Compounds > camptothecin
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camptothecin and mitoxantrone

camptothecin has been researched along with mitoxantrone in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (16.39)18.2507
2000's34 (55.74)29.6817
2010's17 (27.87)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baguley, BC; Deady, LW; Denny, WA; Rodemann, T; Zhuang, L1
Bu, X; Eleftheriou, A; Hayek, C; Parmar, A; Stewart, BW; Wakelin, LP1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Friedrich, TD; Guzzo, PR; Jason Herr, R; Nacro, K; Peace, D; Zha, CC1
Chan, YL; Chen, HW; Chen, WR; Guh, JH; His, CP; Hsin, LW; Kao, PH; Lee, CH; Lee, O; Li, TK; Wang, HP; Yang, MS1
Austin, CA; Curtis, H; Gilroy, KL; Jobson, A; López-Lázaro, M; Padget, K; Willmore, E1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Addo, SN; Das, SG; Doshi, JM; Hermanson, DL; Srinivasan, B; Tian, D; Xing, C1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sumner, AT1
Darzynkiewicz, Z; Del Bino, G1
Cowan, KH; Horton, JK; Schneider, E; Yang, CJ1
Taguchi, T1
Nakane, S; Suzuki, H1
Ganapathi, R; Grabowski, D1
Tannock, IF; Vukovic, V1
Bhalla, K; Bullock, G; Huang, Y; Maria Ibrado, A; Miyashita, T; Ray, S; Reed, J1
de Jong, LA; Floot, BG; Maliepaard, M; Pluim, D; Ruevekamp-Helmers, MC; Schellens, JH; van Gastelen, MA; van Waardenburg, RC1
Bates, SE; Brangi, M; Ciotti, M; Fojo, T; Kohlhagen, G; Litman, T; Nishiyama, K; Pommier, Y; Robey, R; Takimoto, C1
Cotter, TG; Knox, KA; McGahon, AJ; McKenna, SL; O'Gorman, DM1
Beijnen, JH; Jonker, JW; Maliepaard, M; Scheffer, GL; Schellens, JH; Scheper, RJ; Schinkel, AH; Smit, JW1
Mankouri, HW; Morgan, A1
Beggiolin, G; Carenini, N; Carminati, P; De Cesare, M; De Isabella, P; Palumbo, M; Perego, P; Pezzoni, G; Pisano, C; Pratesi, G; Scheffer, GL; Tartaglia, L; Zunino, F1
Chizuka, A; Iijima, K; Niitsu, N1
Bates, SE; Dean, M; Honjo, Y; Hrycyna, CA; Litman, T; Medina-Pérez, WY; Robey, RW; van de Laar, A; Yan, QW1
Imai, Y; Ishikawa, E; Sugimoto, Y; Tsukahara, S; Tsuruo, T1
Imai, Y; Ishikawa, E; Kage, K; Miki, Y; Nakane, M; Sugimoto, Y; Tsukahara, S; Tsuruo, T1
Fedier, A; Fink, D; Haller, U; Lenherr, L; Schwarz, VA; Steiner, RA1
Doi, S; Kamihira, S; Kawabata, S; Kitazaki, T; Kohno, S; Nakamura, Y; Nakatomi, K; Oka, M; Shiozawa, K; Soda, H; Sugahara, K; Tsurutani, J; Yamada, Y1
Asada, S; Imai, Y; Ishikawa, E; Miwa, M; Sugimoto, Y; Tsukahara, S1
