capsaicin has been researched along with capsazepine in 721 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 80 (11.10) | 18.2507 |
| 2000's | 352 (48.82) | 29.6817 |
| 2010's | 266 (36.89) | 24.3611 |
| 2020's | 23 (3.19) | 2.80 |
| Authors | Studies |
|---|---|
| Bevan, S; Boelsterli, JJ; Bovermann, G; Breckenridge, R; Davies, JW; Hughes, GA; James, I; Oberer, L; Walpole, CS; Winter, J | 1 |
| Annunziata, R; Appendino, G; Cravotto, G; Palmisano, G; Szallasi, A | 1 |
| Blumberg, PM; Choi, HK; Ha, HJ; Kang, M; Kang, SU; Kim, HD; Kim, JM; Kim, YH; Lee, J; Lim, JO; Lundberg, DJ; Oh, U; Park, HG; Park, YH; Pearce, LV; Shin, M; Suh, YG; Toth, A; Tran, R; Wang, Y | 1 |
| Cho, H; Choi, JY; Choi, SH; Jew, SS; Kang, SU; Kim, HD; Kyu Choi, J; Lee, J; Oh, U; Park, HG; Park, MK; Park, YH; Su Jeong, Y; Suh, YG | 1 |
| Bogenstaetter, M; Breitenbucher, JG; Carruthers, NI; Chang, L; Chaplan, SR; Codd, EE; Dax, SL; Dubin, AE; Gonzales, L; Hoey, K; Jetter, M; Lee, DH; Liu, C; Lord, B; Mazur, C; Nasser, N; Rizzolio, M; Shah, C; Swanson, DM; Zhang, SP | 1 |
| Bianchi, BR; El Kouhen, R; Faltynek, CR; Gomtsyan, A; Jarvis, MF; Lee, CH; McDonald, HA; Moreland, RB; Neelands, TR; Puttfarcken, PS; Raja, SN; Surber, B; Surowy, CS; Vaidyanathan, SN | 1 |
| Correa, EA; Echeverri, F; Högestätt, ED; Sterner, O; Zygmunt, PM | 1 |
| Horie, S; Takayama, H; Terada, Y; Tominaga, M; Uchida, K; Watanabe, T | 1 |
| Lou, YP; Lundberg, JM | 1 |
| Dray, A | 2 |
| Lee, LY; Lou, YP; Lundberg, JM; Satoh, H | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, D | 1 |
| Campbell, EA; Perkins, MN | 1 |
| Bevan, S; Hothi, S; Hughes, G; James, IF; Rang, HP; Shah, K; Walpole, CS; Yeats, JC | 1 |
| Franco-Cereceda, A; Lundberg, JM | 1 |
| Dickenson, AH | 1 |
| Dray, A; Urban, L | 1 |
| Dickenson, AH; Dray, A | 1 |
| Håkanson, R; Wang, ZY | 1 |
| Kuraishi, Y; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Goso, C; Manzini, S; Szallasi, A | 1 |
| Barnes, PJ; Dray, A; Fox, AJ; Urban, L | 1 |
| Baker, J; Bertrand, C; Geppetti, P; Nadel, JA; Piedimonte, G; Yamawaki, I | 1 |
| Bevan, S; Giuliani, S; Maggi, CA; Rang, HP; Walpole, CS | 1 |
| Bevan, S; Burgess, GM; Cholewinski, A | 1 |
| Goso, C; Szallasi, A | 1 |
| Acs, G; Blumberg, PM; Palkovits, M | 2 |
| Lee, LY; Lundberg, JM | 1 |
| Kuraishi, Y; Satoh, M; Ueda, M | 1 |
| Franco-Cereceda, A; Källner, G; Lundberg, JM | 2 |
| Delay-Goyet, P; Lundberg, JM; Satoh, H | 1 |
| Bevan, S; Del Bianco, E; Figini, M; Maggi, CA; Santicioli, P | 1 |
| Blumberg, PM; Goso, C; Manzini, S; Szallasi, A | 1 |
| Blumberg, PM; Evangelista, S; Goso, C; Manzini, S; Szallasi, A; Tramontana, M | 1 |
| Ellis, JL; Undem, BJ | 1 |
| Dray, A; Seno, N | 1 |
| Lou, YP; Lundberg, JM; Satoh, H | 1 |
| Barnes, PJ; Belvisi, MG; Chung, KF; Fox, AJ; Lalloo, UG | 1 |
| Colquhoun, EQ; Eldershaw, TP; Geraghty, DP; Griffiths, CD; Hall, JL | 1 |
| Furey, G; Sanger, GJ; Wardle, KA | 1 |
| Hwang, SW; Kim, D; Oh, U | 1 |
| Szallasi, A | 1 |
| Hua, XY; Jinno, S; Wong, S; Yaksh, TL | 1 |
| Blumberg, PM; Hökfelt, T; Lundberg, JM; Nilsson, S; Szallasi, A | 1 |
| Dale, N; Kuenzi, FM | 1 |
| Ellis, JL; Sham, JS; Undem, BJ | 1 |
| Belmonte, C; Chen, X; Rang, HP | 1 |
| Ohkubo, T; Shibata, M | 1 |
| Chen, I; Liu, L; Lo, Y; Simon, SA | 1 |
| Czachurski, J; Seller, H; Zanzinger, J | 1 |
| Liu, L; Simon, SA | 2 |
| Chen, P; Hua, XY; Hwang, J; Yaksh, TL | 1 |
| Arguelles, JH; Baumann, TK; Martenson, ME | 1 |
| Docherty, RJ; Piper, AS; Yeats, JC | 1 |
| Kitamura, K; Ohkubo, T | 1 |
| Calixto, JB; Santos, AR | 1 |
| Flores, CM; Harding-Rose, C; Hargreaves, KM; Kilo, S | 1 |
| Knotková-Urbancová, H; Kress, M; Reeh, PW; Vitásková, Z; Vlachová, V; Vyklický, L | 1 |
| Bowen, WP; Grattan, TJ; Morice, AH; Wright, CE | 1 |
| Liu, L; Simon, SA; Szallasi, A | 1 |
| Acs, P; Bíró, T; Blumberg, PM; Brodie, C; Lewin, NE; Modarres, S | 1 |
| Bast, A; den Hartog, GJ; van Bree, L; van Hoof, HJ; Voss, HP | 1 |
| Lopshire, JC; Nicol, GD | 1 |
| Schultz, HD; Ustinova, EE | 1 |
| Iwata, F; Lam, K; Leung, FW; Leung, JW; Seno, K | 1 |
| Cho, TS; Jung, YS; Moon, CH; Shin, HS | 1 |
| Hwang, SW; Jung, JY; Kwak, JY; Lee, WT; Oh, U | 1 |
| Harrison, S; Page, CP; Reddy, S; Spina, D | 1 |
| Beltramo, M; Piomelli, D | 1 |
| Fushiki, T; Inoue, K; Ishihara, K; Kawada, T; Kim, KM | 1 |
| Fisher, JT; Nault, MA; Vincent, SG | 1 |
| Lee, SS; Park, YH; Surh, YJ | 1 |
| Cho, TS; Jung, YS; Lee, B; Lee, SM; Moon, CH; Shin, HS | 1 |
| Bíró, T; Blumberg, PM; Klusch, A; Krause, JE; Modarres, S; Petersen, M; Sterner, O; Szabó, T; Szallasi, A | 1 |
| Furue, H; Kumamoto, E; Li, YQ; Yang, K; Yoshimura, M | 1 |
| Geraghty, DP; Mazzone, SB | 1 |
| Averbeck, B; Bove, GM; Reeh, PW; Sauer, SK | 1 |
| Andersson, DA; Chuang, H; Di Marzo, V; Högestätt, ED; Julius, D; Petersson, J; Sørgård, M; Zygmunt, PM | 1 |
| Akiba, Y; Engel, E; Guth, PH; Kaunitz, JD; Nastaskin, I | 1 |
| Annicelli, LL; Blumberg, PM; Cortright, DN; Krause, JE; Szallasi, A | 1 |
| Nagy, I; Rang, HP | 1 |
| Büsselberg, D; Greffrath, W; Kirschstein, T; Treede, RD | 1 |
| Mustafa, S; Oriowo, MA | 1 |
| Clothier, RH; Downing, AT; Fry, JR; Garle, MJ; Jassi, KL; Knight, A | 1 |
| Auberson, S; Lacroix, JS; Lundberg, JM | 1 |
| Jerman, JC; Smart, D | 1 |
| Distler, C; Habelt, C; Kessler, F; Kress, M; Reeh, PW | 1 |
| Carratú, MR; Cochereau, C; Creppy, EE; Cuomo, V; Ennamany, R; Richeux, F; Saboureau, D | 1 |
| Cho, H; Cho, S; Hwang, SW; Jung, J; Kang, CJ; Kim, D; Kwak, J; Lee, SY; Min, KH; Oh, U; Suh, YG | 1 |
| Davis, JB; Gunthorpe, MJ; Harries, MH; Prinjha, RK; Randall, A | 1 |
| Averbeck, B; Izydorczyk, I; Kress, M | 1 |
| Brough, SJ; Davis, JB; Harries, MH; Jerman, JC; Prinjha, R; Smart, D | 1 |
| Antunes, E; Costa, SK; da Silva, GR; Linardi, A | 1 |
| Klusch, A; Marín-Burgin, A; Petersen, M; Reppenhagen, S; Wendland, JR | 1 |
| Kim, JA; Lee, YS; Nam, DH | 1 |
| Colquhoun, EQ; Geraghty, DP; Griffiths, CD; Szallasi, A; Vincent, MA | 1 |
| Buchheit, KH; Campbell, EA; Chaudhry, N; James, IF; Kane, S; Panesar, M; Patel, S; Sandells, B; Urban, L | 1 |
| Bielefeldt, K | 1 |
| Bowles, WR; Engeland, WC; Guo, A; Harding-Rose, CA; Ulrich-Lai, YM | 1 |
| Chessell, IP; Gauldie, SD; McQueen, DS; Pertwee, R | 1 |
| Brockie, HC; Craib, SJ; Di Marzo, V; Gibson, TM; Leslie, M; Pashmi, G; Pertwee, RG; Ross, RA | 1 |
| Amadesi, S; Bianchi, A; Carreras, M; Creminon, C; Geppetti, P; Harrison, S; Matera, M; Tognetto, M; Trevisani, M | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Akiba, Y; Engel, E; Furukawa, O; Guth, PH; Kaunitz, JD; Nastaskin, I | 1 |
| Bevan, S; Chambers, A; Clarke, M; James, IF; McIntyre, P; McLatchie, LM; Peacock, M; Phillips, E; Rang, HP; Savidge, J; Shah, K; Toms, C; Webb, M; Weerasakera, N; Winter, J | 1 |
| Ranasinghe, SP; Rang, HP; Savidge, JR | 1 |
| Brough, SJ; Cairns, W; Davis, JB; Gunthorpe, MJ; Hayes, PD; Jerman, JC; Randall, AD; Ranson, J; Smart, D | 1 |
| Chung, HT; Kim, IK; Kim, NY; Oh, GS; Pae, HO; Pyun, KH; Seo, WG; Shin, M | 1 |
| Ahn, D; Kwon, S; Lee, Y; Leem, J; Nam, T; Yeon, D | 1 |
| Rudd, JA; Wai, MK | 1 |
| Harrison, C; Lambert, DG; Rowbotham, DJ; Smart, D; Sprague, J | 1 |
| Eun, SY; Jung, SJ; Kim, J; Kim, SJ; Kwak, J; Park, YK | 1 |
| Baumann, TK; Chaudhary, P; Martenson, ME | 1 |
| McVey, DC; Vigna, SR | 1 |
| Craib, SJ; Ellington, HC; Pertwee, RG; Ross, RA | 1 |
| Erbelding, D; Kilbinger, H; Mang, CF | 1 |
| Kohama, K; Nakamura, A; Shirakura, K; Sudo, M; Takagishi, K; Tomioka, A; Tsutsumi, S | 1 |
| Bisogno, T; Brandi, I; Davis, JB; De Petrocellis, L; Di Marzo, V; Hanus, L; Mechoulam, R; Moriello, AS; Ponde, DE; Tchilibon, S | 1 |
| Bottrill, FE; Ford, WR; Hiley, CR; Ho, WS; White, R | 1 |
| Liddle, RA; McVey, DC; Nathan, JD; Patel, AA; Prpic, V; Thomas, JE; Vigna, SR | 1 |
| Boachie-Ansah, G; Grainger, J | 1 |
| Dussor, GO; Flores, CM; Harding-Rose, C; Hargreaves, KM; Kilo, S; Leong, AS | 1 |
| Horie, S; Minowa, S; Murayama, T; Tsuchiya, S; Watanabe, K | 1 |
| Bove, GM; Reeh, PW; Sauer, SK | 1 |
| Fowler, CJ; Jacobsson, SO; Wallin, T | 1 |
| Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A | 1 |
| Fushiki, T; Haramizu, S; Ohnluki, K; Watanabe, T; Yazawa, S | 1 |
| Kobata, K; Sakurada, N; Watanabe, T | 1 |
| Denda, M; Denda, S; Fuziwara, S; Inoue, K; Koizumi, S | 1 |
| Biro, T; Blumberg, PM; Gonzalez, AF; Palkovits, M; Szabo, T | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Nocerino, E; Pinto, A; Sautebin, L | 1 |
| Ahluwalia, A; Aston, D; McLean, PG; Sarkar, D | 1 |
| Kim, KH | 1 |
| Lee, LY; Lin, YS | 1 |
| Berrino, L; Cuomo, D; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F | 1 |
| Kakehi, K; Kawabata, A; Kinoshita, M; Kuroda, R | 1 |
| Amadesi, S; Barbieri, M; Bianchi, A; Brough, SJ; Campi, B; Davis, JB; Geppetti, P; Gray, J; Gunthorpe, MJ; Harrison, S; Jerman, JC; Owen, D; Randall, AD; Smart, D; Smith, GD; Tognetto, M; Trevisani, M | 1 |
| Kagawa, S; Kato, S; Nakashima, M; Takeuchi, K; Tashima, K | 1 |
| Andersson, DA; Bevan, S; Colley, S; Earley, TJ; Hergarden, AC; Hogenesch, JB; McIntyre, P; Moqrich, A; Patapoutian, A; Peier, AM; Reeve, AJ; Story, GM | 1 |
| Harada, N; Katsuragi, T; Okajima, K; Uchiba, M | 1 |
| Berger, AL; Price, MP; Welsh, MJ; Xie, J | 1 |
| Chapman, V; Kelly, S | 2 |
| Itoh, H; Kawabata, A; Kawao, N; Kuroda, R; Shimada, C | 1 |
| Arden, WA; Chung, E; Gu, Q; Kwong, K; Lee, LY | 1 |
| Adner, M; Andersson, DA; Högestätt, ED; Zygmunt, PM | 1 |
| Kollarik, M; Undem, BJ | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, A; Russo, A; Sautebin, L | 1 |
| Andresen, MC; Bailey, TW; Doyle, MW; Jin, YH | 1 |
| Colley, S; Davis, C; Kotsonis, P; McIntyre, P; Phillips, E; Ranasinghe, S; Rang, H; Savidge, J; Shah, K; Winter, J | 1 |
| Ishida, Y; Nishigaki, M; Shibata, Y; Shimada, S; Ueda, T; Ugawa, S | 1 |
| Ahluwalia, J; Nagy, I; Rang, H | 1 |
| Christie, MJ; Connor, M; Dedov, VN; Duke, CC; Mandadi, S; Roufogalis, BD; Tran, VH | 1 |
| Egan, RW; Hey, JA; Jia, Y; McLeod, RL; Parra, LE; Wang, X | 1 |
| Atweh, SF; Jabbur, SJ; Massaad, CA; Ochoa-Chaar, CI; Saadé, NE; Safieh-Garabedian, B | 1 |
| Choi, JK; Choi, Jy; Choi, Sh; Jeong, YS; Jew, Ss; Kim, HD; Lee, J; Oh, U; Park, Hg; Park, Mk; Park, YH; Suh, Yg | 1 |
| Fox, AJ; McIntyre, P; Medhurst, SJ; Panesar, M; Patel, S; Urban, L; Walker, KM | 1 |
| Gharibova, LS; Li, T; Nicol, GD; Pei, Y; Southall, MD; Travers, JB | 1 |
| Helyes, Z; Jakab, B; Németh, J; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| Adinolfi, B; Breschi, MC; Calderone, V; Martinotti, E; Nieri, P; Testai, L | 1 |
| Christie, MJ; Jennings, EA; Roberts, LA; Vaughan, CW | 1 |
| Chiang, HT; Lo, YK; Wu, SN | 1 |
| Kaminski, NE; Li, J; Wang, DH | 1 |
| Agopyan, N; Li, L; Simon, SA; Yu, S | 1 |
| de la Fuente, SG; Fujino, K; Kihara, N; Mantyh, CR; Pappas, TN; Takahashi, T | 1 |
| Li, GD; Zhao, ZQ; Zhou, Y | 1 |
| Choi, H; Choi, JK; Jeong, YS; Kim, HD; Lee, HJ; Oh, U; Park, HG; Park, YH; Ryu, CH; Suh, YG; Yoon, J | 1 |
| Cury, Y; Zanchet, EM | 1 |
| Capasso, R; Mascolo, N | 1 |
| Bernardi, G; Berretta, N; Di Marzo, V; Maccarrone, M; Marinelli, S; Matias, I; Mercuri, NB | 1 |
| Matsumura, T; Moriyama, T; Sakurada, C; Sakurada, S; Sakurada, T; Ueno, S | 1 |
| Hirota, K; Lambert, DG; Smart, D | 1 |
| Deng, HW; Hu, CP; Li, NS; Li, YJ; Xiao, L | 1 |
| Bowles, WR; Hargreaves, KM; Jackson, DL | 1 |
| Gover, TD; Kao, JP; Weinreich, D | 1 |
| Galoyan, SM; Mendell, LM; Petruska, JC | 1 |
| Fischer, MJ; Reeh, PW; Sauer, SK | 1 |
| Dux, M; Jancsó, G; Sántha, P | 1 |
| Aihara, E; Kato, S; Kohama, K; Matsui, H; Nakamura, A; Takeuchi, K; Xin, H | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Adler-Graschinsky, E; Celuch, SM; del Carmen García, M | 1 |
| Kim, JS; Kim, YB; Lee, CH; Lee, JK; Oh, SB; Park, K; Piao, ZG; Yang, BH | 1 |
| Chen, CW; Fu, WM; Ho, FM; Lee, ST; Lin, WW; Wu, WT | 1 |
| Chen, ZH; Ding, ZH; Liu, JK; Liu, YD; Qing, C; Shen, ZQ; Yang, WM | 1 |
| Akerman, S; Goadsby, PJ; Kaube, H | 1 |
| Aoi, M; Kagawa, S; Kotani, T; Kubo, Y; Takeuchi, K | 1 |
| Lao, LJ; Marvizón, JC; Song, B | 1 |
| Cassar, SC; Esbenshade, T; Hancock, AA; Masters, JN; Witte, DG | 1 |
| Benham, CD; Davies, CH; Davis, JB; Gill, CH; Gitterman, DP; Harries, M; Lanneau, C; Ray, AM; Roberts, JC | 1 |
| Avelino, A; Charrua, A; Cruz, F; Matesz, K; Nagy, I; Santha, P; Sathianathan, V | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| Farquhar-Smith, WP; Rice, AS | 1 |
| Davies, CH; Davis, JB; Egerton, J; Gill, CH; Gunthorpe, MJ; Howett, L; Jerman, JC; Lappin, SC; Luis Hannan, S; Nasir, S; Owen, D; Rami, HK; Randall, AD; Smart, D; Smith, GD; Soffin, EM; Thompson, M; Worby, A; Wyman, PA | 1 |
| Blumberg, PM; Chen, Z; Kozikowski, AP; Tóth, A | 1 |
| Geracioti, TD; Kasckow, JW; Mulchahey, JJ | 1 |
| Harada, N; Isobe, H; Okajima, K; Uchiba, M | 3 |
| Bevan, S; McIntyre, P; Phillips, E; Reeve, A | 1 |
| Akopian, AN; Flores, CM; Hargreaves, KM; Patwardhan, A; Price, TJ | 1 |
| Evans, RM; Ross, RA; Scott, RH | 1 |
| Moon, C | 1 |
| Kyle, DJ; Tafesse, L | 1 |
| Fujimoto, S; Mori, M | 1 |
| Borrelli, F; Capasso, R; Izzo, AA; Pinto, A | 1 |
| de Lago, E; de Miguel, R; Fernández-Ruiz, J; Lastres-Becker, I; Ramos, JA | 1 |
| Ando, R; Kawamura, S; Watanabe, C; Yonezawa, A | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Kim, BM; Lee, SH; Oh, U; Shim, WS | 1 |
| Andresen, MC; Bailey, TW; Jin, YH; Li, BY; Schild, JH | 1 |
| Izydorczyk, I; Pethö, G; Reeh, PW | 1 |
| Godlewski, G; Malinowska, B; Schlicker, E | 1 |
| Adler-Graschinsky, E; Becu-Villalobos, D; Celuch, SM; Huidobro-Toro, JP; Orliac, ML; Peroni, RN | 1 |
| Chapman, V; Kendall, DA; Millns, PJ; Sagar, DR; Smart, D; Smith, PA | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Fujita, T; Kawasaki, Y; Kumamoto, E; Yue, HY | 1 |
| Liu, M; Michael, GJ; Priestley, JV; Willmott, NJ | 1 |
| Jenkins, DW; Langmead, CJ; Parsons, AA; Strijbos, PJ | 1 |
| Bizik, F; Blumberg, PM; Kedei, N; Kozikowski, AP; Pearce, LV; Petukhov, PA; Szabo, T | 1 |
| Nagao, M; Shimada, S; Ueda, T; Ugawa, S; Yamamura, H | 2 |
| Colleoni, M; Costa, B; Franke, C; Giagnoni, G; Trovato, AE | 1 |
| Bates, SA; Benham, CD; Cairns, W; Davies, CH; Gill, CH; Hill, K; Larkman, PM; Murdock, PR; Owen, D; Powell, AJ; Randall, A; Strijbos, PJ; Yusaf, SP | 1 |
| Advenier, C; Chinet, T; Fagon, JY; Faisy, C; Guerot, E; Naline, E; Risse, PA; Roche, N; Rouget, C | 1 |
| Akiba, Y; Hibi, T; Ishii, H; Kato, S; Katsube, K; Nakamura, M; Takeuchi, K | 1 |
| Chang, HT; Chen, JS; Cheng, HH; Cheng, JS; Hsu, SS; Huang, CJ; Huang, JK; Jan, CR; Jiann, BP; Lo, YK; Teng, HP; Yeh, JH | 1 |
| Han, IS; Kang, JH; Kawada, T; Kim, CS; Kim, MO; Park, JY; Park, WH; Yoo, H; Yu, R | 1 |
| Amantini, C; Lucciarini, R; Morrone, S; Mosca, M; Perfumi, M; Piccoli, M; Santoni, G | 1 |
| Dogan, MD; Patel, S; Romanovsky, AA; Rudaya, AY; Steiner, AA; Székely, M | 1 |
| Ahluwalia, A; Chauhan, S; Davis, C; De Felipe, C; Hunt, S; Kabir, J; Kotsonis, P; Oh, U; Scotland, RS | 1 |
| de la Fuente, SG; Fujino, K; Ludwig, KA; Mantyh, CR; Takami, Y | 1 |
| Bembry, J; Chen, Y; Golech, SA; Lenz, F; McCarron, RM; Mechoulam, R; Shohami, E; Spatz, M | 1 |
| Barritt, GJ; Zhang, L | 1 |
| Kadowaki, M; Kuramoto, H; Takaki, M | 1 |
| Cloutier, M; Morin, C; Proteau, S; Rousseau, E | 1 |
| Sun, Q; Valenzano, KJ | 1 |
| Deng, PY; Hu, CP; Li, YJ; Tan, GS; Xu, KP; Yu, J | 1 |
| D'Andrea, MR; Hornby, PJ; Kimball, ES; Schneider, CR; Wallace, NH | 1 |
| Avelino, A; Bevan, S; Charrua, A; Cruz, F; Dinis, P; Nagy, I; Yaqoob, M | 1 |
| Deng, HW; Du, YH; Hu, CP; Li, YJ; Peng, J; Rang, WQ; Xu, KP; Ye, F | 1 |
| Henderson, D; Liu, L; Lu, G; Reinhart, PH; Simon, SA | 1 |
| Gu, Q; Hu, HZ; Lee, LY; Lin, RL; Zhu, MX | 1 |
| Ajioka, H; Horie, S; Kunieda, K; Murayama, T; Someya, A | 1 |
| Bulmer, DC; Davis, JB; Grundy, D; Hicks, GA; Jiang, W; Winchester, WJ | 1 |
| Braida, D; Consalez, GG; Croci, L; Guerini-Rocco, C; Pegorini, S; Sala, M; Verzoni, C | 1 |
| Bianchi, R; Borsani, E; Buffoli, B; Rezzani, R; Ricci, F; Rodella, LF | 1 |
| Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C | 1 |
| Gunthorpe, MJ; McNamara, FN; Randall, A | 1 |
| Lam, PM; Lambert, DG; McDonald, J | 1 |
| Bunnett, NW; Day, AL; Grady, EF; Hutter, MM; Jordan, TH; Kirkwood, KS; Maa, J; Mulvihill, SJ; Richmond, AC; Wick, EC; Zerega, EC | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Bielefeldt, K; Dang, K; Gebhart, GF | 1 |
| Cadet, JL; Chen, J; Deng, X; Errico, S; Freed, WJ; Lee, CT | 1 |
| Kohama, K; Nakamura, A; Takemori, S; Tanaka, H; Xin, H; Yamaguchi, M | 1 |
| Breuer, A; Fride, E; Hanus, L; Ponde, D | 1 |
| Maor, Y; Mechoulam, R; Pertwee, RG; Stevenson, LA; Thomas, A | 1 |
| DeSimone, JA; Heck, GL; Lyall, V; Malik, SA; Mummalaneni, S; Phan, TH; Vinnikova, AK | 2 |
| Hognestad, H; Hucho, F; Illes, P; Jahnel, R; Wirkner, K | 1 |
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| González-Anduaga, GM; López-Ortíz, M; Navarrete, A; Palomino-Hernández, O; Quiñonez-Bastidas, GN; Regla, I; Rocha-González, HI | 1 |
| Abdulla, MH; AlMarabeh, S; Cavers, J; Lucking, EF; O'Halloran, KD; O'Neill, J | 1 |
| Hong, JI; Hwang, HS; Kim, HA; Kim, JR; Park, IY | 1 |
| Christie, S; Zagorodnyuk, V | 1 |
| Hara, K; Haranishi, Y; Terada, T | 1 |
| Baudouin, C; Fakih, D; Guerrero-Moreno, A; Parsadaniantz, SM; Réaux-Le Goazigo, A | 1 |
| Arenas, AP; Castrejón-Téllez, V; Del Valle-Mondragón, L; Guarner-Lans, V; Pastelín-Hernández, G; Pérez-Torres, I; Rojas, FM; Torres-Narváez, JC; Varela-López, E; Vargas-González, A | 1 |
| Bäumer, W; Kietzmann, M; Mishra, SK; Rossbach, K; Stark, H; Wilzopolski, J | 1 |
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Mizogami, M; Tsuchiya, H | 1 |
| Bishnoi, M; Chopra, K; Devi, K; Khan, R; Kondepudi, KK; Kumar, A; Kumar, V; Rajarammohan, S; Singh, RP | 1 |
| Abdolmaleki, Z; Shahidi, S; Zarei, MM | 1 |
| Benzing, T; Brinkkoetter, PT; Chen, H; Dryer, S; Hagmann, H; Khayyat, NH; Matin, M; Oezel, C; Schauss, A; Schell, C | 1 |
| Çakır, M; Çiğremiş, Y; Durhan, M; Kaymak, E; Mustafa Özkut, M; Tekin, S; Yüksel, F | 1 |
| Chhatwal, S; Li, A; Lucius, A; Mergler, S; Pleyer, U; Reinach, PS; Valtink, M | 1 |
7 review(s) available for capsaicin and capsazepine
| Article | Year |
|---|---|
Mechanism of action of capsaicin-like molecules on sensory neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channels; Capsaicin; Cell Membrane; Humans; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Receptors, Drug | 1992 |
Neuropharmacological mechanisms of capsaicin and related substances.
