Page last updated: 2024-08-16

canrenoic acid and aldosterone

canrenoic acid has been researched along with aldosterone in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (59.02)	18.7374
1990's	9 (14.75)	18.2507
2000's	11 (18.03)	29.6817
2010's	5 (8.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Claire, M; Corvol, P; Menard, J; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C	1
Kudisov, IuM; Razumova, ET; Rossel's, AN; Sidorenko, BA	1
Armanini, D; Fallo, F; Mantero, F; Opocher, G	1
Ferguson, DR; James, PS; Paterson, JY; Saunders, JC; Smith, MW	1
Landais, P; Mavoungou, D; Murakami, T; Nowaczynski, M; Nowaczynski, W; Vitullo, B	1
Corvol, P; Delarue, C; Jegou, S; Kusmierek, MC; Leboulenger, F; Leroux, P; Tonon, MC; Vaillant, R; Vaudry, H	1
Casals-Stenzel, J; Losert, W; Schmalbach, J	1
Brass, B; Mertin, J; Simon, O	1
Kim, KS; Miyamori, I; Morimoto, S; Takeda, R; Uchida, K; Yamamoto, I	1
Aupetit, B; Duchier, J; Legrand, JC	1
Cheng, SC; Harding, BW; Sadee, W; Suzuki, K	1
Bie, P	1
Baethmann, A; Finn, AM; Sadée, W; Schmiedek, P	1
Brown, JA; Garland, HO; Henderson, IW	1
Hofmann, LM; Maibach, HI; Polk, RC	1
Consolo, F; Ferraù, O; Luzza, G; Pitrone, F; Russo, A; Virga, T	1
Käsmayr, J; Theisen, K; Wehling, M	2
Mori, N; Sakai, S; Uozumi, N; Yura, K	1
Nakazawa, S; Node, Y	1
Hoashi, S; Honda, N; Ikebe, H; Irie, F; Kobayashi, N; Mitarai, Y; Taniguchi, K	1
Cuppone, R; Emili, M; Ricci, GL	1
Brem, AS; Morris, DJ; Pacholski, M	1
Ozaki, N; Suzuki, S; Takamura, S; Yoshida, J	1
Kiyose, H; Nagano, M; Tagawa, H; Tanaka, S; Umezu, M; Yamakado, M	1
Boer, P; Dorhout Mees, EJ; Hené, RJ; Koomans, HA	1
Brem, AS; Freiberger, M; Latif, SA; McDermott, MJ; Morris, DJ; Pacholski, M	1
Buse, M; Casals-Stenzel, J; Losert, W	1
Rabinowitz, L; Sarason, RL; Yamauchi, H	2
Freiberger, M; Latif, SA; McDermott, MJ; Morris, DJ	1
Capron, MH; Delarue, C; Kusmierek, MC; Leboulenger, F; Netchitailo, P; Perroteau, I; Roullet, M; Vaudry, H	1
Dubach, UC; Kaissling, B; Le Hir, M	1
Apostolopoulou, K; Lasaridis, AN; Pharmakiotis, A; Spanos, P; Tourkantonis, A	1
Fanti, P; Mantellini, R; Sciarra, F; Tosti-Croce, C	1
Budaj, A; Ceremuzyński, L; Michorowski, B	1
Latif, SA; McDermott, MJ; Morris, DJ	1
Claire, M; Corvol, P; Geering, K; Oblin, ME; Rossier, B	1
Liebich, HG; Mertin, J; Seifert, J	1
Haschke, F; Parth, K; Wimmer, M	1
Albino, G; Angeli, P; Caregaro, L; Ceolotto, G; Dalla Pria, M; De Bei, E; Gatta, A; Merkel, C	1
Boer, P; Koomans, HA; van Buren, M	1
Mori, N; Nario, K; Sakai, S; Yura, K	1
Funder, JW; Young, MJ	1
Blaehr, H; Dahl, HB; Egfjord, M; Kayser, C	1
Brazzarola, P; Degan, M; Delva, P; Lechi, A; Montesi, G; Pastori, C	1
Ogawa, R; Watanabe, T	1
Arvat, E; Broglio, F; Camanni, F; Ghigo, E; Gianotti, L; Giordano, R; Maccagno, B; Maccario, M; Pellegrino, M	1
Remme, WJ	1
Arias, C; Caballero, R; Delpón, E; González, T; Moreno, I; Tamargo, J; Valenzuela, C	1
Bendtzen, K; Hansen, PR; Rieneck, K	1
Bos, R; Findji, L; Lechat, P; Médiani, O; Mougenot, N; Vanhoutte, PM	1
Feuring, M; Horisberger, K; Schmidt, BM; Schultz, A; Wehling, M	1
Albiger, N; Armanini, D; Fiore, C; Mattarello, MJ; Sartorato, P; Scaroni, C	1
Beugels, IP; Cohuet, GM; de Gooyer, ME; Emmen, JM; Hermans, JJ; Hilbers, PA; Minnaard-Huiban, M; Ottenheijm, HC; Pieterse, K; Plate, R; Roumen, L; Ruijters, E; Smits, JF; van Essen, H	1
Blengio, GS; Ciacciarelli, A; Corrocher, R; Falcone, S; Olivieri, O; Pizzolo, F; Signorelli, D	1
Chai, W; Danser, AH; de Jong, FH; de Vries, R; Feelders, RA; Garrelds, IM; Hofland, J; Jansen, PM; van den Bogaerdt, AJ	1
Bowalgaha, K; Knights, KM; Miners, JO	1
Beygui, F; Ecollan, P; Machecourt, J; Montalescot, G; Van Belle, E; Vicaut, E; Zannad, F	1
