capsaicin has been researched along with piperidines in 355 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (2.25) | 18.7374 |
| 1990's | 92 (25.92) | 18.2507 |
| 2000's | 175 (49.30) | 29.6817 |
| 2010's | 72 (20.28) | 24.3611 |
| 2020's | 8 (2.25) | 2.80 |
| Authors | Studies |
|---|---|
| Jancsó-Gábor, A; Szolcsányi, J | 1 |
| Lee, LY; Lou, YP; Lundberg, JM; Satoh, H | 2 |
| Maggi, CA; Meli, A; Patacchini, R | 1 |
| Jin, JG; Lu, YF; Nakayama, S; Takaki, M | 1 |
| Szolcsànyi, J | 2 |
| Goto, K; Ishikawa, T; Miyauchi, T; Saito, A; Sugishita, Y | 1 |
| Lawless, HT; Stevens, DA | 3 |
| Iwai, K; Kawada, T; Sakabe, S; Watanabe, T; Yamamoto, M | 1 |
| Micevych, PE; Szolcsanyi, J; Yaksh, TL | 1 |
| Amann, R; Donnerer, J; Holzer, P; Schuligoi, R | 1 |
| Bolser, DC; Chapman, RW; DeGennaro, FC; Hey, JA; O'Reilly, S | 1 |
| Ansay, M; Delaunois, A; Garbarg, M; Gustin, P | 1 |
| Hay, DW; Hubbard, WC; Undem, BJ | 1 |
| Advenier, C; Hirsch, A; Martin, CA; Molimard, M; Naline, E | 1 |
| Besson, G; Drazen, JM; Israel, E; Lilly, CM; Rodger, IW | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Mattiasson, A | 1 |
| Brain, SD; Newbold, P | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Meini, S | 1 |
| Drazen, JM; Haley, KJ; Hall, AE; Kobzik, L; Lilly, CM; Rodger, IW | 1 |
| Cioncolini, F; Figini, M; Geppetti, P; Javdan, P | 1 |
| Barthò, L; Holzer, P; Maggi, CA; Patacchini, R | 1 |
| Amann, R; Donnerer, J; Lanz, I; Schuligoi, R | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 1 |
| Bertrand, C; Desai, MC; Hoffman, JI; Husseini, WK; Nadel, JA; Petersson, G; Piedimonte, G; Snider, RM | 1 |
| Advenier, C; Emonds-Alt, X; Qian, Y | 1 |
| Bertrand, C; Desai, MC; Geppetti, P; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| Desai, MC; Hoffman, JI; Husseini, WK; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| DeSautel, MG; Maher, JW; Sandler, AD; Schlegel, JF | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Bryce, DK; Desai, MC; Ganong, A; Longo, KP; McLean, S; Reynolds, LS; Robinson, G; Rosen, T; Seymour, PA; Snider, RM | 1 |
| Maggi, CA; Meini, S | 1 |
| Bennett, KL; Clark, MG; Colquhoun, EQ; Dora, KA; Eldershaw, TP | 1 |
| Bannenberg, G; Kimland, M; Lundberg, JM; Moldéus, P; Ryrfeldt, A | 1 |
| Auberson, S; Lundberg, JM | 1 |
| Matui, T; Yoshii, K | 1 |
| Bryce, DK; Desai, MC; Heym, J; Longo, KP; McLean, S; Rosen, T; Schmidt, AW; Snider, RM | 1 |
| Bertrand, C; Foresi, A; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Buckner, CK; Campbell, J; Dea, D; Krell, RD; Lengel, D; Liberati, N; Miller, S; Shenvi, A; Stinson-Fisher, C | 1 |
| Vanner, S | 1 |
| Lou, YP; Lundberg, JM; Satoh, H | 1 |
| Everaert, E; Germonpré, PR; Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Beattie, DT; Brain, SD; Connor, HE; Escott, KJ | 1 |
| Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B | 1 |
| Conte, B; Cutrufo, C; Manzini, S | 1 |
| Chiyotani, A; Kameyama, S; Konno, K; Sakai, N; Takeda, Y; Tamaoki, J; Yamawaki, I | 1 |
| Kagoshima, M; Kodaira, H; Shimada, H; Tanaka, M | 1 |
| Ikeda, K; Kubota, H; Miyata, K; Orita, A; Tomioka, K; Yamada, T | 1 |
| Lin, Q; Peng, YB; Willis, WD | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC | 1 |
| Bartho, L; Holzer, P | 1 |
| Hodgson, WC; Hopkins, BJ; Sutherland, SK | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 1 |
| Juránek, I; Lembeck, F | 1 |
| Lundberg, JM; Rinder, J | 1 |
| Liu, L; Simon, SA | 1 |
| Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K | 1 |
| Burkholder, TP; Knippenberg, RW; Kudlacz, EM; Logan, DE | 1 |
| Caldwell, RW; Chiao, H | 1 |
| Ellis, JL; Sham, JS; Undem, BJ | 1 |
| Boucher, RC; Costa, DL; Lehmann, JR; McCarty, D; Pickles, RJ; Piedimonte, G | 1 |
| Dimitriadou, V; Garbarg, M; Luffau, G; Miller, HR; Newlands, GJ; Rouleau, A; Schwartz, JC; Trung Tuong, MD | 1 |
| Green, BG | 1 |
| Green, BG; Rentmeister-Bryant, H | 1 |
| Chen, PS; Rees, H; Sluka, KA; Tsuruoka, M; Willis, WD | 2 |
| Arguelles, JH; Baumann, TK; Martenson, ME | 1 |
| Criscuoli, M; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| MacNaughton, W; Moore, B; Vanner, S | 1 |
| Ishikawa, T; Menniti, FS; Mizutani, M; Nagahisa, A; Shimada, K; Shinjo, K; Taniguchi, K | 1 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Holst, JJ; Rasmussen, TN; Schmidt, PT | 1 |
| Ahrén, B; Karlsson, S; Sundler, F | 1 |
| Bereiter, DA; Bereiter, DF; Maclean, DB; Tonnessen, BH | 1 |
| Bullock, B; Dickerson, C; Undem, B; Winchurch, RA | 1 |
| Blackshaw, LA; Lynn, PA; Smid, SD; Templeman, R | 1 |
| D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Tonussi, CR | 1 |
| Carstens, E; Handwerker, HO; Kuenzler, N | 1 |
| Criscuoli, M; Giuliani, S; Lecci, A; Lippi, A; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Colquhoun, EQ; Eldershaw, TP; Geraghty, DP; Griffiths, CD | 1 |
| Bryce, DK; Coffman, KJ; Crawford, RT; Gohda, Y; Lowe, JA; McLean, S; Nagahisa, A; Nakane, M; Rosen, TJ; Tsuchiya, M | 1 |
| Fujiwara, H; Hirata, K; Kanazawa, H; Yoshikawa, J | 1 |
| Guo, JZ; Otsuka, M; Yoshioka, K | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Calixto, JB; Miguel, OG; Santos, AR; Yunes, RA | 1 |
| Bakhle, YS; Bell, C; Brogan, JD | 1 |
| Ko, MC; Woods, JH | 1 |
| Perfumi, MC; Piccoli, M; Romagnoli, S; Santoni, G; Spreghini, E | 1 |
| Geraghty, DP; Mazzone, SB | 1 |
| Aoyama, M; Arai, Y; Inaba, N; Lee, B; Onodera, S; Shibata, M; Tanaka, M; Yamaura, T | 1 |
| Aoyama, M; Arai, Y; Inaba, N; Nishizawa, A; Onodera, S; Sekine, Y; Shibata, M; Suzuki, T; Tanaka, M | 1 |
| Fujita, A; Nishiwaki, H; Takeuchi, K; Umeda, M | 1 |
| Barbara, G; Barthó, L; De Giorgio, R; Lecci, A; Lénárd, L; Maggi, CA; Patacchini, R; Stanghellini, V | 1 |
| Lee, LY; Wu, ZX | 1 |
| Carter, JD; Devlin, RB; Oortgiesen, M; Simon, SA; Veronesi, B | 1 |
| Kato, S; Kunikata, T; Takeuchi, K; Tanaka, A; Umeda, M | 1 |
| D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Souza, GE | 1 |
| Barthó, L; Benkó, R; Lázár, Z; Lénárd, L; Maggi, CA; Penke, B; Szolcsányi, J; Tóth, G | 1 |
| Calixto, JB; Campos, MM; Ferreira, PK | 1 |
| Doi, T; Ikeura, Y; Imai, S; Kamo, I; Natsugari, H; Okanishi, S | 1 |
| D'Agostino, G; Erbelding, D; Kilbinger, H | 1 |
| Chuang, H; Högestätt, ED; Julius, D; Movahed, P; Zygmunt, PM | 1 |
| Filer-Maerten, S; Hay, DW; Hieble, JP; Ruggieri, MR | 1 |
| Antunes, E; Costa, SK; da Silva, GR; Linardi, A | 1 |
| Farkas, B; Helyes, ZS; Németh, J; Oroszi, G; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| Andrews, PL; Hagiwara, H; Kakaimoto, S; Matsuki, N; Okada, F; Toyoda, M; Woods, AJ | 1 |
| Benbow, L; Corboz, MR; Egan, RW; Fawzi, AB; Hey, JA; Matasi, J; Rivelli, MA; Smith-Torhan, A; Tulshian, D; Zhang, H | 1 |
| Hazato, T; Inoue, M; Matsunaga, S; Ueda, H; Yamamoto, Y | 1 |
| Kim, D; Moore, BA; Vanner, S | 1 |
| Carr, MJ; Schechter, NM; Undem, BJ | 1 |
| Calignano, A; Désarnaud, F; Freund, TF; Giuffrida, A; Kátona, I; La Rana, G; Mackie, K; Piomelli, D | 1 |
| Dahl, JB; Jones, B; Petersen, KL; Rowbotham, MC; Segredo, V | 1 |
| Amadesi, S; Ansel, JC; Armstrong, CA; Bonaccorsi, P; Bunnett, NW; Geppetti, P; Gerard, NP; Grady, EF; Klein, R; Lu, B; Luger, TA; Olerud, JE; Scholzen, TE; Steinhoff, M | 1 |
| Brockie, HC; Craib, SJ; Di Marzo, V; Gibson, TM; Leslie, M; Pashmi, G; Pertwee, RG; Ross, RA | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Chapman, V; Kendall, DA; Millns, PJ | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Capasso, F; Capasso, R; Di Carlo, G; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Kendall, DA; Ralevic, V | 1 |
| Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G | 2 |
| Manning, BP; Mawe, GM | 1 |
| Gitlin, JM; Mitchell, JA; Stanford, SJ | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; O'Donoghue, DP; Selve, N | 1 |
| Corboz, MR; Egan, RW; Fernandez, X; Hey, JA | 1 |
| Hayashi, K; Ishii, A; Kaise, T; Karasawa, A; Ohmori, K; Sano, J; Sato, H | 1 |
| Heitmiller, DR; Hodges, J; Johanek, LM; Nader, N; Simone, DA; Turner, M | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Craib, SJ; Ellington, HC; Pertwee, RG; Ross, RA | 1 |
| Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT | 1 |
| Erbelding, D; Kilbinger, H; Mang, CF | 1 |
| Antunes, E; Brain, SD; Camargo, E; Costa, SK; De Nucci, G; Esquisatto, LC; Gambero, A | 1 |
| Hataishi, R; Hayashi, I; Imasaki, T; Kobayashi, H; Majima, M; Tomita, T | 1 |
| Kashon, ML; Krajnak, KM; Kwong, K; Lee, LY; Wise, PM; Wu, ZX | 1 |
| Bottrill, FE; Ford, WR; Hiley, CR; Ho, WS; White, R | 1 |
| Boachie-Ansah, G; Grainger, J | 1 |
| Fowler, CJ; Jacobsson, SO; Wallin, T | 1 |
| Brain, SD; Gerard, NP; Rawlingson, A | 1 |
| Horie, S; Murayama, T; Tsuchiya, S; Uchida, M; Watanabe, K; Yamamoto, H | 1 |
| Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K | 1 |
| Lever, IJ; Malcangio, M | 1 |
| Eltorp, CT; Hansen, AJ; Ingvardsen, BK; Jørgensen, TK; Lundbaek, JA; Olsen, UB; Thomsen, C | 1 |
| Antunes, E; Brain, SD; Costa, SK; De Nucci, G; Esquisatto, LC; Juliano, L; Moreno, RA | 1 |
| Ko, MC; McKnight, AT; Naughton, NN; Rice, KC; Song, MS; Traynor, JR; Woods, JH | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Nocerino, E; Pinto, A; Sautebin, L | 1 |
| Ajioka, H; Matsuura, N; Nakano, M; Nishihara, K; Nozawa, Y | 1 |
| Naidu, KA; Thippeswamy, NB | 1 |
| Berrino, L; Cuomo, D; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F | 1 |
| Baker, D; Bifulco, M; Bisogno, T; Bridges, D; Brooks, JW; Brown, P; Di Marzo, V; Hankey, DJ; Jaggar, SI; Ledent, C; Pryce, G; Rice, AS | 1 |
| Chapnick, BM; Howlett, AC; Mukhopadhyay, S | 1 |
| Cameron, NE; Cotter, MA; Ellington, HC; Ross, RA | 1 |
| Ashton, D; Fransen, JF; Hens, KA; Heylen, L; Hillen, LC; Janssens, F; Jurzak, MR; Leysen, JE; Mahieu, M; Megens, AA; Vermeire, JC; Vermote, PC | 1 |
| Anthes, JC; Billah, M; Carruthers, N; Chapman, RW; Corboz, M; Crawley, Y; Cuss, FM; Eckel, S; Egan, RW; Fernandez, X; Greenfeder, S; Hey, JA; Kreutner, W; McLeod, R; Piwinski, J; Reichard, G; Richard, C; Rizzo, C; Sehring, S; Shih, NY; Ting, P | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, A; Russo, A; Sautebin, L | 1 |
| Freund, TF; Hájos, N | 1 |
| Egan, RW; Hey, JA; Jia, Y; McLeod, RL; Parra, LE; Wang, X | 1 |
| Bilbao, A; Cippitelli, A; Del Arco, I; Ferrer, B; Gómez, R; Nava, F; Navarro, M; Piomelli, D; Rodríguez de Fonseca, F; Trigo, JM | 1 |
| Aoi, M; Kagawa, S; Kato, S; Kohama, K; Mimaki, H; Satoshi, T; Takeuchi, K | 1 |
