caprylates has been researched along with cpi 613 in 24 studies
| Studies (caprylates) | Trials (caprylates) | Recent Studies (post-2010) (caprylates) | Studies (cpi 613) | Trials (cpi 613) | Recent Studies (post-2010) (cpi 613) |
|---|---|---|---|---|---|
| 5,061 | 100 | 2,339 | 34 | 6 | 33 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 13 (54.17) | 2.80 |
| Authors | Studies |
|---|---|
| Boteju, LW; Lee, KC; Maturo, C; Rodriguez, R; Sheldon, A; Shorr, R | 1 |
| Bingham, PM; Gupta, S; Howell, K; Karnik, S; Lee, K; Lem, J; Marecek, J; Maturo, C; Piramzadian, A; Rodriguez, R; Schauble, A; Shorr, R; Stuart, SD; Zachar, Z | 1 |
| Dralle, S; Ellis, LR; Harrelson, R; Hurd, D; Isom, S; Lee, K; Levitan, D; Luddy, J; Lyerly, S; Manuel, M; Maturo, C; Miller, LD; Pardee, TS; Powell, BL; Rodriguez, R; Stadelman, KM | 1 |
| Dörsam, B; Fahrer, J | 1 |
| Alistar, A; Bonomi, M; Chan, MD; Isom, S; Lamar, ZS; Lycan, TW; Miller, AA; Pardee, TS; Petty, WJ; Ruiz, J | 1 |
| Gaunitz, F; Meixensberger, J; Oppermann, H; Schnabel, L | 1 |
| Behura, SK; Green, JA; Ji, T; Mordhorst, BR; Murphy, SL; Prather, RS; Rojas Salazar, S; Ross, RM; Samuel, MS; Wells, KD | 1 |
| Egawa, Y; Kito, Y; Moriki, T; Saigo, C; Takeuchi, T | 1 |
| Green, JA; Kerns, KC; Mordhorst, BR; Murphy, SL; Prather, RS; Ross, RM; Schauflinger, M; Sutovsky, P; Wells, KD; Zigo, M | 1 |
| Alistar, AT; Buyse, ME; Luther, S; Pardee, TS; Philip, PA; Rocha Lima, CM; Van Cutsem, E | 1 |
| Cheng, K; Fetse, JP; Jain, A; Li, Y; Lin, CY; Liu, H; Zhao, Z | 1 |
| Chen, Z; Gao, L; He, L; Huang, J; Huang, Z; Liu, M; Tang, Y; Teng, Y; Xu, Z; Yang, D | 1 |
| Iwata, Y; Kito, Y; Saigo, C; Sakuratani, T; Takeuchi, T; Yasufuku, I; Yoshida, K | 1 |
| Hewitson, TD; Smith, ER | 1 |
| Asakage, T; Inazawa, J; Inoue, J; Kishikawa, M; Nakajima, Y; Tsuda, H | 1 |
| Apaydin, M; Brink, M; Faulkner, P; Hala, D; He, K; Hernout, B; Ivanov, I; Kamalanathan, M; Petersen, LH; Qian, X; Simons, K | 1 |
| Dvořák, A; Koncošová, M; Křížová, I; Rimpelová, S; Ruml, T; Rumlová, M; Tomášová, P; Vítek, L; Vrzáčková, N; Zelenka, J | 1 |
| Arnold, C; Boengler, K; Brunner, T; Christmann, M; Demuth, P; Fahrer, J; Huber, M; Linnebacher, M; Rasenberger, B; Seiwert, N; Wittmann, S | 1 |
| Ding, Z; Ke, Y; Lang, L; Loveless, R; Qiu, P; Saba, NF; Shay, C; Teng, Y; Wang, F; Xie, J; Zhao, X | 1 |
| Boteju, A; Boteju, L; Hu, K; Kassahun, K; Luther, S; Reddy, N; Reddy, VB; Sheldon, A; Shen, L | 1 |
| Anderson, R; Bhave, RR; Chou, JW; Dralle, S; Ellis, LR; Howard, DS; Isom, S; Lyerly, S; Manuel, M; Miller, LD; Pardee, TS; Pladna, KM; Powell, BL; Schramm, NJ | 1 |
| Goldstein, L; Joksch, M; Krause, B; Kumstel, S; Lindner, T; Schönrogge, M; Schreiber, T; Stenzel, J; Vollmar, B; Wendt, EHU; Zechner, D; Zhang, X | 1 |
| Bingham, PM; Dahan, M; Guardado Rivas, MO; Shorr, R; Stuart, SD; Thach, D; Zachar, Z | 1 |
| Chen, J; Chen, X; Liu, N; Peng, C; Tao, Q; Wu, J; Yan, M | 1 |
1 review(s) available for caprylates and cpi 613
| Article | Year |
|---|---|
The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caprylates; Drug Discovery; Energy Metabolism; Humans; Mitochondria; Molecular Structure; Neoplasms; Signal Transduction; Structure-Activity Relationship; Sulfides; Thioctic Acid | 2016 |
4 trial(s) available for caprylates and cpi 613
| Article | Year |
|---|---|
A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Caprylates; Cell Line, Tumor; Drug Administration Schedule; Female; Hematologic Neoplasms; Humans; Leukemia; Male; Middle Aged; Mitochondria; Neoplasm Staging; Positron-Emission Tomography; Sulfides; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2014 |
A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Caprylates; Cell Line, Tumor; Female; Humans; Kaplan-Meier Estimate; Lung; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Small Cell Lung Carcinoma; Sulfides; Topoisomerase I Inhibitors; Topotecan | 2016 |
A Phase III open-label trial to evaluate efficacy and safety of CPI-613 plus modified FOLFIRINOX (mFFX) versus FOLFIRINOX (FFX) in patients with metastatic adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Caprylates; Female; Fluorouracil; Follow-Up Studies; Humans; International Agencies; Irinotecan; Leucovorin; Male; Middle Aged; Oxaliplatin; Pancreatic Neoplasms; Prognosis; Prospective Studies; Sulfides; Survival Rate | 2019 |
Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Caprylates; Cytarabine; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Sulfides; Treatment Outcome | 2022 |
19 other study(ies) available for caprylates and cpi 613
| Article | Year |
|---|---|
Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism.