Adler, GK; Coutinho, P; Maldonado, ER; Pojoga, LH; Rivera, A; Romero, JR; Turchin, A; Williams, GH; Williams, J; Yao, TM; Youte, R	1
Brochu, M; Houde, V; Provencher, M; St-Louis, J	1

Reviews

2 review(s) available for canrenoic acid and aldosterone

Article	Year
Spirolactones: clinical and pharmacologic studies. Advances in nephrology from the Necker Hospital, 1977, Volume: 7 Topics: Aldosterone; Animals; Binding, Competitive; Canrenoic Acid; Canrenone; Diuresis; Humans; Hyperaldosteronism; Hypertension; In Vitro Techniques; Kidney; Mineralocorticoid Receptor Antagonists; Pregnadienes; Protein Binding; Rats; Receptors, Cell Surface; Spironolactone	1977
Mechanism of the antimineralocorticoid effects of spirolactones. Kidney international, 1981, Volume: 20, Issue:1 Topics: Aldosterone; Animals; Anura; Canrenoic Acid; Canrenone; Cattle; Guinea Pigs; Humans; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Steroid; Spironolactone; Veratrum Alkaloids	1981

Trials

9 trial(s) available for canrenoic acid and aldosterone

Article	Year
[Use of the aldosterone antagonist, canrenoate potassium for treating chronic circulatory insufficiency]. Kardiologiia, 1979, Volume: 19, Issue:3 Topics: Adult; Aged; Aldosterone; Canrenoic Acid; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Pregnadienes; Pulmonary Heart Disease; Rheumatic Heart Disease; Water-Electrolyte Balance	1979
Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-over. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Aldosterone; Canrenoic Acid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperaldosteronism; Liver Cirrhosis; Liver Function Tests; Male; Pregnadienes; Random Allocation; Spironolactone	1988
[Clinical study of the efficacy of oral potassium canrenoate and spironolactone in essential arterial hypertension]. Minerva medica, 1983, Apr-07, Volume: 74, Issue:14-15 Topics: Administration, Oral; Adult; Aldosterone; Blood Pressure; Canrenoic Acid; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pregnadienes; Renin; Spironolactone; Time Factors	1983
Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascites. Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Amiloride; Ascites; Canrenoic Acid; Female; Humans; Kidney Tubules, Proximal; Liver Cirrhosis; Male; Middle Aged; Renin-Angiotensin System; Sodium; Uremia	1994
Suppression of surgical hyperaldosteronism by potassium canrenoate during gynecologic surgery under sevoflurane anesthesia. Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Canrenoic Acid; Female; Gynecologic Surgical Procedures; Humans; Hyperaldosteronism; Intraoperative Complications; Male; Methyl Ethers; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Sevoflurane; Sodium	2000
Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:7 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Arginine Vasopressin; Canrenoic Acid; Corticotropin-Releasing Hormone; Dehydroepiandrosterone; Feedback; Female; Humans; Hydrocortisone; Kinetics; Mineralocorticoid Receptor Antagonists; Placebos; Receptors, Mineralocorticoid	2001
Aldosterone blunts human baroreflex sensitivity by a nongenomic mechanism. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2005, Volume: 113, Issue:5 Topics: Adult; Aldosterone; Baroreflex; Blood Pressure; Canrenoic Acid; Cross-Over Studies; Double-Blind Method; Humans; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Placebos	2005
Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate. Journal of endocrinological investigation, 2005, Volume: 28, Issue:3 Topics: Adult; Aldosterone; Blood Pressure; Canrenoic Acid; Electrolytes; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System	2005
Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trial. American heart journal, 2010, Volume: 160, Issue:4 Topics: Aged; Aldosterone; Canrenoic Acid; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Treatment Outcome	2010

Other Studies

50 other study(ies) available for canrenoic acid and aldosterone

Article	Year
[Effect of potassium canrenoate on arterial pressure, plasma renin activity and urinary aldosterone in essential hypertension]. Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:10 Topics: Adolescent; Adult; Aldosterone; Canrenoic Acid; Female; Humans; Hypertension; Male; Middle Aged; Pregnadienes; Renin	1978
Aldosterone induced changes in colonic sodium transport occurring naturally during development in the neonatal pig. The Journal of physiology, 1979, Volume: 292 Topics: Aging; Aldosterone; Animals; Animals, Newborn; Biological Transport; Canrenoic Acid; Colon; Membrane Potentials; Sodium; Swine	1979
Genetic aspects of plasma aldosterone binding globulins in families of patients with essential hypertension, including isolation of novel thermostable homologues from plasma and urine. Journal of steroid biochemistry, 1979, Volume: 11, Issue:1C Topics: Adolescent; Adult; Aged; Aldosterone; Canrenoic Acid; Carrier Proteins; Child; Child, Preschool; Female; Humans; Hypertension; Male; Middle Aged; Pedigree; Serum Globulins	1979
Comparative effects of canrenoate-K and prorenoate-K upon aldosterone biosynthesis in perifused frog interrenal glands. Steroids, 1979, Volume: 34, Issue:3 Topics: Adrenal Glands; Aldosterone; Animals; Anura; Canrenoic Acid; Interrenal Gland; Mineralocorticoid Receptor Antagonists; Pregnadienes; Radioimmunoassay; Ranidae; Spironolactone; Time Factors	1979
Improved method for comparative evaluation of aldosterone antagonists in healthy man. European journal of clinical pharmacology, 1977, Dec-02, Volume: 12, Issue:4 Topics: Adult; Aldosterone; Canrenoic Acid; Drug Evaluation; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Time Factors	1977
[EEG changes following spirolactone treatment (author's transl)]. Medizinische Klinik, 1978, Mar-31, Volume: 73, Issue:13 Topics: Aldosterone; Brain Edema; Canrenoic Acid; Electroencephalography; Encephalitis; Female; Humans; Male; Multiple Sclerosis; Spironolactone	1978
[Measurement of plasma aldosterone by 125I-aldosterone radioimmunoassay kit (author's transl)]. Radioisotopes, 1978, Volume: 27, Issue:6 Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Humans; Radioimmunoassay; Rats; Reagent Kits, Diagnostic; Spironolactone	1978
[Effect of spironolactones on aldosterone synthesis and adrenal metabolism]. Annales d'endocrinologie, 1978, Volume: 39, Issue:5 Topics: Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Ducks; Hydroxylation; Mineralocorticoid Receptor Antagonists; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Sheep; Spironolactone; Steroid Hydroxylases	1978
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinology, 1976, Volume: 99, Issue:4 Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Cattle; Cytochrome P-450 Enzyme System; Humans; Hyperplasia; Mitochondria; Oxidation-Reduction; Pregnadienes; Spectrum Analysis; Spironolactone; Steroid Hydroxylases	1976
Sodium excretion and sodium-free volume expansion in dogs: effect of inhibition of aldosterone activity by canrenoate. Acta physiologica Scandinavica, 1976, Volume: 98, Issue:2 Topics: Aldosterone; Animals; Canrenoic Acid; Diuresis; Dogs; Female; Natriuresis; Pregnadienes; Renin; Sodium	1976
Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite. Steroids, 1975, Volume: 25, Issue:3 Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Dogs; Humans; Mass Spectrometry; Pregnadienes; Rabbits; Radioimmunoassay; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spironolactone; Time Factors	1975
