capsaicin has been researched along with naloxone in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (17.48) | 18.7374 |
| 1990's | 53 (37.06) | 18.2507 |
| 2000's | 38 (26.57) | 29.6817 |
| 2010's | 24 (16.78) | 24.3611 |
| 2020's | 3 (2.10) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Ando, R; Kisara, K; Onodera, K; Shima, K | 1 |
| Kamei, J; Kasuya, Y; Katsuma, K | 1 |
| Ellis, JL; Undem, BJ | 1 |
| Green, PG; Levine, JD | 1 |
| Esplugues, JV; Moncada, S; Whittle, BJ | 1 |
| Campbell, EA; Perkins, MN | 1 |
| Barthó, L; Ernst, R; Faulstroh, K; Pethö, G; Pierau, FK; Sann, H | 1 |
| Lemieux, M; Rioux, F | 1 |
| Nakayama, S; Yamasato, T | 1 |
| Kangrga, I; Randić, M | 1 |
| Kwok, YN; McIntosh, CH | 1 |
| Matsuo, S; Nakayama, S; Neya, T | 1 |
| Helme, RD; Khalil, Z | 1 |
| Braun, KP; Goodman, M; Jang, JD; Nishiuchi, Y; Ro, SG; Yaksh, TL | 1 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Barthó, L; Ernst, R; Pierau, FK; Sann, H | 1 |
| Li, R; Yu, YX | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 1 |
| Baker, M; Endoh, K; Leung, FW | 1 |
| Barbanti, G; Giachetti, A; Maggi, CA; Patacchini, R; Renzi, D; Santicioli, P; Theodorsson, E; Turini, D | 1 |
| Cheng, CL; de Groat, WC; Hisamitsu, T; Kawatani, M; Ma, CP; Roppolo, JR; Steers, W; Thor, K | 1 |
| Esplugues, JV; Pique, JM; Whittle, BJ | 1 |
| Kaneto, H; Senda, T; Takahashi, M | 1 |
| Biggs, DF; Goel, V | 1 |
| Bell, JA; Jaffe, JH | 1 |
| Jaffe, JH; Sharpe, LG | 2 |
| Go, VL; Yaksh, TL | 1 |
| Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P | 1 |
| Donnerer, J | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Barnes, PJ; Rogers, DF | 1 |
| Bourgoin, S; Gallissot, MC; Gozlan, H; Hamon, M; Menard, F; Vergé, D | 1 |
| Gamse, R; Saria, A | 1 |
| Kontani, H; Koshiura, R | 1 |
| Nagy, JI; van der Kooy, D | 1 |
| Barthó, L | 1 |
| Cassidy, SS; Coast, JR; Monsereenusorn, Y | 1 |
| Ishizuka, Y; Matsumiya, T; Oka, T; Sawa, A | 1 |
| Fibiger, HC; Nagy, JI; Reisine, TD; Staines, WA; Vincent, SR; Yamamura, HI | 1 |
| Barthó, L; Sebök, B; Szolcsányi, J | 1 |
| Louie, G; Tsou, K; Way, EL | 1 |
| Barthó, L; Holzer, P; Lembeck, F; Szolcsányi, J | 1 |
| Holzer, P | 1 |
| Matsumiya, T; Oka, T | 1 |
| Benedek, G; Obál, F; Szikszay, M | 1 |
| Benedek, G; Székely, JI; Szikszay, M | 1 |
| Ho, LT; Zochodne, DW | 1 |
| Dubner, R; Ruda, MA; Thomas, DA | 1 |
| Katsumata, K; Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Hosoki, R; Kurihara, T; Otsuka, M; Saito, K; Suzuki, H; Urayama, O; Yanagisawa, M; Yoshioka, K | 1 |
| Henry, JL; Pitcher, GM; Yashpal, K | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A | 2 |
| Katsumata, K; Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Andersson, RG; Lindström, EG | 1 |
| Griesbacher, T | 1 |
| Borghi, A; Ceserani, R; Dalla Rosa, C; Gallico, L; Tognella, S | 1 |
| Andreev, N; Dray, A; Urban, L | 1 |
| Igarashi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Tanihara, H | 1 |
| Jeftinija, S; Kojic, L; Urban, L | 1 |
| Saperas, E; Taché, Y | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Abbadie, C; Basbaum, AI; McKay, WR; Rohde, DS | 1 |
| Abbadie, C; Basbaum, AI; Chang, DS; McKay, WR; Rohde, DS | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Cruwys, S; Garrett, NE; Malcangio, M; Tomlinson, DR | 1 |
| Calixto, JB; Santos, AR | 1 |
| Heinemann, A; Holzer, P; Jocic, M; Pabst, MA; Schöninkle, E; Schuligoi, R | 1 |
| Fujibayashi, K; Kubota, K; Saito, K; Takahashi, T; Yanagisawa, M | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Amanzio, M; Arduino, C; Benedetti, F | 1 |
| Chiang, YC; Hu, JW; Sessle, JB; Sunakawa, M | 1 |
| Fischer, A; Undem, BJ | 1 |
| Levine, JD; Miao, FJ | 1 |
| Kuraishi, Y; Nagasawa, T; Satoh, M; Yamaguchi, T | 1 |
| Aikawa, N; Ohmori, K | 1 |
| Drummond, PD | 1 |
| Benbow, L; Corboz, MR; Egan, RW; Fawzi, AB; Hey, JA; Matasi, J; Rivelli, MA; Smith-Torhan, A; Tulshian, D; Zhang, H | 1 |
| Capasso, F; Capasso, R; Di Carlo, G; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Kadowaki, M; Nakano, H; Sugimori, S; Takaki, M; Yamanouchi, M; Yoneda, S | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Li, XQ; Sun, H; Zochodne, DW | 1 |
