candoxatrilat has been researched along with atrial natriuretic factor in 31 studies
| Studies (candoxatrilat) | Trials (candoxatrilat) | Recent Studies (post-2010) (candoxatrilat) | Studies (atrial natriuretic factor) | Trials (atrial natriuretic factor) | Recent Studies (post-2010) (atrial natriuretic factor) |
|---|---|---|---|---|---|
| 46 | 10 | 1 | 15,455 | 1,105 | 1,760 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 27 (87.10) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirk, JE; Moore, KP; Settle, SL; Taylor, SA; Unwin, RJ; Wilkins, MR | 1 |
| Busse, R; Drexler, H; Holtz, J; Just, H; Kurz, S; Münzel, T; Steinhauer, H | 1 |
| Barclay, PL; Bennett, JA; Greengrass, PM; Griffin, A; Samuels, GM; Shepperson, NB | 1 |
| Hughes, JM; Winter, RJ; Zhao, L | 2 |
| Dargie, HJ; Dilly, SG; Henderson, E; Jardine, A; Northridge, DB | 1 |
| Hughes, JM; Krausz, T; Winter, RJ; Zhao, L | 1 |
| Barclay, PL; Bennett, JA; Samuels, GM; Shepperson, NB | 2 |
| Barclay, PL; Danilewicz, JC; Samuels, GM | 1 |
| Connell, JM; Cussans, NJ; Davidson, G; Dilly, SG; Doyle, J; Jardine, AG; Leckie, BL; Lever, AF; Northridge, D | 1 |
| Archibald, M; Dargie, HJ; Dilly, SG; Findlay, IN; Jardine, AG; Northridge, DB | 1 |
| Barclay, PL; Barnish, IT; Brown, D; Campbell, SF; Danilewicz, JC; James, K; Samuels, GM; Terrett, NK; Wythes, MJ | 1 |
| Alabaster, CT; Barclay, PL; Connell, JM; Dargie, HJ; Dilly, SG; Findlay, IN; Jardine, AG; Lever, AF; Northridge, DB; Samuels, GM | 1 |
| Cramb, G; Lang, CC; Motwani, JG; Struthers, AD | 1 |
| Cleland, JG; Good, JM; Jackson, N; Oakley, CM; Peters, M; Wilkins, M | 1 |
| Iimura, O; Shimamoto, K; Ura, N | 1 |
| Berry, C; De Lombaert, S; Ghai, RD; Ksander, GM; Sakane, Y; Trapani, AJ | 1 |
| Aoyama, T; Iimura, O; Iwata, M; Kuroda, S; Nomura, N; Shimamoto, K; Ura, N | 1 |
| Kirk, JE; Wilkins, MR | 1 |
| Barclay, PL; Scott, JM; Shepperson, NB | 1 |
| Lipkin, GW; Macdougall, IC; Raine, AE | 1 |
| Aoyama, T; Iimura, O; Iwata, M; Nomura, N; Shimamoto, K; Takagawa, Y; Ura, N | 2 |
| Amanaka, K; Kugiyama, K; Matsumura, T; Ohgushi, M; Sugiyama, S; Suzuki, M; Yasue, H | 1 |
| Cattell, WR; Dawnay, AB; Harwood, SM; Lipkin, GW; Raine, AE | 1 |
| Dawnay, AB; Harwood, SM; Lipkin, GW; Raine, AE; Thuraisingham, R | 1 |
| Ferro, CJ; Haynes, WG; Spratt, JC; Webb, DJ | 1 |
| Becker, M; Pankow, K; Schultheiss, HP; Siems, WE; Stepan, H; Walther, T | 1 |
| Aragno, M; Danni, O; Mastrocola, R; Mengozzi, G; Parola, M; Restivo, F; Rizzetto, M; Rosina, F; Sansoè, G; Smedile, A | 1 |
10 trial(s) available for candoxatrilat and atrial natriuretic factor
| Article | Year |
|---|---|
Increased circulating atrial natriuretic factor concentrations in patients with chronic heart failure after inhibition of neutral endopeptidase: effects on diastolic function.
