diterpenes; Female; Humans; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1996 |
Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi.
Topics: Adult; Benzamides; Bronchi; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Female; Humans; Male; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Piperidines; Tachykinins | 1997 |
Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies.
Topics: Animals; Behavior, Animal; Capsaicin; Diterpenes; Electrophysiology; Galanin; Ganglia, Spinal; Hot Temperature; In Situ Hybridization; Male; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord | 1997 |
The indomethacin-induced gastric mucosal damage in rats. Effect of gastric acid, acid inhibition, capsaicin-type agents and prostacyclin.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diterpenes; Epoprostenol; Female; Gastric Acid; Gastric Mucosa; Histamine; Hydrochloric Acid; Indomethacin; Isoproterenol; Laser-Doppler Flowmetry; Male; Microcirculation; Neurotoxins; Pentagastrin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Ulcer; Vasodilator Agents | 1997 |
Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Male; Nerve Endings; Neurons, Afferent; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord | 1997 |
Capsaicin in the 4th ventricle abolishes retching and transmission of emetic vagal afferents to solitary nucleus neurons.
Topics: Animals; Capsaicin; Diterpenes; Dogs; Female; Male; Neurons, Afferent; Solitary Nucleus; Vagus Nerve; Vomiting | 1997 |
A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Diterpenes; Kinetics; Membrane Potentials; Neurons, Afferent; Neurotoxins; Patch-Clamp Techniques; Phorbol Esters; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Trigeminal Ganglion | 1998 |
Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity.
Topics: Acetylcysteine; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cyclosporine; Diterpenes; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinases; NADH, NADPH Oxidoreductases; NFATC Transcription Factors; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53 | 1998 |
Specific vanilloid responses in C6 rat glioma cells.
Topics: Animals; Calcium Radioisotopes; Capsaicin; Cell Differentiation; Cell Division; Diterpenes; Glioma; Neurotoxins; Rats; Receptors, Drug; Tumor Cells, Cultured | 1998 |
Dialdehyde sesquiterpenes and other terpenoids as vanilloids.
Topics: Aldehydes; Animals; Benzaldehydes; Binding, Competitive; Calcium; Capsaicin; Diterpenes; Electrophysiology; Female; Ganglia, Spinal; Humans; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spinal Cord; Taste; Terpenes; Tongue; Tritium | 1998 |
Intravesical resiniferatoxin for the treatment of detrusor hyperreflexia refractory to capsaicin in patients with chronic spinal cord diseases.
Topics: Administration, Intravesical; Adult; Capsaicin; Diterpenes; Female; Humans; Male; Neurotoxins; Reflex, Abnormal; Spinal Cord Diseases; Time Factors; Urinary Bladder; Urinary Bladder, Neurogenic; Urodynamics | 1998 |
Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn.
Topics: Administration, Topical; Animals; Capsaicin; Diterpenes; Ganglia, Spinal; In Situ Hybridization; Injections, Subcutaneous; Male; Neurokinin-1 Receptor Antagonists; Neurotoxins; Pain Management; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribonucleases; RNA, Messenger; Spinal Cord; Substance P; Tachykinins | 1999 |
Effects of intravesical capsaicin and resiniferatoxin on distension-induced bladder contraction in conscious rats with and without chronic spinal cord injury.
Topics: Administration, Intravesical; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Female; Muscle Contraction; Muscle, Smooth; Neurotoxins; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Urinary Bladder | 1999 |
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Ligation; Male; Neurons, Afferent; Pain; Pain Measurement; Peripheral Nervous System; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Time Factors | 1999 |
A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors.
Topics: Animals; Basidiomycota; Binding, Competitive; Calcium; Calcium Radioisotopes; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Eye; Female; Ganglia, Spinal; Humans; Irritants; Male; Membrane Potentials; Membranes; Neurons; Patch-Clamp Techniques; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Taste; Tongue; Tritium | 1999 |
Capsaicin-insensitive sensory-efferent meningeal vasodilatation evoked by electrical stimulation of trigeminal nerve fibres in the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Diterpenes; Electric Stimulation; Indoles; Isoindoles; Laser-Doppler Flowmetry; Male; Meninges; Nasal Mucosa; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Neurotoxins; Peptide Fragments; Rats; Rats, Wistar; Regional Blood Flow; Serum Albumin, Radio-Iodinated; Trigeminal Nerve; Vasoactive Intestinal Peptide; Vasodilation | 1999 |
The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons.
Topics: Animals; Biological Transport; Calcium; Calcium-Binding Proteins; Capsaicin; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Diterpenes; Ganglia, Spinal; Humans; Neurons; Nociceptors; Rats; Receptors, Drug; Transfection; Tritium; TRPV Cation Channels; Vanillic Acid | 1999 |
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.
Topics: Animals; Calcium; Capsaicin; Cell Membrane; CHO Cells; Cloning, Molecular; Cricetinae; Diterpenes; DNA, Complementary; Female; Fluorescent Dyes; Ganglia, Spinal; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1999 |
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Topics: Animals; Body Temperature; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Ganglia, Spinal; Gene Targeting; Hot Temperature; Hydrogen-Ion Concentration; Inflammation; Mice; Mice, Knockout; Nerve Fibers; Neurons; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Receptors, Drug; Spinal Cord; TRPV Cation Channels | 2000 |
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.
Topics: Animals; Calcium; Capsaicin; Cell Line; Diterpenes; DNA, Recombinant; Dose-Response Relationship, Drug; Fluorometry; Humans; Hydrogen-Ion Concentration; Ligands; Phorbol Esters; Polycyclic Sesquiterpenes; Rats; Receptors, Drug; Ruthenium Red; Sesquiterpenes; Transfection | 2000 |
Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release.
Topics: Alkaloids; Animals; Benzodioxoles; Calibration; Capsaicin; Diterpenes; Electric Stimulation; Enzyme Inhibitors; Female; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Trachea | 1999 |
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism.
Topics: Apoptosis; Capsaicin; Caspase 3; Caspases; Cell Cycle; Diterpenes; DNA; Flow Cytometry; Genes, Reporter; HeLa Cells; Humans; In Situ Nick-End Labeling; Jurkat Cells; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinases; Molecular Structure; Phorbol Esters; Reactive Oxygen Species; Receptors, Drug; Transcription Factor AP-1; Transfection; TRPV Cation Channels | 2000 |
The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdomen; Animals; Animals, Newborn; Antiemetics; Behavior, Animal; Capsaicin; Cisplatin; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Motion Sickness; Nicotine; Piperidines; Proto-Oncogene Proteins c-fos; Serotonin Receptor Agonists; Shrews; Tropisetron; Vagotomy; Vomiting | 2000 |
CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat.