| Benowitz, NL; Levine, JD; Miao, FJ | 1 |
| Corboz, MR; Egan, RW; Fernandez, X; Hey, JA | 1 |
| Chidiac, JJ; Hawwa, NN; Jabbur, SJ; Jurjus, AR; Massaad, CA; Rifai, K; Saadé, NE | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos, F; de Souza, MM; Nunes, RJ; Yunes, RA | 1 |
| Kamei, J; Morita, K; Onodera, K | 1 |
| Ceccherelli, F; Gagliardi, G; Giron, G; Ruzzante, L | 1 |
| Flecknell, P; Laidlaw, A; Rees, JL | 1 |
| Arendt-Nielsen, L; Gibson, SJ; Graven-Nielsen, T; Laursen, RJ; Svensson, P | 1 |
| Anderson, WS; Bencherif, B; Campbell, JN; Frost, JJ; Sheth, RN | 1 |
| McDougall, JJ | 1 |
| Capasso, R; Mascolo, N | 1 |
| Ebrahimi, SA; Mahmoudian, M; Rostami, P; Zareie, MR | 1 |
| Ando, R; Kawamura, S; Watanabe, C; Yonezawa, A | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Arai, I; Hashimoto, Y; Kurachi, M; Takano, N | 1 |
| Chancellor, MB; de Groat, WC; Igawa, Y; Kamo, I; Nelson, JB; Nishizawa, O; Ogawa, T; Pflug, BR; Seki, S; Yoshimura, N | 1 |
| Maor, Y; Mechoulam, R; Pertwee, RG; Stevenson, LA; Thomas, A | 1 |
| Chancellor, MB; de Groat, WC; Kamo, I; Yoshimura, N | 1 |
| Cavalcante, IJ; Lima, MA; Maia, JL; Melo, CM; Rao, VS; Santos, FA; Silveira, ER; Vieira, GA | 1 |
| Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA | 1 |
| Chabot, JG; Jhamandas, K; Ma, W; Quirion, R; Trang, T | 1 |
| Ardenghi, JV; De Souza, MM; Filho, VC; Kanegusuku, M; Monache, FD; Niero, R; Yunes, RA | 1 |
| Achaval, M; Kalil-Gaspar, P; Marcuzzo, S; Molina, CG; Rigon, P | 1 |
| Cechinel-Filho, V; Gurgel, LA; Lima-Júnior, RC; Martins, DT; Rao, VS; Santos, FA | 1 |
| Hasegawa, M; Honda, K; Iwata, K; Kanda, K; Kitagawa, J; Kondo, M; Noma, N; Okamoto, R; Saito, K; Suzuki, I; Tsuboi, Y | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Leke, R; Pereira, MS; Schallenberger, C; Schmidt, AP; Souza, DO; Wofchuk, ST | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR | 1 |
| Fischer, MJ; Forster, AB; Messlinger, K; Reeh, PW | 1 |
| Chen, C; Pi, HF; Raun, HL; Wang, H; Wu, JZ; Zhang, JL; Zhang, P | 1 |
| Jang, CG; Kim, HC; Lee, SY; Nam, YS; Nguyen, TL | 1 |
| Arendt-Nielsen, L; Huang, L; Lei, J; Sui, MY; Tan, YX; Tjølsen, A; You, HJ | 1 |
| Du, JQ; Li, Q; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| Ji, W; Liang, J; Xiao, G | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Almeida, FR; Brandão, MS; Chaves, MH; Ferreira, EL; Lima, DF; Oliveira, JP; Pereira, SS | 1 |
| Du, JQ; Han, M; Li, Q; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Chen, HS; Li, FP; Li, XQ; Lin, Q; Liu, BJ; Qu, F; Wang, Y; Wen, WW | 1 |
| Cervantes-Durán, C; Espinosa de los Monteros-Zuñiga, A; Godínez-Chaparro, B; Izquierdo, T; Lozada, MC | 1 |
| Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA | 1 |
| Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV | 1 |
| Cai, Q; Hu, WP; Liu, TT; Liu, YM; Qiu, CY; Qiu, F; Qu, ZW | 1 |
| Du, JQ; Han, M; Liu, XH | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z | 1 |
| Coutinho, HD; de Albuquerque, TR; de Lacerda Neto, LJ; de Menezes, IR; de Oliveira, LR; de Souza, SD; Dos Santos, AT; Kerntopf, MR; Quintans-Júnior, LJ; Ramos, AG; Santos Sales, V; Wanderley, AG | 1 |
| Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K | 1 |
| Ishii, K; Ito, H; Kuroki, T; Mori, A; Nakahara, T; Sagawa, T; Sakamoto, K | 1 |
| Barbosa, TM; Barroso, LKV; Batista, FLA; Campos, AR; da Silva, ARA; Damasceno, MBMV; de Melo, JMA; de Oliveira, BA; Guedes, MIF; Holanda, DKR; Lima, MDCL; Magalhães, FEA; Moura, LFWG; Nogueira, AB; Santos, SAAR; Serpa, OF | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Haghani, J; Kooshki, R; Rahbar, I; Raoof, M | 1 |
| Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M | 1 |
| Hejnova, L; Marek, A; Markova, V; Melkes, B; Novotny, J | 1 |
| Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH | 1 |
| Abbasnejad, M; Dehghani, A; Esmaeili-Mahani, S; Lobbezoo, F; Raoof, M; Soleimani, AH | 1 |
1 trial(s) available for capsaicin and naloxone
| Article | Year |
|---|---|
Naloxone increases pain induced by topical capsaicin in healthy human volunteers.
Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Humans; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Psychophysics; Receptors, Opioid | 2002 |
142 other study(ies) available for capsaicin and naloxone
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
[Effects of capsaicin on spontaneous unit discharges in medial thalamic single neurons of cats (author's transl)].
Topics: Action Potentials; Animals; Bradykinin; Capsaicin; Cats; Fatty Acids, Unsaturated; Female; Male; Morphine; Naloxone; Neurons; Nociceptors; Tachyphylaxis; Thalamic Nuclei; Time Factors | 1977 |
Involvement of mu-opioid receptors in the antitussive effects of pentazocine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Benzomorphans; Capsaicin; Cough; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea.
Topics: Animals; Antigens; Biphenyl Compounds; Capsaicin; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Nerve Fibers; Neurokinin A; Peptide Fragments; Prostaglandin D2; Pyrilamine; Serotonin; Tetrodotoxin; Trachea; Vagus Nerve | 1992 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Modulation by opioids and by afferent sensory neurones of prostanoid protection of the rat gastric mucosa.
Topics: Animals; Capsaicin; Dinoprostone; Ethanol; Gastric Mucosa; Male; Morphine; Naloxone; Narcotics; Neurons, Afferent; Prostaglandins; Rats; Rats, Inbred Strains | 1992 |
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Irritants; Mice; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar; Uric Acid | 1992 |
An opioid peptide inhibits capsaicin-sensitive vasodilatation in the pig's skin.
Topics: Animals; Capsaicin; Electric Stimulation; Enkephalin, Methionine; Guanethidine; Microcirculation; Naloxone; Neurons; Skin; Swine; Tetrodotoxin; Vasodilation | 1992 |
Haemodynamic and abdominal motor reflexes elicited by neurotensin in anaesthetized guinea-pigs.
Topics: Animals; Atropine; Blood Pressure; Capsaicin; Cordotomy; Drug Interactions; Female; Guinea Pigs; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Morphine; Muscle Contraction; Naloxone; Neurotensin; Pentolinium Tartrate; Procaine; Reflex, Abdominal; Vagotomy | 1992 |
Interaction of myenteric neurons and extrinsic nerves in the intestinal inhibitory response induced by mesenteric nerve stimulation.
Topics: Animals; Atropine; Capsaicin; Electric Stimulation; Female; Ganglionic Blockers; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Mesentery; Muscle, Smooth; Myenteric Plexus; Naloxone; Neurons; Neuropeptides | 1991 |
Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by mu-opioids.
Topics: Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1991 |
Release of substance P-like immunoreactivity from the vascularly perfused rat stomach.
Topics: Animals; Bacitracin; Calcium; Capsaicin; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Gastric Mucosa; In Vitro Techniques; Naloxone; Perfusion; Potassium; Radioimmunoassay; Rats; Regional Blood Flow; Stomach; Substance P | 1990 |
Intrinsic reflexes mediated via peptidergic neurons in the smooth muscle esophagus of the hen.
Topics: Animals; Atropine; Capsaicin; Chickens; Electric Stimulation; Esophagus; Female; Hexamethonium; Hexamethonium Compounds; Muscle, Smooth; Myenteric Plexus; Naloxone; Neurons; Neuropeptides; Peristalsis; Reflex; Substance P | 1990 |
Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists.
Topics: Administration, Topical; Amino Acid Sequence; Animals; Blister; Capillary Permeability; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Inflammation; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Perfusion; Peripheral Nerves; Rats; Skin; Substance P; Vasodilation | 1990 |
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Cyclodextrins; Analgesia; Animals; beta-Cyclodextrins; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; Cyclodextrins; Dimethyl Sulfoxide; Electroencephalography; Enkephalin, Leucine-2-Alanine; gamma-Cyclodextrins; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Motor Activity; Naloxone; Narcotics; Pain; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Solubility; Substance P; Time Factors | 1991 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Endogenous opioids and ruthenium red inhibit the flare reaction in the pig skin by different mechanisms.
Topics: Animals; Capsaicin; Enkephalin, Methionine; Hypersensitivity, Immediate; Naloxone; Regional Blood Flow; Ruthenium Red; Skin; Skin Physiological Phenomena; Swine; Vasodilation | 1991 |
Spinal evoked potential P2 wave elicited by C fiber input and depressed by analgesic factors.
Topics: Analgesia; Animals; Capsaicin; Electroacupuncture; Evoked Potentials; Foot; Hot Temperature; Injections, Spinal; Male; Morphine; Naloxone; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1991 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Mechanism of intragastric nicotine protection against ethanol-induced gastric injury.
Topics: Animals; Capsaicin; Ethanol; Gastric Acid; Gastric Juice; Gastric Mucosa; Male; Naloxone; Nicotine; Rats; Rats, Inbred Strains; Regional Blood Flow | 1991 |
Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide.
Topics: Apamin; Calcitonin Gene-Related Peptide; Capsaicin; Colon; Humans; In Vitro Techniques; Intestinal Mucosa; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naloxone; Tachykinins; Tetrodotoxin; Vasoactive Intestinal Peptide | 1990 |
Mechanisms underlying the recovery of urinary bladder function following spinal cord injury.
