capsaicin has been researched along with morphine in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (22.00) | 18.7374 |
| 1990's | 55 (27.50) | 18.2507 |
| 2000's | 60 (30.00) | 29.6817 |
| 2010's | 37 (18.50) | 24.3611 |
| 2020's | 4 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bevan, S; Campbell, EA; Dray, A; Hughes, GA; James, I; Masdin, KJ; Walpole, CS; Winter, J; Wrigglesworth, R | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ando, R; Kisara, K; Onodera, K; Shima, K | 1 |
| Kamei, J; Kasuya, Y; Katsuma, K | 1 |
| Barnes, PJ; Kuo, HP; Rogers, DF; Rohde, JA | 1 |
| Arts, KS; Fujimoto, JM; Tseng, LF | 1 |
| Hosoki, R; Otsuka, M; Yanagisawa, M | 1 |
| Esplugues, JV; Moncada, S; Whittle, BJ | 2 |
| Campbell, EA; Perkins, MN | 1 |
| Lemieux, M; Rioux, F | 1 |
| Kamei, J; Kasuya, Y | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Braun, KP; Goodman, M; Jang, JD; Nishiuchi, Y; Ro, SG; Yaksh, TL | 1 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Boura, AL; King, RG; Rechtman, MP | 1 |
| McEvoy, RD; Reynolds, AM; Scicchitano, R; Zadow, SP | 1 |
| Dickenson, A; Dray, A | 1 |
| Gebhart, GF; Ness, TJ; Randich, A | 1 |
| Lopez-Belmonte, J; Whittle, BJ | 1 |
| Li, R; Yu, YX | 1 |
| Nance, D; Reid, A; Sawynok, J | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 1 |
| Barthó, L; Herz, A; Stein, C | 1 |
| Ekman, P; Liedberg, H; Lundeberg, T; Nordling, L | 1 |
| Esplugues, JV; Whittle, BJ | 1 |
| Esplugues, JV; Pique, JM; Whittle, BJ | 1 |
| Biggs, DF; Goel, V | 2 |
| Fasmer, OB; Hole, K; Hunskaar, S | 1 |
| Bell, JA; Jaffe, JH | 1 |
| Jaffe, JH; Sharpe, LG | 2 |
| Chahl, LA; Lynch, AM | 1 |
| Bossut, D; Frenk, H; Mayer, DJ; Urca, G | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Hamon, M; Mauborgne, A; Pohl, M | 1 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Sawynok, J; Sweeney, MI; White, TD | 2 |
| Barnes, PJ; Rogers, DF | 1 |
| Buchheit, KH; Engel, G; Mutschler, E; Richardson, B | 1 |
| Bechara, A; van der Kooy, D; Zito, KA | 1 |
| Gudelsky, GA; Koenig, JI; Meltzer, HY | 1 |
| Brini, A; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Nakayama, T | 1 |
| Kontani, H; Koshiura, R | 1 |
| Nagy, JI; van der Kooy, D | 1 |
| Choudry, NB; Fuller, RW; Karlsson, JA; Pride, NB | 1 |
| Chahl, LA | 1 |
| Andoh, R; Kisara, K; Miyagawa, T; Osawa, K; Sakurada, S; Sakurada, T | 1 |
| Basbaum, AI; Dardick, SJ; Helms, C; Levine, JD; Roizen, MF | 1 |
| Nakahama, H; Niizuma, H; Otsuki, T; Suzuki, J | 1 |
| Cassidy, SS; Coast, JR; Monsereenusorn, Y | 1 |
| Ishizuka, Y; Matsumiya, T; Oka, T; Sawa, A | 1 |
| Gamse, R; Jessell, TM; Leeman, SE; Mudge, AW; Yaksh, TL | 1 |
| Buck, SH; Burks, TF; Deshmukh, PP; Miller, MS; Yamamura, HI | 1 |
| Barthó, L; Sebök, B; Szolcsányi, J | 1 |
| Bodnar, RJ; Kirchgessner, A; Mulhern, J; Nilaver, G; Zimmerman, EA | 1 |
| Brown, MR; Buck, SH; Burks, TF; Davis, TP; Walsh, JH; Yamamura, HI | 1 |
| Gale, TF; Kirby, ML; Mattio, TG | 1 |
| Butler, JM; Cole, DF; Zhang, SQ | 1 |
| Benedek, G; Obál, F; Szikszay, M | 2 |
| Abbott, FV; Grimes, RW; Melzack, R | 1 |
| Farmer, RW; LaHann, TR | 1 |
| Andoh, R; Kisara, K; Ohsawa, K; Sakurada, S; Takahashi, M | 1 |
| Lembeck, F; Skofitsch, G | 1 |
| Andoh, R; Kisara, K; Miyagawa, T; Ohsawa, K; Sakurada, S; Shima, K; Takahashi, M | 1 |
| Chahl, LA; Morton, CR | 1 |
| Jancsó, G; Jancsó-Gábor, A | 1 |
| Ho, LT; Zochodne, DW | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Mattiasson, A | 1 |
| Dubner, R; Ruda, MA; Thomas, DA | 1 |
| Katsumata, K; Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Blanchard, JC; Carruette, A; Garret, C; Laduron, PM; Montier, F; Moussaoui, SM | 1 |
| Andersson, RG; Lindström, EG | 1 |
| Griesbacher, T | 1 |
| Igarashi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Tanihara, H | 1 |
| Birder, LA; de Groat, WC | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Ault, B; Hildebrand, LM | 1 |
| Boyer, V; Harf, A; Jarreau, PH; Levame, M; Lorino, H; Macquin-Mavier, I | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Kisara, K; Manome, Y; Sakurada, C; Sakurada, S; Sakurada, T; Tan-no, K; Wako, K | 1 |
| Abbadie, C; Basbaum, AI; McKay, WR; Rohde, DS | 1 |
| Hansson, P; Kinnman, E; Nygårds, EB | 1 |
| Bieger, D; Loomis, CW; Yao, D | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Diop, L; Friese, N; Rivière, PJ | 1 |
| Pirec, V; Proudfit, HK; Yeomans, DC | 1 |
| Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M | 1 |
| De Freitas, GA; Santos, AR; Vedana, EM | 1 |
| Heinemann, A; Holzer, P; Jocic, M; Pabst, MA; Schöninkle, E; Schuligoi, R | 1 |
| Fujibayashi, K; Kubota, K; Saito, K; Takahashi, T; Yanagisawa, M | 1 |
| Calixto, JB; Miguel, OG; Santos, AR; Yunes, RA | 1 |
| Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D | 1 |
| Lembeck, F; Sieler, D | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suarez-Roca, H | 1 |
| Ito, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Watanabe, M | 1 |
| Andrews, PL; Hagiwara, H; Kakaimoto, S; Matsuki, N; Okada, F; Toyoda, M; Woods, AJ | 1 |
| Carstens, E; Jinks, SL | 1 |
| Hazato, T; Inoue, M; Matsunaga, S; Ueda, H; Yamamoto, Y | 1 |
| Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC | 1 |
| Ito, H; Kiso, T; Matsumoto, N; Nagakura, Y; Okada, M; Tamura, S; Toya, T; Yamaguchi, T | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JMA; Martinez-Caro, L | 1 |
| Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH | 1 |
| Borgland, SL; Christie, MJ; Connor, M | 1 |
| Chidiac, JJ; Hawwa, NN; Jabbur, SJ; Jurjus, AR; Massaad, CA; Rifai, K; Saadé, NE | 1 |
| Dallel, R; Pajot, J; Pelissier, T | 1 |
| Barletta, J; Gear, RW; Green, P; Levine, JD; Luo, L; Schmidt, BL; Tambeli, CH | 1 |
| Calixto, JB; Ferreira, J; Santos, AR; Trentin, AP; Yunes, RA | 1 |
| Atweh, SF; Bach, JF; Dardenne, M; Jabbur, SJ; Saadé, NE; Safieth-Garabedian, B | 1 |
| Kline, RH; Vierck, CJ; Wiley, RG | 1 |
| Jänig, W; Jasmin, L; Levine, JD; Miao, FJ | 1 |
