candoxatril has been researched along with atrial natriuretic factor in 35 studies
| Studies (candoxatril) | Trials (candoxatril) | Recent Studies (post-2010) (candoxatril) | Studies (atrial natriuretic factor) | Trials (atrial natriuretic factor) | Recent Studies (post-2010) (atrial natriuretic factor) |
|---|---|---|---|---|---|
| 62 | 29 | 5 | 15,455 | 1,105 | 1,760 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 31 (88.57) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Connell, JM; Davidson, G; Jardine, AG; O'Connell, JE | 1 |
| Buckley, MG; MacGregor, GA; Markandu, ND; Sagnella, GA; Singer, DR | 1 |
| Coutie, WJ; Lang, CC; Motwani, JG; Struthers, AD | 1 |
| Bevan, EG; Carmichael, HA; Connell, JM; Davies, DL; Doyle, J; Lorimer, AR; McInnes, GT | 1 |
| Elsner, D; Kromer, EP; Müntze, A; Riegger, GA | 1 |
| Espiner, EA; Frampton, C; Ikram, H; Richards, AM; Wittert, GA; Yandle, TG | 1 |
| Hayakawa, H; Hirata, Y; Kangawa, K; Matsuo, H; Matsuoka, H; Minamino, N; Sugimoto, T; Suzuki, E | 1 |
| Espiner, EA; Frampton, C; Ikram, H; Richards, AM; Wittert, G; Yandle, TG | 1 |
| Coutie, WJ; Lang, CC; Motwani, J; Struthers, AD | 1 |
| Elsner, D; Kahles, HW; Kromer, EP; Riegger, GA | 1 |
| Buckley, MG; MacGregor, GA; Markandu, ND; Miller, MA; Sagnella, GA; Singer, DR | 1 |
| Cussans, N; Espiner, E; Frampton, C; Ikram, H; Richards, M; Sopwith, M; Yandle, T | 1 |
| Ando, S; Butler, GC; Floras, JS; Rahman, MA; Senn, BL | 1 |
| Hayakawa, H; Hirata, Y; Kangawa, K; Matsuo, H; Matsuoka, H; Sugimoto, T; Suzuki, E | 1 |
| Blackwood, A; Buckley, MG; MacGregor, GA; Markandu, ND; Miller, MA; Sagnella, GA; Singer, DR | 1 |
| Barclay, PL; Burnett, JC; Margulies, KB | 1 |
| Angus, RM; McCallum, MJ; Nally, JE; Thomson, NC | 1 |
| Buckley, MG; Freegard, T; MacGregor, GA; Markandu, ND; Singer, DR; Wolfensberger, TJ | 1 |
| Goto, A; Hayakawa, H; Hirata, Y; Kangawa, K; Kimura, K; Matsuo, H; Minamino, N; Omata, M; Suzuki, E; Suzuki, Y | 1 |
| Connell, JM; Davies, DL; Jardine, AG; McQueen, J; O'Connell, JE | 1 |
| Armstrong, R; Finn, WL; Gordon, RD; Klemm, SA; Stowasser, M; Tunny, TJ; Ziesak, MD | 1 |
| Abe, K; Igarashi, Y; Ito, O; Kondo, Y; Kudo, K; Takahashi, N | 1 |
| Allen, MJ; Johnson, HF; Lang, CC; Motwani, JG; Struthers, AD | 1 |
| Crozier, IG; Espiner, EA; Nicholls, MG; Richards, AM; Yandle, TG | 1 |
| Crozier, IG; Espiner, EA; Frampton, C; Ikram, H; Richards, AM; Wittert, GA; Yandle, TG | 1 |
| Doi, H; Kugiyama, K; Matsumura, T; Ohta, Y; Sugiyama, S; Yasue, H | 1 |
| Drummer, C; Gerzer, R; Kentsch, M; Müller-Esch, G; Nötges, A; Otter, W | 1 |
| Buchanan, KD; Coutie, W; McDowell, G; Nicholls, DP; Shaw, C; Struthers, AD | 1 |
| Casley, DJ; Johnston, CI; Yasujima, M; Yoshida, K | 1 |
| Casley, DJ; Johnston, CI; Kanazawa, M; Katopothis, A; Yoshida, K | 1 |
| Dargie, HJ; Newby, DE; Norrie, J; Northridge, DB; Rooney, E | 1 |
| Arnal, JF; Bayard, F; Castano, C; Darblade, B; Gourdy, P; Maupas, E; Michel, JB; Mugniot, A | 1 |
| Haloui, M; Louedec, L; Messika-Zeitoun, D; Michel, JB; Philippe, M | 1 |
| Borgeson, DD; Burnett, JC; Cataliotti, A; Luchner, A; Martin, FL; Redfield, MM; Schirger, JA; Stevens, TL | 1 |
| Jakovski, K; Jovanoska, E; Kostova, E; Maleska, V; Slaninka-Miceska, M; Zafirov, D | 1 |
23 trial(s) available for candoxatril and atrial natriuretic factor