Topics: Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Cyclohexanecarboxylic Acids; Heart Rate; Humans; Male; Middle Aged; Neprilysin; Pulmonary Wedge Pressure; Random Allocation; Single-Blind Method; Ventricular Function, Left | 1992 |
The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
Topics: Adult; Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Carbamates; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Injections, Intravenous; Kidney; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Renin; Sodium | 1990 |
Inhibition of the metabolism of atrial natriuretic factor causes diuresis and natriuresis in chronic heart failure.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Carbamates; Cardiac Output, Low; Chronic Disease; Cyclohexanecarboxylic Acids; Diuresis; Dose-Response Relationship, Drug; Hemodynamics; Humans; Kidney; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Pulmonary Wedge Pressure; Renin; Sodium | 1990 |
Effects of UK 69 578: a novel atriopeptidase inhibitor.
Topics: Animals; Atrial Natriuretic Factor; Clinical Trials as Topic; Coronary Disease; Cyclohexanecarboxylic Acids; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Drug Evaluation, Preclinical; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Natriuresis; Nephrectomy; Neprilysin; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Interactions; Enalapril; Glomerular Filtration Rate; Humans; Male; Natriuresis; Neprilysin; Renal Circulation; Single-Blind Method | 1995 |
Renal response to candoxatrilat in patients with heart failure.
Topics: Aged; Aldosterone; Atrial Natriuretic Factor; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Double-Blind Method; Drug Administration Schedule; Electrolytes; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Neprilysin; Renal Circulation; Sodium; Urine; Vasoactive Intestinal Peptide | 1995 |
Prolonged elevation of plasma atrial natriuretic factor does not increase erythropoietin levels in patients with chronic renal failure.
Topics: Atrial Natriuretic Factor; Cyclohexanecarboxylic Acids; Double-Blind Method; Erythropoietin; Humans; Kidney Failure, Chronic; Male; Neprilysin | 1993 |
Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.
Topics: Adult; Aged; Albuminuria; Atrial Natriuretic Factor; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Double-Blind Method; Hemodynamics; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuresis; Neprilysin; Protease Inhibitors; Renal Circulation | 1997 |
Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients.
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Cross-Over Studies; Cyclic GMP; Cyclohexanecarboxylic Acids; Cyclosporine; Diuresis; Double-Blind Method; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Neprilysin; Protease Inhibitors; Regional Blood Flow; Renal Circulation; Sodium; Vascular Resistance | 1997 |
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction | 1998 |
21 other study(ies) available for candoxatrilat and atrial natriuretic factor
| Article | Year |
|---|---|
Response to atrial natriuretic peptide, endopeptidase 24.11 inhibitor and C-ANP receptor ligand in the rat.
Topics: Animals; Arteriovenous Shunt, Surgical; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuretics; Glomerular Filtration Rate; Lithium; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Wistar | 1992 |
Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure.
Topics: Aged; Atrial Natriuretic Factor; Cardiac Output; Chronic Disease; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Female; Heart Failure; Hemodynamics; Hormones; Humans; Kidney; Male; Middle Aged; Neprilysin; Time Factors | 1992 |
The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade.
Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Half-Life; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Molecular Sequence Data; Nephrectomy; Neprilysin; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 1992 |
Effects of natriuretic peptides and neutral endopeptidase 24.11 inhibition in isolated perfused rat lung.
Topics: Animals; Atrial Natriuretic Factor; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Drug Interactions; Hypoxia; Male; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Pulmonary Artery; Pulmonary Circulation; Pulmonary Wedge Pressure; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 1992 |
Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cyclohexanecarboxylic Acids; Hypertension, Pulmonary; Hypoxia; Male; Neprilysin; Pulmonary Artery; Rats; Rats, Inbred Strains | 1991 |
The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action.
Topics: Animals; Atrial Natriuretic Factor; Carbamates; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Half-Life; Kidney; Kidney Glomerulus; Male; Nephrectomy; Peptide Fragments; Propionates; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1991 |
Inhibition of neutral endopeptidase (EC 3.4.24.11) leads to an atrial natriuretic factor-mediated natriuretic, diuretic and antihypertensive response in rodents.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclohexanecarboxylic Acids; Desoxycorticosterone; Diuresis; Hypertension; Immune Sera; Natriuresis; Neprilysin; Rats; Rats, Inbred Strains | 1991 |
Inhibitory potencies of UK-69 578 and thiorphan.