| Ueda, H | 1 |
| Epstein, OI; Kovaleva, VL; Zak, MS | 1 |
| Barrett, AC; Picker, MJ; Smith, ES | 1 |
| Alvarez, P; Hernández, A; Paeile, C; Pelissier, T; Saavedra, G | 1 |
| Ando, R; Kawamura, S; Watanabe, C; Yonezawa, A | 1 |
| Anand, KJ; Garg, S; Liu, JG; Rovnaghi, CR | 1 |
| Baamonde, A; Fresno, MF; Hidalgo, A; Lastra, A; Llames, S; Meana, A; Menéndez, L | 1 |
| Jones, CK; Peters, SC; Shannon, HE | 1 |
| Klyukinov, M; Manering, N; Nemenov, MI; Shafer, SL; Tzabazis, A; Yeomans, DC | 1 |
| Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S | 1 |
| Ji, RR; Kawasaki, Y; Kohno, T | 1 |
| Laurito, CE; Lu, Y; Pappas, GD; Peters, MC; Vota-Vellis, G; Wilson, SP; Yeomans, DC | 1 |
| Fujita, T; Jin, YH; Nishioka, H; Wakabayashi, K; Yonehara, N | 1 |
| Beyer, CE; Brandt, MR; Smith, VA | 1 |
| Kuramasu, A; Mobarakeh, JI; Sakurada, S; Takahashi, K; Yanai, K | 1 |
| Cabot, PJ; Hermanussen, S; Kapitzke, D; Monteith, GR; Vetter, I | 1 |
| Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Vetter, I; Wyse, BD | 2 |
| Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA | 1 |
| Chabot, JG; Jhamandas, K; Ma, W; Quirion, R; Trang, T | 1 |
| Frymoyer, AR; Petersen, KL; Rowbotham, MC | 1 |
| Childeric, A; Dallel, R; Gaydier, AM; Luccarini, P; Voisin, D | 1 |
| Ardenghi, JV; De Souza, MM; Filho, VC; Kanegusuku, M; Monache, FD; Niero, R; Yunes, RA | 1 |
| Achaval, M; Kalil-Gaspar, P; Marcuzzo, S; Molina, CG; Rigon, P | 1 |
| Cechinel-Filho, V; Gurgel, LA; Lima-Júnior, RC; Martins, DT; Rao, VS; Santos, FA | 1 |
| Chen, YF; Li, N; Qin, LP; Rahman, K; Wu, JZ; Zhang, H; Zhang, QY; Zheng, HC | 1 |
| Lomas, LM; Picker, MJ; Terner, JM | 1 |
| Cechinel Filho, V; de Souza, MM; Delle Monache, F; Delle Monache, G; Fischer, LG; Malheiros, A; Santos, D; Serafin, C | 1 |
| Palmery, M; Piccolotti, P; Pimpinella, G; Romanelli, L; Tucci, P; Valeri, P | 1 |
| Hironaka, K; Ogino, A; Ozaki, N; Shinoda, M; Sugiura, Y; Urano, H; Yasui, M | 1 |
| Brennan, TJ; Gavva, NR; Wu, C | 1 |
| Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I | 1 |
| De Felice, M; Fioravanti, B; Gardell, LR; Ibrahim, M; King, T; Lai, J; Luo, MC; Malan, TP; Medler, KA; Ossipov, MH; Porreca, F; Stucky, CL; Vanderah, TW; Yamamura, HI | 1 |
| Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H | 1 |
| Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL | 1 |
| Al-Asmar, B; Chidiac, JJ; Jabbur, SJ; Rifai, K; Saadé, NE | 1 |
| Akiyama, T; Carstens, E; Carstens, MI; Merrill, AW; Zanotto, K | 1 |
| Fischer, MJ; Forster, AB; Messlinger, K; Reeh, PW | 1 |
| Aguiar, DC; Guimarães, FS; Moreira, FA; Terzian, AL | 1 |
| Chen, YF; Huang, Y; Qin, LP; Tang, WZ; Zheng, HC | 1 |
| Hasan, W; McCarson, KE; Rook, JM | 1 |
| Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV; Yamamura, HI | 1 |
| Iwata, Y; Komatsu, T; Kuwahata, H; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M | 1 |
| Calò, G; Guerrini, R; Hu, E; Ko, MC | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Bock, E; Holzer, P; Mitrovic, M; Pabst, MA; Shahbazian, A | 1 |
| Almeida, JR; Araujo, AA; Araújo, DA; Bonjardim, LR; De Sousa, DP; Gelain, DP; Gonçalves, JC; Melo, MS; Onofre, AC; Quintans-Júnior, LJ | 1 |
| Jang, CG; Kim, HC; Lee, SY; Nam, YS; Nguyen, TL | 1 |
| Bai, ZT; Cheng, M; Hua, LM; Ji, YH; Jiang, F; Liu, T; Pang, XY; Shi, J; Shu, XQ; Zhang, JW; Zhou, JJ | 1 |
| Akiyama, T; Carstens, E; Carstens, MI | 1 |
| Largent-Milnes, TM; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV | 1 |
| Chen, YF; Hou, GX; Huang, Y; Shi, GB; Wang, X; Yan, M; Zhao, MH; Zhao, QC | 1 |
| Ji, W; Liang, J; Xiao, G | 1 |
| Daugherty, D; Dykstra, LA; Henry, FE; Miller, LL; Picker, MJ | 1 |
| Carlson, N; Hartrick, CT; Hartrick, S; Pestano, C | 1 |
| Akbarali, HI; Dewey, WL; Gade, AR; Ross, GR | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Dolan, S; Graham, A; Iannitti, T | 1 |
| Hoeben, E; Mangold, B; Reitmeir, P; Rusch, S; Schaffler, K; Smit, JW; Upmalis, D | 1 |
| Araujo, BS; Botelho, MA; Damascena, NP; Dias, AS; Estevam, CS; Lima, AC; Melo, MS; Oliveira, MG; Paixão, MS; Quintans, LJ; Santana, MT | 1 |
| Fakhoury, AA; Flood, PD; Mirza, FG; Rowley, TJ | 1 |
| Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C | 1 |
| Khasabov, SG; Simone, DA | 1 |
| Alves, PB; Araújo, AA; Bonjardim, LR; de Lucca Júnior, W; Lucchese, AM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Siqueira-Lima, PS | 1 |
| Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA | 1 |
| Adam, G; Benedek, G; Horvath, G; Kekesi, G; Morvay, Z; Nagy, E; Petrovszki, Z; Tuboly, G | 1 |
| Cai, Q; Hu, WP; Liu, TT; Liu, YM; Qiu, CY; Qiu, F; Qu, ZW | 1 |
| Currò, D; Greco, MC; Lisi, L; Navarra, P; Tringali, G | 1 |
| Gao, GD; Guo, H; Heng, LJ; Huang, B; Ma, LT; Song, J; Wang, P; Xu, GZ; Yuan, WX | 1 |
| Allen, KD; Caudle, RM; Jacobs, BY; Kloefkorn, HE; Lakes, EH; Neubert, JK; Rohrs, EL | 1 |
| Bertelsen, MF; James, LE; Wang, T; Williams, CJ | 1 |
| Itomi, Y; Kawamura, T; Tsukimi, Y | 1 |
| Almeida, JRGS; Araújo, AAS; Castro, FF; Coutinho, HDM; Gopalsamy, RG; Martins, AOBPB; Menezes, IRA; Oliveira, MRC; Oliveira, RCM; Quintans, JSS; Quintans-Júnior, LJ; Serafini, MR; Shanmugam, S; Silva, BAF; Silva, JC; Thangaraj, P | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
| Braga, RM; de Almeida, RN; de Castro, RD; de Sousa, DP; de Sousa, FB; deM Pordeus, LC; Tomaz-Morais, JF | 1 |
| Artacho-Cordón, A; Cendán, CM; Entrena, JM; González-Cano, R; Nieto, FR; Tejada, MÁ; Wood, JN | 1 |
| Alkhatib, O; Andersson, DA; Bevan, S; Gentry, C; Quallo, T | 1 |
| De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Chen, Q; Chen, X; Feng, Y; Fu, F; Jiao, C; Qian, X; Sun, L; Wang, L; Wu, H; Xu, F; Xu, L; Xu, Q; Yao, H; Zhang, W | 1 |
| Chung, JM; Hankerd, K; La, JH; McDonough, KE; Tang, SJ; Wang, J | 1 |
| Arai, I; Saito, S; Takahashi, K; Takeda, H; Tsuji, M | 1 |
1 review(s) available for capsaicin and morphine
| Article | Year |
|---|---|
Thermosensitive neurons in the brain.
