Page last updated: 2024-08-22

camptothecin and st 1968

camptothecin has been researched along with st 1968 in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (30.77)29.6817
2010's9 (69.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beretta, G; Biasotti, B; Carenini, N; Carminati, P; Dallavalle, S; De Cesare, M; Ferrari, A; Gallo, G; Martinelli, R; Marzi, M; Merlini, L; Penco, S; Perego, P; Pisano, C; Pratesi, G; Tinti, MO; Zunino, F1
Benedetti, V; Beretta, GL; Carminati, P; Dallavalle, S; De Cesare, M; Merlini, L; Penco, S; Pisano, C; Pratesi, G; Tinelli, S; Zunino, F1
Aulicino, C; Benedetti, V; Bucci, F; Carminati, P; De Cesare, M; Foderà, R; Penco, S; Pisano, C; Vesci, L; Zuco, V; Zunino, F1
Beretta, GL; Carminati, P; Dallavalle, S; De Cesare, M; Ferrara, FF; Foderà, R; Guglielmi, MB; Merlini, L; Morini, G; Orlandi, A; Penco, S; Pisano, C; Pratesi, G; Vesci, L; Zuco, V; Zunino, F1
Bucci, F; Cincinelli, R; Croce, AC; Favini, E; Pisano, C; Supino, R; Tortoreto, M; Zuco, V; Zunino, F1
Benedetti, V; Zuco, V; Zunino, F1
Bucci, F; Castorina, M; Dal Pozzo, A; Esposito, E; Muzi, L; Ni, M; Penco, S; Pisano, C; Vesci, L1
Bucci, F; Cassinelli, G; Cominetti, D; De Cesare, M; Di Francesco, AM; Lanzi, C; Meco, D; Orlandi, A; Passeri, D; Petrangolini, G; Pisano, C; Riccardi, R; Tortoreto, M; Zaffaroni, N; Zuco, V; Zunino, F1
Beretta, GL; De Cesare, M; Perego, P; Zaffaroni, N; Zuco, V1
Bucci, F; Cusano, G; Di Francesco, AM; Meco, D; Patriarca, V; Pierri, F; Pisano, C; Riccardi, R; Torella, AR1
Cominetti, D; De Cesare, M; Lauricella, C; Pisano, C; Veronese, SM; Zaffaroni, N; Zuco, V; Zunino, F1
Barbieri, P; Cresta, S; Delmonte, A; Fasolo, A; Gallerani, E; Gianni, L; Hess, D; Joerger, M; Pace, S; Sessa, C1
Barbieri, P; Delmonte, A; Gallerani, E; Hess, D; Joerger, M; Pace, S; Sessa, C1

Reviews

1 review(s) available for camptothecin and st 1968

ArticleYear
Namitecan: a hydrophilic camptothecin with a promising preclinical profile.
    Current medicinal chemistry, 2012, Volume: 19, Issue:21

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Models, Molecular; Structure-Activity Relationship

2012

Trials

2 trial(s) available for camptothecin and st 1968

ArticleYear
Integrative population pharmacokinetic and pharmacodynamic dose finding approach of the new camptothecin compound namitecan (ST1968).
    British journal of clinical pharmacology, 2015, Volume: 80, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Blood Platelets; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Male; Middle Aged; Neutrophils; Topoisomerase I Inhibitors

2015
Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors.
    Investigational new drugs, 2015, Volume: 33, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms

2015

Other Studies

10 other study(ies) available for camptothecin and st 1968

ArticleYear
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity.
    Journal of medicinal chemistry, 2001, Sep-27, Volume: 44, Issue:20

    Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Imines; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Nude; Quantitative Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured

2001
Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series.
    Biochemical pharmacology, 2007, Mar-01, Volume: 73, Issue:5

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA Cleavage; DNA Topoisomerases, Type I; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental

2007
Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.
    European journal of cancer (Oxford, England : 1990), 2008, Volume: 44, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carcinoma, Squamous Cell; Caspase 3; DNA Damage; Drug Evaluation; Female; Humans; Irinotecan; Male; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured

2008
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:7

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Female; Humans; Mice; Mice, Nude; Microbial Viability; Mutant Proteins; Saccharomyces cerevisiae; Topotecan; Xenograft Model Antitumor Assays

2008
Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma.
    Biochemical pharmacology, 2010, Feb-15, Volume: 79, Issue:4

    Topics: Animals; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Nude; Topotecan; Xenograft Model Antitumor Assays

2010
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.
    Cancer letters, 2010, Jun-28, Volume: 292, Issue:2

    Topics: Ataxia Telangiectasia Mutated Proteins; Camptothecin; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA-Binding Proteins; Female; Humans; Infrared Rays; Ovarian Neoplasms; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins; Ultraviolet Rays

2010
Conjugates of a novel 7-substituted camptothecin with RGD-peptides as α(v)β₃ integrin ligands: An approach to tumor-targeted therapy.
    Bioconjugate chemistry, 2010, Nov-17, Volume: 21, Issue:11

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Integrin alphaVbeta3; Ligands; Mice; Molecular Conformation; Oligopeptides; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2010
The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.
    Biochemical pharmacology, 2012, Jul-15, Volume: 84, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Chemokine CCL2; Chemokine CXCL16; Chemokines, CXC; DNA Topoisomerases, Type I; Female; Fibroblast Growth Factor 2; Humans; Indoles; Mice; Mice, Nude; Pyrroles; Receptors, Scavenger; Rhabdomyosarcoma; Sarcoma; Sunitinib; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2012
Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Line, Tumor; Cerebellar Neoplasms; Child; Comet Assay; DNA Damage; Drug Synergism; Humans; Irinotecan; Medulloblastoma; Mice; Mice, Nude; Neuroblastoma; Neuroectodermal Tumors, Primitive; Platinum Compounds; Xenograft Model Antitumor Assays

2012
Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Feb-15, Volume: 20, Issue:4

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; DNA Copy Number Variations; Drug Synergism; ErbB Receptors; Gene Dosage; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Xenograft Model Antitumor Assays

2014