capsaicin and piperine

capsaicin has been researched along with piperine in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (10.45)	18.7374
1990's	11 (16.42)	18.2507
2000's	15 (22.39)	29.6817
2010's	28 (41.79)	24.3611
2020's	6 (8.96)	2.80

Authors

Authors	Studies
Nilius, B; Owsianik, G; Talavera, K; Voets, T	1
Correa, EA; Echeverri, F; Högestätt, ED; Sterner, O; Zygmunt, PM	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Doble, M; Manju, SL; Sinha, S	1
Maggi, CA; Meli, A; Patacchini, R	1
Jin, JG; Lu, YF; Nakayama, S; Takaki, M	1
Szolcsànyi, J	2
Goto, K; Ishikawa, T; Miyauchi, T; Saito, A; Sugishita, Y	1
Lawless, HT; Stevens, DA	3
Iwai, K; Kawada, T; Sakabe, S; Watanabe, T; Yamamoto, M	1
Micevych, PE; Szolcsanyi, J; Yaksh, TL	1
Bennett, KL; Clark, MG; Colquhoun, EQ; Dora, KA; Eldershaw, TP	1
Matui, T; Yoshii, K	1
Liu, L; Simon, SA	1
Green, BG	1
Green, BG; Rentmeister-Bryant, H	1
Arguelles, JH; Baumann, TK; Martenson, ME	1
Carstens, E; Handwerker, HO; Kuenzler, N	1
Farkas, B; Helyes, ZS; Németh, J; Oroszi, G; Pintér, E; Szolcsányi, J; Thán, M	1
Capasso, F; Capasso, R; Di Carlo, G; Izzo, AA; Mascolo, N; Pinto, L	1
Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Nocerino, E; Pinto, A; Sautebin, L	1
Naidu, KA; Thippeswamy, NB	1
Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, A; Russo, A; Sautebin, L	1
Green, BG; Hayes, JE	1
Gunthorpe, MJ; McNamara, FN; Randall, A	1
Boudaka, A; Kobayashi, H; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J	1
De Ridder, D; Gevaert, T; Hutchings, G; Nilius, B; Vandepitte, J; Vriens, J	1
Matsuda, H; Nagatomo, A; Ochi, M; Yoshikawa, M	1
Affeltranger, MA; Balaban, CD; McBurney, DH	1
Srinivasan, K; Suresh, D	3
Boudaka, A; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J	1
Naidu, KA; Raghavendra, RH	1
Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR	1
Prakash, UN; Srinivasan, K	4
Azuma, M; Kang, KS; Matsuda, K; Sakashita, A; Shioda, S; Yahashi, S	1
Beattie, RE; Knopp, K; Liu, B; Sher, E; Ursu, D	1
Fujita, T; Jiang, CY; Kumamoto, E; Mizuta, K; Piao, LH; Yang, L; Yue, HY	1
Castellaneta, E; Cava, E; Ceccarelli, P; Claudia, S; Donini, LM; Edda, C; Emanuela, C; Faliva, M; Fioravanti, M; Klersy, C; Luciano, S; Maddalena, P; Opizzi, A; Paola, C; Paolini, M; Perna, S; Rondanelli, M; Savina, C; Scavone, L; Solerte, SB	1
Claudia, S; Donini, LM; Edda, C; Emanuela, C; Faliva, M; Fioravanti, M; Klersy, C; Luciano, S; Maddalena, P; Opizzi, A; Paola, C; Perna, S; Rondanelli, M; Solerte, SB	1
Srinivasan, K	1
Alvarez-Berdugo, D; Clavé, P; Jiménez, M; Rofes, L	1
Cho, YM; Kiriyama, Y; Nishikawa, A; Ogawa, K; Shi, L; Takasu, S; Tatematsu, M; Toyoda, T; Tsukamoto, T	1
Bartho, L; Bencsik, T; Sandor, Z	1
Khan, M; Ma, T; Maryam, A; Mehmood, T; Zhang, Y	1
Hayes, JE; McGeary, JE; Nolden, AA	1
Li, HB; Li, S; Li, Y; Xu, DP; Zheng, J; Zhou, Y	1
Lim, LY; Shamsi, S; Tan, RS; Tan, ZJ; Tran, H	1
Kim, TH; Shin, BS; Shin, S; Yoo, SD	1
Krstin, S; Li, H; Wang, S; Wink, M	1
Carneiro de Freitas, JC; Macedo Rondon, FC; Maia de Morais, S; Pereira Mendes, FN; Pinto Vieira, ÍG; Vieira-Araújo, FM	1
Ahmad, I; Baig, MH; Imran, M; Kausar, MA; Saeed, M; Shahid, S	1
Dong, Y; Tian, Y; Vu, S; Yang, F; Yarov-Yarovoy, V; Yin, Y; Zheng, J	1
Gerber, W; Hamman, J; Kotzé, A; Steyn, D; Svitina, H; Weldon, C	1
Gaafar, AY; Istiqomah, I; Kawato, Y; Nakai, T; Ninomiya, K; Yamashita, H; Younes, A	1
Buitimea-Cantúa, GV; Buitimea-Cantúa, NE; Hernández-Morales, A; Magaña-Barajas, E; Molina-Torres, J; Rocha-Pizaña, MDR	1
Almeida, PM; Dias, MS; Junior, EPV; Martins, FA; Peron, AP; Santos, BCD	1
Ambedkar, R; Baskaran, V; Hanumanthappa, M; Lakshminarayana, R; Perumal, MK; Shilpa, S; Shwetha, HJ	1
Mao, Y; Mei, X; Shi, W; Song, J; Xie, Y; Xu, Z	1
Alvarez-Berdugo, D; Clavé, P; Ortega, O; Rofes, L; Tomsen, N	1

Reviews

5 review(s) available for capsaicin and piperine

Article	Year
Sensing with TRP channels. Nature chemical biology, 2005, Volume: 1, Issue:2 Topics: Animals; Humans; Ligands; Models, Biological; Phylogeny; Temperature; Transient Receptor Potential Channels	2005