Topics: Animals; Anterior Hypothalamic Nucleus; Biogenic Amines; Body Temperature Regulation; Brain; Capsaicin; Dronabinol; Female; Medulla Oblongata; Morphine; Nerve Tissue Proteins; Neurons; Osmolar Concentration; Preoptic Area; Progesterone; Pyrogens; Species Specificity; Temperature | 1985 |
6 trial(s) available for capsaicin and morphine
| Article | Year |
|---|---|
Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Capsaicin; Codeine; Cough; Drug Interactions; Female; Humans; Male; Morphine; Narcotics | 1988 |
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Capsaicin; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Morphine; Pain; Thigh | 2007 |
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Drug Administration Routes; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Hypnotics and Sedatives; Injections, Intradermal; Injections, Intravenous; Male; Middle Aged; Morphine; Pain; Pain Measurement; Placebos; Pregabalin; Treatment Outcome; Young Adult | 2008 |
Capsaicin instillation for postoperative pain following total knee arthroplasty: a preliminary report of a randomized, double-blind, parallel-group, placebo-controlled, multicentre trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Capsaicin; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Oxycodone; Pain Measurement; Pain, Postoperative; Placebos; Range of Motion, Articular; Sensory System Agents; Young Adult | 2011 |
Tachycardia in response to remote capsaicin injection as a model for nociception in the ball python (Python regius).
Topics: Analgesics, Opioid; Animals; Boidae; Butorphanol; Capsaicin; Disease Models, Animal; Heart Rate; Morphine; Nociception; Prospective Studies; Sensory System Agents; Tachycardia | 2016 |
Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Male; Mice; Monoterpenes; Morphine; Pain Measurement | 2017 |
193 other study(ies) available for capsaicin and morphine
| Article | Year |
|---|---|
Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.
Topics: Administration, Oral; Analgesics; Animals; Capsaicin; Female; Guinea Pigs; Magnetic Resonance Spectroscopy; Mice; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship | 1996 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[Effects of capsaicin on spontaneous unit discharges in medial thalamic single neurons of cats (author's transl)].
Topics: Action Potentials; Animals; Bradykinin; Capsaicin; Cats; Fatty Acids, Unsaturated; Female; Male; Morphine; Naloxone; Neurons; Nociceptors; Tachyphylaxis; Thalamic Nuclei; Time Factors | 1977 |
Involvement of mu-opioid receptors in the antitussive effects of pentazocine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Benzomorphans; Capsaicin; Cough; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
Differential inhibitory effects of opioids on cigarette smoke, capsaicin and electrically-induced goblet cell secretion in guinea-pig trachea.
Topics: Animals; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Methacholine Compounds; Morphine; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Smoking; Substance P; Trachea; Vagus Nerve | 1992 |
Involvement of dynorphin A and not substance P in the spinal antianalgesic action of capsaicin against morphine-induced antinociception in mice.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Spine; Substance P | 1992 |
The isolated spinal cord-skin preparation of the newborn rat and effects of some algogenic and analgesic substances.
Topics: Action Potentials; Analgesics; Animals; Animals, Newborn; Bicuculline; Calcitonin Gene-Related Peptide; Capsaicin; Cerebrospinal Fluid; Enkephalin, Methionine; Morphine; Potassium Chloride; Prostaglandins E; Rats; Skin; Somatostatin; Spinal Cord; Substance P | 1992 |
Modulation by opioids and by afferent sensory neurones of prostanoid protection of the rat gastric mucosa.
Topics: Animals; Capsaicin; Dinoprostone; Ethanol; Gastric Mucosa; Male; Morphine; Naloxone; Narcotics; Neurons, Afferent; Prostaglandins; Rats; Rats, Inbred Strains | 1992 |
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Irritants; Mice; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar; Uric Acid | 1992 |
Haemodynamic and abdominal motor reflexes elicited by neurotensin in anaesthetized guinea-pigs.
Topics: Animals; Atropine; Blood Pressure; Capsaicin; Cordotomy; Drug Interactions; Female; Guinea Pigs; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Morphine; Muscle Contraction; Naloxone; Neurotensin; Pentolinium Tartrate; Procaine; Reflex, Abdominal; Vagotomy | 1992 |
Antitussive effects of Ca2+ channel antagonists.
Topics: Animals; Antitussive Agents; Calcium Channel Blockers; Capsaicin; Codeine; Cough; Dextromethorphan; Drug Interactions; Drug Synergism; Flunarizine; Guinea Pigs; Male; Morphine; Nifedipine; Verapamil | 1992 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Cyclodextrins; Analgesia; Animals; beta-Cyclodextrins; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; Cyclodextrins; Dimethyl Sulfoxide; Electroencephalography; Enkephalin, Leucine-2-Alanine; gamma-Cyclodextrins; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Motor Activity; Naloxone; Narcotics; Pain; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Solubility; Substance P; Time Factors | 1991 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Hypothermia augments non-cholinergic neuronal bronchoconstriction in pithed guinea-pigs.
Topics: Adrenergic alpha-Agonists; Animals; Atropine; Azepines; Body Temperature; Bronchoconstriction; Capsaicin; Decerebrate State; Electric Stimulation; Guinea Pigs; Male; Morphine; Ouabain; Pentolinium Tartrate; Propranolol; Pyrilamine; Spinal Cord; Substance P; Sympathetic Nervous System; Tubocurarine | 1991 |
Airway hypocapnia increases microvascular leakage in the guinea pig trachea.
Topics: Animals; Capillary Permeability; Capsaicin; Carbon Dioxide; Evans Blue; Female; Glycopeptides; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Morphine; Tachykinins; Thromboxane-A Synthase; Trachea | 1992 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; Indomethacin; Inflammation; Mice; Morphine; Neurons; Pain; Spinal Cord | 1991 |
Further behavioral evidence that colorectal distension is a 'noxious' visceral stimulus in rats.
