camptothecin has been researched along with staurosporine in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (24.05) | 18.2507 |
| 2000's | 36 (45.57) | 29.6817 |
| 2010's | 20 (25.32) | 24.3611 |
| 2020's | 4 (5.06) | 2.80 |
| Authors | Studies |
|---|---|
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Adcock, AF; Ayers, S; Carcache de Blanco, EJ; Graf, TN; Kroll, DJ; Matthew, S; Oberlies, NH; Pearce, CJ; Shen, Q; Swanson, SM; Wani, MC | 1 |
| Cetin Atalay, R; Guven, EB; Onder, T; Tuncbilek, M | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Andreev, EN; D'yakonov, VA; Dzhemilev, UM; Dzhemileva, LU; Makarov, AA; Makarova, EK | 1 |
| Abdelhamid, D; Abuo-Rahma, GEA; Badr, M; Hassan, A; Hassan, HA | 1 |
| Chen, ZS; Li, D; Qiu, Y; Wu, L; Xu, J; Xu, S; Yang, DH; Yao, H; Zhou, M | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Bartus, JO; Clark, MA; Crooke, ST; Foley, JJ; Mattern, MR; Mong, S; Mong, SM; Sarau, HM | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Kameoka, M; Kamiya, T; Kojima, K; Tanaka, Y; Tohno, Y; Yoshihara, K | 1 |
| Bertrand, R; Dubrez, L; Eymin, B; Pommier, Y; Solary, E | 1 |
| Pommier, Y; Shao, RG; Shimizu, T | 1 |
| Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS | 1 |
| Cao, CX; Kohn, KW; O'Connor, PM; Pommier, Y; Shao, RG; Shimizu, T | 1 |
| Cao, CX; Pommier, Y; Shao, RG | 1 |
| Saijo, N | 1 |
| Joshi, B; Li, L; Tang, DG; Zhu, Z | 1 |
| Bernhard, EJ; Janss, AJ; Levow, C; McKenna, WG; Muschel, RJ; Phillips, PC; Sutton, L | 1 |
| Adachi, K; Hirata, Y; Kiuchi, K | 1 |
| Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N | 1 |
| Columbaro, M; Falcieri, E; Ghibellini, D; Gobbi, P; Luchetti, F; Mariani, AR; Vitale, M; Zamai, L; Zauli, G | 1 |
| Al-Rubeai, M; Ishaque, A | 1 |
| Cao, CX; Kohn, KW; Pommier, Y; Shao, RG; Wold, MS; Zhang, H | 1 |
| Nieves-Neira, W; Pommier, Y | 1 |
| Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS | 1 |
| Clements, MK; Daoud, SS; Jones, CB; Wasi, S | 1 |
| Chambers, TC; Drake, RR; Jones, KE; McMasters, RA; Moyer, MP; Pitlyk, K; Saylors, RL; Wilbert, TN | 1 |
| Clements, MK; Daoud, SS; Jones, CB; Redkar, A | 1 |
| Kong, JY; Rabkin, SW | 1 |
| De Jong, AJ; Hoeberichts, FA; Maximova, E; Woltering, EJ; Yakimova, ET | 1 |
| Chen, X; Danes, C; Hall, MJ; Herliczek, T; Keyomarsi, K; Lawrence, DA; Lowe, M | 1 |
| Ogino, T; Okada, S; Omori, M; Than, TA | 1 |
| Binderup, L; Hansen, CM; Hansen, D; Holm, PK | 1 |
| Daoud, SS; Meadows, GG; Redkar, AA | 1 |
| Bendfeldt, K; Bojarski, C; Fromm, M; Gitter, AH; Mankertz, J; Schmitz, H; Schulzke, JD; Wagner, S | 1 |
| Korsmeyer, S; Li, DW; Mao, YW; Reddan, J; Wang, J; Xiang, H | 1 |
| Amstad, PA; Dhawan, S; Johnson, GL; Lee, BW; Phelps, DJ; Yu, G | 1 |
| Bell, B; Scheer, E; Tora, L | 1 |
| Ensor, EA; Kinloch, RA; Latchman, DS; Smith, MD | 1 |
| Chen, Y; Di, C; Han, W; Ma, D; Song, Q; Sun, R; Zhang, Y | 1 |
| Bieszczad, CK; Cleaveland, ES; Craig, RW; Ma, Y; Mohandas, TK; Park, JP; Vrana, JA | 1 |
| Brown, MK; Eastman, A; Kohn, EA; Livingstone, M; Ruth, ND | 1 |
| Alvarez, AM; Boscá, L; Castrillo, A; Hortelano, S; Zeini, M | 1 |
| Kim, EJ; Park, TH; Rhee, WJ | 1 |
