canavanine and bosutinib

canavanine has been researched along with bosutinib* in 1 studies

Other Studies

1 other study(ies) available for canavanine and bosutinib

Article	Year
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heterocycle amine-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, synthesized and evaluated as multiple targets agents in cancer therapy. All compounds were evaluated by two related enzyme inhibition assays and an anti-proliferation assay in vitro. The results showed that most compounds inhibited c-Src and iNOS well. The best compound 8 inhibited both enzymes with the IC(50) values of 34.8 nM and 26.7 microM. Several compounds also showed moderate anti-proliferation at 10 microM against colon and liver cancer cell lines. Topics: Aniline Compounds; Antineoplastic Agents; CSK Tyrosine-Protein Kinase; Drug Design; HT29 Cells; Humans; Molecular Structure; Nitric Oxide Synthase Type II; Nitriles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinolines; src-Family Kinases; Structure-Activity Relationship	2008

Article

Year

The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS.

Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heterocycle amine-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, synthesized and evaluated as multiple targets agents in cancer therapy. All compounds were evaluated by two related enzyme inhibition assays and an anti-proliferation assay in vitro. The results showed that most compounds inhibited c-Src and iNOS well. The best compound 8 inhibited both enzymes with the IC(50) values of 34.8 nM and 26.7 microM. Several compounds also showed moderate anti-proliferation at 10 microM against colon and liver cancer cell lines.

Topics: Aniline Compounds; Antineoplastic Agents; CSK Tyrosine-Protein Kinase; Drug Design; HT29 Cells; Humans; Molecular Structure; Nitric Oxide Synthase Type II; Nitriles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinolines; src-Family Kinases; Structure-Activity Relationship

2008