Topics: Animals; Avoidance Learning; Capsaicin; Colon; Inflammation; Male; Morphine; Motor Activity; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Rectum; Turpentine | 1991 |
Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Endothelins; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Morphine; Necrosis; Neuropeptides; Rats; Rats, Inbred Strains; Stomach Ulcer | 1991 |
Spinal evoked potential P2 wave elicited by C fiber input and depressed by analgesic factors.
Topics: Analgesia; Animals; Capsaicin; Electroacupuncture; Evoked Potentials; Foot; Hot Temperature; Injections, Spinal; Male; Morphine; Naloxone; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1991 |
Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine.
Topics: 5,7-Dihydroxytryptamine; Adenosine; Analgesia, Epidural; Analgesics; Animals; Capsaicin; Drug Administration Schedule; Drug Interactions; Hydroxydopamines; Injections, Spinal; Male; Morphine; Oxidopamine; Pain Measurement; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
Opioid agonists, prostaglandin E1 and clonidine modulate non-adrenergic, non-cholinergic transmission in the mammalian heart.
Topics: Adrenergic beta-Antagonists; Alprostadil; Animals; Atrial Function; Capsaicin; Clonidine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Morphine; Myocardial Contraction; Nerve Fibers | 1990 |
Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Morphine; Narcotics; Neurons; Nociceptors; Pressure; Rats; Rats, Inbred Strains; Time Factors; Vasodilation | 1990 |
Influence of the nervous system on experimentally induced urethral inflammation.
Topics: Adrenergic Fibers; Animals; Capsaicin; Female; Morphine; Nervous System; Neurons, Afferent; Rats; Rats, Inbred SHR; Urethritis | 1990 |
Morphine potentiation of ethanol-induced gastric mucosal damage in the rat. Role of local sensory afferent neurons.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Male; Morphine; Neurons, Afferent; Premedication; Rats; Rats, Inbred Strains | 1990 |
Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF.
Topics: Animals; Blood Pressure; Capsaicin; Female; Gastric Mucosa; Male; Microcirculation; Morphine; Naloxone; Platelet Activating Factor; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow | 1990 |
Does capsaicin cause reflex bronchospasm in guinea-pigs?
Topics: Animals; Autonomic Agents; Bronchial Spasm; Capsaicin; Female; Guinea Pigs; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Male; Morphine; Naloxone; Neurons, Afferent; Pulmonary Circulation; Reflex; Respiration; Substance P | 1985 |
Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin.
Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Pain; Substance P | 1985 |
Electrophysiological evidence for a presynaptic mechanism of morphine withdrawal in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; In Vitro Techniques; Membrane Potentials; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Substance Withdrawal Syndrome; Synapses | 1986 |
Neonatal capsaicin modifies morphine withdrawal signs in the rat.
Topics: Animals; Animals, Newborn; Capsaicin; Female; Male; Morphine; Naloxone; Nasal Mucosa; Rats; Rats, Inbred Strains; Salivation; Substance P; Substance Withdrawal Syndrome; Tears | 1986 |
Comparison of the bronchoconstrictor and cardiovascular effects of some tachykinins in guinea pigs.
Topics: Airway Resistance; Animals; Blood Pressure; Bronchi; Capsaicin; Eledoisin; Female; Guinea Pigs; Kinins; Male; Morphine; Physalaemin; Substance P | 1987 |
The acute effects of capsaicin on the cardiovascular system.
Topics: Animals; Blood Pressure; Capsaicin; Cardiovascular Physiological Phenomena; Cardiovascular System; Denervation; Heart Rate; Hexamethonium; Hexamethonium Compounds; Male; Morphine; Rats; Rats, Inbred Strains; Substance P; Vagus Nerve | 1987 |
Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Neonatal capsaicin treatment abolishes the modulations by opioids of substance P release from rat spinal cord slices.
Topics: Animals; Animals, Newborn; Capsaicin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Substance P | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
Captopril and capsaicin modify opioid withdrawal in the morphine-dependent rat.
Topics: Animals; Capsaicin; Captopril; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance P; Substance Withdrawal Syndrome | 1989 |
Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord.
Topics: Adenosine; Animals; Capsaicin; Hydroxydopamines; In Vitro Techniques; Male; Morphine; Neurons, Afferent; Norepinephrine; Oxidopamine; Potassium; Rats; Rats, Inbred Strains; Spinal Cord; Synaptosomes | 1989 |
Opioid inhibition of neurally mediated mucus secretion in human bronchi.
Topics: Aged; Bronchi; Capsaicin; Female; Fucose; Hexoses; Humans; Male; Middle Aged; Morphine; Mucus; Naloxone; Proteins; Random Allocation; Sensory Receptor Cells | 1989 |
Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms.
Topics: Animals; Atropine; Capsaicin; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Methysergide; Morphine; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Physostigmine; Serotonin; Serotonin Antagonists; Substance P; Tetrodotoxin; Tropisetron | 1985 |
Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf.
Topics: Animals; Capsaicin; Infusions, Intra-Arterial; Male; Morphine; Narcotics; Neurons, Afferent; Platelet Activating Factor; Rats; Rats, Inbred Strains; Stomach Ulcer; Tetrodotoxin | 1989 |
Peripheral receptors mediate the aversive conditioning effects of morphine in the rat.
Topics: Amphetamine; Animals; Capsaicin; Chlorides; Conditioning, Classical; Injections, Intraperitoneal; Lithium; Lithium Chloride; Male; Morphine; Naltrexone; Peritoneal Cavity; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
Morphine or capsaicin administration alters the secretion of beta-endorphin into the hypophysial portal vasculature of the rat.
Topics: Animals; beta-Endorphin; Capsaicin; Endorphins; Hypophysectomy; Male; Morphine; Naltrexone; Pituitary Gland; Portal System; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Analgesic effect of morphine: a role for beta-endorphin.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Endorphins; Injections, Intraventricular; Male; Morphine; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Sensory Thresholds | 1987 |
The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.
Topics: Animals; Apomorphine; Capsaicin; Dextromethorphan; In Vitro Techniques; Levallorphan; Lung; Morphine; Morphine Derivatives; Naloxone; Neurons, Afferent; Pentazocine; Rana catesbeiana; Receptors, Opioid | 1985 |
Hyperalgesia mediated by peripheral opiate receptors in the rat.
Topics: Administration, Topical; Animals; Behavior, Animal; Capsaicin; Etorphine; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs.
Topics: Animals; Capsaicin; Enkephalin, Methionine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Activity; Muscle Contraction; Substance Withdrawal Syndrome | 1988 |
[Effects of capsaicin on spontaneous unit discharges in amygdala single neurons of cats].
Topics: Action Potentials; Amygdala; Animals; Bradykinin; Brain Mapping; Capsaicin; Cats; Evoked Potentials; Female; Male; Morphine; Pain; Sensation | 1987 |
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Capsaicin; Ganglia, Spinal; Hypertension; Male; Morphine; Neurons, Afferent; Neurons, Efferent; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Sympathectomy; Sympathetic Nervous System | 1986 |
Evaluation of the analgesic effects of capsaicin using a new rat model for tonic pain.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Sensitivity of pulmonary chemo reflexes and lung inflation reflexes to repetitive stimulation and to inhibition with lidocaine and morphine.