Topics: Administration, Intravesical; Analysis of Variance; Animals; Capsaicin; Cell Degranulation; Central Nervous System Viral Diseases; Cystitis; Denervation; Disease Models, Animal; Diterpenes; Histamine; Male; Mast Cells; Neurogenic Inflammation; Neurons, Afferent; Neurotoxins; Pseudorabies; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2000 |
Desensitization of bladder sensory fibers by intravesical resiniferatoxin, a capsaicin analog: long-term results for the treatment of detrusor hyperreflexia.
Topics: Administration, Intravesical; Adult; Aged; Capsaicin; Diterpenes; Female; Follow-Up Studies; Humans; Male; Middle Aged; Reflex, Abnormal; Time Factors; Urinary Bladder; Urinary Bladder Diseases | 2000 |
Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist.
Topics: Analgesics; Animals; Binding, Competitive; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Humans; Iodine Radioisotopes; Mice; Oocytes; Pain; Pain Measurement; Radioligand Assay; Receptors, Drug; Transfection; TRPV Cation Channels; Xenopus laevis | 2001 |
Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression Regulation; Humans; Ion Channels; Kidney; Neurons, Afferent; Phorbol Esters; Rats; Receptors, Drug; Transfection; TRPV Cation Channels | 2001 |
Peptide immunoreactivity and ultrastructure of rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Female; Male; Microscopy, Electron; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Pressure; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder; Urination; Vasoactive Intestinal Peptide | 2000 |
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism.
Topics: Arachidonic Acids; Biological Transport; Calcium; Cannabinoids; Capsaicin; Cell Line; Cell Membrane; Cytosol; Diterpenes; Endocannabinoids; Enzyme Inhibitors; Humans; Kinetics; Nitroprusside; Organophosphonates; Polyunsaturated Alkamides; Receptors, Drug; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2001 |
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
Topics: Alkaloids; Aniline Compounds; Arachidonic Acids; Benzophenanthridines; Calcium; Capsaicin; Cell Line; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Fluorescence; Fluorometry; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Phenanthridines; Polycyclic Sesquiterpenes; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Drug; Ruthenium Red; Sesquiterpenes; Time Factors; Xanthenes | 2001 |
Genital grooming and emesis induced by vanilloids in Suncus murinus, the house musk shrew.
Topics: Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Male; Sexual Behavior, Animal; Shrews; Time Factors; Vomiting | 2001 |
Distribution and characterization of vanilloid receptors in the rat stomach.
Topics: Animals; Binding Sites; Binding, Competitive; Blood Vessels; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enteric Nervous System; Gastric Mucosa; Immunohistochemistry; Myenteric Plexus; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Splanchnic Circulation; Stomach; Submucous Plexus; Tritium | 2001 |
Analysis of the afferent limb of the vesicovascular reflex using neurotoxins, resiniferatoxin and capsaicin.
Topics: Administration, Intravesical; Afferent Pathways; Animals; Arteries; Blood Pressure; Capsaicin; Dilatation; Diterpenes; Female; Injections, Subcutaneous; Muscle Contraction; Nerve Fibers; Neurotoxins; Rats; Rats, Sprague-Dawley; Reflex; Urinary Bladder; Urination | 2001 |
Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, Intravenous; Binding Sites; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Nervous System; Pain; Patch-Clamp Techniques; Propofol; Receptors, Drug | 2001 |
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors.
Topics: Amides; Arachidonic Acids; Calcium; Capsaicin; Cell Line; Diterpenes; Drug Synergism; Endocannabinoids; Ethanolamines; Humans; Palmitic Acids; Polyunsaturated Alkamides; Receptors, Drug | 2001 |
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Calcimycin; Capsaicin; Diterpenes; DNA Primers; Epithelial Cells; Immunohistochemistry; Nitric Oxide; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Urinary Bladder | 2001 |
Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation.
Topics: Amino Acid Substitution; Animals; Binding Sites; Capsaicin; CHO Cells; Conserved Sequence; Cricetinae; Diterpenes; Gene Expression; Genes, Dominant; Ion Channel Gating; Macromolecular Substances; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Binding; Protein Structure, Tertiary; Rats; Receptor Aggregation; Receptors, Drug; Sequence Homology, Amino Acid; Structure-Activity Relationship; Transfection; TRPV Cation Channels | 2001 |
The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice.
Topics: Action Potentials; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Diterpenes; Endocannabinoids; Glycerides; Hippocampus; In Vitro Techniques; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2001 |
Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: a method to resolve ionic dependence of VR1-mediated cell death.
Topics: Benzofurans; Calcium; Capsaicin; Cell Death; Cell Line; Cells, Cultured; Cloning, Molecular; Diterpenes; Ethers, Cyclic; Fluorescent Dyes; Fura-2; Humans; Hydrogen-Ion Concentration; Kidney; Neurotoxins; Reactive Oxygen Species; Receptors, Drug; Sodium; Transfection | 2002 |
Capsaicin-, resiniferatoxin-, and olvanil-induced adrenaline secretions in rats via the vanilloid receptor.
Topics: Adrenal Glands; Animals; Capsaicin; Diterpenes; Epinephrine; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2001 |
Pharmacological characterization of vanilloid receptor located in the brain.
Topics: Animals; Binding, Competitive; Brain Chemistry; Capsaicin; Diterpenes; Ganglia, Spinal; Hippocampus; Kinetics; Locus Coeruleus; Macaca fascicularis; Neurons, Afferent; Organ Specificity; Preoptic Area; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Structure-Activity Relationship; TRPV Cation Channels | 2002 |
Relaxant effect of capsazepine in the isolated rat ileum.
Topics: Alkaloids; Animals; Benzodioxoles; Calcium Channels, L-Type; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2002 |
Capsaicin-sensitive primary afferents mediate responses to cold in rats with a peripheral mononeuropathy.
Topics: Animals; Cannabinoids; Capsaicin; Cold Temperature; Diterpenes; Hindlimb; Hyperalgesia; Ligation; Male; Mononeuropathies; Neurons, Afferent; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2002 |
Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity.
Topics: Animals; Bupivacaine; Capsaicin; Carrageenan; Diterpenes; Hyperalgesia; Male; Nerve Block; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 2002 |
The recalcitrant overactive bladder patient.
Topics: Administration, Intravesical; Aged; Aged, 80 and over; Behavior Therapy; Botulinum Toxins; Capsaicin; Diterpenes; Electric Stimulation Therapy; Humans; Middle Aged; Muscle Denervation; Muscle Hypertonia; Neurotoxins; Randomized Controlled Trials as Topic; Urinary Bladder; Urinary Incontinence | 2002 |
Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Capsaicin; CHO Cells; Cloning, Molecular; Cricetinae; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Receptors, Drug; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; TRPV Cation Channels | 2002 |
Examining the role of mitochondrial respiration in vanilloid-induced apoptosis.