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. Bioorganic & medicinal chemistry, 2019, 09-01, Volume: 27, Issue:17 Topics: Animals; Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Drug Design; Humans; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Molecular Structure; Structure-Activity Relationship	2019
Antioxidant potential of spices and their active constituents. Critical reviews in food science and nutrition, 2014, Volume: 54, Issue:3 Topics: Alkaloids; Anti-Inflammatory Agents; Antimutagenic Agents; Antioxidants; Benzodioxoles; Capsaicin; Cardiotonic Agents; Catechols; Curcumin; Eugenol; Fatty Alcohols; Garlic; Humans; Neoplasms; Onions; Oxidative Stress; Phenols; Piperidines; Polyunsaturated Alkamides; Spices; Trigonella	2014
Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:16 Topics: Abietanes; Alkaloids; Allyl Compounds; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzodioxoles; beta Carotene; Biflavonoids; Capsaicin; Catechin; Catechols; Curcumin; Dietary Supplements; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fatty Alcohols; Furocoumarins; Humans; Indoles; Limonins; Neoplasms; Phytotherapy; Piperidines; Polyunsaturated Alkamides; Proanthocyanidins; Quercetin; Resveratrol; Stilbenes; Sulfides; Tea; Triterpenes; Xanthophylls	2015
Spices for Prevention and Treatment of Cancers. Nutrients, 2016, Aug-12, Volume: 8, Issue:8 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Benzodioxoles; Benzoquinones; Capsaicin; Capsicum; Cell Proliferation; Crocus; Curcuma; Curcumin; Garlic; Humans; Neoplasms; Nigella sativa; Phytotherapy; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Spices; Zingiber officinale	2016

Trials

4 trial(s) available for capsaicin and piperine

Article	Year
Rapid recovery from capsaicin desensitization during recurrent stimulation. Pain, 1996, Volume: 68, Issue:2-3 Topics: Administration, Oral; Adult; Alkaloids; Analysis of Variance; Benzodioxoles; Capsaicin; Citric Acid; Depression, Chemical; Dose-Response Relationship, Drug; Female; Guaiacol; Humans; Irritants; Logistic Models; Male; Piperidines; Polyunsaturated Alkamides; Reference Values; Stimulation, Chemical; Time Factors; Tongue	1996
Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects. Endocrine, 2013, Volume: 44, Issue:2 Topics: Adipokines; Adult; Alkaloids; Benzodioxoles; Capsaicin; Carnitine; Catechin; Diet, Reducing; Dietary Supplements; Double-Blind Method; Female; Humans; Inflammation Mediators; Insulin Resistance; Male; Middle Aged; Overweight; Piperidines; Polyunsaturated Alkamides; Time Factors; Weight Loss; Young Adult	2013
Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. Journal of the American College of Nutrition, 2013, Volume: 32, Issue:1 Topics: Adult; Alkaloids; Area Under Curve; Basal Metabolism; Benzodioxoles; Capsaicin; Carnitine; Catechin; Dietary Supplements; Double-Blind Method; Fatty Acids, Nonesterified; Female; Glucagon-Like Peptide 1; Glycerol; Humans; Male; Middle Aged; Obesity; Phytotherapy; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Satiation; Satiety Response	2013
Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata. Journal of cosmetic dermatology, 2022, Volume: 21, Issue:10 Topics: Administration, Topical; Alopecia; Alopecia Areata; Capsaicin; Curcumin; Humans; Minoxidil	2022

Other Studies

58 other study(ies) available for capsaicin and piperine

Article	Year
In vitro TRPV1 activity of piperine derived amides. Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9 Topics: Alkaloids; Amides; Benzodioxoles; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Spectrometry, Fluorescence; TRPV Cation Channels	2010
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:1 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Curcumin; Eugenol; In Vitro Techniques; Isothiocyanates; Male; Muscle Contraction; Mustard Plant; Nerve Endings; Neurons, Afferent; Piperidines; Plant Extracts; Plant Oils; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Ruthenium Red; Tetrodotoxin; Thiocyanates	1990
Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with capsaicin. European journal of pharmacology, 1990, Sep-04, Volume: 186, Issue:1 Topics: Alkaloids; Animals; Anticonvulsants; Atropine; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Endings; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Ruthenium Red; Substance P; Tachyphylaxis; Tetrodotoxin	1990
Effect of capsaicin, resiniferatoxin and piperine on ethanol-induced gastric ulcer of the rat. Acta physiologica Hungarica, 1990, Volume: 75 Suppl Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Diterpenes; Ethanol; Female; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stomach Ulcer	1990
Involvement of calcitonin gene-related peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:2 Topics: Alkaloids; Animals; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Neuropeptides; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tachyphylaxis	1989
Responses by humans to oral chemical irritants as a function of locus of stimulation. Perception & psychophysics, 1988, Volume: 43, Issue:1 Topics: Adolescent; Adult; Alkaloids; Benzodioxoles; Capsaicin; Female; Humans; Male; Mouth; Piperidines; Polyunsaturated Alkamides; Sensation; Time Factors; Tongue	1988
Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 188, Issue:2 Topics: Adrenal Medulla; Alkaloids; Animals; Benzodioxoles; Capsaicin; Catecholamines; Condiments; Epinephrine; Guaiacol; Intestinal Absorption; Kinetics; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains	1988
Enhancement of responses to sequential presentation of oral chemical irritants. Physiology & behavior, 1987, Volume: 39, Issue:1 Topics: Alkaloids; Benzodioxoles; Capsaicin; Drug Administration Schedule; Drug Synergism; Humans; Irritants; Mouth; Piperidines; Polyunsaturated Alkamides	1987
Putting out the fire: effects of tastants on oral chemical irritation. Perception & psychophysics, 1986, Volume: 39, Issue:5 Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Citrates; Citric Acid; Humans; Piperidines; Polyunsaturated Alkamides; Quinine; Sodium Chloride; Sucrose; Taste; Water	1986
Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats. Neuroscience, 1983, Volume: 8, Issue:1 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Cholecystokinin; Enkephalin, Methionine; Fatty Acids, Unsaturated; Ganglia, Spinal; Kainic Acid; Male; Microscopy, Fluorescence; Nociceptors; Peptides; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Somatostatin; Substance P	1983
Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea. Neuroscience letters, 1983, Nov-21, Volume: 42, Issue:1 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Denervation; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Muscle, Smooth; Neuromuscular Junction; Pain; Piperidines; Polyunsaturated Alkamides; Tetrodotoxin; Trachea	1983
Resiniferatoxin and piperine: capsaicin-like stimulators of oxygen uptake in the perfused rat hindlimb. Life sciences, 1994, Volume: 55, Issue:5 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Hindlimb; Male; Nitroglycerin; Oxygen Consumption; Perfusion; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar	1994
Taste responses of bullfrog to pungent stimuli. Brain research, 1994, Feb-21, Volume: 637, Issue:1-2 Topics: Adaptation, Physiological; Alkaloids; Animals; Benzodioxoles; Capsaicin; Chemoreceptor Cells; Electrophysiology; Glossopharyngeal Nerve; In Vitro Techniques; Isothiocyanates; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Rana catesbeiana; Regional Blood Flow; Sensory Thresholds; Stimulation, Chemical; Taste; Tongue	1994
Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. Journal of neurophysiology, 1996, Volume: 76, Issue:3 Topics: Alkaloids; Animals; Benzodioxoles; Biotransformation; Calcium; Capsaicin; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Guaiacol; Ion Channels; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Tachyphylaxis; Trigeminal Ganglion	1996