Topics: Animals; Blood Gas Analysis; Capsaicin; Dogs; Female; Hemodynamics; Injections, Intra-Arterial; Lidocaine; Lung; Male; Morphine; Naloxone; Nerve Fibers; Pulmonary Artery; Reflex; Respiration | 1985 |
The effects of morphine, naloxone and capsaicin on C-fiber reflex and heat evoked discharge in acute spinal cats.
Topics: Animals; Capsaicin; Cats; Decerebrate State; Evoked Potentials; Female; Hot Temperature; Male; Morphine; Naloxone; Nerve Fibers; Reflex; Spinal Nerve Roots; Substance P | 1984 |
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.
Topics: Afferent Pathways; Animals; Capsaicin; Cats; Injections, Spinal; Morphine; Nociceptors; Pain; Potassium; Rats; Spinal Cord; Substance P | 1980 |
Characterization in guinea pigs of the sensory effects of the putative substance P neurotoxin capsaicin.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Guinea Pigs; Male; Morphine; Pain; Sensory Receptor Cells; Somatostatin; Substance P | 1981 |
Indirect evidence for the inhibition of enteric substance P neurones by opiate agonists but not by capsaicin.
Topics: Animals; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Female; Guinea Pigs; In Vitro Techniques; Intestines; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Neurons; Substance P; Synaptic Transmission | 1982 |
Intraventricular capsaicin: alterations in analgesic responsivity without depletion of substance P.
Topics: Animals; Brain; Capsaicin; Fatty Acids, Unsaturated; Injections, Intraventricular; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
Characterization of the peptide and sensory neurotoxic effects of capsaicin in the guinea pig.
Topics: Animals; Capsaicin; Cholecystokinin; Dose-Response Relationship, Drug; Ganglia, Spinal; Guinea Pigs; Morphine; Nerve Tissue Proteins; Nervous System Diseases; Neurons, Afferent; Nociceptors; Peripheral Nerves; Somatostatin; Spinal Cord; Substance P; Vasoactive Intestinal Peptide | 1983 |
Effects of prenatal capsaicin treatment on fetal spontaneous activity, opiate receptor binding, and acid phosphatase in the spinal cord.
Topics: Abnormalities, Drug-Induced; Acid Phosphatase; Animals; Capsaicin; Fatty Acids, Unsaturated; Female; Fetus; Maternal-Fetal Exchange; Morphine; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1982 |
Sensory neural mechanisms in contraction of the rabbit isolated sphincter pupillae: analysis of the responses to capsaicin and electrical field stimulation.
Topics: Animals; Atropine; Capsaicin; Carbachol; Denervation; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Morphine; Muscle Contraction; Neural Conduction; Pupil; Rabbits; Tetrodotoxin; Trigeminal Ganglion | 1984 |
Morphine tolerance and withdrawal in capsaicin--pretreated rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Capsaicin; Drug Tolerance; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1983 |
Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests.
Topics: Analgesia; Animals; Capsaicin; Formaldehyde; Male; Morphine; Pain; Peripheral Nerves; Rats; Sciatic Nerve; Time Factors | 1984 |
Capsaicin pretreatment interferes with the thermoregulatory effect of morphine.
Topics: Animals; Arousal; Body Temperature Regulation; Capsaicin; Fatty Acids, Unsaturated; Habituation, Psychophysiologic; Male; Morphine; Premedication; Rats; Rats, Inbred Strains | 1983 |
Antinociceptive actions of capsaicin in rodents.
Topics: Analgesics; Animals; Aspirin; Capsaicin; Fatty Acids, Unsaturated; Male; Mice; Morphine; Rats; Rats, Inbred Strains | 1983 |
[Effects of intra-arterially administered capsaicinoids on vocalization in guinea pigs and medial thalamic neuronal activity in cats (author's transl)].
Topics: Action Potentials; Animals; Aspirin; Capsaicin; Cats; Fatty Acids, Unsaturated; Guinea Pigs; Injections, Intra-Arterial; Male; Morphine; Neurons; Nociceptors; Tachyphylaxis; Thalamic Nuclei; Vocalization, Animal | 1982 |
Visceral pain reflex after pretreatment with capsaicin and morphine.
Topics: Anesthetics, Local; Animals; Blood Pressure; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Female; Male; Morphine; Muscle Contraction; Neurons, Afferent; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Vagotomy | 1982 |
Excitatory effects of dihydrocapsaicin on nociceptive neurons in the medial thalamus.
Topics: Action Potentials; Aged; Animals; Bradykinin; Capsaicin; Cats; Fatty Acids, Unsaturated; Humans; Morphine; Neurons; Nociceptors; Stimulation, Chemical; Tachyphylaxis; Thalamus | 1980 |
Pharmacology of the neurogenic oedema response to electrical stimulation of the saphenous nerve in the rat.
Topics: Amines; Animals; Bacitracin; Blood Pressure; Capsaicin; Edema; Electric Stimulation; Leg; Male; Mast Cells; Morphine; Neurons, Afferent; Rats | 1980 |
Effect of capsaicin on morphine analgesia--possible involvement of hypothalamic structures.
Topics: Animals; Animals, Newborn; Capsaicin; Fatty Acids, Unsaturated; Female; Hypothalamus; In Vitro Techniques; Male; Morphine; Pain; Rats | 1980 |
Evidence that capsaicin hyperaemia of rat sciatic vasa nervorum is local, opiate-sensitive and involves mast cells.
Topics: Afferent Pathways; Amino Acid Sequence; Animals; Capsaicin; Male; Mast Cells; Molecular Sequence Data; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Substance P; Vasa Nervorum | 1993 |
Capsaicin-induced bladder hyperactivity in normal conscious rats.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Compounds; Indoles; Isoindoles; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1994 |
Neonatal capsaicin treatment in rats results in scratching behavior with skin damage: potential model of non-painful dysesthesia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naloxone; Nerve Fibers; Rats; Rats, Sprague-Dawley; Self Mutilation; Skin; Substance P | 1994 |
Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1994 |
Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.
Topics: Animals; Antitussive Agents; Buprenorphine; Capsaicin; Cough; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid, mu; Time Factors | 1995 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes | 1993 |
Morphine modulates contractile responses and neurokinin A-LI release elicited by electrical field stimulation or capsaicin in a guinea pig bronchial-tube preparation.
Topics: Animals; Bronchoconstriction; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone; Neurokinin A | 1995 |
Blood pressure reflexes following activation of capsaicin-sensitive afferent neurones in the biliopancreatic duct of rats.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Bile Ducts, Extrahepatic; Blood Pressure; Capsaicin; Electric Stimulation; Female; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Pancreatic Ducts; Phentolamine; Rats; Rats, Sprague-Dawley; Reflex; Sympathectomy, Chemical | 1994 |
Antitussive effect of captopril, an angiotensin converting enzyme inhibitor, in the rat.
Topics: Animals; Antitussive Agents; Capsaicin; Captopril; Cough; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley | 1993 |
Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine.
Topics: Adenosine; Animals; Capsaicin; Dipyridamole; In Vitro Techniques; Male; Morphine; Norepinephrine; Nucleosides; Potassium; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Synaptosomes; Thioinosine | 1993 |
Induction of c-fos expression in spinal neurons by nociceptive and nonnociceptive stimulation of LUT.
Topics: Afferent Pathways; Animals; Capsaicin; Dizocilpine Maleate; Female; Gene Expression Regulation; Genes, fos; Morphine; Muscle Contraction; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Urinary Bladder | 1993 |
Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse.