Topics: Animals; Capsaicin; Humans; Ion Channels; Nervous System; Neuropeptides; Receptors, Drug | 1992 |
Capsaicin: gaps in our knowledge start to be filled.
Topics: Animals; Axonal Transport; Capsaicin; Nerve Degeneration; Nerve Endings; Nerve Fibers; Nerve Growth Factors; Neurons, Afferent; Pain; Receptors, Drug; Sciatic Nerve; Silver Nitrate; Spinal Cord; Staining and Labeling | 1991 |
Current perspectives on the therapeutic utility of VR1 antagonists.
Topics: Animals; Capsaicin; Humans; Receptors, Drug | 2004 |
Sepsis: The Involvement of Platelets and the Current Treatments.
Topics: Acetylcysteine; Animals; Blood Platelets; Capsaicin; Chloroquine; Disseminated Intravascular Coagulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-7; Platelet Aggregation Inhibitors; Sepsis; Software; Thrombocytopenia; Toll-Like Receptor 4 | 2018 |
Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Capsaicin; Cell Line, Tumor; Humans; Janus Kinases; NF-kappa B; Reactive Oxygen Species; Signal Transduction; TRPV Cation Channels | 2019 |
The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Endocannabinoids; Humans; Parkinson Disease; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2020 |
2 trial(s) available for capsaicin and capsazepine
| Article | Year |
|---|---|
Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans.
Topics: Adult; Capsaicin; Enzyme Inhibitors; Female; Hot Temperature; Humans; Hyperemia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Temperature; TRPV Cation Channels | 2010 |
Transient receptor potential vanilloid type 1 channels contribute to reflex cutaneous vasodilation in humans.
Topics: Adult; Blood Pressure; Body Temperature; Capsaicin; Female; Forearm; Heating; Humans; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Reflex; Regional Blood Flow; Skin; TRPV Cation Channels; Vasodilation; Young Adult | 2012 |
712 other study(ies) available for capsaicin and capsazepine
| Article | Year |
|---|---|
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Crystallography, X-Ray; Diterpenes; Ganglia, Spinal; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neurons, Afferent; Neurotoxins; Rats; Receptors, Drug; Structure-Activity Relationship | 1994 |
Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity.
Topics: Animals; Body Temperature; Diterpenes; Edema; Homovanillic Acid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Proteins; Molecular Structure; Phorbol Esters; Protein Binding; Rats; Receptors, Drug; Spinal Cord | 1996 |
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Ligands; Male; Mice; Mice, Inbred ICR; Rats; Receptors, Drug; Structure-Activity Relationship; Sulfonamides; Thiourea | 2003 |
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.
Topics: Animals; Animals, Newborn; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Ligands; Molecular Structure; Neurons; Rats; Receptors, Drug; Structure-Activity Relationship; Sulfonamides; Thiourea | 2004 |
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Topics: Administration, Oral; Aminopyridines; Analgesics; Animals; Biological Availability; Body Temperature; Calcium; Capsaicin; Cell Line; Humans; Hypothermia; Ion Channels; Male; Pain Measurement; Piperazines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2005 |
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
Topics: Animals; Binding, Competitive; Calcium Signaling; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Humans; Isoquinolines; Ligands; Molecular Structure; Neurons, Afferent; Radioligand Assay; Rats; Recombinant Proteins; Stereoisomerism; Transfection; Tritium; TRPV Cation Channels; Urea | 2007 |
In vitro TRPV1 activity of piperine derived amides.
Topics: Alkaloids; Amides; Benzodioxoles; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Spectrometry, Fluorescence; TRPV Cation Channels | 2010 |
Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.
Topics: Africa; Alkaloids; Calcium; Capsaicin; Humans; Ibogaine; Menthol; Molecular Structure; Plant Bark; Pyrimidinones; Transient Receptor Potential Channels; Trees; TRPV Cation Channels; Voacanga | 2014 |
Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Citrates; Citric Acid; Electric Stimulation; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Neurokinin A; Neurons, Afferent; Nicotine; Receptors, Drug; Respiratory Physiological Phenomena; Respiratory System; Ruthenium Red; Tidal Volume; Vagus Nerve | 1992 |
Inhibitory effects of capsazepine and the NK2 antagonist SR 48968 on bronchoconstriction evoked by sensory nerve stimulation in guinea-pigs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Electric Stimulation; Female; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1992 |
Capsazepine as a selective antagonist of capsaicin-induced activation of C-fibres in guinea-pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Nerve Fibers; Ruthenium Red; Tetrodotoxin | 1992 |
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; Freund's Adjuvant; Hyperalgesia; Irritants; Mice; Morphine; Naloxone; Pain Measurement; Rats; Rats, Wistar; Uric Acid | 1992 |
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin.
Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Electrophysiology; gamma-Aminobutyric Acid; Ganglia, Spinal; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Vagus Nerve | 1992 |
Capsazepine inhibits low pH- and lactic acid-evoked release of calcitonin gene-related peptide from sensory nerves in guinea-pig heart.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Lactates; Lactic Acid; Nerve Fibers | 1992 |
Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Electric Stimulation; Ganglia, Spinal; Mice; Receptors, Drug; Spinal Cord; Substance P | 1991 |
Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Electric Stimulation; In Vitro Techniques; Injections, Spinal; Nerve Fibers; Rats; Receptors, Drug; Spinal Cord; Spinal Nerve Roots | 1991 |
Effects of ruthenium red and capsazepine on C-fibres in the rabbit iris.
Topics: Animals; Bradykinin; Capsaicin; Drug Interactions; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neuromuscular Junction; Rabbits; Ruthenium Red | 1993 |
Evidence that glutamate is released from capsaicin-sensitive primary afferent fibers in rats: study with on-line continuous monitoring of glutamate.
Topics: Animals; Calcium; Capsaicin; Enzymes, Immobilized; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1994 |
Resiniferatoxin binding to vanilloid receptors in guinea pig and human airways.
Topics: Adult; Animals; Binding Sites; Bronchi; Capsaicin; Diterpenes; Female; Guinea Pigs; Humans; Male; Middle Aged; Neurotoxins; Receptors, Drug; Trachea; Tritium | 1995 |
Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig.
Topics: Afferent Pathways; Animals; Capsaicin; Electrophysiology; Evoked Potentials; Female; Guinea Pigs; Hydrogen-Ion Concentration; Male; Nerve Fibers; Protons; Trachea; Vagus Nerve | 1995 |
Ruthenium red, but not capsazepine reduces plasma extravasation by cigarette smoke in rat airways.
Topics: Aerosols; Animals; Capillary Permeability; Capsaicin; Evans Blue; Nerve Fibers; Rats; Rats, Inbred F344; Ruthenium Red; Smoking | 1993 |
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Rats; Rats, Wistar; Ruthenium Red; Urinary Bladder; Vas Deferens | 1993 |
The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons.
Topics: Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Drug Tolerance; Ethers, Cyclic; Extracellular Space; Ganglia, Spinal; Inositol Phosphates; Ion Channels; Ionomycin; Mitochondria; Neurons, Afferent; Okadaic Acid; Potassium Chloride; Rats; Rats, Sprague-Dawley; Signal Transduction | 1993 |
Characterization by [3H]resiniferatoxin binding of a human vanilloid (capsaicin) receptor in post-mortem spinal cord.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Membranes; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Drug; Spinal Cord | 1994 |
[3H]resiniferatoxin binding by the human vanilloid (capsaicin) receptor.
Topics: Animals; Binding, Competitive; Capsaicin; Diterpenes; Female; Humans; Kinetics; Medulla Oblongata; Nerve Tissue Proteins; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Species Specificity; Spinal Cord; Trigeminal Nuclei | 1994 |
Capsazepine abolishes pulmonary chemoreflexes induced by capsaicin in anesthetized rats.
Topics: Anesthesia; Animals; Biguanides; Capsaicin; Chemoreceptor Cells; Female; Lung; Male; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Respiration | 1994 |
Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat.
Topics: Animals; Axons; Binding Sites; Binding, Competitive; Capsaicin; Diterpenes; Female; Ganglia, Spinal; Kinetics; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Cord; Substrate Specificity; Tritium; Urinary Bladder; Vagus Nerve | 1994 |
Detection of capsaicin-evoked release of glutamate from spinal dorsal horn slices of rat with on-line monitoring system.
Topics: Animals; Biosensing Techniques; Capsaicin; Enzymes, Immobilized; Fluorometry; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Male; Monitoring, Physiologic; Nerve Endings; Neurons, Afferent; Online Systems; Perfusion; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1993 |
Cyclo-oxygenase products released by low pH have capsaicin-like actions on sensory nerves in the isolated guinea pig heart.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Diclofenac; Epoprostenol; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Indomethacin; Lactates; Lactic Acid; Neurons, Afferent; Perfusion; Receptors, Drug | 1994 |
Involvement of tachykinin and CGRP receptors in the cardio-pulmonary effects evoked by capsaicin in the guinea-pig.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Blood Proteins; Bronchoconstriction; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Glycopeptides; Guinea Pigs; Heart Rate; Male; Metalloendopeptidases; Receptors, Calcitonin Gene-Related Peptide; Receptors, Tachykinin | 1993 |
Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH, capsaicin and potassium in rat soleus muscle.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscles; Neurons, Afferent; Potassium; Rats; Rats, Wistar | 1993 |
Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat.
Topics: Animals; Binding Sites; Binding, Competitive; Bronchi; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Membranes; Neurons; Rats; Receptors, Drug; Sensitivity and Specificity; Spinal Cord; Trachea; Tritium; Urinary Bladder | 1993 |
Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat.
Topics: Administration, Topical; Animals; Capsaicin; Colitis; Diterpenes; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trinitrobenzenesulfonic Acid | 1993 |
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea.
Topics: Animals; Capsaicin; Diterpenes; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins; Trachea | 1994 |
Capsaicin-induced activation of fine afferent fibres from rat skin in vitro.
Topics: Afferent Pathways; Animals; Capsaicin; Cold Temperature; Dose-Response Relationship, Drug; Electric Stimulation; Hot Temperature; In Vitro Techniques; Mechanoreceptors; Nerve Fibers; Rats; Rats, Sprague-Dawley; Skin | 1993 |
Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Female; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; Male; Neurokinin A; Neurons, Afferent; Piperidines | 1993 |
Capsazepine-sensitive release of calcitonin gene-related peptide from C-fibre afferents in the guinea-pig heart by low pH and lactic acid.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; Heart; Heart Rate; Hydrogen-Ion Concentration; In Vitro Techniques; Lactates; Lactic Acid; Nerve Fibers; Neurons, Afferent; Nicotine | 1993 |
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs.
Topics: Animals; Antitussive Agents; Bronchodilator Agents; Capsaicin; Citrates; Citric Acid; Cough; Guinea Pigs; Irritants; Male; Protons; Saline Solution, Hypertonic; Terbutaline | 1995 |
Capsaicin-induced biphasic oxygen uptake in rat muscle: antagonism by capsazepine and ruthenium red provides further evidence for peripheral vanilloid receptor subtypes (VN1/VN2).
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Hindlimb; Male; Muscles; Oxygen; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red | 1996 |
Pharmacological characterization of the vanilloid receptor in the rat isolated vas deferens.
Topics: Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Antagonism; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Receptors, Drug; Vas Deferens | 1996 |
Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons.
Topics: Acids; Animals; Animals, Newborn; Capsaicin; Cations; Cells, Cultured; Diterpenes; Ganglia, Spinal; Ion Channels; Models, Neurological; Neurons; Neurotoxins; Rats | 1996 |
Autoradiographic visualization and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Bronchi; Capsaicin; Cricetinae; Diterpenes; Female; Guinea Pigs; Humans; Male; Mesocricetus; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Swine | 1995 |
Pharmacology of calcitonin gene related peptide release from sensory terminals in the rat trachea.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Indomethacin; Male; Nerve Fibers; Oxidopamine; Prostaglandins; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Trachea | 1995 |
Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn.
Topics: Adult; Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Binding, Competitive; Capsaicin; Carbazoles; Diterpenes; Female; Humans; In Vitro Techniques; Membranes; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Trifluoperazine | 1996 |
Effect of capsaicin and analogues on potassium and calcium currents and vanilloid receptors in Xenopus embryo spinal neurones.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capsaicin; Embryo, Nonmammalian; Membrane Potentials; Neurons; Potassium Channel Blockers; Potassium Channels; Receptors, Drug; Spinal Cord; Time Factors; Xenopus | 1996 |
Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi.
Topics: Adult; Benzamides; Bronchi; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Female; Humans; Male; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Piperidines; Tachykinins | 1997 |
Capsaicin and carbon dioxide act by distinct mechanisms on sensory nerve terminals in the cat cornea.
Topics: Animals; Capsaicin; Carbon Dioxide; Cats; Cornea; Drug Interactions; Electrophysiology; Female; Male; Nerve Endings; Neurons, Afferent | 1997 |
The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Capsaicin; Eugenol; Guaiacol; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain Threshold; Receptors, Drug; Structure-Activity Relationship | 1997 |
The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Glycerol; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tachyphylaxis; Taste; Trigeminal Ganglion | 1997 |
Activation of chemosensitive neurons in the ventrolateral medulla by capsaicin in cats.
Topics: Analysis of Variance; Animals; Autonomic Fibers, Preganglionic; Blood Pressure; Capsaicin; Cats; Drug Evaluation, Preclinical; Heart Rate; Medulla Oblongata; Neurons; Ruthenium Red; Sympathetic Nervous System | 1997 |
Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia.
Topics: Animals; Capsaicin; Electric Conductivity; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion | 1997 |
Antinociception induced by civamide, an orally active capsaicin analogue.
Topics: Administration, Oral; Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Hot Temperature; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1997 |
Enhancement of rat trigeminal ganglion neuron responses to piperine in a low-pH environment and block by capsazepine.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Binding, Competitive; Capsaicin; Female; Hydrogen-Ion Concentration; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Protons; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 1997 |
Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Male; omega-Conotoxin GVIA; Peptides; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
Eugenol activates Ca(2+)-permeable currents in rat dorsal root ganglion cells.
Topics: Animals; Animals, Newborn; Calcium Channel Agonists; Calcium Channels; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Eugenol; Female; Ganglia, Spinal; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Drug | 1997 |
Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intradermal; Injections, Intraventricular; Male; Mice; Naloxone; Pain; Ruthenium Red | 1997 |
Peripheral CGRP release as a marker for neurogenic inflammation: a model system for the study of neuropeptide secretion in rat paw skin.
Topics: Animals; Basal Metabolism; Biomarkers; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hindlimb; Male; Nerve Endings; Neuritis; Neuropeptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin | 1997 |
Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.
Topics: Animals; Animals, Newborn; Bradykinin; Capsaicin; Cells, Cultured; Coculture Techniques; Dinoprostone; Drug Synergism; Ganglia, Spinal; Hippocampus; Hydrogen-Ion Concentration; Inflammation; Ion Channel Gating; Neuroglia; Neurons, Afferent; Rats; Receptors, Drug; Serotonin; Stimulation, Chemical | 1998 |
Identification of the L-menthol binding site in guinea-pig lung membranes.
Topics: Animals; Benzazepines; Binding Sites; Camphor; Capsaicin; Cell Membrane; Eugenol; Guinea Pigs; In Vitro Techniques; Lung; Male; Menthol; Radioligand Assay; Tritium | 1998 |
A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Diterpenes; Kinetics; Membrane Potentials; Neurons, Afferent; Neurotoxins; Patch-Clamp Techniques; Phorbol Esters; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Trigeminal Ganglion | 1998 |
Specific vanilloid responses in C6 rat glioma cells.
Topics: Animals; Calcium Radioisotopes; Capsaicin; Cell Differentiation; Cell Division; Diterpenes; Glioma; Neurotoxins; Rats; Receptors, Drug; Tumor Cells, Cultured | 1998 |
Capsaicin treatment induces muscarinic hyperreactivity in guinea pig trachea: a warning.
Topics: Animals; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Receptors, Muscarinic; Receptors, Tachykinin; Trachea | 1998 |
The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies.
Topics: Animals; Capsaicin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Electric Conductivity; Ion Channel Gating; Ion Channels; Neurons, Afferent; Osmolar Concentration; Rats; Rats, Sprague-Dawley | 1998 |
Capsaicin receptors mediate free radical-induced activation of cardiac afferent endings.
Topics: Adrenergic Fibers; Animals; Bradykinin; Capsaicin; Coloring Agents; Free Radicals; Heart; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Drug; Ruthenium Red; Sensory Receptor Cells; Stellate Ganglion; Vagus Nerve; Xanthine; Xanthine Oxidase | 1998 |
Mechanism of acid-induced mesenteric hyperemia in rats.
Topics: Animals; Blood Pressure; Capsaicin; Duodenum; Hydrochloric Acid; Hyperemia; Laser-Doppler Flowmetry; Male; Mesenteric Arteries; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Ruthenium Red | 1998 |
Capsaicin-induced desensitization is prevented by capsazepine but not by ruthenium red in guinea pig bronchi.
Topics: Animals; Bronchi; Calcium; Capsaicin; Coloring Agents; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxation; Ruthenium Red | 1998 |
A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance.
Topics: Animals; Capsaicin; Carrageenan; Functional Laterality; Hindlimb; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Spinal Cord | 1998 |
Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus.
Topics: Animals; Bronchi; Bronchoconstriction; Capsaicin; Cyclosporine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunosuppressive Agents; In Vitro Techniques; Muscle, Smooth; Neurons, Afferent; Neuropeptides; Receptors, Cholinergic; Tacrolimus | 1998 |
Anandamide transport inhibition by the vanilloid agonist olvanil.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Astrocytoma; Biological Transport; Brain; Capsaicin; Depression, Chemical; Endocannabinoids; Humans; Polyunsaturated Alkamides; Rats; Receptors, Drug; Tumor Cells, Cultured | 1999 |
Inhibition by a capsaicin antagonist (capsazepine) of capsaicin-induced swimming capacity increase in mice.
Topics: Animals; Capsaicin; Chromatography, High Pressure Liquid; Epinephrine; Male; Mice; Physical Exertion; Receptors, Drug; Swimming | 1998 |
Mechanisms of capsaicin- and lactic acid-induced bronchoconstriction in the newborn dog.
Topics: Animals; Animals, Newborn; Bronchi; Bronchoconstriction; Capsaicin; Dogs; Lactic Acid; Lung; Lung Compliance; Nerve Fibers; Receptors, Drug; Reflex | 1999 |
Modulation by nitric oxide (NO) of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons.
Topics: Animals; Calcium; Capsaicin; Dithionitrobenzoic Acid; Dithiothreitol; Ganglia, Spinal; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Spermine; Verapamil | 1999 |
Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Male; Substance P | 1999 |
A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors.
Topics: Animals; Basidiomycota; Binding, Competitive; Calcium; Calcium Radioisotopes; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Eye; Female; Ganglia, Spinal; Humans; Irritants; Male; Membrane Potentials; Membranes; Neurons; Patch-Clamp Techniques; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Taste; Tongue; Tritium | 1999 |
Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices.
Topics: Animals; Capsaicin; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission | 1999 |
Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors.
Topics: Anesthesia; Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Tidal Volume | 1999 |
Rat peripheral nerve components release calcitonin gene-related peptide and prostaglandin E2 in response to noxious stimuli: evidence that nervi nervorum are nociceptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dinoprostone; Electric Stimulation; Inflammation Mediators; Male; Nociceptors; Pain; Peripheral Nerves; Rats; Rats, Wistar; Ruthenium Red; Stimulation, Chemical | 1999 |
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.
Topics: Animals; Arachidonic Acids; Basilar Artery; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium Channels; Capsaicin; Cell Line; Endocannabinoids; Female; Guinea Pigs; Hepatic Artery; In Vitro Techniques; Neurons, Afferent; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Vasodilator Agents; Xenopus | 1999 |
Acid-sensing pathways of rat duodenum.
Topics: Acids; Animals; Bradykinin; Capsaicin; Chemoreceptor Cells; Duodenum; Hyperemia; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Regional Blood Flow; Time Factors | 1999 |
The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons.
Topics: Animals; Biological Transport; Calcium; Calcium-Binding Proteins; Capsaicin; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Diterpenes; Ganglia, Spinal; Humans; Neurons; Nociceptors; Rats; Receptors, Drug; Transfection; Tritium; TRPV Cation Channels; Vanillic Acid | 1999 |
Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin.
Topics: Animals; Calcium; Capsaicin; Cell Survival; Cells, Cultured; Electrophysiology; Hot Temperature; Ion Channels; Neurons, Afferent; Rats; Ruthenium Red | 1999 |
Inhibition of rapid heat responses in nociceptive primary sensory neurons of rats by vanilloid receptor antagonists.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Female; Ganglia, Spinal; Hot Temperature; Male; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; Signal Transduction; Solutions | 1999 |
Inhibitory effect of capsaicin on cholinergic transmission in ovine airways: evidence for non-cholinergic contractions.
Topics: Acetylcholine; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptides, Cyclic; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-2; Serotonin; Sheep; Substance P; Synaptic Transmission; Trachea | 1999 |
Stimulation of dichlorofluorescin oxidation by capsaicin and analogues in RAW 264 monocyte/macrophages: lack of involvement of the vanilloid receptor.
Topics: Acetylcysteine; Animals; Antioxidants; Capsaicin; Carcinogens; Chromans; Fluoresceins; Macrophages; Mice; Monocytes; Oxidation-Reduction; Polysorbates; Reactive Oxygen Species; Receptors, Drug; Surface-Active Agents; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vitamin K | 2000 |
Modulation of capsaicin-sensitive nerve activation by low pH solutions in guinea-pig lung.
Topics: Animals; Bronchoconstriction; Buffers; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Female; Guinea Pigs; Hydrogen-Ion Concentration; Lactic Acid; Lung; Male; Neurons, Afferent | 2000 |
Anandamide: an endogenous activator of the vanilloid receptor.
Topics: Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Endocannabinoids; Humans; Ligands; Polyunsaturated Alkamides; Receptors, Drug | 2000 |
Interactions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptors.
Topics: Animals; Bradykinin; Capsaicin; Dinoprostone; Drug Interactions; Ganglia, Spinal; Hydrogen-Ion Concentration; Inflammation; Inflammation Mediators; Male; Nerve Fibers; Nociceptors; Oxytocics; Protons; Rats; Rats, Wistar; Serotonin; Signal Transduction; Skin | 2000 |
Cytotoxicity of capsaicin in monkey kidney cells: lack of antagonistic effects of capsazepine and Ruthenium red.
Topics: Animals; Calcium; Capsaicin; Chlorocebus aethiops; Chromatography, High Pressure Liquid; DNA; Kidney; Mitochondria; Protein Synthesis Inhibitors; Receptors, Drug; Ruthenium Red; Spectrometry, Fluorescence; TRPV Cation Channels; Tyrosine; Vero Cells | 2000 |
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances.
Topics: Animals; Capsaicin; Cell Line; Cells, Cultured; Dinoprostone; Eicosanoids; Ganglia, Spinal; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Ion Channel Gating; Leukotriene B4; Leukotrienes; Ligands; Lipid Peroxides; Lipoxygenase; Molecular Structure; Neurons, Afferent; Prostaglandin D2; Prostaglandin H2; Prostaglandins H; Rats; Receptors, Drug; Structure-Activity Relationship | 2000 |
Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1).
Topics: Action Potentials; Animals; Barium; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Humans; Ion Channel Gating; Kidney; Kinetics; Magnesium; Neurons; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Inbred Strains; Receptors, Drug; Recombinant Proteins; Time Factors; Transfection | 2000 |
Inflammatory mediators release calcitonin gene-related peptide from dorsal root ganglion neurons of the rat.
Topics: Acids; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Dinoprostone; Female; Free Radical Scavengers; Ganglia, Spinal; Hydrogen-Ion Concentration; Inflammation Mediators; Kallidin; Male; Neurons; Rats; Rats, Wistar; Receptors, Drug; Serotonin; Stimulation, Chemical | 2000 |
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.
Topics: Animals; Calcium; Capsaicin; Cell Line; Diterpenes; DNA, Recombinant; Dose-Response Relationship, Drug; Fluorometry; Humans; Hydrogen-Ion Concentration; Ligands; Phorbol Esters; Polycyclic Sesquiterpenes; Rats; Receptors, Drug; Ruthenium Red; Sesquiterpenes; Transfection | 2000 |
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2 | 2000 |
Low-threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin-insensitive.
Topics: Animals; Capsaicin; Cell Size; Cells, Cultured; Chickens; Cobalt; Ganglia, Spinal; Hot Temperature; Ion Channels; Male; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Ruthenium Red; Thermosensing | 2000 |
Induction of apoptosis by capsaicin in A172 human glioblastoma cells.