| Article | Year |
|---|---|
Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension.
Topics: Administration, Oral; Adult; Analysis of Variance; Antihypertensive Agents; Atrial Natriuretic Factor; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Natriuresis; Neprilysin; Propionates | 1992 |
Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension?
Topics: Atrial Natriuretic Factor; Cyclic GMP; Female; Humans; Hypertension; Indans; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Sodium, Dietary | 1992 |
Clearance of brain natriuretic peptide in patients with chronic heart failure: indirect evidence for a neutral endopeptidase mechanism but against an atrial natriuretic peptide clearance receptor mechanism.
Topics: Aged; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Heart Failure; Humans; Indans; Male; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates; Protease Inhibitors; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1992 |
Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension.
Topics: Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Middle Aged; Neprilysin; Propionates | 1992 |
Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Renin | 1992 |
Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers.
Topics: Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Humans; Indans; Male; Natriuresis; Neprilysin; Prodrugs; Propionates | 1992 |
Prolonged inhibition of endopeptidase 24.11 in normal man: renal, endocrine and haemodynamic effects.
Topics: Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Circadian Rhythm; Creatinine; Cyclic GMP; Double-Blind Method; Endocrine Glands; Hemodynamics; Humans; Indans; Kidney; Natriuresis; Neprilysin; Propionates; Reference Values; Renin | 1991 |
Influence of candoxatril on plasma brain natriuretic peptide in heart failure.
Topics: Atrial Natriuretic Factor; Brain; Heart Failure; Humans; Indans; Middle Aged; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Propionates | 1991 |
Effects of atriopeptidase inhibitor UK 79300 on left ventricular hydraulic load in patients with congestive heart failure.
Topics: Aorta; Atrial Natriuretic Factor; Heart Failure; Humans; Indans; Middle Aged; Neprilysin; Propionates; Regional Blood Flow; Ventricular Function, Left | 1991 |
Dietary sodium and inhibition of neutral endopeptidase 24.11 in essential hypertension.
Topics: Adult; Aldosterone; Analysis of Variance; Atrial Natriuretic Factor; Blood Pressure; Creatine; Heart Rate; Hematocrit; Humans; Hypertension; Indans; Middle Aged; Neprilysin; Potassium; Propionates; Renin; Sodium; Sodium, Dietary | 1991 |
Inhibition of endopeptidase EC 24.11 in humans. Renal and endocrine effects.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Electrolytes; Humans; Indans; Indenes; Kidney; Male; Neprilysin; Propionates; Renin; Renin-Angiotensin System | 1990 |
Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Atrial Natriuretic Factor; Double-Blind Method; Endothelins; Heart Rate; Hemodynamics; Humans; Indans; Infusions, Intravenous; Male; Neprilysin; Propionates; Sodium Chloride; Sympathetic Nervous System; Vascular Resistance | 1995 |
Hormonal and renal responses to neutral endopeptidase inhibition in normal humans on a low and on a high sodium intake.