Topics: Analgesics; Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Reaction Time; Receptors, Opioid, mu | 1993 |
Effects of excitatory amino acid receptor antagonists on a capsaicin-evoked nociceptive reflex: a comparison with morphine, clonidine and baclofen.
Topics: Animals; Baclofen; Capsaicin; Clonidine; Evoked Potentials; In Vitro Techniques; Morphine; Nociceptors; Rats; Receptors, Amino Acid; Reflex; Spinal Cord | 1993 |
Involvement of tachykinins in pentamidine-induced airway constriction and microvascular leakage in the guinea pig.
Topics: Aerosols; Albuterol; Analysis of Variance; Animals; Atropine; Bronchoconstriction; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Guinea Pigs; Male; Morphine; Neprilysin; Pentamidine; Tachykinins | 1993 |
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity | 1996 |
Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord.
Topics: Animals; Behavior, Animal; Capsaicin; Cystamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hormone Antagonists; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Narcotic Antagonists; Narcotics; Somatostatin; Spinal Cord; Substance P; Tachykinins | 1996 |
Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat.
Topics: Animals; Animals, Newborn; Autonomic Nervous System; Capsaicin; Gastrointestinal Motility; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome; Weight Loss | 1997 |
Peripherally administrated morphine attenuates capsaicin-induced mechanical hypersensitivity in humans.
Topics: Adult; Aged; Capsaicin; Female; Humans; Male; Mechanoreceptors; Middle Aged; Morphine; Pain; Peripheral Nervous System; Receptors, Opioid; Time Factors | 1997 |
Characterization of an esophagocardiovascular reflex in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Blood Pressure; Capsaicin; Cardiovascular Physiological Phenomena; Cardiovascular System; Catheterization; Esophageal Diseases; Esophagus; Heart Rate; Imidazoles; Injections, Spinal; Male; Medetomidine; Morphine; Narcotics; Paralysis; Rats; Rats, Sprague-Dawley; Reflex; Vagus Nerve | 1997 |
Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Colic; Dose-Response Relationship, Drug; Indomethacin; Male; Morphine; Pain; Peritoneum; Prostaglandins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Viscera | 1997 |
Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence.
Topics: Administration, Cutaneous; Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Female; Hot Temperature; Morphine; Nerve Fibers; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Skin Temperature | 1996 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Formaldehyde; Inflammation; Male; Meloxicam; Mice; Morphine; Muscle Contraction; Pain; Pain Measurement; Reaction Time; Thiazines; Thiazoles | 1998 |
Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents.
Topics: Afferent Pathways; Animals; Brain Stem; Capsaicin; Female; Gastric Acid; Gastric Mucosa; Genes, fos; Hydrochloric Acid; Instillation, Drug; Morphine; Naloxone; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Spinal Cord; Transcription, Genetic; Vagus Nerve | 1998 |
A novel method for detecting the analgesic effect of drugs by quantifying body movement after noxious stimulation in neonatal rat.
Topics: Analgesics; Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Morphine; Movement; Naloxone; Narcotic Antagonists; Nociceptors; Noise; Pain Measurement; Pregnancy; Rats; Rats, Wistar; Stimulation, Chemical | 1998 |
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Female; Formaldehyde; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pain Measurement; Piperidines; Plants, Medicinal; Postural Balance; Reaction Time; Vas Deferens | 1999 |
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
In vivo effects of the NMDA receptor agonist tetrazolyl-glycine related to the function of small-diameter primary afferents.
Topics: Afferent Pathways; Anesthesia; Animals; Blood Pressure; Capillary Permeability; Capsaicin; Decerebrate State; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Glycine; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Skin; Tetrazoles | 1999 |
Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Male; Morphine; Nerve Fibers; Neurons, Afferent; Potassium; Rats; Rats, Sprague-Dawley; Substance P | 1999 |
Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Consciousness; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; Morphine; Nerve Fibers; Nociceptin; Nociceptors; Opioid Peptides; Pain; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Substance P; Time Factors; Vasodilator Agents | 2000 |
The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdomen; Animals; Animals, Newborn; Antiemetics; Behavior, Animal; Capsaicin; Cisplatin; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Motion Sickness; Nicotine; Piperidines; Proto-Oncogene Proteins c-fos; Serotonin Receptor Agonists; Shrews; Tropisetron; Vagotomy; Vomiting | 2000 |
Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine.
Topics: Analgesics, Opioid; Animals; Capsaicin; Electrophysiology; Ganglionic Stimulants; Histamine; Hot Temperature; Injections, Intradermal; Irritants; Male; Morphine; Nicotine; Nociceptors; Posterior Horn Cells; Pruritus; Rats; Rats, Sprague-Dawley; Reaction Time; Stimulation, Chemical; Tachyphylaxis | 2000 |
Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Analgesics, Opioid; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Neurons, Afferent; Neuroprotective Agents; Oligopeptides; Pain; Pertussis Toxin; Piperidines; Protease Inhibitors; Purinergic Agonists; Thionucleosides; Time Factors; Virulence Factors, Bordetella | 2000 |
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Freund's Adjuvant; Hyperalgesia; Ketorolac; Macaca mulatta; Male; Morphine; Pain; Pain Measurement; Piperazines; Receptors, Opioid, delta | 2001 |
Neurometer measurement of current stimulus threshold in rats.
Topics: Animals; Capsaicin; Diazepam; Electric Stimulation; Male; Morphine; Nerve Fibers; Pain Threshold; Rats; Rats, Sprague-Dawley | 2001 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
A new model of visceral pain and referred hyperalgesia in the mouse.
Topics: Abdomen; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Female; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Mustard Plant; Pain; Plant Extracts; Plant Oils; Touch | 2001 |
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Male; Mecamylamine; Morphine; Narcotics; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse.
Topics: Analgesics, Opioid; Animals; Calcium Channels; Capsaicin; Cell Size; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; GTP-Binding Proteins; Lectins; Male; Mice; Mice, Inbred C57BL; Morphine; Neurons, Afferent; Nociceptin; Nociceptors; Opioid Peptides; Patch-Clamp Techniques; Trigeminal Ganglion; Vasodilator Agents; Virulence Factors, Bordetella | 2001 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Disease Models, Animal; Drug Interactions; Female; Formaldehyde; Gingiva; Inflammation; Male; Meloxicam; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Toothache | 2002 |
The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine.
Topics: Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Grooming; Injections, Subcutaneous; Male; Morphine; Nociceptors; Rats; Rats, Sprague-Dawley; Vibrissae | 2002 |
Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats.
Topics: Animals; Capsaicin; Dopamine; Dopamine Antagonists; Drug Administration Routes; Drug Implants; Drug Tolerance; Extracellular Space; Male; Microdialysis; Microinjections; Morphine; Nicotinic Antagonists; Nucleus Accumbens; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex | 2002 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium | 2003 |
A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Hyperalgesia; Ligation; Male; Meloxicam; Morphine; Pain; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazines; Thiazoles; Thymic Factor, Circulating; Time Factors | 2003 |
Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Dose-Response Relationship, Drug; Escape Reaction; Female; Hot Temperature; Hyperalgesia; Immunotoxins; Injections, Spinal; Morphine; Pain Measurement; Rats; Rats, Long-Evans; Reaction Time; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2003 |
Blockade of nociceptive inhibition of plasma extravasation by opioid stimulation of the periaqueductal gray and its interaction with vagus-induced inhibition in the rat.