Topics: Apoptosis; Brain Neoplasms; Calcium; Capsaicin; Dose-Response Relationship, Drug; Glioblastoma; Humans; Kinetics; Lipid Peroxidation; Reactive Oxygen Species; Receptors, Drug; Tumor Cells, Cultured | 2000 |
Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Hindlimb; Male; Oxygen Consumption; Perfusion; Phorbol Esters; Rats; Rats, Wistar; Vascular Resistance; Vasoconstriction | 2000 |
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Eye; Female; Ganglia, Spinal; Guinea Pigs; Hindlimb; Hyperalgesia; Irritants; Male; Mice; Mice, Inbred Strains; Nociceptors; Nose; Odorants; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Turpentine; Urea | 2000 |
Differential effects of capsaicin on rat visceral sensory neurons.
Topics: Action Potentials; Animals; Calcium; Capsaicin; Cells, Cultured; Intracellular Fluid; Male; Neurons, Afferent; Nociceptors; Nodose Ganglion; Potassium Channels; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium Channels; Tetrodotoxin; TRPV Cation Channels; Visceral Afferents | 2000 |
ACTH inhibits the capsaicin-evoked release of CGRP from rat adrenal afferent nerves.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; TRPV Cation Channels; Zona Glomerulosa | 2001 |
Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints.
Topics: Animals; Arachidonic Acids; Arthritis, Experimental; Calcium Channel Blockers; Capsaicin; Disease Models, Animal; Drug Interactions; Endocannabinoids; Knee Joint; Male; Nociceptors; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Drug; Treatment Outcome; TRPV Cation Channels | 2001 |
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Biological Transport; Calcium; Calcium Channel Blockers; Cannabinoids; Capsaicin; CHO Cells; Cricetinae; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Transfection; TRPV Cation Channels; Vas Deferens | 2001 |
Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Ganglia, Spinal; In Vitro Techniques; Male; Neurons, Afferent; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord; Substance P; TRPV Cation Channels | 2001 |
Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries.
Topics: Animals; Arachidonic Acids; Benzoxazines; Biological Factors; Calcium Channel Blockers; Cannabinoids; Capsaicin; Electrophysiology; Endocannabinoids; Endothelium, Vascular; Membrane Potentials; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant; Vasodilator Agents | 2001 |
Sensory pathways and cyclooxygenase regulate mucus gel thickness in rat duodenum.
Topics: Animals; Bradykinin; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Duodenum; Enzyme Inhibitors; Injections, Intravenous; Intestinal Mucosa; Mucus; Perfusion; Prostaglandin-Endoperoxide Synthases; Rats; Signal Transduction | 2001 |
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1).
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Sequence Data; Phorbol Esters; Rats; Receptors, Drug; Ruthenium Red; Species Specificity; Xenopus | 2001 |
Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1.
Topics: Animals; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Coloring Agents; Cricetinae; Female; Ganglia, Spinal; Hot Temperature; Intracellular Fluid; Membrane Potentials; Neurons; Ovary; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; TRPV Cation Channels | 2001 |
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
Topics: Alkaloids; Aniline Compounds; Arachidonic Acids; Benzophenanthridines; Calcium; Capsaicin; Cell Line; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Fluorescence; Fluorometry; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Phenanthridines; Polycyclic Sesquiterpenes; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Drug; Ruthenium Red; Sesquiterpenes; Time Factors; Xanthenes | 2001 |
Capsazepine, a vanilloid receptor antagonist, inhibits the expression of inducible nitric oxide synthase gene in lipopolysaccharide-stimulated RAW264.7 macrophages through the inactivation of nuclear transcription factor-kappa B.
Topics: Animals; Capsaicin; Cell Line; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Receptors, Drug; RNA, Messenger | 2001 |
Capsaicin-induced relaxation in rabbit coronary artery.
Topics: 4-Aminopyridine; Animals; Calcium; Capsaicin; Coronary Vessels; Dinoprost; Drug Interactions; Fluorescent Dyes; Fura-2; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Potassium Channel Blockers; Potassium Channels; Rabbits; Ruthenium Red | 2001 |
Genital grooming and emesis induced by vanilloids in Suncus murinus, the house musk shrew.
Topics: Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Male; Sexual Behavior, Animal; Shrews; Time Factors; Vomiting | 2001 |
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide.
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Endocannabinoids; Gene Expression; Humans; Polyunsaturated Alkamides; Rats; Receptors, Drug; Recombinant Proteins; Ruthenium Red; Temperature | 2001 |
Effects of capsaicin on Ca(2+) release from the intracellular Ca(2+) stores in the dorsal root ganglion cells of adult rats.
Topics: Animals; Bradykinin; Caffeine; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Cytophotometry; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Ganglia, Spinal; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Type C Phospholipases | 2001 |
Vanilloid receptor expression and capsaicin excitation of rat dental primary afferent neurons.
Topics: Animals; Capsaicin; Carbocyanines; Cells, Cultured; Dental Pulp; Electrophysiology; Fluorescent Dyes; Male; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trigeminal Ganglion | 2001 |
The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats.
Topics: Acute-Phase Reaction; Animals; Bacterial Toxins; Capsaicin; Clostridioides difficile; Dose-Response Relationship, Drug; Drug Interactions; Endocytosis; Enteritis; Enterotoxins; Ileum; Immunohistochemistry; Intestinal Secretions; Male; Neurogenic Inflammation; Neurons; Peroxidase; Rats; Receptors, Drug; Substance P; Time Factors | 2001 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Indomethacin; Lipoxygenase; Muscle Contraction; Oxazepines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Thiorphan | 2001 |
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, Intravenous; Binding Sites; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Nervous System; Pain; Patch-Clamp Techniques; Propofol; Receptors, Drug | 2001 |
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
Topics: Amidohydrolases; Arachidonic Acids; Binding, Competitive; Biological Transport; Calcium; Cannabidiol; Capsaicin; Cell Line; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endocannabinoids; Gene Expression; Humans; Hydrolysis; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation | 2001 |
Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.
Topics: Amylases; Animals; Capsaicin; Endocytosis; Male; Mice; Mice, Inbred C57BL; Pancreas; Pancreatitis; Peroxidase; Receptors, Drug; Receptors, Neurokinin-1; Severity of Illness Index; Substance P; TRPV Cation Channels | 2001 |
Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Barium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Receptors, Drug; Rimonabant; Sheep; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2001 |
Capsaicin-evoked CGRP release from rat buccal mucosa: development of a model system for studying trigeminal mechanisms of neurogenic inflammation.
Topics: Animals; Bradykinin; Calcimycin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Inflammation Mediators; Ionophores; Male; Mouth Mucosa; Neurogenic Inflammation; Nociceptors; Organ Culture Techniques; Pain Measurement; Potassium Chloride; Rats; Rats, Sprague-Dawley; Serotonin; Trigeminal Nerve | 2001 |
Stimulatory effect of centrally injected capsaicin, an agonist of vanilloid receptors, on gastric acid secretion in rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, Drug; Ruthenium; Stomach; Time Factors; Vagotomy; Vagus Nerve | 2001 |
Noxious heat-induced CGRP release from rat sciatic nerve axons in vitro.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Coloring Agents; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Male; Nociceptors; Pain; Potassium; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red; Sciatic Nerve | 2001 |
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cell Division; Glioma; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzoquinones; Bradykinin; Capsaicin; Disease Models, Animal; Female; Indomethacin; Lactic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Propionates; Prostaglandins; Receptors, Drug; Receptors, Prostaglandin | 2001 |
Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.
Topics: Acid Sensing Ion Channels; Acids; Adjuvants, Immunologic; Amiloride; Animals; Calcium; Capsaicin; Chemoreceptor Cells; Cholera Toxin; Diuretics; Dose-Response Relationship, Drug; Female; GTP-Binding Proteins; Male; Membrane Proteins; Nerve Tissue Proteins; Pertussis Toxin; Protons; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sodium Channels; Stimulation, Chemical; Tachyphylaxis; Taste; Taste Buds; Virulence Factors, Bordetella | 2001 |
CH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate.
Topics: Animals; Body Temperature; Capsaicin; Capsicum; Male; Mice; Receptors, Drug; Stimulation, Chemical | 2001 |
Capsaicin-, resiniferatoxin-, and olvanil-induced adrenaline secretions in rats via the vanilloid receptor.
Topics: Adrenal Glands; Animals; Capsaicin; Diterpenes; Epinephrine; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2001 |
Functional vanilloid receptors in cultured normal human epidermal keratinocytes.
Topics: Acids; Calcium; Capsaicin; Cells, Cultured; Epidermal Cells; Epidermis; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Keratinocytes; Receptors, Drug | 2002 |
Pharmacological characterization of vanilloid receptor located in the brain.
Topics: Animals; Binding, Competitive; Brain Chemistry; Capsaicin; Diterpenes; Ganglia, Spinal; Hippocampus; Kinetics; Locus Coeruleus; Macaca fascicularis; Neurons, Afferent; Organ Specificity; Preoptic Area; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Structure-Activity Relationship; TRPV Cation Channels | 2002 |
Relaxant effect of capsazepine in the isolated rat ileum.
Topics: Alkaloids; Animals; Benzodioxoles; Calcium Channels, L-Type; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2002 |
Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers.
Topics: Acetylcholine; Animals; Biological Factors; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Lipoxygenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nerve Fibers; Oligopeptides; Potassium; Potassium Channel Blockers; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Drug; Receptors, Thrombin; Trypsin; Vasodilation | 2002 |
3-D-QSAR analysis of N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline and N-(3-acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thioureas analogues as potent vanilloid receptor ligands.
Topics: Analgesics; Animals; Benzazepines; Capsaicin; Cells, Cultured; Isoquinolines; Ligands; Models, Molecular; Protein Binding; Quantitative Structure-Activity Relationship; Rats; Receptors, Drug; Thiourea | 2002 |
Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors.
Topics: Afferent Pathways; Animals; Arachidonic Acids; Capsaicin; Cardiovascular System; Chemoreceptor Cells; Dose-Response Relationship, Drug; Electrophysiology; Endocannabinoids; Lung; Male; Morpholines; Nerve Fibers; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; TRPV Cation Channels; Vagus Nerve | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |
Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.
Topics: Animals; Capsaicin; Gastric Mucosa; Male; Neural Inhibition; Neurons, Afferent; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Drug; Receptors, Thrombin; TRPV Cation Channels | 2002 |
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Ethanol; Ganglia, Spinal; Hot Temperature; Humans; Male; Neurons, Afferent; Nociceptors; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Drug; Recombinant Proteins; Sensory Thresholds; Substance P; Thermoreceptors; Trigeminal Ganglion; TRPV Cation Channels | 2002 |
Gastric hyperemic response induced by acid back-diffusion in rat stomachs following barrier disruption -- relation to vanilloid type-1 receptors.
Topics: Animals; Capsaicin; Diffusion; Gastric Acid; Gastric Mucosa; Hydrogen; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; Stomach; Stomach Ulcer; Taurocholic Acid; Time Factors; TRPV Cation Channels | 2002 |
A heat-sensitive TRP channel expressed in keratinocytes.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Blotting, Northern; Capsaicin; Cation Transport Proteins; Cell Line; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Epidermal Cells; Epidermis; Ganglia, Spinal; Hot Temperature; Humans; In Situ Hybridization; Ion Channels; Keratinocytes; Membrane Potentials; Mice; Molecular Sequence Data; Nerve Endings; Neurons; Patch-Clamp Techniques; RNA, Messenger; Ruthenium Red; Signal Transduction; Spinal Cord; Temperature; TRPV Cation Channels | 2002 |
Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Guanidines; Indomethacin; Isoenzymes; Liver; Liver Circulation; Male; Membrane Proteins; Miotics; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Peptide Fragments; Peroxidase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reperfusion Injury; Specific Pathogen-Free Organisms; Sulfonamides; Transaminases; Tumor Necrosis Factor-alpha | 2002 |
DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Animals; Capsaicin; Diuretics; FMRFamide; Ganglia, Spinal; Hydrogen-Ion Concentration; Ion Channel Gating; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons, Afferent; Neuropeptides; Protons; Sodium Channels | 2002 |
Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed and carrageenan inflamed rats.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Carrageenan; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Nerve Fibers; Nerve Fibers, Myelinated; Neural Inhibition; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Drug | 2002 |
Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.
Topics: Amino Acid Sequence; Animals; Capsaicin; Hot Temperature; Hyperalgesia; Male; Pain; Peptide Fragments; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin | 2002 |
Comparison of capsaicin-evoked calcium transients between rat nodose and jugular ganglion neurons.
Topics: Animals; Calcium; Capsaicin; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Glomus Jugulare; Neurons; Nodose Ganglion; Rats; Rats, Sprague-Dawley | 2002 |
Effects of peripheral nerve injury on functional spinal VR1 receptors.
Topics: Action Potentials; Animals; Capsaicin; Denervation; Dose-Response Relationship, Drug; Down-Regulation; Hyperalgesia; Ligation; Nerve Fibers; Nerve Fibers, Myelinated; Neuralgia; Neuronal Plasticity; Nociceptors; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Receptors, Drug | 2002 |
Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists.
Topics: Animals; Arachidonic Acids; Bronchi; Bronchial Arteries; Calcium Channel Blockers; Capsaicin; Computer Simulation; Endocannabinoids; Guinea Pigs; Lung; Male; Mesenteric Arteries; Polyunsaturated Alkamides; Receptors, Drug | 2002 |
Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig.
Topics: Action Potentials; Animals; Bicarbonates; Bronchi; Buffers; Capsaicin; Citric Acid; Dose-Response Relationship, Drug; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neurons, Afferent; Nodose Ganglion; Protons; Receptors, Drug; Trachea | 2002 |
Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Castor Oil; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Intestinal Secretions; Intestine, Small; Male; Mice; Mice, Inbred ICR; Organ Size; Piperidines; Polyunsaturated Alkamides | 2002 |
Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius.
Topics: Animals; Baroreflex; Capsaicin; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Head; In Vitro Techniques; Male; Patch-Clamp Techniques; Pressoreceptors; Presynaptic Terminals; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Drug; Receptors, Glutamate; Rhombencephalon; Solitary Nucleus; Synaptic Transmission; Visceral Afferents | 2002 |
Cloning and functional characterization of the guinea pig vanilloid receptor 1.
Topics: Aequorin; Amino Acid Sequence; Animals; Calcium; Capsaicin; CHO Cells; Chronic Disease; Cloning, Molecular; Cricetinae; Fluorescent Dyes; Fura-2; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Luminescent Measurements; Molecular Sequence Data; Pain; Rats; Receptors, Drug; TRPV Cation Channels | 2002 |
Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.
Topics: Acid Sensing Ion Channels; Adult; Amiloride; Animals; Capsaicin; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Proteins; Nerve Tissue Proteins; Nociceptors; Oocytes; Pain; Psychophysics; Rats; Receptors, Drug; Recombinant Proteins; Sodium Channels; Xenopus | 2002 |
The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons.
Topics: Afferent Pathways; Animals; Calcium Signaling; Capsaicin; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Immunohistochemistry; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; Synaptic Transmission; Thermosensing; TRPV Cation Channels | 2002 |
Gingerols: a novel class of vanilloid receptor (VR1) agonists.
Topics: Animals; Animals, Newborn; Calcium; Capsaicin; Catechols; Cells, Cultured; Dose-Response Relationship, Drug; Fatty Alcohols; Fura-2; Ganglia, Spinal; Membrane Potentials; Neurons; Rats; Receptors, Drug; Time Factors | 2002 |
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Topics: Aerosols; Animals; Arachidonic Acids; Calcium; Camphanes; Capsaicin; Cells, Cultured; Consciousness; Cough; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Guinea Pigs; Male; Nodose Ganglion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Upregulation of proinflammatory cytokines and nerve growth factor by intraplantar injection of capsaicin in rats.
Topics: Administration, Topical; Animals; Capsaicin; Cytokines; Denervation; Electric Stimulation; Female; Foot; Inflammation Mediators; Injections; Nerve Growth Factor; Nociceptors; Rats; Sciatic Nerve; Up-Regulation | 2002 |
Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.
Topics: Animals; Animals, Newborn; Calcium; Capsaicin; Crystallography, X-Ray; Indicators and Reagents; Models, Molecular; Molecular Conformation; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Drug; Thiourea | 2003 |
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.
Topics: Algorithms; Animals; Anticonvulsants; Capsaicin; Carbamazepine; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Drug; Sciatic Nerve | 2003 |
Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes.
Topics: Calcium; Calcium Signaling; Capsaicin; Cell Line; Cyclooxygenase 2; Dinoprostone; Humans; Immunoblotting; Inflammation Mediators; Interleukin-8; Isoenzymes; Keratinocytes; Membrane Proteins; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin | 2003 |
Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Male; Neuropeptides; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Somatostatin; Substance P; Trachea | 2003 |
R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Trachea | 2003 |
The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Capsaicin; Electric Stimulation; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; In Vitro Techniques; Medulla Oblongata; Membrane Potentials; Nerve Endings; Patch-Clamp Techniques; Polyunsaturated Alkamides; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 2003 |
Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells.
Topics: Action Potentials; Animals; Arachidonic Acids; Calcium Channels, L-Type; Capsaicin; Cell Line; Delayed Rectifier Potassium Channels; Drug Interactions; Endocannabinoids; Glycerol; Hybrid Cells; Mice; Neurons; omega-Conotoxin GVIA; Pertussis Toxin; Polyunsaturated Alkamides; Potassium Channels; Potassium Channels, Voltage-Gated; Rats | 2003 |
Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Endocannabinoids; Hypertension; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release.
Topics: Air Pollutants; Calcium; Capsaicin; Cell Line; Cyclic AMP; Humans; Interleukin-6; Receptors, Drug; Trigeminal Ganglion | 2003 |
Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats.
Topics: Animals; Capsaicin; Colitis, Ulcerative; Colon; Denervation; Dextran Sulfate; Disease Models, Animal; Neurons, Afferent; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Drug; Severity of Illness Index; TRPV Cation Channels | 2003 |
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Disease Models, Animal; Diterpenes; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Hyperalgesia; Inflammation; Ligation; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Neurons, Afferent; Rats; Receptors, Drug; Spinal Cord; Structure-Activity Relationship; Thiocarbamates | 2003 |
Peripheral tackykinin and excitatory amino acid receptors mediate hyperalgesia induced by Phoneutria nigriventer venom.
Topics: Animals; Capsaicin; Edema; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hindlimb; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spider Venoms | 2003 |
Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro.
Topics: Animals; Atropine; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Hexamethonium; Humans; In Vitro Techniques; Male; Molecular Structure; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Phenylephrine; Rats; Rats, Wistar; Receptors, Tachykinin; Vas Deferens; Vasoconstrictor Agents | 2003 |
Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Capsaicin; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mesencephalon; Neurons; Patch-Clamp Techniques; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Drug; RNA, Messenger; Substantia Nigra; Synapses; Synaptic Transmission; Tetrodotoxin | 2003 |
Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Foot; Injections; Male; Mice; Nociceptors; Pain; Receptors, Drug; Ruthenium Red | 2003 |
The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Calcium; Capsaicin; Cell Line; Fluorescent Dyes; Fura-2; Humans; Rats; Receptors, Drug; Recombinant Proteins | 2003 |
Involvement of capsaicin-sensitive sensory nerves in cardioprotection of rutaecarpine in rats.
Topics: Alkaloids; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Creatine Kinase; Heart; Indole Alkaloids; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neurons, Afferent; Organ Size; Quinazolines; Rats; Rats, Wistar | 2003 |
Adrenergic regulation of capsaicin-sensitive neurons in dental pulp.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cattle; Clonidine; Dental Pulp; Epinephrine; Ion Channels; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Receptors, Adrenergic, alpha; Receptors, Drug | 2003 |
Calcium signaling in single peripheral sensory nerve terminals.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Capsaicin; Cornea; Electric Stimulation; Fluorescent Dyes; In Vitro Techniques; Microscopy, Confocal; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sodium Channel Blockers; Stimulation, Chemical | 2003 |
Mechanisms of sensitization of the response of single dorsal root ganglion cells from adult rat to noxious heat.
Topics: Animals; Capsaicin; Ganglia, Spinal; Hot Temperature; Nerve Growth Factor; Neurons; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptors, Drug; Tachyphylaxis; Type C Phospholipases | 2003 |
Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Hot Temperature; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Male; Organ Culture Techniques; Potassium; Protons; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red; Sciatic Nerve | 2003 |
Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat.
Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Drug Resistance; Dura Mater; Humans; Male; Microscopy, Electron; Neurons, Afferent; Peptide Fragments; Rats; Rats, Wistar; Regional Blood Flow; Vasodilation | 2003 |
Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection.
Topics: Acids; Animals; Capsaicin; Diterpenes; Epithelial Cells; Ethanol; Gastric Mucosa; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; TRPV Cation Channels | 2003 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Antihypertensive Agents; Arachidonic Acids; Benzoxazines; Blood Pressure; Calcium Channel Blockers; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Ganglionic Blockers; Heart Rate; Hemodynamics; Hexamethonium; Injections, Spinal; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Spinal Cord; Urethane | 2003 |
Activation of vanilloid receptor 1 (VR1) by eugenol.
Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cell Line; Chelating Agents; Electrophysiology; Eugenol; Fura-2; Humans; Neurons, Afferent; Patch-Clamp Techniques; Rats; Receptors, Drug; Ruthenium Red; Trigeminal Ganglion | 2003 |
Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.
Topics: Animals; Capsaicin; Cell Line; Cyclooxygenase 2; Dinoprostone; Diterpenes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Ganglia, Spinal; I-kappa B Kinase; Interferon-gamma; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Male; Mitogen-Activated Protein Kinases; Neurotoxins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factor AP-1 | 2003 |
Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea.
Topics: Agaricales; Analgesics; Animals; Bridged Bicyclo Compounds; Calcium; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Phenols; Phytotherapy; Receptors, Drug; Trachea | 2003 |
Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dura Mater; Electric Stimulation; Injections, Intravenous; Male; Microscopy, Video; Neurons, Afferent; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trigeminal Nerve; Vasodilation | 2003 |
Stimulation by capsaicin of duodenal HCO3(-) secretion via afferent neurons and vanilloid receptors in rats: comparison with acid-induced HCO3(-) response.
Topics: Animals; Bicarbonates; Capsaicin; Coloring Agents; Duodenum; Enzyme Inhibitors; Immunohistochemistry; Intestinal Mucosa; Male; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptors, Drug; Regional Blood Flow; Ruthenium Red | 2003 |
Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors.
Topics: Afferent Pathways; Analysis of Variance; Anesthetics, Local; Animals; Axons; Baclofen; Calcium; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Functional Laterality; GABA Agonists; Immunohistochemistry; In Vitro Techniques; Indoles; Isoindoles; Lidocaine; Microscopy, Confocal; Neurokinin-1 Receptor Antagonists; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Spinal Nerve Roots; Time Factors | 2003 |
Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
Topics: Amino Acid Sequence; Animals; Biological Assay; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Fluorescence; Humans; Kinetics; Ligands; Molecular Sequence Data; Rats; Receptors, Drug; Ruthenium Red; Sequence Homology, Amino Acid; Species Specificity | 2002 |
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h).
Topics: Animals; Capsaicin; Cell Death; Cell Hypoxia; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Cytoprotection; Dose-Response Relationship, Drug; Glucose; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons.
Topics: Animals; Capsaicin; Cell Count; Cell Culture Techniques; Cobalt; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Immunohistochemistry; Insulin; Neomycin; Neurons, Afferent; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Receptors, Drug; Ruthenium Red; Staurosporine; TRPV Cation Channels; Type C Phospholipases; Tyrphostins | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Cell Movement; Endocannabinoids; Hyperalgesia; Male; Nerve Growth Factor; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2003 |
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anilides; Aniline Compounds; Animals; Calcium; Capsaicin; Carrier Proteins; Cell Line; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hot Temperature; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Membrane Potentials; N-Methylaspartate; Neuropeptides; Norepinephrine; Orexins; Patch-Clamp Techniques; Protein Binding; Radioligand Assay; Rats; Receptors, Drug; Serotonin Receptor Agonists; Xanthenes | 2004 |
Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population.
Topics: Animals; Binding, Competitive; Calcium; Capsaicin; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Receptors, Calcium-Sensing; Receptors, Drug; Thiourea; TRPV Cation Channels | 2004 |
Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Maze Learning; Rats; Rats, Sprague-Dawley; Receptors, Drug; Swimming | 2004 |
Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bisoprolol; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Carvedilol; Cells, Cultured; Drug Interactions; Female; Humans; Hypertension; Kidney; Male; Mice; Neurons, Afferent; Prazosin; Propanolamines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Regional Blood Flow | 2004 |
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Diterpenes; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Ions; Kinetics; Ligands; Methionine; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenotype; Phorbol Esters; Protein Structure, Tertiary; Rats; Receptors, Drug; Species Specificity; Time Factors | 2004 |
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide.
Topics: Aminobutyrates; Animals; Arachidonic Acid; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Dinoprostone; Diterpenes; Dopamine; Endocannabinoids; Ganglia, Spinal; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Staurosporine; Trigeminal Ganglion; TRPC Cation Channels; TRPV Cation Channels | 2004 |
Multiple actions of anandamide on neonatal rat cultured sensory neurones.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Drug Synergism; Endocannabinoids; Fura-2; Ganglia, Spinal; Neurons, Afferent; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; TRPV Cation Channels | 2004 |
An investigation of the effects of ruthenium red, nitric oxide and endothelin-1 on infrared receptor activity in a crotaline snake.
Topics: Animals; Blood Vessels; Capsaicin; Electrophysiology; Endothelin-1; Female; Male; Nitric Oxide Donors; Nitroprusside; Receptors, Drug; Ruthenium Red; Temperature; Thermoreceptors; Trimeresurus | 2004 |
An efficient parallel synthesis of capsazepine and capsazepine analogs.
Topics: Benzazepines; Capsaicin; Molecular Structure | 2004 |
Characterization of capsaicin-induced, capsazepine-insensitive relaxation of ileal smooth muscle of rats.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Capsaicin; Chelating Agents; Egtazic Acid; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nifedipine; Phosphorylation; Potassium; Rats; Rats, Wistar | 2004 |
Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro.
Topics: Acetylcholine; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Antagonism; Electric Stimulation; Gastrointestinal Motility; Ileum; Male; Organ Culture Techniques; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Zingiber officinale | 2004 |
Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Capsaicin; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Interactions; Electrochemistry; Endocannabinoids; In Vitro Techniques; Ion Channels; Male; Motor Activity; Neurons; Polyunsaturated Alkamides; Potassium; Rats; Rats, Wistar; Receptors, Drug; Stereotyped Behavior; TRPV Cation Channels; Tyrosine 3-Monooxygenase | 2004 |
An assessment of vascular pain using the flexor reflex in anesthetized rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electromyography; Hindlimb; Injections, Intra-Arterial; Injections, Spinal; Injections, Subcutaneous; Lidocaine; Male; Morphine; Muscle, Skeletal; Naloxone; Pain Measurement; Procaine; Rats; Rats, Sprague-Dawley; Reflex, Stretch; Time Factors; Toes; Vascular Diseases | 2004 |
The analgesic effect induced by capsaicin is enhanced in inflammatory states.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Disease Models, Animal; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Receptors, Drug; Time Factors | 2004 |
Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons.