| Bozko, P; Larsen, AK; Raymond, E; Skladanowski, A | 1 |
| Chen, TC; Fry, D; Liebes, L; Su, S | 1 |
| Ensor, E; Latchman, DS; Mathews, K; Payne Smith, MD | 1 |
| Daikoku, T; Goshima, F; Nishiyama, Y; Yamauchi, Y | 1 |
| Baran, V; Fabian, D; Koppel, J; Rehak, P | 1 |
| Bates, SE; Blayney, M; Mistry, P; Morisaki, K; Polgar, O; Robey, RW; Steadman, K | 1 |
| Schwartz, GK; Tse, AN | 1 |
| Iadecola, C; Qian, L; Zhou, P | 1 |
| Bresnick, E; Eastman, A; Kohn, EA; Levesque, AA | 1 |
| Favoreel, HW; Geenen, K; Nauwynck, HJ | 1 |
| Braun, T; Carvalho, G; Castedo, M; Coquelle, A; Kroemer, G; Métivier, D; Mouhamad, S; Pequignot, MO; Vivet, S | 1 |
| Bell, CW; Jiang, W; Pisetsky, DS; Reich, CF | 1 |
| Keyomarsi, K; McGahren-Murray, M; Terry, NH | 1 |
| Baker, SD; Carducci, MA; Dancey, J; Donehower, RC; Hidalgo, M; Jimeno, A; Laheru, DA; Messersmith, WA; Purcell, T; Rudek, MA | 1 |
| Aladjem, MI; Conti, C; Pommier, Y; Seiler, JA; Syed, A | 1 |
| Eastman, A; Fanous, AA; Levesque, AA; Poh, A | 1 |
| Cai, M; Chen, L; Chowdhury, D; Gao, M; Lee, DH; Li, J; Liao, J; Pfeifer, GP; Wang, H; Xu, X; Yang, YG; Yen, Y; Zhao, A; Zhong, X | 1 |
| Aleyasin, H; Cregan, SP; Gonzalez, YR; Huang, E; Park, DS; Parsanejad, M; Qu, D; Rousseaux, MW; Slack, RS; Zhang, Y | 1 |
| Arellano, RO; Hernández-Enríquez, B; Morán, J | 1 |
| Li, HL; Liao, K; Liu, R; Liu, SJ; Wang, HH; Wang, JZ; Wang, Q; Zhang, Y | 1 |
| Adkins, DR; Arquette, MA; Cai, SR; Chen, RC; Creekmore, AN; Dancey, J; Ellis, MJ; Fleshman, JW; Fracasso, PM; Goodner, SA; Guo, Z; Lin, L; Ma, CX; McLeod, HL; Naughton, MJ; Picus, J; Piwnica-Worms, H; Pluard, TJ; Rader, JS; Rudek, MA; Ryan, CE; Soares, EM; Tan, BR; Tao, Y; Williams, KJ; Wright, LP | 1 |
| Blain, SW; Ye, W | 1 |
| Burke, SJ; Campagna, SR; Collier, JJ; Eisenhauer, ME; Frydman, CJ; Lu, D; Sapp, RC | 1 |
| Chung, I; Eastman, A; Garner, KM; Montano, R; Parry, D | 1 |
| Aft, RL; Cai, S; Ellis, MJ; Goiffon, RJ; Guo, Z; Hoog, J; Li, S; Lin, L; Ma, CX; Piwnica-Worms, H; Prat, A; Ryan, CE; Schaiff, WT | 1 |
| Darwich, Z; Klymchenko, AS; Kucherak, OA; Mély, Y; Richert, L | 1 |
| Bernard, PS; Brenin, CM; Cai, SR; Craig Lockhart, A; Creekmore, AN; Dancey, J; Doyle, LA; Ebbert, M; Ellis, MJ; Fracasso, PM; Guo, Z; Ma, CX; Mwandoro, T; Naughton, MJ; Petroni, GR; Picus, J; Piwnica-Worms, H; Pluard, TJ; Reed, J; Ryan, CE; Watson, M; Yarde, ER | 1 |
| Jonasch, E; Jope, RS; Sun, M; Zhou, T | 1 |
| Boren, J; Brindle, KM; Mahajan, S; Patel, II; Reichelt, S; Schreiner, A; Steuwe, C; Ul-Hasan, M | 1 |
| Choene, MM; Moela, P; Motadi, LR | 1 |
| Biffoni, M; Buccarelli, M; Cappellari, M; De Luca, G; Fanciulli, M; Goeman, F; Melucci, E; Pilozzi, E; Ricci-Vitiani, L; Signore, M | 1 |
| Furuta, K; Hirata, Y; Ito, Y; Kiuchi, K; Nagase, H; Oh-Hashi, K; Sawada, M; Suzuki, H; Yamada, C; Yamamoto, S | 1 |
| Boroda, AV; Kipryushina, YO; Odintsova, NA | 1 |
| Capek, J; Handl, J; Majtnerova, P; Petira, F; Rousar, T | 1 |
1 review(s) available for camptothecin and staurosporine
| Article | Year |
|---|---|
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine | 1998 |
3 trial(s) available for camptothecin and staurosporine
