Compounds > camptothecin

Page last updated: 2024-08-22

camptothecin and nsc 314622

camptothecin has been researched along with nsc 314622 in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (5.56)	18.2507
2000's	11 (61.11)	29.6817
2010's	6 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cushman, M; Fox, BM; Fukunaga, AK; Jayaraman, M; Kohlhagen, G; Pommier, Y; Strumberg, D; Vroman, JA	1
Antony, S; Cushman, M; Fort, BC; Kohlhagen, G; Meckley, MR; Morrell, A; Nagarajan, M; Pommier, Y	1
Antony, S; Cushman, M; Ioanoviciu, A; Pommier, Y; Staker, BL; Stewart, L	1
Antony, S; Cushman, M; Fox, BM; Hollingshead, M; Ioanoviciu, A; Jayaraman, M; Meckley, MR; Morrell, A; Nagarajan, M; Pommier, Y	1
Agama, K; Antony, S; Cushman, M; Morrell, A; Placzek, MS; Pommier, Y; Steffen, JD	1
Antony, S; Cushman, M; Grella, B; Morrell, A; Parmley, S; Placzek, M; Pommier, Y	1
Antony, S; Cushman, M; Dexheimer, TS; Morrell, A; Parmley, S; Placzek, M; Pommier, Y	1
Cinelli, MA; Cushman, M; Dexheimer, TS; Morrell, A; Pommier, Y; Scher, ES	1
Cinelli, MA; Cordero, B; Cushman, M; Dexheimer, TS; Pommier, Y	1
Cushman, M; Dexheimer, TS; Pommier, Y; Scher, ES; Shao, Z; Song, Y	1
Agama, K; Antony, S; Cinelli, MA; Cushman, M; Dexheimer, TS; Mehta, A; Morrell, AE; Peterson, KE; Pommier, Y	1
Agama, K; Cushman, M; DeGuire, S; Dexheimer, TS; Kiselev, E; Morrell, A; Pommier, Y	1
Agama, K; Cushman, M; Kiselev, E; Pommier, Y	1
Agama, K; Cushman, M; Kiselev, E; Pommier, Y; Sooryakumar, D	1
Agama, K; Cushman, M; Lv, PC; Marchand, C; Pommier, Y	1
Cushman, M; Kohlhagen, G; Nagafuji, P; Paull, KD; Pommier, Y	1
Frøhlich, RF; Grainge, I; Hansen, SG; Jayaram, M; Knudsen, BR; Lisby, M; Westergaard, O	1
Teicher, BA	1

Reviews

1 review(s) available for camptothecin and nsc 314622

Article	Year
Next generation topoisomerase I inhibitors: Rationale and biomarker strategies. Biochemical pharmacology, 2008, Mar-15, Volume: 75, Issue:6 Topics: Animals; Antineoplastic Agents; Biomarkers; Camptothecin; Carbazoles; Humans; Indenes; Indoles; Isoquinolines; Naphthyridines; Topoisomerase I Inhibitors	2008

Other Studies

17 other study(ies) available for camptothecin and nsc 314622

Article	Year
Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors. Journal of medicinal chemistry, 2000, Oct-05, Volume: 43, Issue:20 Topics: Antineoplastic Agents; DNA, Superhelical; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indenes; Isoquinolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2000
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings. Journal of medicinal chemistry, 2004, Nov-04, Volume: 47, Issue:23 Topics: Antineoplastic Agents; Cell Line, Tumor; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Electrophoresis, Polyacrylamide Gel; Humans; Indenes; Isoquinolines; Models, Molecular; Topoisomerase I Inhibitors	2004
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Models, Molecular; Structure-Activity Relationship; Topoisomerase I Inhibitors	2005
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16 Topics: Antineoplastic Agents; Biological Assay; Camptothecin; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Isoquinolines; Models, Chemical; Topoisomerase I Inhibitors	2006
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indenes; Isoquinolines; Lactams; Models, Molecular; Pyridines; Topoisomerase I Inhibitors	2007
Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. Journal of medicinal chemistry, 2007, Sep-06, Volume: 50, Issue:18 Topics: Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; DNA Cleavage; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Indenes; Isoquinolines; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors	2007
Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. Journal of medicinal chemistry, 2007, Sep-06, Volume: 50, Issue:18 Topics: Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; DNA Cleavage; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Indenes; Isoquinolines; Models, Molecular; Molecular Structure; Nitro Compounds; Structure-Activity Relationship; Topoisomerase I Inhibitors	2007
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Drug Design; Humans; Indolizines; Ligands; Models, Molecular; Molecular Structure; Protein Binding; Quinolines; Structure-Activity Relationship; Topoisomerase I Inhibitors	2008
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorganic & medicinal chemistry, 2009, Oct-15, Volume: 17, Issue:20 Topics: Antineoplastic Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Structure-Activity Relationship; Topoisomerase I Inhibitors	2009
Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors. Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Enzyme Inhibitors; Humans; Indenes; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Thermodynamics; Topoisomerase I Inhibitors	2010
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Alcohols; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Hexoses; Humans; Hydrogen Bonding; Indenes; Models, Molecular; Pentoses; Quinolines; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors	2011
7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. Journal of medicinal chemistry, 2011, Sep-08, Volume: 54, Issue:17 Topics: Antineoplastic Agents; Aza Compounds; DNA Cleavage; DNA Topoisomerases, Type I; Humans; Models, Molecular; Molecular Structure; Neoplasms; Quinolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2011
Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships. Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4 Topics: Antineoplastic Agents; Aza Compounds; Cell Line, Tumor; DNA; DNA Cleavage; Drug Screening Assays, Antitumor; Humans; Indenes; Isoquinolines; Models, Molecular; Quantum Theory; Structure-Activity Relationship; Thermodynamics; Topoisomerase I Inhibitors	2012
Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells. Journal of medicinal chemistry, 2014, Feb-27, Volume: 57, Issue:4 Topics: Cell Line, Tumor; Humans; Lactams; Magnetic Resonance Spectroscopy; Quinolines; Spectrometry, Mass, Electrospray Ionization; Topoisomerase I Inhibitors	2014
Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors. Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10 Topics: Drug Design; Humans; Isoquinolines; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship; Topoisomerase I Inhibitors	2014
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison. Molecular pharmacology, 1998, Volume: 54, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Carcinoma; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indenes; Isoquinolines; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1998
Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622. The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10 Topics: Antineoplastic Agents; Binding Sites; Binding, Competitive; Camptothecin; DNA; DNA Damage; DNA Nucleotidyltransferases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evolution, Molecular; Humans; Indenes; Isoquinolines; Kinetics; Models, Biological; Protein Binding; Topoisomerase I Inhibitors	2001