Page last updated: 2024-08-22

camptothecin and serine

camptothecin has been researched along with serine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's3 (12.50)18.2507
2000's13 (54.17)29.6817
2010's7 (29.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Han, CS; Huang, CC; Shen, CM; Wang, SW; Wu, FG; Xu, B; Yue, XF1
Beitrand, R; Jenkins, J; Kohlhagen, G; Pommier, Y; Tabuchi, A; Tanizawa, A1
Adachi, K; Hirata, Y; Kiuchi, K1
Bailly, C; Carrasco, C; Hamy, F; Prudhomme, M; Rubin, E; Saleem, A; Vezin, H1
Bargonetti, J; Chicas, A; Kramer, FR; Olivier, M; Taya, Y; Tyagi, S; Xiao, G1
Ashcroft, M; Taya, Y; Vousden, KH1
Habraken, Y; Piette, J; Piret, B1
Bargonetti, J; Gopen, T; Houser, S; Koshlatyi, S; Lu, T1
Frank, C; Hapke, G; Rustum, YM; Wu, J; Yin, MB1
Bonner, WM; Lowndes, NF; Orr, AH; Pilch, DR; Redon, C; Rogakou, EP1
Morton, CL; Nguyen, NK; Potter, PM; Redinbo, MR; Wierdl, M1
Fanning, E; Gu, J; Liu, H; Podust, VN; Reynolds, AB; Xia, X; Yan, P1
Erster, S; Moll, UM; Nemajerova, A1
Beurel, E; Blivet-Van Eggelpoël, MJ; Cadoret, A; Capeau, J; Desbois-Mouthon, C; Kornprobst, M1
Arakawa, Y; Saito, S; Suzuki, H; Yamada, H1
Bandyopadhyay, K; Banères, JL; Gjerset, RA; Haghighi, A; Lee, C; Parello, J1
Dai, NT; Galvez-Peralta, M; Hackbarth, JS; Karnitz, LM; Kaufmann, SH; Loegering, DA; Meng, XW; Peterson, KL1
Bandyopadhyay, K; Gjerset, RA; Li, P1
Gjerset, RA; Zhao, M1
Castrogiovanni, C; De Backer, O; Dumont, P; Vandaudenard, M; Waterschoot, B1
Ikura, M; Ikura, T; Matsuda, S; Matsuda, T; Matsuda, Y; Yanagisawa, SY1
Bernas, T; Berniak, K; Bujnowicz, L; Darzynkiewicz, Z; Dobrucki, J; Hoang, A; Rybak, P; Zarębski, M1
Castrogiovanni, C; De Backer, O; Dumont, P; Waterschoot, B1
Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Zajkowicz, A; Łasut, B1

Other Studies

24 other study(ies) available for camptothecin and serine

ArticleYear
Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:4

    Topics: Alkaloids; Amaryllidaceae Alkaloids; Amino Acids, Dicarboxylic; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Cell Line; China; Cricetinae; Cricetulus; Crossing Over, Genetic; Harringtonines; Homoharringtonine; Humans; Indolizines; Lung; Lymphoid Tissue; Mutagenicity Tests; Serine; Sister Chromatid Exchange

1983
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
    The Journal of biological chemistry, 1993, Dec-05, Volume: 268, Issue:34

    Topics: Amino Acid Sequence; Animals; Arabidopsis; Base Sequence; Camptothecin; Cell Line; Cloning, Molecular; Conserved Sequence; Cricetinae; Cricetulus; DNA Primers; DNA Topoisomerases, Type I; DNA, Complementary; Drosophila melanogaster; Drug Resistance; Glycine; Humans; Lung; Mice; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine; Viruses

1993
Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells.
    Neuroreport, 1998, Sep-14, Volume: 9, Issue:13

    Topics: Animals; Anisomycin; Antibodies; Antibody Specificity; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Cisplatin; Cycloheximide; DNA Fragmentation; Enzyme Activation; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Manganese; Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Ribosomal Protein S6 Kinases; Serine; Staurosporine; Threonine

1998
The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles.
    Biochemistry, 1999, Jul-06, Volume: 38, Issue:27

    Topics: Amino Acid Substitution; Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Camptothecin; Carbazoles; DNA Damage; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glucosides; Humans; Indoles; Intercalating Agents; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Serine; Topoisomerase I Inhibitors

1999
A DNA damage signal is required for p53 to activate gadd45.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Acetylation; Androstadienes; Camptothecin; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deoxyribonuclease I; DNA; DNA Damage; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Wortmannin

2000
Stress signals utilize multiple pathways to stabilize p53.
    Molecular and cellular biology, 2000, Volume: 20, Issue:9

    Topics: Blotting, Northern; Camptothecin; Cells, Cultured; Chelating Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Deferoxamine; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Humans; Immunoblotting; Microscopy, Fluorescence; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Stress, Physiological; Time Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
S phase dependence and involvement of NF-kappaB activating kinase to NF-kappaB activation by camptothecin.
    Biochemical pharmacology, 2001, Sep-01, Volume: 62, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Activation; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; NF-kappaB-Inducing Kinase; Peptide Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; S Phase; Serine; Signal Transduction; Time Factors; Transfection

