Page last updated: 2024-09-03

candoxatrilat and enalapril

candoxatrilat has been researched along with enalapril in 3 studies

Compound Research Comparison

Studies (candoxatrilat)	Trials (candoxatrilat)	Recent Studies (post-2010) (candoxatrilat)	Studies (enalapril)	Trials (enalapril)	Recent Studies (post-2010) (enalapril)
46	10	1	6,311	1,924	859

Protein Interaction Comparison

Protein	Taxonomy	enalapril (IC50)
Angiotensin-converting enzyme	Homo sapiens (human)	0.3536
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	2.7083
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	1.2
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	0.14
Angiotensin-converting enzyme 2	Homo sapiens (human)	0.14

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (66.67)	18.2507
2000's	1 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abbenante, G; Fairlie, DP; Leung, D	1
Cramb, G; Lang, CC; Motwani, JG; Struthers, AD	1
Ferro, CJ; Haynes, WG; Spratt, JC; Webb, DJ	1

Reviews

1 review(s) available for candoxatrilat and enalapril

Article	Year
Protease inhibitors: current status and future prospects. Journal of medicinal chemistry, 2000, Feb-10, Volume: 43, Issue:3 Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Metalloendopeptidases; Models, Molecular; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors	2000

Trials

2 trial(s) available for candoxatrilat and enalapril

Article	Year
Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 1 Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Interactions; Enalapril; Glomerular Filtration Rate; Humans; Male; Natriuresis; Neprilysin; Renal Circulation; Single-Blind Method	1995
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo. Circulation, 1998, Jun-16, Volume: 97, Issue:23 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction	1998

Article

Year

Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.

Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 1

Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Interactions; Enalapril; Glomerular Filtration Rate; Humans; Male; Natriuresis; Neprilysin; Renal Circulation; Single-Blind Method

1995

Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo.

Circulation, 1998, Jun-16, Volume: 97, Issue:23

Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction

1998