Micropuncture study of the renal responses of the urodele amphibian Necturus maculosus to injections of arginine vasotocin and an anti-aldosterone compound. The Journal of experimental biology, 1975, Volume: 63, Issue:1 Topics: Aldosterone; Amphibians; Animals; Calcium; Canrenoic Acid; Female; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Potassium; Regional Blood Flow; Sodium; Vasotocin; Vitamin B 12; Water	1975
Renal clearance of canrenoate in normal man. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:6 Topics: 17-Ketosteroids; Aldosterone; Canrenoic Acid; Canrenone; Humans; Hydroxysteroids; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Pregnadienes; Renin	1975
[Interference of canrenoate potassium with plasma renin activity. Note I. Effects of canrenoate potassiumon plasma renin activity in patients with essential hypertension]. Bollettino della Societa italiana di biologia sperimentale, 1975, Dec-30, Volume: 51, Issue:24 Topics: Adult; Aged; Aldosterone; Canrenoic Acid; Electrolytes; Female; Humans; Hypertension; Male; Middle Aged; Pregnadienes; Renin	1975
Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway? The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 1 Topics: Aldosterone; Calcium; Canrenoic Acid; Canrenone; Carrier Proteins; Dexamethasone; DNA; Humans; Hydrocortisone; In Vitro Techniques; Kinetics; Leukocytes, Mononuclear; Models, Biological; Potassium; Propionates; Reference Values; Sodium; Sodium-Hydrogen Exchangers	1991
Effect of aldosterone antagonist on the DC potential in the endolymphatic sac. The Annals of otology, rhinology, and laryngology, 1991, Volume: 100, Issue:1 Topics: Aldosterone; Animals; Canrenoic Acid; Endolymphatic Sac; Guinea Pigs; Membrane Potentials	1991
Aldosterone influences free intracellular calcium in human mononuclear leukocytes in vitro. Cell calcium, 1990, Volume: 11, Issue:9 Topics: Adolescent; Adult; Aged; Aldosterone; Amiloride; Calcium; Canrenoic Acid; Canrenone; Corticosterone; Cycloheximide; Dactinomycin; Humans; Hydrocortisone; Leukocytes, Mononuclear; Middle Aged	1990
Clinical study of potassium canrenoate on raised intracranial pressure. Advances in neurology, 1990, Volume: 52 Topics: Aldosterone; Brain Neoplasms; Canrenoic Acid; Humans; Intracranial Aneurysm; Intracranial Pressure; Pregnadienes	1990
[Changes in aldosterone and PRA due to the administration of potassium canrenoate in laparotomized patients with liver cirrhosis]. Masui. The Japanese journal of anesthesiology, 1988, Volume: 37, Issue:5 Topics: Aldosterone; Anesthesia, Epidural; Canrenoic Acid; Humans; Liver Cirrhosis; Potassium; Pregnadienes; Renin; Sodium	1988
Time-dependent aldosterone metabolism in toad urinary bladder. The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 2 Topics: Aldosterone; Animals; Bufo marinus; Canrenoic Acid; Chromatography, High Pressure Liquid; In Vitro Techniques; Kinetics; Sodium; Tritium; Urinary Bladder	1988
Effect of aldosterone antagonists on aldosterone-induced activation of Mg2+ -HCO3- -ATPase and carbonic anhydrase in rat intestinal mucosa. Journal of steroid biochemistry, 1985, Volume: 23, Issue:1 Topics: Adenosine Triphosphatases; Adrenalectomy; Aldosterone; Animals; Ca(2+) Mg(2+)-ATPase; Canrenoic Acid; Carbonic Anhydrases; Dactinomycin; Duodenum; Enzyme Activation; Intestinal Mucosa; Jejunum; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone	1985
Extrarenal role of aldosterone in the regulation of blood pressure. American journal of hypertension, 1988, Volume: 1, Issue:3 Pt 1 Topics: Adult; Aged; Aldosterone; Blood Pressure; Canrenoic Acid; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension, Renovascular; Kidney; Middle Aged; Vascular Resistance; Vasoconstriction	1988