| Helyes, Z; Jakab, B; Németh, J; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| Adinolfi, B; Breschi, MC; Calderone, V; Martinotti, E; Nieri, P; Testai, L | 1 |
| Kurosawa, M; Terano, A; Watanobe, H; Yoneda, M | 1 |
| Ahluwalia, J; Bevan, S; Nagy, I; Urban, L; Yaqoob, M | 1 |
| Ates, M; Gühring, H; Hamza, M; Seidel, K | 1 |
| de Miguel, R; De Petrocellis, L; Di Marzo, V; Fernández-Ruiz, J; Lastres-Becker, I; Makriyannis, A | 1 |
| Kaminski, NE; Li, J; Wang, DH | 1 |
| Bang, R; Kiemer, AK; Neuhuber, WL; Sass, G; Tiegs, G; Vollmar, AM | 1 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Dey, RD; Satterfield, BE; Wu, ZX | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Ahluwalia, J; Bevan, S; Nagy, I; Urban, L | 1 |
| Curry, R; Eisenach, JC; Hood, DD | 1 |
| Horie, S; Murayama, T; Someya, A; Yamamoto, H | 1 |
| Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Hele, DJ; Patel, HJ; Venkatesan, P; Yacoub, MH | 1 |
| Itoh, M; Joh, T; Kasugai, K; Nomura, T; Ohara, H; Oshima, T; Seno, K; Sobue, M; Suzuki, H; Yokoyama, Y | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Kato, S; Nagahama, K; Takeuchi, K; Yamato, M | 1 |
| Adler-Graschinsky, E; Celuch, SM; del Carmen García, M | 1 |
| Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C | 1 |
| Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Compton, SJ; Garcia-Villar, R; Grady, E; Hollenberg, MD; Nguyen, C; Steinhoff, M; Vergnolle, N; Wallace, JL | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC | 1 |
| Farquhar-Smith, WP; Rice, AS | 1 |
| Dougalis, A; Lees, G | 1 |
| Akerman, S; Goadsby, PJ; Kaube, H | 1 |
| Capparelli, A; Mulè, F; Pizzuti, R; Vergnolle, N | 1 |
| Green, BG; Hayes, JE | 1 |
| Evans, RM; Ross, RA; Scott, RH | 1 |
| Bánvölgyi, A; Brain, SD; Ghosh, M; Helyes, ZS; Melegh, B; Pintér, E; Pozsgai, G; Szolcsányi, J | 1 |
| Amantini, C; Lucciarini, R; Perfumi, M; Piccoli, M; Pompei, P; Santoni, G | 1 |
| Edwards, M; Schaffler, K; Seibel, K; Thomsen, M | 1 |
| Belai, A; Horie, S; Michael, GJ; Murayama, T; Priestley, JV; Uchida, M; Watanabe, K; Yamamoto, H | 1 |
| Godlewski, G; Malinowska, B; Schlicker, E | 1 |
| Baamonde, A; Fresno, MF; Hidalgo, A; Lastra, A; Llames, S; Meana, A; Menéndez, L | 1 |
| Adler-Graschinsky, E; Becu-Villalobos, D; Celuch, SM; Huidobro-Toro, JP; Orliac, ML; Peroni, RN | 1 |
| Duncan, M; Kendall, DA; Ralevic, V | 1 |
| Chapman, V; Kendall, DA; Millns, PJ; Sagar, DR; Smart, D; Smith, PA | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Colleoni, M; Costa, B; Franke, C; Giagnoni, G; Trovato, AE | 1 |
| Ahluwalia, A; Chauhan, S; Davis, C; De Felipe, C; Hunt, S; Kabir, J; Kotsonis, P; Oh, U; Scotland, RS | 1 |
| Bembry, J; Chen, Y; Golech, SA; Lenz, F; McCarron, RM; Mechoulam, R; Shohami, E; Spatz, M | 1 |
| Kato, S; Okayama, M; Takeuchi, K; Tsubouchi, R | 1 |
| Ajioka, H; Horie, S; Kunieda, K; Murayama, T; Someya, A | 1 |
| Bianchi, R; Borsani, E; Buffoli, B; Rezzani, R; Ricci, F; Rodella, LF | 1 |
| Brzozowski, T; Ceranowicz, P; Dembiński, A; Dembiński, M; Konturek, SJ; Pawlik, WW; Warzecha, Z | 1 |
| Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C | 1 |
| Gunthorpe, MJ; McNamara, FN; Randall, A | 1 |
| Inoue, A; Kawamoto, M; Nakata, Y; Oshita, K; Tang, HB; Yuge, O | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Cadet, JL; Chen, J; Deng, X; Errico, S; Freed, WJ; Lee, CT | 1 |
| Breuer, A; Fride, E; Hanus, L; Ponde, D | 1 |
| Maor, Y; Mechoulam, R; Pertwee, RG; Stevenson, LA; Thomas, A | 1 |
| O'Reilly, M; Patton, D; Vanner, S | 1 |
| Chapman, V; Kelly, S; Kendall, DA; Millns, PJ; O'Shaughnessey, CT; Sagar, DR | 1 |
| Easton, AS; Fraser, PA; Hu, DE | 1 |
| Adler-Graschinsky, E; Briones, R; Huidobro-Toro, JP; Orliac, ML; Poblete, IM | 1 |
| Abe, T; Arisaka, O; Morimoto, H; Ohori, M; Yamada, Y; Yoshihara, S | 1 |
| Farthing, JN; Gutierrez, T; Hohmann, AG; Suplita, RL | 1 |
| Kaminski, NE; Wang, DH; Wang, Y | 1 |
| Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM | 1 |
| Cowan, A; Ding, Z; Rawls, SM | 2 |
| Fujimoto, S; Kunimatsu, M; Mori, M; Tsushima, H | 1 |
| Braida, D; Guerini-Rocco, C; Pegorini, S; Sala, M; Zani, A | 1 |
| Aoi, Y; Fukushima, K; Kato, S; Takeuchi, K | 1 |
| Donnerer, J; Liebmann, I | 1 |
| Kuramasu, A; Mobarakeh, JI; Sakurada, S; Takahashi, K; Yanai, K | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| Chabot, JG; Jhamandas, K; Ma, W; Quirion, R; Trang, T | 1 |
| Baik, SK; Dehpour, AR; Gaskari, SA; Lee, SS; Liu, H; Moezi, L | 1 |
| Baron, R; Chung, JM; Chung, K; Kim, HK; Lee, I; Schattschneider, J | 1 |
| Boudaka, A; Kobayashi, H; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J | 1 |
| Budai, D; Khasabov, SG; Mantyh, PW; Simone, DA | 1 |
| Harada, N; Okajima, K | 1 |
| Ali, N; Chapman, V; Chimenti, M; de Lago, E; Fernandez-Ruiz, J; Kendall, DA; Millns, PJ; Ryland, E | 1 |
| De Ridder, D; Gevaert, T; Hutchings, G; Nilius, B; Vandepitte, J; Vriens, J | 1 |
| Avezaat, CJ; de Vries, R; Garrelds, IM; Gupta, S; Lozano-Cuenca, J; MaassenVanDenBrink, A; Saxena, PR; van Kats, JP; Villalón, CM | 1 |
| Matsuda, H; Nagatomo, A; Ochi, M; Yoshikawa, M | 1 |
| Affeltranger, MA; Balaban, CD; McBurney, DH | 1 |
| Cristino, L; Davison, JS; Di Marzo, V; Guglielmotti, V; Oland, LD; Pittman, QJ; Sharkey, KA; Starowicz, K; Van Sickle, MD | 1 |
| Bianchi, R; Borsani, E; Labanca, M; Rodella, LF | 1 |
| Srinivasan, K; Suresh, D | 3 |
| Agrò, AF; Bagetta, G; Bari, M; Cerulli, A; Corasaniti, MT; De Simone, C; Gasperi, V; Maccarrone, M; Morrone, LA; Nucci, C; Tartaglione, R; Terrinoni, A | 1 |
| Herradón, E; López-Miranda, V; Martín, MI | 1 |
| Kendall, DA; Ralevic, V; Wilkinson, JD | 1 |
| Wang, DH; Wang, Y | 1 |
| Hatanaka, Y; Iwatani, Y; Jin, X; Kawasaki, H; Sugiyama, T | 1 |
| d'amico, A; de Filippis, D; de Man, JG; de Winter, BY; Esposito, G; Herman, AG; Iuvone, T; Pelckmans, PA; Steardo, L | 1 |
| Barrett, E; Xu, F; Xu, J | 1 |
| Kamei, C; Kuyama, S; Ogawa, M; Yokota, E | 1 |
| Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A | 2 |
| Amagase, K; Hayashi, S; Komatsu, Y; Kotani, T; Murashima, Y; Nakagiri, A; Takeuchi, K | 1 |
| Chang, HM; Chen, GD; Chiu, CH; Huang, PC; Lai, CH; Lai, CY; Lee, SD; Lin, TB; Peng, HY; Tung, KC | 1 |
| Brandt, MR; Calvo, RR; Cheung, WS; Flores, CM; Hutchinson, T; Player, MR; Stone, DR; Tounge, BA; Zhang, SP | 1 |
| Bitencourt, RM; Pamplona, FA; Takahashi, RN | 1 |
| De Felice, M; Fioravanti, B; Gardell, LR; Ibrahim, M; King, T; Lai, J; Luo, MC; Malan, TP; Medler, KA; Ossipov, MH; Porreca, F; Stucky, CL; Vanderah, TW; Yamamura, HI | 1 |
| Futamura, M; Goto, S; Ito, K; Kimoto, I; Kimura, R; Miyake, M; Sakamoto, T | 1 |
| Boudaka, A; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J | 1 |
| Atorino, G; Aviello, G; Borrelli, F; Capasso, R; Pagano, E; Romano, B | 1 |
| Caldwell, JP; Fawzi, A; Fernandez, X; Matasi, JJ; McLeod, RL; Tulshian, DB; Zhang, H | 1 |
| Donnerer, J; Liebmann, I; Schuligoi, R | 1 |
| Hatakeyama, D; Kato, K; Long, NK; Makita, H; Shibata, T; Takeda, T; Toida, M; Yamashita, T | 1 |
| Fantegrossi, WE; Galuska, CM; Ko, MC; Prinssen, EP; Wichmann, J; Woods, JH | 1 |
| Hayes, D; Lee, LY; Lin, RL | 1 |
| Jean, A; Lebrun, B; Roux, J; Trouslard, J; Wanaverbecq, N | 1 |
| Buschmann, H; Grosse Maestrup, E; Holenz, J; Schepmann, D; Vela, JM; Wiese, C; Wünsch, B | 1 |
| Chichorro, JG; Motta, EM; Rae, GA | 1 |
| Challapalli, SC; Smith, PJ; Zhang, F | 1 |
| Naidu, KA; Raghavendra, RH | 1 |
| Bien, MY; Hsu, CC; Huang, YT; Kou, YR; Lin, YS; Ruan, T | 1 |
| Kondo, S; Matsumoto, M; Ueda, H; Usdin, TB | 1 |
| Hamity, MV; Hammond, DL; White, SR | 1 |
| Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR | 1 |
| Calò, G; Guerrini, R; Hu, E; Ko, MC | 1 |
| Chen, W; Lao, L; Marvizón, JC; Zhang, G | 1 |
| Fujihara, H; Hashimoto, H; Nagatomo, T; Ohbuchi, T; Otsubo, H; Saito, T; Suzuki, H; Ueta, Y; Yokoyama, T | 1 |
| Kushmerick, C; Morini, Vde C; Naves, LA; Silveira, NA; Silveira, PE | 1 |
| Prakash, UN; Srinivasan, K | 4 |
| Correa, EA; Echeverri, F; Högestätt, ED; Sterner, O; Zygmunt, PM | 1 |
| Guindon, J; Hohmann, AG; Spradley, JM | 1 |
| Azuma, M; Kang, KS; Matsuda, K; Sakashita, A; Shioda, S; Yahashi, S | 1 |
| Beattie, RE; Knopp, K; Liu, B; Sher, E; Ursu, D | 1 |
| Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K | 1 |
| Alexander, SP; Randall, MD; Wheal, AJ | 1 |
| Capó-Aponte, JE; Pan, Z; Reinach, PS; Wang, Z; Yang, H; Zhang, F | 1 |
| Akiba, Y; Kaunitz, JD | 1 |
| Karaki, S; Kuwahara, A | 1 |
| Chen, C; Chen, X; Zhang, J | 1 |
| Almeida, MC; Balaskó, M; Dogan, MD; Eales, J; Gavva, NR; Molchanova, AY; Oliveira, DL; Patel, S; Pétervári, E; Romanovsky, AA; Steiner, AA; Székely, M; Wanner, SP | 1 |
| Goadsby, PJ; Kavantzas, N; Knight, YE; Lasalandra, M; Mitsikostas, DD | 1 |
| Fujita, T; Jiang, CY; Kumamoto, E; Mizuta, K; Piao, LH; Yang, L; Yue, HY | 1 |
| Hayase, T | 1 |
| Aguiar, DC; Casarotto, PC; Guimarães, FS; Moreira, FA; Terzian, AL; Wotjak, CT; Zangrossi, H | 1 |
| Attkins, N; Bateman, L; Bictash, M; Doyle, R; Ivarsson, M; Neal-Morgan, S; Pullen, N; Ramsey, S; Russell, R; Turner, J; Weibley, L | 1 |
| Beitz, AJ; Brink, TS; Khasabov, SG; Pacharinsak, C; Simone, DA | 1 |
| Henry, PJ; Mann, TS; Taylor, SJ | 1 |
| Jin, H; Kawasaki, H; Kitamura, Y; Koyama, T; Sun, P; Takatori, S; Tangsucharit, P; Zamami, Y | 1 |
| Baranowska-Kuczko, M; Kozłowska, H; MacLean, MR; Malinowska, B | 1 |
| Aguiar, DC; Fogaça, MV; Guimarães, FS; Moreira, FA | 1 |
| Castellaneta, E; Cava, E; Ceccarelli, P; Claudia, S; Donini, LM; Edda, C; Emanuela, C; Faliva, M; Fioravanti, M; Klersy, C; Luciano, S; Maddalena, P; Opizzi, A; Paola, C; Paolini, M; Perna, S; Rondanelli, M; Savina, C; Scavone, L; Solerte, SB | 1 |
| Claudia, S; Donini, LM; Edda, C; Emanuela, C; Faliva, M; Fioravanti, M; Klersy, C; Luciano, S; Maddalena, P; Opizzi, A; Paola, C; Perna, S; Rondanelli, M; Solerte, SB | 1 |
| Srinivasan, K | 1 |
| Fischer, MJ; Kageneck, C; Messlinger, K; Nixdorf-Bergweiler, BE | 1 |
| Abílio, VC; Almeida, V; Calzavara, MB; Crippa, JA; Hallak, JE; Levin, R; Peres, FF; Suiama, MA; Zuardi, AW | 1 |
| Alvarez-Berdugo, D; Clavé, P; Jiménez, M; Rofes, L | 1 |
| Andresen, MC; Fawley, JA; Hofmann, ME | 1 |
| Lee, M | 1 |
| Dale, CS; Ferro, ES; Fogaça, MV; Gozzo, FC; Guimarães, FS; Rioli, V; Sonego, AB | 1 |
| Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K | 1 |
| Calzetta, L; Capuano, A; Cazzola, M; Facciolo, F; Luongo, L; Maione, S; Matera, MG; Page, C; Rinaldi, B; Rogliani, P | 1 |
| Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM | 1 |