Doi, S; Ikegami, Y; Kitazaki, T; Kohno, S; Mizuta, Y; Murase, K; Nakamura, Y; Nakatomi, K; Oka, M; Ross, DD; Shiozawa, K; Soda, H; Tsurutani, J; Yoshida, H; Yoshikawa, M1
Hirano, T; Iseki, K; Itagaki, S; Itoh, T; Shimamoto, S; Sumi, Y; Takemoto, I1
Doi, S; Ikegami, Y; Itoh, A; Kitazaki, T; Kohno, S; Nakamura, Y; Nakatomi, K; Oka, M; Shiozawa, K; Soda, H; Tsurutani, J; Yoshida, H; Yoshikawa, M1
Adams, DJ; Colvin, OM; Flowers, JL; Rizzieri, DA; Shanks, RH1
Ishikawa, T; Kamachi, T; Nakagawa, H; Okura, I; Saito, H; Tamura, A; Watanabe, M1
Hasegawa, H; Miyagi, T; Nagasaki, A; Nakachi, S; Shinzato, O; Taira, N; Takasu, N; Tomoyose, T1
Bessho, M; Higashihara, M; Kohuri, M; Niitsu, N1
Lee, SH; Sinko, PJ; Su, Y1
Lei, S; Li, XR; Mao, YQ1
Bessho, M; Higashihara, M; Kohori, M; Niitsu, N1
Assaraf, YG; Bram, EE; Grimberg, M; Ifergan, I; Lemke, K; Skladanowski, A1
Allen, WL; Galligan, L; Johnston, PG; Longley, DB; Rogers, KM; Sakai, H; Thomas, M; Wilson, TR1
Abe, T; Goto, J; Hishinuma, T; Kobayashi, M; Mano, N; Okada, M; Takeuchi, T; Unno, M; Yamaguchi, H1
Faissner, R; Gasimova, L; Keese, M; Lewis, A; Löhr, M; Samel, S; Schwenke, K; Shang, E; Yagublu, V1
Alonso, MM; Bhat, KP; Colman, H; Fueyo, J; Gomez-Manzano, C; Gumin, J; Lang, FF; Lee, OH; Liu, D; Martin, V; Pabbisetty, SK; Xu, J1
Azzariti, A; Berardi, F; Colabufo, NA; D'Incalci, M; Paradiso, A; Perrone, R; Porcelli, L; Quatrale, AE; Simone, GM; Xu, JM; Zucchetti, M1
Ma, Y; Wink, M1
Katayama, K; Mitsuhashi, J; Noguchi, K; Shigeta, J; Sugimoto, Y1
Leo, E; Marchand, C; Pommier, Y; Zhang, H1
Dudgeon, DD; Giuliano, KA; Johnston, PA; Lazo, JS; Shinde, SN; Shun, TY; Strock, CJ; Taylor, DL1
Pham, XH; Tran, NQ; Tuteja, N; Tuteja, R1
Darzynkiewicz, Z; Dobrucki, J; Rybak, P; Traganos, F; Zhao, H1
Burckhardt, G; Grottker, J; Hagos, Y; Rosenberger, A1
Albertsson, P; Lennernäs, B; Norrby, K1
Efferth, T; Eichhorn, T; Korn, B; Paulsen, M; Wiench, B1
Boumendjel, A; Di Pietro, A; Falson, P; Freyer, G; Geze, A; Guitton, J; Honorat, M; Payen, L; Sostelly, A; Tod, M; Valdameri, G1
Hirano, S; Kuroda, A; Kuwatani, T; Kyogoku, N; Maki, T; Miyauchi, K; Shichinohe, T; Takeuchi, S; Tsuchikawa, T; Wada, M; Yamamura, Y1
Bernas, T; Berniak, K; Bujnowicz, L; Darzynkiewicz, Z; Dobrucki, J; Hoang, A; Rybak, P; Zarębski, M1
Chen, X; Chen, ZS; Cheng, C; Guo, HQ; Kathawala, RJ; Li, T; Yang, D; Yang, DH1
Ambudkar, SV; Chufan, EE; Fukuda, M; Ishida, M; Iwabuchi, Y; Kanehara, K; Kudoh, K; Murakami, M; Naitoh, T; Ohnuma, S; Shibata, H; Sugisawa, N; Unno, M1
Jiang, S; Lan, S; Ma, D; Mao, D; Shi, K; Yang, X1

