candesartan cilexetil has been researched along with candesartan in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (52.78) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Furukawa, Y; Inada, Y; Kato, T; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Shibouta, Y; Yoshimura, Y | 1 |
| Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR | 1 |
| Funakoshi, J; Kakumoto, M; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y | 1 |
| Schieffer, B; Schmidt, B | 1 |
| Giridhar, R; Murumkar, P; Naik, P; Yadav, MR | 1 |
| Gust, R; Obexer, P; Salcher, S; Schoepf, AM | 1 |
| Düsing, R; Feltkamp, H; Flesch, M; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| Inada, Y; Kubo, K; Naka, T; Nishikawa, K; Ojima, M; Shibouta, Y; Wada, T | 1 |
| Inada, Y; Nishikawa, K; Shibouta, Y; Wada, T | 1 |
| Inada, Y; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Naka, T | 1 |
| Inada, Y; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Düsing, R; el-Haschimi, K; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| el-Haschimi, K; Epping, P; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| Belz, GG; Breithaupt-Grögler, K; Butzer, R; Fuchs, B; Herrmann, V; Högemann, A; Magin, SG; Malerczyk, C; Mutschler, E; Roll, S; Voith, B | 1 |
| Heemann, U; Philipp, T | 1 |
| Morsing, P | 1 |
| Buter, H; de Jong, PE; de Zeeuw, D; Navis, GY; Woittiez, AJ | 1 |
| Inada, Y; Kanehara, H; Miyazaki, M; Shiota, N; Song, K; Takai, S; Wada, T | 1 |
| Andersen, C; Lagerström, PO; Stenhoff, H | 1 |
| Riegger, GA | 1 |
| Inada, Y; Nishikawa, K; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Badguet, JP; Mallion, JM | 1 |
| Gleiter, CH; Mörike, KE | 1 |
| Ostergren, J | 1 |
| Koyabu, N; Kuwano, M; Murakami, H; Nakamura, T; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Uchiumi, T; Ushigome, F; Yamashita, F | 1 |
| Hashimoto, T; Imai, N; Kawana, I; Kihara, M; Kitamura, H; Umemura, S; Yazawa, T; Yoshida, S | 1 |
| Kamiyama, E; Mikkaichi, T; Nakai, D; Okazaki, O; Okudaira, N | 1 |
| Bu, H; Gao, F; Gao, Z; Huang, Y; Li, Y; Shen, J; Zhang, Z; Zhao, C | 1 |
| Fu, H; Hosomi, N; Itano, T; Kohno, M; Liu, G; Masugata, H; Matsumoto, M; Miki, T; Nakano, D; Nishiyama, A; Pelisch, N; Sueda, Y; Ueno, M | 1 |
| Bharathi, DV; Chatki, PK; Hotha, KK; Satyanarayana, V; Venkateswarlu, V | 1 |
| Afantitis, A; Baldus, J; Christodouleas, D; Fotakis, C; Glaubitz, C; Hodzic, A; Kritsi, E; Mali, G; Mavromoustakos, T; Megariotis, G; Melagraki, G; Ntountaniotis, D; Pabst, G; Papadopoulos, MG; Potamitis, C; Rappolt, M; Zervou, M; Zoumpoulakis, P | 1 |
| Fukuda, H; Nakanishi, T; Tamai, I | 1 |
| Cha, G; Gil-Extremera, B; Haller, H; Harvey, P; Heyvaert, F; Kjeldsen, SE; Lewin, AJ; Mancia, G; Sica, D; Villa, G | 1 |
| Allen, TJ; Chow, BS; Cooper, ME; Jandeleit-Dahm, KA; Koulis, C; Krishnaswamy, P; Steckelings, UM; Unger, T | 1 |
11 review(s) available for candesartan cilexetil and candesartan
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship | 1996 |
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2 | 2003 |
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan | 2010 |
[Nonpeptide angiotensin II-receptor antagonists].
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Disease Models, Animal; Prodrugs; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1994 |
[Angiotensin II receptor antagonist activities and mode of action of benzimidazole-7-carboxylic acid derivatives].
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Prodrugs; Structure-Activity Relationship; Tetrazoles | 1993 |
Clinical efficacy of a new AT1 blocker.
Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Prodrugs; Tetrazoles | 1998 |
Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Irbesartan; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
[ACE inhibitors or AT1 receptor antagonists?].
Topics: Age Factors; Aged; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Clinical Trials as Topic; Death, Sudden, Cardiac; Enalapril; Heart Failure; Humans; Losartan; Prodrugs; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Time Factors | 1999 |
Putting the efficacy of candesartan cilexetil into perspective: a review of new comparative data.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Cerebellum; Circadian Rhythm; Female; Heart; Humans; Hypertension; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Middle Aged; Prodrugs; Rabbits; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin; Tetrazoles; Time Factors | 2000 |
Clinical pharmacokinetics of candesartan.
Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biological Availability; Biphenyl Compounds; Blood Proteins; Humans; Intestinal Absorption; Kidney Diseases; Prodrugs; Receptor, Angiotensin, Type 1; Tetrazoles; Tissue Distribution | 2002 |
Candesartan for the treatment of hypertension and heart failure.