Topics: Apoptosis; Calcium; Capsaicin; Carcinoma, Squamous Cell; Cell Cycle; Diterpenes; DNA, Neoplasm; Female; Flow Cytometry; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Oxygen Consumption; Reactive Oxygen Species; Skin Neoplasms; Tumor Cells, Cultured | 2002 |
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1.
Topics: Animals; Arginine; Capsaicin; Cell Line; Cytoplasm; Cytosol; Diterpenes; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Gene Deletion; Glutamine; Hot Temperature; Humans; Immunoblotting; Immunohistochemistry; Ligands; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Drug; Recombinant Fusion Proteins; Time Factors; TRPV Cation Channels; Xenopus laevis | 2002 |
High affinity antagonists of the vanilloid receptor.
Topics: Animals; Binding, Competitive; Biological Transport; Calcium; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Diterpenes; Hot Temperature; Neurons; Protons; Rats; Receptors, Drug; Sulfonamides; Thiourea | 2002 |
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Topics: Alkaloids; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Humans; Indicators and Reagents; Mesenteric Arteries; Phenols; Phorbol Esters; Polycyclic Sesquiterpenes; Receptors, Drug; Recombinant Proteins; Ruthenium Red; Sensory Receptor Cells; Sesquiterpenes | 2003 |
Voiding and the sacral reflex arc: lessons from capsaicin instillation.
Topics: Afferent Pathways; Capsaicin; Diterpenes; Humans; Lumbosacral Plexus; Neurotoxins; Reflex; Urinary Bladder; Urination | 2002 |
Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry.
Topics: Animals; Arachidonic Acids; Baculoviridae; Barium; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cannabinoids; Capsaicin; Cells, Cultured; Diterpenes; Endocannabinoids; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Immunoblotting; Ion Transport; Microscopy, Confocal; Neurotoxins; Polyunsaturated Alkamides; Rats; Receptors, Drug; Recombinant Proteins; Thapsigargin; Transfection; TRPV Cation Channels; Type C Phospholipases | 2003 |
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Disease Models, Animal; Diterpenes; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Hyperalgesia; Inflammation; Ligation; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor over-activity induced by intravesical capsaicin, acetic acid or ATP in conscious rats.
Topics: Acetic Acid; Adenosine Triphosphate; Administration, Intravesical; Afferent Pathways; Animals; Capsaicin; Diterpenes; Drug Combinations; Female; Injections, Subcutaneous; Muscle Contraction; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Urinary Bladder; Urination; Urodynamics | 2003 |
Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channels; Capsaicin; Cell Line; CHO Cells; Cricetinae; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Kinetics; Ligands; Models, Chemical; Polyunsaturated Alkamides; Protein Binding; Rats; Receptors, Drug; Spinal Cord; Time Factors; Transfection | 2003 |
Intravesical ethanol 10% in saline is not an inert vehicle.
Topics: Administration, Intravesical; Animals; Capsaicin; Diterpenes; Ethanol; Muscle Hypertonia; Sodium Chloride; Solvents; Urinary Bladder, Neurogenic | 2003 |
Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats.
Topics: Animals; Blood Pressure; Bradykinin; Capsaicin; Diterpenes; Fluorescent Antibody Technique; Ganglia, Spinal; Heart; Hot Temperature; Kidney; Male; Microscopy, Confocal; Myocardium; Neurons, Afferent; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Drug; Reflex; Sympathetic Nervous System | 2003 |
Effect of preemptive treatment of capsaicin or resiniferatoxin on the development of pre-micturition contractions after partial urethral obstruction in the rat.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Female; Muscle Contraction; Muscle, Smooth; Neurotoxins; Organ Size; Rats; Rats, Wistar; Urethral Obstruction; Urinary Bladder | 2003 |
Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection.
Topics: Acids; Animals; Capsaicin; Diterpenes; Epithelial Cells; Ethanol; Gastric Mucosa; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; TRPV Cation Channels | 2003 |
Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.
Topics: Animals; Capsaicin; Cell Line; Cyclooxygenase 2; Dinoprostone; Diterpenes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Ganglia, Spinal; I-kappa B Kinase; Interferon-gamma; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Male; Mitogen-Activated Protein Kinases; Neurotoxins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factor AP-1 | 2003 |
Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
Topics: Amino Acid Sequence; Animals; Biological Assay; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Fluorescence; Humans; Kinetics; Ligands; Molecular Sequence Data; Rats; Receptors, Drug; Ruthenium Red; Sequence Homology, Amino Acid; Species Specificity | 2002 |
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.
Topics: Animals; Binding Sites; Biotinylation; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cell Line; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diterpenes; Humans; Immunoblotting; Kinetics; Ligands; Models, Biological; Mutagenesis, Site-Directed; Mutation; Neurons; Oocytes; Phosphorylation; Point Mutation; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, Drug | 2004 |
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Diterpenes; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Ions; Kinetics; Ligands; Methionine; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenotype; Phorbol Esters; Protein Structure, Tertiary; Rats; Receptors, Drug; Species Specificity; Time Factors | 2004 |
Intravesical vanilloids and neurogenic incontinence: ten years experience.
Topics: Administration, Intravesical; Adult; Aged; Capsaicin; Diterpenes; Female; Humans; Male; Middle Aged; Neurotoxins; Retrospective Studies; Spinal Cord Injuries; Treatment Outcome; Urinary Bladder, Neurogenic; Urinary Incontinence | 2004 |
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
Topics: Animals; Capsaicin; Cell Line; Diterpenes; Extracellular Fluid; Humans; Leucine; Ligands; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Neurotoxins; Point Mutation; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Drug; Recombinant Fusion Proteins; Species Specificity; Tritium | 2004 |
Redox activity associated with the maturation and capacitation of mammalian spermatozoa.
Topics: 4-Chloromercuribenzenesulfonate; Acridines; Acrosome Reaction; Animals; Arginine; Bicarbonates; Calcium; Capsaicin; Catalase; Culture Media; Deferoxamine; Diterpenes; Enzyme Inhibitors; Epididymis; Fructose; Glucose; Indicators and Reagents; Iron Chelating Agents; Luminol; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Onium Compounds; Oxidation-Reduction; Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Spermatozoa; Superoxide Dismutase; Temperature; Time Factors; Uncoupling Agents | 2004 |
Direct interaction of adenosine with the TRPV1 channel protein.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Binding, Competitive; Capsaicin; Cell Membrane; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Kidney; Neurons; Oocytes; Phenethylamines; Protein Binding; Rats; Receptors, Drug; Xenopus laevis | 2004 |
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Catechols; Diterpenes; Famotidine; Fatty Alcohols; Gastric Mucosa; Hydrochloric Acid; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Stomach Ulcer | 2004 |
Cell surface oxygen consumption by mitochondrial gene knockout cells.
