cannabidiol and piperine

Nowadays, therapeutic indications for cannabinoids, specifically Δ

Topics: Administration, Buccal; Administration, Oral; Adult; Alkaloids; Benzodioxoles; Biological Availability; Cannabidiol; Cross-Over Studies; Dronabinol; Drug Delivery Systems; Fasting; Healthy Volunteers; Humans; Male; Nanospheres; Piperidines; Polyunsaturated Alkamides; Young Adult

Piperine is an alkaloid naturally found in black pepper with a myriad of pharmacological attributes. Piperine's most far reaching indication is drug absorption enhancment, with supportive data regarding its ability to inhibit first pass effect mechanisms. However, alongside these findings, the role of piperine as an absorption enhancer is undermined with publications stating an apparent effect of a metabolic inducer. The aim of this work is to investigate the effect of repeated administration of piperine in a lipid-based formulation ,on oral absorption of cannabidiol (CBD), compared to acute piperine dosing. The effect of piperine on CBD absorption was determined pre-clinically in the freely moving rat model. Results of this work demonstrated that there was no significant difference in piperine's effect, when given chronically or in a single dose regimen. Both groups resulted in approximate 2.5-fold increase in oral bioavailability of CBD compared to control group without piperine.

Topics: Administration, Oral; Alkaloids; Animals; Benzodioxoles; Biological Availability; Cannabidiol; Male; Oral Mucosal Absorption; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar

The lipophilic phytocannabinoids cannabidiol (CBD) and Δ

Topics: Administration, Oral; Alkaloids; Animals; Benzodioxoles; Biological Availability; Cannabidiol; Curcumin; Dronabinol; Drug Delivery Systems; Emulsions; Excipients; Gastrointestinal Absorption; Lipids; Male; Nanoparticles; Piperidines; Polyunsaturated Alkamides; Rats, Wistar; Resveratrol; Stilbenes