candesartan and eplerenone

candesartan has been researched along with eplerenone in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Fakouhi, K; He, W; Krause, S; Krum, H; Nolly, H; Roniker, B; Workman, D1
Omura, T; Yoshikawa, J; Yoshiyama, M1
Hirata, Y; Hirono, Y; Kobayashi, N; Sakurada, M; Shichiri, M; Sugiyama, T; Suzuki, N; Takai, S; Yoshimoto, T1
Takata, H; Takeda, Y; Usukura, M; Yamagishi, M; Yoneda, T; Zhu, A1
Kushibiki, M; Okumura, K; Osanai, T; Tomita, H; Yamada, M1
Homma, I; Iigaya, K; Kobayashi, Y; Minoura, Y; Onimaru, H1
Gutiérrez Solís, E; Gutiérrez, E; Huerta, A; Morales, E; Praga, M; Segura, J1
Frohlich, ED; Susic, D; Varagic, J1
Ariti, CA; Collier, TJ; Pocock, SJ; Wang, D1
Cheng, Y; Demura, M; Karashima, S; Takata, H; Takeda, Y; Yagi, K; Yamagishi, M; Yoneda, T; Zhu, A1
Gabor, A; Leenen, FH1
Amann, K; Brand, S; Mandel, P; Schupp, N; Zimnol, A1
Goto, M; Hasebe, N; Takahashi, F; Wada, Y1

Reviews

2 review(s) available for candesartan and eplerenone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Additive improvement of left ventricular remodeling by aldosterone receptor blockade with eplerenone and angiotensin II type 1 receptor antagonist in rats with myocardial infarction.
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2004, Volume: 124, Issue:2

    Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Eplerenone; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Rats; Spironolactone; Tetrazoles; Ventricular Dysfunction, Left; Ventricular Remodeling

2004

Trials

2 trial(s) available for candesartan and eplerenone

ArticleYear
Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Eplerenone; Female; Headache; Heart Rate; Humans; Hypertension; Irbesartan; Losartan; Male; Middle Aged; Patient Dropouts; Renin-Angiotensin System; Spironolactone; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2002
[The antiproteinuric effect of the blockage of the renin-angiotensin-aldosterone system (RAAS) in obese patients. Which treatment option is the most effective? ].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2009, Volume: 29, Issue:5

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Eplerenone; Female; Humans; Lisinopril; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Obesity; Prospective Studies; Proteinuria; Spironolactone; Tetrazoles

2009

Other Studies

10 other study(ies) available for candesartan and eplerenone

ArticleYear
Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system.
    Endocrinology, 2007, Volume: 148, Issue:4

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Vessels; Cyclic N-Oxides; Eplerenone; Gene Expression Regulation; Hypertension; Inflammation Mediators; Male; Models, Biological; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Spin Labels; Spironolactone; Tetrazoles

2007
Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.
    American journal of hypertension, 2007, Volume: 20, Issue:10

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Endothelium, Vascular; Eplerenone; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Spironolactone; Tetrazoles

2007
Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization.
    Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Dimerization; Eplerenone; Male; Mesentery; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Receptor, Angiotensin, Type 1; Spironolactone; Tetrazoles; Transglutaminases; Valine; Valsartan; Vasoconstriction; Vasodilation

2008
Electrophysiological responses of sympathetic preganglionic neurons to ANG II and aldosterone.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:3

    Topics: Aldosterone; Anesthetics, Local; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Fibers, Preganglionic; Benzimidazoles; Biphenyl Compounds; Eplerenone; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Spironolactone; Synaptic Transmission; Tetrazoles; Tetrodotoxin; Time Factors

2009
Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomyopathies; Cardiovascular System; Eplerenone; Hypertension; Hypertrophy; Kidney; Male; Mineralocorticoid Receptor Antagonists; Quinapril; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Regional Blood Flow; Renin-Angiotensin System; Sodium Chloride, Dietary; Spironolactone; Tetrahydroisoquinolines; Tetrazoles; Ventricular Dysfunction, Left

2010
The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities.
    European heart journal, 2012, Volume: 33, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Aortic Valve Stenosis; Benzimidazoles; Biphenyl Compounds; Cardiac Catheterization; Cardiovascular Diseases; Clinical Trials as Topic; Endpoint Determination; Eplerenone; Heart Failure; Hospitalization; Humans; Matched-Pair Analysis; Mineralocorticoid Receptor Antagonists; Proportional Hazards Models; Risk Factors; Spironolactone; Tetrazoles

2012
Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats.
    Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eplerenone; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Peripheral Nerves; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Tetrazoles

2012
Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension.
    Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:5

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Eplerenone; Glutamic Acid; Heart Rate; Hypertension; Infusions, Intravenous; Infusions, Intraventricular; Kynurenic Acid; Male; Mineralocorticoid Receptor Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Glutamate; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Tetrazoles

2013
Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; DNA Damage; DNA Repair; Enzyme Activation; Eplerenone; Guanosine; Heart; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Spin Labels; Spironolactone; Tetrazoles

2014
Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:19

    Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Creatinine; Drug Therapy, Combination; Eplerenone; Heart Failure; Humans; Hypertension, Malignant; Male; Nifedipine; Nitroglycerin; Obesity; Renal Insufficiency; Spironolactone; Tetrazoles; Treatment Outcome; Vasodilator Agents

2015