Compounds > camptothecin
Page last updated: 2024-08-22

camptothecin and olaparib

camptothecin has been researched along with olaparib in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (90.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Chen, C; Chen, J; Chen, S; Dai, Q; Gao, C; Jiang, Y; Yuan, Z1
Akamatsu, Y; Jasin, M1
Bishop, DK; Dejsuphong, D; Hirota, K; Qing, Y; Sakai, W; Takeda, S; Wu, X; Yamamoto, KN; Yamazoe, M1
Kanomata, N; Kozuka, Y; Kurebayashi, J; Moriya, T; Shimo, T; Sonoo, H; Yamashita, T1
Hareyama, M; Matsumoto, H; Matsumoto, Y; Miura, K; Sakata, K; Someya, M; Takahashi, A1
Auerbach, AD; Kim, Y; Lach, FP; Smogorzewska, A; Spitz, GS; Veturi, U1
Fujii, H; Horie, H; Inoue, T; Kotake, K; Miyakura, Y; Sato, F; Sugano, K; Tahara, M; Yasuda, Y1
Doroshow, JH; Ji, J; Morris, J; Murai, J; Pommier, Y; Takeda, S; Zhang, Y1
Bahrami, A; Benavente, C; Bradley, C; Calabrese, C; Caufield, W; Dyer, MA; Freeman, BB; Gordon, B; Goshorn, R; Griffiths, LM; Hatfield, MJ; Karlström, Å; Loh, A; Miller, GM; Pappo, A; Potter, PM; Sablauer, A; Shelat, AA; Shirinifard, A; Snyder, SE; Stewart, E; Thiagarajan, S; Tsurkan, L; Twarog, NR; Wu, J1
Chen, EX; Hagerman, L; Jonker, DJ; Keller, D; McKeever, K; Seymour, L; Siu, LL; Wells, J1
Baldock, RA; Beesley, J; Blair-Reid, S; Daza-Martin, M; Densham, RM; Fletcher, A; Garvin, AJ; Johal, B; Keep, NH; Morris, JR; Neely, R; Pearl, LH; Stone, HR; Strachan, J; Watts, FZ1
Guan, J; Mao, W; Zhao, Q1
Arrojo, R; Cardillo, TM; Goldenberg, DM; Mostafa, AA; Rossi, DL; Sharkey, RM1
Azad, NS; De Jesus-Acosta, A; Donehower, RC; Fine, RL; Goggins, M; Jaffee, EM; Johnson, BA; Laheru, DA; Le, DT; Myzak, MC; Oberstein, PE; Yarchoan, M; Zheng, L1
Gu, S; Jin, L; Ma, J; Ni, X; Pan, Q; Wang, J; Xu, M; Zhen, N; Zhu, J1
Alfano, L; Altieri, A; Bini, L; Caporaso, A; Dell'Aquila, M; Giordano, A; Landi, C; Pentimalli, F1
Gao, X; Ji, J; Li, M; Lv, J; Mao, W; Sun, C; Wang, J; Yang, W; Zhang, L; Zhao, Z1
Batenburg, NL; Coulombe, Y; Masson, JY; Sherker, A; Walker, JR; Zhu, XD1
Cordes, LM; Dorlo, TPC; Figg, WD; Huitema, ADR; Madan, RA; Peer, CJ; Pommier, Y; Schmidt, KT; Sciuto, L; Thomas, A; Wroblewski, S1
Karapetian, M; Kulikova, N; Tsikarishvili, S; Zaalishvili, G1

Trials

2 trial(s) available for camptothecin and olaparib

ArticleYear
A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187.
    Investigational new drugs, 2016, Volume: 34, Issue:4

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Humans; Irinotecan; Male; Middle Aged; Phthalazines; Piperazines; Treatment Outcome