Topics: Animals; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Ganglia, Spinal; Histamine; Lipoxygenase; Neurons, Afferent; Nociceptors; Phospholipases A; Pruritus; Rats; Receptors, Drug | 2004 |
Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Capsaicin; Cell Separation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Presynaptic Terminals; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Purinergic P2; Solitary Nucleus | 2004 |
Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; In Vitro Techniques; Male; Mice; Mice, Knockout; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red; Sensory Receptor Cells; Signal Transduction; Skin | 2004 |
Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Blood Pressure; Camphanes; Capsaicin; Decerebrate State; Disease Models, Animal; Electric Stimulation; Germany; Imidazoles; Infusions, Intravenous; Lipopolysaccharides; Male; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Shock, Septic; Solvents; Thiourea; Vagotomy; Vasomotor System; Vasopressins | 2004 |
Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens.
Topics: Acetylcholine; Animals; Arachidonic Acids; Argentina; Capsaicin; Chile; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Estradiol; Estrogens; Female; Male; Mesentery; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Ovariectomy; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sex Characteristics; Time Factors; Vasodilation | 2004 |
TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Calcium; Capsaicin; Cells, Cultured; Dopamine; Drug Interactions; Electrophysiology; Male; Membrane Potentials; Nerve Fibers; Pain Measurement; Physical Stimulation; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Sensory Thresholds; Spinal Cord | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones.
Topics: Anesthetics, Local; Animals; Arachidonic Acids; Biological Transport; Capsaicin; Drug Interactions; Endocannabinoids; Glutamic Acid; Male; Neurons; Polyunsaturated Alkamides; Rats; Receptors, Drug; Substantia Gelatinosa; Tetrodotoxin | 2004 |
Differential pH and capsaicin responses of Griffonia simplicifolia IB4 (IB4)-positive and IB4-negative small sensory neurons.
Topics: Amiloride; Animals; Calcium; Capsaicin; Diuretics; Ganglia, Spinal; Hydrogen-Ion Concentration; Immunohistochemistry; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Plant Lectins; Protons; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2004 |
Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; In Vitro Techniques; Indomethacin; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus | 2004 |
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Topics: Animals; Calcium; Capsaicin; Cations, Divalent; CHO Cells; Cricetinae; Diterpenes; Ligands; Models, Biological; Molecular Conformation; Molecular Structure; Plant Extracts; Quinazolines; TRPV Cation Channels | 2004 |
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.
Topics: Amiloride; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diterpenes; Diuretics; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Epithelial Sodium Channels; Humans; Hydrogen-Ion Concentration; Neurotoxins; Oocytes; Protein Structure, Tertiary; Protons; Receptors, Drug; Sodium Channels; Xenopus | 2004 |
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Topics: Administration, Oral; Animals; Camphanes; Cannabidiol; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperalgesia; Inflammation; Italy; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Rimonabant; Time Factors | 2004 |
Characterization of the human HCN1 channel and its inhibition by capsazepine.
Topics: Animals; Benzazepines; Capsaicin; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrimidines; Time Factors; Transfection | 2004 |
Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi.
Topics: Adrenergic beta-Agonists; Bronchi; Bronchoconstriction; Capsaicin; Drug Interactions; Endothelin-1; Female; Fenoterol; Humans; Ion Channels; Male; Middle Aged; Nociceptin; Opioid Peptides; Receptors, Drug; TRPV Cation Channels; Vasodilator Agents | 2004 |
Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats.
Topics: Animals; Capsaicin; Cell Line, Tumor; DNA Primers; Ganglia, Spinal; Gene Expression Regulation; Insulin; Insulin Secretion; Insulinoma; Ion Channels; Islets of Langerhans; Male; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; TRPV Cation Channels | 2004 |
Capsazepine elevates intracellular Ca2+ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist.
Topics: Calcium; Calcium Signaling; Capsaicin; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Fluorescent Dyes; Fura-2; Humans; Osteosarcoma; Pyrrolidinones; Receptors, Drug; Thapsigargin; Type C Phospholipases | 2004 |
Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Benzhydryl Compounds; Capsaicin; Cell Division; Cell Survival; Colonic Neoplasms; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Phenols; PPAR gamma; Receptors, Drug; TRPV Cation Channels | 2004 |
Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death.
Topics: Animals; Apoptosis; Calcium Signaling; Capsaicin; Caspases; CD4 Antigens; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Membrane; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Intracellular Membranes; Lymphocyte Subsets; Male; Mitochondria; Necrosis; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Drug; RNA, Messenger; T-Lymphocytes | 2004 |
Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.
Topics: Animals; Body Temperature; Capsaicin; Diterpenes; Eating; Fever; Lipopolysaccharides; Male; Rats; Rats, Long-Evans; Receptors, Drug; TRPV Cation Channels | 2004 |
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Capsaicin; Cation Transport Proteins; CHO Cells; Cricetinae; Endothelium, Vascular; Gadolinium; Ganglia, Sympathetic; Guanethidine; Hydroxyeicosatetraenoic Acids; Ion Channels; Male; Mesenteric Arteries; Mice; Mice, Knockout; Models, Cardiovascular; Models, Neurological; Nerve Fibers, Unmyelinated; Nociceptors; Peptides, Cyclic; Piperidines; Pressure; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ruthenium Red; Sodium Channel Blockers; Splanchnic Circulation; Stress, Mechanical; Sympathectomy, Chemical; Tetrodotoxin; TRPV Cation Channels; Vascular Resistance; Vasoconstriction | 2004 |
Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis.
Topics: Animals; Capsaicin; Colitis; Colon; Nociceptors; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2004 |
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
Topics: Arachidonic Acids; Blood-Brain Barrier; Brain; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Adhesion Molecules; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Glycerides; Humans; Ion Channels; Microcirculation; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; TRPV Cation Channels | 2004 |
Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells.
Topics: Androgens; Apoptosis; Base Sequence; Calcium; Capsaicin; Cell Survival; DNA Primers; Humans; Immunohistochemistry; Ion Channels; Ion Transport; Male; Menthol; Neoplasm Proteins; Prostatic Neoplasms; Sequence Homology, Nucleic Acid; TRPM Cation Channels | 2004 |
Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.
Topics: Action Potentials; Analysis of Variance; Animals; Autonomic Denervation; Calcitonin Gene-Related Peptide; Capsaicin; Drug Interactions; Immunohistochemistry; In Vitro Techniques; Ion Channels; Jejunum; Male; Muscle Relaxation; Myenteric Plexus; Nerve Fibers; Rats; Rats, Wistar; Substance P; TRPV Cation Channels | 2004 |
Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Bronchi; Calcium; Calcium Channels; Capsaicin; Cyclohexanones; Cytochrome P-450 CYP4A; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Intracellular Membranes; Lipoprotein Lipase; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Receptors, Drug; Time Factors; Trachea | 2005 |
Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig.
Topics: Alkaloids; Anaphylaxis; Animals; Antigens; Aorta, Thoracic; Calcitonin Gene-Related Peptide; Capsaicin; Diphenhydramine; Female; Guinea Pigs; Indole Alkaloids; Male; Quinazolines; Receptors, Drug; Time Factors; TRPV Cation Channels; Vasoconstriction; Vasodilator Agents | 2005 |
Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice.
Topics: Animals; Anticoagulants; Capsaicin; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammatory Bowel Diseases; Ion Channels; Mice; Mice, Inbred BALB C; Peroxidase; TRPV Cation Channels | 2004 |
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.
Topics: Acrolein; Animals; Arachidonic Acids; Capsaicin; Cyclophosphamide; Cystitis; Endocannabinoids; Female; Hydrolysis; Ion Channels; Pain; Polyunsaturated Alkamides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex, Abnormal; TRPV Cation Channels; Urinary Bladder | 2004 |
Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Creatine Kinase; Evodia; Infusions, Intravenous; Male; Myocardial Reperfusion Injury; Myocardium; Phytotherapy; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2004 |
TRPV1b, a functional human vanilloid receptor splice variant.
Topics: Amino Acid Sequence; Capsaicin; Cloning, Molecular; Humans; Ion Channels; Molecular Sequence Data; Ruthenium Red; Structure-Activity Relationship; Temperature; Trigeminal Ganglion; TRPV Cation Channels | 2005 |
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.
Topics: Animals; Blood Pressure; Boron Compounds; Capsaicin; Cation Transport Proteins; Coloring Agents; Heart Rate; Ion Channels; Lung; Nerve Fibers, Unmyelinated; Nodose Ganglion; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Respiratory Mechanics; Ruthenium Red; TRPV Cation Channels | 2005 |
Lafutidine-induced increase in intracellular ca(2+) concentrations in PC12 and endothelial cells.
Topics: Acetamides; Animals; Calcium; Calcium Chloride; Capsaicin; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Imidazoles; Immunoblotting; Intracellular Fluid; PC12 Cells; Piperidines; Pyridines; Rats; Thapsigargin; Time Factors | 2005 |
Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat.
Topics: Animals; Capsaicin; Ischemia; Jejunum; Male; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reperfusion Injury; Ruthenium Red; Vagotomy; Vagus Nerve | 2005 |
Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.
Topics: Animals; Capsaicin; Cell Survival; Disease Models, Animal; Electroencephalography; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Memory; Motor Activity; Neuroprotective Agents; Pyramidal Cells; Receptors, Drug | 2005 |
AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Dose-Response Relationship, Drug; Endocannabinoids; Immunohistochemistry; Indoles; Male; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2005 |
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydramine; Diterpenes; Domperidone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Indomethacin; Malates; Methysergide; Metoclopramide; Migraine Disorders; Ondansetron; Piperidines; Ruthenium Red; Scopolamine; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews; Sumatriptan; Time Factors; Tropanes; Vomiting | 2005 |
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1).
Topics: Alkaloids; Benzodioxoles; Capsaicin; Cell Line; Humans; Hydrogen-Ion Concentration; Patch-Clamp Techniques; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Receptors, Drug; Ruthenium Red; Structure-Activity Relationship | 2005 |
Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids.
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ion Channels; Polyunsaturated Alkamides; Rats; Recombinant Proteins; Species Specificity; Temperature; TRPV Cation Channels | 2005 |
Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R).
Topics: Animals; Capsaicin; Ceruletide; Coloring Agents; Evans Blue; Male; Neuritis; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; TRPV Cation Channels | 2005 |
Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxins; Hypotension; Iloprost; Indomethacin; Interleukin-16; Lung; Neurons, Afferent; Nitric Oxide Synthase; Prospective Studies; Rats; Rats, Wistar; Reference Values; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin.
Topics: Adenosine Triphosphate; Amiloride; Amino Acids; Animals; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Ganglia, Spinal; Hydrogen-Ion Concentration; Immunohistochemistry; Lectins; Lumbosacral Region; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Phenols; Polycyclic Compounds; Protons; Purinergic Agonists; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Sodium Channel Blockers; Thoracic Vertebrae; Time Factors; TRPV Cation Channels; Urinary Bladder | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
Vanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscle.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Capsaicin; Cell Line; Gene Expression; Ion Channels; Microscopy, Confocal; Microscopy, Electron; Muscle, Skeletal; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; TRPV Cation Channels | 2005 |
Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cannabidiol; Capsaicin; Drug Interactions; Ear, External; Gastrointestinal Motility; Inflammation; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motor Activity; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2005 |
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; In Vitro Techniques; Isometric Contraction; Male; Mice; Morpholines; Naloxone; Naphthalenes; Phenylephrine; Piperidines; Pyrazoles; Rimonabant; Ruthenium Red; TRPV Cation Channels; Vas Deferens; Yohimbine | 2005 |
Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux.
Topics: Amiloride; Anilides; Animals; Capsaicin; Cell Size; Central Nervous System Depressants; Chorda Tympani Nerve; Cinnamates; Cytosol; Diuretics; Ethanol; Female; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium; Sodium Chloride; Taste; Temperature; Tongue | 2005 |
Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses.
Topics: Algorithms; Amiloride; Anilides; Animals; Capsaicin; Cell Membrane; Cell Polarity; Central Nervous System Depressants; Chorda Tympani Nerve; Cinnamates; Diterpenes; Diuretics; Ethanol; Female; In Vitro Techniques; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium; Sodium Chloride; Stimulation, Chemical; Taste; Taste Threshold; Temperature; Tongue | 2005 |
Characterization of rat transient receptor potential vanilloid 1 receptors lacking the N-glycosylation site N604.
Topics: Analysis of Variance; Animals; Asparagine; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Glycosylation; Humans; Hydrogen-Ion Concentration; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Point Mutation; Rats; Threonine; Transfection; TRPV Cation Channels | 2005 |
Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.
Topics: Analgesics; Anilides; Animals; Capsaicin; Cells, Cultured; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Ion Channels; Male; Mice; Mice, Inbred BALB C; Neurons, Afferent; Nociceptors; Pain; Peripheral Nervous System; Rats; Rats, Wistar; Sensory Receptor Cells; Substance P; Trigeminal Ganglion; TRPV Cation Channels | 2005 |
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.
Topics: Capsaicin; Gramicidin; Kinetics; Lipid Bilayers; Patch-Clamp Techniques; Scattering, Radiation; Sodium Channels | 2005 |
Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat.
Topics: Animals; Blood Pressure; Body Temperature; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Ion Channels; Male; Neurons; Neuropeptides; Rats; Rats, Wistar; Somatostatin; Substance P; Sulfonamides; Thiourea; Trachea; TRPV Cation Channels | 2005 |
Characteristics of propofol-evoked vascular pain in anaesthetized rats.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Animals; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Electromyography; Indomethacin; Injections, Intra-Arterial; Male; Muscle, Skeletal; Pain; Procaine; Propofol; Rats; Rats, Sprague-Dawley; Reflex | 2005 |
Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction.
Topics: Allergens; Animals; Capsaicin; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Ovalbumin; Receptors, Drug; Trachea | 2005 |
Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.
Topics: Adult; Arachidonic Acids; Benzylamines; Capsaicin; Endocannabinoids; Female; Forearm; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Plethysmography; Polyunsaturated Alkamides; Regional Blood Flow; Skin; TRPV Cation Channels | 2005 |
Icilin activates the delta-subunit of the human epithelial Na+ channel.
Topics: Amiloride; Animals; Capsaicin; Epithelial Sodium Channels; Humans; Protons; Pyrimidinones; Sodium Channel Agonists; Sodium Channels; Xenopus laevis | 2005 |
Heat and mechanical hyperalgesia in mice model of cancer pain.
Topics: Animals; Body Temperature; Capsaicin; Cell Count; Cell Line, Tumor; Cell Size; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Pain; Pain Measurement; Pain Threshold; Reaction Time; Staining and Labeling; Time Factors; TRPV Cation Channels | 2005 |
Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons.
Topics: Aldehydes; Animals; Animals, Newborn; Calcium; Capsaicin; Central Nervous System Depressants; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Fluorometry; Neurons; Organic Chemicals; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Trigeminal Ganglion | 2005 |
Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs.
Topics: Administration, Inhalation; Animals; Bradykinin; Bronchial Spasm; Capsaicin; Citric Acid; Cough; Guinea Pigs; Lung; Male; Mechanoreceptors; Microinjections; Nerve Fibers, Unmyelinated; Neurons, Afferent; Nociceptors; Reflex; Substance P; Tachykinins | 2005 |
Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabidiol; Capsaicin; Clozapine; Conditioning, Classical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Mice; Reflex, Startle; Serotonin Antagonists | 2006 |
TRPV1 activation results in disruption of the blood-brain barrier in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Capillary Permeability; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Microspheres; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Starch; Substance P; Tetrazoles; Time Factors; TRPV Cation Channels | 2005 |
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.
Topics: Anilides; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Capsaicin; Cinnamates; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitroarginine; Perfusion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; RNA, Messenger; TRPV Cation Channels; Vasodilation | 2005 |
Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Denervation; Diuresis; Dose-Response Relationship, Drug; Kidney Cortex; Kidney Pelvis; Male; Natriuresis; Neurons, Afferent; Rats; Rats, Wistar; Regional Blood Flow; TRPV Cation Channels | 2005 |
Attenuation of acid induced oesophagitis in VR-1 deficient mice.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Capsaicin; Endocytosis; Esophagitis; Famotidine; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Omeprazole; Peroxidase; Receptors, Neurokinin-1; Severity of Illness Index; TRPV Cation Channels | 2006 |
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Antibodies; Behavior, Animal; Blotting, Western; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Chelating Agents; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Guanethidine; Indoles; Male; Mice; Nociceptors; Pain; Pain Measurement; Peptide Fragments; Propranolol; Protein Kinase C; Ruthenium Red; Salicylates; Sympatholytics; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Carrier Proteins; Cytosol; Endocannabinoids; Male; Medulla Oblongata; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Phospholipases A; Phospholipases A2; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stress, Psychological; TRPV Cation Channels | 2005 |
VR1-mediated depressor effects during high-salt intake: role of anandamide.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Endocannabinoids; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Sodium, Dietary; Time Factors; TRPV Cation Channels | 2005 |
Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Capsaicin; Cold Temperature; Enzyme Activation; Enzyme Inhibitors; Gastric Fundus; Gene Expression; Genistein; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; TRPM Cation Channels | 2005 |
Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Bradykinin; Capsaicin; Cells, Cultured; Cobalt; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endocannabinoids; Enzyme Inhibitors; Inflammation Mediators; Neurons, Afferent; Nociceptors; Polyunsaturated Alkamides; Protein Kinase C; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Type C Phospholipases | 2005 |
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Attention Deficit Disorder with Hyperactivity; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocannabinoids; Mice; Mice, Knockout; Motor Activity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Serotonin; Signal Transduction; TRPV Cation Channels | 2006 |
Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Baroreflex; Blood Pressure; Capsaicin; Decerebrate State; Diterpenes; Dose-Response Relationship, Drug; Hindlimb; Male; Membrane Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Neurons, Afferent; Phosphoric Acids; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Sympathetic Nervous System; TRPV Cation Channels | 2006 |
TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Capsaicin; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Pain; Pain Measurement; TRPV Cation Channels | 2005 |
Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice.
Topics: Analgesics; Analysis of Variance; Animals; Bone Neoplasms; Capsaicin; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Freund's Adjuvant; Functional Laterality; Inflammation; Mice; Mice, Inbred C3H; Osteosarcoma; Pain; Pain Measurement; Reaction Time; Time Factors | 2006 |
Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells.
Topics: Calcium; Capsaicin; Cell Line, Tumor; Cell Proliferation; Cytosol; Dose-Response Relationship, Drug; Egtazic Acid; Humans; Male; Prostatic Neoplasms; TRPV Cation Channels; Type C Phospholipases | 2006 |
TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice.
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Heart; In Vitro Techniques; Mice; Mice, Knockout; Myocardial Ischemia; Neurokinin-1 Receptor Antagonists; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Recovery of Function; Reperfusion Injury; Substance P; TRPV Cation Channels | 2005 |
Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine.
Topics: Acetylcholine; Animals; Capsaicin; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Receptors, Cell Surface; TRPV Cation Channels | 2006 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Charybdotoxin; Diclofenac; Dimethyl Sulfoxide; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitroarginine; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; rho-Associated Kinases; Tetraethylammonium; Vasodilator Agents | 2006 |
A novel mechanism contributing to development of Dahl salt-sensitive hypertension: role of the transient receptor potential vanilloid type 1.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Hypertension; Injections, Intravenous; Kidney; Male; Mesenteric Arteries; Neurons, Afferent; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; TRPV Cation Channels; Vascular Resistance | 2006 |
Stimulation by bradykinin of HCO3- secretion in rat gastroduodenal mucosa.
Topics: Animals; Bicarbonates; Bradykinin; Bradykinin B2 Receptor Antagonists; Capsaicin; Duodenum; Enzyme Inhibitors; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Rats, Sprague-Dawley | 2006 |
Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin.
Topics: Androgens; Animals; Apoptosis; Capsaicin; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Reactive Oxygen Species; Transplantation, Heterologous; TRPV Cation Channels | 2006 |
Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.
Topics: Animals; Bone Marrow Cells; Capsaicin; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Dronabinol; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hallucinogens; Interleukin-12; Legionella pneumophila; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Pertussis Toxin; Protein Subunits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; RNA, Messenger; TRPV Cation Channels | 2006 |
Characterization of acid signaling in rat vagal pulmonary sensory neurons.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Animals; Capsaicin; Evoked Potentials; Hydrogen-Ion Concentration; Jugular Veins; Lung; Membrane Proteins; Nerve Tissue Proteins; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Channel Blockers; Sodium Channels; Stimulation, Chemical; TRPV Cation Channels | 2006 |
Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.
Topics: Animals; Avoidance Learning; Brain Ischemia; Cannabinoid Receptor Antagonists; Capsaicin; Electroencephalography; Gerbillinae; Male; Motor Activity; Neuroprotective Agents; Piperidines; Pyrazoles; Rimonabant; TRPV Cation Channels | 2006 |
Methanandamide hyperpolarizes gastric arteries by stimulation of TRPV1 receptors on perivascular CGRP containing nerves.
Topics: Abdomen; Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Electrophysiology; Female; Kinetics; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Muscle, Smooth, Vascular; Peripheral Nervous System; Rats; Rats, Wistar; Receptors, Drug; TRPV Cation Channels | 2006 |
Ethanol dilates coronary arteries and increases coronary flow via transient receptor potential vanilloid 1 and calcitonin gene-related peptide.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethanol; Guinea Pigs; Humans; Peptide Fragments; Perfusion; Receptors, Calcitonin Gene-Related Peptide; Regional Blood Flow; Swine; Tissue Culture Techniques; TRPV Cation Channels; Vasodilator Agents | 2006 |
Participation of the spinal TRPV1 receptors in formalin-evoked pain transduction: a study using a selective TRPV1 antagonist, iodo-resiniferatoxin.
Topics: Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; TRPV Cation Channels | 2006 |
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
Topics: Animals; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Diterpenes; Guinea Pigs; Indomethacin; Inflammation; Isoquinolines; Male; Neurons, Afferent; Protein Kinase C; Protein Kinase Inhibitors; Receptor, PAR-2; Saline Solution, Hypertonic; Sulfonamides; TRPV Cation Channels; Trypsin | 2006 |
Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats.
Topics: Adenosine Deaminase; Adenosine Triphosphate; Animals; Apyrase; Arachidonic Acid; Capsaicin; Cyclooxygenase Inhibitors; Hydrogen Peroxide; Hyperventilation; Hypoventilation; Indomethacin; Lipoxygenase Inhibitors; Male; Oxidants; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Purinergic P2; Receptors, Purinergic P2X; Reflex; Respiratory Mechanics; TRPV Cation Channels | 2006 |
Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats.
Topics: Amidohydrolases; Anilides; Animals; Arachidonic Acids; Body Temperature; Capsaicin; Cinnamates; Endocannabinoids; Hypothermia; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; TRPV Cation Channels | 2006 |
Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Calcium; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Histamine H2 Antagonists; Humans; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Piperidines; Prostaglandins; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Stomach; Stomach Diseases; TRPV Cation Channels | 2006 |
Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Atropine; Bronchi; Bronchodilator Agents; Capsaicin; Cholinergic Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Histamine; Humans; In Vitro Techniques; Indomethacin; Leukotriene D4; Molecular Structure; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Peptides; Potassium Channels, Calcium-Activated; Propranolol; Prostaglandin D2; TRPV Cation Channels; Vasodilator Agents | 2007 |
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Disease Models, Animal; Endocannabinoids; Endotoxins; Ganglia, Spinal; Gene Expression Regulation; Hypotension; Indoles; Indomethacin; Lung; Male; Neurons, Afferent; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2006 |
Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors.
Topics: Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Endothelin-1; Injections, Subcutaneous; Male; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Endothelin A; Touch; TRPV Cation Channels | 2006 |
Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig.
Topics: Animals; Capsaicin; Cochlea; Cochlear Microphonic Potentials; Cochlear Nerve; Evoked Potentials, Auditory; Female; Guinea Pigs; Male; Perfusion; TRPV Cation Channels | 2006 |
Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.
Topics: Air Pollutants; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Capsaicin; Female; Hydrogen Sulfide; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Neurokinin-1 Receptor Antagonists; Peroxidase; Pneumonia; Protein Precursors; Substance P; Tachykinins; TRPV Cation Channels | 2006 |
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Benzyl Compounds; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Levodopa; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reserpine; Signal Transduction; TRPV Cation Channels | 2006 |
Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.
Topics: Amiloride; Animals; Benzolamide; Blood Flow Velocity; Capsaicin; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Duodenum; Epithelial Cells; Gene Expression; Hydrogen-Ion Concentration; Hyperemia; Intestinal Mucosa; Intracellular Fluid; Laser-Doppler Flowmetry; Male; Methazolamide; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sodium-Calcium Exchanger; TRPV Cation Channels | 2006 |
TRPV1 receptors and nasal trigeminal chemesthesis.
Topics: Animals; Calcium; Capsaicin; Cell Line; Humans; Irritants; Male; Rats; Rats, Sprague-Dawley; Smell; Stimulation, Chemical; Transfection; Trigeminal Nerve; TRPV Cation Channels | 2006 |
Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release.
Topics: Animals; Blotting, Western; Calcium; Capsaicin; Cell Death; Cell Line; Cytochromes c; Diterpenes; Enzyme Inhibitors; Humans; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Microglia; Mitochondria; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; TRPV Cation Channels | 2006 |
Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Capsaicin; Endocannabinoids; Male; Migraine Disorders; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Trigeminal Nerve; TRPV Cation Channels | 2007 |
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Edema; Endocannabinoids; Formaldehyde; Ibuprofen; Lactones; Male; Mass Spectrometry; Nitrobenzenes; Pain Measurement; Peripheral Nervous System; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sulfonamides; Sulfones; TRPV Cation Channels | 2006 |
Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Analgesics, Non-Narcotic; Animals; Benzaldehydes; Calcium; Calcium Radioisotopes; Capsaicin; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cholinergic Agonists; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Histamine; Ion Transport; Ruthenium Red; Signal Transduction; Sodium; Sodium Radioisotopes; TRPV Cation Channels; Tyrosine 3-Monooxygenase; Veratridine | 2006 |
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.