2001
Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.
    Biochemical and biophysical research communications, 2001, Dec-21, Volume: 289, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Bleomycin; Camptothecin; Cell Cycle; DNA Damage; DNA, Neoplasm; Drug Stability; Humans; Leukemia, Myeloid; Phosphorylation; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001
Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38.
    International journal of oncology, 2002, Volume: 21, Issue:5

    Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Phytogenic; Camptothecin; Carrier Proteins; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; DNA Damage; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; G2 Phase; Head and Neck Neoplasms; Humans; Irinotecan; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Serine; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase

2002
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.
    EMBO reports, 2003, Volume: 4, Issue:7

    Topics: Animals; Camptothecin; Cell Cycle; Chromosomes, Fungal; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Electrophoresis, Gel, Pulsed-Field; Histones; Humans; Mutation, Missense; Saccharomyces cerevisiae; Serine; Topoisomerase I Inhibitors

2003
Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.
    Biochemistry, 2004, Feb-24, Volume: 43, Issue:7

    Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Camptothecin; Carboxylic Ester Hydrolases; Catalysis; Computer Simulation; COS Cells; DNA Mutational Analysis; Humans; Irinotecan; Kinetics; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Rabbits; Serine; Viscosity

2004
Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci.
    Molecular biology of the cell, 2004, Volume: 15, Issue:7

    Topics: Amino Acid Motifs; Amino Acid Sequence; Camptothecin; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; DNA; DNA Damage; DNA Helicases; DNA Mutational Analysis; G1 Phase; Humans; Intracellular Space; Mitomycin; Molecular Sequence Data; Phosphorylation; Serine

2004
The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria.
    Cell death and differentiation, 2005, Volume: 12, Issue:2

    Topics: Acetylation; Camptothecin; Cell Line, Tumor; Cell Nucleus; DNA Damage; HCT116 Cells; Humans; Lysine; Mitochondria; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Serine; Tumor Suppressor Protein p53

2005
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Chromones; Cytochromes c; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Serine; Transfection; Tumor Suppressor Protein p53

2005
Novel missense mutation of the DNA topoisomerase I gene in SN-38-resistant DLD-1 cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:3

    Topics: Amino Acid Substitution; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Glycine; Humans; Irinotecan; Mutation, Missense; Protein Conformation; Serine

2006
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
    Biochemistry, 2007, Dec-11, Volume: 46, Issue:49

    Topics: Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type I; Gene Expression Regulation; Humans; Lung Neoplasms; Phosphorylation; Phosphoserine; Serine; Tumor Suppressor Protein p14ARF

2007
Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I.
    The Journal of biological chemistry, 2008, Jun-13, Volume: 283, Issue:24

    Topics: Amino Acid Sequence; Camptothecin; CDC2 Protein Kinase; DNA; DNA Topoisomerases, Type I; Gene Expression Regulation, Enzymologic; Humans; K562 Cells; Mitosis; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Sequence Homology, Amino Acid; Serine

2008
CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Casein Kinase II; Cell Line, Tumor; DNA Fragmentation; DNA Topoisomerases, Type I; DNA, Superhelical; Drug Resistance, Neoplasm; Epitopes; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Plasmids; Serine; Topoisomerase I Inhibitors

2012
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Gene Expression; Humans; Irinotecan; Lung; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Phosphorylation; Serine; Topotecan

2015
Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20.
    Cancer biology & therapy, 2015, Volume: 16, Issue:9

    Topics: Antibiotics, Antineoplastic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Camptothecin; Caspases; Doxorubicin; HCT116 Cells; Humans; Mitochondrial Proteins; Peptide Fragments; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Protein Stability; Protein Transport; Proteolysis; Serine; Tumor Suppressor Protein p53

2015
Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 151, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Aminacrine; Camptothecin; Cell Cycle Proteins; Chromosome Aberrations; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; MCF-7 Cells; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nuclear Proteins; Phosphorylation; Propyl Gallate; Recombinant Fusion Proteins; Serine; Trans-Activators; Transfection

2016
Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.
    Oncotarget, 2016, Aug-02, Volume: 7, Issue:31

    Topics: A549 Cells; Camptothecin; DNA Breaks, Double-Stranded; DNA Damage; Etoposide; Histones; Humans; Microscopy, Confocal; Mitoxantrone; Phosphorylation; Serine; Tumor Suppressor p53-Binding Protein 1

2016
Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.
    Cell death and differentiation, 2018, Volume: 25, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; CRISPR-Cas Systems; Humans; Mitochondria; Mutation; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Serine; Transcription, Genetic; Tumor Suppressor Protein p53

2018
PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
    Archives of biochemistry and biophysics, 2018, 10-01, Volume: 655

    Topics: Amino Acid Sequence; Apoptosis; bcl-Associated Death Protein; Camptothecin; Cell Line, Tumor; Dactinomycin; Drug Synergism; Gene Knockdown Techniques; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; RNA, Messenger; Serine; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53; Up-Regulation

2018