| Cho, YM; Kiriyama, Y; Nishikawa, A; Ogawa, K; Shi, L; Takasu, S; Tatematsu, M; Toyoda, T; Tsukamoto, T | 1 |
| Bartho, L; Bencsik, T; Sandor, Z | 1 |
| Decorps, J; Fromy, B; Gohin, S; Sigaudo-Roussel, D | 1 |
| Khan, M; Ma, T; Maryam, A; Mehmood, T; Zhang, Y | 1 |
| Hott, SC; Lisboa, SF; Resstel, LB; Uliana, DL | 1 |
| Hayes, JE; McGeary, JE; Nolden, AA | 1 |
| He, Q; Jian, T; Lan, L; Shi, H; Tang, M; Tang, Z; Wang, C; Wang, Z; Wu, G; Yang, N; Yang, Y; Yu, G; Yuan, X; Zhu, C | 1 |
| Hu, SS | 1 |
| Adams, MJ; Geraghty, DP; Kunde, DA; Omari, SA | 1 |
| Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA | 1 |
| Li, HB; Li, S; Li, Y; Xu, DP; Zheng, J; Zhou, Y | 1 |
| Hinz, B; Ivanov, I; Scholl, A | 1 |
| Lim, LY; Shamsi, S; Tan, RS; Tan, ZJ; Tran, H | 1 |
| Coderre, TJ; Ding, S; Gyawali, S; Laferrière, A; Mahboubi, H; Mickeviciute, A; Nasir, H; Ragavendran, JV; Stochaj, U | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
| Giesler, GJ; Khasabov, SG; Malecha, P; Noack, J; Simone, DA; Tabakov, J | 1 |
| Bae, IH; Burns, A; Choi, G; Choi, JK; Fagg, R; Gatfield, KM; Lee, CS; Naidoo, AA; Park, M; Park, YH; Powell, AJ; Vidgeon-Hart, M | 1 |
| Fatahi, Z; Haghparast, A; Khani, A; Rainer, G; Reisi, Z | 1 |
| Kim, TH; Shin, BS; Shin, S; Yoo, SD | 1 |
| Krstin, S; Li, H; Wang, S; Wink, M | 1 |
| Carneiro de Freitas, JC; Macedo Rondon, FC; Maia de Morais, S; Pereira Mendes, FN; Pinto Vieira, ÍG; Vieira-Araújo, FM | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M | 1 |
| Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L | 1 |
| Ahmad, I; Baig, MH; Imran, M; Kausar, MA; Saeed, M; Shahid, S | 1 |
| Dong, Y; Tian, Y; Vu, S; Yang, F; Yarov-Yarovoy, V; Yin, Y; Zheng, J | 1 |
| Gerber, W; Hamman, J; Kotzé, A; Steyn, D; Svitina, H; Weldon, C | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Gaafar, AY; Istiqomah, I; Kawato, Y; Nakai, T; Ninomiya, K; Yamashita, H; Younes, A | 1 |
| Buitimea-Cantúa, GV; Buitimea-Cantúa, NE; Hernández-Morales, A; Magaña-Barajas, E; Molina-Torres, J; Rocha-Pizaña, MDR | 1 |
| Chung, YC; Jin, BK; Wi, R | 1 |
| Hara, K; Haranishi, Y; Terada, T | 1 |
| Almeida, PM; Dias, MS; Junior, EPV; Martins, FA; Peron, AP; Santos, BCD | 1 |
| Ambedkar, R; Baskaran, V; Hanumanthappa, M; Lakshminarayana, R; Perumal, MK; Shilpa, S; Shwetha, HJ | 1 |
| Alvarez-Berdugo, D; Clavé, P; Ortega, O; Rofes, L; Tomsen, N | 1 |
3 review(s) available for capsaicin and piperidines
| Article | Year |
|---|---|
Antioxidant potential of spices and their active constituents.
Topics: Alkaloids; Anti-Inflammatory Agents; Antimutagenic Agents; Antioxidants; Benzodioxoles; Capsaicin; Cardiotonic Agents; Catechols; Curcumin; Eugenol; Fatty Alcohols; Garlic; Humans; Neoplasms; Onions; Oxidative Stress; Phenols; Piperidines; Polyunsaturated Alkamides; Spices; Trigonella | 2014 |
Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals.
Topics: Abietanes; Alkaloids; Allyl Compounds; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzodioxoles; beta Carotene; Biflavonoids; Capsaicin; Catechin; Catechols; Curcumin; Dietary Supplements; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fatty Alcohols; Furocoumarins; Humans; Indoles; Limonins; Neoplasms; Phytotherapy; Piperidines; Polyunsaturated Alkamides; Proanthocyanidins; Quercetin; Resveratrol; Stilbenes; Sulfides; Tea; Triterpenes; Xanthophylls | 2015 |
Spices for Prevention and Treatment of Cancers.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Benzodioxoles; Benzoquinones; Capsaicin; Capsicum; Cell Proliferation; Crocus; Curcuma; Curcumin; Garlic; Humans; Neoplasms; Nigella sativa; Phytotherapy; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Spices; Zingiber officinale | 2016 |
8 trial(s) available for capsaicin and piperidines
| Article | Year |
|---|---|
Rapid recovery from capsaicin desensitization during recurrent stimulation.
Topics: Administration, Oral; Adult; Alkaloids; Analysis of Variance; Benzodioxoles; Capsaicin; Citric Acid; Depression, Chemical; Dose-Response Relationship, Drug; Female; Guaiacol; Humans; Irritants; Logistic Models; Male; Piperidines; Polyunsaturated Alkamides; Reference Values; Stimulation, Chemical; Time Factors; Tongue | 1996 |
Effect of remifentanil on pain and secondary hyperalgesia associated with the heat--capsaicin sensitization model in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain Measurement; Piperidines; Remifentanil | 2001 |
Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Male; Nausea; Oxyhemoglobins; Pain Measurement; Piperidines; Remifentanil | 2003 |
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hot Temperature; Humans; Hydromorphone; Hyperalgesia; Lamotrigine; Pain; Pain Measurement; Piperidines; Remifentanil; Triazines | 2003 |
Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser.
Topics: Adult; Arousal; Capsaicin; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; Histamine H1 Antagonists; Humans; Hyperalgesia; Lasers; Male; Pain Measurement; Piperidines; Skin | 2004 |
Palliative effect of lafutidine on oral burning sensation.
Topics: Acetamides; Aged; Burning Mouth Syndrome; Capsaicin; Female; Histamine H2 Antagonists; Humans; Male; Neurons, Afferent; Pain Measurement; Palliative Care; Piperidines; Pyridines; Sensory System Agents; Treatment Outcome | 2009 |
Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects.
Topics: Adipokines; Adult; Alkaloids; Benzodioxoles; Capsaicin; Carnitine; Catechin; Diet, Reducing; Dietary Supplements; Double-Blind Method; Female; Humans; Inflammation Mediators; Insulin Resistance; Male; Middle Aged; Overweight; Piperidines; Polyunsaturated Alkamides; Time Factors; Weight Loss; Young Adult | 2013 |
Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects.
Topics: Adult; Alkaloids; Area Under Curve; Basal Metabolism; Benzodioxoles; Capsaicin; Carnitine; Catechin; Dietary Supplements; Double-Blind Method; Fatty Acids, Nonesterified; Female; Glucagon-Like Peptide 1; Glycerol; Humans; Male; Middle Aged; Obesity; Phytotherapy; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Satiation; Satiety Response | 2013 |
344 other study(ies) available for capsaicin and piperidines
| Article | Year |
|---|---|
Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents.
Topics: Animals; Butanones; Capsaicin; Condiments; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Homovanillic Acid; Pain; Piperidines; Rats; Sensory Receptor Cells; Structure-Activity Relationship | 1975 |
Inhibitory effects of capsazepine and the NK2 antagonist SR 48968 on bronchoconstriction evoked by sensory nerve stimulation in guinea-pigs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Electric Stimulation; Female; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1992 |
Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Curcumin; Eugenol; In Vitro Techniques; Isothiocyanates; Male; Muscle Contraction; Mustard Plant; Nerve Endings; Neurons, Afferent; Piperidines; Plant Extracts; Plant Oils; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Ruthenium Red; Tetrodotoxin; Thiocyanates | 1990 |
Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with capsaicin.
Topics: Alkaloids; Animals; Anticonvulsants; Atropine; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Endings; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Ruthenium Red; Substance P; Tachyphylaxis; Tetrodotoxin | 1990 |
Effect of capsaicin, resiniferatoxin and piperine on ethanol-induced gastric ulcer of the rat.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Diterpenes; Ethanol; Female; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stomach Ulcer | 1990 |
Involvement of calcitonin gene-related peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria.
Topics: Alkaloids; Animals; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Neuropeptides; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tachyphylaxis | 1989 |
Responses by humans to oral chemical irritants as a function of locus of stimulation.
Topics: Adolescent; Adult; Alkaloids; Benzodioxoles; Capsaicin; Female; Humans; Male; Mouth; Piperidines; Polyunsaturated Alkamides; Sensation; Time Factors; Tongue | 1988 |
Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats.
Topics: Adrenal Medulla; Alkaloids; Animals; Benzodioxoles; Capsaicin; Catecholamines; Condiments; Epinephrine; Guaiacol; Intestinal Absorption; Kinetics; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains | 1988 |
Enhancement of responses to sequential presentation of oral chemical irritants.
Topics: Alkaloids; Benzodioxoles; Capsaicin; Drug Administration Schedule; Drug Synergism; Humans; Irritants; Mouth; Piperidines; Polyunsaturated Alkamides | 1987 |
Putting out the fire: effects of tastants on oral chemical irritation.
Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Citrates; Citric Acid; Humans; Piperidines; Polyunsaturated Alkamides; Quinine; Sodium Chloride; Sucrose; Taste; Water | 1986 |
Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Cholecystokinin; Enkephalin, Methionine; Fatty Acids, Unsaturated; Ganglia, Spinal; Kainic Acid; Male; Microscopy, Fluorescence; Nociceptors; Peptides; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Somatostatin; Substance P | 1983 |
Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Denervation; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Muscle, Smooth; Neuromuscular Junction; Pain; Piperidines; Polyunsaturated Alkamides; Tetrodotoxin; Trachea | 1983 |
The non-peptide NK1 receptor antagonist SR140333 produces long-lasting inhibition of neurogenic inflammation, but does not influence acute chemo- or thermonociception in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Capsaicin; Dinoprostone; Female; Hot Temperature; Injections, Intravenous; Injections, Subcutaneous; Male; Motor Activity; Nerve Tissue; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1995 |
Pharmacological studies of allergic cough in the guinea pig.
Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsaicin; Chlorpheniramine; Cimetidine; Codeine; Cough; Drug Hypersensitivity; Guinea Pigs; Hexamethonium; Histamine Antagonists; Indomethacin; Injections, Subcutaneous; Ipratropium; Loratadine; Male; Ovalbumin; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2 | 1995 |
Modulation of acetylcholine, capsaicin and substance P effects by histamine H3 receptors in isolated perfused rabbit lungs.