Topics: Animals; Binding, Competitive; Calcium; Capsaicin; Cell Line; Cell Membrane; Diterpenes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Hydrogen-Ion Concentration; Linoleic Acid; Male; Membrane Fluidity; Membrane Potentials; Mice; Mice, Inbred C57BL; Oocytes; Pain; Rats; RNA, Complementary; TRPV Cation Channels; Xenopus laevis | 2007 |
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Topics: Animals; Arachidonic Acids; Bile Ducts; Blood Flow Velocity; Blood Pressure; Blotting, Western; Capsaicin; Cardiac Output; Disease Models, Animal; Endocannabinoids; Hyperemia; Indoles; Liver Circulation; Liver Cirrhosis, Biliary; Male; Mesenteric Artery, Superior; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Circulation; Time Factors; TRPV Cation Channels; Vascular Resistance; Vasodilation; Vasodilator Agents | 2006 |
Differential mechanisms mediating depressor and diuretic effects of anandamide.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcium Channel Blockers; Capsaicin; Diuresis; Dose-Response Relationship, Drug; Endocannabinoids; Kidney; Kidney Medulla; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2006 |
Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function.
Topics: Animals; Aorta, Thoracic; Calcitonin Gene-Related Peptide; Capsaicin; Cell Survival; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Heat Stress Disorders; Humans; Lysophosphatidylcholines; Male; Mesenteric Arteries; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; TRPV Cation Channels; Vasodilation | 2007 |
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
Topics: Administration, Oral; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabis; Capsaicin; Chronic Disease; Dinoprostone; Freund's Adjuvant; Hyperalgesia; Inflammation; Lipid Peroxides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Sciatic Neuropathy; Tumor Necrosis Factor-alpha | 2007 |
Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death.
Topics: Anilides; Animals; Apoptosis; Capsaicin; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lung Neoplasms; Membrane Potentials; Mitochondria, Heart; Oxygen Consumption; Rats; TRPV Cation Channels | 2007 |
Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels.
Topics: Animals; Aspartic Acid; Batrachotoxins; Brain; Capsaicin; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Potassium Chloride; Sodium Channels; Synaptosomes; Tritium; TRPV Cation Channels; Veratridine | 2007 |
Mouse colon sensory neurons detect extracellular acidosis via TRPV1.
Topics: Acidosis; Amiloride; Animals; Capsaicin; Cell Size; Cells, Cultured; Colon; Evoked Potentials; Extracellular Fluid; Ganglia, Spinal; Hydrogen-Ion Concentration; Kinetics; Lumbosacral Plexus; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pain; Patch-Clamp Techniques; Sodium Channel Blockers; Thoracic Nerves; TRPV Cation Channels | 2007 |
TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Female; Indicators and Reagents; Mechanotransduction, Cellular; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pressure; Rats; Rats, Wistar; Ruthenium Red; Stress, Mechanical; TRPV Cation Channels; Urinary Bladder | 2007 |
Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzamides; Blood Vessels; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flurbiprofen; Hindlimb; Indoles; Joints; Morpholines; Polyunsaturated Alkamides; Pyrazoles; Rats; Regional Blood Flow; TRPV Cation Channels; Vasodilation | 2007 |
Heat sensitization in skin and muscle nociceptors expressing distinct combinations of TRPV1 and TRPV2 protein.
Topics: Animals; Capsaicin; Colon; Histocytochemistry; Hot Temperature; Male; Muscle, Skeletal; Muscle, Smooth; Muscles; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neurofilament Proteins; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Skin; TRPV Cation Channels | 2007 |
Pharmacological characterisation of capsaicin-induced relaxations in human and porcine isolated arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Cyclic AMP; Dipeptides; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Chloride; Protein Kinase Inhibitors; Quinazolines; Swine; Vasodilation | 2007 |
Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Capsaicin; Capsicum; Cell Proliferation; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Ethanol; Interferon-gamma; Interleukin-2; Male; Mice; Mice, Inbred C57BL; Peyer's Patches; Plant Extracts; T-Lymphocyte Subsets; TRPV Cation Channels | 2007 |
Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells.
Topics: Analgesics, Non-Narcotic; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; TRPV Cation Channels | 2007 |
Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Capsaicin; Endocannabinoids; Hypertension; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sodium Chloride, Dietary; TRPV Cation Channels | 2007 |
Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Humans; Membrane Potentials; Mustard Plant; Neurons; Plant Oils; Rats; Recombinant Proteins; Sus scrofa; Swine; TRPV Cation Channels | 2007 |
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
Topics: Animals; Arachidonate 12-Lipoxygenase; Calcium; Capsaicin; Cells, Cultured; Enzyme Activation; Ganglia, Spinal; Histamine; Mice; Mice, Inbred C57BL; Neurons; Phospholipases A; Phospholipases A2; Rats; TRPV Cation Channels | 2007 |
Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging.
Topics: Animals; Aza Compounds; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Cromolyn Sodium; Goblet Cells; Lung; Magnetic Resonance Imaging; Male; Mucus; Neurons, Afferent; Rats; Rats, Inbred BN; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Time Factors; TRPV Cation Channels | 2007 |
Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95.
Topics: Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Calcium Channel Blockers; Capsaicin; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene D4; Lung; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Tetrahydroisoquinolines | 2008 |
Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.
Topics: Arachidonic Acids; Calcium; Calcium Signaling; Capsaicin; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dopamine; Endocannabinoids; Humans; Models, Biological; Neuroblastoma; Neurons; Norepinephrine; Polyunsaturated Alkamides; Recombinant Proteins; Synaptic Transmission; Transfection; TRPV Cation Channels; Up-Regulation | 2007 |
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels | 2007 |
Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes.
Topics: Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Gene Expression Regulation; Hot Temperature; Humans; Keratinocytes; Male; Matrix Metalloproteinase 1; RNA, Messenger; RNA, Small Interfering; Ruthenium Red; TRPV Cation Channels | 2007 |
Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.
Topics: 6-Ketoprostaglandin F1 alpha; Anilides; Animals; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Cells, Cultured; Cinnamates; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Indomethacin; Male; Neurons, Afferent; Peroxidase; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord; Spinal Cord Diseases; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2007 |
Transient receptor potential vanilloid 1 antagonist, capsazepine, improves survival in a rat hemorrhagic shock model.
Topics: Analysis of Variance; Animals; Capsaicin; Catecholamines; Disease Models, Animal; Dose-Response Relationship, Drug; Immunoenzyme Techniques; Male; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Survival Rate | 2007 |
The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level.
Topics: Analgesics; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Hyperalgesia; Injections, Spinal; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Cord; TRPV Cation Channels | 2008 |
Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Opioid; Ruthenium Red; Signal Transduction; Snails; TRPV Cation Channels | 2007 |
Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?
Topics: Animal Testing Alternatives; Calcium; Calcium Signaling; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Eye Diseases; Fluorescent Antibody Technique, Indirect; Humans; Irritants; Neuroblastoma; Neurons, Afferent; Sodium Dodecyl Sulfate; Surface-Active Agents; TRPV Cation Channels | 2007 |
Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Capsaicin; Chelating Agents; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Egtazic Acid; Endocannabinoids; Extracellular Fluid; Ganglia, Spinal; Hot Temperature; Neurons; Physical Stimulation; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2007 |
Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder.
Topics: Acetylcholine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Oligopeptides; Rats; Rats, Wistar; Receptor, PAR-2; Trypsin; Urinary Bladder | 2007 |
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels | 2007 |
Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor.
Topics: Amides; Calcium; Capsaicin; Cells, Cultured; Fatty Acids; Humans; Kidney; Recombinant Proteins; Tetrahydroisoquinolines; TRPV Cation Channels | 2007 |
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.
Topics: Action Potentials; Animals; Capsaicin; Hydrochloric Acid; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pressure; Time Factors; TRPV Cation Channels; Urinary Bladder | 2007 |
A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Capsaicin; Cell Membrane; Colitis; Curcumin; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Oocytes; Peroxidase; Severity of Illness Index; TRPV Cation Channels; Xenopus | 2007 |
The anandamide transport inhibitor AM404 reduces ethanol self-administration.
Topics: Alcohol Drinking; Animals; Arachidonic Acids; Capsaicin; Central Nervous System Depressants; Conditioning, Operant; Depression, Chemical; Endocannabinoids; Ethanol; Extinction, Psychological; Hypothermia; Male; Motor Activity; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reinforcement, Psychology; Saccharin; Self Administration; TRPV Cation Channels | 2007 |
Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic AMP; Ganglia, Spinal; Hypertension; Insulin-Like Growth Factor I; Neurons, Afferent; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2008 |
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation | 2007 |
TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.
Topics: Afferent Pathways; Animals; Capsaicin; Diuresis; Dose-Response Relationship, Drug; In Vitro Techniques; Indoles; Isoindoles; Kidney; Kidney Pelvis; Male; Natriuresis; Neurokinin-1 Receptor Antagonists; Perfusion; Potassium Chloride; Rats; Rats, Wistar; Saline Solution, Hypertonic; Solutions; TRPV Cation Channels | 2007 |
Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Body Temperature; Capsaicin; Cells, Cultured; Chickens; Fever; Lipopolysaccharides; Macrophages, Peritoneal; Male; Nitric Oxide; Nitrites; Time Factors; TRPV Cation Channels | 2007 |
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
Topics: Amides; Analysis of Variance; Animals; Animals, Newborn; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Patch-Clamp Techniques; Plant Extracts; Rats; Rats, Sprague-Dawley; Taste; Transfection; Transient Receptor Potential Channels; TRPV Cation Channels | 2007 |
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Methoxamine; Neurons, Afferent; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ruthenium Red; Time Factors; Vasodilation | 2007 |
Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor.
Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Hydrogen-Ion Concentration; Male; Membrane Proteins; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Nerve Tissue Proteins; Poisons; Receptors, Tachykinin; Sensory Receptor Cells; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Trachea; TRPV Cation Channels | 2007 |
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.
Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Basal Ganglia; Benzamides; Benzoxazines; Cannabinoids; Capsaicin; Carbamates; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Endocannabinoids; Levodopa; Male; Morpholines; Naphthalenes; Oxidopamine; Parkinson Disease, Secondary; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2007 |
Voltage is a partial activator of rat thermosensitive TRP channels.
Topics: Allosteric Regulation; Animals; Capsaicin; Cell Line; Diterpenes; Electric Stimulation; Hot Temperature; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Models, Chemical; Neurons, Afferent; Protein Kinase C; Rats; Sensory System Agents; TRPM Cation Channels; TRPV Cation Channels | 2007 |
Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Chloride Channels; Hydrogen-Ion Concentration; Ibuprofen; Male; Rats; Rats, Wistar; Sertoli Cells; TRPV Cation Channels | 2008 |
Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.
Topics: Analgesics; Animals; Bicuculline; Calcitonin Gene-Related Peptide; Capsaicin; Edema; GABA Antagonists; Injections, Intradermal; Neurogenic Inflammation; Peptide Fragments; Rats; Receptors, Neurokinin-1; Reflex; Spinal Nerve Roots; Substance P; TRPV Cation Channels; Vasodilation | 2007 |
Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.
Topics: Animals; Arginine; Capsaicin; Diazoxide; Dose-Response Relationship, Drug; Ethanol; Glyburide; Indomethacin; Inositol; KATP Channels; Male; Mice; Misoprostol; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Prostaglandins; Stomach Ulcer | 2008 |
Involvement of peripheral TRPV1 in TMJ hyperalgesia induced by ethanol withdrawal.
Topics: Animals; Capsaicin; Central Nervous System Depressants; Ethanol; Formaldehyde; Male; Pain Measurement; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Temporomandibular Joint Dysfunction Syndrome; TRPV Cation Channels | 2007 |
Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dopamine; Male; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Rimonabant; Sodium Chloride, Dietary; TRPV Cation Channels | 2007 |
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2008 |
Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.
Topics: Action Potentials; Animals; Blood Pressure; Capsaicin; Cell Membrane; Cytosol; Diterpenes; Electrophysiology; Female; Kidney; Kidney Pelvis; Mechanoreceptors; Models, Biological; Neurokinin-1 Receptor Antagonists; Perfusion; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase | 2008 |
SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring.
Topics: Bronchodilator Agents; Capsaicin; Catechols; Chlorine Compounds; Humans; Molecular Structure; Respiration; Structure-Activity Relationship | 2008 |
SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure.
Topics: Bronchodilator Agents; Capsaicin; Catechols; Humans; Models, Molecular; Molecular Structure; Respiration; Structure-Activity Relationship | 2008 |
TRPM8 mechanism of cold allodynia after chronic nerve injury.
Topics: Animals; Capsaicin; Cells, Cultured; Chronic Disease; Cold Temperature; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Menthol; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Skin; TRPM Cation Channels | 2007 |
Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.
Topics: Acrylamides; Animals; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Evoked Potentials; Hexamethonium; Hydrogen-Ion Concentration; Hyperthermia, Induced; Lung; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Temperature; TRPV Cation Channels; Vagus Nerve | 2008 |
Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes.
Topics: Action Potentials; Air Pollutants; Animals; Autonomic Nervous System; Capsaicin; Drug Interactions; Edema; Edema, Cardiac; Heart Diseases; Heart Rate; Inhalation Exposure; Lipid Peroxidation; Oxidative Stress; Particle Size; Particulate Matter; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2008 |
Capsazepine, a synthetic vanilloid that converts the Na,K-ATPase to Na-ATPase.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Capsaicin; Cation Transport Proteins; Cations, Monovalent; Kinetics; Ligands; Sodium; Sodium-Potassium-Exchanging ATPase | 2008 |
SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region).
Topics: Bronchodilator Agents; Capsaicin; Chlorine Compounds; Humans; Hydrophobic and Hydrophilic Interactions; Lipids; Molecular Structure; Respiration; Structure-Activity Relationship; Thiourea | 2008 |
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Topics: Analgesics; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Isothiocyanates; Male; Mice; Pain; Pain Measurement; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2008 |
Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colorimetry; Dose-Response Relationship, Drug; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Sodium; Substance P; TRPV Cation Channels | 2008 |
TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.
Topics: Animals; Apoptosis; Arthritis, Experimental; Calcium; Capsaicin; Cytosol; Fibroblasts; Hyperplasia; Male; Membrane Potential, Mitochondrial; NADPH Oxidases; Onium Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Synovial Membrane; TRPV Cation Channels | 2008 |
TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.
Topics: Animals; Blood Pressure; Capsaicin; Catecholamines; Endotoxins; Heart Rate; Hypotension; Isoindoles; Lipopolysaccharides; Male; Neurons, Afferent; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; TRPV Cation Channels | 2008 |
Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries.
Topics: Acetamides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Drug Synergism; Electric Stimulation; Male; Mesenteric Arteries; Peripheral Nervous System; Piperidines; Pyridines; Rats; Rats, Wistar; Ruthenium Red; TRPV Cation Channels; Vasodilation | 2008 |
Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells.
Topics: Calcium; Capsaicin; Cell Line; Coloring Agents; Epithelium, Corneal; Gene Knockdown Techniques; Humans; Hypotonic Solutions; Isotonic Solutions; Ringer's Solution; RNA, Small Interfering; Ruthenium Red; TRPV Cation Channels | 2008 |
Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Ganglia, Spinal; Isoindoles; Kidney Pelvis; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Quinuclidines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Substance P; TRPV Cation Channels | 2008 |
Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.
Topics: Animals; Calcium; Capsaicin; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Male; Manganese; Metabolic Syndrome; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Obesity; Potassium Channel Blockers; Potassium Channels; Swine; Swine, Miniature; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2008 |
Segmental regulation of sodium and water excretion by TRPV1 activation in the kidney.
Topics: Animals; Blood Pressure; Body Water; Capsaicin; Cations, Monovalent; Creatinine; Glomerular Filtration Rate; Kidney; Lithium; Lithium Chloride; Male; Natriuresis; Nerve Fibers; Rats; Rats, Wistar; Renal Circulation; Sodium; TRPV Cation Channels | 2008 |
Role of TRPV1 channels in renal haemodynamics and function in Dahl salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Capsaicin; Disease Models, Animal; Glomerular Filtration Rate; Hypertension; Kidney; Rats; Rats, Inbred Dahl; Sodium; TRPV Cation Channels | 2008 |
Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory.
Topics: Anilides; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Memory; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Space Perception; Synaptic Transmission; TRPV Cation Channels | 2008 |
Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Foot Diseases; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Neoplasms, Experimental; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred F344; Ruthenium Red; TRPV Cation Channels | 2008 |
In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.
Topics: Androstadienes; Animals; Anti-Inflammatory Agents; Aza Compounds; Benzamides; Bronchoalveolar Lavage Fluid; Budesonide; Capsaicin; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Lung; Magnetic Resonance Imaging; Male; Mast Cells; Naphthoquinones; ortho-Aminobenzoates; p-Methoxy-N-methylphenethylamine; Proteins; Pulmonary Edema; Rats; Rats, Inbred BN; Respiratory System Agents; Time Factors; Wortmannin | 2008 |
The analgesic drug, tramadol, acts as an agonist of the transient receptor potential vanilloid-1.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Cytophotometry; Dose-Response Relationship, Drug; Tachyphylaxis; Tramadol; Transfection; TRPV Cation Channels; Up-Regulation | 2008 |
SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pyridines; Rats; Rats, Inbred Lew; Somatostatin; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Urea | 2008 |
Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1.
Topics: Acid Sensing Ion Channels; Adenosine Triphosphate; Amiloride; Analysis of Variance; Animals; Calcium; Capsaicin; Cells, Cultured; Cnidarian Venoms; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Hydrogen-Ion Concentration; Lactic Acid; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nerve Tissue Proteins; Neurons; Protons; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X; Sodium Channels; TRPV Cation Channels | 2008 |
Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats.
Topics: Animals; Capsaicin; Chronic Disease; Electric Stimulation; Evoked Potentials; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Male; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2008 |
Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Calcium; Capsaicin; Cells, Cultured; CREB-Binding Protein; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Humans; Mice; Mice, Inbred C57BL; Neurons; Pregnancy; Ruthenium Red; Sodium Channel Blockers; Spinal Cord; Tetrodotoxin; TRPV Cation Channels | 2008 |
Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide.
Topics: Calcitonin Gene-Related Peptide; Capsaicin; Cell Survival; Cells, Cultured; Culture Media; Endothelial Cells; Endothelium, Vascular; Fever; Humans; Lysophosphatidylcholines; Radioimmunoassay; RNA, Messenger; TRPV Cation Channels; Umbilical Veins | 2008 |
Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Capsaicin; Hippocampus; Male; Maze Learning; Rats; Rats, Wistar; TRPV Cation Channels | 2008 |
TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Muscle, Smooth; Neurons, Afferent; Pelvic Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; TRPV Cation Channels; Uterus | 2008 |
CO2 chemosensing in rat oesophagus.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Benzolamide; Capsaicin; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Epithelial Cells; Esophageal pH Monitoring; Esophagus; Gastroesophageal Reflux; Hyperemia; Male; Methazolamide; Mucous Membrane; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Sodium Channels; TRPV Cation Channels | 2008 |
Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Arachidonic Acids; Behavior, Animal; Cannabidiol; Capsaicin; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Injections, Intraventricular; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; TRPV Cation Channels | 2008 |
[Protective effect of capsaicin on against myocardial ischemia-reperfusion injury of rat in vivo].
Topics: Animals; Capsaicin; Creatine Kinase, MB Form; Heart Rate; Male; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2008 |
Excitatory and inhibitory urinary bladder reflexes induced by stimulation of cervicovaginal capsaicin-sensitive sensory fibers in rats.
Topics: Animals; Atropine; Capsaicin; Cervix Uteri; Female; Ganglionectomy; Guanethidine; Hexamethonium; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Rats; Rats, Wistar; Reflex; Sensory Receptor Cells; TRPV Cation Channels; Urinary Bladder; Urination; Vagina | 2009 |
TRPV1 channels facilitate glutamate transmission in the striatum.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Endocannabinoids; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Polyunsaturated Alkamides; Protein Kinase C; Sensory System Agents; Synaptic Transmission; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2009 |
Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Corticosterone; Defecation; Electromyography; Endocannabinoids; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Microscopy, Fluorescence; Models, Animal; Morpholines; Naphthalenes; Pain Threshold; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spectrum Analysis; Stress, Psychological; TRPV Cation Channels | 2009 |
Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.
Topics: Administration, Topical; Animals; Antipruritics; Capillary Leak Syndrome; Capsaicin; Cell Degranulation; Disinfectants; Dose-Response Relationship, Drug; Formaldehyde; Hydrocarbons, Aromatic; Ketotifen; Male; Mast Cells; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Regional Blood Flow; Skin | 2009 |
Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells.
Topics: Anilides; Capsaicin; Capsicum; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; Diterpenes; Gene Silencing; Humans; Male; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Prostate; Receptors, Androgen; RNA, Small Interfering; TRPV Cation Channels | 2009 |
Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Capsaicin; Conflict, Psychological; Dose-Response Relationship, Drug; Drinking; Male; Maze Learning; Periaqueductal Gray; Rats; Rats, Wistar; Time Factors; TRPV Cation Channels | 2009 |
Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Hypertension; Hypotension; Kidney; Male; Mesenteric Arteries; Phorbol Esters; Rats; Rats, Wistar; Ruthenium Red; Salt Tolerance; Sodium Chloride, Dietary; Substance P; TRPV Cation Channels | 2009 |
Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.
Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Intracellular Fluid; Mice; Nefopam; Potassium Chloride; Rats; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels | 2009 |
Antiaversive effects of cannabinoids: is the periaqueductal gray involved?
Topics: Animals; Anti-Anxiety Agents; Cannabidiol; Cannabinoids; Capsaicin; Microinjections; Periaqueductal Gray; Rats; Receptor, Cannabinoid, CB1; Stress, Physiological; Synaptic Transmission; TRPV Cation Channels | 2009 |
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.
Topics: Animals; Arachidonic Acids; Boron Compounds; Capsaicin; Cations; Corpus Striatum; Dopamine; Endocannabinoids; Glutamic Acid; Ion Channels; Ligands; Male; Mice; Mice, Mutant Strains; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; TRPV Cation Channels | 2009 |
Nociceptive vascular reflexes evoked by scorpion venom modulate cardiorespiratory parameters involving vanilloid receptor 1 in anaesthetised rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Blood Vessels; Capsaicin; Cardiovascular Physiological Phenomena; Drug Interactions; Heart Rate; Injections, Intra-Arterial; Lidocaine; Male; Nociceptors; Rats; Receptors, Serotonin, 5-HT3; Reflex; Respiratory Physiological Phenomena; Scorpion Venoms; Sensory Receptor Cells; Serotonin; Time Factors; TRPV Cation Channels; Visceral Afferents | 2009 |
Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Capsaicin; Chemokine CCL2; Denervation; Immunohistochemistry; Indomethacin; Kidney; Kidney Diseases; Male; Peptide Fragments; Peroxidase; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Sensory Receptor Cells; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2009 |
Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.
Topics: Animals; Capsaicin; Glutamic Acid; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sensory System Agents; Time Factors; TRPV Cation Channels | 2009 |
A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells.
Topics: Base Sequence; Calcium Signaling; Capsaicin; Cell Line; DNA, Complementary; Humans; Keratinocytes; Matrix Metalloproteinase 1; Models, Biological; Protein Kinase C; RNA, Messenger; RNA, Small Interfering; Skin; Skin Aging; Transfection; TRPV Cation Channels; Ultraviolet Rays | 2009 |
Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.
Topics: Action Potentials; Anilides; Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Cinnamates; Dose-Response Relationship, Drug; Endocannabinoids; Hindlimb; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Skin; Tibial Nerve; TRPV Cation Channels | 2009 |
Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide.
Topics: Amides; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Ethanolamines; Heart Rate; Injections, Spinal; Male; Palmitic Acids; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2009 |
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Capsaicin; Efferent Pathways; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Pyridazines; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Tetrodotoxin; Vagus Nerve | 2009 |
Ethanol aggravates itch-related scratching in hairless mice developing atopic dermatitis.
Topics: Administration, Oral; Animals; Capsaicin; Dermatitis, Atopic; Dibucaine; Ethanol; Female; Mice; Mice, Hairless; N-Methylaspartate; Naltrexone; Petrolatum; Pruritus; Skin Temperature | 2009 |
Functional type I vanilloid receptor expression by substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Capsaicin; Central Nervous System Stimulants; Convulsants; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Membrane Potentials; Mice; Neurokinin-1 Receptor Antagonists; Neurons; Picrotoxin; Sensory System Agents; Sodium Channel Blockers; Strychnine; Substantia Gelatinosa; Tetrodotoxin; TRPV Cation Channels; Tryptophan | 2009 |
Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Pain Threshold; Physical Stimulation; RNA, Messenger; Time Factors; TRPM Cation Channels; Up-Regulation | 2009 |
Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Morphine; Narcotics; Pain Measurement; Pain Threshold; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; TRPV Cation Channels; Water Deprivation | 2009 |
Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.
Topics: Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hindlimb; Hyperalgesia; Male; Oligopeptides; Pain Measurement; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sensory System Agents; Temperature; TRPV Cation Channels | 2009 |
A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.
Topics: Amino Acids; Anilides; Animals; Arachidonic Acids; Capsaicin; Cinnamates; Endocannabinoids; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyunsaturated Alkamides; Propionates; Receptors, Metabotropic Glutamate; Retinal Bipolar Cells; Ruthenium Red; Synaptic Transmission; Transient Receptor Potential Channels; TRPM Cation Channels; TRPV Cation Channels; Xanthenes | 2009 |
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats.
Topics: Animals; Blotting, Western; Capsaicin; Catheterization; Colon; Drinking Behavior; Female; Immunohistochemistry; Macrophages; Mast Cells; Maternal Deprivation; Nerve Growth Factor; Pregnancy; Pyrrolidines; Rats; Rats, Long-Evans; Stress, Psychological; T-Lymphocytes; Transcription, Genetic; TRPV Cation Channels; Urea | 2009 |
TRPM8, a versatile channel in human sperm.
Topics: Acrosome Reaction; Calcium; Capsaicin; Chemotaxis; Fluorescent Antibody Technique, Indirect; Humans; Male; Models, Biological; Progesterone; Pyrazines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sperm Motility; Spermatozoa; TRPM Cation Channels | 2009 |
Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.
Topics: Acrosome Reaction; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Cricetinae; Endocannabinoids; Humans; Infertility, Male; Male; Phospholipase D; Polyunsaturated Alkamides; Progesterone; Receptor, Cannabinoid, CB1; Spermatozoa; TRPV Cation Channels | 2009 |
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Male; Mice; Motor Activity; Neurons; Oleanolic Acid; Opioid Peptides; Pain; Pain Measurement; Physical Stimulation; Protein Kinase C; Psychomotor Performance; Rats; Rats, Wistar; Serotonin; Signal Transduction; TRPV Cation Channels | 2009 |
Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin a.
Topics: Acetylcholine; Animals; Body Weight; Botulinum Toxins, Type A; Capsaicin; Cell Line; Electrophysiology; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Confocal; Motor Neurons; Muscle Strength; Muscle, Skeletal; Nerve Endings; Neuromuscular Agents; Neuromuscular Junction; Neuroprotective Agents; Synapses; TRPV Cation Channels | 2009 |
Endogenous expression of TRPV1 channel in cultured human melanocytes.
