camptothecin has been researched along with serine in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 13 (54.17) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, CS; Huang, CC; Shen, CM; Wang, SW; Wu, FG; Xu, B; Yue, XF | 1 |
| Beitrand, R; Jenkins, J; Kohlhagen, G; Pommier, Y; Tabuchi, A; Tanizawa, A | 1 |
| Adachi, K; Hirata, Y; Kiuchi, K | 1 |
| Bailly, C; Carrasco, C; Hamy, F; Prudhomme, M; Rubin, E; Saleem, A; Vezin, H | 1 |
| Bargonetti, J; Chicas, A; Kramer, FR; Olivier, M; Taya, Y; Tyagi, S; Xiao, G | 1 |
| Ashcroft, M; Taya, Y; Vousden, KH | 1 |
| Habraken, Y; Piette, J; Piret, B | 1 |
| Bargonetti, J; Gopen, T; Houser, S; Koshlatyi, S; Lu, T | 1 |
| Frank, C; Hapke, G; Rustum, YM; Wu, J; Yin, MB | 1 |
| Bonner, WM; Lowndes, NF; Orr, AH; Pilch, DR; Redon, C; Rogakou, EP | 1 |
| Morton, CL; Nguyen, NK; Potter, PM; Redinbo, MR; Wierdl, M | 1 |
| Fanning, E; Gu, J; Liu, H; Podust, VN; Reynolds, AB; Xia, X; Yan, P | 1 |
| Erster, S; Moll, UM; Nemajerova, A | 1 |
| Beurel, E; Blivet-Van Eggelpoël, MJ; Cadoret, A; Capeau, J; Desbois-Mouthon, C; Kornprobst, M | 1 |
| Arakawa, Y; Saito, S; Suzuki, H; Yamada, H | 1 |
| Bandyopadhyay, K; Banères, JL; Gjerset, RA; Haghighi, A; Lee, C; Parello, J | 1 |
| Dai, NT; Galvez-Peralta, M; Hackbarth, JS; Karnitz, LM; Kaufmann, SH; Loegering, DA; Meng, XW; Peterson, KL | 1 |
| Bandyopadhyay, K; Gjerset, RA; Li, P | 1 |
| Gjerset, RA; Zhao, M | 1 |
| Castrogiovanni, C; De Backer, O; Dumont, P; Vandaudenard, M; Waterschoot, B | 1 |
| Ikura, M; Ikura, T; Matsuda, S; Matsuda, T; Matsuda, Y; Yanagisawa, SY | 1 |
| Bernas, T; Berniak, K; Bujnowicz, L; Darzynkiewicz, Z; Dobrucki, J; Hoang, A; Rybak, P; Zarębski, M | 1 |
| Castrogiovanni, C; De Backer, O; Dumont, P; Waterschoot, B | 1 |
| Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Zajkowicz, A; Łasut, B | 1 |
24 other study(ies) available for camptothecin and serine
| Article | Year |
|---|---|
Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Amino Acids, Dicarboxylic; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; Cell Line; China; Cricetinae; Cricetulus; Crossing Over, Genetic; Harringtonines; Homoharringtonine; Humans; Indolizines; Lung; Lymphoid Tissue; Mutagenicity Tests; Serine; Sister Chromatid Exchange | 1983 |
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
Topics: Amino Acid Sequence; Animals; Arabidopsis; Base Sequence; Camptothecin; Cell Line; Cloning, Molecular; Conserved Sequence; Cricetinae; Cricetulus; DNA Primers; DNA Topoisomerases, Type I; DNA, Complementary; Drosophila melanogaster; Drug Resistance; Glycine; Humans; Lung; Mice; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine; Viruses | 1993 |
Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells.
Topics: Animals; Anisomycin; Antibodies; Antibody Specificity; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Cisplatin; Cycloheximide; DNA Fragmentation; Enzyme Activation; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Manganese; Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Ribosomal Protein S6 Kinases; Serine; Staurosporine; Threonine | 1998 |
The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles.
Topics: Amino Acid Substitution; Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Camptothecin; Carbazoles; DNA Damage; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glucosides; Humans; Indoles; Intercalating Agents; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Serine; Topoisomerase I Inhibitors | 1999 |
A DNA damage signal is required for p53 to activate gadd45.
Topics: Acetylation; Androstadienes; Camptothecin; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deoxyribonuclease I; DNA; DNA Damage; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Wortmannin | 2000 |
Stress signals utilize multiple pathways to stabilize p53.