Topics: Adrenal Medulla; Animals; Capillary Permeability; Capsaicin; Denervation; Efferent Pathways; Epinephrine; Functional Laterality; Knee Joint; Male; Medulla Oblongata; Models, Neurological; Morphine; Neural Inhibition; Neurogenic Inflammation; Nociceptors; Periaqueductal Gray; Plasma; Rats; Rats, Sprague-Dawley; Reaction Time; Vagus Nerve; Vagus Nerve Injuries; Vasoconstriction | 2003 |
[Pain and QOL--morphine-tolerance and morphine-resistant neuropathic pain].
Topics: Adrenergic alpha-Antagonists; Capsaicin; Drug Resistance; Drug Therapy, Combination; Drug Tolerance; Humans; Morphine; Neoplasms; Neuralgia; Phentolamine; Protein Kinase C; Quality of Life; Receptor, trkB; Receptors, N-Methyl-D-Aspartate | 2003 |
Antitussive activity of Anar.
Topics: Animals; Antibodies; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Lung; Male; Morphine | 2003 |
Capsaicin-induced hyperalgesia and mu-opioid-induced antihyperalgesia in male and female Fischer 344 rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Capsaicin; Clinical Trials as Topic; Cycloparaffins; Disease Models, Animal; Female; Humans; Hyperalgesia; Male; Morphine; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2003 |
Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Facial Pain; Ketamine; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley | 2003 |
An assessment of vascular pain using the flexor reflex in anesthetized rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electromyography; Hindlimb; Injections, Intra-Arterial; Injections, Spinal; Injections, Subcutaneous; Lidocaine; Male; Morphine; Muscle, Skeletal; Naloxone; Pain Measurement; Procaine; Rats; Rats, Sprague-Dawley; Reflex, Stretch; Time Factors; Toes; Vascular Diseases | 2004 |
Opioid receptor desensitization contributes to thermal hyperalgesia in infant rats.
Topics: Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Female; Hyperalgesia; Morphine; Narcotic Antagonists; Pain Measurement; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid; Touch | 2004 |
Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.
Topics: Animals; Avian Sarcoma Viruses; Capsaicin; Cell Line, Transformed; Cell Line, Tumor; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Fibroblasts; Genetic Vectors; Hindlimb; Hyperalgesia; Inflammation; Male; Mice; Morphine; Neoplasm Regression, Spontaneous; Neoplasm Transplantation; Nociceptors; Oligopeptides; Pain Measurement; Peptides, Cyclic; Piperidines; Rats; Reaction Time; Receptors, Endothelin | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
Differential activation of trigeminal C or Adelta nociceptors by infrared diode laser in rats: behavioral evidence.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dimethyl Sulfoxide; Hot Temperature; Infrared Rays; Lasers; Male; Morphine; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Trigeminal Nerve | 2005 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Capsaicin; Carrageenan; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enkephalin, D-Penicillamine (2,5)-; Extravasation of Diagnostic and Therapeutic Materials; Fentanyl; Hindlimb; Histamine Antagonists; Inflammation; Male; Morphine; Narcotic Antagonists; Oxidopamine; p-Methoxy-N-methylphenethylamine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Lumbosacral Region; Male; Mononeuropathies; Morphine; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Nerves | 2006 |
Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Hyperalgesia; Macaca; Morphine; Nociceptors; Reaction Time; Simplexvirus; Skin | 2006 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction | 2006 |
Neurochemical changes in the RVM associated with peripheral inflammatory pain stimuli.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Capsaicin; Chromatography, High Pressure Liquid; Dinoprostone; Drug Interactions; Electrochemistry; Hot Temperature; Male; Medulla Oblongata; Microdialysis; Morphine; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.
Topics: Analysis of Variance; Animals; Benzothiazoles; Brain; Capsaicin; Drug Synergism; Ganglia, Spinal; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Touch | 2006 |
The effects of pH on beta-endorphin and morphine inhibition of calcium transients in dorsal root ganglion neurons.
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Calcium Signaling; Capsaicin; Cells, Cultured; Drug Interactions; Extracellular Fluid; Ganglia, Spinal; Hydrogen-Ion Concentration; Inflammation; Intracellular Fluid; Male; Morphine; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Potassium; Rats; Rats, Wistar; Receptors, Opioid | 2006 |
The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway.
Topics: Capsaicin; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Morphine; Phosphorylation; Receptors, Opioid, mu; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; TRPV Cation Channels | 2006 |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine | 2006 |
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Drug Administration Schedule; Endocannabinoids; Ganglia, Spinal; Hot Temperature; Immunologic Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid-Related Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2006 |
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Facial Pain; Formaldehyde; Lip; Male; Mice; Morphine; Narcotics; Nociceptors; Pain Measurement; Psychomotor Performance; Trigeminal Nerve | 2006 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Opioid; Ruthenium Red; Signal Transduction; Snails; TRPV Cation Channels | 2007 |
Dragon's blood from Croton urucurana (Baill.) attenuates visceral nociception in mice.
Topics: Abdominal Pain; Acetylcysteine; Administration, Oral; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Capsaicin; Clonidine; Croton; Cyclophosphamide; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Pentobarbital; Plant Extracts; Sleep; Time Factors | 2007 |
Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol.
Topics: Acetaldehyde; Analgesics, Opioid; Calcium; Capsaicin; Cell Line; Central Nervous System Depressants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Drug Synergism; Estrenes; Ethanol; Humans; Ion Channel Gating; Kidney; Morphine; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Radioligand Assay; Sensory System Agents; Tritium; TRPV Cation Channels | 2008 |
Antinociceptive activity of n-butanol fraction from MeOH extracts of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Constriction, Pathologic; Formaldehyde; Hot Temperature; Hypnotics and Sedatives; Methanol; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2007 |
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.
Topics: Acute Disease; Analgesics, Opioid; Animals; Capsaicin; Data Interpretation, Statistical; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hot Temperature; Hyperalgesia; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Inbred F344; Sex Characteristics | 2008 |
Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves.
Topics: Acetic Acid; Acetone; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Ellagic Acid; Formaldehyde; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Methanol; Mice; Morphine; Myrtaceae; Pain Measurement; Phenols; Plant Extracts; Plant Leaves; Solvents | 2008 |
Counteracting effect of papaverine on morphine inhibition of gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Constipation; Dexamethasone; Enzyme Inhibitors; Gastrointestinal Transit; Glucocorticoids; Humans; Indomethacin; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Papaverine; Sensory System Agents | 2008 |
Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Foot Diseases; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Neoplasms, Experimental; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred F344; Ruthenium Red; TRPV Cation Channels | 2008 |
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision.
Topics: Acrylamides; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Male; Morphine; Pain, Postoperative; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2008 |
Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons.
Topics: Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Neurons, Afferent; Pain Measurement; Pain Threshold; Receptors, Opioid, mu; Sensory System Agents; Simplexvirus | 2008 |
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Galanin; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Narcotics; Nerve Fibers, Unmyelinated; Neuroblastoma; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical; Sulfonamides; TRPV Cation Channels | 2008 |
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Resistance; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Glycine; Hyperalgesia; Male; Morphine; Nonlinear Dynamics; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine | 2009 |
Inflammatory mediators released following application of irritants on the rat injured incisors. The effect of treatment with anti-inflammatory drugs.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Capsaicin; Celecoxib; Dexamethasone; Dinoprostone; Endotoxins; Incisor; Indomethacin; Inflammation Mediators; Irritants; Morphine; Nerve Growth Factor; Pyrazoles; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sulfonamides | 2009 |
Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Histamine; Injections, Intradermal; Mice; Morphine; Naltrexone; Oligopeptides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Proteinase-Activated; Serotonin; Spinal Cord; Tachyphylaxis | 2009 |
High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors.