Reviews

2 review(s) available for camptothecin and mitoxantrone

ArticleYear
[Recent advance in chemotherapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:16

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Docetaxel; Female; Humans; Irinotecan; Mitoxantrone; Paclitaxel; Randomized Controlled Trials as Topic; Salvage Therapy; Taxoids

1994
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
    Chemistry & biology, 2010, May-28, Volume: 17, Issue:5

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Camptothecin; DNA Topoisomerases; Doxorubicin; Enzyme Inhibitors; Etoposide; Humans; Mitoxantrone; Quinolones; Topoisomerase Inhibitors

2010

Trials

2 trial(s) available for camptothecin and mitoxantrone

ArticleYear
Phase II study of the CPT-11, mitoxantrone and dexamethasone regimen in combination with rituximab in elderly patients with relapsed diffuse large B-cell lymphoma.
    Cancer science, 2006, Volume: 97, Issue:9

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Dexamethasone; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Mitoxantrone; Natriuretic Peptide, Brain; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Prognosis; Recurrence; Rituximab; Survival Analysis; Survival Rate; Treatment Outcome; Troponin T

2006
Phase II study of the irinotecan (CPT-11), mitoxantrone and dexamethasone regimen in elderly patients with relapsed or refractory peripheral T-cell lymphoma.
    Cancer science, 2007, Volume: 98, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dexamethasone; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Lymphoma, T-Cell; Male; Mitoxantrone; Natriuretic Peptides; Neoplasm Recurrence, Local; Stroke Volume; Troponin T; Ventricular Function, Left

2007

Other Studies

57 other study(ies) available for camptothecin and mitoxantrone

ArticleYear
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
    Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Neoplasm Transplantation; Neoplasms, Experimental; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured

2003
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
    Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

    Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA, Superhelical; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; Guanine; Humans; Hydrogen Bonding; Intercalating Agents; Kinetics; Mitosis; Structure-Activity Relationship

2003
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.
    Bioorganic & medicinal chemistry, 2007, Jun-15, Volume: 15, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Pyrroles; Quinones; Spectrometry, Mass, Electrospray Ionization; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2007
Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Amino Acid Sequence; Amino Acids; Anthraquinones; Antineoplastic Agents; Combinatorial Chemistry Techniques; DNA; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2008
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
    Journal of natural products, 2007, Volume: 70, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Curcumin; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Fluorescence; Molecular Structure; Reactive Oxygen Species; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Apoptosis; Benzopyrans; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leukemia; Mitoxantrone; Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
    Journal of cell science, 1992, Volume: 103 ( Pt 1)

    Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Amsacrine; Camptothecin; Cell Line; DNA; Doxorubicin; Humans; In Vitro Techniques; Leukemia, Myeloid; Mitoxantrone; S Phase; Teniposide

1991
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.
    Cancer research, 1995, Sep-15, Volume: 55, Issue:18

    Topics: Antineoplastic Agents; Breast Neoplasms; Camptothecin; Cell Survival; DNA Topoisomerases, Type I; Drug Resistance; Female; Humans; Mitoxantrone; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

1995
Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:2

    Topics: Aclarubicin; Animals; Camptothecin; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Doxorubicin; Etoposide; Fibroblasts; Lung; Mitoxantrone; Sister Chromatid Exchange; Topoisomerase I Inhibitors

1994
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Mice; Mitoxantrone; Topoisomerase I Inhibitors; Topotecan

1996
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
    British journal of cancer, 1997, Volume: 75, Issue:8

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Survival; DNA, Neoplasm; Female; Humans; Hydrogen-Ion Concentration; Mammary Neoplasms, Experimental; Mice; Mitoxantrone; Paclitaxel; Topotecan; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1997
Evidence against a direct role for the induction of c-jun expression in the mediation of drug-induced apoptosis in human acute leukemia cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cisplatin; Cytarabine; Etoposide; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genes, jun; HL-60 Cells; Humans; Leukemia, B-Cell; Mitoxantrone; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Transfection; Tumor Cells, Cultured

1995
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.
    Cancer research, 1999, Sep-15, Volume: 59, Issue:18

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Drug Resistance, Multiple; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Kinetics; Mitoxantrone; Neoplasm Proteins; Ovarian Neoplasms; Topotecan; Tumor Cells, Cultured

1999
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
    Cancer research, 1999, Dec-01, Volume: 59, Issue:23