Topics: Blotting, Northern; Camptothecin; Cells, Cultured; Chelating Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Deferoxamine; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Humans; Immunoblotting; Microscopy, Fluorescence; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Stress, Physiological; Time Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
S phase dependence and involvement of NF-kappaB activating kinase to NF-kappaB activation by camptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Activation; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; NF-kappaB-Inducing Kinase; Peptide Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; S Phase; Serine; Signal Transduction; Time Factors; Transfection | 2001 |
Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Bleomycin; Camptothecin; Cell Cycle; DNA Damage; DNA, Neoplasm; Drug Stability; Humans; Leukemia, Myeloid; Phosphorylation; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Phytogenic; Camptothecin; Carrier Proteins; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; DNA Damage; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; G2 Phase; Head and Neck Neoplasms; Humans; Irinotecan; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Serine; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 2002 |
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.
Topics: Animals; Camptothecin; Cell Cycle; Chromosomes, Fungal; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Electrophoresis, Gel, Pulsed-Field; Histones; Humans; Mutation, Missense; Saccharomyces cerevisiae; Serine; Topoisomerase I Inhibitors | 2003 |
Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.
Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Camptothecin; Carboxylic Ester Hydrolases; Catalysis; Computer Simulation; COS Cells; DNA Mutational Analysis; Humans; Irinotecan; Kinetics; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Rabbits; Serine; Viscosity | 2004 |
Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci.
Topics: Amino Acid Motifs; Amino Acid Sequence; Camptothecin; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; DNA; DNA Damage; DNA Helicases; DNA Mutational Analysis; G1 Phase; Humans; Intracellular Space; Mitomycin; Molecular Sequence Data; Phosphorylation; Serine | 2004 |
The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria.
Topics: Acetylation; Camptothecin; Cell Line, Tumor; Cell Nucleus; DNA Damage; HCT116 Cells; Humans; Lysine; Mitochondria; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Serine; Tumor Suppressor Protein p53 | 2005 |
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Chromones; Cytochromes c; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Serine; Transfection; Tumor Suppressor Protein p53 | 2005 |
Novel missense mutation of the DNA topoisomerase I gene in SN-38-resistant DLD-1 cells.
Topics: Amino Acid Substitution; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Glycine; Humans; Irinotecan; Mutation, Missense; Protein Conformation; Serine | 2006 |
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
Topics: Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type I; Gene Expression Regulation; Humans; Lung Neoplasms; Phosphorylation; Phosphoserine; Serine; Tumor Suppressor Protein p14ARF | 2007 |
Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I.
Topics: Amino Acid Sequence; Camptothecin; CDC2 Protein Kinase; DNA; DNA Topoisomerases, Type I; Gene Expression Regulation, Enzymologic; Humans; K562 Cells; Mitosis; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Sequence Homology, Amino Acid; Serine | 2008 |
CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.
Topics: Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Casein Kinase II; Cell Line, Tumor; DNA Fragmentation; DNA Topoisomerases, Type I; DNA, Superhelical; Drug Resistance, Neoplasm; Epitopes; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Plasmids; Serine; Topoisomerase I Inhibitors | 2012 |
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colonic Neoplasms; DNA Topoisomerases, Type I; Female; Gene Expression; Humans; Irinotecan; Lung; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Phosphorylation; Serine; Topotecan | 2015 |
Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20.
Topics: Antibiotics, Antineoplastic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Camptothecin; Caspases; Doxorubicin; HCT116 Cells; Humans; Mitochondrial Proteins; Peptide Fragments; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Protein Stability; Protein Transport; Proteolysis; Serine; Tumor Suppressor Protein p53 | 2015 |
Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
Topics: Adaptor Proteins, Signal Transducing; Aminacrine; Camptothecin; Cell Cycle Proteins; Chromosome Aberrations; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; MCF-7 Cells; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nuclear Proteins; Phosphorylation; Propyl Gallate; Recombinant Fusion Proteins; Serine; Trans-Activators; Transfection | 2016 |
Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.
Topics: A549 Cells; Camptothecin; DNA Breaks, Double-Stranded; DNA Damage; Etoposide; Histones; Humans; Microscopy, Confocal; Mitoxantrone; Phosphorylation; Serine; Tumor Suppressor p53-Binding Protein 1 | 2016 |
Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; CRISPR-Cas Systems; Humans; Mitochondria; Mutation; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Serine; Transcription, Genetic; Tumor Suppressor Protein p53 | 2018 |
PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Topics: Amino Acid Sequence; Apoptosis; bcl-Associated Death Protein; Camptothecin; Cell Line, Tumor; Dactinomycin; Drug Synergism; Gene Knockdown Techniques; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; RNA, Messenger; Serine; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53; Up-Regulation | 2018 |