Page last updated: 2024-08-22

camptothecin and podophyllotoxin

camptothecin has been researched along with podophyllotoxin in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (11.43)	18.7374
1990's	7 (20.00)	18.2507
2000's	8 (22.86)	29.6817
2010's	13 (37.14)	24.3611
2020's	3 (8.57)	2.80

Authors

Authors	Studies
Fang, X; Shao, L; Wang, S; Zhang, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Balaña-Fouce, R; Carballeira, NM; Cartagena, M; Prada, CF; Reguera, RM; Sanabria, D; Tasdemir, D	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR	1
Borrelli, S; Cappelletti, G; Cartelli, D; Christodoulou, MS; Damia, G; Dosio, F; Ficarra, I; Passarella, D; Ricci, F; Silvani, A; Zucchetti, M	1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR	1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR	1
Liu, Y; Xu, Z; Zhao, SJ	1
Abdelhameid, MK; Ismail, MM; Mohammed, MR; Noha, RM; Salwa, E	1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR	1
Barley, LR; Chang, JY; Cheng, YC; Dethlefsen, LA; Zhou, BS	1
Schaack, J; Schedl, P; Shenk, T	1
Schaak, J; Schedl, P; Shenk, T	1
Chen, AY; Hwang, JL; Juan, CC; Shyy, SH; Whang-Peng, J	1
Bodley, AL; Kupfer, G; Liu, LF	1
Lock, RB; Ross, WE	1
Jacobson-Kram, D; Lim, M; Liu, LF; Williams, JR	1
Sinha, BK	1
Fujii, N; Nakano, H; Saitoh, Y; Yamashita, Y	1
Burris, HA; Muggia, FM	1
Bastow, KF; Cheng, YC; Lee, KH; Wang, HK	1
Bastow, KF; Chang, JY; Chen, HX; Cheng, YC; Fu, Q; Guan, J; Guo, X; Jiang, Z; Lee, KH; Wang, HK; Zhu, XK	1
Dutcher, JP; Marcoullis, G; Novik, Y; O'Boyle, K; Secco, C; Wiernik, PH	1
Gupta, MM; Khanuja, SP; Kumar, JK; Negi, AS; Srivastava, V	1
Hartmann, JT; Lipp, HP	1
Li, X; Xu, W	1
Mou, Y; Shan, T; Zhao, J; Zhou, L	1
Chandra, S	1
Cheng, YC; Gullen, EA; Jiang, ZL; Kim, SW; Lee, KH; Leung, CH; Morris-Natschke, SL; Park, SY; Shi, Q; Ye, D; Zhu, H	1
Cao, YF; Fang, ZZ; Hong, M; Meng, DL; Qi, JQ; Sun, DX; Sun, XY	1
Epifano, F	1
Ding, ZT; Dong, FW; Hu, JM; Jiang, ZH; Kong, QH; Yang, L; Zhou, J; Zi, CT	1

Reviews

9 review(s) available for camptothecin and podophyllotoxin

Article	Year
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. European journal of medicinal chemistry, 2019, Dec-01, Volume: 183 Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triazoles	2019
DNA topoisomerases in cancer therapy. Anti-cancer drug design, 1987, Volume: 2, Issue:2 Topics: Antineoplastic Agents; Camptothecin; DNA Damage; DNA Topoisomerases, Type I; Intercalating Agents; Podophyllotoxin	1987
Topoisomerase inhibitors. A review of their therapeutic potential in cancer. Drugs, 1995, Volume: 49, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Irinotecan; Neoplasms; Podophyllotoxin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan	1995
Clinical development of topoisomerase-interactive drugs. Advances in pharmacology (San Diego, Calif.), 1994, Volume: 29B Topics: Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Neoplasms; Podophyllotoxin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan	1994
20th-century advances in drug therapy in oncology--Part. II. Journal of clinical pharmacology, 2000, Volume: 40, Issue:10 Topics: Antineoplastic Agents; Bridged-Ring Compounds; Camptothecin; Drug Therapy; Humans; Neoplasms; Podophyllotoxin; Taxoids; Topoisomerase I Inhibitors; Vinca Alkaloids	2000
Plant-based anticancer molecules: a chemical and biological profile of some important leads. Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Stilbenes	2005
Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile. Drug safety, 2006, Volume: 29, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Enzyme Inhibitors; Humans; Neoplasms; Podophyllotoxin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2006
Recent patents therapeutic agents for cancer. Recent patents on anti-cancer drug discovery, 2006, Volume: 1, Issue:2 Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Neoplasms; Organoplatinum Compounds; Patents as Topic; Podophyllotoxin; Taxoids	2006
Endophytic fungi: novel sources of anticancer lead molecules. Applied microbiology and biotechnology, 2012, Volume: 95, Issue:1 Topics: Antineoplastic Agents; Camptothecin; Endophytes; Fungi; Paclitaxel; Podophyllotoxin; Symbiosis; Vinca Alkaloids	2012