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Staurosporine; Topoisomerase I Inhibitors | 2008 |
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Staurosporine; Young Adult | 2011 |
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Female; Genes, p53; Humans; Irinotecan; Leukocytes, Mononuclear; Middle Aged; Mutation; Ribosomal Protein S6; Staurosporine; Treatment Outcome | 2013 |
75 other study(ies) available for camptothecin and staurosporine
| Article | Year |
|---|---|
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
Topics: Anti-Bacterial Agents; Fungi; Humans; Hydroxybenzoates; Lactones; Molecular Structure; NF-kappa B; Resorcinols; Structure-Activity Relationship; Zearalenone | 2011 |
Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.
Topics: Adenosine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purine Nucleosides; Retinoblastoma Protein; Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Stereoisomerism | 2020 |
Novel 4-(piperazin-1-yl)quinolin-2(1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2021 |
Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Female; Heterocyclic Compounds; Humans; Polycyclic Compounds; Quinazolines; Triple Negative Breast Neoplasms | 2021 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Transient activation of topoisomerase I in leukotriene D4 signal transduction in human cells.
Topics: Alkaloids; Arachidonic Acids; Camptothecin; Cells, Cultured; Dicarboxylic Acids; DNA Damage; DNA Topoisomerases, Type I; Enzyme Activation; Humans; Kinetics; Signal Transduction; SRS-A; Staurosporine | 1990 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers.
Topics: Adenosine; Alkaloids; Apoptosis; Calcimycin; Camptothecin; Dactinomycin; DNA, Neoplasm; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Staurosporine; Teniposide | 1995 |
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
Topics: Alkaloids; Apoptosis; Camptothecin; Cell Cycle; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Leukemia; Protein Kinase C; Signal Transduction; Staurosporine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Brefeldin A; Camptothecin; Cell-Free System; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cyclopentanes; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HL-60 Cells; HT29 Cells; Humans; Mutation; Protein Synthesis Inhibitors; Staurosporine; Time Factors; Tumor Suppressor Protein p53 | 1996 |
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Topics: Alkaloids; Blotting, Western; Camptothecin; Cell Cycle Proteins; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Genes, p53; Humans; Protein Kinase C; S Phase; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Up-Regulation | 1997 |
Apoptosis in the absence of cytochrome c accumulation in the cytosol.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Bleomycin; Blotting, Western; Camptothecin; Cytochrome c Group; Cytosol; Enzyme Inhibitors; Etoposide; Humans; Hydroxamic Acids; Lymphoma; Microscopy, Fluorescence; Mitochondria; Phalloidine; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1998 |
Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell lines.