Topics: Calcium; Capsaicin; Cells, Cultured; Humans; Immunohistochemistry; Melanins; Melanocytes; Membrane Potentials; Monophenol Monooxygenase; TRPV Cation Channels | 2009 |
AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Hypertension; Imidazoles; Insulin-Like Growth Factor I; Kidney; Losartan; Male; Myocardium; Nifedipine; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; RNA, Messenger; Sensory Receptor Cells; Telmisartan; Tetrazoles; Valine; Valsartan; Vasodilator Agents | 2009 |
Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation.
Topics: Animals; Capsaicin; Cell Line; Cell Respiration; Diterpenes; Encephalitis; Gliosis; Ion Channel Gating; Lanthanum; Membrane Potentials; Mice; Microglia; NADPH Oxidases; Organ Culture Techniques; Oxidative Stress; Reactive Oxygen Species; Respiratory Burst; Ruthenium Red; TRPV Cation Channels | 2009 |
Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol.
Topics: Alcohol Drinking; Animals; Capsaicin; Central Nervous System Depressants; Choice Behavior; Ethanol; Mice; Mice, Inbred C57BL; Mice, Knockout; Postural Balance; Substance Withdrawal Syndrome; Taste; TRPV Cation Channels | 2009 |
Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids.
Topics: Analgesics; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Male; Microinjections; Morpholines; Naphthalenes; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Wistar; Time Factors; TRPV Cation Channels | 2009 |
Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.
Topics: Acetanilides; Action Potentials; Animals; Capsaicin; Formaldehyde; Ganglia, Spinal; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Purines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2009 |
Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
Topics: Alkynes; Animals; Capsaicin; Cystathionine gamma-Lyase; Glycine; Hydrogen Sulfide; Liver; Lung; Male; Mice; Multiple Organ Failure; Neurogenic Inflammation; Peroxidase; Sepsis; Sulfides; Transient Receptor Potential Channels; TRPV Cation Channels | 2010 |
Protective effect of anacardic acids from cashew (Anacardium occidentale) on ethanol-induced gastric damage in mice.
Topics: Anacardic Acids; Anacardium; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Catalase; Ethanol; Gastric Mucosa; KATP Channels; Male; Malondialdehyde; Mice; Nitric Oxide; Prostaglandins; Rats; Rats, Wistar; Stomach Ulcer; Superoxide Dismutase | 2010 |
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.
Topics: Animals; Capsaicin; Clotrimazole; Cold Temperature; Humans; Imidazoles; Ion Channel Gating; Menthol; Mice; Models, Molecular; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Phenotype; Pyrazines; Pyridines; Structure-Activity Relationship; TRPM Cation Channels; Tyrosine | 2009 |
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels | 2010 |
Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats.
Topics: Animals; Auditory Pathways; Behavior, Animal; Biomarkers; Capsaicin; Disease Models, Animal; Male; Membrane Transport Modulators; Neuropsychological Tests; Rats; Rats, Wistar; RNA, Messenger; Salicylates; Spiral Ganglion; Time Factors; Tinnitus; TRPV Cation Channels; Up-Regulation | 2010 |
Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle.
Topics: Acrolein; Action Potentials; Animals; Ankyrins; Calcium Channels; Camphor; Capsaicin; Evoked Potentials; Hair Follicle; In Vitro Techniques; Isothiocyanates; Male; Mechanoreceptors; Menthol; Physical Stimulation; Pyrimidinones; Rats; Rats, Wistar; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpenes; Ethanol; Gastric Mucosa; Glyburide; Indomethacin; Male; Mice; Mucus; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Plant Leaves; Plectranthus; Quinones; Stomach; Stomach Ulcer; Sulfhydryl Compounds; Thiobarbiturates | 2010 |
2-APB and capsazepine-induced Ca2+ influx stimulates clathrin-dependent endocytosis in alveolar epithelial cells.
Topics: Alveolar Epithelial Cells; Animals; Boron Compounds; Calcium; Capsaicin; Cell Line; Cells, Cultured; Clathrin; Endocytosis; Male; Rats; Rats, Sprague-Dawley | 2010 |
Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation.
Topics: Adenosine Triphosphate; Calcium; Capsaicin; Cell Proliferation; Cells, Cultured; Diterpenes; Glycolates; Humans; Immunohistochemistry; Keratinocytes; Skin, Artificial; TRPV Cation Channels | 2010 |
Neuroprotection induced by vitamin E against oxidative stress in hippocampal neurons: involvement of TRPV1 channels.
Topics: alpha-Tocopherol; Animals; Calcium; Capsaicin; Cell Death; Cells, Cultured; Diterpenes; Electric Conductivity; Ferrous Compounds; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels | 2010 |
TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.
Topics: Analysis of Variance; Angiotensin II; Anilides; Animals; Capsaicin; Chelating Agents; Cinnamates; Diuretics, Osmotic; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Piperidines; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Supraoptic Nucleus; TRPV Cation Channels; Vasoconstrictor Agents | 2010 |
The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo.
Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Bone Resorption; Capsaicin; Cell Differentiation; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Female; Macrophages; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Ovariectomy; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; TRPV Cation Channels | 2010 |
Direct activation of transient receptor potential V1 by nickel ions.
Topics: Animals; Capsaicin; Cell Line; Cricetinae; Ganglia, Spinal; Gene Expression Regulation; Humans; Mice; Neurons; Nickel; Rats; Ruthenium Red; Temperature; Trigeminal Ganglion; TRPV Cation Channels | 2010 |
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Carrageenan; Hyperalgesia; Inflammation; Mice; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2010 |
The TRPv1 receptor is a mediator of the exercise pressor reflex in rats.
Topics: Animals; Blood Pressure; Capsaicin; Diterpenes; Heart Rate; Hindlimb; Male; Muscle Contraction; Muscle, Skeletal; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Reflex; Ruthenium Red; TRPV Cation Channels | 2010 |
Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Anti-Allergic Agents; Benzalkonium Compounds; Calcitonin Gene-Related Peptide; Capsaicin; Colon; Hydrogen-Ion Concentration; In Vitro Techniques; Inflammation Mediators; Ketotifen; Male; Mast Cells; Nerve Tissue Proteins; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley; Sodium Channels; Solutions; TRPV Cation Channels | 2009 |
Opposing effects of cannabinoids and vanilloids on evoked quantal release at the frog neuromuscular junction.
Topics: Acetylcholine; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Pyrazoles; Rana catesbeiana; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2010 |
[Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol].
Topics: Animals; Calcium; Calcium-Transporting ATPases; Capsaicin; Carbachol; Cold Temperature; In Vitro Techniques; Intracellular Membranes; Isotonic Solutions; Male; Menthol; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Receptors, Adrenergic; Receptors, Muscarinic; Sarcoplasmic Reticulum; TRPM Cation Channels; Vas Deferens | 2009 |
Role of TRPV1 channels in boar spermatozoa acquisition of fertilizing ability.
Topics: Actins; Animals; Calcium; Capsaicin; Female; Fertilization; Fluorescent Dyes; Male; Membrane Potentials; Sperm Capacitation; Spermatozoa; Swine; TRPV Cation Channels | 2010 |
Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice.
Topics: Acetic Acid; Administration, Intravesical; Animals; Capsaicin; Decerebrate State; Female; Irritants; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Neurons, Afferent; Neurons, Efferent; Pressure; Reflex; Time Factors; TRPV Cation Channels; Urethra; Urinary Bladder; Urination | 2010 |
TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation.
Topics: Acrolein; Analysis of Variance; Arginine; Calcium Channels; Capsaicin; Cyclohexanols; Female; Humans; Immunohistochemistry; Indomethacin; Isothiocyanates; Male; Middle Aged; Nerve Tissue Proteins; Receptors, Cannabinoid; Signal Transduction; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels; Urethra | 2010 |
Functional vanilloid receptor-1 in human submandibular glands.
Topics: Adult; Aged; Aquaporin 5; Calcium; Capsaicin; Cell Line; Cell Membrane; Cytoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Male; Middle Aged; Mucous Membrane; Phosphorylation; Saliva; Salivary Ducts; Serous Membrane; Submandibular Gland; TRPV Cation Channels; Young Adult | 2010 |
Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.
Topics: Adult; Adult Stem Cells; Angiotensin II; Animals; Base Sequence; Calcitonin Gene-Related Peptide; Capsaicin; Cellular Senescence; DNA Primers; Endothelial Cells; Female; Humans; Hypertension; In Vitro Techniques; Indole Alkaloids; Male; Middle Aged; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; TRPV Cation Channels | 2010 |
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.
Topics: Administration, Topical; Animals; Capsaicin; Carbazoles; Dermis; Elasticity; Face; Female; Ganglia, Spinal; Genes; Glucosides; Humans; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pyrroles; RNA, Messenger; Sensory Receptor Cells; Skin; TRPV Cation Channels | 2010 |
Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Bepridil; Biological Transport; Capsaicin; Cryopreservation; Cyproheptadine; Dantrolene; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Estradiol; Hepatocytes; Humans; Isoenzymes; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Rats; Solute Carrier Organic Anion Transporter Family Member 1B3; Species Specificity; Structure-Activity Relationship | 2010 |
1-Nitro-2-phenylethane, the main constituent of the essential oil of Aniba canelilla, elicits a vago-vagal bradycardiac and depressor reflex in normotensive rats.
Topics: Animals; Aorta; Atropine Derivatives; Benzene Derivatives; Bradycardia; Capsaicin; Cryptocarya; Dose-Response Relationship, Drug; Herb-Drug Interactions; Hypotension; In Vitro Techniques; Male; Oils, Volatile; Ondansetron; Phenylephrine; Rats; Rats, Wistar; Reflex; Vagus Nerve; Vasoconstriction | 2010 |
'TRPing' synaptic ribbon function in the rat pineal gland: neuroendocrine regulation involves the capsaicin receptor TRPV1.
Topics: Animals; Bradykinin; Calcium; Capsaicin; Kinesins; Melatonin; Membrane Potentials; Norepinephrine; Pineal Gland; Rats; Rats, Sprague-Dawley; Synapses; TRPV Cation Channels | 2010 |
Existence and distinction of acid-evoked currents in rat astrocytes.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Animals; Animals, Newborn; Astrocytes; Calcium; Capsaicin; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; TRPV Cation Channels | 2010 |
Characterization of in vitro metabolism of capsazepine, a vanilloid transient receptor potential channel antagonist, by liquid chromatography quadrupole ion trap mass spectrometry.
Topics: Animals; Capsaicin; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Mass Spectrometry; Mice; Microsomes, Liver; Rats; TRPV Cation Channels | 2011 |
Emodin down-regulates expression of TRPV1 mRNA and its function in DRG neurons in vitro.
Topics: Analgesics; Animals; Calcium; Capsaicin; Cells, Cultured; Down-Regulation; Emodin; Ganglia, Spinal; Gene Expression; Neurons; Plant Extracts; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rheum; Rhizome; RNA, Messenger; TRPV Cation Channels | 2010 |
Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins.
Topics: Animals; Arginase; Arteriovenous Shunt, Surgical; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Female; Femoral Artery; Femoral Vein; Hemodynamics; Iliac Vein; Infusion Pumps, Implantable; Infusions, Intravenous; Ligation; Matrix Metalloproteinase 2; Mechanotransduction, Cellular; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Sensory System Agents; Sulfonamides; Time Factors; TRPV Cation Channels | 2010 |
Modulation of single-channel properties of TRPV1 by phosphorylation.
Topics: Algorithms; Capsaicin; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Enzyme Activation; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Nerve Growth Factor; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; TRPV Cation Channels | 2010 |
Amphiphile regulation of ion channel function by changes in the bilayer spring constant.
Topics: Algorithms; Capsaicin; Cell Line; Cell Membrane; Genistein; Gramicidin; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating; Ion Channels; Isoflavones; Kinetics; Lipid Bilayers; Membrane Potentials; Membrane Proteins; Octoxynol; Phloretin; Phosphatidylcholines; Protein Conformation | 2010 |
Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; TRPV Cation Channels | 2010 |
TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells.
Topics: Blotting, Western; Calcium; Capsaicin; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fura-2; Humans; Hypertonic Solutions; Interleukin-6; Interleukin-8; Microscopy, Fluorescence; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Stress, Physiological; Sulfonamides; Thiourea; Time Factors; TRPV Cation Channels | 2011 |
Evidence for CGRP re-uptake in rat dura mater encephali.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Capsaicin; Dipeptides; Dura Mater; Male; Peptide Fragments; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells | 2010 |
Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms.
Topics: Animals; Calcium Channel Blockers; Capsaicin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Hydrogen Sulfide; Male; MAP Kinase Signaling System; Nociceptors; Pain, Intractable; Pancreatic Ducts; Phosphorylation; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, PAR-2 | 2010 |
TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina.
Topics: Animals; Axotomy; Capsaicin; Cell Count; Fluoresceins; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Lipid Peroxidation; Neuroglia; Nitric Oxide; Nitrosation; Optic Nerve; Organic Chemicals; Rats; Rats, Wistar; Retinal Ganglion Cells; TRPV Cation Channels | 2010 |
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
Topics: Acute Disease; Animals; Benzamidines; Capsaicin; Ceruletide; Disease Models, Animal; Gene Expression Regulation; Guanidines; Hyperalgesia; Male; Mice; Oligopeptides; Pain; Pancreatitis; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; Spinal Cord; TRPV Cation Channels | 2010 |
TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits.
Topics: Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Capsaicin; Lung; Male; Malondialdehyde; Models, Animal; Neutrophils; Oxidative Stress; Peroxidase; Rabbits; Reperfusion Injury; TRPV Cation Channels | 2012 |
dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant.
Topics: Anti-Inflammatory Agents; Asthma; Bronchi; Capsaicin; Cell Survival; Cells, Cultured; Cytokines; Dexamethasone; Epithelial Cells; Humans; I-kappa B Proteins; NF-KappaB Inhibitor alpha; RNA, Double-Stranded; RNA, Messenger; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha | 2011 |
Bring on the heat: transient receptor potential vanilloid type-1 (TRPV-1) channels as a sensory link for local thermal hyperaemia.
Topics: Anesthetics, Local; Capsaicin; Hot Temperature; Humans; Hyperemia; Lidocaine; Lidocaine, Prilocaine Drug Combination; Nitric Oxide; Prilocaine; Regional Blood Flow; Sensory Receptor Cells; Skin; TRPV Cation Channels | 2010 |
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
Topics: Acetanilides; Acrolein; Animals; Animals, Newborn; Ankyrins; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Garlic; Laser-Doppler Flowmetry; Meningeal Arteries; Mustard Plant; Neurons; Peptide Fragments; Plant Oils; Purines; Rats; Sensory System Agents; Substance P; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; Vasodilation | 2011 |
The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.
Topics: Animals; Calcium; Capsaicin; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Indoles; KCNQ Potassium Channels; Neurons; Nociceptors; Pyridines; Rats; Rats, Wistar; TRPV Cation Channels | 2010 |
Diabetic rats show reduced cardiac-somatic reflex evoked by intrapericardial capsaicin.
Topics: Animals; Biomechanical Phenomena; Blood Glucose; Body Weight; Capsaicin; Diabetes Mellitus; Electric Stimulation; Electromyography; Heart; Injections; Male; Pericardium; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Temperature; TRPV Cation Channels | 2011 |
Atomic force microscopy of microvillous cell surface dynamics at fixed and living alveolar type II cells.
Topics: Alveolar Epithelial Cells; Animals; Boron Compounds; Calcium; Capsaicin; Cell Membrane; Cells, Cultured; Cytoskeletal Proteins; Endocytosis; Glutaral; Imaging, Three-Dimensional; Lung; Male; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Scanning; Microvilli; Rats; Rats, Sprague-Dawley | 2011 |
Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Culture Techniques; Drug Interactions; Endocannabinoids; Glycerides; Hippocampus; Monoacylglycerol Lipases; Nerve Degeneration; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2011 |
Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.
Topics: Animals; Behavior, Animal; Capsaicin; Endothelin-1; Enzyme Inhibitors; Histamine; Irritants; Male; Mice; Mice, Inbred C57BL; Pruritus; Ruthenium Red; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2011 |
Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.
Topics: Animals; Bacterial Load; Capsaicin; Cecum; Cytokines; Disease Models, Animal; Diterpenes; Down-Regulation; Female; Flow Cytometry; Gene Expression; Ligation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Peritoneal Lavage; Peritoneum; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Survival Analysis; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2011 |
TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
Topics: Acrosome Reaction; Animals; Capsaicin; Humans; Ion Channel Gating; Male; Menthol; Mice; Mice, Knockout; Pyrazines; Pyridines; Pyrimidinones; Spermatozoa; Temperature; Testis; TRPM Cation Channels | 2011 |
TRPV1 receptors modulate retinal development.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Capsaicin; Caspase 3; Cell Proliferation; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Rats; Retina; TRPV Cation Channels | 2011 |
Human dental pulp fibroblasts express the "cold-sensing" transient receptor potential channels TRPA1 and TRPM8.
Topics: Acetanilides; Acrolein; Adult; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Cold Temperature; Cytophotometry; Dental Pulp; Fibroblasts; Humans; Immunohistochemistry; Membrane Proteins; Menthol; Nerve Tissue Proteins; Nociceptors; Physical Stimulation; Purines; Reverse Transcriptase Polymerase Chain Reaction; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; Young Adult | 2011 |
The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.
Topics: Capsaicin; Carcinoma; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-6; Male; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Signal Transduction; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2011 |
Capsaicinoids regulate airway anion transporters through Rho kinase- and cyclic AMP-dependent mechanisms.
Topics: Adenylyl Cyclases; Anion Transport Proteins; Antiporters; Capsaicin; Cell Line; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Ion Transport; Membrane Potentials; Membrane Transport Proteins; Patch-Clamp Techniques; Protein Kinase Inhibitors; Respiratory Mucosa; rho-Associated Kinases; SLC4A Proteins; Sodium-Bicarbonate Symporters; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2011 |
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.
Topics: Animals; Antineoplastic Agents; Atropine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Cisplatin; Cricetinae; Cricetulus; Dipeptides; Disease Models, Animal; Drug Interactions; Ganglia, Spinal; Gene Expression Regulation; Guinea Pigs; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Piperazines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensory Receptor Cells; Spectrometry, Mass, Electrospray Ionization; Superoxides; Tissue Culture Techniques; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Body Temperature Regulation; Brain; Camphanes; Capsaicin; Disease Models, Animal; Diterpenes; Endocannabinoids; Female; Hypothermia; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Lipopolysaccharides; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sulfonamides; Time Factors; TRPV Cation Channels | 2011 |
Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Transfection; TRPV Cation Channels | 2011 |
[Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats].
Topics: Animals; Apoptosis; Capsaicin; Cardiotonic Agents; Male; Myocardial Reperfusion Injury; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley | 2011 |
Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P.
Topics: Animals; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Diabetes Mellitus, Experimental; Heart; In Vitro Techniques; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Myocardium; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P; TRPV Cation Channels; Ventricular Function | 2011 |
Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
Topics: Animals; Capsaicin; Cholestasis; Disease Models, Animal; Indoles; Inflammation Mediators; Leukotriene B4; Ligation; Lipoxygenase Inhibitors; Male; Models, Biological; Pancreatitis; Peroxidase; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2011 |
Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.
Topics: Acetanilides; Acrolein; Animals; Capsaicin; Cold Temperature; Hot Temperature; In Vitro Techniques; Lung; Male; Menthol; Purines; Rats; Rats, Sprague-Dawley; Respiratory System; Sensory System Agents; TRPM Cation Channels | 2011 |
Mechanisms underlying the protective effect of eugenol in rats with acute doxorubicin cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Calcium Signaling; Capsaicin; Cardiotonic Agents; Cardiotoxins; Caspase 3; Doxorubicin; Eugenol; Heart; Heart Failure; Lipid Peroxidation; Male; Myocardium; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2011 |
Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine.
Topics: Anticarcinogenic Agents; Aromatase; Capsaicin; Capsicum; Cell Line; Humans; Inhibitory Concentration 50; NF-kappa B; Plant Extracts; Transfection; Tumor Necrosis Factor-alpha | 2011 |
Opposite effect of capsaicin and capsazepine on behavioral thermoregulation in insects.
Topics: Animals; Behavior, Animal; Body Temperature Regulation; Capsaicin; Dose-Response Relationship, Drug; Larva; Sensory System Agents; Tenebrio; Time Factors; TRPV Cation Channels | 2011 |
TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Excitatory Amino Acid Agents; Glutamates; Neurons; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission; TRPV Cation Channels | 2011 |
Characterization of capsaicin induced responses in mice vas deferens: evidence of CGRP uptake.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mice; Protein Transport; TRPV Cation Channels; Vas Deferens | 2011 |
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases | 2011 |
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Capsaicin; Depression; Dopamine; Endocannabinoids; Hindlimb Suspension; Ligands; Male; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming; TRPV Cation Channels | 2011 |
Osmosensitivity of transient receptor potential vanilloid 1 is synergistically enhanced by distinct activating stimuli such as temperature and protons.
Topics: Animals; Aquaporins; Calcium; Capsaicin; HEK293 Cells; Humans; Mercury Compounds; Mice; Mice, Knockout; Protons; Ruthenium Red; Temperature; TRPV Cation Channels; Water-Electrolyte Balance | 2011 |
Capsaicin induces reflex scratching in inflamed skin.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Freund's Adjuvant; Inflammation; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Pain; Pruritus; Receptors, Opioid, mu; Reflex; Sensory System Agents; Skin; Time Factors; TRPV Cation Channels | 2011 |
Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.
Topics: Animals; Capsaicin; Cell Nucleus; Chemokines; Cytokines; Extracellular Signal-Regulated MAP Kinases; Hydrogen Sulfide; Inflammation; Male; Mice; NF-kappa B; Phosphorylation; Sepsis; Substance P; TRPV Cation Channels | 2011 |
Opposing roles for cannabinoid receptor type-1 (CB₁) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Topics: Anilides; Animals; Arachidonic Acids; Capsaicin; Cinnamates; Drug Interactions; Electric Stimulation; Male; Microinjections; Panic; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2012 |
Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Topics: Animals; Body Temperature; Calcium; Calcium Radioisotopes; Capsaicin; Dihydropyridines; Electrophysiological Phenomena; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Phosphorylation; Protons; Rats; Serine; TRPV Cation Channels | 2012 |
Transient receptor potential vanilloid 1 channels modulate the anxiolytic effect of diazepam.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Capsaicin; Diazepam; Dose-Response Relationship, Drug; Injections, Intraventricular; Interpersonal Relations; Male; Mice; Motor Activity; TRPV Cation Channels | 2011 |
Antagonism of the TRPv1 receptor partially corrects muscle metaboreflex overactivity in spontaneously hypertensive rats.
Topics: Animals; Baroreflex; Blood Pressure; Capsaicin; Electric Stimulation; Hindlimb; Hypertension; Ischemia; Kidney; Male; Muscle Contraction; Muscle, Skeletal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sciatic Nerve; Sympathetic Nervous System; TRPV Cation Channels | 2011 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones | 2012 |
Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response.
Topics: Animals; Capsaicin; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Ion Channel Gating; Mice; Sensory Receptor Cells; Sensory System Agents; Thermosensing; TRPV Cation Channels | 2012 |
Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia.
Topics: Acetylcysteine; Analysis of Variance; Anilides; Animals; Antioxidants; Autoradiography; Bradykinin; Bradykinin B1 Receptor Antagonists; Capsaicin; Cinnamates; Dose-Response Relationship, Drug; Gene Expression Regulation; Iodine Isotopes; Male; Microglia; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; RNA, Messenger; Sensory System Agents; Spinal Cord; Superoxides; Tetrahydroisoquinolines; Time Factors; TRPV Cation Channels | 2012 |
Role of TRPV1 in consolidation of fear memories depends on the averseness of the conditioning procedure.
Topics: Animals; Avoidance Learning; Capsaicin; Conditioning, Psychological; Fear; Hippocampus; Male; Memory; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels | 2012 |
Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Capsaicin; Cimetidine; Ethanol; Galactose; Galectins; Gastric Mucosa; Glutathione; Glyburide; Indomethacin; Male; Malondialdehyde; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phytotherapy; Plant Extracts; Stomach Ulcer | 2012 |
Acute myocardial ischemia enhances the vanilloid TRPV1 and serotonin 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats.
Topics: Acute Disease; Animals; Capsaicin; Male; Myocardial Ischemia; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Reflex; TRPV Cation Channels; Vagus Nerve Stimulation | 2011 |
Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension.
Topics: Amidohydrolases; Animals; Aorta; Benzamides; Biomimetic Materials; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Endocannabinoids; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Oleic Acids; Rats; Receptor, Cannabinoid, CB1; TRPV Cation Channels; Vasodilator Agents | 2012 |
Characterization of a novel splice variant of δ ENaC subunit in human lungs.
Topics: Alveolar Epithelial Cells; Amiloride; Amino Acid Sequence; Animals; Biological Transport; Capsaicin; Cloning, Molecular; Electric Conductivity; Epithelial Sodium Channels; Exocytosis; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Lung; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Respiratory Mucosa; RNA Splicing; Sodium; Xenopus | 2012 |
Vasorelaxation to capsaicin and its effects on calcium influx in arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Abdominal; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Swine; TRPV Cation Channels; Vasodilation | 2012 |
A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Capsaicin; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Fluoxetine; Injections, Intraventricular; Male; Mice; Serotonin; Swimming; TRPV Cation Channels | 2012 |
Capacity of capsazepinoids to relax human small airways and inhibit TLR3-induced TSLP and IFNβ production in diseased bronchial epithelial cells.
Topics: Adult; Aged; Asthma; Base Sequence; Bronchi; Bronchodilator Agents; Capsaicin; Cells, Cultured; Cytokines; Epithelial Cells; Female; Humans; In Vitro Techniques; Interferon-beta; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; RNA, Messenger; Thymic Stromal Lymphopoietin; Toll-Like Receptor 3; Young Adult | 2012 |
Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells.
Topics: Airway Obstruction; Bronchi; Calcium; Capsaicin; Cell Line; Citric Acid; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Humans; In Vitro Techniques; Mucin 5AC; Patch-Clamp Techniques; TRPV Cation Channels | 2012 |
G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
Topics: Amino Acids; Animals; Capsaicin; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Humans; Light; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Protein Multimerization; Receptors, Metabotropic Glutamate; Retinal Bipolar Cells; TRPM Cation Channels; Xanthenes | 2012 |
Transient receptor potential vanilloid-1 regulates osteoprotegerin/RANKL homeostasis in human periodontal ligament cells.