Perceived irritation during ingestion of capsaicin or piperine: comparison of trigeminal and non-trigeminal areas. Chemical senses, 1997, Volume: 22, Issue:3 Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Chemoreceptor Cells; Female; Glossopharyngeal Nerve; Humans; Irritants; Male; Mouth; Perception; Pharynx; Piperidines; Polyunsaturated Alkamides; Tongue; Trigeminal Nerve	1997
Enhancement of rat trigeminal ganglion neuron responses to piperine in a low-pH environment and block by capsazepine. Brain research, 1997, Jun-27, Volume: 761, Issue:1 Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Binding, Competitive; Capsaicin; Female; Hydrogen-Ion Concentration; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Protons; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion	1997
Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. Journal of neurophysiology, 1998, Volume: 80, Issue:2 Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Capsaicin; Conjunctiva; Cornea; Dose-Response Relationship, Drug; Electrophysiology; Ethanol; Ganglionic Stimulants; Histamine; Irritants; Male; Mouth Mucosa; Mustard Plant; Neurons; Nicotine; Piperidines; Plant Extracts; Plant Oils; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reaction Time; Serotonin; Sodium Chloride; Solvents; Stimulation, Chemical; Tachyphylaxis; Tongue; Trigeminal Nuclei	1998
Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release. Neurobiology (Budapest, Hungary), 1999, Volume: 7, Issue:4 Topics: Alkaloids; Animals; Benzodioxoles; Calibration; Capsaicin; Diterpenes; Electric Stimulation; Enzyme Inhibitors; Female; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Trachea	1999
Effect of vanilloid drugs on gastrointestinal transit in mice. British journal of pharmacology, 2001, Volume: 132, Issue:7 Topics: Alkaloids; Animals; Arachidonic Acids; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Transit; Hexamethonium; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Yohimbine	2001
Relaxant effect of capsazepine in the isolated rat ileum. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 365, Issue:3 Topics: Alkaloids; Animals; Benzodioxoles; Calcium Channels, L-Type; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug	2002
Inhibition of human low density lipoprotein oxidation by active principles from spices. Molecular and cellular biochemistry, 2002, Volume: 229, Issue:1-2 Topics: Alkaloids; Allyl Compounds; Ascorbic Acid; Benzodioxoles; Butylated Hydroxyanisole; Capsaicin; Curcumin; Eugenol; Humans; In Vitro Techniques; Lipoproteins, LDL; Oxidation-Reduction; Piperidines; Polyunsaturated Alkamides; Quercetin; Spices; Sulfides	2002
Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice. Life sciences, 2002, Sep-27, Volume: 71, Issue:19 Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Castor Oil; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Intestinal Secretions; Intestine, Small; Male; Mice; Mice, Inbred ICR; Organ Size; Piperidines; Polyunsaturated Alkamides	2002
Individual differences in perception of bitterness from capsaicin, piperine and zingerone. Chemical senses, 2004, Volume: 29, Issue:1 Topics: Adolescent; Adult; Alkaloids; Benzodioxoles; Capsaicin; Female; Guaiacol; Humans; Male; Middle Aged; Perception; Piperidines; Polyunsaturated Alkamides; Receptors, Cell Surface; Taste; Taste Buds	2004
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). British journal of pharmacology, 2005, Volume: 144, Issue:6 Topics: Alkaloids; Benzodioxoles; Capsaicin; Cell Line; Humans; Hydrogen-Ion Concentration; Patch-Clamp Techniques; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Receptors, Drug; Ruthenium Red; Structure-Activity Relationship	2005
Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus. European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3 Topics: Alkaloids; Anilides; Animals; Benzodioxoles; Capsaicin; Cinnamates; Cricetinae; Enzyme Inhibitors; Esophagus; Female; Male; Mesocricetus; Mice; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Tachykinin; Species Specificity; TRPV Cation Channels; Tryptophan; Vagus Nerve	2007
TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist. Neurourology and urodynamics, 2007, Volume: 26, Issue:3 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Female; Indicators and Reagents; Mechanotransduction, Cellular; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pressure; Rats; Rats, Wistar; Ruthenium Red; Stress, Mechanical; TRPV Cation Channels; Urinary Bladder	2007
Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats. European journal of pharmacology, 2007, Apr-30, Volume: 561, Issue:1-3 Topics: Alkaloids; Ammonia; Animals; Armoracia; Aspirin; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Ethanol; Food Preservatives; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Isothiocyanates; Male; NG-Nitroarginine Methyl Ester; Omeprazole; Piperidines; Polyunsaturated Alkamides; Prostaglandins; Rats; Rats, Sprague-Dawley; Ruthenium Red; Structure-Activity Relationship	2007
Temporal interactions between oral irritants: piperine, zingerone, and capsaicin. Chemical senses, 2007, Volume: 32, Issue:5 Topics: Administration, Oral; Alkaloids; Benzodioxoles; Capsaicin; Guaiacol; Humans; Irritants; Piperidines; Polyunsaturated Alkamides	2007
Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro. Canadian journal of physiology and pharmacology, 2006, Volume: 84, Issue:12 Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Capsaicin; Carrier Proteins; Curcumin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Heme-Binding Proteins; Hemeproteins; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar	2006
Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:8 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Curcumin; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Micelles; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spices	2007
Galanin modulates vagally induced contractions in the mouse oesophagus. Neurogastroenterology and motility, 2009, Volume: 21, Issue:2 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Esophagus; Female; Galanin; Indoles; Male; Mice; Muscle Contraction; NG-Nitroarginine Methyl Ester; Phenanthrolines; Piperidines; Polyunsaturated Alkamides; Receptors, Galanin; Sensory System Agents; Substance P; Vagus Nerve	2009
Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins, leukotrienes, and essential fatty acids, 2009, Volume: 81, Issue:1 Topics: Acrolein; Adenosine Diphosphate; Alkaloids; Allyl Compounds; Arachidonic Acid; Benzodioxoles; Calcimycin; Capsaicin; Collagen Type III; Curcumin; Eugenol; Humans; Malondialdehyde; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polyunsaturated Alkamides; Quercetin; Spices; Sulfides; Thromboxanes	2009
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels	2010
Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats. The British journal of nutrition, 2010, Volume: 104, Issue:1 Topics: Alkaloids; Animals; Benzodioxoles; Biological Availability; Capsaicin; Capsicum; Cell Membrane; Cholesterol; Diet; Enterocytes; Enzymes; Gastrointestinal Agents; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lipid Metabolism; Magnoliopsida; Male; Membrane Fluidity; Microscopy, Electron, Scanning; Microvilli; Phospholipids; Piper nigrum; Piperidines; Plant Preparations; Polyunsaturated Alkamides; Protein Conformation; Rats; Rats, Wistar; Spices; Zingiber officinale	2010
Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2010, Volume: 35, Issue:2 Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Capsaicin; Capsicum; Catalase; Cytoprotection; Diet; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Gastrointestinal Diseases; Glutathione Reductase; Glutathione Transferase; Glycoproteins; Intestinal Mucosa; Male; Mucus; Oxidative Stress; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spices; Superoxide Dismutase; Zingiber officinale	2010
Effect of intraperitoneal injection of curcumin on food intake in a goldfish model. Journal of molecular neuroscience : MN, 2011, Volume: 45, Issue:2 Topics: Alkaloids; Animals; Appetite Depressants; Appetite Regulation; Benzodioxoles; Capsaicin; Corticotropin-Releasing Hormone; Curcumin; Eating; Enzyme Inhibitors; Feeding Behavior; Goldfish; Hormone Antagonists; Humans; Injections, Intraperitoneal; Molecular Structure; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Receptors, Corticotropin-Releasing Hormone; Sensory System Agents; Triterpenes; Ursolic Acid	2011
Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. The Indian journal of medical research, 2010, Volume: 131 Topics: Administration, Oral; Alkaloids; Animals; Benzodioxoles; Biological Availability; Capsaicin; Chromatography, High Pressure Liquid; Curcumin; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Tissue Distribution	2010
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity. European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3 Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Lipid Metabolism; Male; Neurons, Afferent; Pain; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sensory Receptor Cells; Solubility; TRPV Cation Channels; Urea	2010
TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons. Biochemical and biophysical research communications, 2011, Jul-15, Volume: 410, Issue:4 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Excitatory Amino Acid Agents; Glutamates; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission; TRPV Cation Channels	2011
Fat digestion and absorption in spice-pretreated rats. Journal of the science of food and agriculture, 2012, Volume: 92, Issue:3 Topics: Adiposity; Alkaloids; Animals; Benzodioxoles; Bile; Bile Acids and Salts; Capsaicin; Curcumin; Diet, High-Fat; Dietary Fats; Digestion; Hydrolases; India; Intestinal Absorption; Lipid Metabolism; Liver; Male; Pancreas; Piperidines; Polyunsaturated Alkamides; Rats, Wistar; Rhizome; Spices; Up-Regulation; Zingiber officinale	2012
Enhanced intestinal uptake of iron, zinc and calcium in rats fed pungent spice principles--piperine, capsaicin and ginger (Zingiber officinale). Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2013, Volume: 27, Issue:3 Topics: Alkaloids; Animals; Benzodioxoles; Calcium; Capsaicin; Intestinal Absorption; Intestinal Mucosa; Intestines; Iron; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Zinc; Zingiber officinale	2013
Pharmacodynamics of TRPV1 agonists in a bioassay using human PC-3 cells. TheScientificWorldJournal, 2014, Volume: 2014 Topics: Alkaloids; Apoptosis; Benzodioxoles; Biological Assay; Capsaicin; Cell Line, Tumor; Cell Survival; Humans; Male; Metabolic Clearance Rate; Piperidines; Polyunsaturated Alkamides; Prostatic Neoplasms; TRPV Cation Channels	2014
Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils. Helicobacter, 2016, Volume: 21, Issue:2 Topics: Alkaloids; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Benzodioxoles; Capsaicin; Chemoprevention; Colony Count, Microbial; Diet Therapy; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Piperidines; Polyunsaturated Alkamides; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Stomach	2016
High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs. Pharmacology, 2015, Volume: 96, Issue:1-2 Topics: Acetanilides; Alkaloids; Animals; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Piperidines; Polyunsaturated Alkamides; Purines; Pyrazines; Pyridines; Trachea; TRPV Cation Channels; Urinary Bladder	2015
Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiology & behavior, 2016, Mar-15, Volume: 156 Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Ethanol; Female; Genetic Variation; Genotype; Humans; Male; Piperidines; Polymorphism, Single Nucleotide; Polyunsaturated Alkamides; Receptors, G-Protein-Coupled; Taste; Tongue	2016
Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:1 Topics: Alkaloids; Benzodioxoles; Capsaicin; Curcumin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Recombinant Proteins; Spices	2017
Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice. Molecules (Basel, Switzerland), 2018, Feb-07, Volume: 23, Issue:2 Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport; Capsaicin; Catechols; Doxorubicin; Fatty Alcohols; Mice; Phytochemicals; Piperidines; Polyunsaturated Alkamides; Tissue Distribution	2018
Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin. Molecules (Basel, Switzerland), 2018, Mar-02, Volume: 23, Issue:3 Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport; Caco-2 Cells; Capsaicin; Capsicum; Cell Line, Tumor; Doxorubicin; Drug Combinations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fluoresceins; Gene Expression; HCT116 Cells; Humans; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rhodamine 123	2018
Sinergism between alkaloids piperine and capsaicin with meglumine antimoniate against Leishmania infantum. Experimental parasitology, 2018, Volume: 188 Topics: Alkaloids; Antiprotozoal Agents; Benzodioxoles; Capsaicin; Chromatography, High Pressure Liquid; Drug Synergism; Inhibitory Concentration 50; Leishmania infantum; Leishmaniasis, Visceral; Magnetic Resonance Spectroscopy; Meglumine; Meglumine Antimoniate; Organometallic Compounds; Piperidines; Polyunsaturated Alkamides; Spectrophotometry, Ultraviolet	2018
Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti. Cellular and molecular biology (Noisy-le-Grand, France), 2018, Oct-30, Volume: 64, Issue:13 Topics: Alkaloids; Animals; Anthelmintics; Benzodioxoles; Biological Products; Brugia malayi; Capsaicin; Catalytic Domain; Curcumin; Drug Evaluation, Preclinical; Glutathione Transferase; Molecular Docking Simulation; Piperidines; Polyunsaturated Alkamides; Strychnine; Wuchereria bancrofti	2018
A distinct structural mechanism underlies TRPV1 activation by piperine. Biochemical and biophysical research communications, 2019, 08-20, Volume: 516, Issue:2 Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Hydrogen Bonding; Ion Channel Gating; Mice; Mutation; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; TRPV Cation Channels	2019
Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models. Planta medica, 2019, Volume: 85, Issue:13 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Capsaicin; Drug Delivery Systems; Nasal Mucosa; Pharmaceutical Vehicles; Piperidines; Polyunsaturated Alkamides; Sheep	2019
Comparative immunohistological study on using capsaicin, piperine, and okadaic acid for the transepithelial passage of the inactivated viral and bacterial vaccines in fish. Microscopy research and technique, 2020, Volume: 83, Issue:8 Topics: Adjuvants, Immunologic; Administration, Oral; Alkaloids; Animals; Bacterial Vaccines; Benzodioxoles; Biological Transport; Capsaicin; Fish Diseases; Okadaic Acid; Piperidines; Polyunsaturated Alkamides; Sea Bream; Viral Vaccines	2020
Inhibitory effect of Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2020, Volume: 55, Issue:9 Topics: Aflatoxins; Alkaloids; Antifungal Agents; Aspergillus; Benzodioxoles; Biosynthetic Pathways; Capsaicin; Capsicum; DNA-Binding Proteins; Fruit; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Transcription Factors	2020
Cytogenotoxicity and protective effect of piperine and capsaicin on meristematic cells of Allium cepa L. Anais da Academia Brasileira de Ciencias, 2021, Volume: 93, Issue:suppl 3 Topics: Alkaloids; Benzodioxoles; Capsaicin; DNA Damage; Onions; Piperidines; Plant Roots; Polyunsaturated Alkamides	2021
Turmeric, red pepper, and black pepper affect carotenoids solubilized micelles properties and bioaccessibility: Capsaicin/piperine improves and curcumin inhibits carotenoids uptake and transport in Caco-2 cells. Journal of food science, 2021, Volume: 86, Issue:11 Topics: Alkaloids; Benzodioxoles; Biological Availability; Caco-2 Cells; Capsaicin; Capsicum; Carotenoids; Curcuma; Curcumin; Humans; Micelles; Piper nigrum; Piperidines; Polyunsaturated Alkamides	2021
A Comparative Study on the Effect of Acute Pharyngeal Stimulation with TRP Agonists on the Biomechanics and Neurophysiology of Swallow Response in Patients with Oropharyngeal Dysphagia. International journal of molecular sciences, 2022, Sep-15, Volume: 23, Issue:18 Topics: Acrolein; Acyclic Monoterpenes; Alkaloids; Benzodioxoles; Biomechanical Phenomena; Capsaicin; Deglutition; Deglutition Disorders; Humans; Menthol; Piperidines; Polyunsaturated Alkamides; Retrospective Studies; Zinc	2022