Topics: Aerobiosis; Capsaicin; Cell Membrane; Cell Survival; Dicumarol; Diterpenes; Electron Transport; Flavins; HL-60 Cells; Humans; Mitochondria; NAD; NADP; Onium Compounds; Oxidation-Reduction; Oxygen Consumption; Tetrazolium Salts; Time Factors; Ubiquinone; Uncoupling Agents | 2004 |
Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel.
Topics: Acid Sensing Ion Channels; Animals; Arachidonic Acids; Baroreflex; Blood Pressure; Capsaicin; Diterpenes; Endocannabinoids; Heart Rate; Ion Channels; Lactic Acid; Male; Membrane Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Neurotoxins; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Sodium Channels; TRPV Cation Channels | 2004 |
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Topics: Animals; Calcium; Capsaicin; Cations, Divalent; CHO Cells; Cricetinae; Diterpenes; Ligands; Models, Biological; Molecular Conformation; Molecular Structure; Plant Extracts; Quinazolines; TRPV Cation Channels | 2004 |
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.
Topics: Amiloride; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diterpenes; Diuretics; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Epithelial Sodium Channels; Humans; Hydrogen-Ion Concentration; Neurotoxins; Oocytes; Protein Structure, Tertiary; Protons; Receptors, Drug; Sodium Channels; Xenopus | 2004 |
Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.
Topics: Animals; Body Temperature; Capsaicin; Diterpenes; Eating; Fever; Lipopolysaccharides; Male; Rats; Rats, Long-Evans; Receptors, Drug; TRPV Cation Channels | 2004 |
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydramine; Diterpenes; Domperidone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Indomethacin; Malates; Methysergide; Metoclopramide; Migraine Disorders; Ondansetron; Piperidines; Ruthenium Red; Scopolamine; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews; Sumatriptan; Time Factors; Tropanes; Vomiting | 2005 |
A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor.
Topics: Amiloride; Anilides; Animals; Capsaicin; Cinnamates; Diterpenes; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Salts; Sodium Channel Blockers; Sodium Chloride; Taste; Taste Buds; TRPV Cation Channels | 2005 |
Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation.
Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Immunohistochemistry; Macaca mulatta; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Trigeminal Ganglion | 2005 |
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Endocannabinoids; Fluorescent Dyes; Fura-2; Ion Channels; Kinetics; Polyunsaturated Alkamides; Rats; TRPV Cation Channels | 2005 |
Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1).
Topics: Amino Acid Sequence; Animals; Biological Transport; Calcium; Capsaicin; Cell Line; Cloning, Molecular; Diterpenes; DNA, Complementary; Dogs; Dopamine; Dose-Response Relationship, Drug; Fluorometry; Genetic Vectors; Genotype; Humans; Molecular Sequence Data; Mutation, Missense; Phorbol Esters; Phylogeny; Pyrazines; Pyridines; Receptors, Drug; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transfection | 2005 |
Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue.
Topics: Arachidonic Acids; Binding, Competitive; Blotting, Western; Calcium; Capsaicin; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Gene Expression; Humans; Iodine Radioisotopes; Ion Channels; Male; Prostate; Prostatic Neoplasms; Radioligand Assay; Reverse Transcriptase Polymerase Chain Reaction; TRPV Cation Channels | 2005 |
Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses.
Topics: Algorithms; Amiloride; Anilides; Animals; Capsaicin; Cell Membrane; Cell Polarity; Central Nervous System Depressants; Chorda Tympani Nerve; Cinnamates; Diterpenes; Diuretics; Ethanol; Female; In Vitro Techniques; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium; Sodium Chloride; Stimulation, Chemical; Taste; Taste Threshold; Temperature; Tongue | 2005 |
5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro.
Topics: Animals; Body Temperature; Calcium; Capsaicin; Diterpenes; Humans; Hypothermia; Ion Channels; Mice; Mice, Inbred C57BL; TRPV Cation Channels | 2005 |
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin.
Topics: Animals; Capsaicin; Diterpenes; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; Neurons; Oocytes; Patch-Clamp Techniques; Rats; Transfection; TRPV Cation Channels; Xenopus | 2005 |
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.
Topics: Anilides; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Capsaicin; Cinnamates; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitroarginine; Perfusion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; RNA, Messenger; TRPV Cation Channels; Vasodilation | 2005 |
Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Baroreflex; Blood Pressure; Capsaicin; Decerebrate State; Diterpenes; Dose-Response Relationship, Drug; Hindlimb; Male; Membrane Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Neurons, Afferent; Phosphoric Acids; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Sympathetic Nervous System; TRPV Cation Channels | 2006 |
In vitro photo-release of a TRPV1 agonist.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Electrophysiology; Humans; Ion Channels; Light; Models, Chemical; Neurons; Protein Binding; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2006 |
Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice.
Topics: Analgesics; Analysis of Variance; Animals; Bone Neoplasms; Capsaicin; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Freund's Adjuvant; Functional Laterality; Inflammation; Mice; Mice, Inbred C3H; Osteosarcoma; Pain; Pain Measurement; Reaction Time; Time Factors | 2006 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Charybdotoxin; Diclofenac; Dimethyl Sulfoxide; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitroarginine; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; rho-Associated Kinases; Tetraethylammonium; Vasodilator Agents | 2006 |
Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina.
Topics: Analgesics; Animals; Apocynaceae; Bradykinin; Capsaicin; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Diterpenes; Male; Mice; Pain Measurement; Plant Extracts; Pregnanes; Tetradecanoylphorbol Acetate | 2006 |
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.
Topics: Arthritis, Rheumatoid; Calcium; Calcium Channels; Calcium Signaling; Capsaicin; Cell Line, Tumor; Cells, Cultured; Chondrocalcinosis; Cytosol; Diterpenes; Hot Temperature; Humans; Inflammation; Nerve Tissue Proteins; Pyrimidinones; RNA, Messenger; Synovial Membrane; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2006 |
Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect.