Topics: Apoptosis; Brain Neoplasms; Caffeine; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; G2 Phase; Humans; Staurosporine; Tumor Cells, Cultured | 1998 |
Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells.
Topics: Animals; Anisomycin; Antibodies; Antibody Specificity; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Cisplatin; Cycloheximide; DNA Fragmentation; Enzyme Activation; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Manganese; Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Ribosomal Protein S6 Kinases; Serine; Staurosporine; Threonine | 1998 |
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Lineage-related susceptibility of human hemopoietic cell lines to apoptosis.
Topics: Apoptosis; Camptothecin; Cell Line; Cold Temperature; DNA Fragmentation; Hematopoiesis; Hematopoietic System; Hot Temperature; Humans; Microscopy, Electron; Ribavirin; Staurosporine | 1999 |
Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture.
Topics: Annexin A5; Apoptosis; Benzopyrans; Camptothecin; Cell Cycle; Cells, Cultured; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; G1 Phase; Gene Expression; Genes, bcl-2; Humans; Hybridomas; Hydrogen-Ion Concentration; Intracellular Fluid; Microscopy, Fluorescence; Naphthols; Proto-Oncogene Proteins c-bcl-2; Rhodamines; Sensitivity and Specificity; Staurosporine | 1998 |
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Topics: Alkaloids; Androstadienes; Antigens, Nuclear; Ataxia Telangiectasia; Camptothecin; Cell Cycle; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Ku Autoantigen; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Staurosporine; Tumor Cells, Cultured; Wortmannin | 1999 |
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Caspase Inhibitors; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Neoplasm Proteins; Nuclear Proteins; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Staurosporine; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates | 1999 |
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; G2 Phase; Humans; S Phase; Staurosporine; Tumor Cells, Cultured | 2000 |
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Butyrates; Camptothecin; Caspase 3; Caspases; Cell Survival; Colonic Neoplasms; Drug Interactions; Ganciclovir; Humans; Membrane Proteins; Paclitaxel; Peptide Hydrolases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Simplexvirus; Staurosporine; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 2000 |
UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; Camptothecin; Cell Cycle; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Neoplasm Proteins; Protein Kinase C; Staurosporine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Angiotensin II does not induce apoptosis but rather prevents apoptosis in cardiomyocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; Camptothecin; Cell Nucleus; Cell Separation; Cells, Cultured; Chick Embryo; Culture Media, Serum-Free; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Heart; In Situ Nick-End Labeling; Mice; Myocardium; Necrosis; Propidium; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors | 2000 |
Chemical-induced apoptotic cell death in tomato cells: involvement of caspase-like proteases.
Topics: Animals; Apoptosis; Camptothecin; Carboxylic Acids; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Fumonisins; In Situ Nick-End Labeling; Mammals; Mycotoxins; Solanum lycopersicum; Staurosporine | 2000 |
Protection of normal proliferating cells against chemotherapy by staurosporine-mediated, selective, and reversible G(1) arrest.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast; Breast Neoplasms; Camptothecin; Cells, Cultured; Cyclin-Dependent Kinases; Cytoprotection; Doxorubicin; Enzyme Inhibitors; Epithelial Cells; Feasibility Studies; Female; Flow Cytometry; Humans; Interphase; Lymphocytes; Precipitin Tests; Staurosporine; Time Factors; Tumor Cells, Cultured | 2000 |
Monochloramine inhibits etoposide-induced apoptosis with an increase in DNA aberration.
Topics: Aneuploidy; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Cycle; Cell Division; Cell Size; Cell Survival; Chloramines; DNA; DNA Damage; Enzyme Activation; Etoposide; Humans; Jurkat Cells; Oxidants; Staurosporine | 2001 |
Vitamin D compounds exert anti-apoptotic effects in human osteosarcoma cells in vitro.
Topics: Apoptosis; Camptothecin; Humans; Osteosarcoma; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vitamin D | 2001 |
UCN-01 dose-dependent inhibition of normal hyperproliferative cells in mice.
Topics: Alkaloids; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bone Marrow; Bone Marrow Cells; Bromodeoxyuridine; Camptothecin; Cell Division; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Protein Kinase C; Staurosporine; Topoisomerase I Inhibitors; Topotecan | 2001 |
Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis.