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Cell Survival; DNA Damage; Drug Resistance, Multiple; Epirubicin; Female; Glucuronides; Glucuronosyltransferase; Humans; Irinotecan; Microscopy, Confocal; Mitoxantrone; Polymerase Chain Reaction; Topotecan; Tumor Cells, Cultured

1999
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
    Leukemia, 2000, Volume: 14, Issue:4

    Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin

2000
Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.
    Annals of the New York Academy of Sciences, 2000, Volume: 922

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Camptothecin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mitoxantrone; Neoplasm Proteins; Ovarian Neoplasms; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

2000
The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors.
    Mechanisms of ageing and development, 2001, Volume: 122, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Camptothecin; Cycloheximide; DNA Helicases; Drug Resistance, Microbial; Ethylmaleimide; Hydroxyurea; Methyl Methanesulfonate; Mitoxantrone; Mutagenesis; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Topoisomerase I Inhibitors

2001
A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.
    Cancer research, 2001, Aug-15, Volume: 61, Issue:16

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; DNA Damage; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression; HT29 Cells; Humans; Mice; Mice, Nude; Mitoxantrone; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Topotecan; Xenograft Model Antitumor Assays

2001
Combination therapy with irinotecan (CPT-11), mitoxantrone, and dexamethasone in relapsed or refractory non-Hodgkin's lymphoma: a pilot study.
    Annals of hematology, 2001, Volume: 80, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dexamethasone; Female; Humans; Irinotecan; Lymphoma, Non-Hodgkin; Male; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Pilot Projects

2001
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
    Cancer research, 2001, Sep-15, Volume: 61, Issue:18

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Genes, MDR; Genetic Vectors; HeLa Cells; Humans; Irinotecan; Mitoxantrone; Mutation; Neoplasm Proteins; Rhodamine 123; RNA, Messenger; Substrate Specificity; Topotecan; Transfection; Tumor Cells, Cultured; Vaccinia virus

2001
Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:3

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Estrone; Female; Flow Cytometry; Humans; Irinotecan; K562 Cells; Mitoxantrone; Neoplasm Proteins; Topoisomerase I Inhibitors; Topotecan; Transfection

2002
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:8

    Topics: Alternative Splicing; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Base Sequence; Blotting, Northern; Blotting, Western; Camptothecin; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fibroblasts; Heterozygote; Homozygote; Irinotecan; Mice; Mitoxantrone; Molecular Sequence Data; Mutation; Neoplasm Proteins; Polymorphism, Genetic; RNA, Messenger; Sequence Analysis, DNA; Topotecan; Transfection; Tumor Cells, Cultured

2002
The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells.
    International journal of oncology, 2003, Volume: 22, Issue:5

    Topics: Animals; Antineoplastic Agents; BRCA1 Protein; Busulfan; Camptothecin; Cell Division; Cell Line; Doxorubicin; Etoposide; Fibroblasts; Gene Deletion; Genes, BRCA1; Mice; Mitoxantrone; Topotecan; Tumor Suppressor Protein p53

2003
Expression and functional analyses of breast cancer resistance protein in lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Mitoxantrone; Neoplasm Proteins; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Topotecan

2003
Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.
    International journal of cancer, 2003, Dec-10, Volume: 107, Issue:5

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Camptothecin; Cell Line; Cell Membrane; DNA, Complementary; Drug Resistance, Multiple; Fibroblasts; Humans; Irinotecan; Kinetics; Mice; Mitoxantrone; Neoplasm Proteins; Recombinant Proteins; Transfection

2003
Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic.
    International journal of cancer, 2004, Jan-01, Volume: 108, Issue:1

    Topics: Aminocoumarins; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Coumarins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Irinotecan; Lung Neoplasms; Mitoxantrone; Neoplasm Proteins; Novobiocin; Topoisomerase I Inhibitors; Topotecan; Tumor Cells, Cultured

2004
Secretory transport of irinotecan metabolite SN-38 across isolated intestinal tissue.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Transport, Active; Camptothecin; Coloring Agents; Intestine, Small; Irinotecan; Male; Mitoxantrone; Rats; Rats, Wistar; Sulfobromophthalein

