camptothecin has been researched along with nitrophenols in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aburada, M; Hagiwara, H; Kamataki, T; Nagai, E; Narita, M; Yokoi, T | 1 |
| Atsumi, R; Hakusui, H; Hosokawa, M; Nagai, E; Satoh, T; Suzuki, W | 1 |
| Coffman, BL; Green, MD; Iyer, L; King, CD; Ratain, MJ; Roy, SK; Tephly, TR; Whitington, PF | 1 |
| Bugat, R; Canal, P; Chatelut, E; Guichard, S; Hennebelle, I; Terret, C | 1 |
| Band, R; Bowen, D; Cottrell, J; Grem, JL; Guemei, AA; Hehman, H; Ismail, AS; Pavlov, MV; Prudhomme, M; Takimoto, CH; Taylor, RE | 1 |
| Danks, MK; Hyatt, JL; Lee, RE; Morton, CL; Potter, PM; Yoon, KJ | 1 |
| Kim, SR; Kubo, T; Matsumoto, K; Minami, H; Nakajima, T; Ohno, Y; Ohtsu, A; Ozawa, S; Sai, K; Saijo, N; Saito, H; Saito, Y; Sawada, J; Shirao, K; Yamamoto, N; Yoshida, T | 1 |
| Aulds, S; Clarke, S; Crawford, M; Eyers, T; Gallagher, J; Lee, S; Rivory, L; Seale, JP; Solomon, M; Tobin, P | 1 |
| Huang, S; Okumura, K; Sinicrope, FA | 1 |
| Gao, J; Liu, D; Liu, Y; Ren, X; Xu, Y; Zhang, C | 1 |
| Fay, F; Greene, MK; Jarvis, GE; Johnston, PG; Kissenpfennig, A; Longley, DB; Majkut, J; McCloskey, KD; McLaughlin, KM; Schmid, D; Scott, CJ; Small, DM; Spence, S | 1 |
| Cho, SY; Han, JY; Kang, J; Kang, W; Kwon, JY; Lee, A; Lee, C; Min, S; Park, H | 1 |
1 review(s) available for camptothecin and nitrophenols
| Article | Year |
|---|---|
An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts.
Topics: Animals; Antineoplastic Agents; Biomarkers, Pharmacological; Biphenyl Compounds; Camptothecin; Drug Synergism; Graft Survival; Humans; Irinotecan; Mice; Mice, Nude; Mice, SCID; Molecular Targeted Therapy; Nitrophenols; Piperazines; Precision Medicine; Stomach Neoplasms; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
1 trial(s) available for camptothecin and nitrophenols
| Article | Year |
|---|---|
Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan.
Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Butyrylcholinesterase; Butyrylthiocholine; Camptothecin; Carboxylic Ester Hydrolases; Humans; Hydrolysis; Irinotecan; Nitrophenols; Predictive Value of Tests | 2001 |
10 other study(ies) available for camptothecin and nitrophenols
| Article | Year |
|---|---|
Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate.
Topics: Animals; Camptothecin; Drugs, Chinese Herbal; Enzyme Inhibitors; Glucuronates; Glucuronosyltransferase; Irinotecan; Kinetics; Male; Microsomes, Liver; Nitrophenols; Rats; Rats, Wistar | 1995 |
Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Carboxylic Ester Hydrolases; Cattle; Cricetinae; Dogs; Guinea Pigs; Haplorhini; Humans; Hydrolysis; Irinotecan; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Nitrophenols; Organophosphorus Compounds; Rabbits; Rats; Species Specificity | 1994 |
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bilirubin; Camptothecin; Causality; Crigler-Najjar Syndrome; Glucuronosyltransferase; Guanine; Humans; Irinotecan; Isoenzymes; Microsomes, Liver; Nitrophenols; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Uridine Diphosphate; Zidovudine | 1998 |
Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylic Ester Hydrolases; Colon; Colonic Neoplasms; DNA Topoisomerases, Type I; Enzyme Activation; Enzyme Inhibitors; Humans; Irinotecan; Kinetics; Liver; Nitrophenols; Rats; Substrate Specificity; Topoisomerase I Inhibitors | 2000 |
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
Topics: Animals; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Intestinal Mucosa; Irinotecan; Kinetics; Liver; Models, Chemical; Nitrophenols; Protein Biosynthesis; Rabbits; Recombinant Proteins; Transfection | 2004 |
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Topics: Animals; Asian People; Camptothecin; Carboxylesterase; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Humans; Irinotecan; Nitrophenols; Polymorphism, Single Nucleotide; RNA Splicing; Umbelliferones | 2005 |
The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Colorectal Neoplasms; Glucuronidase; Humans; Hydroxyquinolines; Irinotecan; Nitrophenols; Tumor Cells, Cultured | 2006 |
Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.
Topics: Apoptosis; bcl-X Protein; Biphenyl Compounds; Camptothecin; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Humans; Irinotecan; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides | 2008 |
Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.
Topics: Actins; Angiotensin-Converting Enzyme Inhibitors; Animals; Biotransformation; Blotting, Western; Camptothecin; Carboxylic Ester Hydrolases; Constitutive Androstane Receptor; Esters; Hydrolysis; Imidazolidines; Intestines; Irinotecan; Male; Nitrophenols; Organophosphorus Compounds; Parasympathomimetics; Pregnane X Receptor; Prodrugs; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger | 2011 |
Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Drug Compounding; Drug Synergism; Humans; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Nitrophenols; Piperazines; Sulfonamides; Thrombocytopenia | 2014 |