Topics: Adrenergic Agents; Animals; Anti-Inflammatory Agents; Bee Venoms; Capsaicin; Disease Models, Animal; Diterpenes; Drug Interactions; Functional Laterality; Gene Expression; Inflammation; Leukocytes; Locus Coeruleus; Mice; Mice, Inbred ICR; Norepinephrine; Oncogene Proteins v-fos; Oxidopamine; Sciatic Neuropathy; Zymosan | 2006 |
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
Topics: Animals; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Diterpenes; Guinea Pigs; Indomethacin; Inflammation; Isoquinolines; Male; Neurons, Afferent; Protein Kinase C; Protein Kinase Inhibitors; Receptor, PAR-2; Saline Solution, Hypertonic; Sulfonamides; TRPV Cation Channels; Trypsin | 2006 |
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals.
Topics: Animals; Calcium; Capsaicin; Diterpenes; Fluorometry; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Potassium; Presynaptic Terminals; Rats; Rats, Wistar; Stereoisomerism; TRPV Cation Channels | 2006 |
Capsaicin-resistant arterial baroreceptors.
Topics: Action Potentials; Animals; Aorta, Thoracic; Capsaicin; Diterpenes; Drug Resistance; Male; Nerve Fibers, Unmyelinated; Osmolar Concentration; Pressoreceptors; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2006 |
Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.
Topics: Acrolein; Anilides; Animals; Ankyrins; Binding Sites; Calcium Channels; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Drug Antagonism; In Vitro Techniques; Isothiocyanates; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Ruthenium Red; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Urinary Bladder | 2006 |
Bee venom injection significantly reduces nociceptive behavior in the mouse formalin test via capsaicin-insensitive afferents.
Topics: Acupuncture Analgesia; Acupuncture Points; Afferent Pathways; Analgesics; Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Diterpenes; Drug Resistance; Locus Coeruleus; Male; Mice; Mice, Inbred ICR; Neurons, Afferent; Neurotoxins; Nociceptors; Norepinephrine; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Receptors, Adrenergic, alpha-2; Spinal Cord; Tyrosine 3-Monooxygenase | 2006 |
Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release.
Topics: Animals; Blotting, Western; Calcium; Capsaicin; Cell Death; Cell Line; Cytochromes c; Diterpenes; Enzyme Inhibitors; Humans; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Microglia; Mitochondria; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; TRPV Cation Channels | 2006 |
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.
Topics: Animals; Binding, Competitive; Calcium; Capsaicin; Cell Line; Cell Membrane; Diterpenes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Hydrogen-Ion Concentration; Linoleic Acid; Male; Membrane Fluidity; Membrane Potentials; Mice; Mice, Inbred C57BL; Oocytes; Pain; Rats; RNA, Complementary; TRPV Cation Channels; Xenopus laevis | 2007 |
Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death.
Topics: Anilides; Animals; Apoptosis; Capsaicin; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lung Neoplasms; Membrane Potentials; Mitochondria, Heart; Oxygen Consumption; Rats; TRPV Cation Channels | 2007 |
Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.
Topics: Activating Transcription Factor 3; Arachidonic Acids; Calcium; Capsaicin; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cinnamates; Cyclin D1; Cyclin G2; Cyclins; Diterpenes; Dithiothreitol; Endocannabinoids; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Epithelial Cells; Eukaryotic Initiation Factor-2; Gene Expression; Humans; Lung; Phosphorylation; Polyunsaturated Alkamides; Thapsigargin; Thiourea; Transcription Factor CHOP; Transfection; TRPV Cation Channels | 2007 |
Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.
Topics: Arachidonic Acids; Calcium; Calcium Signaling; Capsaicin; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dopamine; Endocannabinoids; Humans; Models, Biological; Neuroblastoma; Neurons; Norepinephrine; Polyunsaturated Alkamides; Recombinant Proteins; Synaptic Transmission; Transfection; TRPV Cation Channels; Up-Regulation | 2007 |
Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism.
Topics: Analgesia; Animals; Capsaicin; Carrageenan; Chemoreceptor Cells; Diterpenes; Electromagnetic Fields; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons, Afferent; Pain Measurement; Postural Balance | 2007 |
Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat.
Topics: Acute Disease; Animals; Capsaicin; Carrageenan; Diterpenes; Edema; Inflammation; Injections, Intraperitoneal; Male; Mass Spectrometry; Neurogenic Inflammation; Pituitary Adenylate Cyclase-Activating Polypeptide; Radioimmunoassay; Rats; Rats, Wistar; TRPV Cation Channels | 2007 |
Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol.
Topics: Acetaldehyde; Analgesics, Opioid; Calcium; Capsaicin; Cell Line; Central Nervous System Depressants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Drug Synergism; Estrenes; Ethanol; Humans; Ion Channel Gating; Kidney; Morphine; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Radioligand Assay; Sensory System Agents; Tritium; TRPV Cation Channels | 2008 |
Voltage is a partial activator of rat thermosensitive TRP channels.
Topics: Allosteric Regulation; Animals; Capsaicin; Cell Line; Diterpenes; Electric Stimulation; Hot Temperature; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Models, Chemical; Neurons, Afferent; Protein Kinase C; Rats; Sensory System Agents; TRPM Cation Channels; TRPV Cation Channels | 2007 |
Depletion of capsaicin-sensitive afferents prevents lamina-dependent increases in spinal N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Hot Temperature; Hyperalgesia; Ligation; Male; Perception; Phosphorylation; Posterior Horn Cells; Pressure; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Spinal Cord; Time Factors; TRPV Cation Channels; Up-Regulation | 2008 |
Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.
Topics: Action Potentials; Animals; Blood Pressure; Capsaicin; Cell Membrane; Cytosol; Diterpenes; Electrophysiology; Female; Kidney; Kidney Pelvis; Mechanoreceptors; Models, Biological; Neurokinin-1 Receptor Antagonists; Perfusion; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase | 2008 |
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.
Topics: Administration, Cutaneous; Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Edema; Electric Stimulation; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurogenic Inflammation; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Sciatic Nerve; Time Factors; TRPV Cation Channels | 2008 |
Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Catechols; Disease Models, Animal; Diterpenes; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Reaction Time; Skin; Substance P; Ubiquitin Thiolesterase | 2008 |
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Topics: Acetone; Administration, Cutaneous; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Capsaicin; Diterpenes; Drug Synergism; Ear; Edema; Ibuprofen; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Sensory Receptor Cells; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2007 |
Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice.
Topics: Animals; Animals, Genetically Modified; Calcium; Capsaicin; Diterpenes; Ganglia, Spinal; Gene Expression; Green Fluorescent Proteins; Male; Mice; Neurons; Pain Measurement; Phenotype; Protein Binding; Reaction Time; RNA Interference; RNA, Small Interfering; Spinal Cord; Spinal Cord Injuries; TRPV Cation Channels | 2008 |
Pharmacological effect of capsaicin on rat avoidance behaviours elicited by sine-wave electrical stimulation of different frequencies by Neurometer.
