candoxatrilat has been researched along with cyclic gmp in 12 studies
| Studies (candoxatrilat) | Trials (candoxatrilat) | Recent Studies (post-2010) (candoxatrilat) | Studies (cyclic gmp) | Trials (cyclic gmp) | Recent Studies (post-2010) (cyclic gmp) |
|---|---|---|---|---|---|
| 46 | 10 | 1 | 22,346 | 333 | 4,062 |
| Protein | Taxonomy | candoxatrilat (IC50) | cyclic gmp (IC50) |
|---|---|---|---|
| Phosphodiesterase | Bos taurus (cattle) | 0.1 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | 2.4 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | 2.4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirk, JE; Moore, KP; Settle, SL; Taylor, SA; Unwin, RJ; Wilkins, MR | 1 |
| Cramb, G; Lang, CC; Motwani, JG; Struthers, AD | 1 |
| Cleland, JG; Good, JM; Jackson, N; Oakley, CM; Peters, M; Wilkins, M | 1 |
| Iimura, O; Shimamoto, K; Ura, N | 1 |
| Kirk, JE; Wilkins, MR | 1 |
| Barclay, PL; Scott, JM; Shepperson, NB | 1 |
| Aoyama, T; Iimura, O; Iwata, M; Nomura, N; Shimamoto, K; Takagawa, Y; Ura, N | 1 |
| Amanaka, K; Kugiyama, K; Matsumura, T; Ohgushi, M; Sugiyama, S; Suzuki, M; Yasue, H | 1 |
| Cattell, WR; Dawnay, AB; Harwood, SM; Lipkin, GW; Raine, AE | 1 |
| Dawnay, AB; Harwood, SM; Lipkin, GW; Raine, AE; Thuraisingham, R | 1 |
| Barclay, PT; Burnett, JC; Chen, HH; Jougasaki, M; Lisy, O; Schirger, JA | 1 |
| Aragno, M; Danni, O; Mastrocola, R; Mengozzi, G; Parola, M; Restivo, F; Rizzetto, M; Rosina, F; Sansoè, G; Smedile, A | 1 |
4 trial(s) available for candoxatrilat and cyclic gmp
| Article | Year |
|---|---|
Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Interactions; Enalapril; Glomerular Filtration Rate; Humans; Male; Natriuresis; Neprilysin; Renal Circulation; Single-Blind Method | 1995 |
Renal response to candoxatrilat in patients with heart failure.
Topics: Aged; Aldosterone; Atrial Natriuretic Factor; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Double-Blind Method; Drug Administration Schedule; Electrolytes; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Neprilysin; Renal Circulation; Sodium; Urine; Vasoactive Intestinal Peptide | 1995 |
Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.
Topics: Adult; Aged; Albuminuria; Atrial Natriuretic Factor; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Double-Blind Method; Hemodynamics; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuresis; Neprilysin; Protease Inhibitors; Renal Circulation | 1997 |
Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients.
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Cyclosporine; Diuresis; Double-Blind Method; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Neprilysin; Protease Inhibitors; Regional Blood Flow; Renal Circulation; Sodium; Vascular Resistance | 1997 |
8 other study(ies) available for candoxatrilat and cyclic gmp
| Article | Year |
|---|---|
Response to atrial natriuretic peptide, endopeptidase 24.11 inhibitor and C-ANP receptor ligand in the rat.
Topics: Animals; Arteriovenous Shunt, Surgical; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuretics; Glomerular Filtration Rate; Lithium; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Wistar | 1992 |
The natriuretic mechanisms of neutral endopeptidase inhibitor in rats.
Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Kallikrein-Kinin System; Kidney; Kinins; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Sodium | 1994 |
Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuretics; Glomerular Filtration Rate; Infusions, Intravenous; Kidney; Ligands; Male; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Peptide Fragments; Rats; Rats, Wistar; Receptors, Atrial Natriuretic Factor; Sodium | 1993 |
Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Cyclohexanecarboxylic Acids; Hemodynamics; Male; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Renin | 1993 |
The mechanisms of the renal effects of neutral endopeptidase inhibitor in rats.
Topics: Adrenergic beta-Antagonists; Animals; Arginine; Atrial Natriuretic Factor; Bradykinin; Cyclic GMP; Cyclohexanecarboxylic Acids; Kidney; Kinins; Male; Neprilysin; Nitric Oxide; omega-N-Methylarginine; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1995 |
Neutral endopeptidase 24.11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils-induced endothelial cytotoxity.
Topics: Animals; Atrial Natriuretic Factor; Calcium; Cells, Cultured; Cyclic GMP; Cyclohexanecarboxylic Acids; Dogs; Endothelium, Vascular; Female; Humans; Male; Myocardial Infarction; N-Formylmethionine Leucyl-Phenylalanine; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Neutrophils | 1996 |
Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin.
Topics: Adrenomedullin; Animals; Blood Flow Velocity; Cyclic AMP; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Dogs; Glomerular Filtration Rate; Kidney; Male; Natriuresis; Neprilysin; Peptides; Protease Inhibitors; Vascular Resistance; Vasodilator Agents | 1998 |
Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Carbon Tetrachloride; Cyclic GMP; Cyclohexanecarboxylic Acids; Cytokines; Endothelin-1; Humans; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Male; Neprilysin; Portal Vein; Protease Inhibitors; Rats; Rats, Wistar; Vascular Resistance | 2005 |