Other Studies

26 other study(ies) available for camptothecin and podophyllotoxin

Article	Year
CHMIS-C: a comprehensive herbal medicine information system for cancer. Journal of medicinal chemistry, 2005, Mar-10, Volume: 48, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S.); Neoplasms; Phytotherapy; Plant Preparations; United States; United States Food and Drug Administration	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani. Bioorganic & medicinal chemistry letters, 2012, Oct-01, Volume: 22, Issue:19 Topics: Alkynes; Animals; Antiprotozoal Agents; Cell Line; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Leishmania donovani; Macrophages; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Topoisomerase I Inhibitors; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays	2013
New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A. European journal of medicinal chemistry, 2014, Oct-06, Volume: 85 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Carriers; Drug Liberation; Epothilones; Humans; MCF-7 Cells; Microtubules; Nanostructures; Paclitaxel; Podophyllotoxin; Squalene	2014
Highly predictive and interpretable models for PAMPA permeability. Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine	2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity. Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14 Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility	2019
Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells. European journal of medicinal chemistry, 2021, Jan-01, Volume: 209 Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Chromosomal Instability; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Radiation-Sensitizing Agents; Tubulin Modulators	2021
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models. Scientific reports, 2020, 11-26, Volume: 10, Issue:1 Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States	2020
Characterization of camptothecin-resistant Chinese hamster lung cells. Biochemical pharmacology, 1992, Jun-09, Volume: 43, Issue:11 Topics: Animals; Base Sequence; Camptothecin; Cell Line; Cricetinae; Cricetulus; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Resistance; Etoposide; Lung; Molecular Sequence Data; Podophyllotoxin; RNA, Messenger; Vincristine	1992
Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. Journal of virology, 1990, Volume: 64, Issue:1 Topics: Adenovirus Early Proteins; Adenoviruses, Human; Camptothecin; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Viral; HeLa Cells; Humans; Kinetics; Oncogene Proteins, Viral; Podophyllotoxin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	1990
Transcription of adenovirus and HeLa cell genes in the presence of drugs that inhibit topoisomerase I and II function. Nucleic acids research, 1990, Mar-25, Volume: 18, Issue:6 Topics: Adenovirus Early Proteins; Adenoviruses, Human; Antigens, Viral, Tumor; Camptothecin; Exons; Genes; Genes, Viral; Heat-Shock Proteins; HeLa Cells; Humans; Kinetics; Oncogene Proteins, Viral; Podophyllotoxin; RNA, Messenger; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic	1990
Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide. Cancer research, 1989, Feb-15, Volume: 49, Issue:4 Topics: Animals; Antibodies; Base Sequence; Camptothecin; Chromosome Aberrations; Cloning, Molecular; DNA Replication; DNA Topoisomerases, Type II; Escherichia coli; Genes; Genetic Vectors; Humans; Immune Sera; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Podophyllotoxin; Rabbits; Recombinant Proteins; Teniposide; Topoisomerase II Inhibitors	1989
Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targetting antitumor drugs. NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4 Topics: Adenosine Triphosphate; Camptothecin; Cell Survival; Cell Transformation, Neoplastic; Dinitrophenols; HeLa Cells; Humans; Kinetics; Podophyllotoxin; Simian virus 40; Teniposide; Topoisomerase II Inhibitors	1987
Induction of sister chromatid exchanges by inhibitors of topoisomerases. Cell biology and toxicology, 1986, Volume: 2, Issue:4 Topics: Amsacrine; Animals; Camptothecin; Cells, Cultured; Cricetinae; DNA Topoisomerases, Type I; Enzyme Inhibitors; Fibroblasts; Podophyllotoxin; Sister Chromatid Exchange; Teniposide	1986
Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein. The Journal of biological chemistry, 1993, Jun-25, Volume: 268, Issue:18 Topics: Animals; Camptothecin; Catalysis; Cattle; Chromones; Diterpenes; DNA; DNA Topoisomerases, Type I; Hydrolysis; Intercalating Agents; Mitosporic Fungi; Nucleic Acid Conformation; Podophyllotoxin; Topoisomerase I Inhibitors	1993
Antitumor agents--CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents. Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:8 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; DNA; Humans; Podophyllotoxin; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1997
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates. Biochemical pharmacology, 2000, Mar-01, Volume: 59, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Cycle; Disease Models, Animal; DNA; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Tumor Cells, Cultured; Tumor Stem Cell Assay	2000
Plant-derived bioactive compounds produced by endophytic fungi. Mini reviews in medicinal chemistry, 2011, Volume: 11, Issue:2 Topics: Biological Products; Camptothecin; Fungi; Paclitaxel; Plants; Podophyllotoxin; Symbiosis	2011
Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents. Bioorganic & medicinal chemistry, 2012, Jul-15, Volume: 20, Issue:14 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Humans; Podophyllotoxin; Stereoisomerism; Topoisomerase I Inhibitors	2012
Structure-inhibition relationship of podophyllotoxin (PT) analogues towards UDP-glucuronosyltransferase (UGT) isoforms. Die Pharmazie, 2015, Volume: 70, Issue:4 Topics: Binding, Competitive; Camptothecin; Drug Interactions; Enzyme Inhibitors; Estradiol; Glucuronides; Glucuronosyltransferase; Humans; Hymecromone; In Vitro Techniques; Irinotecan; Isoenzymes; Microsomes, Liver; Podophyllotoxin; Structure-Activity Relationship; Substrate Specificity; Trifluoperazine	2015
Novel Anticancer Drugs from Nature. Current medicinal chemistry, 2015, Volume: 22, Issue:30 Topics: Antineoplastic Agents, Phytogenic; Biological Products; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Vinca Alkaloids	2015
Synthesis and antitumor activity of camptothecin- 4β-triazolopodophyllotoxin conjugates. Natural product research, 2020, Volume: 34, Issue:16 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cycloaddition Reaction; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Podophyllotoxin; Structure-Activity Relationship	2020