Topics: Apoptosis; Camptothecin; Cell Membrane Permeability; Colon; Diuretics, Osmotic; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Gastrointestinal Agents; Histones; HT29 Cells; Humans; Indoles; Intestinal Mucosa; L-Lactate Dehydrogenase; Lactulose; Mannitol; Poly(ADP-ribose) Polymerases; Polyethylene Glycols; Solvents; Staining and Labeling; Staurosporine; Tritium | 2001 |
Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the alpha B-crystallin gene.
Topics: Animals; Apoptosis; Blotting, Northern; Blotting, Western; Camptothecin; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Crystallins; DNA; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Gene Expression Regulation; Genes, bcl-2; Genes, Reporter; Humans; Lens, Crystalline; Mice; Oxidative Stress; Precipitin Tests; Protein Binding; Proto-Oncogene Mas; Rabbits; RNA; Staurosporine; Time Factors; Transfection; Water | 2001 |
Detection of caspase activation in situ by fluorochrome-labeled caspase inhibitors.
Topics: Affinity Labels; Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase Inhibitors; Caspases; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluoresceins; Fluorescent Dyes; HeLa Cells; Humans; Jurkat Cells; Microscopy, Fluorescence; Staurosporine | 2001 |
Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.
Topics: Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Caspase Inhibitors; Caspases; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Etoposide; GADD45 Proteins; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Macromolecular Substances; Membrane Glycoproteins; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Isoforms; Proteins; Recombinant Fusion Proteins; rho GTP-Binding Proteins; Sequence Alignment; Signal Transduction; Staurosporine; TATA-Binding Protein Associated Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor TFIID; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Camptothecin; Cell Survival; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Immunohistochemistry; Indicators and Reagents; Luminescent Proteins; Nerve Degeneration; Neurons; Neurotoxins; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Simplexvirus; Staurosporine; Transcription Factor Brn-3; Transcription Factors | 2001 |
Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?
Topics: Active Transport, Cell Nucleus; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Cell Nucleus; Cisplatin; Culture Media, Serum-Free; DNA Fragmentation; Etoposide; HeLa Cells; Humans; Membrane Potentials; Mitochondria; Neoplasm Proteins; Phosphatidylserines; Signal Transduction; Staurosporine; Time Factors; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
An MCL1-overexpressing Burkitt lymphoma subline exhibits enhanced survival on exposure to serum deprivation, topoisomerase inhibitors, or staurosporine but remains sensitive to 1-beta-D-arabinofuranosylcytosine.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Burkitt Lymphoma; Camptothecin; Cell Survival; Culture Media, Serum-Free; Cytarabine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Topoisomerase Inhibitors; Tumor Cells, Cultured | 2002 |
Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
Topics: Alkaloids; Breast; Camptothecin; cdc25 Phosphatases; Cell Cycle Proteins; Cell Death; Cells, Cultured; Cyclin A; Cyclin B; DNA Damage; Enzyme Inhibitors; Female; G1 Phase; Genes, cdc; Humans; Irinotecan; Kinetics; Mitosis; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53 | 2002 |
Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease.
Topics: Apoptosis; Camptothecin; Cell Size; Etoposide; HeLa Cells; Humans; Jurkat Cells; Macrophages; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; S-Nitrosoglutathione; Staurosporine | 2002 |
Silkworm hemolymph as a potent inhibitor of apoptosis in Sf9 cells.
Topics: Animals; Apoptosis; Bombyx; Camptothecin; Caspase 1; Caspases; Cell Line; Dactinomycin; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Hemolymph; Insecta; Mass Spectrometry; Protein Synthesis Inhibitors; Staurosporine; Time Factors | 2002 |
Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma; Cell Cycle; Colonic Neoplasms; Etoposide; Humans; Staurosporine; Topoisomerase Inhibitors; Tumor Suppressor Protein p53 | 2002 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Camptothecin; Cell Line; Glioblastoma; Humans; Irinotecan; Naphthalenes; Perylene; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 2003 |
Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Camptothecin; Carrier Proteins; Cell Count; Cell Death; Cell Survival; Cells, Cultured; DNA-Binding Proteins; DNA, Antisense; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Ganglia, Sensory; Heterozygote; Humans; Immunohistochemistry; In Vitro Techniques; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Knockout; Nerve Growth Factor; Neurons, Afferent; Protein-Tyrosine Kinases; Receptor, trkA; Receptor, trkC; Sciatic Neuropathy; Staurosporine; Time Factors; Transcription Factor Brn-3A; Transcription Factors | 2003 |
Herpes simplex virus UL14 protein blocks apoptosis.