Topics: Adult; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diet, Sodium-Restricted; Female; Hematocrit; Hemoglobins; Humans; Indans; Male; Middle Aged; Neprilysin; Potassium; Propionates; Reference Values; Renin; Serum Albumin; Sodium; Sodium, Dietary | 1995 |
No effect of the oral neutral endopeptidase inhibitor candoxatril, on bronchomotor tone and histamine reactivity in asthma.
Topics: Administration, Oral; Adult; Analysis of Variance; Asthma; Atrial Natriuretic Factor; Blood Pressure; Bronchi; Bronchospirometry; Double-Blind Method; Forced Expiratory Volume; Histamine; Humans; Indans; Male; Middle Aged; Neprilysin; Propionates; Pulse | 1994 |
Evidence for a new role of natriuretic peptides: control of intraocular pressure.
Topics: Adult; Atrial Natriuretic Factor; Female; Humans; Indans; Intraocular Pressure; Male; Middle Aged; Neprilysin; Prodrugs; Propionates; Single-Blind Method; Time Factors | 1994 |
Renal and hormonal effects of chronic inhibition of neutral endopeptidase (EC 3.4.24.11) in normal man.
Topics: Adult; Angiotensin II; Atrial Natriuretic Factor; Binding Sites; Blood Platelets; Double-Blind Method; Humans; Indans; Kidney; Male; Middle Aged; Neprilysin; Phenylephrine; Propionates; Reference Values | 1993 |
Inhibition of endopeptidase EC 3.4.24.11 by candoxatril lowered blood pressure and increased urinary but not plasma atrial natriuretic peptide in essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Indans; Male; Middle Aged; Neprilysin; Propionates | 1993 |
Dose-ranging effects of candoxatril on elimination of exogenous atrial natriuretic peptide in chronic heart failure.
Topics: Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Dose-Response Relationship, Drug; Heart Rate; Humans; Indans; Infusions, Intravenous; Male; Middle Aged; Prodrugs; Propionates; Single-Blind Method | 1993 |
Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension.
Topics: Adult; Aged; Angiotensin II; Atrial Natriuretic Factor; Double-Blind Method; Humans; Hypertension; Indans; Male; Methionine; Middle Aged; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Posture; Propionates; Time Factors | 1993 |
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II.
Topics: Adult; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Heart Rate; Humans; Hypertension; Indans; Kidney; Male; Middle Aged; Natriuresis; Neprilysin; Propionates; Time Factors | 1993 |
Neutral endopeptidase 24.11 inhibition may not exhibit beneficial haemodynamic effects in patients with congestive heart failure.
Topics: Aldosterone; Atrial Natriuretic Factor; Cyclic AMP; Double-Blind Method; Heart Failure; Hemodynamics; Humans; Indans; Middle Aged; Neprilysin; Propionates; Protease Inhibitors | 1996 |
The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides.
Topics: Aged; Analysis of Variance; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Cross-Over Studies; Double-Blind Method; Endothelins; Heart Failure; Humans; Indans; Male; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Prodrugs; Propionates; Protease Inhibitors | 1997 |
Comparison of the short-term effects of candoxatril, an orally active neutral endopeptidase inhibitor, and frusemide in the treatment of patients with chronic heart failure.
Topics: Atrial Natriuretic Factor; Chronic Disease; Diuretics; Double-Blind Method; Exercise Test; Furosemide; Heart Failure; Humans; Indans; Male; Middle Aged; Propionates; Protease Inhibitors; Renin; Severity of Illness Index; Time Factors | 1999 |
12 other study(ies) available for candoxatril and atrial natriuretic factor
| Article | Year |
|---|---|
Characterization of atrial natriuretic peptide in urine from rats treated with a neutral endopeptidase inhibitor.
