candoxatril has been researched along with omapatrilat in 8 studies
| Studies (candoxatril) | Trials (candoxatril) | Recent Studies (post-2010) (candoxatril) | Studies (omapatrilat) | Trials (omapatrilat) | Recent Studies (post-2010) (omapatrilat) |
|---|---|---|---|---|---|
| 62 | 29 | 5 | 226 | 33 | 22 |
| Protein | Taxonomy | candoxatril (IC50) | omapatrilat (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.1995 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0083 | |
| Neprilysin | Homo sapiens (human) | 0.0002 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.001 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.0053 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnal, JF; Bayard, F; Castano, C; Darblade, B; Gourdy, P; Maupas, E; Michel, JB; Mugniot, A | 1 |
| Carretero, OA; Liu, YH; Oja-Tebbe, N; Shesely, EG; Xu, J; Yang, F; Yang, XP | 1 |
| Berezin, AE | 1 |
| Dendorfer, A; Dominiak, P; Raasch, W | 1 |
| Jakovski, K; Jovanoska, E; Kostova, E; Maleska, V; Slaninka-Miceska, M; Zafirov, D | 1 |
| Backes, BJ; Ballaron, SJ; Banfor, PN; Cox, BF; Fryer, RM; Lin, CW; Reinhart, GA; Segreti, J; Trevillyan, JM; von Geldern, TW; Widomski, DL | 1 |
| Armstrong, SR; Budman, J; Cheruvu, M; Hegde, LG; Hegde, SS; Hill, CM; Klein, U; Lane, CE; Olsufka, R; Park, T; Renner, T; Sandvik, ER; Thibodeaux, H; Yu, C | 1 |
| Lang, CC; Singh, JS | 1 |
2 review(s) available for candoxatril and omapatrilat
| Article | Year |
|---|---|
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease Inhibitors; Pyridines; Thiazepines; Thiorphan | 2004 |
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond.
Topics: Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Combinations; Heart Failure; Humans; Hypertension; Indans; Natriuretic Peptide, Brain; Neprilysin; Propionates; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Stroke Volume; Tetrazoles; Thiazepines; Valsartan | 2015 |
6 other study(ies) available for candoxatril and omapatrilat
| Article | Year |
|---|---|
Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apolipoproteins E; Arteriosclerosis; Atrial Natriuretic Factor; Body Weight; Bradykinin; Cholesterol; Cholesterol, HDL; Drug Evaluation, Preclinical; Indans; Male; Mice; Mice, Knockout; Neprilysin; Propionates; Protease Inhibitors; Pyridines; Substance P; Thiazepines; Triglycerides | 2001 |
Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Collagen; Disease Models, Animal; Echocardiography; Heart; Heart Failure; Indans; Liver; Lung; Mice; Mice, Knockout; Muscle Cells; Neprilysin; Organ Size; Propionates; Pyridines; Ramipril; Thiazepines; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling | 2004 |
Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Dose-Response Relationship, Drug; Indans; Male; Neprilysin; Norepinephrine; Peptidyl-Dipeptidase A; Propionates; Protease Inhibitors; Pyridines; Ramipril; Rats; Rats, Inbred SHR; Thiazepines | 2005 |
Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Drug Combinations; Enalapril; Hypertension; Indans; Male; Neprilysin; Propionates; Pyridines; Rats; Rats, Inbred SHR; Thiazepines | 2005 |
Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema.
Topics: Aminopeptidases; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hypotension; Indans; Lisinopril; Male; Neprilysin; Peptides; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Thiazepines | 2008 |
Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat.
Topics: Angioedema; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Indans; Male; Neprilysin; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Thiazepines; Valine; Valsartan | 2011 |