Topics: Acetylcholine; Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Endothelium; Female; Histamine Agonists; Histamine Antagonists; Imidazoles; In Vitro Techniques; Lung; Male; Nerve Fibers; Piperidines; Pulmonary Edema; Rabbits; Receptors, Histamine H3; Serotonin; Substance P; Thiourea | 1995 |
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dicarboxylic Acids; Endothelins; Epithelium; Guinea Pigs; Histamine Release; In Vitro Techniques; Kinetics; Leukotriene Antagonists; Male; Muscle Contraction; Neurokinin A; Piperidines; Prostaglandins; Receptors, Tachykinin; SRS-A; Tetrodotoxin; Trachea | 1993 |
Contractile effects of bradykinin on the isolated human small bronchus.
Topics: Acetylcholine; Aged; Atropine; Benzamides; Biphenyl Compounds; Bradykinin; Bronchi; Bronchoconstriction; Capsaicin; Humans; In Vitro Techniques; Indomethacin; Middle Aged; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Bradykinin; Ruthenium Red; Tetrodotoxin | 1994 |
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1994 |
Capsaicin-induced bladder hyperactivity in normal conscious rats.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Compounds; Indoles; Isoindoles; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1994 |
An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Catalase; Dexamethasone; Drug Interactions; Edema; Histamine; Indoles; Indomethacin; Injections, Intradermal; Injections, Intravenous; Isoindoles; Male; Piperidines; Rabbits; Regional Blood Flow; Ruthenium Red; Skin; Substance P; Vasodilator Agents | 1995 |
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder | 1995 |
Substance P-induced histamine release in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Mast Cells; Perfusion; Piperidines; Pyrilamine; Receptors, Histamine; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Involvement of tachykinins in plasma extravasation induced by bradykinin and low pH medium in the guinea-pig conjunctiva.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Conjunctiva; Guinea Pigs; Hydrogen-Ion Concentration; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Bradykinin; Substance P; Tachykinins | 1995 |
Activity of SR 142801 at peripheral tachykinin receptors.
Topics: Analysis of Variance; Animals; Binding, Competitive; Capsaicin; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Portal Vein; Pulmonary Artery; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 1995 |
Histamine-induced edema in the rat paw--effect of capsaicin denervation and a CGRP receptor antagonist.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Capsaicin; Denervation; Edema; Foot; Histamine; Male; Miotics; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1995 |
Urodynamic effects of intravesical resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Diterpenes; Female; Neurotoxins; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Urethral Obstruction; Urinary Bladder; Urodynamics | 1995 |
Neurogenic vasodilation in the rat nasal mucosa involves neurokinin1 tachykinin receptors.
Topics: Animals; Capsaicin; Male; Neurons, Afferent; Olfactory Mucosa; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Vasodilation | 1993 |
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertonic Solutions; Neurokinin A; Neurons, Afferent; Piperidines; Platelet Activating Factor; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium Chloride; Stimulation, Chemical; Substance P; Trachea; Tracheal Diseases | 1993 |
NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways.
Topics: Animals; Capsaicin; Inflammation; Male; Microspheres; Neurons, Afferent; Peptidyl-Dipeptidase A; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Regional Blood Flow; Respiratory System; Respiratory Tract Diseases; Substance P; Tachykinins; Vasodilation | 1993 |
Neuroregulation of a chemosensitive afferent system in the canine distal esophagus.
Topics: Afferent Pathways; Animals; Atropine; Blood Pressure; Capsaicin; Chemoreceptor Cells; Dogs; Esophagus; Hexamethonium; Hexamethonium Compounds; Mucous Membrane; Nociceptors; Piperidines; Pressure; Pulse; Respiration; Substance P; Tetrodotoxin; Vagotomy | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.
Topics: Animals; Binding, Competitive; Calcium Channels; Capillary Permeability; Capsaicin; Cells, Cultured; Cricetinae; Guinea Pigs; Humans; In Vitro Techniques; Locus Coeruleus; Male; Motor Activity; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P | 1993 |
Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation.
Topics: Adenosine Triphosphate; Animals; Atropine; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder | 1994 |
Resiniferatoxin and piperine: capsaicin-like stimulators of oxygen uptake in the perfused rat hindlimb.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Hindlimb; Male; Nitroglycerin; Oxygen Consumption; Perfusion; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 1994 |
Sensory neuropeptide-mediated bronchoconstriction of the guinea pig lung by diamide; a comparison to hydrogen peroxide.
Topics: Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Diamide; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Thromboxanes | 1994 |
Lactic acid-induced plasma protein extravasation in rat airways by stimulation of sensory nerves and NK1 receptor activation.
Topics: Animals; Benzamides; Blood Proteins; Bronchi; Capsaicin; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indoles; Isoindoles; Lactates; Lactic Acid; Male; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiratory Physiological Phenomena; Respiratory System; Trachea | 1993 |
Taste responses of bullfrog to pungent stimuli.
Topics: Adaptation, Physiological; Alkaloids; Animals; Benzodioxoles; Capsaicin; Chemoreceptor Cells; Electrophysiology; Glossopharyngeal Nerve; In Vitro Techniques; Isothiocyanates; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Rana catesbeiana; Regional Blood Flow; Sensory Thresholds; Stimulation, Chemical; Taste; Tongue | 1994 |
CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor.
Topics: Albuterol; Animals; Binding, Competitive; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Thiorphan; Verapamil | 1993 |
Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs.
Topics: Aerosols; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchoconstriction; Capsaicin; Glycopeptides; Guinea Pigs; Histamine; Immunization; Inflammation; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Pulmonary Circulation; Receptors, Neurokinin-2; Vascular Resistance | 1993 |
Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig.
Topics: Amino Acid Sequence; Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Capsaicin; Guinea Pigs; Hypnotics and Sedatives; Injections, Intravenous; Male; Molecular Sequence Data; Neurokinin A; Piperidines; Receptors, Tachykinin; Serotonin | 1993 |
Mechanism of action of capsaicin on submucosal arterioles in the guinea pig ileum.
Topics: Animals; Arterioles; Capsaicin; Guinea Pigs; Ileum; Intestinal Mucosa; Parasympatholytics; Perfusion; Piperidines; Tetrodotoxin; Vasodilation; Vasodilator Agents | 1993 |
Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig.
Topics: Animals; Atropine; Autonomic Nervous System; Benzamides; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Receptors, Neurotransmitter; Receptors, Tachykinin | 1993 |
Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Female; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; Male; Neurokinin A; Neurons, Afferent; Piperidines | 1993 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Coloring Agents; Dose-Response Relationship, Drug; Evans Blue; Histamine Antagonists; Indoles; Inflammation; Isoindoles; Methysergide; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Neurokinin-1; Serotonin; Serotonin Antagonists; Substance P; Trachea | 1995 |
The involvement of calcitonin gene-related peptide (CGRP) and substance P in feline pial artery diameter responses evoked by capsaicin.
Topics: Anesthetics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cats; Cerebral Arteries; Female; Injections, Intravenous; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Trigeminal Nerve; Vasomotor System | 1995 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Electrocorticographic desynchronization after application of visceral and somatic noxious stimuli in urethane-anesthetized rats: effect of intrathecal administration of tachykinin (NK 1 or NK 2) receptor antagonists.
Topics: Acetylcholine; Administration, Topical; Anesthesia; Animals; Benzamides; Capsaicin; Cortical Synchronization; Electric Stimulation; Indoles; Injections, Spinal; Isoindoles; Lidocaine; Male; Perineum; Physalaemin; Piperidines; Rats; Rats, Wistar; Receptors, Tachykinin; Sensitivity and Specificity; Urethane; Urinary Bladder | 1996 |
Effect of T-kinin on microvascular permeability and its modulation by peptidases in rat airways.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Heart Rate; Male; Molecular Sequence Data; Neprilysin; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Hydrolases; Peptidyl-Dipeptidase A; Piperidines; Rats; Rats, Sprague-Dawley; Respiratory System; Tachykinins | 1995 |
[Effect of FRG-8813, a new histamine H2-receptor antagonist, on gastric mucus production in rats].
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Gastric Mucosa; Histamine H2 Antagonists; Mucus; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley | 1995 |
RP67580, a neurokinin1 receptor antagonist, decreased restraint stress-induced defecation in rat.
Topics: Analgesics; Animals; Benzamides; Capsaicin; Defecation; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Restraint, Physical; Stereoisomerism; Stress, Psychological; Substance P | 1995 |
Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons.
Topics: Animals; Capsaicin; Female; Injections, Intradermal; Macaca fascicularis; Male; Neural Inhibition; Neurons; Periaqueductal Gray; Physical Stimulation; Piperidines; Protein Kinase C; Spinothalamic Tracts; Tetradecanoylphorbol Acetate | 1996 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan | 1996 |
The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peristalsis; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex | 1995 |
Evidence for adrenergic and tachykinin activity in venom of the stonefish (Synanceja trachynis).
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fish Venoms; Ganglionic Blockers; Guinea Pigs; Heart Atria; Ileum; Injections, Intravenous; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-2; Tachykinins; Tetrodotoxin; Vas Deferens | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Evidence for the participation of glutamate in reflexes involving afferent, substance P-containing nerve fibres in the rat.
Topics: Animals; Blood Pressure; Body Temperature; Capillary Permeability; Capsaicin; Colchicine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Male; Mustard Plant; Nerve Fibers; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Sciatic Nerve; Stereoisomerism | 1996 |
Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Heart Rate; Male; Nasal Cavity; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Swine; Vasodilation | 1996 |
Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells.
Topics: Alkaloids; Animals; Benzodioxoles; Biotransformation; Calcium; Capsaicin; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Guaiacol; Ion Channels; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Tachyphylaxis; Trigeminal Ganglion | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.
Topics: Animals; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Release; Hypersensitivity; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Pyrrolidines; Receptors, Neurokinin-2; Respiration | 1996 |
The role of substance P in myocardial dysfunction during ischemia and reperfusion.
Topics: Analgesics; Animals; Capsaicin; Guinea Pigs; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Piperidines; Substance P; Ventricular Dysfunction, Left | 1996 |
Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi.
Topics: Adult; Benzamides; Bronchi; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Female; Humans; Male; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Piperidines; Tachykinins | 1997 |
Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation.
Topics: Adenoviruses, Human; Animals; Capillary Permeability; Capsaicin; Dexamethasone; Ficusin; Gene Transfer Techniques; Genetic Vectors; Glucocorticoids; Hot Temperature; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Photosensitizing Agents; Piperidines; Protein Denaturation; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Respiratory System; Substance P; Ultraviolet Rays | 1997 |
Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions.
Topics: Animals; Animals, Newborn; Capsaicin; Cerebral Cortex; Chymases; Denervation; Dura Mater; Enzyme-Linked Immunosorbent Assay; Histamine; Histamine Antagonists; Inflammation; Male; Mast Cells; Methylhistamines; Nerve Fibers; Neurons, Afferent; Nippostrongylus; Piperidines; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Serine Endopeptidases; Strongylida Infections | 1997 |
Perceived irritation during ingestion of capsaicin or piperine: comparison of trigeminal and non-trigeminal areas.
Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Chemoreceptor Cells; Female; Glossopharyngeal Nerve; Humans; Irritants; Male; Mouth; Perception; Pharynx; Piperidines; Polyunsaturated Alkamides; Tongue; Trigeminal Nerve | 1997 |
Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Animals; Capsaicin; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haplorhini; Hot Temperature; Injections, Intradermal; Isoquinolines; Microdialysis; Nerve Fibers; Neural Pathways; Physical Stimulation; Piperidines; Protein Kinase Inhibitors; Spinal Cord; Sulfonamides; Thalamus; Thionucleotides | 1997 |
Enhancement of rat trigeminal ganglion neuron responses to piperine in a low-pH environment and block by capsazepine.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Binding, Competitive; Capsaicin; Female; Hydrogen-Ion Concentration; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Protons; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 1997 |
MEN 11,420, a peptide tachykinin NK2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo.
Topics: Animals; Capsaicin; Hexamethonium; Male; Muscle Contraction; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Urinary Bladder | 1997 |
Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum.
Topics: Animals; Capsaicin; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1997 |
Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist.
Topics: Analgesics, Non-Narcotic; Animals; Brain; Capsaicin; Carrageenan; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Motor Activity; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetradecanoylphorbol Acetate | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor.
Topics: Animals; Biomechanical Phenomena; Capsaicin; Enzyme Activation; Enzyme Inhibitors; Macaca fascicularis; Nerve Fibers; Piperidines; Protein Kinase C; Spinothalamic Tracts; Temperature | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Insulin secretion by gastrin-releasing peptide in mice: ganglionic versus direct islet effect.
Topics: Animals; Blood Glucose; Capsaicin; Cells, Cultured; Female; Ganglia, Sympathetic; Gastrin-Releasing Peptide; Glucagon; Hexamethonium; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Pancreas; Piperidines; Receptor, Muscarinic M3; Receptors, Muscarinic | 1998 |
Selective blockade of substance P or neurokinin A receptors reduces the expression of c-fos in trigeminal subnucleus caudalis after corneal stimulation in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Autonomic Nervous System; Capsaicin; Cornea; Hormones; Immunohistochemistry; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Trigeminal Nucleus, Spinal | 1998 |
Neuropeptide regulation of proinflammatory cytokine responses.
Topics: Animals; Capsaicin; Cytokines; Endotoxins; Female; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Spleen; Tachykinins; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1998 |
Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter.
Topics: Animals; Capsaicin; Electric Stimulation; Esophagogastric Junction; Female; Ferrets; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetrodotoxin | 1998 |
Effects of endothelin-1 on capsaicin-induced nociception in mice.