Topics: Analysis of Variance; Animals; Atrial Natriuretic Factor; Blood Pressure; Chromatography, Gel; Chromatography, High Pressure Liquid; Indans; Natriuresis; Neprilysin; Propionates; Radioimmunoassay; Rats; Rats, Inbred Strains; Sodium, Dietary | 1992 |
Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Indans; Natriuresis; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Peptide Fragments; Propionates; Rats; Rats, Inbred Strains; Sodium, Dietary | 1994 |
The role of neutral endopeptidase in dogs with evolving congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Dogs; Heart Failure; Hemodynamics; Indans; Kidney; Male; Natriuresis; Neprilysin; Propionates; Sodium; Time Factors | 1995 |
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Base Sequence; Blood Pressure; Desoxycorticosterone; Hypertension; Indans; Male; Molecular Sequence Data; Neprilysin; Polysaccharides; Propionates; Rats; Rats, Wistar; Sodium Chloride; Thiorphan | 1994 |
Lack of direct action of atriopeptidase inhibitor on cellular pH regulation in rabbit S2 proximal straight tubules.
Topics: Animals; Atrial Natriuretic Factor; Diuretics; Female; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; In Vitro Techniques; Indans; Kidney Tubules, Proximal; Neprilysin; Perfusion; Propionates; Rabbits | 1993 |
Suppression of atherosclerotic changes in cholesterol-fed rabbits treated with an oral inhibitor of neutral endopeptidase 24.11 (EC 3.4.24.11).
Topics: Administration, Oral; Animals; Aorta, Thoracic; Arteriosclerosis; Atrial Natriuretic Factor; Body Weight; Cholesterol, Dietary; Diet, Atherogenic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glycopeptides; Hemodynamics; Hypercholesterolemia; Indans; Lipids; Male; Natriuretic Peptide, C-Type; Neprilysin; Nitroprusside; Organ Culture Techniques; Propionates; Proteins; Rabbits; Substance P; Vasodilation | 1996 |
Effect of chronic neutral endopeptidase inhibition on cardiac hypertrophy after experimental myocardial infarction.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Cardiomegaly; Drug Evaluation, Preclinical; Hemodynamics; Indans; Kidney; Male; Myocardial Infarction; Myocardium; Neprilysin; Propionates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 1998 |
Inhibition of kidney neutral endopeptidase after administration of the neutral endopeptidase inhibitor candoxatril: quantitation by autoradiography.
Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Indans; Kidney; Male; Neprilysin; Phenols; Phenylalanine; Propionates; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apolipoproteins E; Arteriosclerosis; Atrial Natriuretic Factor; Body Weight; Bradykinin; Cholesterol; Cholesterol, HDL; Drug Evaluation, Preclinical; Indans; Male; Mice; Mice, Knockout; Neprilysin; Propionates; Protease Inhibitors; Pyridines; Substance P; Thiazepines; Triglycerides | 2001 |
Potentiation of urinary atrial natriuretic peptide interferes with macula densa function.
Topics: Animals; Atrial Natriuretic Factor; Bumetanide; Chlorides; Cyclic GMP; Diuresis; Epithelial Cells; Indans; Kidney Tubules, Distal; Male; NADPH Dehydrogenase; Neprilysin; Nitric Oxide Synthase; Potassium; Propionates; Proteins; Rats; Rats, Wistar; Renin-Angiotensin System; Sodium; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2001 |
Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure.
Topics: Administration, Oral; Aldosterone; Animals; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dogs; Heart; Heart Failure; Indans; Kidney; Male; Mineralocorticoid Receptor Antagonists; Natriuresis; Neprilysin; Propionates; Protease Inhibitors | 2005 |
Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Drug Combinations; Enalapril; Hypertension; Indans; Male; Neprilysin; Propionates; Pyridines; Rats; Rats, Inbred SHR; Thiazepines | 2005 |