camptothecin has been researched along with tyrosine in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bjornsti, MA; Fertala, J; Knab, AM | 2 |
| Lumelsky, NL; Schwartz, BS | 1 |
| Bjornsti, MA; Fertala, J; Megonigal, MD | 1 |
| Champoux, JJ; Hol, WG; Kuhn, P; Redinbo, MR; Stewart, L | 1 |
| Jaso-Friedmann, L; Leary, JH; Ruiz, J | 1 |
| Boyd, G; Burchell, B; Cummings, J; Ethell, BT; Jodrell, DI; Macpherson, JS; Smyth, JF | 1 |
| Balazs, L; Deng, W; Johnson, LR; Tigyi, G; Van Middlesworth, L; Wang, DA | 1 |
| Ando, M; Hanioka, N; Ishida, S; Jinno, H; Nishimura, T; Ozawa, S; Saeki, M; Saito, Y; Sawada, J; Tanaka-Kagawa, T | 1 |
| Chen, Z; Fesik, S; Gunasekera, AH; Rosenberg, SH; Sowin, TJ; Xiao, Z; Zhang, H | 1 |
| Benedetti, P; Bruselles, A; Chillemi, G; Desideri, A; Falconi, M; Fiorani, P | 1 |
| Allen, JD; Boyd, G; Cummings, J; Friedberg, TH; Jodrell, DI; Maliepaard, M; Smyth, JF; Yao, D; Zelcer, N | 1 |
| Boyd, G; Burchell, B; Cummings, J; Ethell, BT; Jardine, L; Jodrell, DI; Macpherson, JS; Smyth, JF | 1 |
| Bjornsti, MA; Burgin, AB; Colley, WC; van der Merwe, M; Vance, JR | 1 |
| Kishida, O; Kiyohara, T; Miyazaki, T; Miyazaki, Y; Murayama, Y; Ogasa, M; Shimomura, I; Shinomura, Y; Tsutsui, S; Watabe, K; Yamamoto, T | 1 |
| Choudhury, AK; Dedkova, L; Gao, R; Hecht, SM; Rahier, NJ; Zhang, Y | 1 |
| Gotwald, T; Hutterer, M; Jacobs, AH; Kostron, H; Muigg, A; Nowosielski, M; Putzer, D; Staffen, W; Stockhammer, G; Tinkhauser, G; Trinka, E; Virgolini, IJ; Waitz, D | 1 |
| Blaum, M; Galldiks, N; Heinzel, A; Langen, KJ; Mottaghy, FM; Müller, D; Verburg, FA | 1 |
| Kjaer, A; Kristoffersen, K; Lassen, U; Madsen, J; Michaelsen, SR; Nedergaard, MK; Poulsen, HS; Stockhausen, MT | 1 |
| Iwai, S; Kuraoka, I; Masuda, Y; Takahata, C; Takedachi, A; Tanaka, K | 1 |
| Aluri, R; Jayakannan, M | 1 |
| Artali, R; Bianchino, E; Cardile, F; Cincinelli, R; Colelli, F; Dallavalle, S; Guglielmi, M; Musso, L; Pisano, C | 1 |
| Aluri, R; Jayakannan, M; Joshi, DC; Saxena, S | 1 |
| Adachi, S; Anai, H; Hanada, K; Ishizaki, T; Kawano, M; Matsuoka, S; Nishida, M; Nishida, Y; Okuma, T; Tanaka, K; Terabayashi, T; Tomo, T; Tsumura, H | 1 |
24 other study(ies) available for camptothecin and tyrosine
| Article | Year |
|---|---|
A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons.
Topics: Alanine; Arginine; Base Sequence; Binding Sites; Camptothecin; Cloning, Molecular; DNA; DNA Topoisomerases, Type I; Drug Resistance; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Tyrosine | 1995 |
Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants.
Topics: Amino Acid Sequence; Base Sequence; Camptothecin; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; DNA Topoisomerases, Type I; Drug Resistance, Microbial; Durapatite; Humans; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Point Mutation; Restriction Mapping; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1993 |
Protease inhibitors induce specific changes in protein tyrosine phosphorylation that correlate with inhibition of apoptosis in myeloid cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; DNA, Neoplasm; HL-60 Cells; Humans; Nucleosomes; Phosphoric Monoester Hydrolases; Phosphorylation; Protease Inhibitors; Topoisomerase I Inhibitors; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine | 1996 |
Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death.
Topics: Apoptosis; Binding Sites; Camptothecin; Cell Cycle; DNA Damage; DNA Topoisomerases, Type I; G2 Phase; Kinetics; Mutagenesis, Site-Directed; Phenotype; Saccharomyces cerevisiae; Structure-Activity Relationship; Tyrosine | 1997 |
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Topics: Antineoplastic Agents, Phytogenic; Binding Sites; Camptothecin; Crystallography, X-Ray; DNA; DNA Topoisomerases, Type I; DNA-Binding Proteins; Homeodomain Proteins; Host Cell Factor C1; Humans; Hydrogen Bonding; Integrases; Models, Molecular; Mutation; Nucleic Acid Conformation; Octamer Transcription Factor-1; Oligodeoxyribonucleotides; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Transcription Factors; Tyrosine | 1998 |
Phosphorylation-induced activation of tilapia nonspecific cytotoxic cells by serum cytokines.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Benzoquinones; Blotting, Western; Camptothecin; Cell Cycle; Cold Temperature; Cytokines; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Female; Flow Cytometry; Killer Cells, Natural; Kinetics; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Stress, Physiological; Tilapia; Tyrosine; Vanadates | 2001 |
Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation.