Topics: Analgesia; Animals; Bosentan; Capsaicin; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hindlimb; Hyperalgesia; Male; Mice; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Serotonin; Sulfonamides; Viper Venoms | 1998 |
Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Capsaicin; Conjunctiva; Cornea; Dose-Response Relationship, Drug; Electrophysiology; Ethanol; Ganglionic Stimulants; Histamine; Irritants; Male; Mouth Mucosa; Mustard Plant; Neurons; Nicotine; Piperidines; Plant Extracts; Plant Oils; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reaction Time; Serotonin; Sodium Chloride; Solvents; Stimulation, Chemical; Tachyphylaxis; Tongue; Trigeminal Nuclei | 1998 |
Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.
Topics: Amino Acid Sequence; Animals; Atropine; Benzamides; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2 | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Male; Muscle, Skeletal; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 1998 |
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.
Topics: Animals; Capsaicin; Cell Line; Guinea Pigs; Humans; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Structure-Activity Relationship | 1998 |
Subthreshold concentration of endothelin-1-enhanced, capsaicin-induced bronchoconstriction in anaesthetized guinea-pigs.
Topics: Aerosols; Airway Resistance; Anesthesia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Guinea Pigs; Male; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Substance P | 1998 |
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Neurokinin B; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Female; Formaldehyde; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pain Measurement; Piperidines; Plants, Medicinal; Postural Balance; Reaction Time; Vas Deferens | 1999 |
Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.
Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Hypertension; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 1999 |
Local administration of delta9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Capsaicin; Dronabinol; Female; Macaca mulatta; Male; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.
Topics: Animals; Capsaicin; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Division; Concanavalin A; Female; Interleukin-2; Lymphocyte Activation; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Specific Pathogen-Free Organisms; Spleen; Substance P | 1999 |
Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors.
Topics: Anesthesia; Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Tidal Volume | 1999 |
Gastroprotective mechanism of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonistic activity.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsaicin; Central Nervous System Depressants; Ethanol; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Membrane Potentials; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1999 |
Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Capsaicin; Cimetidine; Denervation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Famotidine; Food; Indomethacin; Male; Nitroarginine; Piperidines; Pyloric Antrum; Pyridines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Wound Healing | 1999 |
Effect of lafutidine, a novel histamine H2-receptor antagonist, on monochloramine-induced gastric lesions in rats: role of capsaicin-sensitive sensory neurons.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Chloramines; Cimetidine; Gastric Mucosa; Histamine H2 Antagonists; Ischemia; Membrane Potentials; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stomach; Stomach Ulcer | 1999 |
Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Common Bile Duct; Electric Stimulation; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Physalaemin; Piperidines; Potassium Chloride; Pyridoxal Phosphate; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Tachykinins; Tetrodotoxin | 1999 |
Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins.
Topics: Acetylcholine; Air Pressure; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Nicotiana; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke; Tachykinins; Vagotomy | 1999 |
Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line.
Topics: Bronchi; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Transformed; Cytokines; Epithelial Cells; Gene Expression; Humans; Interleukin-6; Interleukin-8; Peptide Fragments; Piperidines; Protease Inhibitors; RNA, Messenger; Substance P; Thiorphan; Tumor Necrosis Factor-alpha | 1999 |
Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: relation to capsaicin-sensitive sensory neurons.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Capsaicin; Dose-Response Relationship, Drug; Duodenal Ulcer; Histamine H2 Antagonists; Indomethacin; Intestinal Mucosa; Male; Neurons, Afferent; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley | 2000 |
Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation.
Topics: Animals; Atrasentan; Capsaicin; Edema; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hyperalgesia; Male; Mice; Nociceptors; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Viper Venoms | 2000 |
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Physalaemin; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridoxal Phosphate; Receptors, Neurokinin-3; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2000 |
The role of sensorial neuropeptides in the edematogenic responses mediated by B(1) agonist des-Arg(9)-BK in rats pre-treated with LPS.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Edema; Histamine H1 Antagonists; Lipopolysaccharides; Male; Methysergide; Mianserin; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Pyrazoles; Pyridines; Pyrilamine; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptors, Bradykinin; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Serotonin Antagonists | 2000 |
Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs.
Topics: Animals; Benzhydryl Compounds; Benzilates; Capsaicin; Cholinergic Antagonists; Cresols; Dilatation; Dose-Response Relationship, Drug; Guinea Pigs; Male; Mandelic Acids; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Naphthyridines; Parasympatholytics; Phenylpropanolamine; Piperidines; Propiophenones; Receptors, Tachykinin; Reflex; Tolterodine Tartrate; Urinary Bladder; Urination | 2000 |
Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea.
Topics: Acetylcholine; Animals; Benzamides; Capsaicin; Choline; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Trachea | 2000 |
The anandamide transport inhibitor AM404 activates vanilloid receptors.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Endocannabinoids; Female; Hepatic Artery; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Oocytes; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant; Vasodilation; Xenopus | 2000 |
Role of neurokinin receptors in the behavioral effect of intravesical antigen infusion in guinea pig bladder.
Topics: Administration, Intravesical; Animals; Antigens; Behavior, Animal; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pelvic Pain; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Urinary Bladder | 2000 |
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2 | 2000 |
Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release.
Topics: Alkaloids; Animals; Benzodioxoles; Calibration; Capsaicin; Diterpenes; Electric Stimulation; Enzyme Inhibitors; Female; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Trachea | 1999 |
The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdomen; Animals; Animals, Newborn; Antiemetics; Behavior, Animal; Capsaicin; Cisplatin; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Motion Sickness; Nicotine; Piperidines; Proto-Oncogene Proteins c-fos; Serotonin Receptor Agonists; Shrews; Tropisetron; Vagotomy; Vomiting | 2000 |
Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung.
Topics: Animals; Benzimidazoles; Bronchoconstriction; Capsaicin; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Lung; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Receptors, Opioid; Sulfur Radioisotopes | 2000 |
Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Analgesics, Opioid; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Neurons, Afferent; Neuroprotective Agents; Oligopeptides; Pain; Pertussis Toxin; Piperidines; Protease Inhibitors; Purinergic Agonists; Thionucleosides; Time Factors; Virulence Factors, Bordetella | 2000 |
Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro.
Topics: Animals; Brunner Glands; Capsaicin; Carbachol; Choline O-Acetyltransferase; Cholinergic Agonists; Cholinergic Fibers; Dimethylphenylpiperazinium Iodide; Duodenum; Electric Stimulation; Female; Ganglia, Sympathetic; Guanethidine; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; Muscarinic Antagonists; Neural Pathways; Neurotransmitter Agents; Nicotinic Agonists; Nicotinic Antagonists; Piperidines; Submucous Plexus; Substance P; Sympatholytics; Tetrodotoxin; Vagotomy; Vagus Nerve | 2000 |
Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Chymases; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-1; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Serine Endopeptidases; Tachykinins; Thrombin; Trachea; Trypsin; Tryptases | 2000 |
Bidirectional control of airway responsiveness by endogenous cannabinoids.
Topics: Animals; Arachidonic Acids; Axons; Bronchi; Bronchial Spasm; Bronchoconstriction; Cannabinoids; Capsaicin; Cough; Endocannabinoids; Guinea Pigs; Lung; Muscle Contraction; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Capsaicin; Croton Oil; Dermatitis, Allergic Contact; Dermatitis, Irritant; Enzyme Inhibitors; Female; Glycopeptides; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Skin; Substance P | 2001 |
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Biological Transport; Calcium; Calcium Channel Blockers; Cannabinoids; Capsaicin; CHO Cells; Cricetinae; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Transfection; TRPV Cation Channels; Vas Deferens | 2001 |
Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries.
Topics: Animals; Arachidonic Acids; Benzoxazines; Biological Factors; Calcium Channel Blockers; Cannabinoids; Capsaicin; Electrophysiology; Endocannabinoids; Endothelium, Vascular; Membrane Potentials; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant; Vasodilator Agents | 2001 |
Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones.
Topics: Animals; Calcium; Cannabinoids; Capsaicin; Dronabinol; Ganglia, Spinal; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Effect of vanilloid drugs on gastrointestinal transit in mice.
Topics: Alkaloids; Animals; Arachidonic Acids; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Transit; Hexamethonium; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.
Topics: Adenosine Diphosphate; Animals; Benzofurans; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Electrophysiology; Male; Mesenteric Arteries; Neurons, Afferent; Nitroprusside; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission; Time Factors; Vasodilation; Vasodilator Agents | 2001 |
Mouse macrophages release a neutrophil chemotactic mediator following stimulation by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzamides; Calcium; Capsaicin; Chemotactic Factors; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Dexamethasone; Drug Stability; Enterotoxins; Glucocorticoids; Glucose; Indomethacin; Macrophages, Peritoneal; Magnesium; Male; Mice; Molecular Weight; Neutrophils; Piperidines; Receptors, Neurokinin-2; Thioglycolates | 2001 |
Tachykinins mediate slow excitatory postsynaptic transmission in guinea pig sphincter of Oddi ganglia.
Topics: Animals; Calcium; Capsaicin; Culture Techniques; Excitatory Postsynaptic Potentials; Female; Ganglia; Guinea Pigs; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Sphincter of Oddi; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 2001 |
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Pyrilamine; Quinoxalines; Rats; Rats, Wistar; Rimonabant; Signal Transduction; Stereoisomerism; Theophylline; Vasodilation | 2001 |
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins | 2001 |
Inhibitory activity of nociceptin/orphanin FQ on capsaicin-induced bronchoconstriction in the guinea-pig.
Topics: Animals; Benzimidazoles; Bronchoconstriction; Bronchoconstrictor Agents; Capsaicin; Drug Therapy, Combination; Guinea Pigs; Injections, Intravenous; Male; Naloxone; Neuropeptides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Plethysmography, Whole Body; Protease Inhibitors; Receptors, Opioid; Vasodilator Agents | 2001 |
Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats.
Topics: Animals; Behavior, Animal; Capillary Permeability; Capsaicin; Chlorpheniramine; Dose-Response Relationship, Drug; Glycopeptides; Histamine; Histamine H1 Antagonists; Indoles; Injections, Intradermal; Male; Mast Cells; Methysergide; Neurons, Afferent; Peptides; Piperidines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Skin; Substance P | 2001 |
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Capsaicin; Hyperalgesia; Male; Morpholines; Naphthalenes; Neurons, Afferent; Pain Measurement; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Influence of capsaicin cream in rats with peripheral neuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Benzamides; Capsaicin; Carrageenan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Isoindoles; Male; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Piperidines; Postoperative Period; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance Withdrawal Syndrome; Time Factors | 2001 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Indomethacin; Lipoxygenase; Muscle Contraction; Oxazepines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Thiorphan | 2001 |
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine | 2001 |
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Comparative effect of Phoneutria nigriventer spider venom and capsaicin on the rat paw oedema.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Edema; Female; Foot; Histamine H1 Antagonists; Indicators and Reagents; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Piperidines; Quinuclidines; Rats; Rats, Wistar; Spider Venoms | 2001 |
Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway.
Topics: Airway Resistance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Piperidines; Receptors, Neurokinin-2; Trachea | 2001 |
Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs.
Topics: Analysis of Variance; Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; In Situ Hybridization; Male; Neurons, Afferent; Piperidines; Protein Precursors; Radioimmunoassay; Random Allocation; Receptors, Neurokinin-2; Smoking; Tachykinins | 2001 |
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation | 2001 |
Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Barium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Receptors, Drug; Rimonabant; Sheep; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2001 |
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cell Division; Glioma; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 2001 |
Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice.
Topics: Administration, Topical; Animals; Bradykinin; Bradykinin Receptor Antagonists; Burns; Capsaicin; Cell Movement; Dermatitis; Edema; Hot Temperature; Injections, Intravenous; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Receptors, Neurokinin-1; Tachykinins; Time Factors | 2001 |
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Cations; Ditiocarb; Famotidine; Ion Channels; Male; Piperidines; Pyloric Antrum; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; Stomach Ulcer | 2001 |
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P | 2001 |
CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Mice; Nociceptors; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-1; Rimonabant; Spinal Cord; Substance P | 2002 |
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; Capsaicin; Carrageenan; Central Nervous System; CHO Cells; Cricetinae; Disease Models, Animal; Edema; Extravasation of Diagnostic and Therapeutic Materials; Gene Expression; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Mice; Neurogenic Inflammation; Pain; Pain Measurement; Piperidines; Proto-Oncogene Proteins c-fos; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Species Specificity; Spinal Cord; Transfection; Tritium | 2002 |
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Leukocytes; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pleura; Pleurisy; Quinuclidines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurokinin-1; Soybean Proteins; Spider Venoms; Trypsin Inhibitors | 2002 |
Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
Topics: Animals; Benzimidazoles; Capsaicin; Female; Heating; Macaca mulatta; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Piperidines; Receptors, Opioid; Tail | 2002 |
Relaxant effect of capsazepine in the isolated rat ileum.
Topics: Alkaloids; Animals; Benzodioxoles; Calcium Channels, L-Type; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2002 |
Sensitizing effects of lafutidine on CGRP-containing afferent nerves in the rat stomach.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Neurons, Afferent; Nitric Oxide; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stomach | 2002 |
Inhibition of human low density lipoprotein oxidation by active principles from spices.
Topics: Alkaloids; Allyl Compounds; Ascorbic Acid; Benzodioxoles; Butylated Hydroxyanisole; Capsaicin; Curcumin; Eugenol; Humans; In Vitro Techniques; Lipoproteins, LDL; Oxidation-Reduction; Piperidines; Polyunsaturated Alkamides; Quercetin; Spices; Sulfides | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Mice; Mice, Inbred Strains; Mice, Knockout; Morpholines; Multiple Sclerosis; Muscle Spasticity; Naphthalenes; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent.