Adaptation to chronic potassium loading in normal man. Mineral and electrolyte metabolism, 1986, Volume: 12, Issue:3 Topics: Acetazolamide; Adaptation, Biological; Administration, Oral; Adult; Aldosterone; Body Weight; Canrenoic Acid; Humans; Infusions, Parenteral; Injections, Intravenous; Kidney Tubules; Male; Potassium; Renin; Spironolactone; Time Factors	1986
The effects of antimineralocorticoids on synthesis of aldosterone metabolites in target tissues. Journal of steroid biochemistry, 1986, Volume: 24, Issue:1 Topics: Aldosterone; Animals; Bufonidae; Canrenoic Acid; Corticosterone; In Vitro Techniques; Kidney; Male; Mineralocorticoid Receptor Antagonists; Progesterone; Rats; Tritium; Urinary Bladder	1986
Progestogens with antimineralocorticoid activity. Arzneimittel-Forschung, 1985, Volume: 35, Issue:2 Topics: Adrenalectomy; Aldosterone; Androstadienes; Androstenes; Animals; Canrenoic Acid; Canrenone; Cyproterone; Dose-Response Relationship, Drug; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Norethindrone; Norgestrel; Norpregnenes; Potassium; Progesterone; Progesterone Congeners; Rats; Rats, Inbred Strains; Sodium; Spironolactone	1985
Effect of aldosterone on potassium excretion during potassium chloride infusion in sheep. The American journal of physiology, 1985, Volume: 249, Issue:4 Pt 2 Topics: Aldosterone; Animals; Canrenoic Acid; Female; Homeostasis; Kidney; Mineralocorticoid Receptor Antagonists; Potassium; Potassium Chloride; Sheep; Sodium	1985
The synthesis of reduced metabolites of aldosterone by subcellular fractions of rat kidney: effects of antimineralocorticoids. Journal of steroid biochemistry, 1985, Volume: 23, Issue:4 Topics: Aldosterone; Animals; Canrenoic Acid; Chromatography, High Pressure Liquid; Corticosterone; In Vitro Techniques; Kidney; Male; Mineralocorticoids; Progesterone; Rats; Rats, Inbred Strains	1985
In vitro study of frog (Rana ridibunda Pallas) interrenal function by use of a simplified perifusion system-VI. Inhibition of aldosterone biosynthesis by SC 14266. Journal of steroid biochemistry, 1981, Volume: 15 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Canrenoic Acid; In Vitro Techniques; Male; Perfusion; Pregnadienes; Rana ridibunda; Receptors, Steroid	1981
Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. II. Changes in Na-K-ATPase activity. Cell and tissue research, 1982, Volume: 224, Issue:3 Topics: Adaptation, Physiological; Aldosterone; Animals; Canrenoic Acid; Desoxycorticosterone; Diet; Diet, Sodium-Restricted; Female; Kidney Tubules; Kidney Tubules, Collecting; Kidney Tubules, Distal; Potassium; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase	1982
The effects of canrenoate K on corticosteroid biosynthesis in nephrectomized dogs. Journal of steroid biochemistry, 1984, Volume: 20, Issue:4A Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Canrenoic Acid; Dogs; Hydrocortisone; In Vitro Techniques; Kinetics; Nephrectomy; Pregnadienes; Renin	1984
Sheep renal potassium excretion: efferent kaliuretic regulatory factors. The American journal of physiology, 1984, Volume: 247, Issue:3 Pt 2 Topics: Aldosterone; Animals; Canrenoic Acid; Female; Infusions, Parenteral; Mineralocorticoid Receptor Antagonists; Potassium; Potassium Chloride; Potassium Deficiency; Sheep; Sodium	1984
Single-dose i.v. Aldactone for congestive heart failure: a preliminary observation. International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:8 Topics: Aged; Aldosterone; Canrenoic Acid; Diuresis; Female; Heart Failure; Humans; Injections, Intravenous; Male; Middle Aged; Pregnadienes; Time Factors	1983