2005
Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Breast Neoplasms; Camptothecin; Carcinoma, Small Cell; Cell Line, Tumor; Cell Membrane; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Mitoxantrone; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Topotecan

2005
Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-01, Volume: 11, Issue:11

    Topics: Acute Disease; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 7; Caspases; Cell Cycle; Chlorambucil; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Activation; Flow Cytometry; Gemcitabine; Humans; Irinotecan; Leukemia, Myeloid; Mitoxantrone; Paclitaxel; U937 Cells; Vidarabine

2005
Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.
    Molecular pharmacology, 2006, Volume: 70, Issue:1

    Topics: Adenosine Triphosphate; Alleles; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Camptothecin; Cell Line; Cell Survival; Chlorophyll; Daunorubicin; Doxorubicin; Drug Resistance; Hematoporphyrins; Humans; Irinotecan; Kinetics; Methotrexate; Mitoxantrone; Mutant Proteins; Mutation; Neoplasm Proteins; Polymorphism, Single Nucleotide; Porphyrins; Spodoptera; Transfection

2006
[Development of acute type, CD 8 positive adult T-cell leukemia in a carrier of hepatitis B virus--possible therapeutic effect of lamivudine combined with chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:5

    Topics: Anti-HIV Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carrier State; CD8-Positive T-Lymphocytes; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Hepatitis B; HTLV-I Antibodies; Humans; Irinotecan; Lamivudine; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Mitoxantrone; Nitrosourea Compounds; Pentostatin; Prednisone; Vincristine

2006
Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Oct-01, Volume: 29, Issue:2

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Irinotecan; Mitoxantrone; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Small Interfering

2006
[Effect of several anti-tumor drugs on apoptosis induction in Jurkat cell line].
    Zhongguo shi yan xue ye xue za zhi, 2006, Volume: 14, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor; Harringtonines; Homoharringtonine; Humans; Jurkat Cells; Mitoxantrone

2006
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
    Biochemical pharmacology, 2007, Jun-30, Volume: 74, Issue:1

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Expression Regulation, Neoplastic; Heterozygote; Humans; Indoles; Irinotecan; Mitoxantrone; Neoplasm Proteins; RNA, Messenger; Triazoles

2007
Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Camptothecin; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Etoposide; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Interferon-gamma; Irinotecan; Mitoxantrone

2007
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.
    Cancer letters, 2008, Feb-18, Volume: 260, Issue:1-2

    Topics: Antineoplastic Agents; Camptothecin; Chenodeoxycholic Acid; Dactinomycin; Docetaxel; Fluorescent Dyes; Humans; Irinotecan; Kinetics; Lysine; Mitoxantrone; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Signal Processing, Computer-Assisted; Solute Carrier Organic Anion Transporter Family Member 1B3; Spectrometry, Fluorescence; Taxoids; Transfection

2008
Doxorubicin and mitoxantrone drug eluting beads for the treatment of experimental peritoneal carcinomatosis in colorectal cancer.
    International journal of cancer, 2009, Jun-01, Volume: 124, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Chemoembolization, Therapeutic; Colorectal Neoplasms; Doxorubicin; Female; Irinotecan; Mice; Mice, Inbred BALB C; Mitoxantrone; Peritoneal Neoplasms

2009
Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters.
    Oncogene, 2009, Jun-18, Volume: 28, Issue:24

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Humans; Inhibitory Concentration 50; Irinotecan; Mitoxantrone; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Receptor, TIE-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Up-Regulation

2009
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Camptothecin; Cell Line; Cell Line, Tumor; Dogs; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gefitinib; Humans; Irinotecan; Mitoxantrone; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Time Factors

2010
The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Harmine; Humans; Mitoxantrone; Multidrug Resistance-Associated Proteins; Neoplasm Proteins

2010
BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization.
    Cancer science, 2010, Volume: 101, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Drug Resistance, Neoplasm; Indoles; Irinotecan; Mice; Mitoxantrone; Polymorphism, Single Nucleotide; Protein Multimerization; Transfection

2010
Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.
    Assay and drug development technologies, 2010, Volume: 8, Issue:4