Topics: Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Epithelial Cells; Etoposide; Herpesvirus 2, Human; Humans; Osmotic Pressure; Poly(ADP-ribose) Polymerases; Staurosporine; Viral Proteins | 2003 |
Nucleolus in apoptosis-induced mouse preimplantation embryos.
Topics: Animals; Apoptosis; Biomarkers; Blastocyst; Blastomeres; Camptothecin; Cell Nucleolus; Cell Survival; Chromosomal Proteins, Non-Histone; Dactinomycin; Female; Fluorescent Antibody Technique, Indirect; Mice; Mice, Inbred ICR; Nuclear Proteins; Nucleophosmin; Phosphoproteins; Pregnancy; Staurosporine | 2003 |
Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Chlorophyll; Drug Resistance, Neoplasm; Humans; Irinotecan; Neoplasm Proteins; Quinolines; Staurosporine; Topotecan | 2004 |
Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Replication; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; G2 Phase; HCT116 Cells; Humans; Irinotecan; Microscopy, Fluorescence; Mitosis; S Phase; Staurosporine; Topoisomerase I Inhibitors; Transfection; Tumor Suppressor Protein p53 | 2004 |
Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death.
Topics: Animals; Apoptosis; Camptothecin; Caspase 3; Caspase 9; Caspases; Cell Death; Cell Survival; Cells, Cultured; Enzyme Activation; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitric Oxide Donors; Pregnancy; Staurosporine | 2005 |
Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
Topics: Camptothecin; cdc25 Phosphatases; Cell Line, Tumor; Cyclin B; DNA Damage; Female; G2 Phase; Humans; Irinotecan; Repressor Proteins; S Phase; Staurosporine; Transcriptional Activation; Tumor Suppressor Protein p53 | 2005 |
Cell type-specific resistance of trigeminal ganglion neurons towards apoptotic stimuli.
Topics: Animals; Apoptosis; Camptothecin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Herpesvirus 1, Suid; Neurons; Protein Kinases; Pseudorabies; Staurosporine; Swine; Trigeminal Ganglion; Virus Latency | 2006 |
Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis.
Topics: Apoptosis; Bromodeoxyuridine; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Humans; Interphase; Nitriles; Ploidies; Staurosporine; Sulfones | 2006 |
The extracellular release of HMGB1 during apoptotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; HMGB1 Protein; Humans; Hydroxamic Acids; Protein Synthesis Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha | 2006 |
The differential staurosporine-mediated G1 arrest in normal versus tumor cells is dependent on the retinoblastoma protein.
Topics: Animals; Breast; Camptothecin; Cell Line, Transformed; Cyclin-Dependent Kinase 4; Doxorubicin; Drug Resistance; Enzyme Induction; Epithelial Cells; Female; Fibroblasts; G1 Phase; Genes, p53; Genes, Retinoblastoma; Humans; Mice; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Retinoblastoma Protein; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53 | 2006 |
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.
Topics: Camptothecin; DNA; DNA Damage; DNA Replication; Histones; HT29 Cells; Humans; Models, Biological; Protein Transport; Replication Origin; S Phase; Staurosporine | 2007 |
Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
Topics: Camptothecin; Cell Cycle; Cell Proliferation; Checkpoint Kinase 1; Cyclin B; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; G2 Phase; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Irinotecan; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; S Phase; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2008 |
Human RIF1 encodes an anti-apoptotic factor required for DNA repair.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Camptothecin; Carcinoma, Ductal, Breast; Cell Differentiation; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; Enzyme Inhibitors; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2009 |
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage.