Topics: Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Female; Male; Muscle, Smooth; Naloxone; Rats; Reflex; Spinal Cord Injuries; Urinary Bladder; Vasoactive Intestinal Peptide | 1990 |
Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF.
Topics: Animals; Blood Pressure; Capsaicin; Female; Gastric Mucosa; Male; Microcirculation; Morphine; Naloxone; Platelet Activating Factor; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow | 1990 |
Dual action mechanisms of KK-3, a newly synthesized leu-enkephalin derivative, in the production of spinal analgesic effects.
Topics: Analgesics; Animals; Benzomorphans; Capsaicin; Dipeptides; Injections, Spinal; Male; Mice; Naloxone; Reaction Time | 1990 |
Does capsaicin cause reflex bronchospasm in guinea-pigs?
Topics: Animals; Autonomic Agents; Bronchial Spasm; Capsaicin; Female; Guinea Pigs; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Male; Morphine; Naloxone; Neurons, Afferent; Pulmonary Circulation; Reflex; Respiration; Substance P | 1985 |
Electrophysiological evidence for a presynaptic mechanism of morphine withdrawal in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; In Vitro Techniques; Membrane Potentials; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Substance Withdrawal Syndrome; Synapses | 1986 |
Neonatal capsaicin modifies morphine withdrawal signs in the rat.
Topics: Animals; Animals, Newborn; Capsaicin; Female; Male; Morphine; Naloxone; Nasal Mucosa; Rats; Rats, Inbred Strains; Salivation; Substance P; Substance Withdrawal Syndrome; Tears | 1986 |
Release of substance P from the cat spinal cord.
Topics: 5,6-Dihydroxytryptamine; Analgesics; Animals; Blood Pressure; Capsaicin; Cats; Female; Intercellular Signaling Peptides and Proteins; Male; Naloxone; Neurotransmitter Agents; Peptides; Sciatic Nerve; Spinal Cord; Substance P; Sympathomimetics; Temperature; Time Factors | 1987 |
Neural pathways and pharmacological modulation of defecation reflex in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Defecation; Hexamethonium Compounds; Male; Naloxone; Neuropeptides; Phentolamine; Picrotoxin; Rats; Rats, Inbred Strains; Rectum; Reflex; Substance P | 1988 |
Primary sensory neurones and naloxone-precipitated morphine withdrawal.
Topics: Animals; Blood Pressure; Capsaicin; Female; Male; Morphine Dependence; Naloxone; Nerve Fibers; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex; Substance P; Substance Withdrawal Syndrome; Time Factors | 1989 |
Release of substance P by intrathecal KK-3, a newly synthesized Leu-enkephalin derivative.
Topics: Animals; Behavior, Animal; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Naloxone; Spinal Cord; Substance P | 1989 |
Captopril and capsaicin modify opioid withdrawal in the morphine-dependent rat.
Topics: Animals; Capsaicin; Captopril; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance P; Substance Withdrawal Syndrome | 1989 |
Opioid inhibition of neurally mediated mucus secretion in human bronchi.
Topics: Aged; Bronchi; Capsaicin; Female; Fucose; Hexoses; Humans; Male; Middle Aged; Morphine; Mucus; Naloxone; Proteins; Random Allocation; Sensory Receptor Cells | 1989 |
5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord.
Topics: Animals; Animals, Newborn; Antiemetics; Autoradiography; Benzamides; Benzomorphans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Male; Naloxone; Nerve Tissue Proteins; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord | 1989 |
Antidromic vasodilatation in the rat hindpaw measured by laser Doppler flowmetry: pharmacological modulation.
Topics: Adrenergic Fibers; Animals; Capsaicin; Cimetidine; Electric Stimulation; Enkephalin, Methionine; Female; Fentanyl; Hindlimb; Lasers; Male; Naloxone; Pyrilamine; Rats; Regional Blood Flow; Rheology; Skin; Vasodilation | 1987 |
The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.
Topics: Animals; Apomorphine; Capsaicin; Dextromethorphan; In Vitro Techniques; Levallorphan; Lung; Morphine; Morphine Derivatives; Naloxone; Neurons, Afferent; Pentazocine; Rana catesbeiana; Receptors, Opioid | 1985 |
Hyperalgesia mediated by peripheral opiate receptors in the rat.
Topics: Administration, Topical; Animals; Behavior, Animal; Capsaicin; Etorphine; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Naloxone-precipitated contractions of the guinea pig ileum made tolerant to a synthetic opioid peptide: evidence against the involvement of capsaicin-sensitive neurones.
Topics: Animals; Capsaicin; Enkephalin, Methionine; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone | 1988 |
Sensitivity of pulmonary chemo reflexes and lung inflation reflexes to repetitive stimulation and to inhibition with lidocaine and morphine.
Topics: Animals; Blood Gas Analysis; Capsaicin; Dogs; Female; Hemodynamics; Injections, Intra-Arterial; Lidocaine; Lung; Male; Morphine; Naloxone; Nerve Fibers; Pulmonary Artery; Reflex; Respiration | 1985 |
The effects of morphine, naloxone and capsaicin on C-fiber reflex and heat evoked discharge in acute spinal cats.
Topics: Animals; Capsaicin; Cats; Decerebrate State; Evoked Potentials; Female; Hot Temperature; Male; Morphine; Naloxone; Nerve Fibers; Reflex; Spinal Nerve Roots; Substance P | 1984 |
Neurotoxic action of capsaicin on spinal substance P neurons.