Topics: Animals; Avoidance Learning; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Subcutaneous; Male; Nerve Fibers; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Transcutaneous Electric Nerve Stimulation | 2008 |
Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory.
Topics: Anilides; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Memory; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Space Perception; Synaptic Transmission; TRPV Cation Channels | 2008 |
Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Capsaicin; Diterpenes; Interleukin-10; Male; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Reperfusion Injury; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2008 |
Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch.
Topics: Animals; Capsaicin; Diterpenes; Edema; Hindlimb; Hyperalgesia; Immunohistochemistry; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Spinal Cord | 2008 |
Red-hot chili peppers: a spicy new approach to preventing postoperative pain.
Topics: Capsaicin; Capsicum; Diterpenes; Humans; Pain, Postoperative; TRPV Cation Channels | 2008 |
A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cells, Cultured; Diterpenes; Neurosecretory Systems; Protein Kinase C; Rats; Sodium; Sodium Channel Blockers; TRPV Cation Channels; Veratridine | 2008 |
Human keratinocytes are vanilloid resistant.
Topics: Calcium; Capsaicin; Cell Death; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Drug Resistance; Humans; Keratinocytes; RNA, Messenger; Skin; TRPV Cation Channels | 2008 |
The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Capsaicin; Diterpenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Gene Expression; Glutamic Acid; Glycoproteins; In Vitro Techniques; Lectins; Male; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord; TRPV Cation Channels; Versicans; Vesicular Glutamate Transport Protein 2 | 2009 |
Clinical guidelines for overactive bladder.
Topics: Anti-Dyskinesia Agents; Antidepressive Agents; Behavior Control; Botulinum Toxins; Capsaicin; Cholinergic Antagonists; Diterpenes; Flavoxate; Humans; Parasympatholytics; Physical Therapy Modalities; Sensory System Agents; Urinary Bladder, Overactive | 2009 |
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels | 2009 |
Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation.
Topics: Animals; Capsaicin; Cell Line; Cell Respiration; Diterpenes; Encephalitis; Gliosis; Ion Channel Gating; Lanthanum; Membrane Potentials; Mice; Microglia; NADPH Oxidases; Organ Culture Techniques; Oxidative Stress; Reactive Oxygen Species; Respiratory Burst; Ruthenium Red; TRPV Cation Channels | 2009 |
Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes.
Topics: Capsaicin; Cell Line; Diterpenes; Gene Expression; Humans; Osmotic Pressure; Sensory System Agents; Synovial Membrane; Temperature; Transient Receptor Potential Channels; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2009 |
Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.
Topics: Analgesia; Animals; Capsaicin; Diterpenes; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; TRPV Cation Channels | 2009 |
Dynamic performance evaluation on the synergy of micturition in spinal cord-injured female rats under pharmacological effects.
Topics: Animals; Capsaicin; Disease Models, Animal; Diterpenes; Electromyography; Female; Models, Biological; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinal Cord Injuries; Urethra; Urinary Bladder; Urinary Bladder, Neurogenic; Urination | 2009 |
Effect of resiniferatoxin on glutamatergic spontaneous excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Topics: Animals; Capsaicin; Diterpenes; Glutamic Acid; In Vitro Techniques; Isothiocyanates; Male; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substantia Gelatinosa; Synaptic Transmission; TRPV Cation Channels | 2009 |
Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat.
Topics: Analysis of Variance; Animals; Capsaicin; Cold Temperature; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Female; Hot Temperature; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Thermosensing; TRPV Cation Channels | 2010 |
Olvanil: a non-pungent TRPV1 activator has anti-emetic properties in the ferret.
Topics: Animals; Antiemetics; Apomorphine; Arachidonic Acids; Behavior, Animal; Blood Pressure; Body Temperature; Capsaicin; Cisplatin; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Ferrets; Heart Rate; Male; TRPV Cation Channels; Vomiting | 2010 |
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.
Topics: Analgesics; Animals; Capsaicin; Diterpenes; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Pain Measurement; Plant Oils; Sensory System Agents; Stress, Mechanical; Thermosensing; Trigeminal Nerve; TRPV Cation Channels | 2010 |
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels | 2010 |
The TRPv1 receptor is a mediator of the exercise pressor reflex in rats.
Topics: Animals; Blood Pressure; Capsaicin; Diterpenes; Heart Rate; Hindlimb; Male; Muscle Contraction; Muscle, Skeletal; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Reflex; Ruthenium Red; TRPV Cation Channels | 2010 |
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.
Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Lipid Metabolism; Male; Neurons, Afferent; Pain; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sensory Receptor Cells; Solubility; TRPV Cation Channels; Urea | 2010 |
Effects of intravesical instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity.
Topics: Adenosine Triphosphate; Administration, Intravesical; Animals; Capsaicin; Diterpenes; Female; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neurons, Afferent; Neurotoxins; Rats; Rats, Sprague-Dawley; Sensory System Agents; Urinary Bladder | 2011 |
TRPV1, NK1 receptor and substance P immunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after systemic, low dose vanilloid administration.
Topics: Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Lumbar Vertebrae; Male; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Sacrum; Spinal Cord; Substance P; TRPV Cation Channels; Urinary Bladder | 2011 |
Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.
Topics: Animals; Bacterial Load; Capsaicin; Cecum; Cytokines; Disease Models, Animal; Diterpenes; Down-Regulation; Female; Flow Cytometry; Gene Expression; Ligation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Peritoneal Lavage; Peritoneum; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Survival Analysis; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2011 |
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies.
Topics: Amino Acid Sequence; Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Diterpenes; DNA Mutational Analysis; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Pain Management; Protein Conformation; Rats; TRPV Cation Channels | 2011 |
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Body Temperature Regulation; Brain; Camphanes; Capsaicin; Disease Models, Animal; Diterpenes; Endocannabinoids; Female; Hypothermia; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Lipopolysaccharides; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sulfonamides; Time Factors; TRPV Cation Channels | 2011 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Cromolyn Sodium; Disease Models, Animal; Diterpenes; Edema; Gabexate; Histamine; Male; Mast Cells; Methysergide; Pain; Promethazine; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Serotonin; Serotonin Antagonists; Tritium; TRPV Cation Channels; Uric Acid | 2011 |
Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators.
Topics: Animals; Blood Glucose; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Diterpenes; Glucose Tolerance Test; Hyperalgesia; Hyperglycemia; Inflammation Mediators; Injections, Intraperitoneal; Injections, Spinal; Insulin; Microglia; Pain; Posterior Horn Cells; Rats; Streptozocin; TRPV Cation Channels | 2011 |
Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Blotting, Western; Calcineurin; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dietary Fats; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Immunohistochemistry; Lipid Metabolism; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polymerase Chain Reaction; Receptors, LDL; RNA, Messenger; Time Factors; TRPV Cation Channels; Tumor Suppressor Proteins | 2011 |
Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts.
