Compounds > capecitabine
Page last updated: 2024-08-24

capecitabine and floxuridine

capecitabine has been researched along with floxuridine in 63 studies

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (9.52)18.2507
2000's29 (46.03)29.6817
2010's27 (42.86)24.3611
2020's1 (1.59)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Sekiguchi, F1
Fukase, Y; Ishikawa, T; Ishitsuka, H; Sekiguchi, F; Yamamoto, T1
Ishikawa, T; Ishitsuka, H; Miwa, M; Mori, K; Nishida, M; Sawada, N; Shimma, N; Umeda, I; Ura, M1
González Barón, M1
Endo, M; Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Shinbori, N; Tanaka, Y1
Adenis, A; Conroy, T; Paillot, B1
Arasaki, M; Horii, I; Ishitsuka, H; Kohchi, Y; Kuruma, I; Masubuchi, K; Miwa, M; Murasaki, C; Sawada, N; Shimma, N; Tahara, H; Umeda, I; Ura, M1
Matsuzaki, A; Morita, T; Tokue, A1
Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T1
Casado, FJ; Fernández-Veledo, S; García-Manteiga, JM; Guillén-Gómez, E; Larrayoz, IM; Lloberas, J; Lostao, MP; Mata, JF; Pastor-Anglada, M1
Baldwin, SA; Cass, CE; Clarke, ML; Coupland, RW; Dabbagh, L; Jennings, LL; Koski, SL; Mackey, JR; Santos, CL; Vsianska, M; Young, JD1
Brunner, M; Eichler, HG; Locker, G; Mader, RM; Mueller, M; Rizovski, B; Schrolnberger, C; Steger, GG; Wenzel, C1
Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL1
Miwa, K; Nishimura, G1
Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Magné, N; Marchetti, S; Milano, G; Renée, N; Tiffon, C1
Heerschap, A; Kamm, YJ; Klomp, DW; Punt, CJ; van Laarhoven, HW1
Stadler, WM1
Chiba, K; Hosakawa, M; Katoh, M; Nakajima, M; Tabata, T; Tokudome, S; Yokoi, T1
Akimoto, T; Hasegawa, K; Kishimoto, Y; Morimoto, Y; Sawai, T1
Ebi, H; Igarashi, T; Kawada, K; Minami, H; Saeki, T; Sasaki, Y; Sigeoka, Y; Ueda, R; Usubuchi, N1
Fujioka, A; Fukushima, M; Ikeda, K; Kitazato, K; Nakagawa, F; Ohshimo, H; Okabe, H; Takechi, T1
Fujimoto-Ouchi, K; Hata, K; Hiraga, T; Ikeda, F; Kitagaki, J; Tanaka, Y; Yoneda, T1
Hamada, K; Kakihara, Y; Kubota, K; Mori, S; Nakagawa, A; Suzuki, N; Tachibana, M; Tagaya, N1
Guichard, SM; Jodrell, DI; Mayer, I1
Lokiec, F; Rezaí, K; Urien, S1
Ebi, H; Minami, H1
Fukumitsu, T; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Sasatomi, T; Shirouzu, K; Torigoe, S; Yamashita, N; Yanagawa, T1
Cao, D; Pizzorno, G; Wan, L; Yan, R; Zeng, J1
Cao, D; Pizzorno, G; Wan, L; Yan, R1
Horii, I; Kawashima, A; Kobayashi, K; Nakano, K; Shindoh, H; Shishido, N1
Ando, H; Bykowski, C; Dhananjeyan, MR; Erhardt, PW; Liu, J; Sarver, JG; Trendel, JA1
Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E1
Amano, M; Fukunaga, M; Ikeda, K; Ikeda, M; Ikenaga, M; Ishida, H; Kato, T; Mishima, H; Monden, M; Murata, K; Ohnishi, T; Ota, H; Sakamoto, J; Sekimoto, M; Tominaga, S1
Murakami, S; Yamamoto, Y1
Baldwin, J; Basche, M; Britten, CD; Camidge, DR; Darstein, C; Finn, RS; Gail Eckhardt, S; Gore, L; Holden, SN; Leong, S; Musib, L; O'Bryant, CL; Thornton, D1
Beijnen, JH; Rosing, H; Schellens, JH; Vainchtein, LD1
Alberts, SR; Bolton, JS; Dentchev, T; Lai, LL; Mahoney, MR; Molina, R; Nagorney, DM; O'Connell, MJ; Roh, MS; Schwarz, RE; Smyrk, TC; Wagman, L; Weiland, TL1
Nakayama, T; Noguchi, S1
Genda, T; Hori, S; Miki, A; Nakajima, M; Satoh, H; Sawada, Y; Suehira, M1
Czejka, M; Farkouh, A; Gruenberger, B; Scheithauer, W; Schueller, J1
Czejka, M; Farkouh, A; Scheithauer, W; Schueller, J1
Arra, C; Avallone, A; Bruzzese, F; Budillon, A; Chianese, MI; de Ruggiero, I; Di Cintio, A; Di Gennaro, E; Franco, R; Luciano, A; Moccia, T; Piro, G1
Gao, MQ; Huang, AM; Zhuo, LJ1
Ait-Tihyaty, M; Jean-Claude, BJ; Mihalcioiu, C; Rachid, Z1
Bellot, GL; Koh, D; Tan, WH; Tay, LL; Wang, X1
Hasegawa, K; Kato, R; Kawamura, K; Kobayashi, Y; Okamoto, H; Sekiya, T; Udagawa, Y1
Harada, N; Kurasawa, M; Mori, K; Sato, Y; Yanagisawa, M; Yasuno, H1
Albain, KS; Blanke, CD; Coleman, D; Ely, B; Gold, PJ; Gotay, C; Lenz, HJ; Louie, SG; Raghavan, D; Shields, AF1
Cass, CE; Damaraju, VL; Kuzma, M; Mowles, D; Sawyer, MB; Wilson, M1
Czejka, M; Dittrich, C; Gintersdorfer, S; Kitzmueller, M; Lichtneckert, M; Neudorfer, C; Poxhofer, M; Schreiber, V1
Buchner, P; Czejka, M; Farkouh, A; Georgopoulos, A; Gruenberger, B; Scheithauer, W; Schueller, J1
Chen, Q; Li, H; Lin, JM; Wu, J; Zhang, J1
Chen, X; Dai, X; Deng, P; Ding, L; Ji, C; Zhong, D1
Baken, BC; Erlinghagen, V; Fuhr, U; Kubeš, V; Novotný, V; Peroutka, R; Queckenberg, C; Van Os, SH; Wargenau, M1
Ding, W; Ji, M; Jiang, J; Li, X; Lu, Q; Qiang, W; Shi, L; Wu, C; Wu, J; Zhao, J1
Hwang, SH; Kim, SG1
Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y1
Ito, Y; Kobuchi, S; Sakaeda, T; Yazaki, Y1
Fujita, KI; Ishida, H; Ishikawa, F; Kubota, Y; Ohkuma, R; Sasaki, Y; Sekido, M; Shibanuma, M; Takahashi, T; Tsunoda, T1
Beijnen, JH; Cats, A; de Vries, N; Deenen, MJ; Huitema, ADR; Jacobs, BAW; Joerger, M; Meulendijks, D; Rosing, H; Schellens, JHM1
Bao, L; Chen, Z; He, H; Huang, Y; Li, P; Xiao, G; Xu, L; Yang, R; Zhang, Y1
Beijnen, JH; Derissen, EJ; Huitema, AD; Jacobs, BA; Rosing, H; Schellens, JH1