The effects of adrenal and gonadal steroids and K+-canrenoate on the metabolism of aldosterone by rat liver microsomes. Steroids, 1983, Volume: 42, Issue:3 Topics: Aldosterone; Animals; Canrenoic Acid; Chromatography, High Pressure Liquid; Corticosterone; Cytochrome P-450 Enzyme System; Estradiol; Gonadal Steroid Hormones; Male; Microsomes, Liver; Pregnadienes; Progesterone; Rats; Rats, Inbred Strains; Testosterone	1983
[Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical studies]. Fortschritte der Medizin, 1982, Nov-04, Volume: 100, Issue:41 Topics: Adult; Aldosterone; Animals; Canrenoic Acid; Female; Humans; Lymphocytes; Microscopy, Electron; Pregnadienes; Rats; Rats, Inbred Strains; Spironolactone	1982
Hyperaldosteronism after heart surgery in children. Part I: Treatment with aldosterone antagonists. Padiatrie und Padologie, 1981, Volume: 16, Issue:3 Topics: Adolescent; Aldosterone; Canrenoic Acid; Child; Child, Preschool; Heart Defects, Congenital; Hematocrit; Humans; Hyperaldosteronism; Infant; Mineralocorticoid Receptor Antagonists; Postoperative Complications; Potassium; Sodium; Spironolactone	1981
Effects of acute mineralocorticoid and glucocorticoid receptor blockade on the excretion of an acute potassium load in healthy humans. The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:4 Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Canrenoic Acid; Diuresis; Glucocorticoids; Humans; Injections, Intravenous; Kidney; Male; Metabolic Clearance Rate; Mifepristone; Mineralocorticoids; Potassium; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sodium	1993
Effect of intravenously applied canrenoate on ampullar endolymphatic potential. Acta oto-laryngologica, 1995, Volume: 115, Issue:5 Topics: Aldosterone; Animals; Canrenoic Acid; Dose-Response Relationship, Drug; Electrophysiology; Endolymph; Guinea Pigs; Infusions, Intravenous; Mineralocorticoid Receptor Antagonists; Semicircular Canals	1995
The renin-angiotensin-aldosterone system in experimental mineralocorticoid-salt-induced cardiac fibrosis. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 1 Topics: Aldosterone; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Canrenoic Acid; Cardiomegaly; Collagen; Corticosterone; Epithelium; Fibrosis; Heart; Imidazoles; Indoles; Losartan; Male; Myocardium; Nephrectomy; Organ Size; Perindopril; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Tetrazoles	1996
Aldosterone metabolism in cultures of rat renal cortical and medullary cells. Scandinavian journal of clinical and laboratory investigation, 1999, Volume: 59, Issue:2 Topics: Aldosterone; Animals; Canrenoic Acid; Carbon Radioisotopes; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Kidney Cortex; Kidney Medulla; Liver; Mifepristone; Rats; Rats, Wistar; Receptors, Glucocorticoid	1999
Intralymphocyte free magnesium in patients with primary aldosteronism: aldosterone and lymphocyte magnesium homeostasis. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:1 Pt 1 Topics: Adult; Aldosterone; Antiporters; Calcium; Canrenoic Acid; Case-Control Studies; Female; Homeostasis; Humans; Hyperaldosteronism; In Vitro Techniques; Lymphocytes; Magnesium; Magnesium Deficiency; Male; Middle Aged; Mineralocorticoid Receptor Antagonists	2000
Aldosterone and myocardial infarction--are aldosterone antagonists needed to prevent remodelling or does ACE inhibition suffice? Cardiovascular drugs and therapy, 2001, Volume: 15, Issue:4 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Canrenoic Acid; Captopril; Cardiomegaly; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Peptidyl-Dipeptidase A	2001
Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels. Circulation, 2003, Feb-18, Volume: 107, Issue:6 Topics: Aldosterone; Animals; Canrenoic Acid; Cation Transport Proteins; CHO Cells; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electric Stimulation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Spironolactone; Trans-Activators; Transcriptional Regulator ERG; Transfection	2003
Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunology letters, 2004, Feb-15, Volume: 91, Issue:2-3 Topics: Aldosterone; Canrenoic Acid; Cells, Cultured; Cyproterone Acetate; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Leukocytes, Mononuclear; Lipopolysaccharides; Phytohemagglutinins; Pregnadienes; RNA, Messenger; Spironolactone; Transcription, Genetic	2004
Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist. Journal of cardiovascular pharmacology, 2005, Volume: 45, Issue:1 Topics: Adrenergic beta-Agonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Canrenoic Acid; Fibrosis; Heart Failure; Isoproterenol; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta	2005
Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology, 2008, Volume: 149, Issue:1 Topics: Aldosterone; Animals; Canrenoic Acid; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Drug Evaluation, Preclinical; Fadrozole; Fibrosis; Gene Expression Regulation; Heart; Heart Failure; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship; Treatment Outcome	2008
Menopause not aldosterone-to-renin ratio predicts blood pressure response to a mineralocorticoid receptor antagonist in primary care hypertensive patients. American journal of hypertension, 2008, Volume: 21, Issue:9 Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aldosterone; Blood Pressure; Canrenoic Acid; Female; Humans; Hypertension; Male; Menopause; Middle Aged; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin; Verapamil	2008
Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors? Journal of hypertension, 2010, Volume: 28, Issue:5 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aldosterone; Animals; Base Sequence; Canrenoic Acid; Child; Child, Preschool; Corticosterone; DNA Primers; Female; Gene Expression; Heart; Hemodynamics; Hormone Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; Mifepristone; Myocardium; Rats; Rats, Wistar; Receptors, Mineralocorticoid; RNA, Messenger; Steroids; Young Adult	2010
Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:7 Topics: Aldosterone; Binding, Competitive; Canrenoic Acid; Canrenone; Drug Interactions; Glucuronosyltransferase; Humans; Hymecromone; In Vitro Techniques; Kidney; Microsomes; Microsomes, Liver; Spironolactone	2010
Activation of the mineralocorticoid receptor increases striatin levels. American journal of hypertension, 2012, Volume: 25, Issue:2 Topics: Aldosterone; Angiotensin II; Animals; Aorta; Calmodulin-Binding Proteins; Canrenoic Acid; Cells, Cultured; Diet, Sodium-Restricted; Endothelial Cells; Enzyme Inhibitors; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Myocardium; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Receptors, Mineralocorticoid	2012
Mineralocorticoids participate in the reduced vascular reactivity of pregnant rats. American journal of physiology. Heart and circulatory physiology, 2012, Mar-01, Volume: 302, Issue:5 Topics: Aldosterone; Animals; Aorta, Thoracic; Benzimidazoles; Calcium Channel Blockers; Canrenoic Acid; Cromakalim; Female; KATP Channels; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Potassium Channels, Calcium-Activated; Potassium Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Vasoconstrictor Agents; Vasodilator Agents	2012