Topics: 3T3 Cells; Animals; Bone Remodeling; Calcium; Capsaicin; Cell Culture Techniques; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Estrenes; Homeostasis; Humans; Mice; Osteoblasts; Osteoprotegerin; Periodontal Ligament; Phosphodiesterase Inhibitors; Pyrrolidinones; RANK Ligand; TRPV Cation Channels; Type C Phospholipases | 2013 |
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anilides; Animals; Capsaicin; Cinnamates; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Enzyme Inhibitors; Large-Conductance Calcium-Activated Potassium Channels; Male; Mice; Mice, Inbred C57BL; Microvessels; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptides; TRPV Cation Channels; Vasoconstrictor Agents; Vasodilation | 2012 |
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation | 2012 |
N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety Disorders; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels | 2012 |
TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Cannabinoid Receptor Antagonists; Capsaicin; Cyclic AMP; Diterpenes; Endocannabinoids; Glycerides; Hydrogen-Ion Concentration; Odontoblasts; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Sodium-Calcium Exchanger; Thiourea; TRPV Cation Channels | 2012 |
Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.
Topics: Animals; Calcium; Capsaicin; Cell Movement; Cytoskeleton; Morpholines; Myocytes, Smooth Muscle; Phorbol Esters; Pulmonary Artery; Pyrroles; Rats; RNA, Messenger; TRPV Cation Channels | 2012 |
Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors.
Topics: Air Pollutants; Bronchi; Calcium; Capsaicin; Cell Line, Transformed; Chelating Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Environmental Exposure; Epithelial Cells; Exocytosis; Humans; Isoquinolines; Microscopy, Confocal; Mucin 5AC; Mucins; Particulate Matter; Protein Kinase Inhibitors; Sulfonamides; TRPV Cation Channels | 2012 |
Role of KATP channels and TRPV1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake mice.
Topics: Animals; Capsaicin; Gastric Emptying; Glyburide; Hydrogen Sulfide; KATP Channels; Male; Mice; Muscle Relaxation; Potassium Channel Blockers; Pylorus; TRPV Cation Channels | 2012 |
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Capsaicin; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Colorectal Neoplasms; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; TRPV Cation Channels; Up-Regulation | 2012 |
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Formaldehyde; Hyperalgesia; Indoles; Male; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2012 |
Comparison of the effects of pelargonic acid vanillylamide and capsaicin on human vanilloid receptors.
Topics: Animals; Benzylamines; Capsaicin; Fatty Acids; HEK293 Cells; Humans; TRPV Cation Channels | 2013 |
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
Topics: Animals; Benzoxazines; Binding Sites; Bone Resorption; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Differentiation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Glycosylation; Humans; Macrophages; Matrix Metalloproteinase 9; Mice; Microglia; Monocytes; Morpholines; Naphthalenes; Osteoclasts; Phosphorylation; Pneumonia; PPAR gamma; Receptors, Cannabinoid; rho GTP-Binding Proteins; Signal Transduction; TRPV Cation Channels | 2012 |
Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Male; Maze Learning; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; TRPV Cation Channels | 2013 |
The monoterpene (-)-carvone: a novel agonist of TRPV1 channels.
Topics: Animals; Calcium Signaling; Capsaicin; Cell Survival; Cyclohexane Monoterpenes; HEK293 Cells; Humans; Monoterpenes; Neurons; Rats; Rats, Wistar; TRPV Cation Channels | 2013 |
Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland.
Topics: Animals; Blotting, Western; Capsaicin; Cell Line; Flavonoids; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Occludin; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; Submandibular Gland; Tight Junctions; TRPV Cation Channels | 2013 |
Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Capsaicin; Cells, Cultured; Chlorides; Colforsin; Epinephrine; Epithelial Cells; Formaldehyde; Imines; Male; Nerve Endings; ortho-Aminobenzoates; Quinuclidines; Rats; Respiratory Mucosa; Substance P; Trachea; TRPV Cation Channels | 2013 |
Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats.
Topics: Acetanilides; Acetylcysteine; Animals; Antioxidants; Apnea; Calcium Channels; Capsaicin; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Indomethacin; Laryngeal Nerves; Larynx; Neurons, Afferent; Purines; Rats; Reactive Oxygen Species; Smoking; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2013 |
Role of TRPV1 and P2X receptors in the activation of lung vagal C-fiber afferents by inhaled cigarette smoke in rats.
Topics: Animals; Capsaicin; Cholinergic Fibers; Humans; Hydroxyl Radical; Pyridoxal Phosphate; Rats; Reactive Oxygen Species; Receptors, Nicotinic; Receptors, Purinergic P2X; Smoke; Smoking; Thiourea; TRPV Cation Channels | 2013 |
Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats.
Topics: Acetanilides; Acyclic Monoterpenes; Animals; Aorta; Atropine Derivatives; Blood Pressure; Bradycardia; Capsaicin; Hypotension; In Vitro Techniques; Lauraceae; Male; Monoterpenes; Oils, Volatile; Ondansetron; Phenylephrine; Plant Oils; Purines; Rats; Rats, Wistar; Reflex | 2014 |
Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling.
Topics: Acetanilides; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Glyburide; Guanylate Cyclase; Hydrogen Sulfide; Indomethacin; KATP Channels; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Phenylephrine; Pituitary Adenylate Cyclase-Activating Polypeptide; Purines; Pyrazoles; Sensory Receptor Cells; Swine; Synaptic Transmission; Urinary Bladder | 2013 |
The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells.
Topics: Capsaicin; Cell Line; Cell Nucleus; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Response; HSP70 Heat-Shock Proteins; Humans; Protein Binding; Protein Transport; Transcription Factors; TRPV Cation Channels | 2013 |
Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dogs; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; MCF-7 Cells; TRPV Cation Channels | 2015 |
Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
Topics: Animals; Calcium; Capsaicin; Male; Mice; Muscle, Skeletal; Protein Transport; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; TRPV Cation Channels | 2013 |
Neuroprotection induced by N-acetylcysteine against cytosolic glutathione depletion-induced Ca2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Calcium Signaling; Capsaicin; Caspase 3; Caspase 9; Cell Survival; Cells, Cultured; Cytosol; Drug Interactions; Ganglia, Spinal; Glutathione; Lipid Peroxidation; Male; Membrane Potentials; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; TRPV Cation Channels | 2013 |
Detection of mouse cough based on sound monitoring and respiratory airflow waveforms.
Topics: Animals; Capsaicin; Codeine; Cough; Female; Mice; Mice, Inbred BALB C; Plethysmography, Whole Body; Pulmonary Ventilation; Respiratory Sounds; Sodium Chloride | 2013 |
Capsaicin regulates the NF-κB pathway in salivary gland inflammation.
Topics: Animals; Anti-Inflammatory Agents; Capsaicin; Cells, Cultured; Cytokines; Epithelial Cells; Escherichia coli; I-kappa B Proteins; Inflammation Mediators; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Poly I-C; Salivary Ducts; Sialadenitis; Submandibular Gland; Time Factors; Toll-Like Receptors; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2013 |
TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.
Topics: Amiloride; Anilides; Animals; Capsaicin; Chorda Tympani Nerve; Cinnamates; Diterpenes; Mice; Mice, Knockout; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sodium Chloride; Taste; TRPM Cation Channels; TRPV Cation Channels | 2013 |
Capsicum annuum enhances L-lactate production by Lactobacillus acidophilus: implication in curd formation.
Topics: Capsaicin; Capsicum; Cultured Milk Products; Hydrogen-Ion Concentration; Lactic Acid; Lactobacillus acidophilus; Temperature | 2013 |
Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice.
Topics: Acetanilides; Animals; Asthma; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Immunoglobulin E; Immunohistochemistry; Interleukin-1beta; Interleukin-4; Interleukin-6; Lung; Male; Mice; Mice, Inbred BALB C; Neuropeptides; Ovalbumin; Purines; Substance P; Transient Receptor Potential Channels | 2013 |
Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Male; Maze Learning; Mice; Microinjections; Periaqueductal Gray; TRPV Cation Channels | 2013 |
Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Conditioning, Operant; Facial Nerve; Facial Pain; Hyperalgesia; Male; Menthol; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trigeminal Nerve; Trigeminal Nerve Injuries; TRPM Cation Channels | 2013 |
Leptin modulates enteric neurotransmission in the rat proximal colon: an in vitro study.
Topics: Acetylcholine; Animals; Capsaicin; Cholinergic Agonists; Colon; Enteric Nervous System; Hexamethonium; Humans; In Vitro Techniques; Leptin; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Synaptic Transmission | 2013 |
Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction.
Topics: Animals; Arachidonic Acids; Benzoates; Capsaicin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endocannabinoids; Glycerides; Imidazoles; Lizards; Miniature Postsynaptic Potentials; Muscarine; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Schwann Cells; Sulfonamides; Thiophenes; Xanthones | 2013 |
Optical control of TRPV1 channels.
Topics: Azo Compounds; Capsaicin; Crystallography, X-Ray; Euphorbia; Isomerism; Molecular Conformation; TRPV Cation Channels | 2013 |
Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α.
Topics: Animals; Atherosclerosis; Blotting, Western; Calcium; Capsaicin; Cells, Cultured; Chromatin Immunoprecipitation; Inflammation; Lipoproteins, LDL; Liver X Receptors; Macrophages; Mice; Orphan Nuclear Receptors; RNA, Small Interfering; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2013 |
Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs.
Topics: Animals; Capsaicin; Colon; Constipation; Dogs; Drug Evaluation, Preclinical; Gastrointestinal Motility; Herbal Medicine; Infusions, Parenteral; Japan; Medicine, East Asian Traditional; Panax; Plant Extracts; Plants, Medicinal; Stomach; TRPV Cation Channels; Zanthoxylum; Zingiberaceae | 2013 |
Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia.
Topics: Acetanilides; Acrolein; Animals; Calcium; Capsaicin; Molecular Imaging; Primary Cell Culture; Purines; Rats; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Vestibular Nerve | 2013 |
Effect of TRPV1 channel on the proliferation and apoptosis in asthmatic rat airway smooth muscle cells.
Topics: Airway Remodeling; Animals; Apoptosis; Asthma; Calcium; Capsaicin; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hyperplasia; Male; Myocytes, Smooth Muscle; Ovalbumin; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Respiratory System; TRPV Cation Channels | 2013 |
Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Capsaicin; Conditioning, Psychological; Electroshock; Fear; Heart Rate; Male; Microinjections; Prefrontal Cortex; Rats; Rats, Wistar; TRPV Cation Channels | 2014 |
Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway.
Topics: Capsaicin; Cell Line, Tumor; Cell Survival; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Sensory System Agents; Serotonin; Signal Transduction; TRPV Cation Channels | 2013 |
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
Topics: Action Potentials; Animals; Calcium; Capsaicin; Cells, Cultured; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Isothiocyanates; Mice; Mice, Inbred C57BL; Sensory Receptor Cells; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2014 |
Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels.
Topics: Analgesics; Capsaicin; Cyclic Nucleotide-Gated Cation Channels; HEK293 Cells; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Muscle Proteins; Potassium Channels | 2013 |
TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Capsaicin; Convulsants; Disease Models, Animal; Epilepsy; Evoked Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; TRPV Cation Channels | 2013 |
Activation of transient receptor potential ankyrin 1 by eugenol.
Topics: Acetanilides; Analgesics; Animals; Calcium; Calcium Channels; Capsaicin; Eugenol; HEK293 Cells; Humans; Isothiocyanates; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Purines; Rats; Rats, Sprague-Dawley; Sensory System Agents; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels | 2014 |
[6]-shogaol induces Ca²⁺ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells.
Topics: Animals; Calcium Signaling; Capsaicin; Catechols; Cell Line, Tumor; Clone Cells; Dose-Response Relationship, Drug; Glucose; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Rats; TRPV Cation Channels | 2014 |
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociception; Pain; Protons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; TRPV Cation Channels | 2014 |
Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Interpersonal Relations; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Rimonabant; Schizophrenia; Schizophrenic Psychology; TRPV Cation Channels | 2014 |
The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Central Nervous System Agents; Electric Stimulation; Formaldehyde; Freund's Adjuvant; Long-Term Potentiation; Male; Microelectrodes; Nociception; Posterior Horn Cells; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2014 |
Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats.
Topics: Animals; Apoptosis; Calcium; Capsaicin; Caspase 3; Electromagnetic Radiation; Epilepsy; Ganglia, Spinal; Hippocampus; Male; Neurons; Oxidative Stress; Rats; TRPV Cation Channels | 2014 |
Hypoxic preconditioning protects rat hearts against ischemia-reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Caffeic Acids; Capsaicin; Flavanones; Hypoxia; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Male; Myocardial Reperfusion Injury; Myocardium; Protein Kinase C; Protein Transport; Rats, Wistar; Sarcolemma; Signal Transduction; Time Factors; TRPV Cation Channels | 2014 |
Inhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gating.
Topics: 4-Nitrophenylphosphatase; Animals; Biological Transport; Capsaicin; Catalytic Domain; Cell Membrane; Endopeptidase K; Enzyme Inhibitors; Hydrogen-Ion Concentration; Hydrolysis; Intracellular Space; Ion Channel Gating; Isoxazoles; Myocytes, Cardiac; Potassium; Proteolysis; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Temperature; Trypsin; Vanadates | 2014 |
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels | 2014 |
Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Capsaicin; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; Hot Temperature; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; TRPV Cation Channels | 2014 |
QSAR and docking studies on capsazepine derivatives for immunomodulatory and anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Capsaicin; Cell Survival; Cytokines; Drug Evaluation, Preclinical; Female; Immunologic Factors; Macrophages; Mice; Molecular Docking Simulation; Protein Conformation; Quantitative Structure-Activity Relationship; Risk Assessment; Tumor Necrosis Factor-alpha | 2014 |
Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Diabetic Neuropathies; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression Profiling; Gene Expression Regulation; Hyperalgesia; Image Processing, Computer-Assisted; Immunohistochemistry; Rats; Real-Time Polymerase Chain Reaction; Ruthenium Red; Spinal Cord; Streptozocin; Time Factors; TRPV Cation Channels | 2014 |
The ethanol-induced stimulation of rat duodenal mucosal bicarbonate secretion in vivo is critically dependent on luminal Cl-.
Topics: Animals; Anion Transport Proteins; Antiporters; Bicarbonates; Body Fluids; Capsaicin; Chlorine; Cystic Fibrosis Transmembrane Conductance Regulator; Duodenum; Ethanol; Gastric Acid; Hexamethonium; Hydrochloric Acid; Intestinal Mucosa; Male; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfate Transporters | 2014 |
Capsaicin induces "brite" phenotype in differentiating 3T3-L1 preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipocytes, Brown; Adipogenesis; Adipokines; Animals; Biomarkers; Body Weight; Capsaicin; Cell Differentiation; Diet, High-Fat; Gene Expression Regulation; Lipid Metabolism; Mice; Motor Activity; Pain Threshold; Phenotype; PPAR gamma; TRPV Cation Channels | 2014 |
Protons modulate perivascular axo-axonal neurotransmission in the rat mesenteric artery.
Topics: Acetylcholine; Adrenergic Neurons; Animals; Atropine; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Cholinergic Agonists; Guanethidine; Hydrogen-Ion Concentration; Mecamylamine; Mesenteric Arteries; Muscarinic Antagonists; Nicotinic Antagonists; Protons; Rats; Ruthenium Red; Sympatholytics; Synaptic Transmission; Vasoconstriction; Vasodilation | 2014 |
Blocking TRPV1 in nucleus accumbens inhibits persistent morphine conditioned place preference expression in rats.
Topics: Animals; Blotting, Western; Capsaicin; Craving; Dose-Response Relationship, Drug; Male; Microscopy, Immunoelectron; Morphine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Spatial Behavior; TRPV Cation Channels | 2014 |
Effect of TRPV1 channel on proliferation and apoptosis of airway smooth muscle cells of rats.
Topics: Animals; Antipruritics; Apoptosis; Bronchi; Calcium Signaling; Capsaicin; Cell Proliferation; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2014 |
External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1.
Topics: Anesthetics, Local; Animals; Capsaicin; Cranial Nerves; Excitatory Postsynaptic Potentials; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Reaction Time; TRPV Cation Channels | 2014 |
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent.
Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Benzenesulfonates; Capsaicin; Colitis; Colon; Disease Models, Animal; Endocannabinoids; Ethanolamines; Intestinal Absorption; Male; Mice, Inbred ICR; Oleic Acids; Palmitic Acids; Peroxidase; PPAR alpha; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; RNA, Messenger; TRPV Cation Channels | 2015 |
TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium berghei ANKA.
Topics: Animals; Capsaicin; Flow Cytometry; Interferon-gamma; Interleukin-10; Interleukin-17; Interleukin-4; Interleukin-6; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Plasmodium berghei; TRPV Cation Channels | 2014 |
Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay.
Topics: Acetophenones; Acetylcysteine; Animals; beta-Cyclodextrins; Calcium; Calcium Signaling; Capsaicin; Cholesterol; Cyclosporine; Exocytosis; Neuromuscular Junction; Okadaic Acid; Ranidae; Reactive Oxygen Species; Ruthenium Red; Synaptic Membranes; TRPV Cation Channels | 2014 |
Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury.
Topics: Animals; Capsaicin; Eicosanoids; Hydroxyeicosatetraenoic Acids; Kidney; Mice; Mice, Inbred C57BL; Reperfusion Injury; TRPV Cation Channels | 2014 |
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Pyridines; Rats; Sulfones; Time Factors; TRPV Cation Channels | 2014 |
Capsaicin modulates acetylcholine release at the myoneural junction.
Topics: Acetylcholine; Animals; Capsaicin; Exocytosis; Mice; Mice, Inbred C57BL; Neuromuscular Junction; Phrenic Nerve; TRPV Cation Channels; Vagus Nerve Stimulation | 2014 |
Carvacrol presynaptically enhances spontaneous excitatory transmission and produces outward current in adult rat spinal substantia gelatinosa neurons.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cymenes; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Monoterpenes; Neurons; Neurotransmitter Agents; Nociception; Patch-Clamp Techniques; Permeability; Potassium; Potassium Channel Blockers; Purines; Rats, Sprague-Dawley; Substantia Gelatinosa; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2014 |
Full-length transient receptor potential vanilloid 1 channels mediate calcium signals and possibly contribute to osmoreception in vasopressin neurones in the rat supraoptic nucleus.
Topics: Action Potentials; Animals; Calcium Signaling; Capsaicin; Cells, Cultured; HEK293 Cells; Humans; Male; Mannitol; Neurons; Osmolar Concentration; Oxytocin; Pyrazines; Pyridines; Rats; Rats, Transgenic; Rats, Wistar; Supraoptic Nucleus; Temperature; TRPV Cation Channels | 2015 |
Involvement of TRPV1 channels in the periaqueductal grey on the modulation of innate fear responses.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Capsaicin; Cats; Fear; Male; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; TRPV Cation Channels | 2015 |
Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase.
Topics: AMP-Activated Protein Kinases; Anilides; Animals; Calcium; Capsaicin; Catechin; Cell Movement; Cell Proliferation; Cell Survival; Cinnamates; Endothelial Cells; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Signal Transduction; Tea; TRPV Cation Channels | 2015 |
The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Sensory System Agents; Touch; TRPV Cation Channels | 2015 |
Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Bone and Bones; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Dopamine Agonists; Drug Discovery; Female; Glutamic Acid; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Pain; Signal Transduction; Small Molecule Libraries | 2015 |
Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro.
Topics: Capsaicin; Diuretics; Epithelial Cells; Epithelial Sodium Channels; Evans Blue; Gene Knockdown Techniques; Humans; Primary Cell Culture; Pulmonary Alveoli; Pyrimidinones; Respiratory Mucosa; Sodium | 2015 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
Involvement of apoptosis and calcium accumulation through TRPV1 channels in neurobiology of epilepsy.
Topics: Animals; Apoptosis; Calcium; Capsaicin; Diterpenes; Epilepsy; Ganglia, Spinal; Hippocampus; Male; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; TRPV Cation Channels | 2015 |
Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-carvone and (+)-carvone which activate different types of TRP channel.
Topics: Acetanilides; Animals; Capsaicin; Cyclohexane Monoterpenes; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Monoterpenes; Neurons; Patch-Clamp Techniques; Purines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substantia Gelatinosa; Synaptic Transmission; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2015 |
Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs.
Topics: Acetanilides; Anastomosis, Surgical; Animals; Atropine; Capsaicin; Colon; Defecation; Denervation; Dogs; Enteric Nervous System; Ganglionic Blockers; Gastrointestinal Motility; Hexamethonium; Ileum; Isothiocyanates; Muscarinic Antagonists; Ondansetron; Purines; Serotonin Antagonists; Transient Receptor Potential Channels | 2015 |
[6]-gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1.
Topics: Animals; Bumetanide; Capsaicin; Catechols; Colon; Enzyme Inhibitors; Fatty Alcohols; Ileum; Male; Membrane Potentials; Ouabain; Rats; Rats, Sprague-Dawley; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Exchanging ATPase; TRPV Cation Channels | 2014 |
Impaired capsaicin-induced relaxation in diabetic mesenteric arteries.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Peptide Fragments; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Hypericum perforatum Attenuates Spinal Cord Injury-Induced Oxidative Stress and Apoptosis in the Dorsal Root Ganglion of Rats: Involvement of TRPM2 and TRPV1 Channels.
Topics: Animals; Apoptosis; Calcium; Capsaicin; Caspases; Cell Survival; Ganglia, Spinal; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Hypericum; Ion Channel Gating; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Spinal Cord Injuries; TRPM Cation Channels; TRPV Cation Channels | 2016 |
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats.
Topics: Animals; Blotting, Western; Capsaicin; Cyclooxygenase 2; Estradiol; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Nerve Growth Factor; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Temporomandibular Joint; Temporomandibular Joint Disorders; Transcriptional Activation; TRPV Cation Channels; Up-Regulation | 2015 |
Role of TRPV1 channels of the dorsal periaqueductal gray in the modulation of nociception and open elevated plus maze-induced antinociception in mice.
Topics: Animals; Anxiety; Capsaicin; Fear; Male; Maze Learning; Mice; Nociception; Pain; Pain Measurement; Periaqueductal Gray; TRPV Cation Channels | 2015 |
The molecular pathway of ATP-sensitive potassium channel in endothelial cells for mediating arteriole relaxation.
Topics: Allyl Compounds; Anilides; Animals; Arterioles; Calcium; Capsaicin; Cells, Cultured; Cinnamates; Down-Regulation; Endothelial Cells; KATP Channels; Mesenteric Arteries; Nitric Oxide; Propylamines; Rats; RNA, Small Interfering; TRPV Cation Channels; Vasodilation | 2015 |
Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.
Topics: Alkaloids; Analgesics; Animals; Calcium; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Evodia; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Male; Medicine, Chinese Traditional; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Social stress in mice induces urinary bladder overactivity and increases TRPV1 channel-dependent afferent nerve activity.
Topics: Aggression; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Social Environment; Stress, Psychological; TRPV Cation Channels; Urethra; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2015 |
Thermosensation and the TRPV channel in Rhodnius prolixus.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Capsaicin; Chagas Disease; Conditioning, Operant; Feeding Behavior; Gene Expression; Hot Temperature; Insect Vectors; Molecular Sequence Data; Rhodnius; Spatial Learning; Temperature; Thermosensing; TRPV Cation Channels | 2015 |
Alterations in CA1 pyramidal neuronal intrinsic excitability mediated by Ih channel currents in a rat model of amyloid beta pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; CA1 Region, Hippocampal; Capsaicin; Disease Models, Animal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Male; Memory Disorders; Nerve Net; Neurons; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels | 2015 |
Action of thymol on spontaneous excitatory transmission in adult rat spinal substantia gelatinosa neurons.
Topics: Acetanilides; Animals; Capsaicin; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neurons; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Sodium Channel Blockers; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; Thymol; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels | 2015 |
Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats.
Topics: Animals; Baroreflex; Capsaicin; Heart; Male; Prefrontal Cortex; Rats, Wistar; TRPV Cation Channels | 2015 |
A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Capsaicin; Mice; Mice, Inbred C57BL; Mice, Knockout; TRPV Cation Channels | 2015 |
Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
Topics: Action Potentials; Capsaicin; Humans; Lipid Bilayers; TRPV Cation Channels | 2015 |
[TRPV1 channel-mediated thermogenesis is a common mode for the Chinese pungent-hot or pungent-warm herbs to demonstrate their natures].
Topics: Adipose Tissue, Brown; Animals; Capsaicin; Energy Metabolism; Ganglia, Spinal; HEK293 Cells; Humans; Mice; Neurons; Plants, Medicinal; Temperature; Thermogenesis; TRPV Cation Channels | 2015 |
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
Topics: Acetanilides; Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Diterpenes; Male; Mibefradil; Mice; Pruritus; Purines; Receptors, Opioid; RNA Interference; Sensory Receptor Cells; Sulfides; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
TRPV1 receptors augment basal synaptic transmission in CA1 and CA3 pyramidal neurons in epilepsy.
Topics: Animals; Capsaicin; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Male; Pilocarpine; Pyramidal Cells; Rats, Wistar; RNA, Messenger; TRPV Cation Channels | 2016 |
Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels.
Topics: Acrylamides; Animals; Calcium; Capsaicin; Cells, Cultured; Cricetinae; Hydrogen-Ion Concentration; Pain; TRPV Cation Channels | 2016 |
Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Cannabinoids; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Indoles; Lumbosacral Region; Male; Morpholines; Naphthalenes; Rats, Wistar; Receptors, Opioid; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2016 |
Activation of TRPV1-dependent calcium oscillation exacerbates seawater inhalation-induced acute lung injury.
Topics: Actin Cytoskeleton; Acute Lung Injury; Administration, Inhalation; Animals; Calcium; Calcium Chelating Agents; Calcium Signaling; Capsaicin; Cell Line, Tumor; Cytosol; Disease Progression; Egtazic Acid; Extracellular Space; Fluorescence; Humans; Inflammation Mediators; Interleukin-1beta; Lung; Male; NF-kappa B; Phosphorylation; Proline; Rats, Sprague-Dawley; Seawater; Thiocarbamates; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2016 |
Evaluation of the antidepressant- and anxiolytic-like activity of α-spinasterol, a plant derivative with TRPV1 antagonistic effects, in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Body Temperature; Capsaicin; Depression; Male; Mice; Motor Activity; Stigmasterol; TRPV Cation Channels | 2016 |
Involvement of TRPV1 in the Olfactory Bulb in Rimonabant-Induced Olfactory Discrimination Deficit.
Topics: Animals; Capsaicin; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smell; TRPV Cation Channels | 2016 |
Effect of transient receptor potential vanilloid-1 on cough hypersensitivity induced by particulate matter 2.5.