Topics: Acrolein; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Dose-Response Relationship, Drug; Extremities; Ganglia, Spinal; Hot Temperature; Humans; Ion Channel Gating; Mice; Morphine; Naloxone; Neurons; Skin; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2009 |
Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Morphine; Narcotics; Pain Measurement; Pain Threshold; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; TRPV Cation Channels; Water Deprivation | 2009 |
Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Body Temperature; Capsaicin; Formaldehyde; Glucosides; Hot Temperature; Hypnotics and Sedatives; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2009 |
Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression.
Topics: Animals; Capsaicin; Gene Expression Regulation; Male; Morphine; Neurokinin A; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Wound Healing; Wounds and Injuries | 2009 |
Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Ganglia, Spinal; Indoles; Morphine; Phenols; Proto-Oncogene Proteins c-raf; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sensory Receptor Cells; TRPV Cation Channels | 2009 |
Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments.
Topics: Animals; Antibodies; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Glycopeptides; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Neprilysin; Pain; Pain Measurement; Peptide Fragments; Protease Inhibitors; Spinal Cord; Substance P | 2009 |
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels.
Topics: Acetanilides; Animals; Capsaicin; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation; Isothiocyanates; Mice; Morphine; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Purines; Signal Transduction; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamates; Male; Mice; Monoterpenes; Morphine; Motor Activity; Narcotics; Neural Conduction; Nociceptors; Pain; Rats; Rats, Wistar; Sciatic Nerve; Sensory System Agents | 2010 |
Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; TRPV Cation Channels | 2010 |
Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bupivacaine; Capsaicin; Ganglia, Spinal; Indomethacin; Inflammation; Male; Morphine; Neurons; Pain; Pain Measurement; Patch-Clamp Techniques; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Sodium Channel Blockers | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Irritants; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Mucuna; Naltrexone; Narcotic Antagonists; Pain; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Thrombin; Time Factors | 2010 |
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Genetic Therapy; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Morphine; Narcotics; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Second Messenger Systems; Spinal Cord; Stress, Mechanical | 2011 |
Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicum in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Temperature; Capsaicin; Chrysanthemum; Ethanol; Ethers; Hot Temperature; Hypnotics and Sedatives; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Sleep; Solvents; Water | 2011 |
Capsaicin induces reflex scratching in inflamed skin.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Freund's Adjuvant; Inflammation; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Pain; Pruritus; Receptors, Opioid, mu; Reflex; Sensory System Agents; Skin; Time Factors; TRPV Cation Channels | 2011 |
Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Inflammation; Male; Morphine; Narcotics; Pain; Pain Measurement; Pyridines; Quinolines; Rats; Rats, Inbred F344; Receptors, Metabotropic Glutamate | 2011 |
Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia.
Topics: Action Potentials; Analgesics, Opioid; Animals; Capsaicin; Ganglia, Spinal; Male; Membrane Potentials; Mice; Morphine; Nociception; RNA, Messenger; Sensory Receptor Cells; Sodium; Sodium Channels; Tetrodotoxin; TRPV Cation Channels | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity.
Topics: Adiponectin; Animals; Capsaicin; Carrageenan; Down-Regulation; Edema; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Morphine; Nitric Oxide Synthase Type II; Nociception; Obesity; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; Receptors, Leptin; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Capsaicin; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Morphine; Oxycodone; Skin; Treatment Outcome; Ultraviolet Rays | 2012 |
Hyptis pectinata: redox protection and orofacial antinociception.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Facial Pain; Free Radical Scavengers; Glutamic Acid; Hyptis; Lipid Peroxidation; Male; Mice; Morphine; Pain Measurement; Picrates; Plant Extracts; Plant Leaves; Thiobarbituric Acid Reactive Substances | 2013 |
Role of capsaicin in a murine model of labor and delivery.
Topics: Analgesia, Obstetrical; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Delivery, Obstetric; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Labor Pain; Labor, Obstetric; Mice; Mice, Inbred C57BL; Morphine; Pregnancy; Pregnancy Outcome; Proteomics; Weight Gain | 2013 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Morphine; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Opioid, mu; Sensory Receptor Cells; Substance Withdrawal Syndrome; Tritium; TRPV Cation Channels | 2013 |
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Catheterization; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Synaptic Transmission | 2013 |
β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Lippia; Male; Mice; Morphine; Nociception; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Leaves | 2014 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
The effects of juvenile capsaicin desensitization in rats: behavioral impairments.
Topics: Animals; Body Temperature; Body Temperature Regulation; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine; Motor Activity; Nociceptive Pain; Organ Size; Pain Threshold; Rats; Recognition, Psychology; Schizophrenia; Sensory Gating; TRPV Cation Channels; Urinary Bladder | 2014 |
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociception; Pain; Protons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; TRPV Cation Channels | 2014 |
Tapentadol inhibits calcitonin gene-related peptide release from rat brainstem in vitro.
Topics: Animals; Brain Stem; Calcitonin Gene-Related Peptide; Capsaicin; Male; Morphine; Morpholines; Phenols; Potassium; Rats; Rats, Wistar; Reboxetine; Tapentadol | 2014 |
Blocking TRPV1 in nucleus accumbens inhibits persistent morphine conditioned place preference expression in rats.
Topics: Animals; Blotting, Western; Capsaicin; Craving; Dose-Response Relationship, Drug; Male; Microscopy, Immunoelectron; Morphine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Spatial Behavior; TRPV Cation Channels | 2014 |
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
Topics: Analgesics, Opioid; Animals; Capsaicin; Conditioning, Operant; Equipment Design; Facial Pain; Female; Hyperalgesia; Morphine; Pain Measurement; Pressure; Rats, Sprague-Dawley; Touch | 2015 |
Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.
Topics: Animals; Capsaicin; Diffuse Noxious Inhibitory Control; Heat-Shock Response; Hyperalgesia; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley | 2016 |
Enhancement of orofacial antinociceptive effect of carvacrol, a monoterpene present in oregano and thyme oils, by β-cyclodextrin inclusion complex in mice.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Cymenes; Diazepam; Facial Pain; Hand Strength; Male; Mice; Monoterpenes; Morphine; Nociception; Origanum; Pain Measurement; Thymus Plant | 2016 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Effects of Tetrodotoxin in Mouse Models of Visceral Pain.
Topics: Analgesics; Animals; Capsaicin; Colon; Cystitis; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Knockout; Morphine; Mustard Plant; Nociceptors; Pain Measurement; Plant Oils; Sodium Channels; Tetrodotoxin; Visceral Pain | 2017 |
G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons.
Topics: Analgesics, Opioid; Animals; Baclofen; Calcium; Capsaicin; CHO Cells; Cricetulus; Electrophysiology; Female; Ganglia, Spinal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Humans; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pain Measurement; Phosphatidylinositols; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; TRPM Cation Channels | 2017 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
A novel visceral pain model of uterine cervix inflammation in rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Female; Injections, Spinal; Morphine; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Uterine Cervicitis; Visceral Pain | 2021 |
Postinjury stimulation triggers a transition to nociplastic pain in mice.
Topics: Animals; Capsaicin; Chronic Pain; Female; Humans; Hyperalgesia; Male; Mice; Morphine; Pain Measurement | 2022 |
Analyzing the Antinociceptive Effect of Interleukin-31 in Mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Interleukins; Mice; Morphine; Pain | 2023 |