Topics: Animals; Antineoplastic Agents; Caprylates; Cell Line, Tumor; Chromatography, Liquid; Glucuronides; Half-Life; Humans; Liver; Mice; Microsomes, Liver; Neoplasms; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfides; Sulfoxides; Swine; Swine, Miniature; Tandem Mass Spectrometry | 2011 |
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.
Topics: Animals; Antineoplastic Agents; Antioxidants; Caprylates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; Humans; Mice; Mitochondria; Neoplasm Transplantation; Neoplasms; Oxidation-Reduction; Oxidative Phosphorylation; Pyruvate Dehydrogenase Complex; Sulfides; Thioctic Acid; Transplantation, Heterologous | 2011 |
Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Antineoplastic Agents; Caprylates; Carnosine; Cell Line, Tumor; Citric Acid Cycle; Energy Metabolism; Humans; Oxidative Phosphorylation; Pyruvic Acid; Sulfides | 2016 |
Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation.
Topics: Animals; Caprylates; Cell Proliferation; Cells, Cultured; Cellular Reprogramming; Cellular Reprogramming Techniques; Culture Media, Conditioned; Fetus; Fibroblasts; Gene Expression; Glycolysis; Pentanoic Acids; Sulfides; Swine | 2018 |
Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma.
Topics: Animals; Autophagy; Caprylates; Cell Line, Tumor; Chloroquine; Drug Delivery Systems; Energy Metabolism; Humans; Mice; Mice, SCID; Mitochondria; Sarcoma, Clear Cell; Sulfides; Xenograft Model Antitumor Assays | 2018 |
Pharmacologic treatment with CPI-613 and PS48 decreases mitochondrial membrane potential and increases quantity of autolysosomes in porcine fibroblasts.
Topics: Animals; Autophagy; Caprylates; Fibroblasts; Lysosomes; Membrane Potential, Mitochondrial; Microscopy, Electron; Mitochondria; Pentanoic Acids; Sulfides; Swine | 2019 |
Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma.
Topics: Animals; Caprylates; Cell Line, Tumor; Cell Proliferation; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Nanoparticles; Pancreatic Neoplasms; Pancreatic Stellate Cells; Pyrazoles; Pyrroles; Stromal Cells; Sulfides; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Apoptosis; Caprylates; Cell Line, Tumor; Humans; Lipid Metabolism; Mitochondria; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Sulfides | 2020 |
Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Caprylates; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Signal Transduction; Stomach Neoplasms; Sulfides; Transcription Factors | 2021 |
TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts.
Topics: Acetyl Coenzyme A; Acetylation; Actins; Caprylates; Collagen Type I; Dichloroacetic Acid; Down-Regulation; Fibroblasts; Humans; Kidney; Mutation; Oxidative Phosphorylation; Protein Phosphatase 2C; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Sulfides; Transforming Growth Factor beta1 | 2020 |
Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.
Topics: Animals; Caprylates; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Heterografts; Humans; Hyaluronan Receptors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Pyruvate Dehydrogenase Complex; Sulfides; Up-Regulation | 2021 |
An integrated in vivo and in silico analysis of the metabolism disrupting effects of CPI-613 on embryo-larval zebrafish (Danio rerio).
Topics: Adenosine Triphosphate; Animals; Caprylates; Computer Simulation; Down-Regulation; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Genome-Wide Association Study; Larva; Oxygen Consumption; Sulfides; Transcriptome; Up-Regulation; Zebrafish | 2021 |
Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment.
Topics: Acidosis; Adaptation, Physiological; Antineoplastic Agents; Caprylates; Citric Acid Cycle; Energy Metabolism; Glucose; Glycolysis; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mitochondria; Neoplasms; Oxidative Stress; Sulfides; Tumor Cells, Cultured; Tumor Microenvironment | 2021 |
The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner.
Topics: Animals; Antineoplastic Agents; Caprylates; Cell Line, Tumor; Colorectal Neoplasms; Humans; Male; Mice; Sulfides; Survival Analysis | 2022 |
Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer.
Topics: Animals; Apoptosis; Caprylates; Cell Line, Tumor; Cell Survival; Glutamine; Head and Neck Neoplasms; Humans; Mice; Sulfides | 2021 |
In Vitro and In Vivo Metabolism of a Novel Antimitochondrial Cancer Metabolism Agent, CPI-613, in Rat and Human.
Topics: Animals; Caprylates; Hepatocytes; Humans; Neoplasms; Rats; Sulfides | 2022 |
Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.
Topics: Animals; Caprylates; Cell Line, Tumor; Humans; Lactic Acid; Mice; Pancreatic Neoplasms; Positron Emission Tomography Computed Tomography; Sulfides | 2022 |
Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613.
Topics: Antineoplastic Agents; Caprylates; Carcinoma; Fatty Acids; Humans; Sulfides | 2022 |
Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis.
Topics: Animals; B7-H1 Antigen; Caprylates; Immunotherapy; Melanoma; Mice; Tumor Microenvironment | 2023 |