candoxatrilat has been researched along with thiorphan in 5 studies
| Studies (candoxatrilat) | Trials (candoxatrilat) | Recent Studies (post-2010) (candoxatrilat) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 46 | 10 | 1 | 665 | 50 | 82 |
| 46 | 10 | 1 | 8 | 0 | 3 |
| Protein | Taxonomy | candoxatrilat (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.02 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.5 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barclay, PL; Danilewicz, JC; Samuels, GM | 1 |
| Berry, C; De Lombaert, S; Ghai, RD; Ksander, GM; Sakane, Y; Trapani, AJ | 1 |
| Wilkins, MR | 1 |
| Ferro, CJ; Haynes, WG; Spratt, JC; Webb, DJ | 1 |
| Abbenante, G; Fairlie, DP; Leung, D | 1 |
2 review(s) available for candoxatrilat and thiorphan
| Article | Year |
|---|---|
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan | 1993 |
Protease inhibitors: current status and future prospects.
Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Metalloendopeptidases; Models, Molecular; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors | 2000 |
1 trial(s) available for candoxatrilat and thiorphan
| Article | Year |
|---|---|
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction | 1998 |
2 other study(ies) available for candoxatrilat and thiorphan
| Article | Year |
|---|---|
Inhibitory potencies of UK-69 578 and thiorphan.
Topics: Atrial Natriuretic Factor; Carbamates; Cyclohexanecarboxylic Acids; Depression, Chemical; Propionates; Substrate Specificity; Thiorphan | 1990 |
A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors.
Topics: Animals; Atrial Natriuretic Factor; beta-Alanine; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Kidney Cortex; Male; Methods; Neprilysin; Organophosphonates; Rats; Rats, Sprague-Dawley; Thiorphan | 1995 |