Reviews

7 review(s) available for capecitabine and floxuridine

ArticleYear
[Oral fluoropyrimidines in oncology].
    Anales de la Real Academia Nacional de Medicina, 1998, Volume: 115, Issue:3

    Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil

1998
[New drugs in gastrointestinal oncology. Current status and future directions].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine

1999
[Doxifluridine for treatment of colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Pentosyltransferases; Prodrugs; Prognosis; Pyrimidine Phosphorylases; Thymidine Phosphorylase

2003
Uridine phosphorylase in breast cancer: a new prognostic factor?
    Frontiers in bioscience : a journal and virtual library, 2006, Sep-01, Volume: 11

    Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Induction; Female; Floxuridine; Fluorouracil; Gene Expression Regulation; Humans; Mice; Prodrugs; Prognosis; Pyrimidinones; Treatment Outcome; Uridine Phosphorylase

2006
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis

2008
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
    The oncologist, 2010, Volume: 15, Issue:1

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil

2010
Oral versus intravenous fluoropyrimidines for colorectal cancer.
    The Cochrane database of systematic reviews, 2017, Jul-28, Volume: 7

    Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil

2017

Trials

10 trial(s) available for capecitabine and floxuridine

ArticleYear
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
    British journal of clinical pharmacology, 2003, Volume: 55, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged

2003
Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine (5'-DFUR).
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Middle Aged

2005
Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer.
    Journal of pharmacokinetics and pharmacodynamics, 2005, Volume: 32, Issue:5-6

    Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Irinotecan; Middle Aged; Models, Biological; Molecular Structure; Neoplasm Metastasis; Neoplasms; Prodrugs; Sesquiterpenes

2005
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis

2008
A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors.
    Anti-cancer drugs, 2008, Volume: 19, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cohort Studies; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Indoles; Male; Middle Aged; Monocytes; Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C beta

2008
Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Feb-10, Volume: 28, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Catheter Ablation; Chemotherapy, Adjuvant; Colorectal Neoplasms; Cryosurgery; Deoxycytidine; Dexamethasone; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Proportional Hazards Models; Risk Assessment; Time Factors; Treatment Outcome; United States

2010
Plasma disposition of capecitabine and its metabolites 5'DFCR and 5'DFUR in a standard and dose-intensified monotherapy regimen.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Cross-Over Studies; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged

2011
Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
    British journal of cancer, 2013, Oct-01, Volume: 109, Issue:7

    Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors

2013
Simultaneous determination of capecitabine and its three nucleoside metabolites in human plasma by high performance liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, May-01, Volume: 989

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Male; Neoplasms; Tandem Mass Spectrometry; Therapeutic Equivalency

2015
Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:5

    Topics: Activation, Metabolic; Administration, Oral; Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carboxylesterase; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Genotype; Humans; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prodrugs; Tablets; Therapeutic Equivalency; Thymidine Phosphorylase; Thymidylate Synthase

2015

Other Studies

47 other study(ies) available for capecitabine and floxuridine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.
    Cancer research, 1998, Feb-15, Volume: 58, Issue:4

    Topics: Animals; Antineoplastic Agents; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Oxidoreductases; Thymidine Phosphorylase

1998
Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine).
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:7

    Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Pyrimidines; Subrenal Capsule Assay

1998
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
    European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:8

    Topics: Animals; Capecitabine; Carboxylic Ester Hydrolases; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Liver; Male; Mice; Neoplasms; Thymidine Phosphorylase

1998
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
    International journal of cancer, 1999, Sep-24, Volume: 83, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Capecitabine; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Thymidine Phosphorylase; Time Factors; Up-Regulation

1999
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Capecitabine; Carbamates; Carboxylic Ester Hydrolases; Deoxycytidine; Drug Delivery Systems; Floxuridine; Fluorouracil; Humans; Intestines; Kinetics; Liver; Macaca fascicularis; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Structure-Activity Relationship; Substrate Specificity; Transplantation, Heterologous

2000
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
    International journal of cancer, 2001, May-01, Volume: 92, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA, Complementary; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease Models, Animal; Docetaxel; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Paclitaxel; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation; Xenograft Model Antitumor Assays

2001
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.
    Molecular pharmacology, 2001, Volume: 59, Issue:6

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Capecitabine; Carrier Proteins; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Deoxycytidine; DNA, Complementary; Drug Screening Assays, Antitumor; Fetus; Floxuridine; Fluorouracil; Humans; Liver; Membrane Transport Proteins; Oocytes; Prodrugs; Transfection; Xenopus laevis

2001
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:1

    Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Antibody Formation; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Membrane Transport Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Thioinosine

2002
Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer.
    International journal of clinical pharmacology and therapeutics, 2002, Volume: 40, Issue:12

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Electrophoresis, Capillary; Extracellular Space; Floxuridine; Fluorouracil; Humans; Prodrugs; Skin Neoplasms; Tissue Distribution

2002
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Primers; Floxuridine; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Models, Chemical; Polymerase Chain Reaction; Pyrimidines; Quinazolines; RNA; RNA, Messenger; Time Factors; Transcription, Genetic

2003
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
    Cancer research, 2003, Nov-15, Volume: 63, Issue:22

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs

2003
Cytotoxic chemotherapy for metastatic renal cell carcinoma.
    Der Urologe. Ausg. A, 2004, Volume: 43 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Renal Cell; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Humans; Kidney Neoplasms; Neoplasm Metastasis; Survival Rate

2004
Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:7

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Cytosol; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Prodrugs; Pyridines; Thymidine Phosphorylase

2004
[Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:13

    Topics: 5'-Nucleotidase; Adenocarcinoma, Scirrhous; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Survival Rate

2004
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
    Oncology reports, 2005, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays

2005
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
    Oncology reports, 2005, Volume: 14, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Time Factors; Transfection; Treatment Outcome

2005
[Experience with capecitabine in patients with anthracycline and/or taxane-resistant recurrent breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:8

    Topics: Administration, Oral; Anthracyclines; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Taxoids

2005
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Nov-05, Volume: 826, Issue:1-2

    Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Humans; Liver; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2005
[Pharmacokinetic comparison of capecitabine and 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:13

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Clinical Trials, Phase II as Topic; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Prodrugs

2005
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
    Journal of surgical oncology, 2006, Jan-01, Volume: 93, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Thymidine Phosphorylase; Up-Regulation

2006
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
    Molecular pharmacology, 2006, Volume: 69, Issue:4

    Topics: Animals; Base Sequence; Capecitabine; Deoxycytidine; DNA Primers; Drug Synergism; Electrophoretic Mobility Shift Assay; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Mice; NF-kappa B; Tumor Necrosis Factor-alpha; Uridine Phosphorylase

2006
Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
    The Journal of toxicological sciences, 2006, Volume: 31, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carbamates; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Macaca fascicularis; Male; Mice; Rats; Rats, Sprague-Dawley

2006
Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography.
    Journal of chromatography. A, 2007, Jan-05, Volume: 1138, Issue:1-2

    Topics: Animals; Bile; Calibration; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Mice; Plasma; Rabbits; Reproducibility of Results; Serum

2007
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
    British journal of cancer, 2007, Jan-15, Volume: 96, Issue:1

    Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays

2007
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Quality of Life; Skin Neoplasms; Tegafur; Toremifene

2007
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:4

    Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine

2010
Increased anticoagulant activity of warfarin used in combination with doxifluridine.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:5

    Topics: Administration, Oral; Aged; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; International Normalized Ratio; Warfarin

2010
Plasma disposition of capecitabine (CCB) and its metabolites 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouracil (5'-DFUR) with two different capecitabine/oxaliplatin dosage regimens.
    International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin

2010
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
    British journal of cancer, 2010, Nov-23, Volume: 103, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Female; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Thymidine Phosphorylase; Thymidylate Synthase; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays

2010
[Improved sensitivity of gastric carcinoma cells to fluorouracil-related drugs by transfection of thymidine phosphorylase gene].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2011, Volume: 40, Issue:5

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Plasmids; Recombinant Proteins; RNA, Messenger; Sensitivity and Specificity; Stomach Neoplasms; Thymidine Phosphorylase; Transfection

2011
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda.
    Breast cancer research and treatment, 2012, Volume: 133, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Synergism; ErbB Receptors; Female; Floxuridine; Fluorouracil; Gefitinib; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Methotrexate; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Thymidine Phosphorylase; Thymidylate Synthase

2012
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
    Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil

2012
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
    European journal of obstetrics, gynecology, and reproductive biology, 2012, Volume: 163, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Ifosfamide; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Peplomycin; Thymidine Phosphorylase; Uterine Cervical Neoplasms

2012
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
    Oncology reports, 2013, Volume: 29, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Mice; Mice, Nude; Neoplasms; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Ribonucleotide Reductases; RNA, Messenger; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase

2013
Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2013, Volume: 91, Issue:6

    Topics: Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Capecitabine; Cell Line, Tumor; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Interferon-alpha; Kidney Tubules, Proximal; Kinetics; Nucleosides; Signal Transduction; Thymidine Phosphorylase

2013
Impact of co-administered drugs on drug monitoring of capecitabine in patients with advanced colorectal cancer.
    Anticancer research, 2014, Volume: 34, Issue:7

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Floxuridine; Fluorouracil; Humans; Pantoprazole; Proton Pump Inhibitors

2014
Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab.
    Anticancer research, 2014, Volume: 34, Issue:7

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged

2014
An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector.
    Biosensors & bioelectronics, 2015, Jun-15, Volume: 68

    Topics: Antimetabolites, Antineoplastic; Biosensing Techniques; Capecitabine; Cell Survival; Coculture Techniques; Equipment Design; Floxuridine; Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; MCF-7 Cells; Prodrugs; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization

2015
First-line treatment with hepatic arterial infusion plus capecitabine vs capecitabine alone for elderly patients with unresectable colorectal liver metastases.
    Cancer biology & therapy, 2016, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Capecitabine; Colorectal Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Neoplasm Metastasis

2016
The association between the duration of fluoropyrimidine-based adjuvant chemotherapy and survival in stage II or III gastric cancer.
    World journal of surgical oncology, 2016, Apr-02, Volume: 14

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Drug Combinations; Female; Floxuridine; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Time Factors; Uracil

2016
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Circadian Rhythm; Deoxycytidine; Floxuridine; Fluorouracil; Male; Prodrugs; Rats, Wistar

2018
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
    Cancer chemotherapy and pharmacology, 2019, Volume: 83, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cell Proliferation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Rabeprazole

2019
Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.
    CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:12

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Neoplasms; Pharmacogenomic Variants; Prodrugs

2019
Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides.
    Nature communications, 2020, 01-21, Volume: 11, Issue:1

    Topics: Benzoates; Biological Products; Capecitabine; Chemistry Techniques, Synthetic; Chemistry, Pharmaceutical; Floxuridine; Glycosides; Glycosylation; Molecular Structure; Nucleosides

2020
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
    British journal of clinical pharmacology, 2016, Volume: 81, Issue:5

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyuracil Nucleotides; Deoxyuridine; Fluorouracil; Humans; Leukocytes, Mononuclear; Neoplasms; Tandem Mass Spectrometry; Uridine Triphosphate

2016