2016
Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2020, Volume: 86, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Camptothecin; Cyclodextrins; Drug Liberation; Female; Half-Life; Humans; Male; Middle Aged; Models, Biological; Neoplasm Staging; Neoplasms; Nitriles; Phenylthiohydantoin; Phthalazines; Piperazines; Topoisomerase I Inhibitors

2020

Other Studies

18 other study(ies) available for camptothecin and olaparib

ArticleYear
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Acridines; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; DNA Topoisomerases; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Structure-Activity Relationship; Topoisomerase Inhibitors; Tumor Cells, Cultured

2017
Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.
    PLoS genetics, 2010, Oct-14, Volume: 6, Issue:10

    Topics: Amino Acid Sequence; Animals; Base Sequence; Camptothecin; Cell Line; Cell Survival; Cells, Cultured; DNA Damage; DNA Repair; Embryo, Mammalian; Embryonic Stem Cells; Female; Fibroblasts; Male; Mice; Mice, Knockout; Molecular Sequence Data; Multiprotein Complexes; Nuclear Proteins; Phthalazines; Piperazines; Protein Binding; Rad51 Recombinase; Recombination, Genetic; Sequence Homology, Amino Acid; Two-Hybrid System Techniques

2010
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
    PLoS genetics, 2011, Volume: 7, Issue:7

    Topics: Animals; BRCA2 Protein; Camptothecin; Cell Line; Cell Proliferation; Chickens; Chromosome Aberrations; Cisplatin; Clone Cells; DNA Damage; Epistasis, Genetic; Gamma Rays; Gene Conversion; Gene Deletion; Genetic Loci; Genome; Homologous Recombination; Models, Biological; Phenotype; Phthalazines; Piperazines; Rad51 Recombinase

2011
Antitumor and anticancer stem cell activity of a poly ADP-ribose polymerase inhibitor olaparib in breast cancer cells.
    Breast cancer (Tokyo, Japan), 2014, Volume: 21, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Irinotecan; Neoplastic Stem Cells; Phosphorylation; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Receptor, ErbB-2

2014
The combination of olaparib and camptothecin for effective radiosensitization.
    Radiation oncology (London, England), 2012, Apr-23, Volume: 7

    Topics: Camptothecin; Cell Line, Tumor; Cell Survival; DNA Breaks, Double-Stranded; DNA Repair; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Phthalazines; Piperazines; Radiation-Sensitizing Agents

2012
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.
    Blood, 2013, Jan-03, Volume: 121, Issue:1

    Topics: Camptothecin; Cell Line; Cross-Linking Reagents; DNA; DNA Mutational Analysis; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Fanconi Anemia; Humans; Mitomycin; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Protein Interaction Mapping; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinases; Topoisomerase I Inhibitors

2013
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:5

    Topics: Animals; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Irinotecan; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerases; Rad51 Recombinase; Tumor Burden; Xenograft Model Antitumor Assays

2014
Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 349, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Survival; Chickens; Dacarbazine; DNA Damage; DNA Repair; Drug Synergism; Enzyme Inhibitors; Humans; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide

2014
Targeting the DNA repair pathway in Ewing sarcoma.
    Cell reports, 2014, Nov-06, Volume: 9, Issue:3

    Topics: Animals; Benzimidazoles; Camptothecin; Cell Death; Cell Line, Tumor; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; Drug Synergism; Enzyme Inhibitors; Irinotecan; Mice, Nude; Molecular Targeted Therapy; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Sarcoma, Ewing; Temozolomide; Xenograft Model Antitumor Assays

2014
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
    Nature structural & molecular biology, 2016, Volume: 23, Issue:7

    Topics: Binding Sites; BRCA1 Protein; Camptothecin; Chromatin; Cloning, Molecular; DNA Breaks, Double-Stranded; DNA Cleavage; DNA Helicases; DNA, Neoplasm; Escherichia coli; Gene Expression; Gene Expression Regulation, Neoplastic; HeLa Cells; Histones; Humans; Models, Molecular; Phthalazines; Piperazines; Protein Binding; Recombinant Proteins; Recombinational DNA Repair; Signal Transduction; Tumor Suppressor p53-Binding Protein 1; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination

2016
Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.
    Biochimica et biophysica acta, 2016, Volume: 1863, Issue:12

    Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Nucleus; Cell Survival; DNA Breaks, Double-Stranded; DNA End-Joining Repair; HEK293 Cells; Humans; Ku Autoantigen; Phthalazines; Piperazines; Plasmids; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Protein Binding; Protein Processing, Post-Translational; PTEN Phosphohydrolase; RNA, Small Interfering; Signal Transduction

2016
Synthetic Lethality Exploitation by an Anti-Trop-2-SN-38 Antibody-Drug Conjugate, IMMU-132, Plus PARP Inhibitors in
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, 07-01, Volume: 23, Issue:13

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Camptothecin; Cell Line, Tumor; DNA Repair; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoconjugates; Indoles; Mice; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Synthetic Lethal Mutations; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2017
Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.
    Oncotarget, 2017, Jul-04, Volume: 8, Issue:27

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Cisplatin; Female; Humans; Irinotecan; Male; Middle Aged; Mitomycin; Neoplasm Staging; Pancreatic Neoplasms; Phthalazines; Piperazines; Retreatment; Treatment Outcome

2017
Ginsenoside Rg1 impairs homologous recombination repair by targeting CtBP-interacting protein and sensitizes hepatoblastoma cells to DNA damage.
    Anti-cancer drugs, 2018, Volume: 29, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carrier Proteins; Cell Growth Processes; Cell Line, Tumor; DNA Damage; Drug Synergism; Endodeoxyribonucleases; Ginsenosides; Hep G2 Cells; Hepatoblastoma; Humans; Hydroxyurea; Liver Neoplasms; Male; Mice; Mice, Nude; Mitomycin; Nuclear Proteins; Phthalazines; Piperazines; Random Allocation; Recombinational DNA Repair; Xenograft Model Antitumor Assays

2018
Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation.
    Nucleic acids research, 2019, 05-07, Volume: 47, Issue:8

    Topics: Antineoplastic Agents; Camptothecin; Checkpoint Kinase 1; Chromatin; DNA; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA, Single-Stranded; Genome, Human; Genomic Instability; HeLa Cells; Heterogeneous Nuclear Ribonucleoprotein D0; Heterogeneous-Nuclear Ribonucleoprotein D; Heterogeneous-Nuclear Ribonucleoprotein U; Histones; Humans; Nucleic Acid Conformation; Nucleic Acid Hybridization; Phosphorylation; Phthalazines; Piperazines; Recombinational DNA Repair; Replication Protein A; Ribonuclease H; RNA Polymerase II; RNA, Small Interfering

2019
Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:10

    Topics: Antineoplastic Agents; Berberine; Breast Neoplasms; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Breaks; DNA Repair; Down-Regulation; Female; Humans; Hydroxyurea; Neoplasm Proteins; Phthalazines; Piperazines; S Phase; X-ray Repair Cross Complementing Protein 1

2019
CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.
    Nucleic acids research, 2019, 11-18, Volume: 47, Issue:20

    Topics: BRCA1 Protein; Camptothecin; Cell Line, Tumor; Cell Survival; Chromatin Assembly and Disassembly; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA Repair Enzymes; Endodeoxyribonucleases; G2 Phase; Humans; Multiprotein Complexes; Phosphorylation; Phosphoserine; Phthalazines; Piperazines; Poly-ADP-Ribose Binding Proteins; Protein Binding; Protein Domains; S Phase; Telomere-Binding Proteins

2019
PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos.
    Biochemical and biophysical research communications, 2021, 04-23, Volume: 550

    Topics: Animals; Apoptosis; Camptothecin; Caspase 3; DNA Topoisomerases, Type I; Drug Synergism; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Topoisomerase I Inhibitors; Zebrafish

2021