Topics: Airway Remodeling; Bronchi; Calcium Signaling; Capsaicin; Cells, Cultured; Diterpenes; Fibroblasts; Gene Expression; Humans; Inflammation Mediators; Interleukin-1alpha; Lipopolysaccharides; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons.
Topics: Animals; CA1 Region, Hippocampal; Calcineurin; Calcineurin Inhibitors; Capsaicin; Cyclosporine; Diterpenes; Excitatory Postsynaptic Potentials; In Vitro Techniques; Interneurons; Long-Term Synaptic Depression; Male; Rats; Rats, Sprague-Dawley; Tacrolimus; TRPV Cation Channels | 2012 |
Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Bradykinin; Capsaicin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diterpenes; Heart; Kidney; Lidocaine; Losartan; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reflex; Sympathetic Nervous System; TRPV Cation Channels | 2012 |
TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Cannabinoid Receptor Antagonists; Capsaicin; Cyclic AMP; Diterpenes; Endocannabinoids; Glycerides; Hydrogen-Ion Concentration; Odontoblasts; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Sodium-Calcium Exchanger; Thiourea; TRPV Cation Channels | 2012 |
Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Calcium; Capsaicin; Chromatography, High Pressure Liquid; Diterpenes; Edema; Freund's Adjuvant; Hot Temperature; Male; Mice; Nociceptors; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Stigmasterol; Tissue Distribution; TRPV Cation Channels; Vernonia | 2012 |
Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension.
Topics: Adipose Tissue, White; Angiotensin II; Animals; Blood Pressure; Capsaicin; Diet, High-Fat; Diterpenes; Enzyme-Linked Immunosorbent Assay; Hypertension; Immunohistochemistry; Lidocaine; Male; Norepinephrine; Obesity; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reflex; Renin; Sensory System Agents; Sympathetic Nervous System | 2012 |
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.
Topics: Acrylamides; Animals; Biotinylation; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cell Line; Chlorides; Colforsin; Colon; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Electric Conductivity; Epithelial Cells; Humans; Immunohistochemistry; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Time Factors; TRPV Cation Channels | 2013 |
Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis.
Topics: Acute Disease; Animals; Capsaicin; Central Nervous System Depressants; Diterpenes; Duodenum; Edema; Ethanol; Fluorescent Antibody Technique; Ganglia, Spinal; Male; Muscle Contraction; Pancreas; Pancreatitis; Patch-Clamp Techniques; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Sensory Receptor Cells; Splanchnic Nerves; Stomach; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2013 |
Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.
Topics: Action Potentials; Animals; Antipruritics; Benzaldehydes; Benzylamines; Capsaicin; Curcumin; Diterpenes; Eugenol; Female; Guaiacol; Male; Procaine; Ranidae; Sciatic Nerve; Structure-Activity Relationship; TRPV Cation Channels; Vanillic Acid | 2013 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Morphine; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Opioid, mu; Sensory Receptor Cells; Substance Withdrawal Syndrome; Tritium; TRPV Cation Channels | 2013 |
Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dogs; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; MCF-7 Cells; TRPV Cation Channels | 2015 |
TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.
Topics: Amiloride; Anilides; Animals; Capsaicin; Chorda Tympani Nerve; Cinnamates; Diterpenes; Mice; Mice, Knockout; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sodium Chloride; Taste; TRPM Cation Channels; TRPV Cation Channels | 2013 |
"Chemical-pain sensor" based on nanovesicle-carbon nanotube hybrid structures.
Topics: Animals; Biosensing Techniques; Capsaicin; Cloning, Molecular; Diterpenes; HEK293 Cells; Hot Temperature; Humans; Immobilized Proteins; Limit of Detection; Nanostructures; Nanotubes, Carbon; Pain; Rats; Sensitivity and Specificity; Sensory System Agents; TRPV Cation Channels | 2013 |
Additive antiemetic efficacy of low-doses of the cannabinoid CB(1/2) receptor agonist Δ(9)-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva).
Topics: Animals; Antiemetics; Cannabinoid Receptor Agonists; Capsaicin; Cisplatin; Diterpenes; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Female; Male; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Ruthenium Red; Shrews; TRPV Cation Channels; Vomiting | 2014 |
Peripheral afferent mechanisms underlying acupuncture inhibition of cocaine behavioral effects in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Cocaine-Related Disorders; Diterpenes; Electric Stimulation; Locomotion; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Rats; Rats, Sprague-Dawley; Sensory System Agents; Ulnar Nerve | 2013 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Nociception; Rats; Rats, Wistar; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hindlimb; Hyperalgesia; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nociceptors; Pain Threshold; Peroxidase; Reactive Oxygen Species; Sensory System Agents; Somatostatin; Tarsus, Animal; TRPV Cation Channels; X-Ray Microtomography | 2015 |
Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations.
Topics: Animals; Benzoxazoles; Biological Transport; Capsaicin; Cations; Diterpenes; Fluorescent Dyes; HEK293 Cells; Humans; Ion Channel Gating; Meglumine; Mice; Models, Molecular; Mutation, Missense; Permeability; Protein Structure, Secondary; Protein Structure, Tertiary; Quinolinium Compounds; Rats; TRPV Cation Channels | 2015 |
Capsaicin, resiniferatoxin and botulinum toxin-A – a trip down memory lane.
Topics: Botulinum Toxins, Type A; Capsaicin; Diterpenes; Humans; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive | 2015 |
Vanilloids selectively sensitize thermal glutamate release from TRPV1 expressing solitary tract afferents.
Topics: Animals; Capsaicin; Diterpenes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels | 2016 |
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
Topics: Acetanilides; Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Diterpenes; Male; Mibefradil; Mice; Pruritus; Purines; Receptors, Opioid; RNA Interference; Sensory Receptor Cells; Sulfides; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni.
Topics: Animals; Capsaicin; Diterpenes; DNA, Helminth; Female; Gene Knockdown Techniques; Locomotion; Mice; Molecular Sequence Data; Schistosoma mansoni; Sequence Analysis, DNA; Transient Receptor Potential Channels | 2015 |
Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.
Topics: Amino Acids; Binding Sites; Capsaicin; Cryoelectron Microscopy; Diterpenes; Electricity; Ion Channel Gating; Ligands; Molecular Docking Simulation; Mutagenesis; Mutant Proteins; Static Electricity; TRPV Cation Channels; Water | 2016 |
Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons.