Topics: Animals; Behavior, Animal; Capsaicin; Choline O-Acetyltransferase; Fatty Acids, Unsaturated; Glutamate Decarboxylase; Kinetics; Male; Naloxone; Neuroglia; Neurons; Neurotoxins; Rats; Receptors, Opioid; Spinal Cord; Substance P; Synapses | 1980 |
Indirect evidence for the inhibition of enteric substance P neurones by opiate agonists but not by capsaicin.
Topics: Animals; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Female; Guinea Pigs; In Vitro Techniques; Intestines; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Neurons; Substance P; Synaptic Transmission | 1982 |
Manifestations of gut opiate withdrawal contracture and its blockade by capsaicin.
Topics: Animals; Capsaicin; Digestive System; Electric Stimulation; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Male; Muscle Contraction; Myenteric Plexus; Naloxone; Scopolamine; Serotonin; Serotonin Antagonists; Substance P; Substance Withdrawal Syndrome | 1982 |
Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P.
Topics: Animals; Atropine; Capsaicin; Endorphins; Fatty Acids, Unsaturated; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Substance P | 1982 |
Characterization of the stimulus-induced release of immunoreactive substance P from the myenteric plexus of the guinea-pig small intestine.
Topics: Animals; Calcium; Capsaicin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Female; Guinea Pigs; Male; Myenteric Plexus; Naloxone; Neurotransmitter Agents; Potassium; Substance P | 1984 |
The effect of naloxone on C-fiber reflex in cats.
Topics: Animals; Capsaicin; Cats; Female; Ketamine; Male; Naloxone; Reflex; Spinal Cord | 1984 |
Morphine tolerance and withdrawal in capsaicin--pretreated rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Capsaicin; Drug Tolerance; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1983 |
Thermoregulatory effects of D-met2-pro5-enkephalinamide.
Topics: Animals; Body Temperature Regulation; Capsaicin; Drug Antagonism; Drug Synergism; Enkephalin, Methionine; Humans; Male; Naloxone; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1983 |
Evidence that capsaicin hyperaemia of rat sciatic vasa nervorum is local, opiate-sensitive and involves mast cells.
Topics: Afferent Pathways; Amino Acid Sequence; Animals; Capsaicin; Male; Mast Cells; Molecular Sequence Data; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Substance P; Vasa Nervorum | 1993 |
Neonatal capsaicin treatment in rats results in scratching behavior with skin damage: potential model of non-painful dysesthesia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naloxone; Nerve Fibers; Rats; Rats, Sprague-Dawley; Self Mutilation; Skin; Substance P | 1994 |
Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1994 |
Involvement of enzymatic degradation in the inactivation of tachykinin neurotransmitters in neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Endopeptidases; In Vitro Techniques; Membranes; Motor Neurons; Naloxone; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Substance P; Synaptic Membranes | 1994 |
Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test.
Topics: Animals; Capsaicin; Endorphins; Hindlimb; Hot Temperature; Immersion; Male; Naloxone; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.
Topics: Animals; Antitussive Agents; Buprenorphine; Capsaicin; Cough; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid, mu; Time Factors | 1995 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Naloxone; Pain; Substance P | 1993 |
Morphine modulates contractile responses and neurokinin A-LI release elicited by electrical field stimulation or capsaicin in a guinea pig bronchial-tube preparation.
Topics: Animals; Bronchoconstriction; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone; Neurokinin A | 1995 |
Blood pressure reflexes following activation of capsaicin-sensitive afferent neurones in the biliopancreatic duct of rats.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Bile Ducts, Extrahepatic; Blood Pressure; Capsaicin; Electric Stimulation; Female; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Pancreatic Ducts; Phentolamine; Rats; Rats, Sprague-Dawley; Reflex; Sympathectomy, Chemical | 1994 |
Moguisteine: a novel peripheral non-narcotic antitussive drug.
Topics: Aerosols; Animals; Antitussive Agents; Binding, Competitive; Capsaicin; Citrates; Citric Acid; Codeine; Cough; Dogs; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Naloxone; Physical Stimulation; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Thiazoles; Thiazolidines | 1994 |
Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation.
Topics: Amino Acid Sequence; Animals; Capsaicin; Depression, Chemical; Electric Stimulation; Foot; Hyperalgesia; Male; Molecular Sequence Data; Naloxone; Narcotics; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Ultraviolet Rays | 1994 |
Antitussive effect of captopril, an angiotensin converting enzyme inhibitor, in the rat.
Topics: Animals; Antitussive Agents; Capsaicin; Captopril; Cough; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley | 1993 |
The selective activation of dorsal horn neurons by potassium stimulation of high threshold primary afferent neurons in vitro.
Topics: Action Potentials; Animals; Capsaicin; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Ganglia, Spinal; N-Methylaspartate; Naloxone; Neurons, Afferent; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1993 |
Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats.
Topics: Afferent Pathways; Animals; Capsaicin; Endotoxins; Escherichia coli; Gastric Acid; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Male; Naloxone; Premedication; Rats; Receptors, Interleukin-1; Receptors, Opioid; Recombinant Proteins; Sialoglycoproteins | 1994 |
Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse.
Topics: Analgesics; Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Reaction Time; Receptors, Opioid, mu | 1993 |
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity | 1996 |
Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat.
Topics: Animals; Animals, Newborn; Autonomic Nervous System; Capsaicin; Gastrointestinal Motility; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome; Weight Loss | 1997 |
The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of Fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine.
