capsaicin and n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide

Topics: Acid Sensing Ion Channel Blockers; Acidosis; Adult; Amiloride; Analgesics; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Oximes; Pain; Pain Measurement; Pyrazines; Pyridines; TRPA1 Cation Channel; TRPV Cation Channels

Topics: Africa; Alkaloids; Calcium; Capsaicin; Humans; Ibogaine; Menthol; Molecular Structure; Plant Bark; Pyrimidinones; Transient Receptor Potential Channels; Trees; TRPV Cation Channels; Voacanga

Topics: Animals; Benzoxazines; Binding Sites; Humans; Protein Binding; Rats; Structure-Activity Relationship; Substrate Specificity; TRPV Cation Channels; Urea

Topics: Analgesics; Animals; Antineoplastic Agents; Capsaicin; Cell Line, Tumor; Doxorubicin; Drug Design; Gastric Mucosa; HEK293 Cells; Humans; Hydrogen Sulfide; Male; Mice; Rats; Structure-Activity Relationship; TRPV Cation Channels

Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Capsaicin; Cells, Cultured; Drug Discovery; Female; Humans; Inflammation; Keratinocytes; Laurates; Mice; Mice, Inbred C57BL; Skin Diseases; TRPV Cation Channels

Topics: Animals; Drug Discovery; Humans; Molecular Structure; Pyridones; Structure-Activity Relationship; TRPV Cation Channels; Urea

Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug

Topics: Amino Acid Sequence; Animals; Biological Transport; Calcium; Capsaicin; Cell Line; Cloning, Molecular; Diterpenes; DNA, Complementary; Dogs; Dopamine; Dose-Response Relationship, Drug; Fluorometry; Genetic Vectors; Genotype; Humans; Molecular Sequence Data; Mutation, Missense; Phorbol Esters; Phylogeny; Pyrazines; Pyridines; Receptors, Drug; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transfection

Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation

Topics: Animals; Binding Sites; Capsaicin; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Protein Binding; Protein Conformation; Protons; Pyrazines; Pyridines; Rabbits; Rats; TRPV Cation Channels

Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels

Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels

Topics: Amino Acid Sequence; Animals; Bronchi; Capsaicin; Cell Line; Cold Temperature; Cytokines; Endoplasmic Reticulum; Epithelial Cells; Humans; Lung; Menthol; Molecular Sequence Data; Pyrazines; Pyridines; Thapsigargin; Thermoreceptors; Thermosensing; TRPM Cation Channels

Topics: Acids; Ammonium Chloride; Animals; Calcium; Capsaicin; Cell Line, Transformed; Ganglia, Spinal; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pyrazines; Pyridines; Sensory Receptor Cells; Sensory System Agents; Transfection; TRPV Cation Channels

Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Gastric Emptying; Gastrointestinal Transit; Hexamethonium; Ileus; Lipopolysaccharides; Male; Mice; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Receptors, Calcitonin Gene-Related Peptide; Sepsis; TRPV Cation Channels

Topics: Animals; Atropine; Capsaicin; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Pyrazines; Pyridines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rectum; Substance P; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase

Topics: Acrosome Reaction; Calcium; Capsaicin; Chemotaxis; Fluorescent Antibody Technique, Indirect; Humans; Male; Models, Biological; Progesterone; Pyrazines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sperm Motility; Spermatozoa; TRPM Cation Channels

Topics: Animals; Capsaicin; Clotrimazole; Cold Temperature; Humans; Imidazoles; Ion Channel Gating; Menthol; Mice; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Phenotype; Pyrazines; Pyridines; Structure-Activity Relationship; TRPM Cation Channels; Tyrosine

Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels

Topics: Analysis of Variance; Angiotensin II; Anilides; Animals; Capsaicin; Chelating Agents; Cinnamates; Diuretics, Osmotic; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Piperidines; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Supraoptic Nucleus; TRPV Cation Channels; Vasoconstrictor Agents

Topics: Acrosome Reaction; Animals; Capsaicin; Humans; Ion Channel Gating; Male; Menthol; Mice; Mice, Knockout; Pyrazines; Pyridines; Pyrimidinones; Spermatozoa; Temperature; Testis; TRPM Cation Channels

Topics: Animals; Capsaicin; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Kidney Pelvis; Male; Mice; Muscle Contraction; Muscle, Smooth; Organ Specificity; Pyrazines; Pyridines; Rats; Trachea; TRPV Cation Channels; Urinary Bladder

Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Protein Kinase C; Pyrazines; Pyridines; Rats; Rats, Inbred Strains; Spinal Cord; TRPV Cation Channels

Topics: Acetanilides; Anesthetics, Inhalation; Animals; Capsaicin; Desflurane; Guinea Pigs; Isoflurane; Isothiocyanates; Laryngeal Nerves; Larynx; Male; Methyl Ethers; Nerve Fibers; Neurons; Purines; Pyrazines; Pyridines; Sevoflurane; Solitary Nucleus; Time Factors; Transient Receptor Potential Channels

Topics: Animals; Antigens; Antipruritics; beta 2-Microglobulin; Capsaicin; CD4-Positive T-Lymphocytes; Cell Proliferation; Colitis; Cytokines; Disease Models, Animal; Ligands; Lymphoid Tissue; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Pyrazines; Pyridines; Signal Transduction; TRPV Cation Channels

Topics: Adult; Animals; Arsenicals; Calcium; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Humans; Membrane Potentials; Neurons; Oxidation-Reduction; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels

Topics: Action Potentials; Animals; Calcium Signaling; Capsaicin; Cells, Cultured; HEK293 Cells; Humans; Male; Mannitol; Neurons; Osmolar Concentration; Oxytocin; Pyrazines; Pyridines; Rats; Rats, Transgenic; Rats, Wistar; Supraoptic Nucleus; Temperature; TRPV Cation Channels

Topics: Acetanilides; Alkaloids; Animals; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Piperidines; Polyunsaturated Alkamides; Purines; Pyrazines; Pyridines; Trachea; TRPV Cation Channels; Urinary Bladder

Topics: Acetanilides; Animals; Capsaicin; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neurons; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Sodium Channel Blockers; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; Thymol; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels

Topics: Animals; Blotting, Western; Calcium; Calcium Signaling; Capsaicin; Cold Temperature; Cytosol; In Vitro Techniques; Ion Channel Gating; Male; Menthol; Mesenteric Arteries; Monoterpenes; Pyrazines; Pyridines; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Ruthenium Red; TRPM Cation Channels; TRPV Cation Channels; Vasodilation

Topics: Calcium; Capsaicin; Cell Line; Epithelial Cells; Humans; Interleukin-6; Membrane Potentials; Patch-Clamp Techniques; Pyrazines; Pyridines; Pyrimidinones; Thyronines; TRPM Cation Channels; TRPV Cation Channels

Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels

Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels