Page last updated: 2024-08-16

canrenoic acid and spironolactone

canrenoic acid has been researched along with spironolactone in 95 studies

Research

Studies (95)

Timeframe	Studies, this research(%)	All Research%
pre-1990	69 (72.63)	18.7374
1990's	5 (5.26)	18.2507
2000's	9 (9.47)	29.6817
2010's	12 (12.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Karlmar, KE	1
Corvol, P; Freifeld, M; Mahoudeau, J; Menard, J; Michaud, A	1
Chisaka, E; Fukuma, M; Imamura, T; Kashiwagi, S; Sasaki, J	1
Bricaire, H; Corvol, P; Mahoudeau, JA; Ménard, J; Valcke, JC	1
Claire, M; Corvol, P; Menard, J; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C	1
Karim, A	1
Schröder, R	1
Buch, J; Waldorff, S	1
Corvol, P; Delarue, C; Jegou, S; Kusmierek, MC; Leboulenger, F; Leroux, P; Tonon, MC; Vaillant, R; Vaudry, H	1
Eandi, M; Miocchi, D; Ricci Gamalero, S	1
Jaeger, H; Rosenthal, J; Specker, M	1
Casals-Stenzel, J; Losert, W; Schmalbach, J	1
Lichey, J; Rietbrock, N; Schröder, R	2
Osswald, H	1
Abshagen, U; L'age, M; Spörl, S	1
Brass, B; Mertin, J; Simon, O	1
Balasubramanian, V; Boreham, DR; Brooks, CJ; Palmer, RF; Vose, CW	1
Kim, KS; Miyamori, I; Morimoto, S; Takeda, R; Uchida, K; Yamamoto, I	1
Hierholzer, K	1
Aupetit, B; Duchier, J; Legrand, JC	1
Berger, E; Cristodorescu, R; Deutsch, G; Gavrilescu, S	1
Antalóczy, Z; Harsányi, A; Préda, I; Sebeszta, M; Szabó, G	1
Asbury, M; Harrison, I; Ramsay, L; Shelton, J; Tidd, M	1
Auty, R; Branch, R; Levine, D; Ramsay, L; Tidd, M	1
Ramsay, LE; Shelton, JR; Tidd, MJ	1
Bräuninger, HJ; Gorbach, HC	1
Esch, I; Gaul, G; Placheta, P	1
Harrison, IR; Ramsay, LE; Shelton, JR; Tidd, MJ	1
Asbury, M; Harrison, I; Ramsay, L; Shelton, J	1
Caminos-Torres, R; Ma, L; Snyder, PJ	1
Breuer, H; Külpmann, WR; Spiegelhalder, B; Wilk, C	1
Koch, K; Neubert, P	1
Abshagen, U; Kuhlmann, J; Rennekamp, H	1
Auty, R; Branch, RA; Cole, EN; Levine, D; Ramsay, L	1
Cheng, SC; Harding, BW; Sadee, W; Suzuki, K	1
Harrison, I; Ramsay, L; Shelton, J; Tidd, M	1
Baethmann, A; Finn, AM; Sadée, W; Schmiedek, P	1
Chinn, LJ; Hofmann, LM; Krupnick, MI; Pedrera, HA; Suleymanov, OD	1
Knauf, H	1
Aricó, M; Bongiorno, MR; Bosco, M; Noto, G; Pravatá, G	1
Gentilini, P	1
Zaun, H	1
Andriulli, A; Armanini, D; Arrigoni, A; Buzzetti, G; Gindro, T; Karbowiak, I	1
Dupont, A	1
Bellati, G; Idéo, G	1
Cuppone, R; Emili, M; Ricci, GL	1
Ozaki, N; Suzuki, S; Takamura, S; Yoshida, J	1
Andriulli, A; Arrigoni, A; Gindro, T; Verme, G	1
Aksamit, W; Bible, RH; Cook, CS; Finnegan, P; Hauswald, CL; Hribar, JD; Patel, A; Piper, CE; Radzialowski, FM; Schoenhard, GL	1
Traina, M; Vizzini, GB	1
Boer, P; Dorhout Mees, EJ; Hené, RJ; Koomans, HA	1
Barone, M; Di Leo, A; Eagon, PK; Fanizza, G; Francavilla, A; Guglielmi, F; Polimeno, L; Starzl, TE	1
Lant, A	1
Fujioka, H; Kaneko, H; Kojima, K; Yamamoto, K	1
Buse, M; Casals-Stenzel, J; Losert, W	2
Armanini, D; Funder, JW; Goi, A; Karbowiak, I; Mantero, F	1
Nagy, O; Radó, JP; Szende, L; Takó, J	1
Colombo Pirola, L; Russo, R; Schena, FP	1
Jacobelli, A	1
Finotti, P; Palatini, P	1
Antalóczy, Z; Préda, I; Sebeszta, M	1
Fanti, P; Mantellini, R; Sciarra, F; Tosti-Croce, C	1
Denis, B; Dimitriou, R; Machecourt, J; Page, E; Reboud, JP; Wolf, JE	1
Kato, R; Kubota, K; Muraki, T; Nakadate, T; Tokunaga, Y	1
Kuntz, E	1
Rahn, KH	1
Claire, M; Corvol, P; Geering, K; Oblin, ME; Rossier, B	1
Liebich, HG; Mertin, J; Seifert, J	1
Haschke, F; Parth, K; Wimmer, M	1
Claire, M; Corvol, P; Fournex, R; Michaud, A; Peterfalvi, M; Rousseau, G; Torelli, V	1
Cook, CS; Hauswald, C; Oppermann, JA; Schoenhard, GL	1
Andriuoli, G; Calignano, A; Cirino, G; Mancuso, F; Pinto, A; Sorrentino, L; Sorrentino, R	1
Alfieri, C; Autore, G; Calignano, A; Cirino, G; d'Emmanuele de Villa Bianca, R; Pinto, A; Sorrentino, L; Sorrentino, R; Vanasia, M	1
Dasgupta, A; Datta, P; Saffer, H; Wells, A	1
Arias, C; Caballero, R; Delpón, E; González, T; Moreno, I; Tamargo, J; Valenzuela, C	1
Dasgupta, A; Datta, P	1
Bendtzen, K; Hansen, PR; Rieneck, K	1
Caballero, R; Delpón, E; Gómez, R; Núñez, L; Tamargo, J; Vaquero, M	1
Arvat, E; Balbo, M; Baldi, M; Bo, M; Bonelli, L; Ghigo, E; Giordano, R; Migliaretti, G; Pellegrino, M; Picu, A; Vezzari, M	1
MacDonald, TM; Parthasarathy, HK	1
Dasgupta, A; Tso, G; Wells, A	1
Drogies, T; Felix, SB; Ghaleh, B; Krieg, T; Schmidt, K; Tissier, R	1
Bowalgaha, K; Knights, KM; Miners, JO	1
Ginès, P	1
Armbruster, D; Cooper, KC; Dasgupta, A; DeFrance, A; Petty, D	1
Dasgupta, A; Johnson, MJ	1
Dasgupta, A; Johnson, MJ; Sengupta, TK	1
Coppi, F; Crupi, N; Monopoli, D; Rossi, R; Sgura, F	1
Belle, L; Beygui, F; Cayla, G; Collet, JP; Cornillet, L; Delarche, N; Ecollan, P; Furber, A; Galinier, M; Goldstein, P; Lebon, A; Legallois, D; Machecourt, J; Montalescot, G; Motreff, P; Roubille, F; Roule, V; Rousseau, H; Silvain, J; Van Belle, E; Vicaut, E; Zannad, F	1
Behar-Cohen, F; Berdugo, M; Bravo-Osuna, I; El Zaoui, I; Gurny, R; Herrero-Vanrell, R; Kaufmann, B; Kowalczuk, L; Le Normand, M; Levy-Boukris, R; Molina-Martínez, IT; Rodríguez-Villagra, E; Zhao, M	1
Behar-Cohen, F; Bertaim, T; Dahmana, N; Gabriel, D; Gurny, R; Kalia, YN; Kaltsatos, V; Mugnier, T	1
Beygui, F; Ecollan, P; Flather, M; Hamm, CW; Lopez De Sa, E; Machecourt, J; Montalescot, G; Pitt, B; Van Belle, E; Verheugt, FWA; Vicaut, E; Zannad, F	1
Blackman, D; Bulluck, H; Davies, J; Fröhlich, GM; Gamma, R; Garg, P; Greenwood, JP; Hausenloy, DJ; Mathur, A; Mohdnazri, S; Moon, JC; Nicholas, JM; Sirker, A	1

Reviews

6 review(s) available for canrenoic acid and spironolactone

Article	Year
Spirolactones: clinical and pharmacologic studies. Advances in nephrology from the Necker Hospital, 1977, Volume: 7 Topics: Aldosterone; Animals; Binding, Competitive; Canrenoic Acid; Canrenone; Diuresis; Humans; Hyperaldosteronism; Hypertension; In Vitro Techniques; Kidney; Mineralocorticoid Receptor Antagonists; Pregnadienes; Protein Binding; Rats; Receptors, Cell Surface; Spironolactone	1977
Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug metabolism reviews, 1978, Volume: 8, Issue:1 Topics: Animals; Biological Availability; Biotransformation; Canrenoic Acid; Drug Combinations; Erythrocytes; Food; Half-Life; Humans; Hydrochlorothiazide; Kinetics; Milk, Human; Protein Binding; Species Specificity; Spironolactone; Tissue Distribution	1978
Diuretics. Clinical pharmacology and therapeutic use (Part II). Drugs, 1985, Volume: 29, Issue:2 Topics: Amiloride; Canrenoic Acid; Diuretics; Diuretics, Osmotic; Drug Interactions; Hearing Disorders; Heart Failure; Humans; Hypertension; Hypokalemia; Indans; Kidney Failure, Chronic; Liver Diseases; Potassium; Pulmonary Edema; Spironolactone; Ticrynafen; Triamterene; Uricosuric Agents; Water-Electrolyte Imbalance; Xanthines	1985
Mechanism of the antimineralocorticoid effects of spirolactones. Kidney international, 1981, Volume: 20, Issue:1 Topics: Aldosterone; Animals; Anura; Canrenoic Acid; Canrenone; Cattle; Guinea Pigs; Humans; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Steroid; Spironolactone; Veratrum Alkaloids	1981
Mineralocorticoid receptor antagonists. Current hypertension reports, 2007, Volume: 9, Issue:1 Topics: Animals; Canrenoic Acid; Cardiovascular Diseases; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone	2007
Individual participant data analysis of two trials on aldosterone blockade in myocardial infarction. Heart (British Cardiac Society), 2018, Volume: 104, Issue:22 Topics: Aged; Canrenoic Acid; Eplerenone; Equivalence Trials as Topic; Female; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Multicenter Studies as Topic; Risk Factors; Spironolactone; ST Elevation Myocardial Infarction; Time Factors; Treatment Outcome	2018

Trials

16 trial(s) available for canrenoic acid and spironolactone

Article	Year
Spironolactone and potassium canrenoate in normal man. Clinical pharmacology and therapeutics, 1976, Volume: 20, Issue:2 Topics: Canrenoic Acid; Canrenone; Clinical Trials as Topic; Humans; Male; Potassium; Pregnadienes; Sodium; Spironolactone; Time Factors	1976
Antagonism of endogenous mineralocorticoids in normal subjects by prorenoate potassium and spironolactone. European journal of clinical pharmacology, 1976, Mar-22, Volume: 09, Issue:5-6 Topics: Adult; Canrenoic Acid; Clinical Trials as Topic; Diuresis; Furosemide; Humans; Male; Mineralocorticoid Receptor Antagonists; Placebos; Potassium; Pregnadienes; Pregnenes; Sodium; Spironolactone	1976
The pharmacodynamics of single doses of prorenoate potasssium and spironolactone in fludrocortisone treated normal subjects. British journal of clinical pharmacology, 1976, Volume: 3, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Canrenoic Acid; Clinical Trials as Topic; Diuresis; Fludrocortisone; Humans; Male; Potassium; Pregnadienes; Sodium; Spironolactone; Time Factors	1976
[Plasma renin activity in essential hypertension: different short- und long-term effects of diuretics (author's transl)]. Wiener klinische Wochenschrift, 1976, Jun-25, Volume: 88, Issue:13 Topics: Adult; Amiloride; Canrenoic Acid; Chlorthalidone; Clinical Trials as Topic; Diuresis; Diuretics; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged; Renin; Spironolactone; Time Factors	1976
Relative potency of prorenoate and spironolactone in normal man. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:4 Topics: Adolescent; Adult; Canrenoic Acid; Clinical Trials as Topic; Creatinine; Dose-Response Relationship, Drug; Fludrocortisone; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Pregnadienes; Sodium; Spironolactone	1975
Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy. Digestion, 1989, Volume: 44, Issue:3 Topics: Adult; Aged; Ascites; Canrenoic Acid; Canrenone; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Pregnadienes; Random Allocation; Receptors, Androgen; Recurrence; Spironolactone; Testosterone; Time Factors	1989
Gynaecomastia after spironolactone and potassium canrenoate. Lancet (London, England), 1986, Mar-15, Volume: 1, Issue:8481 Topics: Ascites; Canrenoic Acid; Gynecomastia; Humans; Liver Cirrhosis; Male; Pregnadienes; Prospective Studies; Spironolactone	1986
Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-over. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Aldosterone; Canrenoic Acid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperaldosteronism; Liver Cirrhosis; Liver Function Tests; Male; Pregnadienes; Random Allocation; Spironolactone	1988
The use of diuretics in preventing ascites recurrence. The British journal of clinical practice, 1988, Volume: 42, Issue:3 Topics: Adult; Aged; Ascites; Canrenoic Acid; Follow-Up Studies; Humans; Liver Cirrhosis; Male; Middle Aged; Pregnadienes; Recurrence; Spironolactone	1988
[Controlled study of the effect of long-term administration of canrenoate potassium in cirrhotic ascites]. Minerva medica, 1986, Jan-28, Volume: 77, Issue:3-4 Topics: Adult; Aged; Ascites; Canrenoic Acid; Clinical Trials as Topic; Drug Evaluation; Female; Gynecomastia; Humans; Liver Cirrhosis; Male; Middle Aged; Pregnadienes; Spironolactone	1986
[Controlled clinical study on 2 antialdosterone diuretics in the nephrotic syndrome]. La Clinica terapeutica, 1984, Apr-15, Volume: 109, Issue:1 Topics: Adolescent; Adult; Aged; Blood Pressure; Body Weight; Canrenoic Acid; Clinical Trials as Topic; Diuresis; Female; Humans; Male; Middle Aged; Nephrotic Syndrome; Pregnadienes; Spironolactone	1984
[Clinical study of the efficacy of oral potassium canrenoate and spironolactone in essential arterial hypertension]. Minerva medica, 1983, Apr-07, Volume: 74, Issue:14-15 Topics: Administration, Oral; Adult; Aldosterone; Blood Pressure; Canrenoic Acid; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pregnadienes; Renin; Spironolactone; Time Factors	1983
[Hyperaldosteronism in the acute phase of myocardial infarction. Effects of its treatment on the prevention of ventricular fibrillation]. Archives des maladies du coeur et des vaisseaux, 1984, Volume: 77 Spec No Topics: Acute Disease; Adult; Aged; Anti-Arrhythmia Agents; Canrenoic Acid; Clinical Trials as Topic; Female; Heparin; Humans; Hyperaldosteronism; Male; Middle Aged; Myocardial Infarction; Pregnadienes; Spironolactone; Ventricular Fibrillation	1984
Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:10 Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Canrenoic Acid; Circadian Rhythm; Dehydroepiandrosterone; Drug Resistance; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mineralocorticoid Receptor Antagonists; Pituitary-Adrenal System; Spironolactone; Stimulation, Chemical	2005
Early Aldosterone Blockade in Acute Myocardial Infarction: The ALBATROSS Randomized Clinical Trial. Journal of the American College of Cardiology, 2016, Apr-26, Volume: 67, Issue:16 Topics: Age Factors; Aged; Canrenoic Acid; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Proportional Hazards Models; Risk Assessment; Severity of Illness Index; Sex Factors; Single-Blind Method; Spironolactone; Statistics, Nonparametric; Survival Analysis; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left	2016
Mineralocorticoid receptor antagonist pre-treatment and early post-treatment to minimize reperfusion injury after ST-elevation myocardial infarction: The MINIMIZE STEMI trial. American heart journal, 2019, Volume: 211 Topics: Aged; Canrenoic Acid; Cardiac Imaging Techniques; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Reperfusion Injury; Percutaneous Coronary Intervention; Pilot Projects; Proof of Concept Study; Spironolactone; ST Elevation Myocardial Infarction; Ventricular Remodeling	2019

Other Studies

73 other study(ies) available for canrenoic acid and spironolactone

Article	Year
Assay and properties of 18-hydroxylation of endogenous and exogenous corticosterone in rat adrenals. Evidence for heterogeneity of 18-hydroxylase activity. Journal of lipid research, 1979, Volume: 20, Issue:6 Topics: Adrenal Glands; Animals; Canrenoic Acid; Canrenone; Corticosterone; Gas Chromatography-Mass Spectrometry; Male; Mitochondria; NADPH-Ferrihemoprotein Reductase; Potassium Chloride; Rats; Spironolactone; Steroid Hydroxylases	1979
Antiandrogenic effect of spirolactones: mechanism of action. Endocrinology, 1975, Volume: 97, Issue:1 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Binding, Competitive; Canrenoic Acid; Cell Nucleus; Cyproterone; Cytosol; Dihydrotestosterone; Hyperaldosteronism; Hypertension; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone; Tritium	1975
[A case of primary aldosteronism associated with spironolactone inclusions (author's transl)]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1975, Jun-10, Volume: 64, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Canrenoic Acid; Female; Humans; Hyperaldosteronism; Inclusion Bodies; Paranoid Disorders; Spironolactone	1975
[Sexual side-effects of spironolactones. Possible mechanisms of their anti-androgen action]. La Nouvelle presse medicale, 1976, Mar-13, Volume: 5, Issue:11 Topics: Adult; Animals; Canrenoic Acid; Cytosol; Depression, Chemical; Dihydrotestosterone; Follicle Stimulating Hormone; Gynecomastia; Humans; Hydroxysteroid Dehydrogenases; Luteinizing Hormone; Male; Pregnadienes; Prostate; Rats; Receptors, Cell Surface; Spironolactone; Testosterone; Tritium	1976
[New aspects of treatment of hemodynamic complications in acute myocardial infarction (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:3a Topics: Animals; Canrenoic Acid; Digitalis Glycosides; Dogs; Dopamine; Furosemide; Hemodynamics; Humans; Myocardial Infarction; Nitroglycerin; Phentolamine; Shock, Cardiogenic; Spironolactone	1977
Canrenoate--a spironolactone metabolite. Acute cardiac effects in digitalized patients. European journal of cardiology, 1979, Volume: 10, Issue:2 Topics: Aged; Canrenoic Acid; Digitalis Glycosides; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction; Pregnadienes; Spironolactone; Stimulation, Chemical; Systole	1979
Comparative effects of canrenoate-K and prorenoate-K upon aldosterone biosynthesis in perifused frog interrenal glands. Steroids, 1979, Volume: 34, Issue:3 Topics: Adrenal Glands; Aldosterone; Animals; Anura; Canrenoic Acid; Interrenal Gland; Mineralocorticoid Receptor Antagonists; Pregnadienes; Radioimmunoassay; Ranidae; Spironolactone; Time Factors	1979
Response to nor-epinephrine, isoprenaline and spironolactone derivatives in normal and hypertensive rats. Bollettino della Societa italiana di biologia sperimentale, 1979, Jul-15, Volume: 55, Issue:13 Topics: Animals; Blood Pressure; Canrenoic Acid; Heart Rate; Hypertension, Renal; Isoproterenol; Norepinephrine; Rats; Spironolactone; Time Factors	1979
[Comparative study of relative biovailability of several spironolactone formulations in a steady-state test (author's transl)]. Arzneimittel-Forschung, 1979, Volume: 29, Issue:9 Topics: Adult; Biological Availability; Canrenoic Acid; Canrenone; Female; Humans; Male; Spironolactone; Time Factors	1979
Improved method for comparative evaluation of aldosterone antagonists in healthy man. European journal of clinical pharmacology, 1977, Dec-02, Volume: 12, Issue:4 Topics: Adult; Aldosterone; Canrenoic Acid; Drug Evaluation; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Time Factors	1977
The effect of oral spironolactone and intravenous canrenoate-K on the digoxin radioimmunoassay. International journal of clinical pharmacology and biopharmacy, 1977, Volume: 15, Issue:12 Topics: Canrenoic Acid; Digoxin; Drug Interactions; Humans; Pregnadienes; Radioimmunoassay; Spironolactone; Time Factors	1977
[Aldosterone antagonists in coronary insufficiency]. Medizinische Klinik, 1978, Jan-20, Volume: 73, Issue:3 Topics: Arrhythmias, Cardiac; Canrenoic Acid; Heart Failure; Humans; Myocardial Contraction; Myocardial Infarction; Pregnadienes; Spironolactone; Stimulation, Chemical	1978
Non-interaction of spironolactone medication and cortisol metabolism in man. Klinische Wochenschrift, 1978, Feb-01, Volume: 56, Issue:3 Topics: Canrenoic Acid; Canrenone; Drug Interactions; Humans; Hydrocortisone; Liver Diseases; Spironolactone	1978
[EEG changes following spirolactone treatment (author's transl)]. Medizinische Klinik, 1978, Mar-31, Volume: 73, Issue:13 Topics: Aldosterone; Brain Edema; Canrenoic Acid; Electroencephalography; Encephalitis; Female; Humans; Male; Multiple Sclerosis; Spironolactone	1978
Application of ion-exchange and lipophilic-gel chromatography to the purification and group fractionation of steroidal spirolactones, isolated from biological fluids. Journal of chromatography, 1978, Jun-01, Volume: 153, Issue:1 Topics: Canrenoic Acid; Chromatography, Gel; Chromatography, Ion Exchange; Humans; Spironolactone	1978
[Measurement of plasma aldosterone by 125I-aldosterone radioimmunoassay kit (author's transl)]. Radioisotopes, 1978, Volume: 27, Issue:6 Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Humans; Radioimmunoassay; Rats; Reagent Kits, Diagnostic; Spironolactone	1978
Modes of action of diuretics. Contributions to nephrology, 1978, Volume: 14 Topics: Acetazolamide; Amiloride; Animals; Benzothiadiazines; Biological Transport; Canrenoic Acid; Chlorides; Diuresis; Diuretics; Furosemide; Kidney Tubules; Mannitol; Potassium; Rats; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene	1978
[Effect of spironolactones on aldosterone synthesis and adrenal metabolism]. Annales d'endocrinologie, 1978, Volume: 39, Issue:5 Topics: Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Ducks; Hydroxylation; Mineralocorticoid Receptor Antagonists; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Sheep; Spironolactone; Steroid Hydroxylases	1978
Plasma digoxin radioimmunoassay in patients treated with potassium canrenoate and spironolactone. A comparison of two commerical kits. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1978, Volume: 19, Issue:6 Topics: Adult; Aged; Canrenoic Acid; Digoxin; Female; Humans; Male; Middle Aged; Pregnadienes; Radioimmunoassay; Reagent Kits, Diagnostic; Spironolactone	1978
The role of potassium-canrenoate on 3H-noradrenaline uptake and metabolism of the rat heart. Acta physiologica Academiae Scientiarum Hungaricae, 1978, Volume: 51, Issue:4 Topics: Animals; Canrenoic Acid; Hypokalemia; Myocardial Contraction; Myocardium; Norepinephrine; Pargyline; Pregnadienes; Rats; Spironolactone; Stimulation, Chemical; Tritium	1978
[Clinical experience in the use of Osyrol 100 and Osyrol for injection (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Volume: 117, Issue:37 Topics: Administration, Oral; Aged; Blood Pressure; Body Weight; Canrenoic Acid; Female; Heart Failure; Humans; Hyperaldosteronism; Injections; Liver Cirrhosis; Male; Natriuresis; Potassium; Pregnadienes; Sodium; Spironolactone	1975
Paradoxical potassium excretion in response to aldosterone antagonists. European journal of clinical pharmacology, 1977, Jan-03, Volume: 11, Issue:2 Topics: Adult; Canrenoic Acid; Diet; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Time Factors	1977
Spironolactone and canrenoate-K: relative potency at steady state. Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:5 Topics: Administration, Oral; Adult; Canrenoic Acid; Canrenone; Dose-Response Relationship, Drug; Fludrocortisone; Humans; Male; Potassium; Pregnadienes; Sodium; Solutions; Spironolactone; Tablets; Therapeutic Equivalency; Time Factors	1977
Gynecomastia and semen abnormalities induced by spironolactone in normal men. The Journal of clinical endocrinology and metabolism, 1977, Volume: 45, Issue:2 Topics: Adult; Canrenoic Acid; Canrenone; Estradiol; Follicle Stimulating Hormone; Gynecomastia; Humans; Luteinizing Hormone; Male; Pituitary Gland; Sperm Motility; Spermatozoa; Spironolactone; Testis; Testosterone	1977
[Plasma-digoxin concentration in patients at time of hospital admission (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1977, Jul-22, Volume: 102, Issue:29 Topics: Ambulatory Care; Canrenoic Acid; Creatinine; Digitalis Glycosides; Digoxin; Female; Hospitalization; Humans; Male; Radioimmunoassay; Spironolactone	1977
[Effect of spirolactones on the urinary excretion of individual 17-oxosteroids and of pregnanediol in man (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1977, Volume: 15, Issue:7 Topics: 17-Ketosteroids; Adult; Canrenoic Acid; Female; Humans; Male; Pregnadienes; Pregnancy; Pregnanediol; Sex Factors; Spironolactone	1977
Simultaneous automated determination of spironolactone metabolites in serum. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:8 Topics: Autoanalysis; Canrenoic Acid; Canrenone; Humans; Methods; Spectrometry, Fluorescence; Spironolactone; Time Factors	1977
Effects of pretreatment with spironolactone of pharmacokinetics of 4'''-methyldigoxin in man. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:1 Topics: Administration, Oral; Adult; Bile; Canrenoic Acid; Canrenone; Digoxin; Feces; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Spironolactone; Tritium	1976
Prolactin, diuretics and urinary electrolytes in normal subjects. The Journal of endocrinology, 1976, Volume: 70, Issue:2 Topics: Adult; Canrenoic Acid; Circadian Rhythm; Furosemide; Humans; Male; Potassium; Prolactin; Sodium; Spironolactone; Time Factors	1976
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinology, 1976, Volume: 99, Issue:4 Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Cattle; Cytochrome P-450 Enzyme System; Humans; Hyperplasia; Mitochondria; Oxidation-Reduction; Pregnadienes; Spectrum Analysis; Spironolactone; Steroid Hydroxylases	1976
Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite. Steroids, 1975, Volume: 25, Issue:3 Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Dogs; Humans; Mass Spectrometry; Pregnadienes; Rabbits; Radioimmunoassay; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spironolactone; Time Factors	1975