Topics: Animals; Behavior, Animal; Capsaicin; Decerebrate State; Immunohistochemistry; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Peripheral Nervous System; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord; Substance Withdrawal Syndrome | 1997 |
Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium.
Topics: Animals; Atrial Function; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Naltrexone; Neuromuscular Junction; Neurons, Afferent; Nociceptin; Opioid Peptides; Sensory Receptor Cells | 1997 |
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P | 1997 |
Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intradermal; Injections, Intraventricular; Male; Mice; Naloxone; Pain; Ruthenium Red | 1997 |
Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents.
Topics: Afferent Pathways; Animals; Brain Stem; Capsaicin; Female; Gastric Acid; Gastric Mucosa; Genes, fos; Hydrochloric Acid; Instillation, Drug; Morphine; Naloxone; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Spinal Cord; Transcription, Genetic; Vagus Nerve | 1998 |
A novel method for detecting the analgesic effect of drugs by quantifying body movement after noxious stimulation in neonatal rat.
Topics: Analgesics; Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Morphine; Movement; Naloxone; Narcotic Antagonists; Nociceptors; Noise; Pain Measurement; Pregnancy; Rats; Rats, Wistar; Stimulation, Chemical | 1998 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Somatotopic activation of opioid systems by target-directed expectations of analgesia.
Topics: Analgesia; Analysis of Variance; Anesthetics, Local; Capsaicin; Double-Blind Method; Foot; Functional Laterality; Hand; Humans; Infusions, Intravenous; Injections, Subcutaneous; Naloxone; Pain; Pain Threshold; Placebo Effect | 1999 |
Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp.
Topics: Animals; Bradykinin; Capsaicin; Dental Pulp; Electromyography; Evans Blue; Inflammation; Jaw; Male; Masseter Muscle; Mustard Plant; Naloxone; Narcotic Antagonists; Neutrophils; Pain; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley | 1999 |
Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus.
Topics: Analgesics, Opioid; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Oligopeptides; Receptors, Opioid, mu; Tachykinins | 1999 |
Neural and endocrine mechanisms mediating noxious stimulus-induced inhibition of bradykinin plasma extravasation in the rat.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Electric Stimulation; Endocrine Glands; Hypophysectomy; Knee Joint; Male; Mifepristone; Naloxone; Narcotic Antagonists; Nervous System Physiological Phenomena; Neurons, Afferent; Pain; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sympathetic Nervous System; Synovial Fluid | 1999 |
Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Male; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pruritus; Reaction Time; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Animals, Newborn; Antidiarrheals; Atropine; Benzimidazoles; Blood Pressure; Capsaicin; Intestines; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Papaverine; Pentobarbital; Phentolamine; Rats; Rats, Sprague-Dawley; Reflex; Vasodilator Agents | 1999 |
The effect of peripheral opioid block and body cooling on sensitivity to heat in capsaicin-treated skin.
Topics: Adolescent; Adult; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Naloxone; Receptors, Opioid | 2000 |
Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung.
Topics: Animals; Benzimidazoles; Bronchoconstriction; Capsaicin; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Lung; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Receptors, Opioid; Sulfur Radioisotopes | 2000 |
Effect of vanilloid drugs on gastrointestinal transit in mice.
Topics: Alkaloids; Animals; Arachidonic Acids; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Transit; Hexamethonium; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
Nociceptin inhibits capsaicin-sensitive contraction to mesenteric nerve stimulation in the guinea-pig isolated ileum.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; Enteric Nervous System; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Sympathetic Fibers, Postganglionic | 2000 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
Evidence that nitric oxide- and opioid-containing interneurons innervate vessels in the dorsal horn of the spinal cord of rats.
Topics: Animals; Capsaicin; Electric Stimulation; Enkephalin, Methionine; Enzyme Inhibitors; Immunohistochemistry; Interneurons; Laser-Doppler Flowmetry; Male; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2001 |
Endogenous opioids suppress activation of nociceptors by sub-nanomolar nicotine.
Topics: Adrenal Medulla; Analysis of Variance; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Hexamethonium; Inflammation; Knee Joint; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nicotine; Nociceptors; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Sciatic Nerve; Time Factors | 2001 |
Inhibitory activity of nociceptin/orphanin FQ on capsaicin-induced bronchoconstriction in the guinea-pig.
Topics: Animals; Benzimidazoles; Bronchoconstriction; Bronchoconstrictor Agents; Capsaicin; Drug Therapy, Combination; Guinea Pigs; Injections, Intravenous; Male; Naloxone; Neuropeptides; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Plethysmography, Whole Body; Protease Inhibitors; Receptors, Opioid; Vasodilator Agents | 2001 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Disease Models, Animal; Drug Interactions; Female; Formaldehyde; Gingiva; Inflammation; Male; Meloxicam; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Toothache | 2002 |
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
Topics: Acetic Acid; Aminopyrine; Analgesics, Non-Narcotic; Animals; Capsaicin; Formaldehyde; Imides; Indicators and Reagents; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peritonitis; Reaction Time; Structure-Activity Relationship | 2002 |
Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Antitussive Agents; Capsaicin; Codeine; Cough; Dose-Response Relationship, Drug; Drug Antagonism; Glyburide; Guinea Pigs; Male; Naloxone; Pinacidil; Potassium Channels; Thiazoles; Thiazolidines | 2002 |
Acupuncture modulation of capsaicin-induced inflammation: effect of intraperitoneal and local administration of naloxone in rats. A blinded controlled study.