Topics: Animals; Aorta; Arachidonic Acids; Cannabinoids; Capsaicin; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Gap Junctions; GTP-Binding Proteins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 2002 |
The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hindlimb; In Vitro Techniques; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Rimonabant; Skin | 2002 |
Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Allergens; Animals; Butanols; Capsaicin; Cats; Dogs; Edema; Ferrets; Gerbillinae; Guinea Pigs; Histamine; Kinetics; Malates; Mice; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Platelet Activating Factor; Rabbits; Receptors, Neurokinin-1; Salivation; Substance P; Time Factors | 2002 |
SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.
Topics: Acetamides; Administration, Oral; Animals; Bronchoconstriction; Capillary Permeability; Capsaicin; CHO Cells; Cough; Cricetinae; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Artery; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Vas Deferens | 2002 |
Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Castor Oil; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Intestinal Secretions; Intestine, Small; Male; Mice; Mice, Inbred ICR; Organ Size; Piperidines; Polyunsaturated Alkamides | 2002 |
Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers.
Topics: Animals; Axons; Benzoxazines; Capsaicin; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Male; Morpholines; Naphthalenes; Nerve Fibers; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Reflex, Monosynaptic; Synaptic Transmission | 2002 |
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Topics: Aerosols; Animals; Arachidonic Acids; Calcium; Camphanes; Capsaicin; Cells, Cultured; Consciousness; Cough; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Guinea Pigs; Male; Nodose Ganglion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.
Topics: Animals; Appetite Regulation; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Capsaicin; Denervation; Dose-Response Relationship, Drug; Drug Synergism; Eating; Endocannabinoids; Feeding Behavior; Gastric Mucosa; Hyperphagia; Injections, Intraperitoneal; Injections, Intraventricular; Intestine, Small; Male; Morpholines; Naphthalenes; Oleic Acid; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Satiety Response | 2002 |
Evidence for the involvement of a macrophage-derived chemotactic mediator in the neutrophil recruitment induced by staphylococcal enterotoxin B in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Capsaicin; Chemotaxis, Leukocyte; Cimetidine; Dexamethasone; Diterpenes; Enterotoxins; Enzyme Inhibitors; Ginkgolides; Hydroxamic Acids; Indomethacin; Interleukin-8; Lactones; Macrophages, Peritoneal; Male; Mice; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar | 2002 |
Effect of lafutidine, a histamine H2-receptor antagonist, on gastric mucosal blood flow and duodenal HCO3- secretion in rats: relation to capsaicin-sensitive afferent neurons.
Topics: Acetamides; Animals; Bicarbonates; Capsaicin; Cells, Cultured; Coloring Agents; Duodenum; Gastric Mucosa; Histamine H2 Antagonists; Male; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Regional Blood Flow; Ruthenium Red | 2002 |
Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Male; Neuropeptides; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Somatostatin; Substance P; Trachea | 2003 |
R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Trachea | 2003 |
Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats.
Topics: Acetamides; Analysis of Variance; Animals; Capsaicin; Drug Combinations; Drug Synergism; Gastric Mucosa; Histamine H2 Antagonists; Laser-Doppler Flowmetry; Liver; Liver Circulation; Male; Neurons, Afferent; Piperidines; Pyridines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Thyrotropin-Releasing Hormone | 2003 |
Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Male; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Flurbiprofen; Immunoassay; In Vitro Techniques; Phospholipases A; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord | 2003 |
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Neutral; Animals; Arachidonic Acids; Basal Ganglia; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Endocannabinoids; gamma-Aminobutyric Acid; Huntington Disease; Hyperkinesis; Male; Motor Activity; Nitro Compounds; Palmitates; Piperidines; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Endocannabinoids; Hypertension; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.
Topics: Animals; Base Sequence; Biphenyl Compounds; Capsaicin; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Gene Expression; Lipopolysaccharides; Liver Diseases; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; RNA, Messenger; Sequence Homology, Nucleic Acid; Time Factors; Transcriptional Activation | 2003 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
Substance P released from intrinsic airway neurons contributes to ozone-enhanced airway hyperresponsiveness in ferret trachea.
Topics: Animals; Capsaicin; Electric Stimulation; Female; Ferrets; Ganglia; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons; Ozone; Piperidines; Substance P; Trachea | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Cannabinoids; Capsaicin; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ganglia, Spinal; In Vitro Techniques; Male; Nerve Growth Factor; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2003 |
Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine.
Topics: Acetamides; Animals; Capsaicin; Catechols; Dose-Response Relationship, Drug; Fatty Alcohols; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurons; Piperidines; Pyridines | 2003 |
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
Topics: Animals; Camphanes; Cannabinoids; Capsaicin; Consciousness; Cough; Cyclohexanols; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypertonic Solutions; In Vitro Techniques; Male; Middle Aged; Neurons, Afferent; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Rimonabant; Vagus Nerve | 2003 |
Contribution of capsaicin-sensitive afferent nerves to rapid recovery from ethanol-induced gastric epithelial damage in rats.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capillary Permeability; Capsaicin; Edetic Acid; Ethanol; Gastric Mucosa; Male; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Stomach Ulcer | 2003 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neurons.
Topics: Acetamides; Animals; Capsaicin; Dose-Response Relationship, Drug; Esophagitis, Peptic; Histamine Antagonists; Male; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H2 | 2003 |
Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Antihypertensive Agents; Arachidonic Acids; Benzoxazines; Blood Pressure; Calcium Channel Blockers; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Ganglionic Blockers; Heart Rate; Hemodynamics; Hexamethonium; Injections, Spinal; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Spinal Cord; Urethane | 2003 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship, Drug; Flowers; Formaldehyde; Fruit; Hot Temperature; Indomethacin; Male; Mice; Pain; Phytotherapy; Piperidines; Plant Extracts | 2003 |
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Enteric Nervous System; Inflammation; Mice; Neurons, Afferent; Neuropeptides; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1 | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Cell Movement; Endocannabinoids; Hyperalgesia; Male; Nerve Growth Factor; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2003 |
Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro.
Topics: Amidohydrolases; Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Drug Interactions; Electric Stimulation; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Long-Term Potentiation; Male; Morpholines; Naphthalenes; Neurons; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Sleep | 2004 |
Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Endocannabinoids; Hypotension; Male; Neurons; Nitroprusside; Pain; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Trigeminal Caudal Nucleus; Vasodilation | 2004 |
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon.
Topics: Animals; Atropine; Benzamides; Capsaicin; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin | 2004 |
Individual differences in perception of bitterness from capsaicin, piperine and zingerone.
Topics: Adolescent; Adult; Alkaloids; Benzodioxoles; Capsaicin; Female; Guaiacol; Humans; Male; Middle Aged; Perception; Piperidines; Polyunsaturated Alkamides; Receptors, Cell Surface; Taste; Taste Buds | 2004 |
Multiple actions of anandamide on neonatal rat cultured sensory neurones.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Drug Synergism; Endocannabinoids; Fura-2; Ganglia, Spinal; Neurons, Afferent; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; TRPV Cation Channels | 2004 |
Mustard oil induces a transient receptor potential vanilloid 1 receptor-independent neurogenic inflammation and a non-neurogenic cellular inflammatory component in mice.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Ear; Edema; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neurokinin-1 Receptor Antagonists; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-1; Staining and Labeling; Time Factors; TRPV Cation Channels | 2004 |
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Atrophy; Autocrine Communication; Binding Sites; Capsaicin; Cell Death; Cell Division; Concanavalin A; Growth Substances; Male; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Thymus Gland; Up-Regulation | 2004 |
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Catechols; Diterpenes; Famotidine; Fatty Alcohols; Gastric Mucosa; Hydrochloric Acid; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Stomach Ulcer | 2004 |
Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Blood Pressure; Camphanes; Capsaicin; Decerebrate State; Disease Models, Animal; Electric Stimulation; Germany; Imidazoles; Infusions, Intravenous; Lipopolysaccharides; Male; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Shock, Septic; Solvents; Thiourea; Vagotomy; Vasomotor System; Vasopressins | 2004 |
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.
Topics: Animals; Avian Sarcoma Viruses; Capsaicin; Cell Line, Transformed; Cell Line, Tumor; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Fibroblasts; Genetic Vectors; Hindlimb; Hyperalgesia; Inflammation; Male; Mice; Morphine; Neoplasm Regression, Spontaneous; Neoplasm Transplantation; Nociceptors; Oligopeptides; Pain Measurement; Peptides, Cyclic; Piperidines; Rats; Reaction Time; Receptors, Endothelin | 2004 |
Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens.
Topics: Acetylcholine; Animals; Arachidonic Acids; Argentina; Capsaicin; Chile; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Estradiol; Estrogens; Female; Male; Mesentery; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Ovariectomy; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sex Characteristics; Time Factors; Vasodilation | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Calcium; Capsaicin; Cells, Cultured; Dopamine; Drug Interactions; Electrophysiology; Male; Membrane Potentials; Nerve Fibers; Pain Measurement; Physical Stimulation; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Sensory Thresholds; Spinal Cord | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Topics: Administration, Oral; Animals; Camphanes; Cannabidiol; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperalgesia; Inflammation; Italy; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Rimonabant; Time Factors | 2004 |
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Capsaicin; Cation Transport Proteins; CHO Cells; Cricetinae; Endothelium, Vascular; Gadolinium; Ganglia, Sympathetic; Guanethidine; Hydroxyeicosatetraenoic Acids; Ion Channels; Male; Mesenteric Arteries; Mice; Mice, Knockout; Models, Cardiovascular; Models, Neurological; Nerve Fibers, Unmyelinated; Nociceptors; Peptides, Cyclic; Piperidines; Pressure; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ruthenium Red; Sodium Channel Blockers; Splanchnic Circulation; Stress, Mechanical; Sympathectomy, Chemical; Tetrodotoxin; TRPV Cation Channels; Vascular Resistance; Vasoconstriction | 2004 |
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
Topics: Arachidonic Acids; Blood-Brain Barrier; Brain; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Adhesion Molecules; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Glycerides; Humans; Ion Channels; Microcirculation; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; TRPV Cation Channels | 2004 |
Protective effect of lafutidine, a novel histamine H2-receptor antagonist, on dextran sulfate sodium-induced colonic inflammation through capsaicin-sensitive afferent neurons in rats.
Topics: Acetamides; Animals; Capsaicin; Colitis, Ulcerative; Dextran Sulfate; Histamine H2 Antagonists; Intestinal Mucosa; Male; Neurons, Afferent; Peroxidase; Piperidines; Pyridines; Rats; Rats, Wistar | 2004 |
Lafutidine-induced increase in intracellular ca(2+) concentrations in PC12 and endothelial cells.
Topics: Acetamides; Animals; Calcium; Calcium Chloride; Capsaicin; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Imidazoles; Immunoblotting; Intracellular Fluid; PC12 Cells; Piperidines; Pyridines; Rats; Thapsigargin; Time Factors | 2005 |
AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Dose-Response Relationship, Drug; Endocannabinoids; Immunohistochemistry; Indoles; Male; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2005 |
Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats.
Topics: Animals; Capsaicin; DNA; Gastric Mucosa; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Immersion; Interleukin-1; Male; Neurons, Afferent; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Regional Blood Flow; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 2005 |
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydramine; Diterpenes; Domperidone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Indomethacin; Malates; Methysergide; Metoclopramide; Migraine Disorders; Ondansetron; Piperidines; Ruthenium Red; Scopolamine; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews; Sumatriptan; Time Factors; Tropanes; Vomiting | 2005 |
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1).
Topics: Alkaloids; Benzodioxoles; Capsaicin; Cell Line; Humans; Hydrogen-Ion Concentration; Patch-Clamp Techniques; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Receptors, Drug; Ruthenium Red; Structure-Activity Relationship | 2005 |
CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.
Topics: Animals; Bradykinin; Calcium; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dose-Response Relationship, Drug; Dronabinol; Enzyme Induction; Enzyme Inhibitors; Ganglia, Spinal; Isoquinolines; Male; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Substance P; Sulfonamides; Time Factors | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cannabidiol; Capsaicin; Drug Interactions; Ear, External; Gastrointestinal Motility; Inflammation; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motor Activity; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2005 |
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; In Vitro Techniques; Isometric Contraction; Male; Mice; Morpholines; Naloxone; Naphthalenes; Phenylephrine; Piperidines; Pyrazoles; Rimonabant; Ruthenium Red; TRPV Cation Channels; Vas Deferens; Yohimbine | 2005 |
Sensory peptide neurotransmitters mediating mucosal and distension evoked neural vasodilator reflexes in guinea pig ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; Hexamethonium; Ileum; Intestinal Mucosa; Neurons; Neurotransmitter Agents; Nifedipine; Piperidines; Signal Transduction; Tachykinins; Vasodilation | 2005 |
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
Topics: Action Potentials; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Camphanes; Cannabinoids; Capsaicin; Cells, Cultured; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Neural Inhibition; Neurons; Pain Measurement; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord Diseases; Touch | 2005 |
TRPV1 activation results in disruption of the blood-brain barrier in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Capillary Permeability; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Microspheres; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Starch; Substance P; Tetrazoles; Time Factors; TRPV Cation Channels | 2005 |
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.
Topics: Anilides; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Capsaicin; Cinnamates; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitroarginine; Perfusion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; RNA, Messenger; TRPV Cation Channels; Vasodilation | 2005 |
Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
Topics: Amides; Animals; Arachidonic Acids; Bronchi; Bronchoconstriction; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Agonists; Capsaicin; Electric Stimulation; Endocannabinoids; Ethanolamines; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Organ Culture Techniques; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Substance P | 2005 |
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Carrier Proteins; Cytosol; Endocannabinoids; Male; Medulla Oblongata; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Phospholipases A; Phospholipases A2; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stress, Psychological; TRPV Cation Channels | 2005 |
VR1-mediated depressor effects during high-salt intake: role of anandamide.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Endocannabinoids; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Sodium, Dietary; Time Factors; TRPV Cation Channels | 2005 |
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors.