Potassium prorenoate: a new steroidal aldosterone antagonist. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:2 Topics: Adrenal Glands; Adrenalectomy; Animals; Canrenoic Acid; Desoxycorticosterone; Diuretics; Dogs; Female; Kidney; Kidney Function Tests; Male; Mineralocorticoid Receptor Antagonists; Potassium; Pregnadienes; Rats; Sodium; Spironolactone	1975
The effect of spironolactone on transport of Na+, K+ and H+. A microperfusion study in rat main submaxillary duct. European journal of clinical investigation, 1976, Jan-30, Volume: 6, Issue:1 Topics: Animals; Bicarbonates; Biological Transport, Active; Canrenoic Acid; Male; Potassium; Rats; Sodium; Spironolactone; Submandibular Gland	1976
Topical canrenoic acid. Quantification of the antiandrogenic activity in the hamster flank organ. International journal of dermatology, 1991, Volume: 30, Issue:11 Topics: Administration, Topical; Androgen Antagonists; Animals; Canrenoic Acid; Cricetinae; Female; Mesocricetus; Sebaceous Glands; Spironolactone	1991
Spironolactone and canrenoate: different antialdosteronic diuretic agents. Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:5 Topics: Ascites; Canrenoic Acid; Canrenone; Humans; Liver Cirrhosis; Recurrence; Spironolactone	1991
[Action of spironolactone and potassium canrenoate]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1990, Volume: 41, Issue:12 Topics: Canrenoic Acid; Hair; Humans; Spironolactone	1990
Disappearance of spironolactone-induced gynaecomastia during treatment with potassium canrenoate. Lancet (London, England), 1985, Sep-28, Volume: 2, Issue:8457 Topics: Canrenoic Acid; Gynecomastia; Humans; Hyperaldosteronism; Male; Middle Aged; Pregnadienes; Spironolactone	1985
Effect of aldosterone antagonists on aldosterone-induced activation of Mg2+ -HCO3- -ATPase and carbonic anhydrase in rat intestinal mucosa. Journal of steroid biochemistry, 1985, Volume: 23, Issue:1 Topics: Adenosine Triphosphatases; Adrenalectomy; Aldosterone; Animals; Ca(2+) Mg(2+)-ATPase; Canrenoic Acid; Carbonic Anhydrases; Dactinomycin; Duodenum; Enzyme Activation; Intestinal Mucosa; Jejunum; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone	1985
Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate. Archives of toxicology, 1988, Volume: 61, Issue:3 Topics: Animals; Bile; Canrenoic Acid; Feces; Glutathione; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Pregnadienes; Rats; Spironolactone	1988
Adaptation to chronic potassium loading in normal man. Mineral and electrolyte metabolism, 1986, Volume: 12, Issue:3 Topics: Acetazolamide; Adaptation, Biological; Administration, Oral; Adult; Aldosterone; Body Weight; Canrenoic Acid; Humans; Infusions, Parenteral; Injections, Intravenous; Kidney Tubules; Male; Potassium; Renin; Spironolactone; Time Factors	1986
Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver. Gastroenterology, 1987, Volume: 93, Issue:4 Topics: Animals; Canrenoic Acid; Carrier Proteins; Cell Nucleus; Cytosol; Hormones; Liver; Male; Pregnadienes; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Estrogen; Spironolactone	1987
Pharmacokinetics of spironolactone and potassium canrenoate in humans. Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:3 Topics: Adult; Canrenoic Acid; Chromatography, High Pressure Liquid; Glucuronates; Humans; Kinetics; Male; Middle Aged; Pregnadienes; Spectrometry, Fluorescence; Spironolactone	1985
Progestogens with antimineralocorticoid activity. Arzneimittel-Forschung, 1985, Volume: 35, Issue:2 Topics: Adrenalectomy; Aldosterone; Androstadienes; Androstenes; Animals; Canrenoic Acid; Canrenone; Cyproterone; Dose-Response Relationship, Drug; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Norethindrone; Norgestrel; Norpregnenes; Potassium; Progesterone; Progesterone Congeners; Rats; Rats, Inbred Strains; Sodium; Spironolactone	1985
In-vivo metabolites of spironolactone and potassium canrenoate: determination of potential anti-androgenic activity by a mouse kidney cytosol receptor assay. Clinical endocrinology, 1985, Volume: 23, Issue:4 Topics: Animals; Body Weight; Canrenoic Acid; Cytosol; Kidney; Male; Mice; Orchiectomy; Organ Size; Pregnadienes; Receptors, Androgen; Seminal Vesicles; Spironolactone; Testosterone	1985
Use of a simple fluorometric 11-hydroxycorticosteroids assay in the assessment of spironolactone-metabolite level in plasma and urine. Endokrinologie, 1974, Volume: 64, Issue:1 Topics: Canrenoic Acid; Canrenone; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Spironolactone; Time Factors	1974
[Treatment of hyperaldosteronism]. La Clinica terapeutica, 1984, Jun-30, Volume: 109, Issue:6 Topics: Adrenal Cortex Diseases; Canrenoic Acid; Female; Humans; Hyperaldosteronism; Male; Spironolactone	1984
Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:3 Topics: 4-Nitrophenylphosphatase; Animals; Canrenoic Acid; Canrenone; Guinea Pigs; In Vitro Techniques; Ouabain; Potassium; Pregnadienes; Protein Binding; Receptors, Drug; Sodium-Potassium-Exchanging ATPase; Spironolactone	1981
The effect of potassium canrenoate (Aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart. Advances in myocardiology, 1982, Volume: 3 Topics: Animals; Canrenoic Acid; Heart Atria; Heart Ventricles; Ion Channels; Muridae; Myocardial Contraction; Myocardium; Norepinephrine; Pargyline; Potassium; Pregnadienes; Spironolactone	1982
Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats. Experientia, 1980, Jun-15, Volume: 36, Issue:6 Topics: Androgen Antagonists; Animals; Canrenoic Acid; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Luteinizing Hormone; Male; Pregnadienes; Progesterone; Prolactin; Rats; Spironolactone; Testosterone	1980
[Disorders of water and electrolyte equilibrium in liver diseases. Part 3: therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1982, May-14, Volume: 124, Issue:19 Topics: Ascites; Benzothiadiazines; Canrenoic Acid; Diuretics; Humans; Hyperaldosteronism; Liver Diseases; Sodium Chloride Symporter Inhibitors; Spironolactone; Water-Electrolyte Imbalance	1982
Clinical pharmacology of diuretics. Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:2 Topics: Canrenoic Acid; Canrenone; Diuretics; Ethacrynic Acid; Humans; Hydrochlorothiazide; Intestinal Absorption; Kinetics; Protein Binding; Sodium Chloride Symporter Inhibitors; Spironolactone	1983
Detection and comparative evaluation of aldosterone antagonists in glucocorticoid-treated, adrenalectomized rats. European journal of pharmacology, 1982, May-07, Volume: 80, Issue:1 Topics: Adrenalectomy; Animals; Canrenoic Acid; Desoxycorticosterone; Dose-Response Relationship, Drug; Glucocorticoids; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone	1982
[Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical studies]. Fortschritte der Medizin, 1982, Nov-04, Volume: 100, Issue:41 Topics: Adult; Aldosterone; Animals; Canrenoic Acid; Female; Humans; Lymphocytes; Microscopy, Electron; Pregnadienes; Rats; Rats, Inbred Strains; Spironolactone	1982
Hyperaldosteronism after heart surgery in children. Part I: Treatment with aldosterone antagonists. Padiatrie und Padologie, 1981, Volume: 16, Issue:3 Topics: Adolescent; Aldosterone; Canrenoic Acid; Child; Child, Preschool; Heart Defects, Congenital; Hematocrit; Humans; Hyperaldosteronism; Infant; Mineralocorticoid Receptor Antagonists; Postoperative Complications; Potassium; Sodium; Spironolactone	1981
Importance of the lactonic ring in the activity of steroidal antialdosterones. Biochemical pharmacology, 1980, Volume: 29, Issue:3 Topics: Adrenalectomy; Animals; Canrenoic Acid; Canrenone; Chemical Phenomena; Chemistry; Lactones; Male; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone; Steroids	1980
Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Canrenoic Acid; Carbon Radioisotopes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epoxy Compounds; Erythromycin; Female; Glutathione; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains; Spironolactone; Sulfhydryl Compounds; Sulfur	1993
Increase in the basal tone of guinea pig thoracic aorta induced by ouabain is inhibited by spironolactone canrenone and potassium canrenoate. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4 Topics: Animals; Aorta, Thoracic; Canrenoic Acid; Canrenone; Cardiotonic Agents; Guinea Pigs; In Vitro Techniques; Isotonic Solutions; Muscle, Smooth, Vascular; Ouabain; Potassium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Vasoconstriction	1996
Effect of spironolactone and its metabolites on contractile property of isolated rat aorta rings. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:2 Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Canrenoic Acid; Canrenone; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Wistar; Spironolactone	2000
Bidirectional (positive/negative) interference of spironolactone, canrenone, and potassium canrenoate on serum digoxin measurement: elimination of interference by measuring free digoxin or using a chemiluminescent assay for digoxin. Journal of clinical laboratory analysis, 2002, Volume: 16, Issue:4 Topics: Canrenoic Acid; Canrenone; Cardiotonic Agents; Digoxin; Drug Interactions; Fluorescence Polarization Immunoassay; Humans; Luminescent Measurements; Mineralocorticoid Receptor Antagonists; Reproducibility of Results; Spironolactone	2002
Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels. Circulation, 2003, Feb-18, Volume: 107, Issue:6 Topics: Aldosterone; Animals; Canrenoic Acid; Cation Transport Proteins; CHO Cells; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electric Stimulation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Spironolactone; Trans-Activators; Transcriptional Regulator ERG; Transfection	2003
A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone. Therapeutic drug monitoring, 2003, Volume: 25, Issue:4 Topics: Canrenoic Acid; Canrenone; Cardiotonic Agents; Cross Reactions; Digoxin; Drug Interactions; Fluorescence Polarization Immunoassay; Humans; Spironolactone	2003
Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunology letters, 2004, Feb-15, Volume: 91, Issue:2-3 Topics: Aldosterone; Canrenoic Acid; Cells, Cultured; Cyproterone Acetate; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Leukocytes, Mononuclear; Lipopolysaccharides; Phytohemagglutinins; Pregnadienes; RNA, Messenger; Spironolactone; Transcription, Genetic	2004
Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels. British journal of pharmacology, 2005, Volume: 146, Issue:1 Topics: Animals; Canrenoic Acid; Cell Line; Fibroblasts; Guinea Pigs; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Potassium Channels, Voltage-Gated; Spironolactone	2005
Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay. Therapeutic drug monitoring, 2008, Volume: 30, Issue:6 Topics: Canrenoic Acid; Canrenone; Cross Reactions; Digoxin; Drug Interactions; Humans; Immunoassay; Mineralocorticoid Receptor Antagonists; Spironolactone	2008
Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion. European heart journal, 2010, Volume: 31, Issue:13 Topics: Animals; Canrenoic Acid; Eplerenone; Ischemic Preconditioning, Myocardial; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Phosphotransferases; Rabbits; Rats; Rats, Wistar; Spironolactone	2010
Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:7 Topics: Aldosterone; Binding, Competitive; Canrenoic Acid; Canrenone; Drug Interactions; Glucuronosyltransferase; Humans; Hymecromone; In Vitro Techniques; Kidney; Microsomes; Microsomes, Liver; Spironolactone	2010
Liver: diuretic agents for ascites: joining forces from the start? Nature reviews. Gastroenterology & hepatology, 2010, Volume: 7, Issue:6 Topics: Ascites; Canrenoic Acid; Drug Therapy, Combination; Furosemide; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone; Treatment Outcome	2010
Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenone. Therapeutic drug monitoring, 2011, Volume: 33, Issue:1 Topics: Anti-Arrhythmia Agents; Canrenoic Acid; Canrenone; Chemistry, Clinical; Cross Reactions; Digoxin; Immunoassay; Mineralocorticoid Receptor Antagonists; Spironolactone	2011
Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay. Journal of clinical laboratory analysis, 2010, Volume: 24, Issue:6 Topics: Biological Assay; Canrenoic Acid; Canrenone; Cardiotonic Agents; Chemistry, Clinical; Cross Reactions; Digoxin; Drug Interactions; Drug Monitoring; Humans; Immunoassay; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Reagent Kits, Diagnostic; Spironolactone	2010
Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassay. Journal of clinical laboratory analysis, 2012, Volume: 26, Issue:3 Topics: Canrenoic Acid; Canrenone; Digoxin; Humans; Immunoassay; Luminescent Measurements; Models, Molecular; Spironolactone	2012
Importance of the time of initiation of mineralocorticoid receptor antagonists on risk of mortality in patients with heart failure. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2015, Volume: 16, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Canrenoic Acid; Cohort Studies; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prognosis; Spironolactone; Survival Analysis; Treatment Outcome	2015
Tolerance of high and low amounts of PLGA microspheres loaded with mineralocorticoid receptor antagonist in retinal target site. Journal of controlled release : official journal of the Controlled Release Society, 2017, Nov-28, Volume: 266 Topics: Animals; Canrenoic Acid; Ciliary Body; Drug Liberation; Intravitreal Injections; Lactic Acid; Macrophages; Male; Microglia; Microspheres; Mineralocorticoid Receptor Antagonists; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Wistar; Retina; Spironolactone	2017
Topical Administration of Spironolactone-Loaded Nanomicelles Prevents Glucocorticoid-Induced Delayed Corneal Wound Healing in Rabbits. Molecular pharmaceutics, 2018, 03-05, Volume: 15, Issue:3 Topics: Administration, Ophthalmic; Animals; Canrenoic Acid; Cornea; Corneal Injuries; Disease Models, Animal; Glucocorticoids; Humans; Male; Micelles; Mineralocorticoid Receptor Antagonists; Nanoparticles; Polyesters; Polyethylene Glycols; Rabbits; Spironolactone; Tissue Distribution; Treatment Outcome; Wound Healing	2018