Topics: Atrial Natriuretic Factor; Carbamates; Cyclohexanecarboxylic Acids; Depression, Chemical; Propionates; Substrate Specificity; Thiorphan | 1990 |
UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic.
Topics: Animals; Atrial Natriuretic Factor; Chemical Phenomena; Chemistry; Cyclohexanecarboxylic Acids; Diuretics; Humans; Male; Mice; Microvilli; Natriuresis; Neprilysin; Rats | 1989 |
The natriuretic mechanisms of neutral endopeptidase inhibitor in rats.
Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuresis; Kallikrein-Kinin System; Kidney; Kinins; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Sodium | 1994 |
A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors.
Topics: Animals; Atrial Natriuretic Factor; beta-Alanine; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Kidney Cortex; Male; Methods; Neprilysin; Organophosphonates; Rats; Rats, Sprague-Dawley; Thiorphan | 1995 |
The role of kinins and atrial natriuretic peptide on the renal effects of neutral endopeptidase inhibitor in rats.
Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Cyclohexanecarboxylic Acids; Diuresis; Kidney; Kinins; Male; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley | 1994 |
Reversal of pulmonary vascular remodelling following hypoxic exposure: no effect of infusion of atrial natriuretic factor and neutral endopeptidase inhibitor.
Topics: Animals; Atrial Natriuretic Factor; Cyclohexanecarboxylic Acids; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Muscle, Smooth, Vascular; Neprilysin; Rats; Rats, Wistar; Time Factors | 1994 |
Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclohexanecarboxylic Acids; Diuretics; Glomerular Filtration Rate; Infusions, Intravenous; Kidney; Ligands; Male; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Peptide Fragments; Rats; Rats, Wistar; Receptors, Atrial Natriuretic Factor; Sodium | 1993 |
Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Cyclohexanecarboxylic Acids; Hemodynamics; Male; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Renin | 1993 |
The mechanisms of the renal effects of neutral endopeptidase inhibitor in rats.
Topics: Adrenergic beta-Antagonists; Animals; Arginine; Atrial Natriuretic Factor; Bradykinin; Cyclic GMP; Cyclohexanecarboxylic Acids; Kidney; Kinins; Male; Neprilysin; Nitric Oxide; omega-N-Methylarginine; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1995 |
The role of kinins and atrial natriuretic peptide on the renal effects of neutral endopeptidase inhibitor in normotensive and hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Atrial Natriuretic Factor; Bradykinin; Cyclohexanecarboxylic Acids; Desoxycorticosterone; Hypertension; Kidney; Kinins; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1995 |
Neutral endopeptidase 24.11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils-induced endothelial cytotoxity.
Topics: Animals; Atrial Natriuretic Factor; Calcium; Cells, Cultured; Cyclic GMP; Cyclohexanecarboxylic Acids; Dogs; Endothelium, Vascular; Female; Humans; Male; Myocardial Infarction; N-Formylmethionine Leucyl-Phenylalanine; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Neutrophils | 1996 |
Candoxatrilat. UK 73967.
Topics: Animals; Atrial Natriuretic Factor; Cyclohexanecarboxylic Acids; Dogs; Drugs, Investigational; Endopeptidases; Heart Failure; Hemodynamics; Humans; Neurotransmitter Agents; Protease Inhibitors; Renal Agents | 1999 |
Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide.
Topics: Animals; Atrial Natriuretic Factor; Brain; Cell Membrane; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Heart; Humans; Kidney; Lung; Mice; Mice, Knockout; Natriuretic Peptide, Brain; Neprilysin | 2004 |
Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Carbon Tetrachloride; Cyclic GMP; Cyclohexanecarboxylic Acids; Cytokines; Endothelin-1; Humans; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Male; Neprilysin; Portal Vein; Protease Inhibitors; Rats; Rats, Wistar; Vascular Resistance | 2005 |