Topics: Animals; Capsaicin; Edema; Electroacupuncture; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Neurogenic Inflammation; Random Allocation; Rats; Rats, Sprague-Dawley; Single-Blind Method | 2002 |
Production of acute and chronic itch with histamine and contact sensitizers in the mouse and guinea pig.
Topics: Acute Disease; Animals; Capsaicin; Chronic Disease; Dinitrochlorobenzene; Disease Models, Animal; Female; Guinea Pigs; Haptens; Histamine; Iontophoresis; Male; Mice; Mice, Inbred BALB C; Naloxone; Pruritus | 2002 |
Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers.
Topics: Adult; Afferent Pathways; Analgesics, Opioid; Capsaicin; Female; Humans; Hyperalgesia; Hypesthesia; Male; Mechanoreceptors; Muscle, Skeletal; Myofascial Pain Syndromes; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain Measurement; Physical Stimulation | 2002 |
Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.
Topics: Adrenergic Fibers; Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stimulation; Guanethidine; Hindlimb; Male; Naloxone; Nociceptin; Opioid Peptides; Pain; Rats; Rats, Wistar; Regional Blood Flow; Sympathetic Nervous System; Synovial Membrane; Vasoconstriction | 2003 |
The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro.
Topics: Animals; Atropine; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Hexamethonium; Humans; In Vitro Techniques; Male; Molecular Structure; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Phenylephrine; Rats; Rats, Wistar; Receptors, Tachykinin; Vas Deferens; Vasoconstrictor Agents | 2003 |
Interaction of noscapine with the bradykinin mediation of the cough response.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antitussive Agents; Bradykinin; Capsaicin; Captopril; Cough; Dose-Response Relationship, Drug; Drug Interactions; Enalapril; Guinea Pigs; Male; Naloxone; Narcotic Antagonists; Noscapine; Quinolines; Receptor, Bradykinin B2 | 2003 |
An assessment of vascular pain using the flexor reflex in anesthetized rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electromyography; Hindlimb; Injections, Intra-Arterial; Injections, Spinal; Injections, Subcutaneous; Lidocaine; Male; Morphine; Muscle, Skeletal; Naloxone; Pain Measurement; Procaine; Rats; Rats, Sprague-Dawley; Reflex, Stretch; Time Factors; Toes; Vascular Diseases | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.
Topics: Alprostadil; Animals; Antipruritics; Behavior, Animal; Capsaicin; Chlorpheniramine; Cyproheptadine; Dermatitis, Atopic; Dexamethasone; Dibucaine; Male; Mice; Mice, Inbred Strains; Naloxone; Pinacidil; Pruritus; Tacrolimus; Theophylline; Time Factors | 2004 |
Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats.
Topics: Afferent Pathways; Animals; Atrasentan; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Injections, Spinal; Muscle Hypertonia; Naloxone; Nerve Fibers, Unmyelinated; Peripheral Nerves; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder; Urination; Urodynamics | 2004 |
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; In Vitro Techniques; Isometric Contraction; Male; Mice; Morpholines; Naloxone; Naphthalenes; Phenylephrine; Piperidines; Pyrazoles; Rimonabant; Ruthenium Red; TRPV Cation Channels; Vas Deferens; Yohimbine | 2005 |
Differential effects of activation of peripheral and spinal tachykinin neurokinin(3) receptors on the micturition reflex in rats.
Topics: Acetates; Afferent Pathways; Animals; Capsaicin; Female; Naloxone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spine; Urination | 2005 |
12-Acetoxyhawtriwaic acid lactone, a diterpene from Egletes viscosa, attenuates capsaicin-induced ear edema and hindpaw nociception in mice: possible mechanisms.
Topics: Analgesics; Animals; Asteraceae; Capsaicin; Diterpenes; Diterpenes, Clerodane; Ear; Edema; Flowers; Glyburide; Hindlimb; Lactones; Male; Mice; Naloxone; Nociceptors; Substance P; Theophylline; TRPV Cation Channels | 2006 |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine | 2006 |
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Drug Administration Schedule; Endocannabinoids; Ganglia, Spinal; Hot Temperature; Immunologic Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid-Related Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2006 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Opioid; Ruthenium Red; Signal Transduction; Snails; TRPV Cation Channels | 2007 |
Dragon's blood from Croton urucurana (Baill.) attenuates visceral nociception in mice.
Topics: Abdominal Pain; Acetylcysteine; Administration, Oral; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Capsaicin; Clonidine; Croton; Cyclophosphamide; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Pentobarbital; Plant Extracts; Sleep; Time Factors | 2007 |
Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat.
Topics: Aging; Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Face; Naloxone; Narcotic Antagonists; Neural Pathways; Pain; Phosphorylation; Rats; Rats, Inbred F344; Sensory System Agents; Trigeminal Caudal Nucleus | 2008 |
Antinociceptive effects of intracerebroventricular administration of guanine-based purines in mice: evidences for the mechanism of action.
Topics: Analgesics; Animals; Brain Chemistry; Capsaicin; Chromatography, High Pressure Liquid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Hot Temperature; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Postural Balance; Psychomotor Performance; Reaction Time | 2008 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels | 2009 |
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium | 2009 |
High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors.
Topics: Acrolein; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Dose-Response Relationship, Drug; Extremities; Ganglia, Spinal; Hot Temperature; Humans; Ion Channel Gating; Mice; Morphine; Naloxone; Neurons; Skin; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2009 |
Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor.