Topics: Administration, Oral; Benzimidazoles; Biphenyl Compounds; Diabetes Mellitus; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Failure; Humans; Hypertension; Male; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Tetrazoles; Tissue Distribution; Treatment Outcome; Ventricular Function, Left | 2004 |
3 trial(s) available for candesartan cilexetil and candesartan
| Article | Year |
|---|---|
Angiotensin II antagonism and plasma radioreceptor-kinetics of candesartan in man.
Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Male; Prodrugs; Rats; Receptors, Angiotensin; Tetrazoles | 1998 |
Pharmacokinetics and pharmacodynamics of candesartan cilexetil in patients with normal to severely impaired renal function.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Kidney; Kidney Diseases; Male; Middle Aged; Prodrugs; Renin; Tetrazoles | 1999 |
Nifedipine plus candesartan combination increases blood pressure control regardless of race and improves the side effect profile: DISTINCT randomized trial results.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Tetrazoles; Treatment Outcome | 2014 |
22 other study(ies) available for candesartan cilexetil and candesartan
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biological Availability; Biphenyl Compounds; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Interaction of digoxin with antihypertensive drugs via MDR1.
Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Drug Interactions; Humans; Time Factors | 2002 |
Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.
Topics: Animals; Cell Death; Cell Proliferation; Chlorocebus aethiops; COS Cells; Drug Design; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; PPAR gamma; Structure-Activity Relationship; Telmisartan | 2020 |
Effects of TCV-116 and CV-11974 on angiotensin II-induced responses in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Tetrazoles | 1995 |
Angiotensin II Receptor Antagonists: Can they Go Beyond ACE Inhibitors? Proceedings of a satellite symposium to the 15th scientific meeting of the International Society of Hypertension. Melbourne, Australia, March 1994.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Tetrazoles | 1994 |
Pharmacological profile of a novel nonpeptide angiotensin II subtype 1 receptor antagonist, TCV-116.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cough; Disease Models, Animal; Guinea Pigs; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Renin; Tetrazoles | 1994 |
Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Corticosterone; Hypertension; Imidazoles; Infusions, Intravenous; Male; Pyridines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Tetrazoles; Zona Glomerulosa | 1994 |
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethy
Topics: Adrenal Cortex; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles | 1993 |
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Becaplermin; Benzimidazoles; Biphenyl Compounds; Cell Division; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Tetrazoles | 1996 |
Carbocyclic thromboxane A2 enhances the angiotensin II-induced DNA synthesis in smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred WKY; RNA, Messenger; Tetrazoles; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Inhibition of the angiotensin II Type 1 receptor by TCV-116: quantitation by in vitro autoradiography.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1999 |
Determination of candesartan cilexetil, candesartan and a metabolite in human plasma and urine by liquid chromatography and fluorometric detection.
Topics: Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Chromatography, Liquid; Humans; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Tetrazoles | 1999 |
Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bradykinin; Enalapril; Enzyme Activation; Hypertension, Renal; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Surgical Instruments; Tetrazoles; Vasoconstrictor Agents | 1996 |
Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
Topics: Acetates; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biological Transport; Biphenyl Compounds; Blotting, Western; Cell Line; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Estrone; Humans; Imidazoles; Indoles; Leukotriene Antagonists; Losartan; Molecular Structure; Organic Anion Transporters, Sodium-Independent; Phenylcarbamates; Quinolines; Structure-Activity Relationship; Sulfides; Sulfonamides; Tetrazoles; Tosyl Compounds; Transfection; Tritium; Valine; Valsartan | 2006 |
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Carcinoma, Lewis Lung; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Radioimmunoassay; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrazoles; Vascular Endothelial Growth Factor A | 2007 |
Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.
Topics: Adenosine Triphosphatases; Angiotensin II Type 1 Receptor Blockers; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzoates; Biological Transport; Biphenyl Compounds; Caco-2 Cells; Calcium Channel Blockers; Cardiotonic Agents; Cell Membrane; Digoxin; Drug Interactions; Humans; Irbesartan; Losartan; Telmisartan; Tetrazoles; Verapamil | 2010 |
Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism.
Topics: Animals; Benzimidazoles; Biological Availability; Biological Transport; Biphenyl Compounds; Caco-2 Cells; Chromatography, High Pressure Liquid; Drug Carriers; Duodenum; Emulsions; Endocytosis; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Microscopy, Electron, Transmission; Mouth Mucosa; Nanostructures; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility; Surface Properties; Tandem Mass Spectrometry; Tetrazoles | 2011 |
Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Brain Edema; Brain Ischemia; Hypotension; Ischemia; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 2011 |
LC-MS/MS method for simultaneous estimation of candesartan and hydrochlorothiazide in human plasma and its use in clinical pharmacokinetics.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Humans; Hydrochlorothiazide; Liquid-Liquid Extraction; Statistics, Nonparametric; Tandem Mass Spectrometry; Tetrazoles | 2012 |
Comparative study of the AT₁ receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Cell Membrane; Imidazoles; Lipid Bilayers; Molecular Conformation; Receptor, Angiotensin, Type 1; Tetrazoles; Thermodynamics; Valine; Valsartan | 2012 |
More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cholestasis; Drug Interactions; Hepatocytes; Humans; Prodrugs; Tetrazoles; Tissue Culture Techniques | 2014 |
The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Apolipoproteins E; Atherosclerosis; Benzimidazoles; Biphenyl Compounds; Cell Line; Diabetes Mellitus, Experimental; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 2; Sulfonamides; Tetrazoles; Thiophenes | 2016 |