    Topics: Antineoplastic Agents; Biosensing Techniques; Camptothecin; Cell Line, Tumor; Checkpoint Kinase 2; Ellipticines; Genes, p53; High-Throughput Screening Assays; Humans; Imidazoles; Mitoxantrone; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-mdm2; Recombinant Fusion Proteins; Small Molecule Libraries; Spectrometry, Fluorescence; Topotecan; Tumor Suppressor Protein p53

2010
Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.
    Plant signaling & behavior, 2011, Volume: 6, Issue:3

    Topics: Adenosine Triphosphatases; Camptothecin; Cisplatin; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Enzyme Inhibitors; Etoposide; Intercalating Agents; Mitoxantrone; Nogalamycin; Novobiocin; Pisum sativum; Plant Proteins

2011
Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012, Volume: 81, Issue:1

    Topics: Camptothecin; Cell Line, Tumor; DNA Damage; DNA Replication; Etoposide; Histones; Humans; Mitoxantrone; Phosphorylation; Signal Transduction; Topoisomerase Inhibitors; Topotecan

2012
Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents.
    Drug metabolism and drug interactions, 2011, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Camptothecin; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Irinotecan; Mitoxantrone; Organic Cation Transport Proteins; Transfection

2011
Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2012, Volume: 120, Issue:2

    Topics: Animals; Body Weight; Camptothecin; Endothelial Cells; Irinotecan; Male; Mesentery; Mitoxantrone; Neovascularization, Pathologic; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Topoisomerase Inhibitors; Vascular Endothelial Growth Factor A

2012
Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics.
    Methods (San Diego, Calif.), 2012, Volume: 57, Issue:3

    Topics: Antineoplastic Agents; Biological Transport; Camptothecin; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Fluorescence; Humans; Irinotecan; Kinetics; Mitoxantrone; Reactive Oxygen Species; Single-Cell Analysis

2012
A template model for studying anticancer drug efflux transporter inhibitors in vitro.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:5

    Topics: Acridones; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Camptothecin; Cell Membrane; Diffusion; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance; HEK293 Cells; Humans; Intracellular Fluid; Irinotecan; Kinetics; Membrane Transport Modulators; Mitoxantrone; Models, Biological; Neoplasm Proteins; Osmolar Concentration; Recombinant Proteins; Reproducibility of Results

2013
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
    International journal of clinical oncology, 2015, Volume: 20, Issue:2

    Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, Lewis Lung; CD3 Complex; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Histocompatibility Antigens Class I; Humans; Immunomodulation; Lymphocyte Count; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitomycin; Mitoxantrone; Neoplasm Transplantation; Neoplasms, Experimental; Protein Transport; T-Lymphocytes; Tumor Microenvironment

2015
Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.
    Oncotarget, 2016, Aug-02, Volume: 7, Issue:31

    Topics: A549 Cells; Camptothecin; DNA Breaks, Double-Stranded; DNA Damage; Etoposide; Histones; Humans; Microscopy, Confocal; Mitoxantrone; Phosphorylation; Serine; Tumor Suppressor p53-Binding Protein 1

2016
2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations.
    Journal of cellular biochemistry, 2017, Volume: 118, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzamides; Blotting, Western; Camptothecin; Cell Survival; Drug Resistance, Multiple; HEK293 Cells; Humans; Irinotecan; Mitoxantrone

2017
Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:11

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Azides; Benzene Derivatives; Biological Availability; Biological Transport; Camptothecin; Cell Line, Tumor; Curcumin; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Irinotecan; Ketones; Mitoxantrone; Neoplasm Proteins; Prazosin

2017
Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs.
    Chemical communications (Cambridge, England), 2018, Aug-21, Volume: 54, Issue:68

    Topics: Antineoplastic Agents; Berberine; Bridged-Ring Compounds; Camptothecin; Doxorubicin; Drug Carriers; Drug Liberation; Fluorescent Dyes; HeLa Cells; Humans; Hydrogen-Ion Concentration; Imidazoles; Irinotecan; Mitoxantrone; Polymers; Topotecan

2018