candoxatril has been researched along with thiorphan in 3 studies
| Studies (candoxatril) | Trials (candoxatril) | Recent Studies (post-2010) (candoxatril) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 62 | 29 | 5 | 665 | 50 | 82 |
| Protein | Taxonomy | candoxatril (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goto, A; Hayakawa, H; Hirata, Y; Kangawa, K; Kimura, K; Matsuo, H; Minamino, N; Omata, M; Suzuki, E; Suzuki, Y | 1 |
| Wilkins, MR | 1 |
| Berezin, AE | 1 |
2 review(s) available for candoxatril and thiorphan
| Article | Year |
|---|---|
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan | 1993 |
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease Inhibitors; Pyridines; Thiazepines; Thiorphan | 2004 |
1 other study(ies) available for candoxatril and thiorphan
| Article | Year |
|---|---|
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Base Sequence; Blood Pressure; Desoxycorticosterone; Hypertension; Indans; Male; Molecular Sequence Data; Neprilysin; Polysaccharides; Propionates; Rats; Rats, Wistar; Sodium Chloride; Thiorphan | 1994 |