Topics: Animals; Antitussive Agents; Capsaicin; Cevanes; Cholic Acids; Cough; Disease Models, Animal; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 2009 |
Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; TRPV Cation Channels | 2010 |
Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception.
Topics: Animals; Capsaicin; Dihydroxytryptamines; Hot Temperature; Hyperalgesia; Male; Models, Animal; Muscle, Skeletal; Naloxone; Nerve Fibers, Unmyelinated; Nociceptors; Rats; Rats, Sprague-Dawley; Reflex; Saline Solution, Hypertonic; Sciatic Nerve; Time Factors | 2010 |
Rostroventral medulla-mediated biphasic modulation of the rat cardiosomatic motor reflex.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Local; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Functional Laterality; Lidocaine; Male; Medulla Oblongata; Naloxone; Narcotic Antagonists; Neural Pathways; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Spinal Cord Injuries; Yohimbine | 2011 |
Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Inhibitory Concentration 50; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pain Perception; Peptide Fragments; Receptors, Opioid; Spinal Cord; Structure-Activity Relationship | 2011 |
Capsaicin induces reflex scratching in inflamed skin.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Freund's Adjuvant; Inflammation; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Pain; Pruritus; Receptors, Opioid, mu; Reflex; Sensory System Agents; Skin; Time Factors; TRPV Cation Channels | 2011 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice.
Topics: Acetic Acid; Acute Pain; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Disease Models, Animal; Formaldehyde; Glutamic Acid; Glyburide; Lecythidaceae; Male; Mice; Naloxone; Narcotic Antagonists; Phytotherapy; Plant Extracts; Plant Leaves | 2013 |
Lateral reticular nucleus modulates the cardiosomatic reflex evoked by intrapericardial capsaicin in the rat.
Topics: Animals; Capsaicin; Electric Stimulation; Electromyography; Glutamic Acid; Heart; Male; Medulla Oblongata; Muscle Contraction; Muscle, Skeletal; Naloxone; Neural Pathways; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents | 2013 |
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; Male; Naloxone; Nociception; Oxidopamine; Pain; Rats; Rats, Sprague-Dawley; Restraint, Physical; Sciatic Nerve; Stress, Psychological; Sympathetic Nervous System | 2013 |
Mechanisms underlying the antinociceptive effect of mangiferin in the formalin test.
Topics: Analgesics; Animals; Capsaicin; Formaldehyde; Glyburide; Male; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Nociception; Quinoxalines; Rats; Rats, Wistar; Serotonin; Xanthones | 2013 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; Formaldehyde; Glutamic Acid; Histamine; Inflammation; Male; Mice; Naloxone; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats, Wistar; Sterculia | 2014 |
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociception; Pain; Protons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; TRPV Cation Channels | 2014 |
[The effect of electrical stimulation of nucleus tractus solitarius on cardiac nociception and its spinal cord mechanism in rat].
Topics: Animals; Capsaicin; Electric Stimulation; Heart; Injections, Spinal; Naloxone; Nociception; Rats; Rats, Sprague-Dawley; Reflex; Solitary Nucleus; Spinal Cord; Yohimbine | 2015 |
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25 | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Ericales; Ethanol; Female; Flavonoids; Gastrointestinal Motility; Glyburide; Histamine; Indomethacin; Male; Mice; Mucus; Naloxone; NG-Nitroarginine Methyl Ester; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Stomach Ulcer; Water; Yohimbine | 2017 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; Mice; Naloxone; Narcotic Antagonists; Nociception; Pain; Receptors, Opioid; Recognition, Psychology; Social Behavior; Stress, Psychological; Visual Perception | 2017 |
Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina.
Topics: Animals; beta-Endorphin; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Male; Naloxone; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Retina; Signal Transduction; Substance P; TRPV Cation Channels | 2017 |
Orofacial antinociceptive effect of Mimosa tenuiflora (Willd.) Poiret.
Topics: Acrolein; Analgesics; Animals; Antioxidants; Capsaicin; Chemical Fractionation; Chlorocebus aethiops; Ethanol; Facial Pain; Glutamic Acid; Glyburide; Mice; Mimosa; Motor Activity; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Phenols; Plant Extracts; Rats, Wistar; Temporomandibular Joint; Vero Cells | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
The effect of central administration of alpha-pinene on capsaicin-induced dental pulp nociception.
Topics: Animals; Bicuculline; Bicyclic Monoterpenes; Capsaicin; Cerebral Ventricles; Dental Pulp; Fluorescent Antibody Technique; Male; Monoterpenes; Naloxone; Nociception; Random Allocation; Rats; Rats, Wistar | 2019 |
Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Benzalkonium Compounds; Capsaicin; Cornea; Corneal Injuries; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Propionates; Sensory System Agents; Trigeminal Ganglion | 2019 |
Naloxone Is a Potential Binding Ligand and Activator of the Capsaicin Receptor TRPV1.
Topics: Calcium; Capsaicin; Cell Membrane; HEK293 Cells; Humans; Ligands; Naloxone; Narcotic Antagonists; TRPV Cation Channels | 2020 |
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Male; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Receptors, N-Methyl-D-Aspartate; Ruthenium Red; Triterpenes; TRPV Cation Channels; Zebrafish; Zebrafish Proteins | 2020 |
Apelin signalling in the periaqueductal grey matter alleviates capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rat.
Topics: Animals; Apelin; Capsaicin; Facial Pain; Male; Memory Disorders; Naloxone; Periaqueductal Gray; Rats; Rats, Wistar; Spatial Learning | 2023 |