Topics: Anthraquinones; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Glucuronates; Glucuronides; HT29 Cells; Humans; Irinotecan; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolic Clearance Rate; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine | 2002 |
Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; DNA Fragmentation; Enzyme Activation; ErbB Receptors; Gamma Rays; GTP-Binding Proteins; Intestinal Mucosa; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Phosphorylation; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; rho GTP-Binding Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D.
Topics: Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Camptothecin; Chlorocebus aethiops; COS Cells; Genetic Variation; Glucuronides; Glucuronosyltransferase; Glutamine; Glycine; Humans; Irinotecan; Proline; Tyrosine | 2003 |
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Camptothecin; cdc25 Phosphatases; Cell Cycle; Cell Separation; Checkpoint Kinase 1; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Phosphorylation; Protein Kinases; RNA, Small Interfering; S Phase; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Ultraviolet Rays | 2003 |
Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.
Topics: Alanine; Binding Sites; Camptothecin; Catalysis; Cell Survival; DNA; DNA Topoisomerases, Type I; Drug Resistance; Enzyme Inhibitors; Humans; Ions; Kinetics; Models, Molecular; Mutation; Oligonucleotides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Time Factors; Tyrosine | 2003 |
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.
Topics: Anthraquinones; Antigens, CD; Antineoplastic Agents, Phytogenic; Biological Transport; Camptothecin; Carrier Proteins; Colonic Neoplasms; Drug Interactions; Drug Resistance; Glucuronides; HT29 Cells; Humans; Irinotecan; Membrane Glycoproteins; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Tetraspanin 29; Tumor Cells, Cultured; Tyrosine | 2004 |
Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
Topics: Anthraquinones; Biopsy; Camptothecin; Catalysis; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Food Additives; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Isoenzymes; Propofol; Topoisomerase I Inhibitors; Tyrosine | 2003 |
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.
Topics: Asparagine; Binding Sites; Camptothecin; Conserved Sequence; DNA; DNA Topoisomerases, Type I; DNA, Superhelical; Enzyme Inhibitors; Histidine; Mutagenesis; Phenylalanine; Saccharomyces cerevisiae; Structure-Activity Relationship; Tyrosine | 2004 |
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
Topics: Amphiregulin; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Irinotecan; Phosphorylation; Quinazolines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Transforming Growth Factor alpha; Tyrosine | 2005 |
Effects of modification of the active site tyrosine of human DNA topoisomerase I.
Topics: Binding Sites; Camptothecin; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Topoisomerase I Inhibitors; Tyrosine | 2006 |
O-(2-18F-fluoroethyl)-L-tyrosine PET predicts failure of antiangiogenic treatment in patients with recurrent high-grade glioma.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Astrocytoma; Bevacizumab; Brain Neoplasms; Camptothecin; Combined Modality Therapy; Disease-Free Survival; Female; Glioma; Humans; Image Processing, Computer-Assisted; Irinotecan; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Diseases; Positron-Emission Tomography; Postoperative Complications; Predictive Value of Tests; Radiopharmaceuticals; Retrospective Studies; Survival Analysis; Treatment Failure; Tyrosine; Ultrasonography | 2011 |
The use of O-(2-18F-fluoroethyl)-L-tyrosine PET for treatment management of bevacizumab and irinotecan in patients with recurrent high-grade glioma: a cost-effectiveness analysis.
Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Camptothecin; Cost-Benefit Analysis; Decision Trees; Disease-Free Survival; Glioma; Humans; Irinotecan; Magnetic Resonance Imaging; Monte Carlo Method; Neoplasm Grading; Positron-Emission Tomography; Recurrence; Treatment Outcome; Tyrosine | 2013 |
The use of longitudinal 18F-FET MicroPET imaging to evaluate response to irinotecan in orthotopic human glioblastoma multiforme xenografts.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Female; Glioblastoma; Heterografts; Humans; Irinotecan; Mice, Nude; Neuroimaging; Positron-Emission Tomography; Tyrosine | 2014 |
Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex.
Topics: Camptothecin; DNA; DNA Breaks, Single-Stranded; DNA Damage; DNA Ligase ATP; DNA Ligases; DNA Repair; DNA Topoisomerases, Type I; DNA-Binding Proteins; Endonucleases; Flap Endonucleases; HeLa Cells; Humans; Recombinant Proteins; Replication Protein A; Tyrosine | 2015 |
Development of l-Tyrosine-Based Enzyme-Responsive Amphiphilic Poly(ester-urethane) Nanocarriers for Multiple Drug Delivery to Cancer Cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Camptothecin; Cell Survival; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Polyesters; Polymers; Polyurethanes; Tyrosine | 2017 |
Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Cells, Cultured; Disulfides; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tyrosine | 2018 |
Multistimuli-Responsive Amphiphilic Poly(ester-urethane) Nanoassemblies Based on l-Tyrosine for Intracellular Drug Delivery to Cancer Cells.
Topics: Animals; Camptothecin; Doxorubicin; Drug Delivery Systems; Endocytosis; HeLa Cells; Humans; Lysosomes; MCF-7 Cells; Mice; Nanoparticles; Neoplasms; Polyesters; Polyurethanes; Tyrosine | 2018 |
Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition.
Topics: Aphidicolin; Arginine; Asparagine; Camptothecin; DNA; DNA Topoisomerases, Type I; Naphthyridines; Tyrosine | 2022 |