Topics: Anilides; Animals; Benzoxazines; Body Temperature; Calcium Channel Blockers; Camphanes; Capsaicin; Cinnamates; Hypothermia; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; TRPV Cation Channels | 2005 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Charybdotoxin; Diclofenac; Dimethyl Sulfoxide; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitroarginine; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; rho-Associated Kinases; Tetraethylammonium; Vasodilator Agents | 2006 |
Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.
Topics: Animals; Avoidance Learning; Brain Ischemia; Cannabinoid Receptor Antagonists; Capsaicin; Electroencephalography; Gerbillinae; Male; Motor Activity; Neuroprotective Agents; Piperidines; Pyrazoles; Rimonabant; TRPV Cation Channels | 2006 |
Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats.
Topics: Amidohydrolases; Anilides; Animals; Arachidonic Acids; Body Temperature; Capsaicin; Cinnamates; Endocannabinoids; Hypothermia; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; TRPV Cation Channels | 2006 |
Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Calcium; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Histamine H2 Antagonists; Humans; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Piperidines; Prostaglandins; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Stomach; Stomach Diseases; TRPV Cation Channels | 2006 |
The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons.
Topics: Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Gene Expression Regulation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Phosphorylation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; STAT3 Transcription Factor; TRPV Cation Channels | 2006 |
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.
Topics: Analysis of Variance; Animals; Benzothiazoles; Brain; Capsaicin; Drug Synergism; Ganglia, Spinal; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Touch | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Drug Administration Schedule; Endocannabinoids; Ganglia, Spinal; Hot Temperature; Immunologic Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid-Related Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2006 |
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Topics: Animals; Arachidonic Acids; Bile Ducts; Blood Flow Velocity; Blood Pressure; Blotting, Western; Capsaicin; Cardiac Output; Disease Models, Animal; Endocannabinoids; Hyperemia; Indoles; Liver Circulation; Liver Cirrhosis, Biliary; Male; Mesenteric Artery, Superior; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Circulation; Time Factors; TRPV Cation Channels; Vascular Resistance; Vasodilation; Vasodilator Agents | 2006 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Time Factors; Vibration | 2007 |
Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.
Topics: Alkaloids; Anilides; Animals; Benzodioxoles; Capsaicin; Cinnamates; Cricetinae; Enzyme Inhibitors; Esophagus; Female; Male; Mesocricetus; Mice; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Tachykinin; Species Specificity; TRPV Cation Channels; Tryptophan; Vagus Nerve | 2007 |
NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla.
Topics: Animals; Capsaicin; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; Immunohistochemistry; Iontophoresis; Male; Medulla Oblongata; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2007 |
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Disease Models, Animal; Endocannabinoids; Famotidine; Ganglia, Spinal; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Neurons, Afferent; Neutrophil Activation; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Wistar; Restraint, Physical; Stomach Ulcer; Stress, Psychological | 2007 |
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Calcium; Capsaicin; Carbamates; Cells, Cultured; Dopamine; Drug Interactions; Endocannabinoids; Fura-2; Furans; Ganglia, Spinal; Male; Membrane Potentials; Membrane Transport Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2006 |
TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Female; Indicators and Reagents; Mechanotransduction, Cellular; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pressure; Rats; Rats, Wistar; Ruthenium Red; Stress, Mechanical; TRPV Cation Channels; Urinary Bladder | 2007 |
Pharmacological characterisation of capsaicin-induced relaxations in human and porcine isolated arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Cyclic AMP; Dipeptides; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Chloride; Protein Kinase Inhibitors; Quinazolines; Swine; Vasodilation | 2007 |
Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats.
Topics: Alkaloids; Ammonia; Animals; Armoracia; Aspirin; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Ethanol; Food Preservatives; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Isothiocyanates; Male; NG-Nitroarginine Methyl Ester; Omeprazole; Piperidines; Polyunsaturated Alkamides; Prostaglandins; Rats; Rats, Sprague-Dawley; Ruthenium Red; Structure-Activity Relationship | 2007 |
Temporal interactions between oral irritants: piperine, zingerone, and capsaicin.
Topics: Administration, Oral; Alkaloids; Benzodioxoles; Capsaicin; Guaiacol; Humans; Irritants; Piperidines; Polyunsaturated Alkamides | 2007 |
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
Topics: Acrylamides; Animals; Antiemetics; Arachidonic Acids; Area Postrema; Autonomic Pathways; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoids; Capsaicin; Dopamine; Emetics; Endocannabinoids; Ferrets; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Solitary Nucleus; TRPV Cation Channels; Vagus Nerve; Vomiting | 2007 |
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels | 2007 |
Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro.
Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Capsaicin; Carrier Proteins; Curcumin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Heme-Binding Proteins; Hemeproteins; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2006 |
Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Curcumin; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Micelles; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spices | 2007 |
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels | 2007 |
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation | 2007 |
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Methoxamine; Neurons, Afferent; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ruthenium Red; Time Factors; Vasodilation | 2007 |
Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dopamine; Male; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Rimonabant; Sodium Chloride, Dietary; TRPV Cation Channels | 2007 |
Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries.
Topics: Acetamides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Drug Synergism; Electric Stimulation; Male; Mesenteric Arteries; Peripheral Nervous System; Piperidines; Pyridines; Rats; Rats, Wistar; Ruthenium Red; TRPV Cation Channels; Vasodilation | 2008 |
Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Cannabidiol; Capsaicin; Gastric Emptying; Gastrointestinal Motility; Intestine, Small; Lipopolysaccharides; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory System Agents; Sepsis | 2008 |
Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.
Topics: Animals; Bronchoalveolar Lavage; Capsaicin; Cell Survival; Female; Gene Expression Regulation, Enzymologic; Lung; Macrophages, Alveolar; Matrix Metalloproteinase 12; Mice; Piperidines; Pulmonary Emphysema; Receptors, Neurokinin-1; RNA, Messenger; Smoking; Substance P; Up-Regulation | 2008 |
Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.
Topics: Animals; Capsaicin; Cetirizine; Disease Models, Animal; Female; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Imidazoles; Mice; Mice, Inbred BALB C; Ovalbumin; Piperidines; Pyrrolidines; Receptors, Histamine H3; Rhinitis, Allergic, Perennial; Substance P; Thiourea | 2008 |
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Brain; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cinnamates; Diazepam; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2009 |
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
Topics: Acetamides; Animals; Antimetabolites, Antineoplastic; Capsaicin; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Epithelial Cells; Fluorouracil; Gastric Mucosa; Histamine H2 Antagonists; Hydrochloric Acid; Male; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sensory System Agents; Stomach Diseases; Wound Healing | 2009 |
TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Muscle, Smooth; Neurons, Afferent; Pelvic Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; TRPV Cation Channels; Uterus | 2008 |
Discovery of piperidine carboxamide TRPV1 antagonists.
Topics: Amides; Benzoxazines; Capsaicin; Carrier Proteins; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; Piperidines; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; TRPV Cation Channels | 2008 |
Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Arachidonic Acids; Behavior, Animal; Cannabidiol; Capsaicin; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Injections, Intraventricular; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; TRPV Cation Channels | 2008 |
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Galanin; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Narcotics; Nerve Fibers, Unmyelinated; Neuroblastoma; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical; Sulfonamides; TRPV Cation Channels | 2008 |
Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.
Topics: Administration, Topical; Animals; Antipruritics; Capillary Leak Syndrome; Capsaicin; Cell Degranulation; Disinfectants; Dose-Response Relationship, Drug; Formaldehyde; Hydrocarbons, Aromatic; Ketotifen; Male; Mast Cells; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Regional Blood Flow; Skin | 2009 |
Galanin modulates vagally induced contractions in the mouse oesophagus.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Esophagus; Female; Galanin; Indoles; Male; Mice; Muscle Contraction; NG-Nitroarginine Methyl Ester; Phenanthrolines; Piperidines; Polyunsaturated Alkamides; Receptors, Galanin; Sensory System Agents; Substance P; Vagus Nerve | 2009 |
Inhibitory effect of quercetin on rat trachea contractility in vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Benzamides; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Piperidines; Propranolol; Quercetin; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Trachea | 2009 |
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Topics: Animals; Binding Sites; Capsaicin; Combinatorial Chemistry Techniques; Cough; Disease Models, Animal; Drug Design; Guinea Pigs; Molecular Structure; Nociceptin Receptor; Piperidines; Receptors, Opioid; Spiro Compounds; Structure-Activity Relationship | 2009 |
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Topics: Animals; Ankyrins; Benzamides; Calcium Channels; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Male; Mustard Plant; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sciatic Nerve; Sensory Receptor Cells; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
Topics: Alfentanil; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Hot Temperature; Imidazoles; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Pain; Piperidines; Pruritus; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement, Psychology; Respiratory Insufficiency; Spiro Compounds | 2009 |
Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Disease Models, Animal; Drug Combinations; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Hot Temperature; Humidity; Hyperthermia, Induced; Hyperventilation; Male; Neurons, Afferent; Piperidines; Receptors, Tachykinin; Specific Pathogen-Free Organisms; TRPV Cation Channels; Tryptophan | 2009 |
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Capsaicin; Efferent Pathways; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Pyridazines; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Tetrodotoxin; Vagus Nerve | 2009 |
Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].
Topics: Analgesics; Animals; Capsaicin; Chromatography, High Pressure Liquid; Humans; Ligands; Mice; Microsomes, Liver; Pain; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor | 2009 |
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.
Topics: Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hindlimb; Hyperalgesia; Male; Oligopeptides; Pain Measurement; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sensory System Agents; Temperature; TRPV Cation Channels | 2009 |
Cannabinoid CB(1) receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca(2+) influx in an in vitro model of diabetic neuropathy.
Topics: Animals; Calcium; Capsaicin; Diabetic Neuropathies; Dose-Response Relationship, Drug; Dronabinol; Glucose; Hyperglycemia; Indoles; Nerve Growth Factor; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Sensory System Agents | 2009 |
Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis.
Topics: Acrolein; Adenosine Diphosphate; Alkaloids; Allyl Compounds; Arachidonic Acid; Benzodioxoles; Calcimycin; Capsaicin; Collagen Type III; Curcumin; Eugenol; Humans; Malondialdehyde; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polyunsaturated Alkamides; Quercetin; Spices; Sulfides; Thromboxanes | 2009 |
N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors.
Topics: Adenosine; Animals; Arachidonic Acids; Capsaicin; Dopamine; Hemodynamics; Male; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Respiration, Artificial; Respiratory Mechanics; TRPV Cation Channels; Vagus Nerve | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Capsaicin; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Epilepsy; GABA Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Serotonin; TRPV Cation Channels | 2009 |
Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Neurons; Neuropeptides; Pain; Pain Measurement; Piperidines; Receptor, Parathyroid Hormone, Type 2; Reflex; Sciatica; Signal Transduction; Time Factors; TRPV Cation Channels | 2010 |
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.
Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels | 2010 |
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines | 2010 |
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Topics: Animals; Capsaicin; Electric Stimulation; GABA-B Receptor Antagonists; Injections, Spinal; Male; Morpholines; Neurons; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; Substance P; TRPV Cation Channels | 2010 |
TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.
Topics: Analysis of Variance; Angiotensin II; Anilides; Animals; Capsaicin; Chelating Agents; Cinnamates; Diuretics, Osmotic; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Piperidines; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Supraoptic Nucleus; TRPV Cation Channels; Vasoconstrictor Agents | 2010 |
Opposing effects of cannabinoids and vanilloids on evoked quantal release at the frog neuromuscular junction.
Topics: Acetylcholine; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Pyrazoles; Rana catesbeiana; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2010 |
Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats.
Topics: Alkaloids; Animals; Benzodioxoles; Biological Availability; Capsaicin; Capsicum; Cell Membrane; Cholesterol; Diet; Enterocytes; Enzymes; Gastrointestinal Agents; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lipid Metabolism; Magnoliopsida; Male; Membrane Fluidity; Microscopy, Electron, Scanning; Microvilli; Phospholipids; Piper nigrum; Piperidines; Plant Preparations; Polyunsaturated Alkamides; Protein Conformation; Rats; Rats, Wistar; Spices; Zingiber officinale | 2010 |
In vitro TRPV1 activity of piperine derived amides.
Topics: Alkaloids; Amides; Benzodioxoles; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Spectrometry, Fluorescence; TRPV Cation Channels | 2010 |
Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Capsaicin; Capsicum; Catalase; Cytoprotection; Diet; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Gastrointestinal Diseases; Glutathione Reductase; Glutathione Transferase; Glycoproteins; Intestinal Mucosa; Male; Mucus; Oxidative Stress; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spices; Superoxide Dismutase; Zingiber officinale | 2010 |
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzodioxoles; Biological Transport; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Endocannabinoids; Male; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents | 2010 |
Effect of intraperitoneal injection of curcumin on food intake in a goldfish model.
Topics: Alkaloids; Animals; Appetite Depressants; Appetite Regulation; Benzodioxoles; Capsaicin; Corticotropin-Releasing Hormone; Curcumin; Eating; Enzyme Inhibitors; Feeding Behavior; Goldfish; Hormone Antagonists; Humans; Injections, Intraperitoneal; Molecular Structure; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Receptors, Corticotropin-Releasing Hormone; Sensory System Agents; Triterpenes; Ursolic Acid | 2011 |
Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats.
Topics: Administration, Oral; Alkaloids; Animals; Benzodioxoles; Biological Availability; Capsaicin; Chromatography, High Pressure Liquid; Curcumin; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Tissue Distribution | 2010 |
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.
Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Lipid Metabolism; Male; Neurons, Afferent; Pain; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sensory Receptor Cells; Solubility; TRPV Cation Channels; Urea | 2010 |
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Capsaicin; Cimetidine; Disease Models, Animal; Enterobacteriaceae; Famotidine; Histamine H2 Antagonists; Intestinal Mucosa; Intestine, Small; Male; Mucin-2; Nitric Oxide Synthase Type II; Omeprazole; Peptic Ulcer; Peroxidase; Phenylpropionates; Piperidines; Proton Pump Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensory Receptor Cells | 2010 |
Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity.
Topics: Animals; Aorta, Thoracic; Arachidonic Acids; Caffeine; Capsaicin; Chloride Channels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Vasodilation | 2010 |
Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.
Topics: Benzoxazines; Blotting, Western; Capsaicin; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Pyrazoles; Quinazolines; Receptor, Cannabinoid, CB1; Transcriptional Activation; TRPV Cation Channels; Tyrphostins | 2010 |
Lafutidine, a protective H₂ receptor antagonist, enhances mucosal defense in rat esophagus.
Topics: Acetamides; Animals; Capsaicin; Esophagus; Histamine H2 Antagonists; Laser-Doppler Flowmetry; Male; Mucous Membrane; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2010 |
Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon.
Topics: Animals; Atropine; Bicarbonates; Bumetanide; Capsaicin; Chlorides; Colon; Dioxanes; Enteroendocrine Cells; Fatty Acids, Nonesterified; Granisetron; Guinea Pigs; Hexamethonium; Intestinal Mucosa; Male; omega-Conotoxin GVIA; Piperidines; Potassium; Propionates; Pyridoxal Phosphate; Receptors, G-Protein-Coupled; Serous Membrane; Suramin; Tetrodotoxin | 2011 |
Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Culture Techniques; Drug Interactions; Endocannabinoids; Glycerides; Hippocampus; Monoacylglycerol Lipases; Nerve Degeneration; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2011 |
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Body Temperature Regulation; Brain; Camphanes; Capsaicin; Disease Models, Animal; Diterpenes; Endocannabinoids; Female; Hypothermia; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Lipopolysaccharides; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sulfonamides; Time Factors; TRPV Cation Channels | 2011 |
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Hyperalgesia; Immunohistochemistry; Male; Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sumatriptan; Trigeminal Caudal Nucleus; Tryptamines | 2011 |
TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Excitatory Amino Acid Agents; Glutamates; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission; TRPV Cation Channels | 2011 |
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Capsaicin; Depression; Dopamine; Endocannabinoids; Hindlimb Suspension; Ligands; Male; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming; TRPV Cation Channels | 2011 |
Fat digestion and absorption in spice-pretreated rats.
Topics: Adiposity; Alkaloids; Animals; Benzodioxoles; Bile; Bile Acids and Salts; Capsaicin; Curcumin; Diet, High-Fat; Dietary Fats; Digestion; Hydrolases; India; Intestinal Absorption; Lipid Metabolism; Liver; Male; Pancreas; Piperidines; Polyunsaturated Alkamides; Rats, Wistar; Rhizome; Spices; Up-Regulation; Zingiber officinale | 2012 |
Opposing roles for cannabinoid receptor type-1 (CB₁) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Topics: Anilides; Animals; Arachidonic Acids; Capsaicin; Cinnamates; Drug Interactions; Electric Stimulation; Male; Microinjections; Panic; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
In vitro and in vivo pharmacological characterisation of the potent and selective vasopressin V(1A) receptor antagonist 4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl-(3,5-difluoro-phenyl) methanone (PF-00738245)
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Aorta; Arginine Vasopressin; Blood Circulation; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Dogs; Female; Humans; Male; Models, Biological; Myometrium; Piperidines; Rats; Receptors, Oxytocin; Receptors, Vasopressin; Substrate Specificity; Triazoles | 2011 |
Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Hyperalgesia; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Pain Threshold; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sensory System Agents | 2012 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones | 2012 |
Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries.
Topics: Acetamides; Animals; Benzoquinones; Capsaicin; Endothelium, Vascular; Heptanoic Acids; Histamine; Indomethacin; Male; Mesenteric Arteries; Methoxamine; Piperidines; Procaine; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Histamine H2; Ruthenium Red; Tetrodotoxin; Thromboxane A2; TRPV Cation Channels; Vasoconstriction; Vasodilation | 2012 |
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation | 2012 |
The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Behavior, Animal; Capsaicin; Endocannabinoids; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Enhanced intestinal uptake of iron, zinc and calcium in rats fed pungent spice principles--piperine, capsaicin and ginger (Zingiber officinale).
Topics: Alkaloids; Animals; Benzodioxoles; Calcium; Capsaicin; Intestinal Absorption; Intestinal Mucosa; Intestines; Iron; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Zinc; Zingiber officinale | 2013 |
Release of CGRP from mouse brainstem slices indicates central inhibitory effect of triptans and kynurenate.
Topics: Animals; Brain Stem; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Organ Culture Techniques; Piperidines; Rats, Sprague-Dawley; Tryptamines | 2014 |
Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Interpersonal Relations; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Rimonabant; Schizophrenia; Schizophrenic Psychology; TRPV Cation Channels | 2014 |
Pharmacodynamics of TRPV1 agonists in a bioassay using human PC-3 cells.
Topics: Alkaloids; Apoptosis; Benzodioxoles; Biological Assay; Capsaicin; Cell Line, Tumor; Cell Survival; Humans; Male; Metabolic Clearance Rate; Piperidines; Polyunsaturated Alkamides; Prostatic Neoplasms; TRPV Cation Channels | 2014 |
Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Capsaicin; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; Hot Temperature; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; TRPV Cation Channels | 2014 |
Z944: a first in class T-type calcium channel modulator for the treatment of pain.
Topics: Acetamides; Administration, Oral; Benzamides; Calcium Channel Blockers; Capsaicin; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Lasers; Male; Pain; Piperidines; Time Factors | 2014 |
Anxiogenic-like effects induced by hemopressin in rats.
Topics: Anilides; Animals; Anxiety; Brain; Capsaicin; Cinnamates; Hemoglobins; Injections, Intraventricular; Male; Maze Learning; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Wistar | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Contribution of sensory nerves to LPS-induced hyperresponsiveness of human isolated bronchi.
Topics: Anilides; Bronchi; Bronchial Hyperreactivity; Capsaicin; Cinnamates; Electric Stimulation; Female; Humans; Indoles; Lipopolysaccharides; Male; Middle Aged; Muscle Contraction; Neprilysin; Neurokinin A; Piperidines; Sensory Receptor Cells; TRPV Cation Channels; Up-Regulation | 2015 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid | 2015 |
Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils.
Topics: Alkaloids; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Benzodioxoles; Capsaicin; Chemoprevention; Colony Count, Microbial; Diet Therapy; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Piperidines; Polyunsaturated Alkamides; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Stomach | 2016 |
High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs.
Topics: Acetanilides; Alkaloids; Animals; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Piperidines; Polyunsaturated Alkamides; Purines; Pyrazines; Pyridines; Trachea; TRPV Cation Channels; Urinary Bladder | 2015 |
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Dorsolateral periaqueductal gray matter CB1 and TRPV1 receptors exert opposite modulation on expression of contextual fear conditioning.
Topics: Animals; Capsaicin; Conditioning, Classical; Fear; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Soluble Guanylyl Cyclase; TRPV Cation Channels | 2016 |
Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.
Topics: Adult; Alkaloids; Benzodioxoles; Capsaicin; Ethanol; Female; Genetic Variation; Genotype; Humans; Male; Piperidines; Polymorphism, Single Nucleotide; Polyunsaturated Alkamides; Receptors, G-Protein-Coupled; Taste; Tongue | 2016 |
TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch.
Topics: Acetanilides; Acrylamides; Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Histamine Agonists; Imidazoles; Mice; Neurons; Piperidines; Pruritus; Purines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; TRPV Cation Channels; Type C Phospholipases | 2016 |
Involvement of TRPV1 in the Olfactory Bulb in Rimonabant-Induced Olfactory Discrimination Deficit.
Topics: Animals; Capsaicin; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smell; TRPV Cation Channels | 2016 |
Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation.
Topics: Cannabinoid Receptor Antagonists; Capsaicin; Cell Death; Cell Line, Tumor; Hematologic Neoplasms; Humans; Indoles; Oxazines; Piperidines; Pyrazoles; TRPV Cation Channels; Xanthenes | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2.
Topics: Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Capsaicin; Cells, Cultured; Ceramides; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Partial Thromboplastin Time; Phosphorylation; Piperidines; Pyrazoles; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Thromboplastin; TRPV Cation Channels | 2016 |
Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities.
Topics: Alkaloids; Benzodioxoles; Capsaicin; Curcumin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Recombinant Proteins; Spices | 2017 |
Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain.
Topics: Animals; Capsaicin; Cell-Penetrating Peptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Inflammation; Lipopeptides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Pain Threshold; Piperidines; Protein Kinase C; Rats; Rats, Long-Evans; Sex Characteristics; Spinal Cord | 2016 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla.
Topics: Animals; Capsaicin; Catheters, Indwelling; Central Nervous System Sensitization; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microelectrodes; Neurokinin-1 Receptor Antagonists; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Touch | 2017 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cerebral Cortex; Choice Behavior; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2018 |
Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport; Capsaicin; Catechols; Doxorubicin; Fatty Alcohols; Mice; Phytochemicals; Piperidines; Polyunsaturated Alkamides; Tissue Distribution | 2018 |
Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport; Caco-2 Cells; Capsaicin; Capsicum; Cell Line, Tumor; Doxorubicin; Drug Combinations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fluoresceins; Gene Expression; HCT116 Cells; Humans; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rhodamine 123 | 2018 |
Sinergism between alkaloids piperine and capsaicin with meglumine antimoniate against Leishmania infantum.
Topics: Alkaloids; Antiprotozoal Agents; Benzodioxoles; Capsaicin; Chromatography, High Pressure Liquid; Drug Synergism; Inhibitory Concentration 50; Leishmania infantum; Leishmaniasis, Visceral; Magnetic Resonance Spectroscopy; Meglumine; Meglumine Antimoniate; Organometallic Compounds; Piperidines; Polyunsaturated Alkamides; Spectrophotometry, Ultraviolet | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels | 2018 |
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Ganglia, Spinal; Hyperalgesia; Lysergic Acid Diethylamide; Male; Maze Learning; Neuralgia; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Swimming | 2019 |
Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti.
Topics: Alkaloids; Animals; Anthelmintics; Benzodioxoles; Biological Products; Brugia malayi; Capsaicin; Catalytic Domain; Curcumin; Drug Evaluation, Preclinical; Glutathione Transferase; Molecular Docking Simulation; Piperidines; Polyunsaturated Alkamides; Strychnine; Wuchereria bancrofti | 2018 |
A distinct structural mechanism underlies TRPV1 activation by piperine.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Hydrogen Bonding; Ion Channel Gating; Mice; Mutation; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; TRPV Cation Channels | 2019 |
Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Capsaicin; Drug Delivery Systems; Nasal Mucosa; Pharmaceutical Vehicles; Piperidines; Polyunsaturated Alkamides; Sheep | 2019 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
Comparative immunohistological study on using capsaicin, piperine, and okadaic acid for the transepithelial passage of the inactivated viral and bacterial vaccines in fish.
Topics: Adjuvants, Immunologic; Administration, Oral; Alkaloids; Animals; Bacterial Vaccines; Benzodioxoles; Biological Transport; Capsaicin; Fish Diseases; Okadaic Acid; Piperidines; Polyunsaturated Alkamides; Sea Bream; Viral Vaccines | 2020 |
Inhibitory effect of
Topics: Aflatoxins; Alkaloids; Antifungal Agents; Aspergillus; Benzodioxoles; Biosynthetic Pathways; Capsaicin; Capsicum; DNA-Binding Proteins; Fruit; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Transcription Factors | 2020 |
Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Capsaicin; Disease Models, Animal; Dopaminergic Neurons; Humans; Indoles; Mice; Mice, Inbred C57BL; Neurogenic Inflammation; Neuroglia; Neuroprotection; Parkinson Disease; Piperidines; Pyrazoles; Receptor Cross-Talk; Receptors, Cannabinoid; Substantia Nigra; TRPV Cation Channels | 2020 |
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels | 2021 |
Cytogenotoxicity and protective effect of piperine and capsaicin on meristematic cells of Allium cepa L.
Topics: Alkaloids; Benzodioxoles; Capsaicin; DNA Damage; Onions; Piperidines; Plant Roots; Polyunsaturated Alkamides | 2021 |
Turmeric, red pepper, and black pepper affect carotenoids solubilized micelles properties and bioaccessibility: Capsaicin/piperine improves and curcumin inhibits carotenoids uptake and transport in Caco-2 cells.
Topics: Alkaloids; Benzodioxoles; Biological Availability; Caco-2 Cells; Capsaicin; Capsicum; Carotenoids; Curcuma; Curcumin; Humans; Micelles; Piper nigrum; Piperidines; Polyunsaturated Alkamides | 2021 |
A Comparative Study on the Effect of Acute Pharyngeal Stimulation with TRP Agonists on the Biomechanics and Neurophysiology of Swallow Response in Patients with Oropharyngeal Dysphagia.
Topics: Acrolein; Acyclic Monoterpenes; Alkaloids; Benzodioxoles; Biomechanical Phenomena; Capsaicin; Deglutition; Deglutition Disorders; Humans; Menthol; Piperidines; Polyunsaturated Alkamides; Retrospective Studies; Zinc | 2022 |