camptothecin and wortmannin

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

Topics: Antigens, Surface; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Glutamate Carboxypeptidase II; Glutarates; Humans; Ligands; Male; Molecular Targeted Therapy; Prodrugs; Prostatic Neoplasms; Structure-Activity Relationship; Urea

Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Chalcogens; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Structure-Activity Relationship

Topics: Alkaloids; Androstadienes; Antigens, Nuclear; Ataxia Telangiectasia; Camptothecin; Cell Cycle; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Ku Autoantigen; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Staurosporine; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Antigens, Polyomavirus Transforming; Camptothecin; Cytoplasm; DNA Damage; DNA Replication; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Viral; Enzyme Inhibitors; HeLa Cells; Humans; Kinetics; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Simian virus 40; Wortmannin; X-Rays

Topics: Acetylation; Androstadienes; Camptothecin; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deoxyribonuclease I; DNA; DNA Damage; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Wortmannin

Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin

Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; DNA Damage; DNA Replication; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; HeLa Cells; Humans; Mutation; Nuclear Proteins; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Tumor Suppressor Proteins; Wortmannin

Topics: Androstadienes; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Camptothecin; Cell Survival; CHO Cells; Cricetinae; Dioxoles; DNA; DNA Repair; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoquinolines; Nuclear Proteins; Protein Serine-Threonine Kinases; Tetrahydroisoquinolines; Trabectedin; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Oligonucleotide Array Sequence Analysis; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Base Sequence; Benzaldehydes; Caffeine; Camptothecin; Cell Line, Tumor; DNA Damage; DNA Repair; Green Fluorescent Proteins; Humans; Luminescent Proteins; Molecular Sequence Data; Oligonucleotides; Recombination, Genetic; Wortmannin

Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Camptothecin; Caspase 3; Caspase Inhibitors; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Humans; Insulin; Insulin Receptor Substrate Proteins; Kidney Tubules; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Wortmannin

Topics: Adolescent; Androstadienes; Antigens, Ly; Apoptosis; Bone and Bones; Camptothecin; Cell Line; Cell Survival; Cells, Cultured; Child; Enzyme Inhibitors; Female; Fibroblasts; Gingiva; Humans; Immunoblotting; In Situ Nick-End Labeling; Keratinocytes; Male; Mouth Mucosa; Periodontal Ligament; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Topoisomerase I Inhibitors; Urokinase-Type Plasminogen Activator; Wortmannin

Topics: Androstadienes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Irinotecan; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Topotecan; Wortmannin

Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Benzamides; Camptothecin; Cell Proliferation; Cells, Cultured; Cisplatin; Drug Resistance; Etoposide; Fluorescent Antibody Technique; Gene Expression; Humans; Hyaluronan Receptors; Imatinib Mesylate; Integrin alpha6; Keratinocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Primary Cell Culture; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Tumor Suppressor Proteins; Ultraviolet Rays; Wortmannin