Topics: Adenosine Triphosphate; Animals; Camptothecin; cdc25 Phosphatases; Cell Cycle; Cell Death; Cell Line, Transformed; Cerebral Cortex; Chromatin Immunoprecipitation; DNA Damage; Embryo, Mammalian; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Mice; Mice, Knockout; Neurons; NF-kappa B; Proto-Oncogene Proteins c-pim-1; RNA, Messenger; RNA, Small Interfering; Staurosporine; Sulfur Isotopes; Time Factors; Transfection; Up-Regulation | 2010 |
Role for ionic fluxes on cell death and apoptotic volume decrease in cultured cerebellar granule neurons.
Topics: Animals; Apoptosis; Camptothecin; Caspase 3; Cations, Monovalent; Cell Size; Cell Survival; Cells, Cultured; Cerebellum; Cesium; Chloride Channels; Chlorides; Enzyme Activation; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Staurosporine; Tetraethylammonium | 2010 |
Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.
Topics: Animals; Annexin A5; Apoptosis; beta Catenin; Camptothecin; Caspase 3; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; Hippocampus; Humans; Maytansine; Mice; Mice, Transgenic; Mutation; Neuroblastoma; RNA, Small Interfering; Staurosporine; Subcellular Fractions; tau Proteins; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2010 |
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins | 2011 |
Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Death; Cells, Cultured; Cytokines; Enzyme Inhibitors; Inflammation; Insulin; Insulin-Secreting Cells; Insulinoma; Interferon-gamma; Interleukin-1beta; Metabolomics; NF-kappa B; Pancreatic Neoplasms; Rats; Signal Transduction; Staurosporine; Tandem Mass Spectrometry | 2011 |
Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.
Topics: Antimetabolites; Antineoplastic Agents; Blotting, Western; Camptothecin; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Cytarabine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA Damage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Flow Cytometry; Gemcitabine; Humans; Hydroxyurea; Irinotecan; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Pyrimidines; Staurosporine | 2012 |
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; DNA Damage; DNA, Neoplasm; Female; Genes, cdc; Genes, erbB-2; Genes, p53; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Receptors, Estrogen; Receptors, Progesterone; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
Detection of apoptosis through the lipid order of the outer plasma membrane leaflet.
Topics: Apoptosis; Camptothecin; Cell Line, Tumor; Cell Membrane; Cholesterol; Dactinomycin; Fluorescent Dyes; HeLa Cells; Humans; Lipid Bilayers; Lipids; Microscopy, Fluorescence; Oxazines; Spectrometry, Fluorescence; Sphingomyelins; Staurosporine | 2012 |
DDX3 regulates DNA damage-induced apoptosis and p53 stabilization.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Caspases; DEAD-box RNA Helicases; DNA Damage; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunoprecipitation; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2013 |
CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.
Topics: Algorithms; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Screening Assays, Antitumor; Etoposide; Fluorescent Dyes; HCT116 Cells; Humans; Lipid Droplets; Lipids; Microscopy, Fluorescence; Neoplasms; Spectrum Analysis, Raman; Staurosporine | 2014 |
Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Carrier Proteins; Cell Growth Processes; Combined Modality Therapy; DNA-Binding Proteins; Down-Regulation; Female; Gene Silencing; Humans; MCF-7 Cells; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2014 |
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; DNA Damage; Drug Synergism; HCT116 Cells; Humans; Irinotecan; Mice; Neoplastic Stem Cells; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Xenograft Model Antitumor Assays | 2016 |
Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Calcium; Camptothecin; Cell Death; Cell Line; Etoposide; Hippocampus; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Oxindoles; Reactive Oxygen Species; Staurosporine; Tunicamycin | 2018 |
Chemical modulation of apoptosis in molluscan cell cultures.
Topics: Animals; Apoptosis; Camptothecin; Cell Survival; Cells, Cultured; Cold-Shock Response; Humans; Mice; Mitomycin; Mytilus; Staurosporine | 2019 |
Quantitative spectrofluorometric assay detecting nuclear condensation and fragmentation in intact cells.
Topics: Antineoplastic Agents; Apoptosis; Bisbenzimidazole; Camptothecin; Cell Death; Cell Line; Cell Nucleus; Cisplatin; DNA Fragmentation; Flow Cytometry; Hep G2 Cells; Humans; Microscopy, Fluorescence; Reproducibility of Results; Spectrometry, Fluorescence; Staurosporine | 2021 |