Page last updated: 2024-09-03

caprylates and aliskiren

caprylates has been researched along with aliskiren in 2 studies

Compound Research Comparison

Studies (caprylates)	Trials (caprylates)	Recent Studies (post-2010) (caprylates)	Studies (aliskiren)	Trials (aliskiren)	Recent Studies (post-2010) (aliskiren)
5,061	100	2,339	978	211	611

Protein Interaction Comparison

Protein	Taxonomy	aliskiren (IC50)
Renin	Homo sapiens (human)	0.001
Renin-1	Mus musculus (house mouse)	0.0045
Renin	Rattus norvegicus (Norway rat)	0.084
Cytochrome P450 3A4	Homo sapiens (human)	0.0004
Cytochrome P450 2C9	Homo sapiens (human)	0.0023
Renin	Macaca mulatta (Rhesus monkey)	0.0012
Renin	Oryctolagus cuniculus (rabbit)	0.011

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baum, HP; Cohen, NC; Cumin, F; Fuhrer, W; Göschke, R; Gruetter, MG; Maibaum, J; Rahuel, J; Rigollier, P; Schilling, W; Schnell, CR; Stutz, S; Wood, JM; Yamaguchi, Y	1
Chénard, E; Cusson, JP; Guesné, S; Hanessian, S	1

Other Studies

2 other study(ies) available for caprylates and aliskiren

Article	Year
Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. Journal of medicinal chemistry, 2007, Oct-04, Volume: 50, Issue:20 Topics: Administration, Oral; Amides; Animals; Antihypertensive Agents; Blood Pressure; Callithrix; Caprylates; Crystallography, X-Ray; Fumarates; Heart Rate; Humans; Kinetics; Models, Molecular; Molecular Structure; Protein Binding; Renin; Stereoisomerism; Structure-Activity Relationship	2007
Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren. The Journal of organic chemistry, 2014, Oct-17, Volume: 79, Issue:20 Topics: Amides; Caprylates; Catalysis; Crystallography, X-Ray; Esters; Fumarates; Lactones; Molecular Structure; Stereoisomerism	2014

Article

Year

Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.

Journal of medicinal chemistry, 2007, Oct-04, Volume: 50, Issue:20

Topics: Administration, Oral; Amides; Animals; Antihypertensive Agents; Blood Pressure; Callithrix; Caprylates; Crystallography, X-Ray; Fumarates; Heart Rate; Humans; Kinetics; Models, Molecular; Molecular Structure; Protein Binding; Renin; Stereoisomerism; Structure-Activity Relationship

2007

Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren.

The Journal of organic chemistry, 2014, Oct-17, Volume: 79, Issue:20

Topics: Amides; Caprylates; Catalysis; Crystallography, X-Ray; Esters; Fumarates; Lactones; Molecular Structure; Stereoisomerism

2014