Topics: Animals; Capillary Permeability; Capsaicin; Central Nervous System Diseases; Cough; Guinea Pigs; Herpesvirus 1, Suid; Hypersensitivity; Male; Particulate Matter; Respiratory Hypersensitivity; Signal Transduction; Substance P; TRPV Cation Channels; Vagus Nerve | 2016 |
Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling.
Topics: Acetic Acid; Acid Sensing Ion Channels; Acidosis; Animals; Capsaicin; Ganglia, Spinal; Male; Methoxyhydroxyphenylglycol; Neurons; Pain; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium Channel Blockers; Tetrodotoxin; TRPV Cation Channels | 2016 |
Activation of transient receptor potential vanilloid 1 accelerates re-endothelialization and inhibits neointimal formation after vascular injury.
Topics: Adenosine Triphosphate; Animals; Calcium Chelating Agents; Capsaicin; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Egtazic Acid; Endothelial Cells; GTP Phosphohydrolases; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Neointima; Re-Epithelialization; RNA Interference; Signal Transduction; Transfection; TRPV Cation Channels | 2017 |
Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Blood Pressure; Capsaicin; Carbamates; Desoxycorticosterone Acetate; Dose-Response Relationship, Drug; Drug Interactions; Hypertension; Male; Mesenteric Arteries; Morpholines; Phenylephrine; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Sodium Chloride; Vasoconstriction; Vasodilation | 2016 |
Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy.
Topics: Acute Disease; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Male; Membrane Transport Modulators; Morpholines; Naphthalenes; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2016 |
Inflammatory stimuli acutely modulate peripheral taste function.
Topics: Amiloride; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Body Weight; Capsaicin; Chorda Tympani Nerve; Dose-Response Relationship, Drug; Epithelial Sodium Channel Blockers; Female; Functional Laterality; Interleukin-6; Lipopolysaccharides; Quinine; Rats; Sensory Receptor Cells; Sodium; Sodium Acetate; Sodium Chloride; Taste Buds; Tomography Scanners, X-Ray Computed; Tumor Necrosis Factor-alpha | 2016 |
The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia.
Topics: Acute Lung Injury; Animals; Capsaicin; Disease Models, Animal; Endotoxemia; Lipopolysaccharides; Lung; Male; Mice; TRPV Cation Channels | 2016 |
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels | 2016 |
NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice.
Topics: Amphetamine; Animals; Antidepressive Agents; Capsaicin; Central Nervous System Stimulants; Depressive Disorder; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors; TRPV Cation Channels | 2016 |
TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation.
Topics: Animals; Body Temperature Regulation; Brain; Capsaicin; Diterpenes; Lipopolysaccharides; Mice; Mice, Knockout; Signal Transduction; STAT3 Transcription Factor; TRPV Cation Channels | 2016 |
Endovanilloids are potential activators of the trigeminovascular nocisensor complex.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Capsaicin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Dura Mater; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Laser-Doppler Flowmetry; Nociceptors; Peptide Fragments; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Calcitonin Gene-Related Peptide; Regional Blood Flow; Trigeminal Nerve; TRPV Cation Channels | 2016 |
Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides.
Topics: Animals; Anti-Ulcer Agents; Capsaicin; Curcumin; Cyclooxygenase 2; Female; Gastric Acid; Gastric Mucosa; Gastrins; Immersion; Male; Nitric Oxide Synthase Type II; Rats, Wistar; Restraint, Physical; RNA, Messenger; Stomach Ulcer; Stress, Psychological; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Water | 2016 |
Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.
Topics: Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents; Calcium Signaling; Capsaicin; HEK293 Cells; Humans; Inflammation; Mice; Mice, Knockout; Mustard Plant; Oximes; Pain; Plant Oils; Purines; TRPA1 Cation Channel | 2016 |
TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation.
Topics: Animals; Basolateral Nuclear Complex; Capsaicin; Excitatory Postsynaptic Potentials; Hypersensitivity; In Vitro Techniques; Male; Maternal Deprivation; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; TRPV Cation Channels; Up-Regulation | 2016 |
Co-administration of cannabidiol and capsazepine reduces L-DOPA-induced dyskinesia in mice: Possible mechanism of action.
Topics: Animals; Anti-Dyskinesia Agents; Arachidonic Acids; Brain; Cannabidiol; Capsaicin; Cyclooxygenase 2; Dyskinesia, Drug-Induced; Endocannabinoids; Extracellular Signal-Regulated MAP Kinases; Histones; Levodopa; Male; Mice, Inbred C57BL; NF-kappa B; Oxidopamine; Parkinsonian Disorders; Polyunsaturated Alkamides; PPAR gamma; Receptor, Cannabinoid, CB1; TRPV Cation Channels; Tyrosine 3-Monooxygenase | 2016 |
Duloxetine Reduces Oxidative Stress, Apoptosis, and Ca
Topics: Animals; Apoptosis; Calcium; Capsaicin; Caspase 3; Caspase 9; Duloxetine Hydrochloride; Ganglia, Spinal; Hippocampus; Ion Channel Gating; Male; Membrane Potential, Mitochondrial; Neurons; ortho-Aminobenzoates; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; TRPM Cation Channels; TRPV Cation Channels | 2017 |
Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Capsaicin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Humans; Janus Kinase 1; Ki-67 Antigen; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; RNA, Small Interfering; STAT3 Transcription Factor; Vanadates; Xenograft Model Antitumor Assays | 2017 |
Mitogen-Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation-Induced Cardiac Hypertrophy.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Down-Regulation; Endocannabinoids; Enzyme Inhibitors; Ligation; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Polyamines; Polyunsaturated Alkamides; Rats, Wistar; RNA, Small Interfering; Signal Transduction; TRPV Cation Channels | 2016 |
Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2.
Topics: Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Capsaicin; Cells, Cultured; Ceramides; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Partial Thromboplastin Time; Phosphorylation; Piperidines; Pyrazoles; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Thromboplastin; TRPV Cation Channels | 2016 |
Involvement of the TRPV1 receptor in plasma extravasation in airways of rats treated with an angiotensin-converting enzyme inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Bradykinin; Bronchi; Capillary Permeability; Capsaicin; Captopril; Male; Plasma; Rats; Rats, Wistar; Trachea; TRPV Cation Channels | 2016 |
Mechanistic Studies of Capsaicin-Induced Apnea in Rodents.
Topics: Animals; Animals, Newborn; Apnea; Brain Stem; Capsaicin; Mice, Inbred C57BL; Plethysmography; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; TRPV Cation Channels | 2017 |
TRPV1 Antagonist Suppresses Allergic Conjunctivitis in a Murine Model.
Topics: Acetanilides; Animals; Blotting, Western; Capsaicin; Conjunctivitis, Allergic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Fluorescent Antibody Technique, Indirect; Immunoglobulin E; Male; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Purines; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Pharmacological Properties of Propiverine Contribute to Improving Lower Urinary Tract Dysfunctions in Rats with Spinal Cord Injuries.
Topics: Animals; Atropine; Benzilates; Capsaicin; Female; Muscarinic Antagonists; Rats; Spinal Cord Injuries; Urinary Bladder; Urinary Bladder, Overactive; Verapamil | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Ericales; Ethanol; Female; Flavonoids; Gastrointestinal Motility; Glyburide; Histamine; Indomethacin; Male; Mice; Mucus; Naloxone; NG-Nitroarginine Methyl Ester; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Stomach Ulcer; Water; Yohimbine | 2017 |
Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.
Topics: Acrylamides; Animals; Animals, Newborn; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Medulla Oblongata; Membrane Potentials; Neurons; Rats; Rats, Wistar; Respiration; Spinal Cord; TRPV Cation Channels; Voltage-Sensitive Dye Imaging | 2017 |
Heat Sensing Receptor TRPV1 Is a Mediator of Thermotaxis in Human Spermatozoa.
Topics: Adult; Azoospermia; Capsaicin; Humans; Infertility, Male; Male; Neoplasms, Germ Cell and Embryonal; Sperm Motility; Spermatozoa; Taxis Response; Testicular Neoplasms; TRPV Cation Channels; Young Adult | 2016 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Activation of TRPM2 and TRPV1 Channels in Dorsal Root Ganglion by NADPH Oxidase and Protein Kinase C Molecular Pathways: a Patch Clamp Study.
Topics: Acetophenones; Action Potentials; Animals; Calcium Signaling; Capsaicin; Cells, Cultured; Cinnamates; Ganglia, Spinal; Indoles; Male; Maleimides; NADPH Oxidases; Neurons; ortho-Aminobenzoates; Oxidative Stress; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; TRPM Cation Channels; TRPV Cation Channels | 2017 |
Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Carbon Monoxide; Gastric Mucosa; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Lipid Peroxidation; Male; Nitric Oxide; Organometallic Compounds; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sensory Receptor Cells; Stomach; Sulfides | 2018 |
Role of transient receptor potential vanilloid 1 in the modulation of airway smooth muscle tone and calcium handling.
Topics: Acetylcholine; Animals; Calcium; Capsaicin; Guinea Pigs; Humans; Immunohistochemistry; Methacholine Chloride; Mice; Muscle Contraction; Muscle, Smooth; RNA, Messenger; Trachea; TRPV Cation Channels | 2017 |
Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents.
Topics: Aminopyridines; Animals; Capsaicin; Excitatory Postsynaptic Potentials; Hydrazones; Male; Patch-Clamp Techniques; Piperazines; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Synaptic Transmission; TRPV Cation Channels; Visceral Afferents | 2017 |
Antinociceptive effect of natural and synthetic alkamides involves TRPV1 receptors.
Topics: Amides; Analgesics; Animals; Asteraceae; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Facial Pain; Female; Mice; Pain Measurement; TRPV Cation Channels | 2017 |
Vincristine-induced peripheral neuropathic pain and expression of transient receptor potential vanilloid 1 in rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression; Humans; Male; Neuralgia; Neurons; Rats, Wistar; Ruthenium Red; TRPV Cation Channels; Up-Regulation; Vincristine | 2017 |
Role of peripheral and central TRPV1 receptors in facial heat hyperalgesia in streptozotocin-induced diabetic rats.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Diterpenes; Face; Facial Pain; Hot Temperature; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Trigeminal Ganglion; TRPV Cation Channels | 2017 |
l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.
Topics: Animals; Arginine; Calcium Signaling; Capsaicin; Down-Regulation; Gastrointestinal Motility; HEK293 Cells; Humans; Intestine, Small; Lysine; Male; Membrane Transport Modulators; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Ornithine; Rats; Recombinant Proteins; Ruthenium Red; TRPV Cation Channels; Up-Regulation | 2017 |
Capsaicin-induced rapid neutrophil leukocyte activation in the rat urinary bladder microcirculatory bed.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Male; Microcirculation; Neurons, Afferent; Neutrophils; Rats; Rats, Sprague-Dawley; Substance P; Urinary Bladder | 2018 |
4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation.
Topics: A549 Cells; Asteraceae; Caffeic Acids; Capsaicin; Cell Movement; Cyclooxygenase 2; Humans; Plant Extracts; Quinic Acid; TRPV Cation Channels | 2017 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; CDX2 Transcription Factor; Curcumin; Cyclooxygenase 2 Inhibitors; Denervation; Down-Regulation; Ethanol; Female; Gastric Mucosa; Gastrins; Gene Expression; Heme Oxygenase (Decyclizing); Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Lactones; Male; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; RNA, Messenger; Stomach Diseases; Sulfones; Superoxide Dismutase; TRPV Cation Channels; Up-Regulation | 2018 |
Ethanol potentiates heat response in the carotid artery via TRPV1.
Topics: Animals; Capsaicin; Carotid Arteries; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Hot Temperature; Rabbits; TRPV Cation Channels; Vasoconstriction | 2017 |
Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations.
Topics: Acetanilides; Action Potentials; Animals; Brain Stem; Capsaicin; Eugenol; GABA-A Receptor Antagonists; Neurons; Purines; Rats; Rats, Wistar; Respiration; Spinal Cord; Transient Receptor Potential Channels | 2018 |
Transient receptor potential vanilloid 1 inhibitors block laparotomy- and opioid-induced infarct size reduction in rats.
Topics: Analgesics, Opioid; Animals; Capsaicin; Male; Myocardial Infarction; Pyridines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2017 |
Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nociception; Oxytocin; Protein Structure, Quaternary; Receptors, Oxytocin; TRPV Cation Channels | 2017 |
TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder.
Topics: Adenosine Triphosphate; Animals; Capsaicin; Cells, Cultured; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Purinergic P2X Receptor Agonists; Receptors, Purinergic P2X; TRPV Cation Channels; Urinary Bladder; Urothelium | 2018 |
Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cerebral Cortex; Choice Behavior; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2018 |
TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain.
Topics: Animals; Capsaicin; Chemokine CCL2; Chronic Pain; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pelvic Pain; Receptors, CCR2; Signal Transduction; Toll-Like Receptor 4; TRPV Cation Channels; Urinary Tract Infections; Uropathogenic Escherichia coli | 2018 |
Developmental and behavioral effects in neonatal and adult mice following prenatal activation of endocannabinoid receptors by capsaicin.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Capsaicin; Embryonic Development; Female; Injections, Intraperitoneal; Male; Maze Learning; Mice, Inbred BALB C; Morpholines; Naphthalenes; Pregnancy; Prenatal Exposure Delayed Effects; Receptor Cross-Talk; Receptors, Cannabinoid; Rimonabant; TRPV Cation Channels | 2019 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels | 2018 |
α7 Nicotinic acetylcholine receptor contributes to the alleviation of lung ischemia-reperfusion injury by transient receptor potential vanilloid type 1 stimulation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Benzamides; Bridged Bicyclo Compounds; Capsaicin; Disease Models, Animal; Down-Regulation; Humans; Lung; Lung Injury; Male; Mice; Mice, Knockout; Reperfusion Injury; Treatment Outcome; TRPV Cation Channels | 2018 |
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Ganglia, Spinal; Hyperalgesia; Lysergic Acid Diethylamide; Male; Maze Learning; Neuralgia; Piperazines; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Swimming | 2019 |
Inhibitions of anandamide transport and FAAH synthesis decrease apoptosis and oxidative stress through inhibition of TRPV1 channel in an in vitro seizure model.
Topics: Amidohydrolases; Animals; Apoptosis; Arachidonic Acids; Calcium Signaling; Capsaicin; Cell Line, Tumor; Disease Models, Animal; Endocannabinoids; Hippocampus; Humans; Male; Oxidative Stress; Polyunsaturated Alkamides; Rats; Rats, Wistar; Seizures; TRPV Cation Channels | 2019 |
[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa.
Topics: Amiloride; Animals; Capsaicin; Catechols; Colon; Epithelial Sodium Channel Blockers; Fatty Alcohols; Gastrointestinal Agents; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Membrane Potentials; Membrane Transport Modulators; Muscle, Smooth; Oximes; Rats, Sprague-Dawley; Sodium, Dietary; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calcium; Capsaicin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Hippocampus; Neurites; Neuronal Outgrowth; PC12 Cells; Primary Cell Culture; Rats; Rats, Wistar; TRPV Cation Channels | 2018 |
Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Apomorphine; Arginine; Capsaicin; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Exploratory Behavior; Glutamic Acid; Male; Microinjections; Nitric Oxide; Nitroprusside; Rats; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Swimming | 2019 |
Inhibition of Transient Receptor Potential Vanilloid 1 Attenuates Blood-Brain Barrier Disruption after Traumatic Brain Injury in Mice.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries, Traumatic; Capsaicin; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; TRPV Cation Channels | 2019 |
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA3 Region, Hippocampal; Capsaicin; Cognition; Electrodes, Implanted; Gamma Rhythm; Gene Expression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtomy; Models, Biological; Peptide Fragments; Pyramidal Cells; Recombinant Proteins; Tissue Culture Techniques; TRPV Cation Channels | 2018 |
Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Acetylation; Adipogenesis; Adipose Tissue; Animals; Bone Morphogenetic Proteins; Capsaicin; CCAAT-Enhancer-Binding Proteins; Diet, High-Fat; Epididymis; Feeding Behavior; Ion Channel Gating; Lipid Metabolism; Male; Mice; PPAR alpha; PPAR gamma; RNA, Messenger; Sirtuin 1; Thermogenesis; Troglitazone; TRPV Cation Channels; Uncoupling Protein 1; Weight Loss | 2019 |
Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types.
Topics: Animals; Antineoplastic Agents; Capsaicin; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice, Nude; Molecular Structure; Neoplasms; Structure-Activity Relationship; TRPV Cation Channels; Xenograft Model Antitumor Assays | 2019 |
Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach.
Topics: Animals; Capsaicin; Cockroaches; Isothiocyanates; Menthol; Temperature; Thymol; TRPV Cation Channels | 2018 |
The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor.
Topics: Alginates; Allosteric Regulation; Analgesics; Animals; Arachidonic Acids; Biosensing Techniques; Body Temperature; Capsaicin; Cross-Linking Reagents; Electrochemical Techniques; Endocannabinoids; Fever; Pain; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Starch; Taste Buds; TRPV Cation Channels | 2019 |
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hydrogen Sulfide; Hydroxylamine; Hyperalgesia; Imidazoles; Nociception; Purines; Rats, Wistar; Skin; Spinal Nerve Roots; Sulfites; Transient Receptor Potential Channels | 2019 |
Effect of TRPV1 on Activity of Isoforms of Constitutive Nitric Oxide Synthase during Regulation of Bicarbonate Secretion in the Stomach.
Topics: Amiloride; Animals; Bicarbonates; Capsaicin; Gastric Mucosa; Gene Expression Regulation; Hydrogen-Ion Concentration; Indazoles; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitroarginine; Osmolar Concentration; Perfusion; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride; Stomach; TRPV Cation Channels; Vagotomy | 2019 |
Accumulation of intramyocyte TRPV1-mediated calcium during heat stress is inhibited by concomitant muscle contractions.
Topics: Animals; Calcium; Capsaicin; Heat Stress Disorders; Heat-Shock Response; Isometric Contraction; Male; Muscle Contraction; Muscle Fibers, Skeletal; Phosphorylation; Rats; Rats, Wistar; TRPV Cation Channels | 2019 |
Molecular and functional insights into Transient Receptor Potential Vanilloid 1 (TRPV1) in bull spermatozoa.
Topics: Acrosome Reaction; Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Cattle; Endocannabinoids; Male; Polyunsaturated Alkamides; Sperm Capacitation; Sperm Motility; Spermatozoa; TRPV Cation Channels | 2019 |
Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism.
Topics: Animals; Brain Stem; Capsaicin; Female; Glycine; Hypoglossal Nerve; Inhibitory Postsynaptic Potentials; Male; Motor Neurons; Potassium Channels; Rats; Rats, Wistar; TRPV Cation Channels | 2019 |
Baicalein inhibits matrix metalloproteinase 1 expression via activation of TRPV1-Ca-ERK pathway in ultraviolet B-irradiated human dermal fibroblasts.
Topics: Anthracenes; Antioxidants; Apoptosis; Arachidonate 12-Lipoxygenase; Calcium; Capsaicin; Cytosol; Dermis; Egtazic Acid; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavanones; Humans; Leukotrienes; Matrix Metalloproteinase 1; NF-E2-Related Factor 2; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Skin; Skin Aging; TRPV Cation Channels; Ultraviolet Rays | 2019 |
The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis.
Topics: Animals; Apoptosis; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Endoplasmic Reticulum Stress; Female; Humans; Isoquinolines; Male; Mice; Mice, Nude; Mitochondria; Mouth Neoplasms; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Xenograft Model Antitumor Assays | 2019 |
Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.
Topics: Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Fibromyalgia; Laser Therapy; Low-Level Light Therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Musculoskeletal Pain; Protein Precursors; Signal Transduction; Substance P; Tachykinins; TRPV Cation Channels | 2019 |
Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Diterpenes; Ganglia, Spinal; HEK293 Cells; Humans; Neurons; Rats, Sprague-Dawley; TRPV Cation Channels | 2019 |
Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1.
Topics: Animals; Capsaicin; Cornea; Dry Eye Syndromes; Electrophysiological Phenomena; Lacrimal Apparatus; Menthol; Neurons, Afferent; Rats; Sensory System Agents; Trigeminal Ganglion; TRPM Cation Channels; TRPV Cation Channels | 2019 |
Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium.
Topics: Camphanes; Cannabinoid Receptor Antagonists; Capsaicin; Cell Proliferation; Cell Survival; Dopamine; Endometriosis; Endometrium; Female; Humans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stromal Cells | 2019 |
Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat.
Topics: Animals; Arrhythmias, Cardiac; Capsaicin; Cardiotonic Agents; Ganglia, Spinal; Genetic Therapy; Injections, Spinal; Lentivirus; MAP Kinase Signaling System; Myocardial Infarction; Myocardial Reperfusion Injury; Nerve Growth Factor; Patch-Clamp Techniques; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; TRPV Cation Channels | 2019 |
Transient receptor potential vanilloid 1 mediates cocaine reinstatement via the D1 dopamine receptor in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Benzazepines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Cocaine; Conditioning, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nucleus Accumbens; Receptors, Dopamine D1; TRPV Cation Channels | 2019 |
The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
Topics: Animals; Biomarkers; Biopterins; Blood Pressure; Capsaicin; Drug Evaluation, Preclinical; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Resistance | 2019 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
The
Topics: Animals; Arthropod Venoms; Behavior, Animal; Calcium Signaling; Capsaicin; Female; Ganglia, Spinal; Larva; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Sebaceous Glands; TRPV Cation Channels | 2019 |
Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Calcium Channels; Capsaicin; Chelating Agents; Disease Models, Animal; Egtazic Acid; Hippocampus; Learning; Memory Disorders; Mice; Mice, Knockout; Nociceptors; tau Proteins; TRPV Cation Channels | 2020 |
Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1.
Topics: Animals; Capsaicin; Fever; Gene Expression Regulation; Heart Rate; Rats; TRPV Cation Channels; Ventricular Function, Left | 2020 |
Effects of inhalation of sevoflurane at different concentrations on TRPV1 in airways of rats at different developmental stages.
Topics: Administration, Inhalation; Age Factors; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Respiration; Sevoflurane; Substance P; Trachea; TRPV Cation Channels | 2020 |
Amelioration from the ocular irritant Capsaicin: development and assessment of a Capsazepine
Topics: Animals; Capsaicin; Chitosan; Cornea; Female; Gels; Humans; Irritants; Male; Poloxamer; Rabbits; Rats; Rats, Wistar | 2020 |
Role of TRPV1/TRPV3 channels in olanzapine-induced metabolic alteration: Possible involvement in hypothalamic energy-sensing, appetite regulation, inflammation and mesolimbic pathway.
Topics: Animals; Appetite Regulation; Capsaicin; Coloring Agents; Energy Metabolism; Female; Furans; Gene Expression Regulation; Glucose Tolerance Test; Hypoglycemic Agents; Hypothalamus; Inflammation; Metformin; Mice; Mice, Inbred BALB C; Motor Activity; Olanzapine; Ruthenium Red; Sensory System Agents; TRPV Cation Channels | 2020 |
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Male; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Receptors, N-Methyl-D-Aspartate; Ruthenium Red; Triterpenes; TRPV Cation Channels; Zebrafish; Zebrafish Proteins | 2020 |
Antiallodynic effect of PhAR-DBH-Me involves cannabinoid and TRPV1 receptors.
Topics: Animals; Antineoplastic Agents; Arachidonic Acids; Azabicyclo Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Cisplatin; Endocannabinoids; Female; Hyperalgesia; Injections, Intraperitoneal; Ligation; Models, Animal; Neuralgia; Oleic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar; Spinal Nerves; TRPV Cation Channels; Vagus Nerve Stimulation | 2020 |
Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney.
Topics: Animals; Arterial Pressure; Baroreflex; Blood Volume; Capsaicin; Chronic Disease; Disease Models, Animal; Diuresis; Heart Rate; Hypoxia; Infusions, Intravenous; Kidney; Male; Natriuresis; Rats, Wistar; Saline Solution; Sympathetic Nervous System; Time Factors; TRPV Cation Channels; Urodynamics | 2021 |
Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis.
Topics: Animals; Behavior, Animal; Capsaicin; Cartilage, Articular; Disease Models, Animal; Female; Ganglia, Spinal; Male; Mice, Inbred C57BL; Microscopy, Fluorescence; Osteoarthritis; Pain; Sensory System Agents; Sex Factors; Stifle; TRPV Cation Channels | 2021 |
CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; Endocannabinoids; Female; Guinea Pigs; Ligands; Mechanotransduction, Cellular; Mucous Membrane; Muscle, Smooth; Neurons, Afferent; Pyrazoles; Receptor, Cannabinoid, CB2; TRPV Cation Channels; Urinary Bladder | 2021 |
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels | 2021 |
Capsazepine decreases corneal pain syndrome in severe dry eye disease.
Topics: Animals; Capsaicin; Cornea; Dry Eye Syndromes; Male; Mice; Mice, Inbred C57BL; Pain; Syndrome; TRPV Cation Channels | 2021 |
Role of the Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the Regulation of Nitric Oxide Release in Wistar Rat Aorta.
Topics: Animals; Aorta; Biopterins; Capsaicin; Cyclic GMP; Endothelial Cells; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; TRPV Cation Channels | 2021 |
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch.
Topics: Acetanilides; Animals; Calcium; Capsaicin; Female; Ganglia, Spinal; Gene Expression; Histamine; Male; Methylhistamines; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Molecular Imaging; Primary Cell Culture; Pruritus; Purines; Ruthenium Red; Sensory Receptor Cells; Signal Transduction; TRPA1 Cation Channel; TRPV Cation Channels | 2021 |
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
Membrane Interactivity of Capsaicin Antagonized by Capsazepine.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Capsaicin; Lipid Bilayers; Membranes | 2022 |
Intrarectal Capsazepine Administration Modulates Colonic Mucosal Health in Mice.
Topics: Animals; Capsaicin; Colon; Inflammatory Bowel Diseases; Mice; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Bioflavonoid exerts analgesic and anti-inflammatory effects via transient receptor potential 1 channel in a rat model.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Flavonoids; Kaempferols; Rats; Transient Receptor Potential Channels; TRPV Cation Channels | 2022 |
Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy.
Topics: Animals; Capsaicin; Diabetes Mellitus; Diabetic Nephropathies; Doxorubicin; Mice; Mice, Knockout; Transient Receptor Potential Channels; TRPC Cation Channels; TRPC6 Cation Channel | 2023 |
Neuroprotective effect of transient receptor potential Vanilloid 1 agonist capsaicin in Alzheimer's disease model induced with okadaic acid.
Topics: Alzheimer Disease; Animals; Antineoplastic Agents; Capsaicin; Humans; Neuroprotective Agents; Okadaic Acid; Rats; TRPV Cation Channels | 2023 |
L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells.
Topics: Antineoplastic Agents; Calcium; Capsaicin; Carnitine; Epithelial Cells; Humans; TRPV Cation Channels | 2023 |