Topics: Animals; Apoptosis; Breast; Breast Neoplasms; Capsaicin; Cells, Cultured; Diterpenes; Epithelial Cells; Female; Humans; Male; Neoplasm Proteins; Prostate; Prostatic Neoplasms; Rats; Rats, Wistar; Recombinant Proteins; Sensory Receptor Cells; Trigeminal Ganglion; TRPV Cation Channels | 2016 |
TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation.
Topics: Animals; Body Temperature Regulation; Brain; Capsaicin; Diterpenes; Lipopolysaccharides; Mice; Mice, Knockout; Signal Transduction; STAT3 Transcription Factor; TRPV Cation Channels | 2016 |
Rational design and validation of a vanilloid-sensitive TRPV2 ion channel.
Topics: Binding Sites; Capsaicin; Diterpenes; Humans; Ligands; Molecular Docking Simulation; Point Mutation; Protein Domains; TRPV Cation Channels | 2016 |
Competitive inhibition of TRPV1-calmodulin interaction by vanilloids.
Topics: Binding Sites; Calmodulin; Capsaicin; Diterpenes; Humans; Pain; Protein Binding; Protein Conformation; Protein Interaction Maps; Sensory Receptor Cells; TRPV Cation Channels | 2016 |
Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cell Line; Cells, Cultured; Dipeptides; Diterpenes; Female; Glyburide; Hydrogen Sulfide; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Potassium Chloride; Quinazolines; Receptors, Neurokinin-1; Sensory Receptor Cells; Substance P; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; Vasodilation | 2016 |
Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.
Topics: Amino Acids; Calcium; Capsaicin; Catechols; Diterpenes; DNA Mutational Analysis; Fatty Alcohols; Humans; Kinetics; Ligands; Models, Molecular; Molecular Docking Simulation; Mutant Proteins; Mutation; Point Mutation; Protons; Reproducibility of Results; Sequence Homology, Amino Acid; Structure-Activity Relationship; TRPV Cation Channels | 2016 |
Antinociceptive activity and mechanism of action of hydroalcoholic extract and dichloromethane fraction of Amphilophium crucigerum seeds in mice.
Topics: Analgesics; Animals; Bignoniaceae; Binding, Competitive; Calcium Signaling; Capsaicin; Chronic Pain; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Ethanol; Male; Methylene Chloride; Mice; Neuralgia; Nociception; Nociceptive Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plants, Medicinal; Protein Binding; Seeds; Signal Transduction; Solvents; Spinal Cord; Synaptosomes; TRPV Cation Channels | 2017 |
Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse.
Topics: Animals; Capsaicin; Cold Temperature; Disease Models, Animal; Diterpenes; Hot Temperature; Hyperalgesia; Male; Mice; Nociception; Nociceptive Pain; Nociceptors; Restraint, Physical; Stress, Psychological | 2017 |
Role of peripheral and central TRPV1 receptors in facial heat hyperalgesia in streptozotocin-induced diabetic rats.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Diterpenes; Face; Facial Pain; Hot Temperature; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Trigeminal Ganglion; TRPV Cation Channels | 2017 |
Human podocytes express functional thermosensitive TRPV channels.
Topics: Calcium; Calcium Signaling; Cannabidiol; Capsaicin; Cell Line; Diterpenes; Glomerular Filtration Barrier; Humans; Patch-Clamp Techniques; Podocytes; RNA, Messenger; TRPV Cation Channels | 2017 |
Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Drug Resistance; Facial Nerve Diseases; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Nerve Tissue Proteins; Neurons, Afferent; Neurotoxins; Nitric Oxide Donors; Nitroglycerin; Organ Specificity; Peripheral Nervous System Diseases; Sensory System Agents; TRPV Cation Channels | 2018 |
Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate.
Topics: Adipose Tissue, Brown; Animals; Arterial Pressure; Capsaicin; Cardiovascular System; Diterpenes; Heart Rate; Male; Rats, Sprague-Dawley; Signal Transduction; Solitary Nucleus; Thermogenesis; TRPV Cation Channels; Vagus Nerve | 2018 |
Selective ablation of TRPV1 by intrathecal injection of resiniferatoxin in rats increases renal sympathoexcitatory responses and salt sensitivity.
Topics: Animals; Blood Pressure; Capsaicin; Diterpenes; Glutamate Decarboxylase; Injections, Spinal; Kidney; Male; Rats; Rats, Wistar; Receptors, GABA-A; Sodium Chloride, Dietary; Sympathetic Nervous System; TRPV Cation Channels; Tyrosine 3-Monooxygenase | 2018 |
TRPV1 mediates capsaicin-stimulated metabolic activity but not cell death or inhibition of interleukin-1β release in human THP-1 monocytes.
Topics: Capsaicin; Cell Death; Cell Line; Diterpenes; Humans; Interleukin-1beta; Interleukin-6; Monocytes; THP-1 Cells; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2018 |
Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.
Topics: Animals; Ankle Joint; Antibodies; Arthritis, Experimental; Body Weight; Capsaicin; Disease Models, Animal; Diterpenes; Edema; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Severity of Illness Index; X-Ray Microtomography | 2018 |
Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice.
Topics: Analgesics; Animals; Calcium; Capsaicin; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Flavonoids; Inflammation; Male; Mice; Neuralgia; Pain; Pain Measurement; Spinal Cord; Synaptosomes; Toxicity Tests; TRPV Cation Channels | 2019 |
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.
Topics: Animals; Ankle; Arthritis, Rheumatoid; Capsaicin; Cartilage; Disease Models, Animal; Diterpenes; Female; Hindlimb; Mice; Mice, Inbred BALB C; Neurotoxins; Peptides; Proteoglycans; Reactive Oxygen Species; Sensory System Agents; Sensory Thresholds; Severity of Illness Index; Spine | 2018 |
Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Diterpenes; Ganglia, Spinal; HEK293 Cells; Humans; Neurons; Rats, Sprague-Dawley; TRPV Cation Channels | 2019 |
Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Capsaicin; Diterpenes; Male; Mice; Mice, Inbred BALB C; Neurogenic Inflammation; Neuropeptides; Reactive Oxygen Species; Sensory System Agents | 2021 |
Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.
Topics: Animals; Astrocytes; Capsaicin; Diterpenes; Ganglia, Spinal; Hyperalgesia; Intercellular Signaling Peptides and Proteins; Male; Neuralgia; Neurons; Rats, Sprague-Dawley; Spinal Cord | 2021 |
Evaluation of a polymer-coated nanoparticle cream formulation of resiniferatoxin for the treatment of painful diabetic peripheral neuropathy.
Topics: Analgesics; Animals; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diterpenes; Pain; Rats; Swine; Swine, Miniature; TRPV Cation Channels | 2023 |